Michael Wigler - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Area:
Cancer, Molecular Biology

194 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wang Z, Andrews P, Kendall J, Ma B, Hakker I, Rodgers L, Ronemus M, Wigler M, Levy D. SMASH, a fragmentation and sequencing method for genomic copy number analysis. Genome Research. PMID 27197213 DOI: 10.1101/gr.201491.115  1
2015 Iossifov I, Levy D, Allen J, Ye K, Ronemus M, Lee YH, Yamrom B, Wigler M. Low load for disruptive mutations in autism genes and their biased transmission. Proceedings of the National Academy of Sciences of the United States of America. PMID 26401017 DOI: 10.1073/pnas.1516376112  1
2015 Garvin T, Aboukhalil R, Kendall J, Baslan T, Atwal GS, Hicks J, Wigler M, Schatz MC. Interactive analysis and assessment of single-cell copy-number variations. Nature Methods. 12: 1058-60. PMID 26344043 DOI: 10.1038/nmeth.3578  1
2015 Baslan T, Kendall J, Ward B, Cox H, Leotta A, Rodgers L, Riggs M, D'Italia S, Sun G, Yong M, Miskimen K, Gilmore H, Saborowski M, Dimitrova N, Krasnitz A, ... ... Wigler M, et al. Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research. 25: 714-24. PMID 25858951 DOI: 10.1101/gr.188060.114  1
2015 Jayaprakash AD, Benson EK, Gone S, Liang R, Shim J, Lambertini L, Toloue MM, Wigler M, Aaronson SA, Sachidanandam R. Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Research. 43: 2177-87. PMID 25653158 DOI: 10.1093/nar/gkv052  1
2015 Rye IH, Lundin P, Månér S, Fjelldal R, Naume B, Wigler M, Hicks J, Børresen-Dale AL, Zetterberg A, Russnes HG. Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors. Genes, Chromosomes & Cancer. 54: 235-48. PMID 25546585 DOI: 10.1002/gcc.22237  1
2014 Iossifov I, O'Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, Stessman HA, Witherspoon KT, Vives L, Patterson KE, Smith JD, Paeper B, Nickerson DA, Dea J, Dong S, ... ... Wigler M, et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature. 515: 216-21. PMID 25363768 DOI: 10.1038/nature13908  1
2014 Levy D, Wigler M. Facilitated sequence counting and assembly by template mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 111: E4632-7. PMID 25313059 DOI: 10.1073/pnas.1416204111  1
2014 Narzisi G, O'Rawe JA, Iossifov I, Fang H, Lee YH, Wang Z, Wu Y, Lyon GJ, Wigler M, Schatz MC. Accurate de novo and transmitted indel detection in exome-capture data using microassembly. Nature Methods. 11: 1033-6. PMID 25128977 DOI: 10.1038/nmeth.3069  1
2014 Dago AE, Stepansky A, Carlsson A, Luttgen M, Kendall J, Baslan T, Kolatkar A, Wigler M, Bethel K, Gross ME, Hicks J, Kuhn P. Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. Plos One. 9: e101777. PMID 25084170 DOI: 10.1371/journal.pone.0101777  1
2014 Ronemus M, Iossifov I, Levy D, Wigler M. The role of de novo mutations in the genetics of autism spectrum disorders. Nature Reviews. Genetics. 15: 133-41. PMID 24430941 DOI: 10.1038/nrg3585  1
2014 Warburton D, Ronemus M, Kline J, Jobanputra V, Williams I, Anyane-Yeboa K, Chung W, Yu L, Wong N, Awad D, Yu CY, Leotta A, Kendall J, Yamrom B, Lee YH, ... Wigler M, et al. The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease. Human Genetics. 133: 11-27. PMID 23979609 DOI: 10.1007/s00439-013-1353-9  1
2013 Shi J, Whyte WA, Zepeda-Mendoza CJ, Milazzo JP, Shen C, Roe JS, Minder JL, Mercan F, Wang E, Eckersley-Maslin MA, Campbell AE, Kawaoka S, Shareef S, Zhu Z, Kendall J, ... ... Wigler MH, et al. Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes & Development. 27: 2648-62. PMID 24285714 DOI: 10.1101/gad.232710.113  1
2013 Krasnitz A, Sun G, Andrews P, Wigler M. Target inference from collections of genomic intervals. Proceedings of the National Academy of Sciences of the United States of America. 110: E2271-8. PMID 23744040 DOI: 10.1073/pnas.1306909110  1
2013 Donnenberg AD, Hicks JB, Wigler M, Donnenberg VS. The cancer stem cell: cell type or cell state? Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 83: 5-7. PMID 23081699 DOI: 10.1002/cyto.a.22208  1
2012 Wigler M. Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Medicine. 4: 79. PMID 23114035 DOI: 10.1186/gm380  1
2012 Stadler ZK, Esposito D, Shah S, Vijai J, Yamrom B, Levy D, Lee YH, Kendall J, Leotta A, Ronemus M, Hansen N, Sarrel K, Rau-Murthy R, Schrader K, Kauff N, ... ... Wigler M, et al. Rare de novo germline copy-number variation in testicular cancer. American Journal of Human Genetics. 91: 379-83. PMID 22863192 DOI: 10.1016/j.ajhg.2012.06.019  1
2012 Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, ... ... Wigler M, et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America. 109: 8212-7. PMID 22566646 DOI: 10.1073/pnas.1206062109  1
2012 Baslan T, Kendall J, Rodgers L, Cox H, Riggs M, Stepansky A, Troge J, Ravi K, Esposito D, Lakshmi B, Wigler M, Navin N, Hicks J. Genome-wide copy number analysis of single cells. Nature Protocols. 7: 1024-41. PMID 22555242 DOI: 10.1038/nprot.2012.039  1
