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Steven G. Younkin, MD, University of Pennsylvania, PhD, University of Pennsylvania - Publications

Affiliations: 
Research Mayo Cllinic Jacksonville, Jacksonville, FL, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=35
Website:
http://mayoresearch.mayo.edu/mayo/research/staff/younkin_sg.cfm

307 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wang X, Allen M, İş Ö, Reddy JS, Tutor-New FQ, Castanedes Casey M, Carrasquillo MM, Oatman SR, Min Y, Asmann YW, Funk C, Nguyen T, Ho CC, Malphrus KG, Seyfried NT, ... ... Younkin SG, et al. Alzheimer's disease and progressive supranuclear palsy share similar transcriptomic changes in distinct brain regions. The Journal of Clinical Investigation. PMID 34813500 DOI: 10.1172/JCI149904  0.761
2021 Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, et al. Correction to: Apolipoprotein E regulates lipid metabolism and α‑synuclein pathology in human iPSC‑derived cerebral organoids. Acta Neuropathologica. PMID 34724591 DOI: 10.1007/s00401-021-02380-6  0.443
2021 Zhao J, Lu W, Ren Y, Fu Y, Martens YA, Shue F, Davis MD, Wang X, Chen K, Li F, Liu CC, Graff-Radford NR, Wszolek ZK, Younkin SG, Brafman DA, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathologica. PMID 34453582 DOI: 10.1007/s00401-021-02361-9  0.553
2021 Damotte V, van der Lee SJ, Chouraki V, Grenier-Boley B, Simino J, Adams H, Tosto G, White C, Terzikhan N, Cruchaga C, Knol MJ, Li S, Schraen S, Grove ML, Satizabal C, ... ... Younkin S, et al. Plasma amyloid β levels are driven by genetic variants near APOE, BACE1, APP, PSEN2: A genome-wide association study in over 12,000 non-demented participants. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34002480 DOI: 10.1002/alz.12333  0.322
2021 Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, ... Younkin SG, et al. Author Correction: APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature Communications. 12: 2707. PMID 33953196 DOI: 10.1038/s41467-021-23081-4  0.555
2021 Wickland DP, Ren Y, Sinnwell JP, Reddy JS, Pottier C, Sarangi V, Carrasquillo MM, Ross OA, Younkin SG, Ertekin-Taner N, Rademakers R, Hudson ME, Mainzer LS, Biernacka JM, Asmann YW. Impact of variant-level batch effects on identification of genetic risk factors in large sequencing studies. Plos One. 16: e0249305. PMID 33861770 DOI: 10.1371/journal.pone.0249305  0.526
2021 Li HD, Funk CC, McFarland K, Dammer EB, Allen M, Carrasquillo MM, Levties Y, Chakrabarty P, Burgess JD, Wang X, Dickson D, Seyfried NT, Duong DM, Lah JJ, Younkin SG, et al. Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33480174 DOI: 10.1002/alz.12254  0.771
2020 Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, ... Younkin SG, et al. APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids. Nature Communications. 11: 5540. PMID 33139712 DOI: 10.1038/s41467-020-19264-0  0.591
2020 Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, et al. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 11: 667. PMID 32015339 DOI: 10.1038/S41467-019-14279-8  0.467
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Younkin SG, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7  0.688
2019 Sakae N, Heckman MG, Vargas ER, Carrasquillo MM, Murray ME, Kasanuki K, Ertekin-Taner N, Younkin SG, Dickson DW. Evaluation of Associations of Alzheimer's Disease Risk Variants that Are Highly Expressed in Microglia with Neuropathological Outcome Measures. Journal of Alzheimer's Disease : Jad. PMID 31256143 DOI: 10.3233/Jad-190451  0.679
2019 Ebbert MTW, Jensen TD, Jansen-West K, Sens JP, Reddy JS, Ridge PG, Kauwe JSK, Belzil V, Pregent L, Carrasquillo MM, Keene D, Larson E, Crane P, Asmann YW, Ertekin-Taner N, ... Younkin SG, et al. Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight. Genome Biology. 20: 97. PMID 31104630 DOI: 10.1186/S13059-019-1707-2  0.564
2019 Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Younkin SG, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2  0.715
2019 Reddy JS, Allen M, Wang X, Biernacka JM, Gregory JD, Carrasquillo MM, Ertekin-Taner N, Younkin SG. O2-10-01: STOP-GAIN AND NON-SYNONYMOUS VARIANTS IN NOVEL GENES OF AN IMMUNE CO-REGULATORY NETWORK SHOW STRONG ASSOCIATION WITH ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P563-P564. DOI: 10.1016/J.Jalz.2019.06.4505  0.699
2018 Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, ... ... Younkin SG, et al. TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer's disease. The Journal of Experimental Medicine. PMID 30158114 DOI: 10.1084/Jem.20180484  0.764
2018 Allen M, Wang X, Serie DJ, Strickland SL, Burgess JD, Koga S, Younkin CS, Nguyen TT, Malphrus KG, Lincoln SJ, Alamprese M, Zhu K, Chang R, Carrasquillo MM, Kouri N, ... ... Younkin SG, et al. Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy. Acta Neuropathologica. PMID 30136084 DOI: 10.1007/S00401-018-1900-5  0.752
2018 Ogaki K, Heckman MG, Koga S, Martens YA, Labbé C, Lorenzo-Betancor O, Walton RL, Soto AI, Vargas ER, Fujioka S, Uitti RJ, van Gerpen JA, Cheshire WP, Younkin SG, Wszolek ZK, et al. Association study between multiple system atrophy and TREM2 p.R47H. Neurology. Genetics. 4: e257. PMID 30109269 DOI: 10.1212/Nxg.0000000000000257  0.434
