Michael Wigler - Publications

Affiliations: 
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 
Area:
Cancer, Molecular Biology

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Yoon S, Munoz A, Yamrom B, Lee YH, Andrews P, Marks S, Wang Z, Reeves C, Winterkorn L, Krieger AM, Buja A, Pradhan K, Ronemus M, Baldwin KK, Levy D, ... Wigler M, et al. Rates of contributory de novo mutation in high and low-risk autism families. Communications Biology. 4: 1026. PMID 34471188 DOI: 10.1038/s42003-021-02533-z  0.699
2020 Miyabayashi K, Baker LA, Deschenes A, Traub B, Caligiuri G, Plenker D, Alagesan B, Belleau P, Li S, Kendall J, Jang GH, Kawaguchi RK, Somerville TDD, Tiriac H, Hwang CI, ... ... Wigler M, et al. Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes. Cancer Discovery. PMID 32703770 DOI: 10.1158/2159-8290.Cd-20-0133  0.32
2020 Baslan T, Kendall J, Volyanskyy K, McNamara K, Cox H, D'Italia S, Ambrosio F, Riggs M, Rodgers L, Leotta A, Song J, Mao Y, Wu J, Shah R, Gularte-Mérida R, ... ... Wigler M, et al. Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing. Elife. 9. PMID 32401198 DOI: 10.7554/Elife.51480  0.343
2020 Vasudevan A, Baruah PS, Smith JC, Wang Z, Sayles NM, Andrews P, Kendall J, Leu J, Chunduri NK, Levy D, Wigler M, Storchová Z, Sheltzer JM. Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Developmental Cell. 52: 413-428.e6. PMID 32097652 DOI: 10.1016/J.Devcel.2020.01.034  0.347
2019 Li S, Kendall J, Park S, Wang Z, Alexander J, Moffitt A, Ranade N, Danyko C, Gegenhuber B, Fischer S, Robinson BD, Lepor H, Tollkuhn J, Gillis J, Brouzes E, ... ... Wigler M, et al. Copolymerization of single cell nucleic acids into balls of acrylamide gel. Genome Research. PMID 31727682 DOI: 10.1101/Gr.253047.119  0.331
2017 Krasnitz A, Kendall J, Alexander J, Levy D, Wigler M. Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal. Trends in Molecular Medicine. PMID 28587830 DOI: 10.1016/J.Molmed.2017.05.005  0.337
2016 Fang H, Bergmann EA, Arora K, Vacic V, Zody MC, Iossifov I, O'Rawe JA, Wu Y, Jimenez Barron LT, Rosenbaum J, Ronemus M, Lee YH, Wang Z, Dikoglu E, Jobanputra V, ... ... Wigler M, et al. Indel variant analysis of short-read sequencing data with Scalpel. Nature Protocols. 11: 2529-2548. PMID 27854363 DOI: 10.1038/Nprot.2016.150  0.323
2015 Iossifov I, Levy D, Allen J, Ye K, Ronemus M, Lee YH, Yamrom B, Wigler M. Low load for disruptive mutations in autism genes and their biased transmission. Proceedings of the National Academy of Sciences of the United States of America. PMID 26401017 DOI: 10.1073/Pnas.1516376112  0.36
2015 Garvin T, Aboukhalil R, Kendall J, Baslan T, Atwal GS, Hicks J, Wigler M, Schatz MC. Interactive analysis and assessment of single-cell copy-number variations. Nature Methods. 12: 1058-60. PMID 26344043 DOI: 10.1038/Nmeth.3578  0.31
2015 Baslan T, Kendall J, Ward B, Cox H, Leotta A, Rodgers L, Riggs M, D'Italia S, Sun G, Yong M, Miskimen K, Gilmore H, Saborowski M, Dimitrova N, Krasnitz A, ... ... Wigler M, et al. Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research. 25: 714-24. PMID 25858951 DOI: 10.1101/Gr.188060.114  0.343
2015 Jayaprakash AD, Benson EK, Gone S, Liang R, Shim J, Lambertini L, Toloue MM, Wigler M, Aaronson SA, Sachidanandam R. Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Research. 43: 2177-87. PMID 25653158 DOI: 10.1093/Nar/Gkv052  0.339