2012 Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee YH, Narzisi G, Leotta A, Kendall J, Grabowska E, Ma B, Marks S, Rodgers L, ... ... Wigler M, et al. De novo gene disruptions in children on the autistic spectrum. Neuron. 74: 285-99. PMID 22542183 DOI: 10.1016/j.neuron.2012.04.009  1
2012 Lee YH, Ronemus M, Kendall J, Lakshmi B, Leotta A, Levy D, Esposito D, Grubor V, Ye K, Wigler M, Yamrom B. Reducing system noise in copy number data using principal components of self-self hybridizations. Proceedings of the National Academy of Sciences of the United States of America. 109: E103-10. PMID 22207624 DOI: 10.1073/pnas.1106233109  1
2012 Wigler M. The last ten yards From Linear Operators to Computational Biology: Essays in Memory of Jacob T. Schwartz. 195-202. DOI: 10.1007/978-1-4471-4282-9_10  1
2011 Horev G, Ellegood J, Lerch JP, Son YE, Muthuswamy L, Vogel H, Krieger AM, Buja A, Henkelman RM, Wigler M, Mills AA. Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism. Proceedings of the National Academy of Sciences of the United States of America. 108: 17076-81. PMID 21969575 DOI: 10.1073/pnas.1114042108  1
2011 Gilman SR, Iossifov I, Levy D, Ronemus M, Wigler M, Vitkup D. Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses. Neuron. 70: 898-907. PMID 21658583 DOI: 10.1016/j.neuron.2011.05.021  1
2011 Levy D, Ronemus M, Yamrom B, Lee YH, Leotta A, Kendall J, Marks S, Lakshmi B, Pai D, Ye K, Buja A, Krieger A, Yoon S, Troge J, Rodgers L, ... ... Wigler M, et al. Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron. 70: 886-97. PMID 21658582 DOI: 10.1016/j.neuron.2011.05.015  1
2011 Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D, Muthuswamy L, Krasnitz A, McCombie WR, Hicks J, Wigler M. Tumour evolution inferred by single-cell sequencing. Nature. 472: 90-4. PMID 21399628 DOI: 10.1038/nature09807  1
2011 Kamalakaran S, Varadan V, Giercksky Russnes HE, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, KÃ¥resen R, Shama Prasada K, Rotti H, Rao R, Rao L, ... ... Wigler M, et al. DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology. 5: 77-92. PMID 21169070 DOI: 10.1016/j.molonc.2010.11.002  1
2010 Russnes HG, Vollan HK, Lingjaerde OC, Krasnitz A, Lundin P, Naume B, Sørlie T, Borgen E, Rye IH, Langerød A, Chin SF, Teschendorff AE, Stephens PJ, MÃ¥nér S, Schlichting E, ... ... Wigler M, et al. Genomic architecture characterizes tumor progression paths and fate in breast cancer patients. Science Translational Medicine. 2: 38ra47. PMID 20592421 DOI: 10.1126/scitranslmed.3000611  1
2010 Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J, Riggs M, Eberling Y, Troge J, Grubor V, Levy D, Lundin P, MÃ¥nér S, Zetterberg A, Hicks J, ... Wigler M, et al. Inferring tumor progression from genomic heterogeneity. Genome Research. 20: 68-80. PMID 19903760 DOI: 10.1101/gr.099622.109  1
2009 Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 16: 324-35. PMID 19800577 DOI: 10.1016/j.ccr.2009.08.015  1
2009 Hodges E, Smith AD, Kendall J, Xuan Z, Ravi K, Rooks M, Zhang MQ, Ye K, Bhattacharjee A, Brizuela L, McCombie WR, Wigler M, Hannon GJ, Hicks JB. High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Research. 19: 1593-605. PMID 19581485 DOI: 10.1101/gr.095190.109  1
2009 Grubor V, Krasnitz A, Troge JE, Meth JL, Lakshmi B, Kendall JT, Yamrom B, Alex G, Pai D, Navin N, Hufnagel LA, Lee YH, Cook K, Allen SL, Rai KR, ... ... Wigler M, et al. Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA). Blood. 113: 1294-303. PMID 18922857 DOI: 10.1182/blood-2008-05-158865  1
2008 Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 135: 852-64. PMID 19012953 DOI: 10.1016/j.cell.2008.09.061  1
2008 Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development. 22: 1439-44. PMID 18519636 DOI: 10.1101/gad.1672608  1
2008 Alarcón M, Abrahams BS, Stone JL, Duvall JA, Perederiy JV, Bomar JM, Sebat J, Wigler M, Martin CL, Ledbetter DH, Nelson SF, Cantor RM, Geschwind DH. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. American Journal of Human Genetics. 82: 150-9. PMID 18179893 DOI: 10.1016/j.ajhg.2007.09.005  1
2008 Gupta L, Kumar S, Singh R, Shaik R, Dimitrova N, Gorthi A, Lakshmi B, Pai D, Kamalakaran S, Zhao X, Wigler M. Classification method for microarray probe selection using sequence, thermodynamics and secondary structure parameters Proceedings - International Conference On Pattern Recognition 1
2007 Egan CM, Sridhar S, Wigler M, Hall IM. Recurrent DNA copy number variation in the laboratory mouse. Nature Genetics. 39: 1384-9. PMID 17965714 DOI: 10.1038/ng.2007.19  1
2007 Lucito R, Suresh S, Walter K, Pandey A, Lakshmi B, Krasnitz A, Sebat J, Wigler M, Klein AP, Brune K, Palmisano E, Maitra A, Goggins M, Hruban RH. Copy-number variants in patients with a strong family history of pancreatic cancer. Cancer Biology & Therapy. 6: 1592-9. PMID 17912030  1