2018 Chung J, Zhang X, Allen M, Wang X, Ma Y, Beecham G, Montine TJ, Younkin SG, Dickson DW, Golde TE, Price ND, Ertekin-Taner N, Lunetta KL, Mez J, et al. Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease. Alzheimer's Research & Therapy. 10: 22. PMID 29458411 DOI: 10.1186/S13195-018-0349-Z  0.774
2018 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Younkin SG, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7  0.765
2017 Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Younkin SG, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1  0.768
2017 Allen M, Wang X, Burgess JD, Watzlawik J, Serie DJ, Younkin CS, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Ho C, Chakrabarty P, Strickland S, Murray ME, Swarup V, ... ... Younkin SG, et al. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29107053 DOI: 10.1016/J.Jalz.2017.09.012  0.825
2017 Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Younkin SG, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916  0.78
2017 Simino J, Wang Z, Bressler J, Chouraki V, Yang Q, Younkin SG, Seshadri S, Fornage M, Boerwinkle E, Mosley TH. Whole exome sequence-based association analyses of plasma amyloid-β in African and European Americans; the Atherosclerosis Risk in Communities-Neurocognitive Study. Plos One. 12: e0180046. PMID 28704393 DOI: 10.1371/Journal.Pone.0180046  0.364
2017 N'Songo A, Carrasquillo MM, Wang X, Burgess JD, Nguyen T, Asmann YW, Serie DJ, Younkin SG, Allen M, Pedraza O, Duara R, Greig Custo MT, Graff-Radford NR, Ertekin-Taner N. African American exome sequencing identifies potential risk variants at Alzheimer disease loci. Neurology. Genetics. 3: e141. PMID 28480329 DOI: 10.1212/Nxg.0000000000000141  0.736
2017 Zhao J, Davis MD, Atagi Y, Shinohara M, Graff-Radford NR, Younkin SG, Wszolek ZK, Kanekiyo T, Bu G. APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes. Human Molecular Genetics. PMID 28444230 DOI: 10.1093/Hmg/Ddx155  0.364
2017 Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, ... ... Younkin SG, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28183528 DOI: 10.1016/J.Jalz.2016.12.012  0.652
2017 N'Songo A, Carrasquillo MM, Wang X, Nguyen T, Asmann Y, Younkin SG, Allen M, Duara R, Custo MT, Graff-Radford N, Ertekin-Taner N. Comprehensive Screening for Disease Risk Variants in Early-Onset Alzheimer's Disease Genes in African Americans Identifies Novel PSEN Variants. Journal of Alzheimer's Disease : Jad. PMID 28106563 DOI: 10.3233/Jad-161185  0.726
2017 Allen M, Wang X, Reddy JS, Carrasquillo MM, Younkin CS, Funk C, Burgess JD, Nguyen T, Lincoln SJ, Malphrus KG, Asmann YW, Younkin SG, Price ND, Golde TE, Dickson DW, et al. USING TISSUE-BASED TRANSCRIPTOMICS TO PROFILE CELL TYPE VARIABILITY IN THE BRAIN Alzheimer's & Dementia. 13: P588-P589. DOI: 10.1016/J.Jalz.2017.07.218  0.619
2017 Allen M, Wang X, Younkin CS, Serie D, Burgess JD, Nguyen T, Lincoln SJ, Malphrus KG, Carrasquillo MM, Kouri N, Murray ME, Schellenberg GD, Younkin SG, Crook JE, Asmann YW, et al. [P4-074]: INTEGRATIVE SYSTEMS BIOLOGY APPROACH TO IDENTIFY NOVEL RISK FACTORS FOR PSP Alzheimer's & Dementia. 13: P1286-P1286. DOI: 10.1016/J.Jalz.2017.06.1939  0.63
2017 Carrasquillo MM, Ho CC, Nsongo A, Wang X, Burgess JD, Nguyen T, Ma L, Bisceglio GD, Lincoln SJ, Malphrus KG, Asmann YW, Younkin SG, Duara R, Greig Custo MT, Graff-Radford NR, et al. [P3-096]: NOVEL CANDIDATE AD-RISK LOCI IDENTIFIED THROUGH WHOLE EXOME SEQUENCING IN AFRICAN-AMERICANS Alzheimer's & Dementia. 13: P971-P971. DOI: 10.1016/J.Jalz.2017.06.1306  0.597
2016 Carrasquillo MM, Allen M, Burgess JD, Wang X, Strickland SL, Aryal S, Siuda J, Kachadoorian ML, Medway C, Younkin CS, Nair A, Wang C, Chanana P, Serie D, Nguyen T, ... ... Younkin SG, et al. A candidate regulatory variant at the TREM gene cluster associates with decreased Alzheimer's disease risk and increased TREML1 and TREM2 brain gene expression. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27939925 DOI: 10.1016/J.Jalz.2016.10.005  0.772
2016 Ma L, Allen M, Sakae N, Ertekin-Taner N, Graff-Radford NR, Dickson DW, Younkin SG, Sevlever D. Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains. Molecular Neurodegeneration. 11: 72. PMID 27887626 DOI: 10.1186/S13024-016-0137-9  0.731
2016 Allen M, Carrasquillo MM, Funk C, Heavner BD, Zou F, Younkin CS, Burgess JD, Chai HS, Crook J, Eddy JA, Li H, Logsdon B, Peters MA, Dang KK, Wang X, ... ... Younkin SG, et al. Human whole genome genotype and transcriptome data for Alzheimer's and other neurodegenerative diseases. Scientific Data. 3: 160089. PMID 27727239 DOI: 10.1038/Sdata.2016.89  0.79
2016 Pottier C, Ravenscroft TA, Brown PH, Finch NA, Baker M, Parsons M, Asmann YW, Ren Y, Christopher E, Levitch D, van Blitterswijk M, Cruchaga C, Campion D, Nicolas G, Richard AC, ... ... Younkin S, et al. TYROBP genetic variants in early-onset Alzheimer's disease. Neurobiology of Aging. PMID 27658901 DOI: 10.1016/J.Neurobiolaging.2016.07.028  0.665
