| Year |
Citation |
Score |
| 2021 |
Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA. 5-HT receptor- and M muscarinic acetylcholine receptor-mediated activation of Gα in postmortem dorsolateral prefrontal cortex of opiate addicts. Pharmacological Reports : Pr. 73: 1155-1163. PMID 33835465 DOI: 10.1007/s43440-021-00248-w |
0.33 |
|
| 2020 |
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, de Jonghe S, Daelemans D, Naesens L, Brea J, et al. Correction to Bicyclic α-Iminophosphonates as High Affinity Imidazoline I Receptor Ligands for Alzheimer's Disease. Journal of Medicinal Chemistry. PMID 32924503 DOI: 10.1021/Acs.Jmedchem.0C01324 |
0.338 |
|
| 2020 |
Salort G, Hernández-Hernández E, García-Fuster MJ, García-Sevilla JA. Regulation of cannabinoid CB1 and CB2 receptors, neuroprotective mTOR and pro-apoptotic JNK1/2 kinases in postmortem prefrontal cortex of subjects with major depressive disorder. Journal of Affective Disorders. 276: 626-635. PMID 32871695 DOI: 10.1016/J.Jad.2020.07.074 |
0.396 |
|
| 2020 |
Hernández-Hernández E, García-Sevilla JA, García-Fuster MJ. Exploring the antidepressant-like potential of the selective I2-imidazoline receptor ligand LSL 60101 in adult male rats. Pharmacological Reports. 1-8. PMID 32748254 DOI: 10.1007/S43440-020-00148-5 |
0.401 |
|
| 2020 |
Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA. Fundamental features of receptor-mediated Gαi/o activation in human prefrontal cortical membranes: A postmortem study. Brain Research. 1747: 147032. PMID 32745659 DOI: 10.1016/J.Brainres.2020.147032 |
0.445 |
|
| 2020 |
Escolano C, Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, De Jonghe S, Daelemans D, Naesens L, et al. Bicyclic -iminophosphonates as highly affinity imidazoline I2 receptor ligands for Alzheimer's Disease. Journal of Medicinal Chemistry. PMID 32150414 DOI: 10.1021/Acs.Jmedchem.9B02080 |
0.379 |
|
| 2020 |
Bousquet P, Hudson A, García-Sevilla JA, Li JX. Imidazoline Receptor System: The Past, the Present, and the Future. Pharmacological Reviews. 72: 50-79. PMID 31819014 DOI: 10.1124/Pr.118.016311 |
0.397 |
|
| 2020 |
Odagaki Y, Kinoshita M, Meana JJ, Callado LF, García-Sevilla JA. Functional coupling of M1 muscarinic acetylcholine receptor to Gαq/11 in dorsolateral prefrontal cortex from patients with psychiatric disorders: a postmortem study. European Archives of Psychiatry and Clinical Neuroscience. 270: 869-880. PMID 31807862 DOI: 10.1007/S00406-019-01088-9 |
0.34 |
|
| 2020 |
Abás S, Rodríguez-Arévalo S, Bagán A, Griñán-Ferré C, Vasilopoulou F, Brocos-Mosquera I, Muguruza C, Pérez B, Molins E, Luque FJ, Pérez-Lozano P, Jonghe Sd, Daelemans D, Naesens L, Brea J, et al. Bicyclic α‑Iminophosphonatesas HighAffinity Imidazoline I2 Receptor Ligands for Alzheimer’sDisease Journal of Medicinal Chemistry. DOI: 10.1021/Acs.Jmedchem.9B02080.S001 |
0.398 |
|
| 2019 |
Griñán-Ferré C, Vasilopoulou F, Abás S, Rodríguez-Arévalo S, Bagán A, Sureda FX, Pérez B, Callado LF, García-Sevilla JA, García-Fuster MJ, Escolano C, Pallàs M. Behavioral and Cognitive Improvement Induced by Novel Imidazoline I2 Receptor Ligands in Female SAMP8 Mice. Neurotherapeutics. 16: 416-431. PMID 30460457 DOI: 10.1007/S13311-018-00681-5 |