2007 Zhao X, Leotta A, Kustanovich V, Lajonchere C, Geschwind DH, Law K, Law P, Qiu S, Lord C, Sebat J, Ye K, Wigler M. A unified genetic theory for sporadic and inherited autism. Proceedings of the National Academy of Sciences of the United States of America. 104: 12831-6. PMID 17652511 DOI: 10.1073/pnas.0705803104  1
2007 Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, ... ... Wigler M, et al. Strong association of de novo copy number mutations with autism. Science (New York, N.Y.). 316: 445-9. PMID 17363630 DOI: 10.1126/science.1138659  1
2006 Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KC, Navin N, Hicks J, Mu D, Powers S, Wigler M, Botstein D. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 103: 19848-53. PMID 17167050 DOI: 10.1073/pnas.0609635104  1
2006 Hicks J, Krasnitz A, Lakshmi B, Navin NE, Riggs M, Leibu E, Esposito D, Alexander J, Troge J, Grubor V, Yoon S, Wigler M, Ye K, Børresen-Dale AL, Naume B, et al. Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Research. 16: 1465-79. PMID 17142309 DOI: 10.1101/gr.5460106  1
2006 Lakshmi B, Hall IM, Egan C, Alexander J, Leotta A, Healy J, Zender L, Spector MS, Xue W, Lowe SW, Wigler M, Lucito R. Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proceedings of the National Academy of Sciences of the United States of America. 103: 11234-9. PMID 16844783 DOI: 10.1073/pnas.0602984103  1
2006 Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 125: 1253-67. PMID 16814713 DOI: 10.1016/j.cell.2006.05.030  1
2006 Navin N, Grubor V, Hicks J, Leibu E, Thomas E, Troge J, Riggs M, Lundin P, MÃ¥nér S, Sebat J, Zetterberg A, Wigler M. PROBER: oligonucleotide FISH probe design software. Bioinformatics (Oxford, England). 22: 2437-8. PMID 16740623 DOI: 10.1093/bioinformatics/btl273  1
2006 West J, Healy J, Wigler M, Casey W, Mishra B. Validation of S. pombe sequence assembly by microarray hybridization. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. 13: 1-20. PMID 16472019 DOI: 10.1089/cmb.2006.13.1  1
2005 Hicks J, Muthuswamy L, Krasnitz A, Navin N, Riggs M, Grubor V, Esposito D, Alexander J, Troge J, Wigler M, Maner S, Lundin P, Zetterberg A. High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors. Cold Spring Harbor Symposia On Quantitative Biology. 70: 51-63. PMID 16869738 DOI: 10.1101/sqb.2005.70.055  1
2005 Jobanputra V, Sebat J, Troge J, Chung W, Anyane-Yeboa K, Wigler M, Warburton D. Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 7: 111-8. PMID 15714078 DOI: 10.1097/01.GIM.0000153661.11110.FB  1
2004 Daruwala RS, Rudra A, Ostrer H, Lucito R, Wigler M, Mishra B. A versatile statistical analysis algorithm to detect genome copy number variation. Proceedings of the National Academy of Sciences of the United States of America. 101: 16292-7. PMID 15534219 DOI: 10.1073/pnas.0407247101  1
2004 Olshen AB, Venkatraman ES, Lucito R, Wigler M. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics (Oxford, England). 5: 557-72. PMID 15475419 DOI: 10.1093/biostatistics/kxh008  1
2004 Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, MÃ¥nér S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, ... ... Wigler M, et al. Large-scale copy number polymorphism in the human genome. Science (New York, N.Y.). 305: 525-8. PMID 15273396 DOI: 10.1126/science.1098918  1
2004 Thomas EE, Srebro N, Sebat J, Navin N, Healy J, Mishra B, Wigler M. Distribution of short paired duplications in mammalian genomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10349-54. PMID 15240876 DOI: 10.1073/pnas.0403727101  1
2003 Mishra B, Daruwala RS, Zhou Y, Ugel N, Policriti A, Antoniotti M, Paxia S, Rejali M, Rudra A, Cherepinsky V, Silver N, Casey W, Piazza C, Simeoni M, Barbano P, ... ... Wigler M, et al. A sense of life: computational and experimental investigations with models of biochemical and evolutionary processes. Omics : a Journal of Integrative Biology. 7: 253-68. PMID 14583115 DOI: 10.1089/153623103322452387  1
2003 Healy J, Thomas EE, Schwartz JT, Wigler M. Annotating large genomes with exact word matches. Genome Research. 13: 2306-15. PMID 12975312 DOI: 10.1101/gr.1350803  1
2003 Lucito R, Healy J, Alexander J, Reiner A, Esposito D, Chi M, Rodgers L, Brady A, Sebat J, Troge J, West JA, Rostan S, Nguyen KC, Powers S, Ye KQ, ... ... Wigler M, et al. Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Research. 13: 2291-305. PMID 12975311 DOI: 10.1101/gr.1349003  1
2003 Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, ... ... Wigler MH, et al. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell. 3: 297-302. PMID 12676587 DOI: 10.1016/S1535-6108(03)00054-0  1
2002 Hamaguchi M, Meth JL, von Klitzing C, Wei W, Esposito D, Rodgers L, Walsh T, Welcsh P, King MC, Wigler MH. DBC2, a candidate for a tumor suppressor gene involved in breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 99: 13647-52. PMID 12370419 DOI: 10.1073/pnas.212516099  1
2002 Wigler M, Mishra B. Genetics. Wild by nature. Science (New York, N.Y.). 296: 1407-8. PMID 12029116 DOI: 10.1126/science.1072445  1
