Robert K. Doot, Ph.D. - Publications

Affiliations: 
2008 University of Washington, Seattle, Seattle, WA 
Area:
Biomedical Engineering, Radiology

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Nabavizadeh A, Bagley SJ, Doot RK, Ware JB, Young AJ, Ghodasara S, Zhao C, Anderson H, Schubert E, Carpenter EL, Till J, Henderson F, Pantel AR, Chen HI, Lee JYK, et al. Distinguishing Progression from Pseudoprogression in Glioblastoma Using F-Fluciclovine PET. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 36549916 DOI: 10.2967/jnumed.122.264812  0.432
2022 Pantel AR, Gitto SB, Makvandi M, Kim H, Medvedv S, Weeks JK, Torigian DA, Hsieh CJ, Ferman B, Latif NA, Tanyi JL, Martin LP, Lanzo SM, Liu F, Cao Q, ... ... Doot RK, et al. [18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a pilot study. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36441795 DOI: 10.1158/1078-0432.CCR-22-1602  0.394
2022 Doot RK, Young AJ, Nasrallah IM, Wetherill RR, Siderowf A, Mach RH, Dubroff JG. [F]NOS PET Brain Imaging Suggests Elevated Neuroinflammation in Idiopathic Parkinson's Disease. Cells. 11. PMID 36231041 DOI: 10.3390/cells11193081  0.306
2022 Pantel AR, Viswanath V, Muzi M, Doot RK, Mankoff DA. Principles of Tracer Kinetic Analysis in Oncology, Part II: Examples and Future Directions. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 63: 514-521. PMID 35361713 DOI: 10.2967/jnumed.121.263519  0.305
2022 Pantel AR, Viswanath V, Muzi M, Doot RK, Mankoff DA. Principles of Tracer Kinetic Analysis in Oncology, Part I: Principles and Overview of Methodology. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 63: 342-352. PMID 35232879 DOI: 10.2967/jnumed.121.263518  0.396
2022 Lee HS, Schwarz SW, Schubert EK, Chen DL, Doot RK, Makvandi M, Lin LL, McDonald ES, Mankoff DA, Mach RH. The Development of F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1. Radiology. Imaging Cancer. 4: e210070. PMID 35089089 DOI: 10.1148/rycan.210070  0.416
2021 Romine PE, Peterson LM, Kurland BF, Byrd DW, Novakova-Jiresova A, Muzi M, Specht JM, Doot RK, Link JM, Krohn KA, Kinahan PE, Mankoff DA, Linden HM. F-fluorodeoxyglucose (FDG) PET or F-fluorothymidine (FLT) PET to assess early response to aromatase inhibitors (AI) in women with ER+ operable breast cancer in a window-of-opportunity study. Breast Cancer Research : Bcr. 23: 88. PMID 34425871 DOI: 10.1186/s13058-021-01464-1  0.637
2021 McDonald ES, Pantel AR, Shah PD, Farwell MD, Clark AS, Doot RK, Pryma DA, Carlin SD. In vivo visualization of PARP inhibitor pharmacodynamics. Jci Insight. 6. PMID 33884961 DOI: 10.1172/jci.insight.146592  0.409
2021 Young AJ, Pantel AR, Viswanath V, Dominguez TL, Makvandi M, Lee H, Li S, Schubert EK, Pryma DA, Farwell MD, Mach RH, Simpkins F, Lin LL, Mankoff DA, Doot RK. Kinetic and static analysis of poly-(adenosine diphosphate-ribose) polymerase-1 (PARP-1) targeted F-FluorThanatrace (F-FTT) PET images of ovarian cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 33863820 DOI: 10.2967/jnumed.121.261894  0.436
2020 Viswanath V, Zhou R, Lee H, Li S, Cragin A, Doot RK, Mankoff DA, Pantel AR. Kinetic Modeling of F-(2S,4R)4-Fluoroglutamine in Mouse Models of Breast Cancer to Estimate Glutamine Pool Size as an Indicator of Tumor Glutamine Metabolism. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 33277391 DOI: 10.2967/jnumed.120.250977  0.433
2020 Viswanath V, Pantel AR, Daube-Witherspoon ME, Doot R, Muzi M, Mankoff DA, Karp JS. Quantifying bias and precision of kinetic parameter estimation on the PennPET Explorer, a long axial field-of-view scanner. Ieee Transactions On Radiation and Plasma Medical Sciences. 4: 735-749. PMID 33225120 DOI: 10.1109/trpms.2020.3021315  0.313