2015 Rye IH, Lundin P, Månér S, Fjelldal R, Naume B, Wigler M, Hicks J, Børresen-Dale AL, Zetterberg A, Russnes HG. Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors. Genes, Chromosomes & Cancer. 54: 235-48. PMID 25546585 DOI: 10.1002/Gcc.22237  0.347
2014 Iossifov I, O'Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, Stessman HA, Witherspoon KT, Vives L, Patterson KE, Smith JD, Paeper B, Nickerson DA, Dea J, Dong S, ... ... Wigler M, et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature. 515: 216-21. PMID 25363768 DOI: 10.1038/Nature13908  0.32
2014 Dago AE, Stepansky A, Carlsson A, Luttgen M, Kendall J, Baslan T, Kolatkar A, Wigler M, Bethel K, Gross ME, Hicks J, Kuhn P. Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. Plos One. 9: e101777. PMID 25084170 DOI: 10.1371/Journal.Pone.0101777  0.366
2013 Krasnitz A, Sun G, Andrews P, Wigler M. Target inference from collections of genomic intervals. Proceedings of the National Academy of Sciences of the United States of America. 110: E2271-8. PMID 23744040 DOI: 10.1073/Pnas.1306909110  0.309
2013 Welsh A, Danila DC, Anand A, Kendall J, Sawyers CL, Fleisher M, Wigler M, Hicks JB, Scher HI. Genomic heterogeneity of circulating tumor cells in castration-resistant prostate cancer (CRPC) revealed by single-cell sequencing. Journal of Clinical Oncology. 31: 5030-5030. DOI: 10.1200/Jco.2013.31.15_Suppl.5030  0.347
2012 Stadler ZK, Esposito D, Shah S, Vijai J, Yamrom B, Levy D, Lee YH, Kendall J, Leotta A, Ronemus M, Hansen N, Sarrel K, Rau-Murthy R, Schrader K, Kauff N, ... ... Wigler M, et al. Rare de novo germline copy-number variation in testicular cancer. American Journal of Human Genetics. 91: 379-83. PMID 22863192 DOI: 10.1016/J.Ajhg.2012.06.019  0.303
2012 Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, ... ... Wigler M, et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America. 109: 8212-7. PMID 22566646 DOI: 10.1073/Pnas.1206062109  0.42
2012 Baslan T, Kendall J, Rodgers L, Cox H, Riggs M, Stepansky A, Troge J, Ravi K, Esposito D, Lakshmi B, Wigler M, Navin N, Hicks J. Genome-wide copy number analysis of single cells. Nature Protocols. 7: 1024-41. PMID 22555242 DOI: 10.1038/Nprot.2012.039  0.315
2012 Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee YH, Narzisi G, Leotta A, Kendall J, Grabowska E, Ma B, Marks S, Rodgers L, ... ... Wigler M, et al. De novo gene disruptions in children on the autistic spectrum. Neuron. 74: 285-99. PMID 22542183 DOI: 10.1016/J.Neuron.2012.04.009  0.366
2011 Levy D, Ronemus M, Yamrom B, Lee YH, Leotta A, Kendall J, Marks S, Lakshmi B, Pai D, Ye K, Buja A, Krieger A, Yoon S, Troge J, Rodgers L, ... ... Wigler M, et al. Rare de novo and transmitted copy-number variation in autistic spectrum disorders. Neuron. 70: 886-97. PMID 21658582 DOI: 10.1016/J.Neuron.2011.05.015  0.303
2011 Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D, Muthuswamy L, Krasnitz A, McCombie WR, Hicks J, Wigler M. Tumour evolution inferred by single-cell sequencing. Nature. 472: 90-4. PMID 21399628 DOI: 10.1038/Nature09807  0.32
2011 Kamalakaran S, Varadan V, Giercksky Russnes HE, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, KÃ¥resen R, Shama Prasada K, Rotti H, Rao R, Rao L, ... ... Wigler M, et al. DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology. 5: 77-92. PMID 21169070 DOI: 10.1016/J.Molonc.2010.11.002  0.363