2016 Labbé C, Heckman MG, Lorenzo-Betancor O, Murray ME, Ogaki K, Soto-Ortolaza AI, Walton RL, Fujioka S, Koga S, Uitti RJ, van Gerpen JA, Petersen RC, Graff-Radford NR, Younkin SG, Boeve BF, et al. MAPT haplotype diversity in multiple system atrophy. Parkinsonism & Related Disorders. PMID 27374978 DOI: 10.1016/J.Parkreldis.2016.06.010  0.397
2016 Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hofree M, Huang R, ... ... Younkin SG, et al. Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 42. PMID 27216421 DOI: 10.1186/S13024-016-0105-4  0.302
2016 Allen M, Burgess JD, Ballard T, Serie D, Wang X, Younkin CS, Sun Z, Kouri N, Baheti S, Wang C, Carrasquillo MM, Nguyen T, Lincoln S, Malphrus K, Murray M, ... ... Younkin SG, et al. Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci. Acta Neuropathologica. PMID 27115769 DOI: 10.1007/S00401-016-1576-7  0.738
2016 Jaeger PA, Lucin KM, Britschgi M, Vardarajan B, Huang RP, Kirby ED, Abbey R, Boeve BF, Boxer AL, Farrer LA, Finch N, Graff-Radford NR, Head E, Hoffree M, Huang R, ... ... Younkin SG, et al. Network-driven plasma proteomics expose molecular changes in the Alzheimer's brain. Molecular Neurodegeneration. 11: 31. PMID 27112350 DOI: 10.1186/S13024-016-0095-2  0.379
2016 Sakae N, Liu CC, Shinohara M, Frisch-Daiello J, Ma L, Yamazaki Y, Tachibana M, Younkin L, Kurti A, Carrasquillo MM, Zou F, Sevlever D, Bisceglio G, Gan M, Fol R, ... ... Younkin SG, et al. ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3848-59. PMID 27030769 DOI: 10.1523/Jneurosci.3757-15.2016  0.447
2016 Allen M, Wang X, Burgess JD, Nguyen T, Malphrus KG, Nho K, Serie D, Strickland SL, Lincoln S, Carrasquillo MM, Crook JE, Schellenberg GD, Knopman DS, Saykin AJ, Lowe VJ, ... ... Younkin SG, et al. Blood Gene Expression Changes Implicated In Alzheimer’S Disease Alzheimers & Dementia. 12: 448. DOI: 10.1016/J.Jalz.2016.06.865  0.663
2016 Golde TE, Ertekin-Taner N, Chakrabarty P, Allen M, Carrasquillo MM, Dickson DW, Younkin SG, Levites Y, Price ND, Funk C, Heavner BD, Logsdon B, Mangravite LM, Li H, Burgess JD, et al. F2-01-04: From Systems Level Transcriptomics to new Immune Targets for Alzheimer’s Disease Alzheimer's & Dementia. 12: P215-P216. DOI: 10.1016/J.Jalz.2016.06.383  0.686
2016 Allen M, Wang X, Younkin CS, Serie D, Sun Z, Burgess JD, Baheti S, Kouri N, Nguyen T, Lincoln S, Malphrus KG, Carrasquillo MM, Zou F, Chai H, Murray ME, ... ... Younkin SG, et al. P4-048: Convergent Analysis of Endophenotypes in Progressive Supranuclear Palsy Alzheimer's & Dementia. 12: P1032-P1033. DOI: 10.1016/J.Jalz.2016.06.2137  0.644
2016 Clement NS, Medway C, Ertekin-Taner N, Carrasquillo MM, Younkin SG, Guetta-Baranes T, Burgess JD, Allen M, Tam T, Dickson DW, Petersen RC, Graff-Radford NR, Chappell S, Morgan K. P3-092: Mapping Regulatory Variants in the Alzheimer's Disease Candidate Gene ABCA7 Alzheimer's & Dementia. 12: P855-P855. DOI: 10.1016/J.Jalz.2016.06.1751  0.721
2016 Sevlever D, Younkin M, Ma L, Nobutaka S, Bisceglio G, Dickson DW, Ertekin-Taner N, Younkin SG. P2-125: Analysis of Wild Type and R47H Mutant TREM2 Expression in Alzheimer's Disease Brains Alzheimer's & Dementia. 12: P659-P659. DOI: 10.1016/J.Jalz.2016.06.1495  0.623
2016 Kauwe K, Arano I, Bras JT, Cannon-Albright L, Cruchaga C, Goate AM, Murcia JDG, Guerreiro R, Hardy J, Hsu S, Karch C, Munger RG, Norton MC, Ridge PG, Sassi C, ... ... Younkin SG, et al. Linkage And Whole Genome Sequence Analysis Of Alzheimer'S Disease Resilience And Risk Alzheimers & Dementia. 12: 675. DOI: 10.1016/J.Jalz.2016.06.1325  0.417
2016 Nsongo A, Carrasquillo MM, Wang X, Burgess JD, Nguyen T, Asmann YW, Younkin SG, Graff-Radford NR, Ertekin-Taner N. P2-079: Assessment of The Known and Candidate Alzheimer's Disease Genes in African-Americans Alzheimer's & Dementia. 12: P639-P639. DOI: 10.1016/J.Jalz.2016.06.1284  0.631
2015 Allen M, Kachadoorian M, Carrasquillo MM, Karhade A, Manly L, Burgess JD, Wang C, Serie D, Wang X, Siuda J, Zou F, Chai HS, Younkin C, Crook J, Medway C, ... ... Younkin SG, et al. Late-onset Alzheimer disease risk variants mark brain regulatory loci. Neurology. Genetics. 1: e15. PMID 27066552 DOI: 10.1212/Nxg.0000000000000012  0.762
2015 Carrasquillo MM, Barber I, Lincoln SJ, Murray ME, Camsari GB, Khan QU, Nguyen T, Ma L, Bisceglio GD, Crook JE, Younkin SG, Dickson DW, Boeve BF, Graff-Radford NR, Morgan K, et al. Evaluating pathogenic dementia variants in posterior cortical atrophy. Neurobiology of Aging. PMID 26507310 DOI: 10.1016/J.Neurobiolaging.2015.09.023  0.613
2015 Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, Zheng H, Li X, Rademakers R, Kang SS, Xu H, Younkin S, Das P, Fryer JD, Bu G. Apolipoprotein E is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of Biological Chemistry. PMID 26374899 DOI: 10.1074/Jbc.M115.679043  0.407
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Younkin SG, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/Ncomms8247  0.702
2015 Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, ... ... Younkin SG, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. PMID 25778476 DOI: 10.1038/Mp.2015.23  0.448