2001 Scheffzek K, Grünewald P, Wohlgemuth S, Kabsch W, Tu H, Wigler M, Wittinghofer A, Herrmann C. The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure (London, England : 1993). 9: 1043-50. PMID 11709168 DOI: 10.1016/S0969-2126(01)00674-8  1
2001 Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH, Mittal V. Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 98: 13043-8. PMID 11687610 DOI: 10.1073/pnas.221450598  1
2001 Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL. PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 4622-7. PMID 11274365 DOI: 10.1073/pnas.081063798  1
2000 Lucito R, West J, Reiner A, Alexander J, Esposito D, Mishra B, Powers S, Norton L, Wigler M. Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Research. 10: 1726-36. PMID 11076858 DOI: 10.1101/gr.138300  1
1999 Dong DL, Liu R, Sherlock R, Wigler MH, Nestler HP. Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus. Chemistry & Biology. 6: 133-41. PMID 10074468 DOI: 10.1016/S1074-5521(99)89005-X  1
1999 Tu H, Wigler M. Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Molecular and Cellular Biology. 19: 602-11. PMID 9858584  1
1998 Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proceedings of the National Academy of Sciences of the United States of America. 95: 13513-8. PMID 9811831 DOI: 10.1073/pnas.95.23.13513  1
1998 Webb CP, Van Aelst L, Wigler MH, Vande Woude GF. Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 95: 8773-8. PMID 9671754 DOI: 10.1073/pnas.95.15.8773  1
1998 Lucito R, Nakimura M, West JA, Han Y, Chin K, Jensen K, McCombie R, Gray JW, Wigler M. Genetic analysis using genomic representations. Proceedings of the National Academy of Sciences of the United States of America. 95: 4487-92. PMID 9539764 DOI: 10.1073/pnas.95.8.4487  1
1998 Hamaguchi M, O'Connor EA, Chen T, Parnell L, McCombie RW, Wigler MH. Rapid isolation of cDNA by hybridization. Proceedings of the National Academy of Sciences of the United States of America. 95: 3764-9. PMID 9520441 DOI: 10.1073/pnas.95.7.3764  1
1997 Tu H, Barr M, Dong DL, Wigler M. Multiple regulatory domains on the Byr2 protein kinase. Molecular and Cellular Biology. 17: 5876-87. PMID 9315645  1
1997 Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 94: 9052-7. PMID 9256433 DOI: 10.1073/pnas.94.17.9052  1
1997 Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, ... Wigler MH, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (New York, N.Y.). 275: 1943-7. PMID 9072974 DOI: 10.1126/science.275.5308.1943  1
1996 Xu HP, Yanak BL, Wigler MH, Gorin MB. New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 7: 16-9. PMID 8903722  1
1996 Barr MM, Tu H, Van Aelst L, Wigler M. Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Molecular and Cellular Biology. 16: 5597-603. PMID 8816472  1
1996 Thiagalingam S, Lisitsyn NA, Hamaguchi M, Wigler MH, Willson JK, Markowitz SD, Leach FS, Kinzler KW, Vogelstein B. Evaluation of the FHIT gene in colorectal cancers. Cancer Research. 56: 2936-9. PMID 8674044  1
1996 Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Molecular and Cellular Biology. 16: 3923-33. PMID 8668210  1
1996 White MA, Vale T, Camonis JH, Schaefer E, Wigler MH. A role for the Ral guanine nucleotide dissociation stimulator in mediating Ras-induced transformation. The Journal of Biological Chemistry. 271: 16439-42. PMID 8663585 DOI: 10.1074/jbc.271.28.16439  1
1996 Joneson T, White MA, Wigler MH, Bar-Sagi D. Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS. Science (New York, N.Y.). 271: 810-2. PMID 8628998  1
1995 Lisitsyn N, Wigler M. Representational difference analysis in detection of genetic lesions in cancer. Methods in Enzymology. 254: 291-304. PMID 8531693 DOI: 10.1016/0076-6879(95)54021-0  1
1995 White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH. Multiple Ras functions can contribute to mammalian cell transformation. Cell. 80: 533-41. PMID 7867061 DOI: 10.1016/0092-8674(95)90507-3  1
1995 Lisitsyn NA, Lisitsina NM, Dalbagni G, Barker P, Sanchez CA, Gnarra J, Linehan WM, Reid BJ, Wigler MH. Comparative genomic analysis of tumors: detection of DNA losses and amplification. Proceedings of the National Academy of Sciences of the United States of America. 92: 151-5. PMID 7816807 DOI: 10.1073/pnas.92.1.151  1
1995 Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 92: 6180-4. PMID 7597098  1
1995 Jung V, Chen L, Hofmann SL, Wigler M, Powers S. Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins. Molecular and Cellular Biology. 15: 1333-42. PMID 7532279  1
1994 Xu HP, White M, Marcus S, Wigler M. Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Molecular and Cellular Biology. 14: 50-8. PMID 8264618  1
1994 Jung V, Wei W, Ballester R, Camonis J, Mi S, Van Aelst L, Wigler M, Broek D. Two types of RAS mutants that dominantly interfere with activators of RAS. Molecular and Cellular Biology. 14: 3707-18. PMID 8196614  1