0.371 |
|
| 2019 |
Salort G, Álvaro-Bartolomé M, García-Sevilla JA. Pentobarbital and other anesthetic agents induce opposite regulations of MAP kinases p-MEK and p-ERK, and upregulate p-FADD/FADD neuroplastic index in brain during hypnotic states in mice Neurochemistry International. 122: 59-72. PMID 30423425 DOI: 10.1016/J.Neuint.2018.11.008 |
0.389 |
|
| 2019 |
Salort G, Álvaro-Bartolomé M, García-Sevilla JA. Pentobarbital-induced sleep upregulates the survival p-FADD/FADD ratio in mouse brain cortex European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.800 |
0.334 |
|
| 2019 |
Odagaki Y, Kinoshita M, Ota T, Meana JJ, Callado LF, Garcia-Sevilla JA. 5-HT2A receptor- and M1 muscarinic acetylcholine receptor-mediated Galpha(q) signalling in patients with psychiatric disorders European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2018.11.1015 |
0.344 |
|
| 2018 |
Odagaki Y, Kinoshita M, Ota T, Javier Meana J, Callado LF, García-Sevilla JA. Optimization and Pharmacological Characterization of Receptor-Mediated G Activation in Postmortem Human Prefrontal Cortex. Basic & Clinical Pharmacology & Toxicology. PMID 30507034 DOI: 10.1111/bcpt.13183 |
0.356 |
|
| 2018 |
Salort G, Álvaro-Bartolomé M, García-Sevilla JA. Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABA receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry. PMID 30003929 DOI: 10.1016/J.Pnpbp.2018.07.006 |
0.406 |
|
| 2018 |
Odagaki Y, Kinoshita M, Ota T, Meana JJ, Callado LF, Matsuoka I, García-Sevilla JA. Functional coupling between adenosine Areceptors and G-proteins in rat and postmortem human brain membranes determined with conventional guanosine-5'-O-(3-[S]thio)triphosphate ([S]GTPγS) binding or [S]GTPγS/immunoprecipitation assay. Purinergic Signalling. PMID 29492786 DOI: 10.1007/S11302-018-9603-X |
0.4 |
|
| 2018 |
Escolano C, Abas S, Rodriguez-Arevalo S, Bagan A, Pallas M, Griñan-Ferre C, Vasilopoulou F, Callado LF, García-Sevilla JA, García-Fuster J, Sureda FX, Pérez B. Novel Imidazoline I2 Receptor Ligands for Alzheimer’s Disease The Faseb Journal. 32. DOI: 10.1096/Fasebj.2018.32.1_Supplement.552.1 |
0.418 |
|
| 2017 |
Odagaki Y, Kinoshita M, Ota T, Javier Meana J, Callado LF, García-Sevilla JA. Functional activation of Gαq coupled to 5-HT2A receptor and M1 muscarinic acetylcholine receptor in postmortem human cortical membranes. Journal of Neural Transmission (Vienna, Austria : 1996). PMID 28687907 DOI: 10.1007/S00702-017-1749-0 |
0.407 |
|
| 2017 |
Keller B, La Harpe R, García-Sevilla JA. Upregulation of IRAS/nischarin (I1-imidazoline receptor), a regulatory protein of μ-opioid receptor trafficking, in postmortem prefrontal cortex of long-term opiate and mixed opiate/cocaine abusers. Neurochemistry International. PMID 28461172 DOI: 10.1016/J.Neuint.2017.04.017 |
0.386 |
|
| 2017 |
Keller B, García-Sevilla JA. Effects of I2-imidazoline receptor (IR) alkylating BU99006 in the mouse brain: Upregulation of nischarin/I1-IR and μ-opioid receptor proteins and modulation of associated signalling pathways. Neurochemistry International. PMID 28342965 DOI: 10.1016/J.Neuint.2017.03.012 |