2015 Malik M, Chiles J, Xi HS, Medway C, Simpson J, Potluri S, Howard D, Liang Y, Paumi CM, Mukherjee S, Crane P, Younkin S, Fardo DW, Estus S. Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia. Human Molecular Genetics. 24: 3557-70. PMID 25762156 DOI: 10.1093/Hmg/Ddv092  0.326
2015 Braae A, Medway C, Carrasquillo M, Younkin S, Kehoe PG, Morgan K. Blood type gene locus has no influence on ACE association with Alzheimer's disease. Neurobiology of Aging. 36: 1767.e1-2. PMID 25681990 DOI: 10.1016/J.Neurobiolaging.2015.01.013  0.433
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Younkin SG, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157  0.659
2015 Chouraki V, Beiser A, Younkin L, Preis SR, Weinstein G, Hansson O, Skoog I, Lambert JC, Au R, Launer L, Wolf PA, Younkin S, Seshadri S. Plasma amyloid-β and risk of Alzheimer's disease in the Framingham Heart Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 249-57.e1. PMID 25217292 DOI: 10.1016/J.Jalz.2014.07.001  0.455
2015 Carrasquillo MM, Crook JE, Pedraza O, Thomas CS, Pankratz VS, Allen M, Nguyen T, Malphrus KG, Ma L, Bisceglio GD, Roberts RO, Lucas JA, Smith GE, Ivnik RJ, Machulda MM, ... ... Younkin SG, et al. Late-onset Alzheimer's risk variants in memory decline, incident mild cognitive impairment, and Alzheimer's disease. Neurobiology of Aging. 36: 60-7. PMID 25189118 DOI: 10.1016/J.Neurobiolaging.2014.07.042  0.681
2015 Braae A, Medway C, Carrasquillo M, Younkin S, Kehoe PG, Morgan K, Craig D, Johnston J, McGuinness B, Todd S, Heun R, Kölsch H, Vardy ERLC, Hooper NM, Mann DM, et al. Blood type gene locus has no influence on ACE association with Alzheimer's disease Neurobiology of Aging. 36: 1767.e1-1767.e2. DOI: 10.1016/j.neurobiolaging.2015.01.013  0.317
2015 Allen M, Wang X, Younkin CS, Burgess JD, Ballard T, Serie D, Wang C, Sun Z, Baheti S, Carrasquillo MM, Nguyen T, Malphrus KG, Lincoln S, Zou F, Chai H, ... ... Younkin SG, et al. P2-025: Genetic and epigenetic influences on brain gene expression in psp Alzheimer's & Dementia. 11: P490-P491. DOI: 10.1016/J.Jalz.2015.06.561  0.547
2015 Burgess JD, Allen M, Kachadoorian M, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Schellenberg GD, Knopman DS, Lowe VJ, Jack CR, Younkin SG, Dickson DW, Petersen RC, Taner N. Exploring alternative splicing and gene expression of load candidate genes in blood Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.06.551  0.515
2015 Nsongo A, Carrasquillo MM, Barber I, Nguyen T, Ma L, Bisceglio G, Younkin SG, Graff-Radford N, Morgan K, Taner N. P1-060: Neurox associations with Alzheimer's disease in african americans Alzheimer's & Dementia. 11: P361-P362. DOI: 10.1016/J.Jalz.2015.06.257  0.448
2015 Allen M, Wang X, Serie D, Strickland SL, Burgess JD, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Crook J, Schellenberg GD, Knopman DS, Lowe VJ, Jack CR, Younkin SG, et al. Exploiting blood transcriptome for gene and pathway identification in Alzheimer's disease Alzheimers & Dementia. 11: 357. DOI: 10.1016/J.Jalz.2015.06.245  0.601
2014 Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HS, Younkin C, Crook JE, Pankratz VS, Carrasquillo MM, Krishnan S, Nguyen T, Ma L, Malphrus K, Lincoln S, Bisceglio G, ... ... Younkin SG, et al. Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels. Alzheimer's Research & Therapy. 6: 39. PMID 25324900 DOI: 10.1186/Alzrt268  0.726
2014 Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Younkin SG, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491  0.636
2014 Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/Journal.Pgen.1004606  0.477
2014 Parikh I, Medway C, Younkin S, Fardo DW, Estus S. An intronic PICALM polymorphism, rs588076, is associated with allelic expression of a PICALM isoform. Molecular Neurodegeneration. 9: 32. PMID 25169757 DOI: 10.1186/1750-1326-9-32  0.414
2014 De Jager PL, Srivastava G, Lunnon K, Burgess J, Schalkwyk LC, Yu L, Eaton ML, Keenan BT, Ernst J, McCabe C, Tang A, Raj T, Replogle J, Brodeur W, Gabriel S, ... ... Younkin SG, et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci. Nature Neuroscience. 17: 1156-63. PMID 25129075 DOI: 10.1038/Nn.3786  0.639
2014 Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Younkin SG, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661  0.48
2014 Carrasquillo MM, Khan Qu, Murray ME, Krishnan S, Aakre J, Pankratz VS, Nguyen T, Ma L, Bisceglio G, Petersen RC, Younkin SG, Dickson DW, Boeve BF, Graff-Radford NR, Ertekin-Taner N. Late-onset Alzheimer disease genetic variants in posterior cortical atrophy and posterior AD. Neurology. 82: 1455-62. PMID 24670887 DOI: 10.1212/Wnl.0000000000000335  0.657
2014 Medway CW, Abdul-Hay S, Mims T, Ma L, Bisceglio G, Zou F, Pankratz S, Sando SB, Aasly JO, Barcikowska M, Siuda J, Wszolek ZK, Ross OA, Carrasquillo M, Dickson DW, ... ... Younkin SG, et al. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. Molecular Neurodegeneration. 9: 11. PMID 24607147 DOI: 10.1186/1750-1326-9-11  0.638
2014 Pedraza O, Allen M, Jennette K, Carrasquillo M, Crook J, Serie D, Pankratz VS, Palusak R, Nguyen T, Malphrus K, Ma L, Bisceglio G, Roberts RO, Lucas JA, Ivnik RJ, ... ... Younkin SG, et al. Evaluation of memory endophenotypes for association with CLU, CR1, and PICALM variants in black and white subjects. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 205-13. PMID 23643458 DOI: 10.1016/J.Jalz.2013.01.016  0.662