2020 Doot RK, Young AJ, Daube-Witherspoon ME, Alexoff D, Labban KJ, Lee H, Wu Z, Zha Z, Choi SR, Ploessl KH, Schubert EK, Lee H, Zhu L, Reddin JS, Karp JS, et al. Biodistribution, dosimetry, and temporal signal-to-noise ratio analyses of normal and cancer uptake of [Ga]Ga-P15-041, a gallium-68 labeled bisphosphonate, from first-in-human studies. Nuclear Medicine and Biology. 86: 1-8. PMID 32361089 DOI: 10.1016/J.Nucmedbio.2020.04.002  0.309
2020 McDonald ES, Doot RK, Pantel AR, Farwell MD, Mach RH, Maxwell KN, Mankoff DA. Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial. Jama Oncology. PMID 32297911 DOI: 10.1001/Jamaoncol.2020.0334  0.436
2020 Henderson F, Brem S, O'Rourke DM, Nasrallah M, Buch VP, Young AJ, Doot RK, Pantel A, Desai A, Bagley SJ, Nabavizadeh SA. F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling. Neuro-Oncology Practice. 7: 152-157. PMID 32206320 DOI: 10.1093/Nop/Npz068  0.462
2019 McDonald ES, Doot RK, Young AJ, Schubert EK, Pryma DA, Farwell MD, Tchou J, Nayak A, Ziober A, Feldman MD, DeMichele A, Clark AS, Shah PD, Lee H, Carlin SD, et al. Breast Cancer F-ISO-1 Uptake as a Marker of Proliferation Status. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 31836680 DOI: 10.2967/Jnumed.119.232363  0.526
2019 Doot RK. Practical methods for estimating metabolic flux (Ki) to assess response to therapy via static PET scans. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 30683760 DOI: 10.2967/Jnumed.118.220913  0.45
2019 McDonald E, Carlin S, Maxwell K, Nayak A, Doot R, Pantel A, Farwell, Pryma D, Clark A, Shah P, DeMichele A, Ziober A, Schubert E, Palmer K, Lee H, et al. Abstract PD4-07: PET imaging of PARP-1 expression in breast cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Sabcs18-Pd4-07  0.441
2018 Doot RK, Dubroff JG, Labban KJ, Mach RH. Selectivity of probes for PET imaging of dopamine D3 receptors. Neuroscience Letters. PMID 29518538 DOI: 10.1016/J.Neulet.2018.03.006  0.33
2018 Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, et al. A PET imaging agent for evaluating PARP-1 expression in ovarian cancer. The Journal of Clinical Investigation. PMID 29509546 DOI: 10.1172/Jci97992  0.445
2018 Davatzikos C, Rathore S, Bakas S, Pati S, Bergman M, Kalarot R, Sridharan P, Gastounioti A, Jahani N, Cohen E, Akbari H, Tunc B, Doshi J, Parker D, Hsieh M, ... ... Doot RK, et al. Cancer imaging phenomics toolkit: quantitative imaging analytics for precision diagnostics and predictive modeling of clinical outcome. Journal of Medical Imaging (Bellingham, Wash.). 5: 011018. PMID 29340286 DOI: 10.1117/1.Jmi.5.1.011018  0.367
2018 O'Sullivan F, O'Sullivan JN, Huang J, Doot R, Muzi M, Schubert E, Peterson L, Dunnwald LK, Mankoff DM. Assessment of a statistical AIF extraction method for dynamic PET studies with 15O water and 18F fluorodeoxyglucose in locally advanced breast cancer patients. Journal of Medical Imaging (Bellingham, Wash.). 5: 011010. PMID 29201941 DOI: 10.1117/1.Jmi.5.1.011010  0.523
2018 Makvandi M, Pantel A, Schwartz L, Doot R, Simpkins F, Mankoff DA, Mach RH, Lin L. Abstract A054: Real-time imaging of PARP-1 in ovarian cancer Molecular Cancer Therapeutics. 17. DOI: 10.1158/1535-7163.Targ-17-A054  0.539
2017 Hou C, Hsieh CJ, Li S, Lee H, Graham TJA, Xu K, Weng CC, Doot RK, Chu W, Chakraborty SK, Dugan LL, Mintun MA, Mach R. Development of a PET Radiotracer for Imaging Elevated Levels of Superoxide in Neuroinflammation. Acs Chemical Neuroscience. PMID 29099578 DOI: 10.1021/Acschemneuro.7B00385  0.5
