J. Thomas Parsons - Publications

University of Virginia, Charlottesville, VA 
Signal transduction

148 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Newhook TE, Lindberg JM, Adair SJ, Kim AJ, Stelow EB, Rahma OE, Parsons JT, Bauer TW. Adjuvant Trametinib Delays the Outgrowth of Occult Pancreatic Cancer in a Mouse Model of Patient-Derived Liver Metastasis. Annals of Surgical Oncology. PMID 26847682 DOI: 10.1245/S10434-016-5116-4  1
2015 Bainbridge MN, Armstrong GN, Gramatges MM, Bertuch AA, Jhangiani SN, Doddapaneni H, Lewis L, Tombrello J, Tsavachidis S, Liu Y, Jalali A, Plon SE, Lau CC, Parsons DW, Claus EB, et al. Germline mutations in shelterin complex genes are associated with familial glioma. Journal of the National Cancer Institute. 107: 384. PMID 25482530 DOI: 10.1093/Jnci/Dju384  0.8
2014 Lindberg JM, Newhook TE, Adair SJ, Walters DM, Kim AJ, Stelow EB, Parsons JT, Bauer TW. Co-treatment with panitumumab and trastuzumab augments response to the MEK inhibitor trametinib in a patient-derived xenograft model of pancreatic cancer. Neoplasia (New York, N.Y.). 16: 562-71. PMID 25117978 DOI: 10.1016/j.neo.2014.06.004  1
2014 Reynolds AB, Kanner SB, Bouton AH, Schaller MD, Weed SA, Flynn DC, Parsons JT. SRChing for the substrates of Src. Oncogene. 33: 4537-47. PMID 24121272 DOI: 10.1038/Onc.2013.416  1
2013 Walters DM, Stokes JB, Adair SJ, Stelow EB, Borgman CA, Lowrey BT, Xin W, Blais EM, Lee JK, Papin JA, Parsons JT, Bauer TW. Clinical, molecular and genetic validation of a murine orthotopic xenograft model of pancreatic adenocarcinoma using fresh human specimens. Plos One. 8: e77065. PMID 24204737 DOI: 10.1371/Journal.Pone.0077065  1
2013 Maninová M, Klímová Z, Parsons JT, Weber MJ, Iwanicki MP, Vomastek T. The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. Journal of Molecular Biology. 425: 2039-55. PMID 23524135 DOI: 10.1016/J.Jmb.2013.02.034  1
2013 Walters DM, Lindberg JM, Adair SJ, Newhook TE, Cowan CR, Stokes JB, Borgman CA, Stelow EB, Lowrey BT, Chopivsky ME, Gilmer TM, Parsons JT, Bauer TW. Inhibition of the growth of patient-derived pancreatic cancer xenografts with the MEK inhibitor trametinib is augmented by combined treatment with the epidermal growth factor receptor/HER2 inhibitor lapatinib. Neoplasia (New York, N.Y.). 15: 143-55. PMID 23441129 DOI: 10.1593/neo.121712  1
2012 Lindberg JM, Walters DM, Adair SJ, Cowan CR, Stokes JB, Borgman CA, Stelow EB, Lowrey BT, Chopivsky ME, Parsons JT, Bauer TW. Acquired resistance to combination therapy with lapatinib and MEK 1/2 inhibitor GSK1120212 in an in vivo murine model of pancreatic cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 208. PMID 27983148 DOI: 10.1200/Jco.2012.30.4_Suppl.208  0.6
2012 Tilghman RW, Blais EM, Cowan CR, Sherman NE, Grigera PR, Jeffery ED, Fox JW, Blackman BR, Tschumperlin DJ, Papin JA, Parsons JT. Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis. Plos One. 7: e37231. PMID 22623999 DOI: 10.1371/Journal.Pone.0037231  1
2012 Grigera PR, Ma L, Borgman CA, Pinto AF, Sherman NE, Parsons JT, Fox JW. Mass spectrometric analysis identifies a cortactin-RCC2/TD60 interaction in mitotic cells Journal of Proteomics. 75: 2153-2159. PMID 22282019 DOI: 10.1016/j.jprot.2012.01.012  1
2012 Guerrero MS, Parsons JT, Bouton AH. Cas and NEDD9 Contribute to Tumor Progression through Dynamic Regulation of the Cytoskeleton Genes and Cancer. 3: 371-381. DOI: 10.1177/1947601912458585  1
2011 Stokes JB, Adair SJ, Slack-Davis JK, Walters DM, Tilghman RW, Hershey ED, Lowrey B, Thomas KS, Bouton AH, Hwang RF, Stelow EB, Parsons JT, Bauer TW. Inhibition of focal adhesion kinase by PF-562,271 inhibits the growth and metastasis of pancreatic cancer concomitant with altering the tumor microenvironment. Molecular Cancer Therapeutics. 10: 2135-45. PMID 21903606 DOI: 10.1158/1535-7163.Mct-11-0261  1
2010 Tilghman RW, Cowan CR, Mih JD, Koryakina Y, Gioeli D, Slack-Davis JK, Blackman BR, Tschumperlin DJ, Parsons JT. Matrix rigidity regulates cancer cell growth and cellular phenotype Plos One. 5. PMID 20886123 DOI: 10.1371/Journal.Pone.0012905  1
2010 Parsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nature Reviews. Molecular Cell Biology. 11: 633-43. PMID 20729930 DOI: 10.1038/Nrm2957  1
2009 Slack-Davis JK, Hershey ED, Theodorescu D, Frierson HF, Parsons JT. Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model Molecular Cancer Therapeutics. 8: 2470-2477. PMID 19671741 DOI: 10.1158/1535-7163.Mct-09-0262  1