2014 Medway CW, Abdul-Hay S, Mims T, Zou F, Ma L, Bisceglio G, Pankratz S, Sando S, Aasly J, Barcikowska M, Siuda J, Wszolek Z, Ross O, Carrasquillo MM, Dickson DW, ... ... Younkin S, et al. P1-055: MULTIPLE ABCA7 MISSENSE VARIANTS MINED FROM THE EXOME VARIANT SERVER SHOW INDEPENDENT ASSOCIATION WITH INCREASED OR DECREASED RISK OF LATE-ONSET ALZHEIMER'S DISEASE (LOAD) Alzheimer's & Dementia. 10: P323-P323. DOI: 10.1016/J.Jalz.2014.05.291  0.661
2014 Carrasquillo MM, Allen M, Zou F, Chai HS, Younkin C, Crook J, Pancratz VS, Nair A, Middha S, Maharjan S, Nguyen T, Ma L, Lincoln S, Malphrus K, Bisceglio G, ... ... Younkin S, et al. P3-022: TRANSCRIPTIONAL REGULATION AT THE TREM GENE CLUSTER IN AD BRAINS Alzheimer's & Dementia. 10: P635-P635. DOI: 10.1016/J.Jalz.2014.05.1109  0.677
2014 Kachadoorian M, Allen M, Lincoln S, Karhade A, Manly L, Zou F, Chai HS, Younkin C, Crook J, Pancratz VS, Carrasquillo MM, Nair A, Middha S, Maharjan S, Nguyen T, ... ... Younkin S, et al. O4-04-06: TRANSCRIPTIONAL REGULATION OF GENES AT THE ALZHEIMER'S DISEASE RISK LOCI Alzheimer's & Dementia. 10: P258-P258. DOI: 10.1016/J.Jalz.2014.04.407  0.705
2014 Allen M, Serie D, Sun Z, Baheti S, Walsh M, Zou F, Chai HS, Younkin C, Siuda J, Burgess J, Crook J, Pancratz VS, Carrasquillo MM, Nair A, Middha S, ... ... Younkin S, et al. O3-04-06: GENE EXPRESSION PROFILING AND DNA METHYLATION IN ALZHEIMER'S DISEASE BRAINS Alzheimer's & Dementia. 10: P216-P216. DOI: 10.1016/J.Jalz.2014.04.291  0.692
2014 Ertekin-Taner N, Wang C, Carrasquillo MM, Allen M, Younkin C, Serie D, Wang X, Pancratz VS, Nguyen T, Ma L, Malphrus K, Lincoln S, Petersen RC, Graff-Radford NR, Dickson DW, ... Younkin S, et al. O3-04-01: NEXT-GENERATION RNA SEQUENCING IN ALZHEIMER'S DISEASE AND PROGRESSIVE SUPRANUCLEAR PALSY Alzheimer's & Dementia. 10: P214-P215. DOI: 10.1016/J.Jalz.2014.04.286  0.676
2013 Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Younkin SG, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802  0.471
2013 Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, Lippa C, Josephs KA, Knopman DS, White CL, Caselli R, ... ... Younkin SG, et al. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Molecular Neurodegeneration. 8: 19. PMID 23800361 DOI: 10.1186/1750-1326-8-19  0.66
2013 Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, ... ... Younkin SG, et al. LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD). Plos One. 8: e64164. PMID 23750206 DOI: 10.1371/Journal.Pone.0064164  0.742
2013 Zou F, Belbin O, Carrasquillo MM, Culley OJ, Hunter TA, Ma L, Bisceglio GD, Allen M, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Linking protective GAB2 variants, increased cortical GAB2 expression and decreased Alzheimer's disease pathology. Plos One. 8: e64802. PMID 23724096 DOI: 10.1371/Journal.Pone.0064802  0.559
2013 Park L, Zhou J, Zhou P, Pistick R, El Jamal S, Younkin L, Pierce J, Arreguin A, Anrather J, Younkin SG, Carlson GA, McEwen BS, Iadecola C. Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proceedings of the National Academy of Sciences of the United States of America. 110: 3089-94. PMID 23382216 DOI: 10.1073/Pnas.1300021110  0.372
2013 Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1651-9. PMID 23345237 DOI: 10.1523/Jneurosci.3191-12.2013  0.34
2013 Tan WW, Heckman MG, Vishnu P, Crook JE, Younkin LH, Covil EG, Ferman TJ, Graff-Radford NR, Younkin SG, Smallridge RC, Wehle MJ, Buskirk SJ. Effect of leuprolide on serum amyloid-β peptide levels and memory in patients with prostate cancer with biochemical recurrence. Urology. 81: 150-4. PMID 23273081 DOI: 10.1016/J.Urology.2012.08.066  0.309
2013 Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851  0.527
2013 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Younkin SG, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 45: 712-712. DOI: 10.1038/Ng0613-712A  0.45
2013 Chouraki V, Beiser A, Younkin L, Au R, DeCarli C, Wolf P, Younkin S, Seshadri S. P1-235: Association of plasma beta-amyloid levels and risk of dementia, Alzheimer's disease, brain structure and cognitive functions in the Framingham Heart Study Alzheimer's & Dementia. 9: P238-P239. DOI: 10.1016/J.Jalz.2013.05.459  0.455
2013 Carrasquillo M, Crook J, Pedraza O, Pankratz V, Allen M, Nguyen T, Malphrus K, Ma L, Bisceglio G, Roberts R, Lucas J, Ivnik R, Machulda M, Graff-Radford N, Petersen R, ... Younkin S, et al. P4-004: Association study of late-onset Alzheimer's disease risk variants and memory decline Alzheimer's & Dementia. 9: P706-P706. DOI: 10.1016/J.Jalz.2013.05.1392  0.722
2013 Carrasquillo M, Khan QuA, Murray M, Krishnan S, Nguyen T, Ma L, Bisceglio G, Dickson D, Younkin S, Boeve B, Graff-Radford N, Ertekin-Taner N. Association study of late-onset Alzheimer's disease risk variants and risk for posterior cortical atrophy Alzheimers & Dementia. 9: 553. DOI: 10.1016/J.Jalz.2013.05.1078  0.625