2017 Lin L, Makvandi M, Pantel A, Doot R, Schwartz L, Simpkins F, Mankoff D, Mach R. Abstract AP20: A PILOT STUDY OF A POLY (ADP–RIBOSE) POLYMERASE–1 (PARP) TARGETED NOVEL PET TRACER (18F–FLUOURTHANOTRACE) IN PATIENTS WITH OVARIAN CARCINOMA Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Ovcasymp16-Ap20  0.584
2017 Makvandi M, Pantel A, Schwartz LE, Xu K, Hsieh C, Kim H, Li S, Doot R, Lee S, Simpkins F, Greenberg RA, Mankoff DA, Mach RH, Lin L. Abstract 3716: Exploring the significance of PARP-1 expression for therapy and clinical PET/CT imaging of PARP-1 in ovarian cancer Cancer Research. 77: 3716-3716. DOI: 10.1158/1538-7445.Am2017-3716  0.513
2017 Pantel AR, Lee H, Li S, Doot RK, Mach RH, Mankoff DA, Zhou R. Abstract 2851: Cellular glutamine pool size change in response to glutaminase inhibition detected by kinetic analysis of [18F](2S,4R)4-fluoroglutamine PET Cancer Research. 77: 2851-2851. DOI: 10.1158/1538-7445.Am2017-2851  0.445
2016 Byrd DW, Doot RK, Allberg KC, MacDonald LR, McDougald WA, Elston BF, Linden HM, Kinahan PE. Evaluation of Cross-Calibrated (68)Ge/(68)Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials. Tomography : a Journal For Imaging Research. 2: 353-360. PMID 28066807 DOI: 10.18383/j.tom.2016.00205  0.652
2016 Doot RK. Invited Perspective for: 18F-FDG PET derived tumor blood flow changes after one cycle of neoadjuvant chemotherapy predicts outcome in triple-negative breast cancer. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 27261517 DOI: 10.2967/Jnumed.116.175687  0.485
2016 Kurland BF, Muzi M, Peterson LM, Doot RK, Wangerin KA, Mankoff DA, Linden HM, Kinahan PE. Multicenter Clinical Trials Using 18F-FDG PET to Measure Early Response to Oncologic Therapy: Effects of Injection-to-Acquisition Time Variability on Required Sample Size. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 57: 226-30. PMID 26493206 DOI: 10.2967/Jnumed.115.162289  0.674
2016 Roberts TK, Peterson L, Kurland B, Novakova A, Shields A, Doot RK, Schubert EK, Gadi VK, Specht JM, Gralow J, Eary JF, Muzi M, Link J, Krohn KA, Mankoff DA, et al. Use of serial 18F-Fluorothymidine (FLT) PET and Ki-67 to predict response to aromatase inhibitors (AI) in women with ER+ breast cancer. Journal of Clinical Oncology. 34: e12039-e12039. DOI: 10.1200/Jco.2016.34.15_Suppl.E12039  0.529
2016 Specht JM, Peterson L, Novakova A, O'Sullivan JN, O'Sullivan F, Shields A, Montgomery S, Linden HM, Gralow J, Ellis GK, Gadi VK, Barlow WE, Doot RK, Schubert EK, Dunnwald LK, et al. Serial FDG-PET to predict response, time to skeletal related events, and survival in patients with bone-dominant metastatic breast cancer. Journal of Clinical Oncology. 34: 11569-11569. DOI: 10.1200/Jco.2016.34.15_Suppl.11569  0.618
2015 Dubroff JG, Doot RK, Falcone M, Schnoll RA, Ray R, Tyndale RF, Brody AL, Hou C, Schmitz A, Lerman C. Decreased Nicotinic Receptor Availability in Smokers with Slow Rates of Nicotine Metabolism. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 56: 1724-9. PMID 26272810 DOI: 10.2967/Jnumed.115.155002  0.322
2015 Yu EY, Duan F, Muzi M, Deng X, Chin BB, Alumkal JJ, Taplin ME, Taub JM, Herman B, Higano CS, Doot RK, Hartfeil D, Febbo PG, Mankoff DA. Castration-resistant prostate cancer bone metastasis response measured by 18F-fluoride PET after treatment with dasatinib and correlation with progression-free survival: results from American College of Radiology Imaging Network 6687. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 56: 354-60. PMID 25635138 DOI: 10.2967/Jnumed.114.146936  0.473