2009 Bernaciak TM, Zareno J, Parsons JT, Silva CM. A novel role for signal transducer and activator of transcription 5b (STAT5b) in β1-integrin-mediated human breast cancer cell migration Breast Cancer Research. 11. PMID 19630967 DOI: 10.1186/Bcr2341  1
2009 Petzold T, Orr AW, Hahn C, Jhaveri KA, Parsons JT, Schwartz MA. Focal adhesion kinase modulates activation of NF-kappaB by flow in endothelial cells. American Journal of Physiology. Cell Physiology. 297: C814-22. PMID 19587216 DOI: 10.1152/Ajpcell.00226.2009  1
2008 Vomastek T, Iwanicki MP, Burack WR, Tiwari D, Kumar D, Parsons JT, Weber MJ, Nandicoori VK. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Molecular and Cellular Biology. 28: 6954-66. PMID 18794356 DOI: 10.1128/Mcb.00925-08  1
2008 Sayers RL, Sundberg-Smith LJ, Rojas M, Hayasaka H, Parsons JT, Mack CP, Taylor JM. FRNK expression promotes smooth muscle cell maturation during vascular development and after vascular injury Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 2115-2122. PMID 18787183 DOI: 10.1161/Atvbaha.108.175455  1
2008 Iwanicki MP, Vomastek T, Tilghman RW, Martin KH, Banerjee J, Wedegaertner PB, Parsons JT. FAK, PDZ-RhoGEF and ROCKII cooperate to regulate adhesion movement and trailing-edge retraction in fibroblasts. Journal of Cell Science. 121: 895-905. PMID 18303050 DOI: 10.1242/Jcs.020941  1
2008 Parsons JT, Slack-Davis J, Tilghman R, Roberts WG. Focal adhesion kinase: Targeting adhesion signaling pathways for therapeutic intervention Clinical Cancer Research. 14: 627-632. PMID 18245520 DOI: 10.1158/1078-0432.CCR-07-2220  1
2008 Tilghman RW, Parsons JT. Focal adhesion kinase as a regulator of cell tension in the progression of cancer Seminars in Cancer Biology. 18: 45-52. PMID 17928235 DOI: 10.1016/j.semcancer.2007.08.002  1
2007 Owen KA, Pixley FJ, Thomas KS, Vicente-Manzanares M, Ray BJ, Horwitz AF, Parsons JT, Beggs HE, Stanley ER, Bouton AH. Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. The Journal of Cell Biology. 179: 1275-87. PMID 18070912 DOI: 10.1083/Jcb.200708093  1
2007 Mayhew MW, Jeffery ED, Sherman NE, Nelson K, Polefrone JM, Pratt SJ, Shabanowitz J, Parsons JT, Fox JW, Hunt DF, Horwitz AF. Identification of phosphorylation sites in betaPIX and PAK1. Journal of Cell Science. 120: 3911-8. PMID 17989089 DOI: 10.1242/Jcs.008177  1
2007 Vomastek T, Iwanicki MP, Schaeffer HJ, Tarcsafalvi A, Parsons JT, Weber MJ. RACK1 targets the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to link integrin engagement with focal adhesion disassembly and cell motility. Molecular and Cellular Biology. 27: 8296-305. PMID 17908799 DOI: 10.1128/Mcb.00598-07  1
2007 Zhang X, Yuan Z, Zhang Y, Yong S, Salas-Burgos A, Koomen J, Olashaw N, Parsons JT, Yang XJ, Dent SR, Yao TP, Lane WS, Seto E. HDAC6 Modulates Cell Motility by Altering the Acetylation Level of Cortactin Molecular Cell. 27: 197-213. PMID 17643370 DOI: 10.1016/J.Molcel.2007.05.033  1
2007 Hayasaka H, Martin KH, Hershey ED, Parsons JT. Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene Journal of Cellular Biochemistry. 102: 947-954. PMID 17440961 DOI: 10.1002/jcb.21329  1
2007 Slack-Davis JK, Martin KH, Tilghman RW, Iwanicki M, Ung EJ, Autry C, Luzzio MJ, Cooper B, Kath JC, Roberts WG, Parsons JT. Cellular characterization of a novel focal adhesion kinase inhibitor Journal of Biological Chemistry. 282: 14845-14852. PMID 17395594 DOI: 10.1074/Jbc.M606695200  1
2006 Luxenburg C, Parsons JT, Addadi L, Geiger B. Involvement of the Src-cortactin pathway in podosome formation and turnover during polarization of cultured osteoclasts Journal of Cell Science. 119: 4878-4888. PMID 17105771 DOI: 10.1242/Jcs.03271  1
2006 Martin KH, Jeffery ED, Grigera PR, Shabanowitz J, Hunt DF, Parsons JT. Cortactin phosphorylation sites mapped by mass spectrometry. Journal of Cell Science. 119: 2851-3. PMID 16825425 DOI: 10.1242/jcs03034  1
2005 Grigera PR, Jeffery ED, Martin KH, Shabanowitz J, Hunt DF, Parsons JT. FAK phosphorylation sites mapped by mass spectrometry. Journal of Cell Science. 118: 4931-5. PMID 16254240 DOI: 10.1242/Jcs.02696  1
2005 Hayasaka H, Simon K, Hershey ED, Masumoto KH, Parsons JT. FRNK, the autonomously expressed C-terminal region of focal adhesion kinase, is uniquely regulated in vascular smooth muscle: Analysis of expression in transgenic mice Journal of Cellular Biochemistry. 95: 1248-1263. PMID 15962314 DOI: 10.1002/Jcb.20501  1