0.466 |
|
| 2017 |
Salort G, Álvaro-Bartolomé M, García-Sevilla JA. Regulation of cannabinoid CB2 receptor constitutive activity in vivo: repeated treatments with inverse agonists reverse the acute activation of JNK and associated apoptotic signaling in mouse brain. Psychopharmacology. 234: 925-941. PMID 28127623 DOI: 10.1007/S00213-017-4537-5 |
0.434 |
|
| 2017 |
Álvaro-Bartolomé M, Salort G, García-Sevilla JA. Disruption of brain MEK-ERK sequential phosphorylation and activation during midazolam-induced hypnosis in mice: Roles of GABAA receptor, MEK1 inactivation, and phosphatase MKP-3 Progress in Neuro-Psychopharmacology & Biological Psychiatry. 75: 84-93. PMID 28111292 DOI: 10.1016/J.Pnpbp.2017.01.008 |
0.436 |
|
| 2017 |
Salort G, Hernández-Hernández E, García-Fuster MJ, García-Sevilla JA. Regulation of cannabinoid CB1 and CB2 receptors and neuroprotective rapamycin (mTOR protein kinase) in major depression postmortem brains European Neuropsychopharmacology. 27. DOI: 10.1016/S0924-977X(17)31417-7 |
0.403 |
|
| 2017 |
Odagaki Y, Kinoshita M, Ota T, Meana JJ, Callodo LF, Garcia-Sevilla JA. Functional activation of Gi/o proteins coupled to multiple neurotransmitter receptors in postmortem human prefrontal cortical membranes European Neuropsychopharmacology. 27. DOI: 10.1016/S0924-977X(17)31221-X |
0.333 |
|
| 2016 |
Abás S, Erdozain AM, Keller B, Rodríguez-Arévalo S, Callado LF, García-Sevilla JA, Escolano C. Neuroprotective effects of a structurally new family of high affinity imidazoline I2 receptor ligands. Acs Chemical Neuroscience. PMID 28029766 DOI: 10.1021/Acschemneuro.6B00426 |
0.425 |
|
| 2016 |
Keller B, García-Sevilla JA. Dysregulation of IRAS/nischarin and other potential I1-imidazoline receptors in major depression postmortem brain: Downregulation of basal contents by antidepressant drug treatments. Journal of Affective Disorders. PMID 27836117 DOI: 10.1016/J.Jad.2016.10.007 |
0.405 |
|
| 2016 |
Keller B, García-Sevilla JA. Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice. Journal of Psychopharmacology (Oxford, England). PMID 27302941 DOI: 10.1177/0269881116652579 |
0.427 |
|
| 2016 |
García-Fuster MJ, García-Sevilla JA. Effects of anti-depressant treatments on FADD and p-FADD protein in rat brain cortex: enhanced anti-apoptotic p-FADD/FADD ratio after chronic desipramine and fluoxetine administration. Psychopharmacology. 233: 2955-2971. PMID 27259485 DOI: 10.1007/S00213-016-4342-6 |
0.442 |
|
| 2016 |
Odagaki Y, Kinoshita M, Ota T, Meana JJ, Callado LF, Garcia-Sevilla JA. Receptor-mediated activation of Galpha(q) and Galpha(i-3) assessed by [35S]GTPgammaS binding/immunoprecipitation assay in postmortem human brain membranes European Neuropsychopharmacology. 26. DOI: 10.1016/S0924-977X(16)31093-8 |
0.397 |
|
| 2015 |
Álvaro-Bartolomé M, García-Sevilla JA. The neuroplastic index p-FADD/FADD and phosphoprotein PEA-15, interacting at GABAA receptor, are upregulated in brain cortex during midazolam-induced hypnosis in mice. European Neuropsychopharmacology. 25: 2131-2144. PMID 26282360 DOI: 10.1016/J.Euroneuro.2015.07.019 |