1994 Lisitsyn NA, Segre JA, Kusumi K, Lisitsyn NM, Nadeau JH, Frankel WN, Wigler MH, Lander ES. Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis. Nature Genetics. 6: 57-63. PMID 8136836 DOI: 10.1038/ng0194-57  1
1994 Marcus S, Polverino A, Barr M, Wigler M. Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proceedings of the National Academy of Sciences of the United States of America. 91: 7762-6. PMID 8052657  1
1994 Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell. 79: 131-41. PMID 7923372 DOI: 10.1016/0092-8674(94)90406-5  1
1994 Lisitsyn NA, Leach FS, Vogelstein B, Wigler MH. Detection of genetic loss in tumors by representational difference analysis. Cold Spring Harbor Symposia On Quantitative Biology. 59: 585-7. PMID 7587116  1
1994 Van Aelst L, White MA, Wigler MH. Ras partners. Cold Spring Harbor Symposia On Quantitative Biology. 59: 181-6. PMID 7587068  1
1993 Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (New York, N.Y.). 260: 1338-43. PMID 8493579  1
1993 Neiman AM, Stevenson BJ, Xu HP, Sprague GF, Herskowitz I, Wigler M, Marcus S. Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Molecular Biology of the Cell. 4: 107-20. PMID 8443406  1
1993 Lisitsyn N, Lisitsyn N, Wigler M. Cloning the differences between two complex genomes. Science (New York, N.Y.). 259: 946-51. PMID 8438152  1
1993 Gutmann DH, Boguski M, Marchuk D, Wigler M, Collins FS, Ballester R. Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene. 8: 761-9. PMID 8437860  1
1993 Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J, Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Molecular and Cellular Biology. 13: 487-95. PMID 8417346  1
1993 Bolger G, Michaeli T, Martins T, St John T, Steiner B, Rodgers L, Riggs M, Wigler M, Ferguson K. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs. Molecular and Cellular Biology. 13: 6558-71. PMID 8413254  1
1993 Michaeli T, Bloom TJ, Martins T, Loughney K, Ferguson K, Riggs M, Rodgers L, Beavo JA, Wigler M. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. The Journal of Biological Chemistry. 268: 12925-32. PMID 8389765  1
1993 Van Aelst L, Barr M, Marcus S, Polverino A, Wigler M. Complex formation between RAS and RAF and other protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 90: 6213-7. PMID 8327501  1
1993 Marcus S, Wigler M, Xu HP, Ballester R, Kawamukai M, Polverino A. RAS function and protein kinase cascades. Ciba Foundation Symposium. 176: 53-61; discussion 61. PMID 8299425  1
1993 Ohlmeyer MH, Swanson RN, Dillard LW, Reader JC, Asouline G, Kobayashi R, Wigler M, Still WC. Complex synthetic chemical libraries indexed with molecular tags. Proceedings of the National Academy of Sciences of the United States of America. 90: 10922-6. PMID 7504286 DOI: 10.1073/pnas.90.23.10922  1
1992 Kawamukai M, Gerst J, Field J, Riggs M, Rodgers L, Wigler M, Young D. Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe. Molecular Biology of the Cell. 3: 167-80. PMID 1550959  1
1992 Xu HP, Rajavashisth T, Grewal N, Jung V, Riggs M, Rodgers L, Wigler M. A gene encoding a protein with seven zinc finger domains acts on the sexual differentiation pathways of Schizosaccharomyces pombe. Molecular Biology of the Cell. 3: 721-34. PMID 1515675  1
1992 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. Biotechnology (Reading, Mass.). 24: 444-52. PMID 1422052  1
1992 Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 89: 9831-5. PMID 1384061  1
1992 Gerst JE, Rodgers L, Riggs M, Wigler M. SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proceedings of the National Academy of Sciences of the United States of America. 89: 4338-42. PMID 1316605 DOI: 10.1073/pnas.89.10.4338  1
1991 Wang Y, Xu HP, Riggs M, Rodgers L, Wigler M. byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Molecular and Cellular Biology. 11: 3554-63. PMID 2046669  1
1991 Gerst JE, Ferguson K, Vojtek A, Wigler M, Field J. CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Molecular and Cellular Biology. 11: 1248-57. PMID 1996090  1
1991 Wang Y, Boguski M, Riggs M, Rodgers L, Wigler M. sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation. 2: 453-65. PMID 1883874  1
1991 Vojtek A, Haarer B, Field J, Gerst J, Pollard TD, Brown S, Wigler M. Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell. 66: 497-505. PMID 1868547 DOI: 10.1016/0092-8674(81)90013-1  1
1991 Young D, O'Neill K, Broek D, Wigler M. The adenylyl cyclase-encoding gene from Saccharomyces kluyveri. Gene. 102: 129-32. PMID 1864503 DOI: 10.1016/0378-1119(91)90551-L  1
1991 Kawamukai M, Ferguson K, Wigler M, Young D. Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation. 2: 155-64. PMID 1863602  1
1991 Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 88: 2913-7. PMID 1849280  1
1991 Daar I, Nebreda AR, Yew N, Sass P, Paules R, Santos E, Wigler M, Vande Woude GF. The ras oncoprotein and M-phase activity. Science (New York, N.Y.). 253: 74-6. PMID 1829549  1