2005 Tilghman RW, Slack-Davis JK, Sergina N, Martin KH, Iwanicki M, Hershey ED, Beggs HE, Reichardt LF, Parsons JT. Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. Journal of Cell Science. 118: 2613-23. PMID 15914540 DOI: 10.1242/Jcs.02380  1
2005 Liu Y, Yerushalmi GM, Grigera PR, Parsons JT. Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling. The Journal of Biological Chemistry. 280: 8884-92. PMID 15632162 DOI: 10.1074/Jbc.M412200200  1
2005 Belsches-Jablonski AP, Demory ML, Parsons JT, Parsons SJ. The Src pathway as a therapeutic strategy Drug Discovery Today: Therapeutic Strategies. 2: 313-321. DOI: 10.1016/j.ddstr.2005.11.005  1
2004 Parsons SJ, Parsons JT. Src family kinases, key regulators of signal transduction. Oncogene. 23: 7906-9. PMID 15489908 DOI: 10.1038/sj.onc.1208160  1
2004 Bougnères L, Girardin SE, Weed SA, Karginov AV, Olivo-Marin JC, Parsons JT, Sansonetti PJ, Van Nhieu GT. Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells. The Journal of Cell Biology. 166: 225-35. PMID 15263018 DOI: 10.1083/Jcb.200402073  1
2004 Webb DJ, Donais K, Whitmore LA, Thomas SM, Turner CE, Parsons JT, Horwitz AF. FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nature Cell Biology. 6: 154-61. PMID 14743221 DOI: 10.1038/Ncb1094  1
2004 Slack-Davis JK, Parsons JT. Emerging views of integrin signaling: Implications for prostate cancer Journal of Cellular Biochemistry. 91: 41-46. PMID 14689580 DOI: 10.1002/Jcb.10665  1
2003 Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell migration: integrating signals from front to back. Science (New York, N.Y.). 302: 1704-9. PMID 14657486 DOI: 10.1126/Science.1092053  1
2003 Head JA, Jiang D, Li M, Zorn LJ, Schaefer EM, Parsons JT, Weed SA. Cortactin tyrosine phosphorylation requires Rac1 activity and association with the cortical actin cytoskeleton Molecular Biology of the Cell. 14: 3216-3229. PMID 12925758 DOI: 10.1091/mbc.E02-11-0753  1
2003 Hou P, Estrada L, Kinley AW, Parsons JT, Vojtek AB, Gorski JL. Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape Human Molecular Genetics. 12: 1981-1993. PMID 12913069 DOI: 10.1093/Hmg/Ddg209  1
2003 Slack-Davis JK, Eblen ST, Zecevic M, Boerner SA, Tarcsafalvi A, Diaz HB, Marshall MS, Weber MJ, Parsons JT, Catling AD. PAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activation. The Journal of Cell Biology. 162: 281-91. PMID 12876277 DOI: 10.1083/Jcb.200212141  1
2003 Parsons JT. Focal adhesion kinase: The first ten years Journal of Cell Science. 116: 1409-1416. PMID 12640026 DOI: 10.1242/jcs.00373  1
2003 Kinley AW, Weed SA, Weaver AM, Karginov AV, Bissonette E, Cooper JA, Parsons JT. Cortactin interacts with WIP in regulating Arp2/3 activation and membrane protrusion. Current Biology : Cb. 13: 384-93. PMID 12620186 DOI: 10.1016/S0960-9822(03)00107-6  1
2002 Parsons JT, Zetter B, Mohla S. Shifting paradigms in tumor metastasis: Challenges and opportunities Cancer Biology and Therapy. 1: 582-585. PMID 12496493 DOI: 10.4161/Cbt.1.5.226  1
2002 Horwitz AR, Watson N, Parsons JT. Breaking barriers through collaboration: the example of the Cell Migration Consortium. Genome Biology. 3: comment2011. PMID 12429055 DOI: 10.1186/Gb-2002-3-11-Comment2011  1
2002 Schafer DA, Weed SA, Binns D, Karginov AV, Parsons JT, Cooper JA. Dynamin2 and cortactin regulate actin assembly and filament organization. Current Biology : Cb. 12: 1852-7. PMID 12419186 DOI: 10.1016/S0960-9822(02)01228-9  1
2002 Rovin JD, Frierson HF, Ledinh W, Parsons JT, Adams RB. Expression of focal adhesion kinase in normal and pathologic human prostate tissues. The Prostate. 53: 124-32. PMID 12242727 DOI: 10.1002/Pros.10114  1
2002 Weaver AM, Heuser JE, Karginov AV, Lee WL, Parsons JT, Cooper JA. Interaction of cortactin and N-WASp with Arp2/3 complex. Current Biology : Cb. 12: 1270-8. PMID 12176354 DOI: 10.1016/S0960-9822(02)01035-7  1
2002 Liu Y, Loijens JC, Martin KH, Karginov AV, Parsons JT. The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Molecular Biology of the Cell. 13: 2147-56. PMID 12058076 DOI: 10.1091/Mbc.E02-01-0018  1
2002 Martin KH, Slack JK, Boerner SA, Martin CC, Parsons JT. Integrin connections map: To infinity and beyond Science. 296: 1652-1653. PMID 12040184 DOI: 10.1126/science.296.5573.1652  1