2013 Allen M, Kachadoorian M, Quicksall Z, Zou F, Chai HS, Younkin C, Crook J, Pankratz V, Carrasquillo M, Krishnan S, Nguyen T, Ma L, Malphrus K, Lincoln S, Bisceglio G, ... ... Younkin S, et al. O5-01-05: Haplotypes at the MAPT locus associate with risk for LOAD and brain gene expression Alzheimer's & Dementia. 9: P829-P829. DOI: 10.1016/J.Jalz.2013.04.473  0.677
2012 Rutherford NJ, Carrasquillo MM, Li M, Bisceglio G, Menke J, Josephs KA, Parisi JE, Petersen RC, Graff-Radford NR, Younkin SG, Dickson DW, Rademakers R. TMEM106B risk variant is implicated in the pathologic presentation of Alzheimer disease. Neurology. 79: 717-8. PMID 22855871 DOI: 10.1212/Wnl.0B013E318264E3Ac  0.449
2012 Kamboh MI, Demirci FY, Wang X, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ, Jun G, Baldwin C, Logue MW, Buros J, Farrer L, Pericak-Vance MA, et al. Genome-wide association study of Alzheimer's disease. Translational Psychiatry. 2: e117. PMID 22832961 DOI: 10.1038/Tp.2012.45  0.385
2012 Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Younkin SG, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801  0.732
2012 Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Younkin SG, et al. Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. Plos Genetics. 8: e1002707. PMID 22685416 DOI: 10.1371/Journal.Pgen.1002707  0.751
2012 Allen M, Zou F, Chai HS, Younkin CS, Miles R, Nair AA, Crook JE, Pankratz VS, Carrasquillo MM, Rowley CN, Nguyen T, Ma L, Malphrus KG, Bisceglio G, Ortolaza AI, ... ... Younkin SG, et al. Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications. Molecular Neurodegeneration. 7: 13. PMID 22494505 DOI: 10.1186/1750-1326-7-13  0.738
2012 Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P, Morgan K. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging. 33: 1849.e5-18. PMID 22445811 DOI: 10.1016/J.Neurobiolaging.2012.02.014  0.405
2012 Hamilton G, Killick R, Lambert JC, Amouyel P, Carrasquillo MM, Pankratz VS, Graff-Radford NR, Dickson DW, Petersen RC, Younkin SG, Powell JF, Wade-Martins R. Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus. Neurobiology of Aging. 33: 1848.e1-13. PMID 22405046 DOI: 10.1016/J.Neurobiolaging.2012.02.005  0.446
2012 Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Younkin SG, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/Jad-2011-110824  0.523
2012 Kamboh MI, Barmada MM, Demirci FY, Minster RL, Carrasquillo MM, Pankratz VS, Younkin SG, Saykin AJ, Sweet RA, Feingold E, DeKosky ST, Lopez OL. Genome-wide association analysis of age-at-onset in Alzheimer's disease. Molecular Psychiatry. 17: 1340-6. PMID 22005931 DOI: 10.1038/Mp.2011.135  0.395
2012 Allen M, Cox C, Belbin O, Ma L, Bisceglio GD, Wilcox SL, Howell CC, Hunter TA, Culley O, Walker LP, Carrasquillo MM, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG, et al. Association and heterogeneity at the GAPDH locus in Alzheimer's disease. Neurobiology of Aging. 33: 203.e25-33. PMID 20864222 DOI: 10.1016/J.Neurobiolaging.2010.08.002  0.69
2012 Ertekin-Taner N, Zou F, Chai HS, Younkin C, Crook J, Pankratz V, Allen M, Carrasquillo M, Rowley C, Nair A, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus K, ... ... Younkin S, et al. Identification of human disease-associated variants in a brain expression genome-wide association study (eGWAS) Alzheimers & Dementia. 8: 178. DOI: 10.1016/J.Jalz.2012.05.480  0.695
2012 Ertekin-Taner N, Allen M, Murray M, Crook J, Serie D, Zou F, Chai HS, Younkin C, Pankratz V, Carrasquillo M, Rowley C, Nair A, Middha S, Maharjan S, Nguyen T, ... ... Younkin S, et al. O5-03-03: Genetic association of progressive supranuclear palsy (PSP) risk loci variants with brain gene expression and neuropathology endophenotypes Alzheimer's & Dementia. 8: P735-P735. DOI: 10.1016/J.Jalz.2012.05.1983  0.686
2012 Jager PD, Srivastava G, Eaton M, Chibnik L, Keenan B, Zou F, Song H, Younkin C, Younkin S, Ertekin-Taner N, Bernstein B, Meissner A, Kellis M, Bennett D. Genome-wide exploration of DNA methylation in the aging brain and its relation to Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1829  0.598
2012 Bisceglio G, Graff-Radford N, Talisha H, Ertekin-Taner N, Younkin S, Carrasquillo M. P4-123: The genetics of cognitively healthy aging Alzheimer's & Dementia. 8: P674-P675. DOI: 10.1016/J.Jalz.2012.05.1826  0.518
2012 Allen M, Pedraza O, Nguyen T, Bisceglio G, Flingai S, Miles R, Hirpa M, Ma L, Malphrus K, Petersen R, Graff-Radford N, Younkin S, Ertekin-Taner N. P3-257: Investigation of established Alzheimer's disease-risk SNPs for association with Alzheimer's disease in an African-American case control series Alzheimer's & Dementia. 8: P549-P550. DOI: 10.1016/J.Jalz.2012.05.1480  0.739
2012 Allen M, Zou F, Chai HS, Younkin C, Crook J, Pankratz V, Carrasquillo M, Rowley C, Nair A, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus K, Palusak R, ... ... Younkin S, et al. Genetic association of variants with late-onset Alzheimer's disease risk and brain gene expression Alzheimers & Dementia. 8: 451. DOI: 10.1016/J.Jalz.2012.05.1202  0.739