2010 Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J, Riggs M, Eberling Y, Troge J, Grubor V, Levy D, Lundin P, MÃ¥nér S, Zetterberg A, Hicks J, ... Wigler M, et al. Inferring tumor progression from genomic heterogeneity. Genome Research. 20: 68-80. PMID 19903760 DOI: 10.1101/Gr.099622.109  0.37
2009 Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 16: 324-35. PMID 19800577 DOI: 10.1016/J.Ccr.2009.08.015  0.38
2009 Varadan V, Kamalakaran S, Russnes HG, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, Kåresen R, Lucito R, Wigler M, Dimitrova N, Naume B, et al. Genome-Wide DNA Methylation Profiles of Breast Tumors Reveal Loci Associated with Relapse Risk. Cancer Research. 69: 4046-4046. DOI: 10.1158/0008-5472.Sabcs-09-4046  0.332
2009 McArthur H, Brogi E, Patil S, Wigler M, Norton L, Hicks J, Hudis C. High Resolution Comparative Genomic Hybridization (CGH) Indicates That Genomic Profiles Are Very Heterogeneous for HER2 and TOP2A in FISH-Amplified Human Breast Cancer Specimens. Cancer Research. 69: 3165-3165. DOI: 10.1158/0008-5472.Sabcs-09-3165  0.306
2009 Kamalakaran S, Russnes HG, Janevski A, Levy D, Kendall J, Varadan V, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, Kåresen R, Lucito R, Wigler M, Dimitrova N, Naume B, et al. Subtype Dependent Alterations of the DNA Methylation Landscape in Breast Cancer. Cancer Research. 69: 1144-1144. DOI: 10.1158/0008-5472.Sabcs-09-1144  0.347
2008 Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 135: 852-64. PMID 19012953 DOI: 10.1016/J.Cell.2008.09.061  0.402
2008 Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development. 22: 1439-44. PMID 18519636 DOI: 10.1101/Gad.1672608  0.429
2008 Alarcón M, Abrahams BS, Stone JL, Duvall JA, Perederiy JV, Bomar JM, Sebat J, Wigler M, Martin CL, Ledbetter DH, Nelson SF, Cantor RM, Geschwind DH. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. American Journal of Human Genetics. 82: 150-9. PMID 18179893 DOI: 10.1016/J.Ajhg.2007.09.005  0.302
2007 Lucito R, Suresh S, Walter K, Pandey A, Lakshmi B, Krasnitz A, Sebat J, Wigler M, Klein AP, Brune K, Palmisano E, Maitra A, Goggins M, Hruban RH. Copy-number variants in patients with a strong family history of pancreatic cancer. Cancer Biology & Therapy. 6: 1592-9. PMID 17912030 DOI: 10.4161/Cbt.6.10.4725  0.354
2007 Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, ... ... Wigler M, et al. Strong association of de novo copy number mutations with autism. Science (New York, N.Y.). 316: 445-9. PMID 17363630 DOI: 10.1126/Science.1138659  0.316
2006 Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KC, Navin N, Hicks J, Mu D, Powers S, Wigler M, Botstein D. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 103: 19848-53. PMID 17167050 DOI: 10.1073/Pnas.0609635104  0.385
2006 Lakshmi B, Hall IM, Egan C, Alexander J, Leotta A, Healy J, Zender L, Spector MS, Xue W, Lowe SW, Wigler M, Lucito R. Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proceedings of the National Academy of Sciences of the United States of America. 103: 11234-9. PMID 16844783 DOI: 10.1073/Pnas.0602984103  0.327
2006 Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 125: 1253-67. PMID 16814713 DOI: 10.1016/J.Cell.2006.05.030  0.385
2006 Navin N, Grubor V, Hicks J, Leibu E, Thomas E, Troge J, Riggs M, Lundin P, MÃ¥nér S, Sebat J, Zetterberg A, Wigler M. PROBER: oligonucleotide FISH probe design software. Bioinformatics (Oxford, England). 22: 2437-8. PMID 16740623 DOI: 10.1093/Bioinformatics/Btl273  0.319