2002 Webb DJ, Parsons JT, Horwitz AF. Adhesion assembly, disassembly and turnover in migrating cells - Over and over and over again Nature Cell Biology. 4: E97-E100. PMID 11944043 DOI: 10.1038/Ncb0402-E97  1
2002 Martin KH, Boerner SA, Parsons JT. Regulation of focal adhesion targeting and inhibitory functions of the FAK related protein FRNK using a novel estrogen receptor "switch". Cell Motility and the Cytoskeleton. 51: 76-88. PMID 11921165 DOI: 10.1002/cm.10018  0.52
2001 Haskell MD, Slack JK, Parsons JT, Parsons SJ. c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes Chemical Reviews. 101: 2425-2440. PMID 11749381 DOI: 10.1021/Cr0002341  1
2001 Weed SA, Parsons JT. Cortactin: Coupling membrane dynamics to cortical actin assembly Oncogene. 20: 6418-6434. PMID 11607842 DOI: 10.1038/Sj.Onc.1204783  1
2001 Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E. Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase Biochemical Journal. 358: 407-414. PMID 11513739 DOI: 10.1042/Bj3580407  1
2001 Slack JK, Adams RB, Rovin JD, Bissonette EA, Stoker CE, Parsons JT. Alterations in the focal adhesion kinase/Src signal transduction pathway correlate with increased migratory capacity of prostate carcinoma cells. Oncogene. 20: 1152-63. PMID 11313859 DOI: 10.1038/Sj.Onc.1204208  1
2001 Weaver AM, Karginov AV, Kinley AW, Weed SA, Li Y, Parsons JT, Cooper JA. Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Current Biology : Cb. 11: 370-4. PMID 11267876 DOI: 10.1016/S0960-9822(01)00098-7  1
2001 Taylor JM, Mack CP, Nolan K, Regan CP, Owens GK, Parsons JT. Selective expression of an endogenous inhibitor of FAK regulates proliferation and migration of vascular smooth muscle cells Molecular and Cellular Biology. 21: 1565-1572. PMID 11238893 DOI: 10.1128/Mcb.21.5.1565-1572.2001  1
2001 Ma A, Richardson A, Schaefer EM, Parsons JT. Serine phosphorylation of focal adhesion kinase in interphase and mitosis: A possible role in modulating binding to p130Cas Molecular Biology of the Cell. 12: 1-12. PMID 11160818 DOI: 10.1091/Mbc.12.1.1  1
2000 Harte MT, Macklem M, Weidow CL, Parsons JT, Bouton AH. Identification of two focal adhesion targeting sequences in the adapter molecule p130(Cas). Biochimica Et Biophysica Acta. 1499: 34-48. PMID 11118637 DOI: 10.1016/S0167-4889(00)00104-X  1
2000 Parsons JT, Martin KH, Slack JK, Taylor JM, Weed SA. Focal Adhesion Kinase: A regulator of focal adhesion dynamics and cell movement Oncogene. 19: 5606-5613. PMID 11114741 DOI: 10.1038/Sj.Onc.1203877  1
2000 Weed SA, Karginov AV, Schafer DA, Weaver AM, Kinley AW, Cooper JA, Parsons JT. Cortactin localization to sites of actin assembly in lamellipodia requires interactions with F-actin and the Arp2/3 complex. The Journal of Cell Biology. 151: 29-40. PMID 11018051 DOI: 10.1083/Jcb.151.1.29  1
2000 Longenecker KL, Zhang B, Derewenda U, Sheffield PJ, Dauter Z, Parsons JT, Zheng Y, Derewenda ZS. Structure of the BH domain from Graf and its implications for Rho GTPase recognition Journal of Biological Chemistry. 275: 38605-38610. PMID 10982819 DOI: 10.1074/jbc.M007574200  1
2000 Taylor JM, Rovin JD, Parsons JT. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular cardiomyocytes Journal of Biological Chemistry. 275: 19250-19257. PMID 10749882 DOI: 10.1074/Jbc.M909099199  1
1999 Horwitz AR, Parsons JT. Cell migration--movin' on. Science (New York, N.Y.). 286: 1102-3. PMID 10610524 DOI: 10.1126/Science.286.5442.1102  1
1999 Schaller MD, Hildebrand JD, Parsons JT. Complex formation with focal adhesion kinase: A mechanism to regulate activity and subcellular localization of Src kinases Molecular Biology of the Cell. 10: 3489-3505. PMID 10512882 DOI: 10.1091/Mbc.10.10.3489  1
1999 Slack JK, Catling AD, Eblen ST, Weber MJ, Parsons JT. c-Raf-mediated inhibition of epidermal growth factor-stimulated cell migration. The Journal of Biological Chemistry. 274: 27177-84. PMID 10480934 DOI: 10.1074/jbc.274.38.27177  1
1999 Wahl RC, Hsu RY, Huff JL, Jelinek MA, Chen K, Courchesne P, Patterson SD, Parsons JT, Welcher AA. Chicken macrophage stimulating protein is a ligand of the receptor protein-tyrosine kinase Sea. The Journal of Biological Chemistry. 274: 26361-8. PMID 10473593 DOI: 10.1074/jbc.274.37.26361  1
1999 Nolan K, Lacoste J, Parsons JT. Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase. Molecular and Cellular Biology. 19: 6120-9. PMID 10454559 DOI: 10.1128/Mcb.19.9.6120  1