0.44 |
|
| 2015 |
Odagaki Y, Kinoshita M, Ota T, Javier Meana J, Callado LF, García-Sevilla JA. Adenosine A1 receptors are selectively coupled to Gαi-3 in postmortem human brain cortex: Guanosine-5'-O-(3-[(35)S]thio)triphosphate ([(35)S]GTPγS) binding/immunoprecipitation study. European Journal of Pharmacology. 764: 592-8. PMID 26213104 DOI: 10.1016/J.Ejphar.2015.07.049 |
0.401 |
|
| 2015 |
Keller B, García-Sevilla JA. Regulation of hippocampal Fas receptor and death-inducing signaling complex after kainic acid treatment in mice Progress in Neuro-Psychopharmacology & Biological Psychiatry. 63: 54-62. PMID 26044520 DOI: 10.1016/J.Pnpbp.2015.04.009 |
0.379 |
|
| 2015 |
Keller B, García-Sevilla JA. Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs Journal of Psychopharmacology. 29: 996-1012. PMID 26038110 DOI: 10.1177/0269881115586936 |
0.363 |
|
| 2015 |
Rivero G, Gabilondo AM, García-Sevilla JA, La Harpe R, Morentín B, Meana JJ. Up-regulated 14-3-3β and 14-3-3ζ proteins in prefrontal cortex of subjects with schizophrenia: effect of psychotropic treatment. Schizophrenia Research. 161: 446-51. PMID 25549848 DOI: 10.1016/J.Schres.2014.12.014 |
0.305 |
|
| 2015 |
García-Fuster MJ, García-Sevilla JA. Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex. Neuropharmacology. 89: 204-14. PMID 25286119 DOI: 10.1016/J.Neuropharm.2014.09.018 |
0.469 |
|
| 2014 |
García-Fuster MJ, Díez-Alarcia R, Ferrer-Alcón M, La Harpe R, Meana JJ, García-Sevilla JA. FADD adaptor and PEA-15/ERK1/2 partners in major depression and schizophrenia postmortem brains: basal contents and effects of psychotropic treatments. Neuroscience. 277: 541-51. PMID 25075716 DOI: 10.1016/J.Neuroscience.2014.07.027 |
0.401 |
|
| 2014 |
Rivero G, Gabilondo AM, García-Sevilla JA, La Harpe R, Callado LF, Meana JJ. Increased α2- and β1-adrenoceptor densities in postmortem brain of subjects with depression: differential effect of antidepressant treatment. Journal of Affective Disorders. 167: 343-50. PMID 25020269 DOI: 10.1016/J.Jad.2014.06.016 |
0.312 |
|
| 2014 |
Odagaki Y, Kinoshita M, Toyoshima R, Meana JJ, Callado LF, García-Sevilla JA. P.1.g.050 Receptor-mediated [35S]GTPgammaS binding in postmortem human brain membranes: optimisation of assay conditions for future studies European Neuropsychopharmacology. 24. DOI: 10.1016/S0924-977X(14)70361-X |
0.427 |
|
| 2014 |
Salort G, Álvaro-Bartolome M, Garcia-Sevilla JA. P.1.g.040 Effects of CB2 receptor inverse agonists on JNK activation and pro-apoptotic Bax in mouse brain European Neuropsychopharmacology. 24. DOI: 10.1016/S0924-977X(14)70351-7 |
0.326 |
|
| 2013 |
Álvaro-Bartolomé M, Salort G, García-Sevilla JA. P.1.g.012 The CB2 ligand AM630 (6-iodopravadoline) increases the content and activity of pro-apoptotic markers in mouse brain European Neuropsychopharmacology. 23. DOI: 10.1016/S0924-977X(13)70299-2 |
0.383 |
|
| 2011 |
Ramos-Miguel A, Meana JJ, García-Sevilla JA. P.3.d.003 The cdk5 cofactor p35 is reduced in schizophrenia postmortem brains: downregulation of cdk5/p35/p25 after antipsychotic medication European Neuropsychopharmacology. 21. DOI: 10.1016/S0924-977X(11)70825-2 |