1990 Field J, Xu HP, Michaeli T, Ballester R, Sass P, Wigler M, Colicelli J. Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. Science (New York, N.Y.). 247: 464-7. PMID 2405488  1
1990 Birchmeier C, O'Neill K, Riggs M, Wigler M. Characterization of ROS1 cDNA from a human glioblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 87: 4799-803. PMID 2352949  1
1990 Xu HP, Riggs M, Rodgers L, Wigler M. A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucleic Acids Research. 18: 5304. PMID 2205842  1
1990 Wigler MH. Oncoproteins. GAPs in understanding Ras. Nature. 346: 696-7. PMID 2201920 DOI: 10.1038/346696a0  1
1990 Field J, Vojtek A, Ballester R, Bolger G, Colicelli J, Ferguson K, Gerst J, Kataoka T, Michaeli T, Powers S, Riggs M, Rodgers L, Wieland I, Wheland B, Wigler M. Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein Cell. 61: 319-327. PMID 2184942 DOI: 10.1016/0092-8674(90)90812-S  1
1990 Wieland I, Bolger G, Asouline G, Wigler M. A method for difference cloning: gene amplification following subtractive hybridization. Proceedings of the National Academy of Sciences of the United States of America. 87: 2720-4. PMID 2138783  1
1990 Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins F. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell. 63: 851-9. PMID 2121371 DOI: 10.1016/0092-8674(90)90151-4  1
1990 Colicelli J, Field J, Ballester R, Chester N, Young D, Wigler M. Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Molecular and Cellular Biology. 10: 2539-43. PMID 2111437  1
1990 Xu HP, Wang Y, Riggs M, Rodgers L, Wigler M. Biological activity of the mammalian RAP genes in yeast. Cell Regulation. 1: 763-9. PMID 1983087  1
1989 Sharma S, Birchmeier C, Nikawa J, O'Neill K, Rodgers L, Wigler M. Characterization of the ros1-gene products expressed in human glioblastoma cell lines. Oncogene Research. 5: 91-100. PMID 2691958  1
1989 Michaeli T, Field J, Ballester R, O'Neill K, Wigler M. Mutants of H-ras that interfere with RAS effector function in Saccharomyces cerevisiae. The Embo Journal. 8: 3039-44. PMID 2684634  1
1989 Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. Genetic analysis of mammalian GAP expressed in yeast. Cell. 59: 681-6. PMID 2684416 DOI: 10.1016/0092-8674(89)90014-7  1
1989 Young D, Riggs M, Field J, Vojtek A, Broek D, Wigler M. The adenylyl cyclase gene from Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 86: 7989-93. PMID 2682634  1
1989 Powers S, O'Neill K, Wigler M. Dominant yeast and mammalian RAS mutants that interfere with the CDC25-dependent activation of wild-type RAS in Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 390-5. PMID 2651897  1
1989 Colicelli J, Birchmeier C, Michaeli T, O'Neill K, Riggs M, Wigler M. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 86: 3599-603. PMID 2542941  1
1988 Toda T, Cameron S, Sass P, Wigler M. SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes & Development. 2: 517-27. PMID 3290050  1
1988 Wigler M, Field J, Powers S, Broek D, Toda T, Cameron S, Nikawa J, Michaeli T, Colicelli J, Ferguson K. Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harbor Symposia On Quantitative Biology. 53: 649-55. PMID 3076094  1
1988 Cameron S, Levin L, Zoller M, Wigler M. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell. 53: 555-66. PMID 2836063 DOI: 10.1016/0092-8674(88)90572-7  1
1988 Levin LR, Kuret J, Johnson KE, Powers S, Cameron S, Michaeli T, Wigler M, Zoller MJ. A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science (New York, N.Y.). 240: 68-70. PMID 2832943  1
1988 Young D, O'Neill K, Jessell T, Wigler M. Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Proceedings of the National Academy of Sciences of the United States of America. 85: 5339-42. PMID 2455902  1
1988 Field J, Nikawa J, Broek D, MacDonald B, Rodgers L, Wilson IA, Lerner RA, Wigler M. Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Molecular and Cellular Biology. 8: 2159-65. PMID 2455217  1
1987 Broek D, Toda T, Michaeli T, Levin L, Birchmeier C, Zoller M, Powers S, Wigler M. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell. 48: 789-99. PMID 3545497 DOI: 10.1016/0092-8674(87)90076-6  1
1987 Rabin M, Birnbaum D, Young D, Birchmeier C, Wigler M, Ruddle FH. Human ros1 and mas1 oncogenes located in regions of chromosome 6 associated with tumor-specific rearrangements. Oncogene Research. 1: 169-78. PMID 3329713  1
1987 Field J, Broek D, Kataoka T, Wigler M. Guanine nucleotide activation of, and competition between, RAS proteins from Saccharomyces cerevisiae. Molecular and Cellular Biology. 7: 2128-33. PMID 3299060  1
1987 Toda T, Cameron S, Sass P, Zoller M, Scott JD, McMullen B, Hurwitz M, Krebs EG, Wigler M. Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Molecular and Cellular Biology. 7: 1371-7. PMID 3037314  1