1999 Lakkakorpi PT, Nakamura I, Nagy RM, Parsons JT, Rodan GA, Duong LT. Stable association of PYK2 and p130(Cas) in osteoclasts and their co- localization in the sealing zone Journal of Biological Chemistry. 274: 4900-4907. PMID 9988732 DOI: 10.1074/jbc.274.8.4900  1
1999 Taylor JM, Macklem MM, Parsons JT. Cytoskeletal changes induced by GRAF, the GTPase regulator associated with focal adhesion kinase, are mediated by Rho Journal of Cell Science. 112: 231-242. PMID 9858476  1
1998 Lacoste J, Ma A, Parsons JT. Assay and purification and focal adhesion kinase. Methods in Enzymology. 298: 89-102. PMID 9751874 DOI: 10.1016/S0076-6879(98)98011-9  1
1998 Du Y, Weed SA, Xiong WC, Marshall TD, Parsons JT. Identification of a novel cortactin SH3 domain-binding protein and its localization to growth cones of cultured neurons. Molecular and Cellular Biology. 18: 5838-51. PMID 9742101 DOI: 10.1128/Mcb.18.10.5838  1
1998 Xiong WC, Macklem M, Parsons JT. Expression and characterization of splice variants of PYK2, a focal adhesion kinase-related protein. Journal of Cell Science. 111: 1981-91. PMID 9645946  1
1998 Taylor JM, Hildebrand JD, Mack CP, Cox ME, Parsons JT. Characterization of Graf, the GTPase-activating protein for Rho associated with focal adhesion kinase. Phosphorylation and possible regulation by mitogen-activated protein kinase Journal of Biological Chemistry. 273: 8063-8070. PMID 9525907 DOI: 10.1074/Jbc.273.14.8063  1
1998 Sheffield PJ, Derewenda U, Taylor J, Parsons JT, Derewenda ZS. Expression, purification and crystallization of a novel gtpase activating protein (GAP) associated with focal adhesion kinase Faseb Journal. 12: A1368.  1
1997 Taylor JM, Richardson A, Parsons JT. Modular domains of focal adhesion-associated proteins Current Topics in Microbiology and Immunology. 228: 135-163. PMID 9401205  1
1997 Richardson A, Malik RK, Hildebrand JD, Parsons JT. Inhibition of cell spreading by expression of the C-terminal domain of focal adhesion kinase (FAK) is rescued by coexpression of Src or catalytically inactive FAK: A role for paxillin tyrosine phosphorylation Molecular and Cellular Biology. 17: 6906-6914. PMID 9372922 DOI: 10.1128/MCB.17.12.6906  1
1997 Xiong WC, Parsons JT. Induction of apoptosis after expression of PYK2, a tyrosine kinase structurally related to focal adhesion kinase Journal of Cell Biology. 139: 529-539. PMID 9334354 DOI: 10.1083/Jcb.139.2.529  1
1997 Richardson A, Shannon JD, Adams RB, Schaller MD, Parsons J. Identification of integrin-stimulated sites of serine phosphorylation in FRNK, the separately expressed C-terminal domain of focal adhesion kinase: a potential role for protein kinase A. The Biochemical Journal. 324: 141-9. PMID 9164850 DOI: 10.1042/Bj3240141  1
1997 Parsons JT, Parsons SJ. Src family protein tyrosine kinases: Cooperating with growth factor and adhesion signaling pathways Current Opinion in Cell Biology. 9: 187-192. PMID 9069259 DOI: 10.1016/S0955-0674(97)80062-2  1
1996 Malik RK, Parsons JT. Integrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway Journal of Biological Chemistry. 271: 29785-29791. PMID 8939916 DOI: 10.1074/Jbc.271.47.29785  1
1996 Parsons JT. Integrin-mediated signalling: Regulation by protein tyrosine kinases and small GTP-binding proteins Current Opinion in Cell Biology. 8: 146-152. PMID 8791417 DOI: 10.1016/S0955-0674(96)80059-7  1
1996 Medico E, Mongiovi AM, Huff J, Jelinek MA, Follenzi A, Gaudino G, Parsons JT, Comoglio PM. The tyrosine kinase receptors ron and sea control "Scattering" and morphogenesis of liver progenitor cells in vitro Molecular Biology of the Cell. 7: 495-504. PMID 8730094  1
1996 Malik RK, Parsons JT. Integrin-mediated signaling in normal and malignant cells: A role of protein tyrosine kinases Biochimica Et Biophysica Acta - Reviews On Cancer. 1287: 73-76. PMID 8672530 DOI: 10.1016/0304-419X(96)00008-X  1
1996 Harte MT, Hildebrand JD, Burnham MR, Bouton AH, Parsons JT. p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase. The Journal of Biological Chemistry. 271: 13649-55. PMID 8662921 DOI: 10.1074/Jbc.271.23.13649  1
1996 Burnham MR, Harte MT, Richardson A, Parsons JT, Bouton AH. The identification of p130cas-binding proteins and their role in cellular transformation. Oncogene. 12: 2467-72. PMID 8649789  1
1996 Richardson A, Parsons JT. A mechanism for regulation of the adhesion-associated protein tyrosine kinase pp125FAK Nature. 380: 538-540. PMID 8606775 DOI: 10.1038/380538A0  1