2011 Simmons CR, Zou F, Younkin SG, Estus S. Evaluation of the global association between cholesterol-associated polymorphisms and Alzheimer's disease suggests a role for rs3846662 and HMGCR splicing in disease risk. Molecular Neurodegeneration. 6: 62. PMID 21867541 DOI: 10.1186/1750-1326-6-62  0.444
2011 Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, ... ... Younkin SG, et al. Replication of EPHA1 and CD33 associations with late-onset Alzheimer's disease: a multi-centre case-control study. Molecular Neurodegeneration. 6: 54. PMID 21798052 DOI: 10.1186/1750-1326-6-54  0.383
2011 Belbin O, Crump M, Bisceglio GD, Carrasquillo MM, Morgan K, Younkin SG. Multiple insulin degrading enzyme variants alter in vitro reporter gene expression. Plos One. 6: e21429. PMID 21731745 DOI: 10.1371/Journal.Pone.0021429  0.396
2011 Ross OA, Rutherford NJ, Baker M, Soto-Ortolaza AI, Carrasquillo MM, DeJesus-Hernandez M, Adamson J, Li M, Volkening K, Finger E, Seeley WW, Hatanpaa KJ, Lomen-Hoerth C, Kertesz A, Bigio EH, ... ... Younkin SG, et al. Ataxin-2 repeat-length variation and neurodegeneration. Human Molecular Genetics. 20: 3207-12. PMID 21610160 DOI: 10.1093/Hmg/Ddr227  0.405
2011 Simmons CR, Zou F, Younkin SG, Estus S. Rheumatoid arthritis-associated polymorphisms are not protective against Alzheimer's disease. Molecular Neurodegeneration. 6: 33. PMID 21595938 DOI: 10.1186/1750-1326-6-33  0.446
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Younkin SG, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801  0.577
2011 Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Younkin SG, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803  0.395
2011 Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Sando SB, Aasly JO, Barcikowska M, Wszolek ZK, Dickson DW, Graff-Radford NR, Petersen RC, ... ... Younkin SG, et al. Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions. Journal of Alzheimer's Disease : Jad. 24: 751-8. PMID 21321396 DOI: 10.3233/Jad-2011-101932  0.408
2011 Belbin O, Brown K, Shi H, Medway C, Abraham R, Passmore P, Mann D, Smith AD, Holmes C, McGuinness B, Craig D, Warden D, Heun R, Kölsch H, Love S, ... ... Younkin S, et al. A multi-center study of ACE and the risk of late-onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 24: 587-97. PMID 21297258 DOI: 10.3233/Jad-2011-101914  0.413
2011 Yaffe K, Weston A, Graff-Radford NR, Satterfield S, Simonsick EM, Younkin SG, Younkin LH, Kuller L, Ayonayon HN, Ding J, Harris TB. Association of plasma beta-amyloid level and cognitive reserve with subsequent cognitive decline. Jama. 305: 261-6. PMID 21245181 DOI: 10.1001/Jama.2010.1995  0.326
2011 Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, ... ... Younkin S, et al. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Archives of Neurology. 68: 99-106. PMID 21220680 DOI: 10.1001/Archneurol.2010.346  0.449
2011 Burgess JD, Pedraza O, Graff-Radford NR, Hirpa M, Zou F, Miles R, Nguyen T, Li M, Lucas JA, Ivnik RJ, Crook J, Pankratz VS, Dickson DW, Petersen RC, Younkin SG, et al. Association of common KIBRA variants with episodic memory and AD risk. Neurobiology of Aging. 32: 557.e1-9. PMID 21185624 DOI: 10.1016/J.Neurobiolaging.2010.11.004  0.641
2011 Belbin O, Carrasquillo MM, Crump M, Culley OJ, Hunter TA, Ma L, Bisceglio G, Zou F, Allen M, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Investigation of 15 of the top candidate genes for late-onset Alzheimer's disease. Human Genetics. 129: 273-82. PMID 21132329 DOI: 10.1007/S00439-010-0924-2  0.604
2011 Alexander G, Hanna A, Serna V, Younkin L, Younkin S, Janus C. Increased aggression in males in transgenic Tg2576 mouse model of Alzheimer's disease Behavioural Brain Research. 216: 77-83. PMID 20655336 DOI: 10.1016/J.Bbr.2010.07.016  0.328
2011 Pedraza O, Allen M, Crook J, Ivnik R, Smith G, Knopman D, Pankratz V, Graff-Radford N, Roberts R, Petersen R, Younkin S, Ertekin-Taner N. P1-458: Differential association of memory endophenotypes to APOE alleles Alzheimer's & Dementia. 7: S260-S260. DOI: 10.1016/J.Jalz.2011.05.740  0.651
2011 Shi H, Medway C, Brown K, Kalsheker N, Goate A, Proitsi P, Powell J, Lovestone S, Carrasquillo M, Younkin S. Genetic Variants Influencing Human Longevity from Late-Onset Alzheimer’s Disease (LOAD) Genome-Wide Association Studies (GWAS) Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.542  0.339
2011 Pedraza O, Allen M, Jennette K, Crook J, Carrasquillo M, Palusak R, Nguyen T, Malphrus K, Ivnik R, Smith GE, Knopman D, Pankratz S, Graff-Radford N, Roberts R, Petersen R, ... Younkin S, et al. P1-252: Evaluation of Cognitive Endophenotypes for Association with CLU, CR1 and PICALM LOAD Risk Genes Alzheimer's & Dementia. 7: S191-S192. DOI: 10.1016/J.Jalz.2011.05.532  0.66
2011 Morgan K, Medway C, Hui S, Turton J, Bullock J, Brown K, Belbin O, Kalsheker N, Carrasquillo M, Younkin S. Differential Epistatic Interactions with Alternative APOE Alleles in Late-Onset Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.529  0.367
2011 Ertekin-Taner N, Zou F, Chai H, Younkin C, Crook J, Pankratz S, Allen M, Carrasquillo M, Rowley C, Pedraza O, Ansari M, Hayward C, Rudan I, Campbell H, Polasek O, ... ... Younkin S, et al. Genome-Wide Association Study of Brain Gene Expression Levels (eGWAS) Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.509  0.67