2004 Olshen AB, Venkatraman ES, Lucito R, Wigler M. Circular binary segmentation for the analysis of array-based DNA copy number data. Biostatistics (Oxford, England). 5: 557-72. PMID 15475419 DOI: 10.1093/Biostatistics/Kxh008  0.314
2004 Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, MÃ¥nér S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, ... ... Wigler M, et al. Large-scale copy number polymorphism in the human genome. Science (New York, N.Y.). 305: 525-8. PMID 15273396 DOI: 10.1126/Science.1098918  0.356
2004 Thomas EE, Srebro N, Sebat J, Navin N, Healy J, Mishra B, Wigler M. Distribution of short paired duplications in mammalian genomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10349-54. PMID 15240876 DOI: 10.1073/Pnas.0403727101  0.302
2003 Lucito R, Healy J, Alexander J, Reiner A, Esposito D, Chi M, Rodgers L, Brady A, Sebat J, Troge J, West JA, Rostan S, Nguyen KC, Powers S, Ye KQ, ... ... Wigler M, et al. Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Research. 13: 2291-305. PMID 12975311 DOI: 10.1101/Gr.1349003  0.321
2001 Scheffzek K, Grünewald P, Wohlgemuth S, Kabsch W, Tu H, Wigler M, Wittinghofer A, Herrmann C. The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure (London, England : 1993). 9: 1043-50. PMID 11709168 DOI: 10.1016/S0969-2126(01)00674-8  0.325
2001 Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH, Mittal V. Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 98: 13043-8. PMID 11687610 DOI: 10.1073/Pnas.221450598  0.765
2001 Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL. PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 4622-7. PMID 11274365 DOI: 10.1073/Pnas.081063798  0.749
2001 Lucito R, Alexander J, Rostan S, West J, Wigler M. Detection of gene copy number fluctuations with microarrays using genomic representations Nature Genetics. 27: 70-70. DOI: 10.1038/87190  0.327
2000 Lucito R, West J, Reiner A, Alexander J, Esposito D, Mishra B, Powers S, Norton L, Wigler M. Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Research. 10: 1726-36. PMID 11076858 DOI: 10.1101/Gr.138300  0.374
1999 Lucito R, West J, Reiner A, Alexander J, Yen C, Nakamura M, Wigler M. Application of representational microarrays to genetic analysis of primary tumours Nature Genetics. 23: 60-60. DOI: 10.1038/14359  0.338
1998 Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proceedings of the National Academy of Sciences of the United States of America. 95: 13513-8. PMID 9811831 DOI: 10.1073/Pnas.95.23.13513  0.765
1998 Lucito R, Nakimura M, West JA, Han Y, Chin K, Jensen K, McCombie R, Gray JW, Wigler M. Genetic analysis using genomic representations. Proceedings of the National Academy of Sciences of the United States of America. 95: 4487-92. PMID 9539764 DOI: 10.1073/Pnas.95.8.4487  0.384
1997 Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 94: 9052-7. PMID 9256433 DOI: 10.1073/Pnas.94.17.9052  0.755
1997 Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, ... Wigler MH, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science (New York, N.Y.). 275: 1943-7. PMID 9072974 DOI: 10.1126/Science.275.5308.1943  0.303
1994 Xu HP, White M, Marcus S, Wigler M. Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Molecular and Cellular Biology. 14: 50-8. PMID 8264618 DOI: 10.1128/Mcb.14.1.50  0.369