1996 Huff JL, Jelinek MA, Jamieson TA, Parsons JT. Expression and maturation of the cellular sea receptor, a member of the hepatocyte growth factor (HGF) receptor family of protein tyrosine kinases Oncogene. 12: 299-307. PMID 8570207  1
1995 Richardson A, Parsons JT. Signal transduction through integrins: A central role for focal adhesion kinase ? Bioessays. 17: 229-236. PMID 7748177 DOI: 10.1002/Bies.950170309  1
1995 Schaller MD, Otey CA, Hildebrand JD, Parsons JT. Focal adhesion kinase and paxillin bind to peptides mimicking β integrin cytoplasmic domains Journal of Cell Biology. 130: 1181-1187. PMID 7657702 DOI: 10.1083/Jcb.130.5.1181  1
1995 Chen HC, Appeddu PA, Parsons JT, Hildebrand JD, Schaller MD, Guan JL. Interaction of focal adhesion kinase with cytoskeletal protein talin Journal of Biological Chemistry. 270: 16995-16999. PMID 7622520 DOI: 10.1074/Jbc.270.28.16995  1
1995 Hildebrand JD, Schaller MD, Parsons JT. Paxillin, a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase Molecular Biology of the Cell. 6: 637-647. PMID 7579684 DOI: 10.1091/Mbc.6.6.637  1
1995 Petch LA, Bockholt SM, Bouton A, Parsons JT, Burridge K. Adhesion-induced tyrosine phosphorylation of the p130 src substrate. Journal of Cell Science. 108: 1371-9. PMID 7542255  1
1995 Schaller MD, Parsons JT. pp125FAK-dependent tyrosine phosphorylation of paxillin creates a high-affinity binding site for Crk Molecular and Cellular Biology. 15: 2635-2645. PMID 7537852 DOI: 10.1128/Mcb.15.5.2635  1
1994 Parsons JT, Schaller MD, Hildebrand J, Leu TH, Richardson A, Otey C. Focal adhesion kinase: structure and signalling. Journal of Cell Science. Supplement. 18: 109-13. PMID 7883785 DOI: 10.1242/Jcs.1994.Supplement_18.16  1
1994 Schaller MD, Thomas Parsons J. Focal adhesion kinase and associated proteins Current Opinion in Cell Biology. 6: 705-710. PMID 7833050 DOI: 10.1016/0955-0674(94)90097-3  0.52
1994 Miglarese MR, Mannion-Henderson J, Wu H, Parsons JT, Bender TP. The protein tyrosine kinase substrate cortactin is differentially expressed in murine B lymphoid tumors Oncogene. 9: 1989-1997. PMID 7516062  1
1994 Marengere LE, Songyang Z, Gish GD, Schaller MD, Parsons JT, Stern MJ, Cantley LC, Pawson T. SH2 domain specificity and activity modified by a single residue. Nature. 369: 502-5. PMID 7515480 DOI: 10.1038/369502A0  1
1994 Faris M, Gaskin F, Parsons JT, Fu SM. CD40 signaling pathway: Anti-CD40 monoclonal antibody induces rapid dephosphorylation and phosphorylation of tyrosine-phosphorylated proteins including protein tyrosine kinase Lyn, Fyn, and Syk and the appearance of a 28-kD tyrosine phosphorylated protein Journal of Experimental Medicine. 179: 1923-1931. PMID 7515102  1
1994 Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors Journal of Biological Chemistry. 269: 14738-14745. PMID 7514181  1
1994 Schaller MD, Hildebrand JD, Shannon JD, Fox JW, Vines RR, Parsons JT. Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src Molecular and Cellular Biology. 14: 1680-1688. PMID 7509446 DOI: 10.1128/Mcb.14.3.1680  1
1994 Cobb BS, Schaller MD, Leu TH, Parsons JT. Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Molecular and Cellular Biology. 14: 147-55. PMID 7505391 DOI: 10.1128/Mcb.14.1.147  1
1993 Schaller MD, Bouton AH, Flynn DC, Parsons JT. Identification and characterization of novel substrates for protein tyrosine kinases Progress in Nucleic Acid Research and Molecular Biology. 44: 205-227. PMID 8434124 DOI: 10.1016/S0079-6603(08)60221-4  1
1993 Schaller MD, Borgman CA, Parsons JT. Autonomous Expression of a Noncatalytic Domain of the Focal Adhesion-Associated Protein Tyrosine Kinase pp125FAK Molecular and Cellular Biology. 13: 785-791. PMID 8423801 DOI: 10.1128/Mcb.13.2.785  1
1993 Huff JL, Jelinek MA, Borgman CA, Lansing TJ, Parsons JT. The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptor Proceedings of the National Academy of Sciences of the United States of America. 90: 6140-6144. PMID 8392188 DOI: 10.1073/PNAS.90.13.6140  1
1993 Flynn DC, Leu TH, Reynolds AB, Parsons JT. Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Molecular and Cellular Biology. 13: 7892-900. PMID 8247004 DOI: 10.1128/Mcb.13.12.7892  1
1993 Hildebrand JD, Schaller MD, Parsons JT. Identification of sequences required for the efficient localization of the Focal Adhesion Kinase, pp125FAK, to cellular focal adhesions Journal of Cell Biology. 123: 993-1005. PMID 8227154 DOI: 10.1083/Jcb.123.4.993  1