1987 Johnson KE, Cameron S, Toda T, Wigler M, Zoller MJ. Expression in Escherichia coli of BCY1, the regulatory subunit of cyclic AMP-dependent protein kinase from Saccharomyces cerevisiae. Purification and characterization. The Journal of Biological Chemistry. 262: 8636-42. PMID 3036817  1
1987 Toda T, Cameron S, Sass P, Zoller M, Wigler M. Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell. 50: 277-87. PMID 3036373 DOI: 10.1016/0092-8674(87)90223-6  1
1987 Nikawa J, Cameron S, Toda T, Ferguson KM, Wigler M. Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes & Development. 1: 931-7. PMID 2828175  1
1987 Birchmeier C, Sharma S, Wigler M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 9270-4. PMID 2827175  1
1987 Nikawa J, Sass P, Wigler M. Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Molecular and Cellular Biology. 7: 3629-36. PMID 2824992  1
1986 Birchmeier C, Birnbaum D, Waitches G, Fasano O, Wigler M. Characterization of an activated human ros gene. Molecular and Cellular Biology. 6: 3109-16. PMID 3785223  1
1986 Young D, Waitches G, Birchmeier C, Fasano O, Wigler M. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell. 45: 711-9. PMID 3708691 DOI: 10.1016/0092-8674(86)90785-3  1
1986 Powers S, Michaelis S, Broek D, Santa Anna S, Field J, Herskowitz I, Wigler M. RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell. 47: 413-22. PMID 3533274 DOI: 10.1016/0092-8674(86)90598-2  1
1986 Birchmeier C, Young D, Wigler M. Characterization of two new human oncogenes. Cold Spring Harbor Symposia On Quantitative Biology. 51: 993-1000. PMID 3472773  1
1986 Toda T, Broek D, Field J, Michaeli T, Cameron S, Nikawa J, Sass P, Birchmeier C, Powers S, Wigler M. Exploring the function of RAS oncogenes by studying the yeast Saccharomyces cerevisiae. Princess Takamatsu Symposia. 17: 253-60. PMID 3332013  1
1986 Sass P, Field J, Nikawa J, Toda T, Wigler M. Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 83: 9303-7. PMID 3025832  1
1985 Gross M, Sweet RW, Sathe G, Yokoyama S, Fasano O, Goldfarb M, Wigler M, Rosenberg M. Purification and characterization of human H-ras proteins expressed in Escherichia coli. Molecular and Cellular Biology. 5: 1015-24. PMID 3923330  1
1985 Broek D, Samiy N, Fasano O, Fujiyama A, Tamanoi F, Northup J, Wigler M. Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell. 41: 763-9. PMID 3891097 DOI: 10.1016/S0092-8674(85)80057-X  1
1985 Birchmeier C, Broek D, Toda T, Powers S, Kataoka T, Wigler M. Conservation and divergence of RAS protein function during evolution. Cold Spring Harbor Symposia On Quantitative Biology. 50: 721-5. PMID 3007012  0.4
1985 Toda T, Uno I, Ishikawa T, Powers S, Kataoka T, Broek D, Cameron S, Broach J, Matsumoto K, Wigler M. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell. 40: 27-36. PMID 2981630 DOI: 10.1016/0092-8674(85)90305-8  1
1985 Kataoka T, Powers S, Cameron S, Fasano O, Goldfarb M, Broach J, Wigler M. Functional homology of mammalian and yeast RAS genes. Cell. 40: 19-26. PMID 2981628 DOI: 10.1016/0092-8674(85)90304-6  1
1985 Kataoka T, Broek D, Wigler M. DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell. 43: 493-505. PMID 2934138 DOI: 10.1016/0092-8674(85)90179-5  1
1985 Birchmeier C, Broek D, Wigler M. ras proteins can induce meiosis in Xenopus oocytes. Cell. 43: 615-21. PMID 2416466 DOI: 10.1016/0092-8674(85)90233-8  1
1984 Tamanoi F, Walsh M, Kataoka T, Wigler M. A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America. 81: 6924-8. PMID 6438624  1
1984 Powers S, Kataoka T, Fasano O, Goldfarb M, Strathern J, Broach J, Wigler M. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell. 36: 607-12. PMID 6365329 DOI: 10.1016/0092-8674(84)90340-4  1
1984 Fasano O, Aldrich T, Tamanoi F, Taparowsky E, Furth M, Wigler M. Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 81: 4008-12. PMID 6330729  1
1984 Kataoka T, Powers S, McGill C, Fasano O, Strathern J, Broach J, Wigler M. Genetic analysis of yeast RAS1 and RAS2 genes. Cell. 37: 437-45. PMID 6327067 DOI: 10.1016/0092-8674(84)90374-X  1
1984 Fasano O, Birnbaum D, Edlund L, Fogh J, Wigler M. New human transforming genes detected by a tumorigenicity assay. Molecular and Cellular Biology. 4: 1695-705. PMID 6092933  1
1983 Kwoh TJ, Zipser D, Wigler M. Mutational analysis of the cloned chicken thymidine kinase gene. Journal of Molecular and Applied Genetics. 2: 191-200. PMID 6875426  1
1983 Taparowsky E, Shimizu K, Goldfarb M, Wigler M. Structure and activation of the human N-ras gene. Cell. 34: 581-6. PMID 6616621 DOI: 10.1016/0092-8674(83)90390-2  1
1983 Barker D, McCoy M, Weinberg R, Goldfarb M, Wigler M, Burt R, Gardner E, White R. A test of the role of two oncogenes in inherited predisposition to colon cancer. Molecular Biology & Medicine. 1: 199-206. PMID 6594558  1
1983 Ryan J, Barker PE, Shimizu K, Wigler M, Ruddle FH. Chromosomal assignment of a family of human oncogenes. Proceedings of the National Academy of Sciences of the United States of America. 80: 4460-3. PMID 6576347  1