1993 Neiman AM, Stevenson BJ, Xu HP, Sprague GF, Herskowitz I, Wigler M, Marcus S. Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Molecular Biology of the Cell. 4: 107-20. PMID 8443406 DOI: 10.1091/Mbc.4.1.107  0.331
1992 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. Biotechnology (Reading, Mass.). 24: 444-52. PMID 1422052  0.706
1992 Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 89: 9831-5. PMID 1384061 DOI: 10.1073/Pnas.89.20.9831  0.345
1992 Gerst JE, Rodgers L, Riggs M, Wigler M. SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proceedings of the National Academy of Sciences of the United States of America. 89: 4338-42. PMID 1316605 DOI: 10.1073/Pnas.89.10.4338  0.364
1991 Gerst JE, Ferguson K, Vojtek A, Wigler M, Field J. CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Molecular and Cellular Biology. 11: 1248-57. PMID 1996090 DOI: 10.1128/Mcb.11.3.1248  0.327
1991 Vojtek A, Haarer B, Field J, Gerst J, Pollard TD, Brown S, Wigler M. Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell. 66: 497-505. PMID 1868547 DOI: 10.1016/0092-8674(81)90013-1  0.318
1991 Young D, O'Neill K, Broek D, Wigler M. The adenylyl cyclase-encoding gene from Saccharomyces kluyveri. Gene. 102: 129-32. PMID 1864503 DOI: 10.1016/0378-1119(91)90551-L  0.365
1991 Daar I, Nebreda AR, Yew N, Sass P, Paules R, Santos E, Wigler M, Vande Woude GF. The ras oncoprotein and M-phase activity. Science (New York, N.Y.). 253: 74-6. PMID 1829549 DOI: 10.1126/Science.1829549  0.304
1990 Field J, Xu HP, Michaeli T, Ballester R, Sass P, Wigler M, Colicelli J. Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. Science (New York, N.Y.). 247: 464-7. PMID 2405488 DOI: 10.1126/Science.2405488  0.354
1990 Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins F. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell. 63: 851-9. PMID 2121371 DOI: 10.1016/0092-8674(90)90151-4  0.38
1989 Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. Genetic analysis of mammalian GAP expressed in yeast. Cell. 59: 681-6. PMID 2684416 DOI: 10.1016/0092-8674(89)90014-7  0.356
1989 Colicelli J, Birchmeier C, Michaeli T, O'Neill K, Riggs M, Wigler M. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 86: 3599-603. PMID 2542941 DOI: 10.1073/Pnas.86.10.3599  0.401
1988 Cameron S, Levin L, Zoller M, Wigler M. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell. 53: 555-66. PMID 2836063 DOI: 10.1016/0092-8674(88)90572-7  0.353
1988 Young D, O'Neill K, Jessell T, Wigler M. Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Proceedings of the National Academy of Sciences of the United States of America. 85: 5339-42. PMID 2455902 DOI: 10.1073/Pnas.85.14.5339  0.332
1987 Broek D, Toda T, Michaeli T, Levin L, Birchmeier C, Zoller M, Powers S, Wigler M. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell. 48: 789-99. PMID 3545497 DOI: 10.1016/0092-8674(87)90076-6  0.433
1987 Birchmeier C, Sharma S, Wigler M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 9270-4. PMID 2827175 DOI: 10.1073/Pnas.84.24.9270  0.408
1986 Young D, Waitches G, Birchmeier C, Fasano O, Wigler M. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell. 45: 711-9. PMID 3708691 DOI: 10.1016/0092-8674(86)90785-3  0.392
1986 Powers S, Michaelis S, Broek D, Santa Anna S, Field J, Herskowitz I, Wigler M. RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell. 47: 413-22. PMID 3533274 DOI: 10.1016/0092-8674(86)90598-2  0.365