1993 Wu H, Parsons JT. Cortactin, an 80/85-kilodalton pp60src substrate, is a filamentous actin-Binding protein enriched in the cell cortex Journal of Cell Biology. 120: 1417-1426. PMID 7680654 DOI: 10.1083/JCB.120.6.1417  1
1993 Schaller MD, Parsons JT. Focal adhesion kinase: an integrin-linked protein tyrosine kinase Trends in Cell Biology. 3: 258-262. DOI: 10.1016/0962-8924(93)90053-4  1
1992 Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets Journal of Cell Biology. 119: 905-912. PMID 1385445 DOI: 10.1083/Jcb.119.4.905  1
1992 Farina SF, Huff JL, Parsons JT. Mutations within the 5′ half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages Journal of Virology. 66: 2698-2708. PMID 1313895 DOI: 10.1128/JVI.66.5.2698-2708.1992  1
1992 Ely CM, Parsons SJ, Parsons JT. Immunological methods for the detection of phosphotyrosine-containing proteins in neural tissues Neuroprotocols. 1: 177-184. DOI: 10.1016/1058-6741(92)90026-T  1
1991 Cobb BS, Payne DM, Reynolds AB, Parsons JT. Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527). Molecular and Cellular Biology. 11: 5832-8. PMID 1719372 DOI: 10.1128/Mcb.11.12.5832  1
1991 Kanner SB, Reynolds AB, Wang HC, Vines RR, Parsons JT. The SH2 and SH3 domains of pp60src direct stable association with tyrosine phosphorylated proteins p130 and p110. The Embo Journal. 10: 1689-98. PMID 1710979 DOI: 10.1002/J.1460-2075.1991.Tb07693.X  1
1991 Bouton AH, Kanner SB, Vines RR, Parsons JT. Tyrosine phosphorylation of three cellular proteins correlates with transformation of rat 1 cells by pp60(src) Molecular Carcinogenesis. 4: 145-152. PMID 1710464  1
1991 Bouton AH, Kanner SB, Vines RR, Wang HCR, Gibbs JB, Parsons JT. Transformation by pp6Qsrc or Stimulation of Cells with Epidermal Growth Factor Induces the Stable Association of Tyrosine-Phosphorylated Cellular Proteins with GTPase-Activating Protein Molecular and Cellular Biology. 11: 945-953. PMID 1703633 DOI: 10.1128/Mcb.11.2.945  1
1991 Kanner SB, Reynolds AB, Parsons JT. Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells. Molecular and Cellular Biology. 11: 713-20. PMID 1703631 DOI: 10.1128/Mcb.11.2.713  1
1990 Kanner SB, Reynolds AB, Vines RR, Parsons JT. Monoclonal antibodies to individual tyrosine-phosphorylated protein substrates of oncogene-encoded tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 87: 3328-32. PMID 2110361 DOI: 10.1073/Pnas.87.9.3328  1
1989 Wang HCR, Parsons JT. Deletions and insertions within an amino-terminal domain of pp60(v-src) inactivate transformation and modulate membrane stability Journal of Virology. 63: 291-302. PMID 2535735 DOI: 10.1128/JVI.63.1.291-302.1989  1
1989 Parsons JT, Weber MJ. Genetics of src: structure and functional organization of a protein tyrosine kinase Current Topics in Microbiology and Immunology. 147: 79-127. PMID 2482802 DOI: 10.1007/978-3-642-74697-0_3  1
1989 Reynolds AB, Kanner SB, Wang HCR, Parsons JT. Stable association of activated pp60(src) with two tyrosine-phosphorylated cellular proteins Molecular and Cellular Biology. 9: 3951-3958. PMID 2476666 DOI: 10.1128/Mcb.9.9.3951  1
1989 Wilson LK, Luttrell DK, Parsons JT, Parsons SJ. pp60(c-src) tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-src Molecular and Cellular Biology. 9: 1536-1544. PMID 2471064 DOI: 10.1128/Mcb.9.4.1536  1
1989 Reynolds AB, Roesel DJ, Kanner SB, Parsons JT. Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene Molecular and Cellular Biology. 9: 629-638. PMID 2469003 DOI: 10.1128/Mcb.9.2.629  1
1987 McCarley DJ, Parsons JT, Benjamin DC, Parsons SJ. Inhibition of the tyrosine kinase activity of v-src, v-fgr, and v-yes gene products by a monoclonal antibody which binds both amino and carboxy peptide fragments of pp60(v-src) Journal of Virology. 61: 1927-1937. PMID 2437325  1
1986 Morgan JH, Parsons JT. Characterization of c-myc proteins from avian bursal lymphoma cell lines Virology. 150: 178-186. PMID 3513434 DOI: 10.1016/0042-6822(86)90277-1  1
1986 Heaney ML, Pierce J, Parsons JT. Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: Biological activity and intracellular localization of structurally altered proteins Journal of Virology. 60: 167-176. PMID 3018283 DOI: 10.1128/JVI.60.1.167-176.1986  1