2014 Doot RK, McDonald ES, Mankoff DA. Role of PET quantitation in the monitoring of cancer response to treatment: Review of approaches and human clinical trials. Clinical and Translational Imaging. 2: 295-303. PMID 25229053 DOI: 10.1007/S40336-014-0071-1  0.574
2014 Harrison RL, Elston BF, Doot RK, Lewellen TK, Mankoff DA, Kinahan PE. A Virtual Clinical Trial of FDG-PET Imaging of Breast Cancer: Effect of Variability on Response Assessment. Translational Oncology. 7: 138-46. PMID 24772217 DOI: 10.1593/Tlo.13847  0.682
2014 Doot RK, Pierce LA, Byrd D, Elston B, Allberg KC, Kinahan PE. Biases in Multicenter Longitudinal PET Standardized Uptake Value Measurements. Translational Oncology. 7: 48-54. PMID 24772207 DOI: 10.1593/Tlo.13850  0.674
2013 Kurland BF, Doot RK, Linden HM, Mankoff DA, Kinahan PE. Multicenter trials using ¹⁸F-fluorodeoxyglucose (FDG) PET to predict chemotherapy response: effects of differential measurement error and bias on power calculations for unselected and enrichment designs. Clinical Trials (London, England). 10: 886-95. PMID 24169628 DOI: 10.1177/1740774513506618  0.603
2013 Yu EY, Duan F, Muzi M, Gorelick J, Chin B, Alumkal JJ, Taplin M, Herman B, Higano CS, Doot RK, Hartfeil DM, Febbo PG, Mankoff DA. Correlation of 18F-fluoride PET response to dasatinib in castration-resistant prostate cancer bone metastases with progression-free survival: Preliminary results from ACRIN 6687. Journal of Clinical Oncology. 31: 5003-5003. DOI: 10.1200/Jco.2013.31.15_Suppl.5003  0.462
2012 Muzi M, O'Sullivan F, Mankoff DA, Doot RK, Pierce LA, Kurland BF, Linden HM, Kinahan PE. Quantitative assessment of dynamic PET imaging data in cancer imaging. Magnetic Resonance Imaging. 30: 1203-15. PMID 22819579 DOI: 10.1016/J.Mri.2012.05.008  0.629
2012 Doot RK, Thompson T, Greer BE, Allberg KC, Linden HM, Mankoff DA, Kinahan PE. Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials. Magnetic Resonance Imaging. 30: 1291-300. PMID 22795929 DOI: 10.1016/J.Mri.2012.06.002  0.636
2012 Doot RK, Kurland BF, Kinahan PE, Mankoff DA. Design considerations for using PET as a response measure in single site and multicenter clinical trials. Academic Radiology. 19: 184-90. PMID 22104290 DOI: 10.1016/J.Acra.2011.10.008  0.695
2012 Currin ER, Dunnwald LK, Doot RK, Schubert EK, Kurland BF, Mankoff DA, Specht JM. Quantitative measures of FDG PET after neoadjuvant chemotherapy to predict breast cancer patient survival. Journal of Clinical Oncology. 30: 1088-1088. DOI: 10.1200/Jco.2012.30.15_Suppl.1088  0.501
2011 Dunnwald LK, Doot RK, Specht JM, Gralow JR, Ellis GK, Livingston RB, Linden HM, Gadi VK, Kurland BF, Schubert EK, Muzi M, Mankoff DA. PET tumor metabolism in locally advanced breast cancer patients undergoing neoadjuvant chemotherapy: value of static versus kinetic measures of fluorodeoxyglucose uptake. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 2400-9. PMID 21364034 DOI: 10.1158/1078-0432.Ccr-10-2649  0.533
2011 Lockhart CM, MacDonald LR, Alessio AM, McDougald WA, Doot RK, Kinahan PE. Quantifying and reducing the effect of calibration error on variability of PET/CT standardized uptake value measurements. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 52: 218-24. PMID 21233174 DOI: 10.2967/Jnumed.110.083865  0.589
2010 Doot RK, Scheuermann JS, Christian PE, Karp JS, Kinahan PE. Instrumentation factors affecting variance and bias of quantifying tracer uptake with PET/CT. Medical Physics. 37: 6035-46. PMID 21158315 DOI: 10.1118/1.3499298  0.681