0.328 |
|
| 2010 |
Ramos-Miguel A, Miralles A, García-Sevilla JA. P.6.d.014 The severity of morphine abstinence correlates with brain FADD phosphorylation: interaction with α2-adrenoceptors European Neuropsychopharmacology. 20. DOI: 10.1016/S0924-977X(10)70908-1 |
0.363 |
|
| 2009 |
Alvaro-Bartolome M, Harpe RL, Meana JJ, Garcia-Sevilla JA. P6.d.003 Opposite regulation of FADD and nuclear poly (ADP-ribose) polymerase (PARP) in brains of cocaine addicts European Neuropsychopharmacology. 19. DOI: 10.1016/S0924-977X(09)71062-4 |
0.325 |
|
| 2008 |
Gracia E, Cortés A, Meana JJ, García-Sevilla J, Herhsfield MS, Canela EI, Mallol J, Lluís C, Franco R, Casadó V. Human adenosine deaminase as an allosteric modulator of human A1 adenosine receptor: abolishment of negative cooperativity for [3H](R)‐pia binding to the caudate nucleus Journal of Neurochemistry. 107: 161-170. PMID 18680557 DOI: 10.1111/J.1471-4159.2008.05602.X |
0.379 |
|
| 2008 |
Ramos-Miguel A, García-Fuster MJ, Callado LF, Harpe RL, Meana JJ, García-Sevilla JA. P.6.d.007 Regulation of phosphorylated forms of the proteins FADD, MAPKs, and PEA-15 in the prefrontal cortex of human opioid abusers European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70824-1 |
0.338 |
|
| 2008 |
Urigüen L, García-Fuster MJ, Callado LF, Morentin B, Harpe RL, Casadó V, Lluis C, Franco R, García-Sevilla JA, Meana JJ. P.3.f.005 A2A-adenosine, D2-dopamine and CB1-cannabinoid receptors in postmortem prefrontal cortex of schizophrenics European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70710-7 |
0.337 |
|
| 2008 |
Garau C, Miralles A, García-Sevilla JA. P.1.c.020 Chronic treatment with imidazoline I2-drugs down-regulates key proteins of the canonical apoptotic pathways in rat brain European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70284-0 |
0.367 |
|
| 2008 |
Álvaro-Bartolomé M, Esteban S, Valverde O, García-Sevilla JA. P.1.c.019 Regulation of pro-apoptotic Fas/FADD protein complex in brain regions of CB1-receptor deficient mice European Neuropsychopharmacology. 18. DOI: 10.1016/S0924-977X(08)70283-9 |
0.405 |
|
| 2007 |
García-Sevilla JA, García-Fuster MJ, Davidson A, Rivero G, LaHarpe R, Meana JJ. P.6.d.004 Regulation of the apoptotic machinery in the prefrontal cortex of human opioid abusers European Neuropsychopharmacology. 17. DOI: 10.1016/S0924-977X(07)70859-3 |
0.325 |
|
| 2007 |
Ramos-Miguel A, Miralles A, Garcia-Sevilla JA. P.1.c.017 Morphine-induced locomotor sensitization increases FADD phosphorylation in rat brain European Neuropsychopharmacology. 17. DOI: 10.1016/S0924-977X(07)70341-3 |
0.363 |
|
| 2006 |
Diez-Alarcia R, Valdizan EM, Gonzalez-Maeso J, Garcia-Sevilla JA, Pazos A, Meana JJ. P.2.b.004 Functional activity of α2-adrenoceptors in postmortem frontal cortex of depressed suicide victims European Neuropsychopharmacology. 16. DOI: 10.1016/S0924-977X(06)70318-2 |
0.314 |
|
| 1999 |
Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, Gasull T, Assumpció Boronat M, Trullas R, Villarroel A, Lerma J, García-Sevilla JA. Protection by imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor. British Journal of Pharmacology. 127: 1317-26. PMID 10455281 DOI: 10.1038/Sj.Bjp.0702679 |