1983 Shimizu K, Goldfarb M, Suard Y, Perucho M, Li Y, Kamata T, Feramisco J, Stavnezer E, Fogh J, Wigler MH. Three human transforming genes are related to the viral ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America. 80: 2112-6. PMID 6572964  1
1983 Shimizu K, Birnbaum D, Ruley MA, Fasano O, Suard Y, Edlund L, Taparowsky E, Goldfarb M, Wigler M. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature. 304: 497-500. PMID 6308465 DOI: 10.1038/304497a0  1
1983 Fasano O, Taparowsky E, Fiddes J, Wigler M, Goldfarb M. Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. Journal of Molecular and Applied Genetics. 2: 173-80. PMID 6308118  1
1983 Shimizu K, Goldfarb M, Perucho M, Wigler M. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 80: 383-7. PMID 6300838  1
1982 Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature. 300: 762-5. PMID 7177195 DOI: 10.1038/300762a0  1
1982 Goldfarb M, Shimizu K, Perucho M, Wigler M. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature. 296: 404-9. PMID 7063039  1
1981 Wigler MH. The inheritance of methylation patterns in vertebrates. Cell. 24: 285-6. PMID 7195315  1
1981 Perucho M, Wigler M. Linkage and expression of foreign DNA in cultured animal cells. Cold Spring Harbor Symposia On Quantitative Biology. 45: 829-38. PMID 6942952  1
1981 Wigler M, Levy D, Perucho M. The somatic replication of DNA methylation. Cell. 24: 33-40. PMID 6263490 DOI: 10.1016/0092-8674(81)90498-0  1
1981 Perucho M, Goldfarb M, Shimizu K, Lama C, Fogh J, Wigler M. Human-tumor-derived cell lines contain common and different transforming genes. Cell. 27: 467-76. PMID 6101201 DOI: 10.1016/0092-8674(81)90388-3  1
1980 Perucho M, Hanahan D, Wigler M. Genetic and physical linkage of exogenous sequences in transformed cells. Cell. 22: 309-17. PMID 6253083  1
1980 Wigler M, Perucho M, Kurtz D, Dana S, Pellicer A, Axel R, Silverstein S. Transformation of mammalian cells with an amplifiable dominant-acting gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 3567-70. PMID 6251468 DOI: 10.1073/pnas.77.6.3567  1
1980 Hanahan D, Lane D, Lipsich L, Wigler M, Botchan M. Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell. 21: 127-39. PMID 6250708 DOI: 10.1016/0092-8674(80)90120-8  1
1980 Perucho M, Hanahan D, Lipsich L, Wigler M. Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature. 285: 207-10. PMID 6246445  1
1979 Wold B, Wigler M, Lacy E, Maniatis T, Silverstein S, Axel R. Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 76: 5684-8. PMID 293672  1
1979 Wigler M, Pellicer A, Silverstein S, Axel R, Urlaub G, Chasin L. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 1373-6. PMID 286319  1
1979 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell. 16: 777-85. PMID 222468 DOI: 10.1016/0092-8674(79)90093-X  1
1978 Wigler M, DeFeo D, Weinstein IB. Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Cancer Research. 38: 1434-7. PMID 639070  1
1978 Silverstein S, Wigler M, Pellicer A, Axel R. Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA. Iarc Scientific Publications. 501-8. PMID 221354  1
1978 Wigler M, Pellicer A, Silverstein S, Axel R. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell. 14: 725-31. PMID 210957 DOI: 10.1016/0092-8674(78)90254-4  1
1978 Pellicer A, Wigler M, Axel R, Silverstein S. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell. 14: 133-41. PMID 208776 DOI: 10.1016/0092-8674(78)90308-2  1
1977 Viaje A, Slaga TJ, Wigler M, Weinstein IB. Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator. Cancer Research. 37: 1530-6. PMID 856468  1
1977 Wigler M, Silverstein S, Lee LS, Pellicer A, Cheng Yc, Axel R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell. 11: 223-32. PMID 194704 DOI: 10.1016/0092-8674(77)90333-6  1
1977 Weinstein IB, Wigler M. Cell culture studies provide new information on tumour promoters Nature. 270: 659-660. DOI: 10.1038/270659a0  1
1976 Wigler M, Weinstein IB. Tumour promotor induces plasminogen activator. Nature. 259: 232-3. PMID 1250353 DOI: 10.1038/259232a0  1
1976 Wigler MH, Axel R. Nucleosomes in metaphase chromosomes. Nucleic Acids Research. 3: 1463-71. PMID 958895 DOI: 10.1093/nar/3.6.1463  1
1976 Wigler MH, Neugut AI, Weinstein IB. Enucleation of mammalian cells in suspension. Methods in Cell Biology. 14: 87-93. PMID 794633  1
1976 Weinstein IB, Wigler M, Stadler U. Analysis of the mechanism of chemical carcinogenesis in epithelial cell cultures Iarc (International Agency For Research On Cancer) Scientific Publications. 355-387.  1
1976 Weinstein IB, Wigler MH. Suppression of plasminogen activator: a novel property of glucocorticoids Clinical Research. 24: 463A.  1
1975 Wigler MH, Weinstein IB. A preparative method for obtaining enucleated mammalian cells. Biochemical and Biophysical Research Communications. 63: 669-74. PMID 1169063 DOI: 10.1016/S0006-291X(75)80436-0  1
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