2010 Partridge SC, Vanantwerp RK, Doot RK, Chai X, Kurland BF, Eby PR, Specht JM, Dunnwald LK, Schubert EK, Lehman CD, Mankoff DA. Association between serial dynamic contrast-enhanced MRI and dynamic 18F-FDG PET measures in patients undergoing neoadjuvant chemotherapy for locally advanced breast cancer. Journal of Magnetic Resonance Imaging : Jmri. 32: 1124-31. PMID 21031518 DOI: 10.1002/Jmri.22362  0.571
2010 Fahey FH, Kinahan PE, Doot RK, Kocak M, Thurston H, Poussaint TY. Variability in PET quantitation within a multicenter consortium. Medical Physics. 37: 3660-6. PMID 20831073 DOI: 10.1118/1.3455705  0.617
2010 Specht JM, Kurland BF, Montgomery SK, Dunnwald LK, Doot RK, Gralow JR, Ellis GK, Linden HM, Livingston RB, Allison KH, Schubert EK, Mankoff DA. Tumor metabolism and blood flow as assessed by positron emission tomography varies by tumor subtype in locally advanced breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2803-10. PMID 20460489 DOI: 10.1158/1078-0432.Ccr-10-0026  0.407
2010 Doot RK, Muzi M, Peterson LM, Schubert EK, Gralow JR, Specht JM, Mankoff DA. Kinetic analysis of 18F-fluoride PET images of breast cancer bone metastases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 51: 521-7. PMID 20237040 DOI: 10.2967/Jnumed.109.070052  0.434
2009 Kinahan PE, Doot RK, Wanner-Roybal M, Bidaut LM, Armato SG, Meyer CR, McLennan G. PET/CT Assessment of Response to Therapy: Tumor Change Measurement, Truth Data, and Error. Translational Oncology. 2: 223-30. PMID 19956382 DOI: 10.1593/Tlo.09223  0.694
2008 Eby PR, Partridge SC, White SW, Doot RK, Dunnwald LK, Schubert EK, Kurland BF, Lehman CD, Mankoff DA. Metabolic and vascular features of dynamic contrast-enhanced breast magnetic resonance imaging and (15)O-water positron emission tomography blood flow in breast cancer. Academic Radiology. 15: 1246-54. PMID 18790395 DOI: 10.1016/J.Acra.2008.03.019  0.531
2008 Dunnwald LK, Gralow JR, Ellis GK, Livingston RB, Linden HM, Specht JM, Doot RK, Lawton TJ, Barlow WE, Kurland BF, Schubert EK, Mankoff DA. Tumor metabolism and blood flow changes by positron emission tomography: relation to survival in patients treated with neoadjuvant chemotherapy for locally advanced breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 4449-57. PMID 18626006 DOI: 10.1200/Jco.2007.15.4385  0.516
2007 Doot RK, Dunnwald LK, Schubert EK, Muzi M, Peterson LM, Kinahan PE, Kurland BF, Mankoff DA. Dynamic and static approaches to quantifying 18F-FDG uptake for measuring cancer response to therapy, including the effect of granulocyte CSF. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 48: 920-5. PMID 17504870 DOI: 10.2967/Jnumed.106.037382  0.657
2007 Partridge SC, Eby PR, Doot RK, White SW, Kurland BF, Schubert EK, Dunnwald LK, Lehman CD, Mankoff DA. Comparison of vascularity measures from PET and MRI for improved breast tumor characterization and therapeutic response evaluation Journal of Clinical Oncology. 25: 589-589. DOI: 10.1200/Jco.2007.25.18_Suppl.589  0.46
2007 Dunnwald L, Gralow J, Ellis G, Livingston R, Linden H, Specht J, Doot R, Lawton T, Barlow W, Mankoff D. Tumor metabolism, blood flow changes, and prognosis by positron emission tomography: A prospective cohort of locally advanced breast cancer patients Journal of Clinical Oncology. 25: 506-506. DOI: 10.1200/Jco.2007.25.18_Suppl.506  0.426
2007 Doot RK, Christian PE, Mankoff DA, Kinahan PE. Reproducibility of quantifying tracer uptake with PET/CT for evaluation of response to therapy Ieee Nuclear Science Symposium Conference Record. 4: 2833-2837. DOI: 10.1109/NSSMIC.2007.4436726  0.624
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