1986 Parsons SJ, McCarley DJ, Raymond VW, Parsons JT. Localization of conserved and nonconserved epitopes within the Rous sarcoma virus-encoded src protein Journal of Virology. 59: 755-758. PMID 2426472  1
1985 Morgan JH, Parsons JT, Papas TS. Isolation of antibodies specific for avian viral and cellular myc proteins Journal of the National Cancer Institute. 75: 937-947. PMID 2997537 DOI: 10.1093/jnci/75.5.937  1
1985 Wilkerson VW, Bryant DL, Parsons JT. Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation Journal of Virology. 55: 314-321. PMID 2991557 DOI: 10.1128/JVI.55.2.314-321.1985  1
1985 Chen WT, Chen JM, Parsons SJ, Parsons JT. Local degradation of fibronectin at sites of expression of the transforming gene product pp60src Nature. 316: 156-158. PMID 2989711 DOI: 10.1038/316156a0  1
1984 Bryant DL, Parsons JT. Amino acid alterations within a highly conserved region of the rous sarcoma virus src gene product pp60(src) inactivative tyrosine protein kinase activity Molecular and Cellular Biology. 4: 862-866. PMID 6328273 DOI: 10.1128/MCB.4.5.862  1
1984 Parsons SJ, Wilson LD, Ely CM, Parsons JT, Benjamin DC. Monoclonal antibodies specific for the virion polypeptide, p27, of avian retroviruses Hybridoma. 3: 25-31. PMID 6205983 DOI: 10.1089/Hyb.1984.3.25  1
1984 Parsons SJ, McCarley DJ, Ely CM, Benjamin DC, Parsons JT. Monoclonal antibodies to Rous sarcoma virus pp60(src) react with enzymatically active cellular pp60(src) of avian and mammalian origin Journal of Virology. 51: 272-282. PMID 6205164  1
1983 Bryant D, Parsons JT. Site-directed point mutation in the src gene of Rous sarcoma virus results in an inactive src gene product Journal of Virology. 45: 1211-1216. PMID 6300458 DOI: 10.1128/JVI.45.3.1211-1216.1983  1
1983 Parsons SJ, McCarley DJ, Ely CM, Benjamin DC, Parsons JT. Isolation and partial characterization of a monoclonal antibody to the Rous sarcoma virus transforming protein pp60(src) Journal of Virology. 45: 1190-1194. PMID 6187941  1
1982 Bryant D, Parsons JT. Site-directed mutagenesis of the src gene of Rous sarcoma virus: Construction and characterization of a deletion mutant temperature sensitive for transformation Journal of Virology. 44: 683-691. PMID 6292526 DOI: 10.1128/Jvi.44.2.683-691.1982  1
1982 Gilmer TM, Parsons JT, Erikson RL. Construction of plasmids for expression of Rous sarcoma virus transforming protein, p60(smc), in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 79: 2152-2156. PMID 6285367  1
1981 Omer Ch. A, Parsons JT, Faras AJ. Direct proof of the 5' to 3' transcriptional jump during reverse transcription of the avian retrovirus genome by DNA sequencing Journal of Virology. 38: 398-402. PMID 6165832 DOI: 10.1128/Jvi.38.1.398-402.1981  1
1980 Highfield PE, Rafield LF, Gilmer TM, Parsons JT. Molecular cloning of avian sarcoma virus closed circular DNA: Structural and biological characterization of three recombinant clones Journal of Virology. 36: 271-279. PMID 6255211 DOI: 10.1128/JVI.36.1.271-279.1980  1
1980 Collins CJ, Boettiger D, Green TL, Burgess MB, Devlin H, Parsons JT. Arrangement of integrated avian sarcoma virus DNA sequences within the cellular genomes of transformed and revertant mammalian cells. Journal of Virology. 33: 760-8. PMID 6251247 DOI: 10.1128/Jvi.33.2.760-768.1980  1
1979 Parsons SJ, Riley SC, Mullen EE, Brock EJ, Benjamin DC, Kuehl WM, Parsons JT. Immune response to the src gene product in mice bearing tumors induced by injection of avian sarcoma virus-transformed mouse cells Journal of Virology. 32: 40-46. PMID 232185  1
1979 Gilmer TM, Parsons JT. Analysis of cellular integration sites in avian sarcoma virus-infected duck embryo cells Journal of Virology. 32: 762-769. PMID 229265 DOI: 10.1128/JVI.32.3.762-769.1979  1
1978 Parsons JT, Lewis P, Dierks P. Purification of virus-specific RNA from chicken cells infected with avian sarcoma virus: Identification of genome-length and subgenome-length viral RNAs Journal of Virology. 27: 227-238. PMID 211252 DOI: 10.1128/JVI.27.1.227-238.1978  1
1977 Collins CJ, Parsons JT. Integration of avian sarcoma virus DNA sequences in transformed mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 74: 4301-5. PMID 200912 DOI: 10.1073/PNAS.74.10.4301  1
1977 Emerson SU, Dierks PM, Parsons JT. In vitro synthesis of a unique RNA species by a T particle of vesicular stomatitis virus Journal of Virology. 23: 708-716. PMID 197268 DOI: 10.1128/JVI.23.3.708-716.1977  1
Show low-probability matches.