1985 Gross M, Sweet RW, Sathe G, Yokoyama S, Fasano O, Goldfarb M, Wigler M, Rosenberg M. Purification and characterization of human H-ras proteins expressed in Escherichia coli. Molecular and Cellular Biology. 5: 1015-24. PMID 3923330 DOI: 10.1128/Mcb.5.5.1015  0.519
1985 Broek D, Samiy N, Fasano O, Fujiyama A, Tamanoi F, Northup J, Wigler M. Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell. 41: 763-9. PMID 3891097 DOI: 10.1016/S0092-8674(85)80057-X  0.355
1985 Kataoka T, Powers S, Cameron S, Fasano O, Goldfarb M, Broach J, Wigler M. Functional homology of mammalian and yeast RAS genes. Cell. 40: 19-26. PMID 2981628 DOI: 10.1016/0092-8674(85)90304-6  0.559
1984 Tamanoi F, Walsh M, Kataoka T, Wigler M. A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America. 81: 6924-8. PMID 6438624 DOI: 10.1073/Pnas.81.22.6924  0.4
1984 Powers S, Kataoka T, Fasano O, Goldfarb M, Strathern J, Broach J, Wigler M. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell. 36: 607-12. PMID 6365329 DOI: 10.1016/0092-8674(84)90340-4  0.565
1984 Fasano O, Aldrich T, Tamanoi F, Taparowsky E, Furth M, Wigler M. Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 81: 4008-12. PMID 6330729 DOI: 10.1073/Pnas.81.13.4008  0.691
1984 Kataoka T, Powers S, McGill C, Fasano O, Strathern J, Broach J, Wigler M. Genetic analysis of yeast RAS1 and RAS2 genes. Cell. 37: 437-45. PMID 6327067 DOI: 10.1016/0092-8674(84)90374-X  0.307
1983 Taparowsky E, Shimizu K, Goldfarb M, Wigler M. Structure and activation of the human N-ras gene. Cell. 34: 581-6. PMID 6616621 DOI: 10.1016/0092-8674(83)90390-2  0.722
1983 Barker D, McCoy M, Weinberg R, Goldfarb M, Wigler M, Burt R, Gardner E, White R. A test of the role of two oncogenes in inherited predisposition to colon cancer. Molecular Biology & Medicine. 1: 199-206. PMID 6594558  0.5
1983 Shimizu K, Goldfarb M, Suard Y, Perucho M, Li Y, Kamata T, Feramisco J, Stavnezer E, Fogh J, Wigler MH. Three human transforming genes are related to the viral ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America. 80: 2112-6. PMID 6572964 DOI: 10.1073/Pnas.80.8.2112  0.523
1983 Shimizu K, Birnbaum D, Ruley MA, Fasano O, Suard Y, Edlund L, Taparowsky E, Goldfarb M, Wigler M. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature. 304: 497-500. PMID 6308465 DOI: 10.1038/304497A0  0.721
1983 Fasano O, Taparowsky E, Fiddes J, Wigler M, Goldfarb M. Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. Journal of Molecular and Applied Genetics. 2: 173-80. PMID 6308118  0.509
1983 Shimizu K, Goldfarb M, Perucho M, Wigler M. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 80: 383-7. PMID 6300838 DOI: 10.1073/Pnas.80.2.383  0.607
1982 Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature. 300: 762-5. PMID 7177195 DOI: 10.1038/300762A0  0.739
1982 Goldfarb M, Shimizu K, Perucho M, Wigler M. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature. 296: 404-9. PMID 7063039 DOI: 10.1038/296404A0  0.571
1981 Wigler M, Levy D, Perucho M. The somatic replication of DNA methylation. Cell. 24: 33-40. PMID 6263490 DOI: 10.1016/0092-8674(81)90498-0  0.334
1981 Perucho M, Goldfarb M, Shimizu K, Lama C, Fogh J, Wigler M. Human-tumor-derived cell lines contain common and different transforming genes. Cell. 27: 467-76. PMID 6101201 DOI: 10.1016/0092-8674(81)90388-3  0.616