0.321 |
|
| 1997 |
Ventayol P, Busquets X, Garcia-Sevilla JA. Modulation of immunoreactive protein kinase C-alpha and beta isoforms and G proteins by acute and chronic treatments with morphine and other opiate drugs in rat brain. Naunyn-Schmiedeberg's Archives of Pharmacology. 355: 491-500. PMID 9109366 DOI: 10.1007/Pl00004974 |
0.355 |
|
| 1997 |
García-Sevilla JA, Escribá PV, Harpe RL, Harding T, Walzer C, Guimón J. Immunoreactive α2a-adrenoceptors and associated regulatory proteins in brains of suicides Biological Psychiatry. 42: 285. DOI: 10.1016/S0006-3223(97)88093-6 |
0.325 |
|
| 1994 |
Escriba PV, Sastre M, Garcia-Sevilla JA. Increased density of guanine nucleotide-binding proteins in the postmortem brains of heroin addicts. Archives of General Psychiatry. 51: 494-501. PMID 8192552 DOI: 10.1001/Archpsyc.1994.03950060058006 |
0.427 |
|
| 1992 |
Garcia-Sevilla JA, Gabilondo AM, Sastre M, Meana JJ, Barturen F. α-2-Adrenoceptor and μ-opioid receptor densities in the postmortem brain of heroin addicts European Neuropsychopharmacology. 2: 283-284. DOI: 10.1016/0924-977X(92)90114-N |
0.398 |
|
| 1987 |
Garcia-Sevilla JA, Udina C, Fuster MJ, Alvarez E, Casas M. Enhanced binding of [3H] (-) adrenaline to platelets of depressed patients with melancholia: effect of long-term clomipramine treatment. Acta Psychiatrica Scandinavica. 75: 150-7. PMID 3031932 DOI: 10.1111/J.1600-0447.1987.Tb02767.X |
0.329 |
|
| 1986 |
Garcia-Sevilla JA, Fuster MJ. Labelling of human platelet alpha 2-adrenoceptors with the full agonist [3H](-)adrenaline. European Journal of Pharmacology. 124: 31-41. PMID 3013661 DOI: 10.1016/0014-2999(86)90121-4 |
0.322 |
|
| 1986 |
Garcia-Sevilla JA, Ugedo L, Ulibarri I, Gutierrez M. Heroin increases the density and sensitivity of platelet alpha 2-adrenoceptors in human addicts. Psychopharmacology. 88: 489-92. PMID 3010362 DOI: 10.1007/Bf00178512 |
0.327 |
|
| 1985 |
Garcia-Sevilla JA, Ugedo L, Ulibarri I, Gutierrez M. Platelet alpha 2-adrenoceptors in heroin addicts during withdrawal and after treatment with clonidine. European Journal of Pharmacology. 114: 365-74. PMID 2998814 DOI: 10.1016/0014-2999(85)90382-6 |
0.331 |
|
| 1983 |
Smith CB, Hollingsworth PJ, Garcia-Sevilla JA, Zis AP. Platelet alpha 2 adrenoreceptors are decreased in number after antidepressant therapy. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 7: 241-7. PMID 6310693 DOI: 10.1016/0278-5846(83)90114-8 |
0.301 |
|
| 1979 |
Garcia-Sevilla JA, Magnusson T, Carlsson A. Opposite effects of naloxone on substance P-induced changes in brain DOPA synthesis and in locomotor activity in rats. Journal of Neural Transmission. 45: 185-93. PMID 479872 DOI: 10.1007/Bf01244407 |
0.383 |
|
| 1978 |
Garcia-Sevilla JA, Magnusson T, Carlsson A. Effect of intracerebroventricularly administered somatostatin on brain monoamine turnover. Brain Research. 155: 159-64. PMID 308386 DOI: 10.1016/0006-8993(78)90318-9 |
0.34 |
|
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