1980 Perucho M, Hanahan D, Wigler M. Genetic and physical linkage of exogenous sequences in transformed cells. Cell. 22: 309-17. PMID 6253083 DOI: 10.1016/0092-8674(80)90178-6  0.341
1980 Wigler M, Perucho M, Kurtz D, Dana S, Pellicer A, Axel R, Silverstein S. Transformation of mammalian cells with an amplifiable dominant-acting gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 3567-70. PMID 6251468 DOI: 10.1073/pnas.77.6.3567  0.585
1980 Hanahan D, Lane D, Lipsich L, Wigler M, Botchan M. Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell. 21: 127-39. PMID 6250708 DOI: 10.1016/0092-8674(80)90120-8  0.385
1980 Perucho M, Hanahan D, Lipsich L, Wigler M. Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature. 285: 207-10. PMID 6246445 DOI: 10.1038/285207A0  0.404
1979 Wold B, Wigler M, Lacy E, Maniatis T, Silverstein S, Axel R. Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 76: 5684-8. PMID 293672 DOI: 10.1073/pnas.76.11.5684  0.709
1979 Wigler M, Pellicer A, Silverstein S, Axel R, Urlaub G, Chasin L. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 1373-6. PMID 286319 DOI: 10.1073/Pnas.76.3.1373  0.552
1979 Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell. 16: 777-85. PMID 222468 DOI: 10.1016/0092-8674(79)90093-X  0.732
1978 Wigler M, DeFeo D, Weinstein IB. Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Cancer Research. 38: 1434-7. PMID 639070  0.435
1978 Silverstein S, Wigler M, Pellicer A, Axel R. Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA. Iarc Scientific Publications. 501-8. PMID 221354  0.532
1978 Wigler M, Pellicer A, Silverstein S, Axel R. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell. 14: 725-31. PMID 210957 DOI: 10.1016/0092-8674(78)90254-4  0.613
1978 Pellicer A, Wigler M, Axel R, Silverstein S. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell. 14: 133-41. PMID 208776 DOI: 10.1016/0092-8674(78)90308-2  0.637
1977 Viaje A, Slaga TJ, Wigler M, Weinstein IB. Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator. Cancer Research. 37: 1530-6. PMID 856468  0.463
1977 Wigler M, Silverstein S, Lee LS, Pellicer A, Cheng Yc, Axel R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell. 11: 223-32. PMID 194704 DOI: 10.1016/0092-8674(77)90333-6  0.62
1977 Weinstein IB, Wigler M. Cell culture studies provide new information on tumour promoters Nature. 270: 659-660. DOI: 10.1038/270659A0  0.45
1976 Wigler M, Weinstein IB. Tumour promotor induces plasminogen activator. Nature. 259: 232-3. PMID 1250353 DOI: 10.1038/259232a0  0.354
1976 Wigler MH, Axel R. Nucleosomes in metaphase chromosomes. Nucleic Acids Research. 3: 1463-71. PMID 958895 DOI: 10.1093/nar/3.6.1463  0.464
1976 Wigler MH, Neugut AI, Weinstein IB. Enucleation of mammalian cells in suspension. Methods in Cell Biology. 14: 87-93. PMID 794633  0.412
1976 Weinstein IB, Wigler M, Stadler U. Analysis of the mechanism of chemical carcinogenesis in epithelial cell cultures Iarc (International Agency For Research On Cancer) Scientific Publications. 355-387.  0.387
1976 Weinstein IB, Wigler MH. Suppression of plasminogen activator: a novel property of glucocorticoids Clinical Research. 24: 463A.  0.353
1975 Wigler MH, Weinstein IB. A preparative method for obtaining enucleated mammalian cells. Biochemical and Biophysical Research Communications. 63: 669-74. PMID 1169063 DOI: 10.1016/S0006-291X(75)80436-0  0.4
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