2011 Carrasquillo M, Olivia B, Talisha H, Ma L, Bisceglio G, Zou F, Crook J, Pankratz V, Sando S, Aasly J, Barcikowska M, Wszolek Z, Dickson D, Graff-Radford N, Petersen R, ... ... Younkin S, et al. P1-217: Replication of LOAD GWAS Associations Alzheimer's & Dementia. 7: S180-S181. DOI: 10.1016/J.Jalz.2011.05.496  0.318
2011 Allen M, Zou F, Chai HS, Younkin C, Crook J, Pankratz S, Carrasquillo M, Rowley C, Nair A, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus K, Palusak R, ... ... Younkin S, et al. O3-01-08: Evaluation of known Alzheimer's genes for SNPs that influence their brain expression (eSNPs) Alzheimer's & Dementia. 7: S498-S498. DOI: 10.1016/J.Jalz.2011.05.2392  0.696
2010 Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, ... ... Younkin SG, et al. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. American Journal of Human Genetics. 87: 890-7. PMID 21087763 DOI: 10.1016/J.Ajhg.2010.11.002  0.378
2010 Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Younkin SG, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/Journal.Pone.0013950  0.423
2010 Carrasquillo MM, Belbin O, Hunter TA, Ma L, Bisceglio GD, Zou F, Crook JE, Pankratz VS, Dickson DW, Graff-Radford NR, Petersen RC, Morgan K, Younkin SG. Replication of CLU, CR1, and PICALM associations with alzheimer disease. Archives of Neurology. 67: 961-4. PMID 20554627 DOI: 10.1001/Archneurol.2010.147  0.42
2010 Seshadri S, Fitzpatrick AL, Ikram MA, DeStefano AL, Gudnason V, Boada M, Bis JC, Smith AV, Carassquillo MM, Lambert JC, Harold D, Schrijvers EM, Ramirez-Lorca R, Debette S, Longstreth WT, ... ... Younkin SG, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. Jama. 303: 1832-40. PMID 20460622 DOI: 10.1001/Jama.2010.574  0.362
2010 Zou F, Carrasquillo MM, Pankratz VS, Belbin O, Morgan K, Allen M, Wilcox SL, Ma L, Walker LP, Kouri N, Burgess JD, Younkin LH, Younkin SG, Younkin CS, Bisceglio GD, ... ... Younkin SG, et al. Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease. Neurology. 74: 480-6. PMID 20142614 DOI: 10.1212/Wnl.0B013E3181D07654  0.722
2010 Carrasquillo MM, Belbin O, Zou F, Allen M, Ertekin-Taner N, Ansari M, Wilcox SL, Kashino MR, Ma L, Younkin LH, Younkin SG, Younkin CS, Dincman TA, Howard ME, Howell CC, ... ... Younkin SG, et al. Concordant association of insulin degrading enzyme gene (IDE) variants with IDE mRNA, Abeta, and Alzheimer's disease. Plos One. 5: e8764. PMID 20098734 DOI: 10.1371/Journal.Pone.0008764  0.735
2010 Palusak R, Zou F, Miles R, Carrasquillo M, Ma L, Nguyen T, Dickson D, Petersen RC, Graff-Radford NR, Younkin SG, Ertekin-Taner N. P1-102: Investigating cis-SNP/mRNA level associations of candidate Alzheimer genes in different brain regions of patients and controls Alzheimer's & Dementia. 6: S204-S204. DOI: 10.1016/J.Jalz.2010.05.651  0.611
2010 Ertekin-Taner N, Burgess J, Hirpa M, Nguyen T, Li M, Fanggeng Z, Younkin SG, Crook JE, Pankratz V, Petersen RC, Graff-Radford NR, Pedraza O. P1-098: Association of common KIBRA variants with episodic memory and Alzheimer risk Alzheimer's & Dementia. 6: S203-S203. DOI: 10.1016/J.Jalz.2010.05.646  0.594
2010 Miles RJ, DelleDonne A, Zou F, Murray M, Ma L, Nguyen T, Bisceglio G, Dickson DW, Younkin S, Leissring MA, Ertekin-Taner N. P1-095: Characterization of brain region- and disease-specific IDE expression in Alzheimer patients and controls Alzheimer's & Dementia. 6: S202-S202. DOI: 10.1016/J.Jalz.2010.05.643  0.604
2010 Allen M, Cox C, Belbin O, Ma L, Bisceglio GD, Wilcox SL, Howell CC, Hunter TA, Culley O, Walker LP, Carrasquillo MM, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG, et al. P1-058: Association of glyceraldehyde-3-phosphate dehydrogenase locus variant with late-onset Alzheimer's disease Alzheimer's & Dementia. 6: S190-S190. DOI: 10.1016/J.Jalz.2010.05.606  0.742
2010 Graff-Radford NR, Crook JE, Lucas JA, Younkin LH, Nah G, Younkin SG, Haan MN. O4-06-05: Association of Aβ42, Aβ40 and Aβ2/Aβ40 with cognitive impairment not demented (CIND) and dementia in persons of mexican ancestry (SALSA study): Different for diabetics versus non-diabetics? Alzheimer's & Dementia. 6: S161-S161. DOI: 10.1016/J.Jalz.2010.05.500  0.333
2010 Zou F, Allen M, Belbin O, Hunter T, Ma L, Bisceglio G, Carrasquillo M, Younkin C, Petersen R, Graff-Radford N, Dickson D, Deak F, Younkin S. O2-07-07: eSNPs within VAMP1 show genetic association with late onset Alzheimer's disease Alzheimer's & Dementia. 6: S114-S114. DOI: 10.1016/J.Jalz.2010.05.352  0.606
2010 Reitz C, Cheng R, Rogaeva E, Lee J, Tokuhiro S, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Kamboh IM, Prince J, Maier W, Riemenschneider M, Owen M, ... ... Younkin S, et al. Meta-analysis of the association between SORL1 variants and Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.351  0.48
2010 Younkin S. The X-chromosome and Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.196  0.367
2010 Weston AL, Hou N, Graff-Radford N, Satterfield S, Harris T, Kuller L, Simonsick E, Ayonayon H, Dong J, Younkin L, Younkin S, Yaffe K. The plasma Aβ42/Aβ40 ratio: A promising biomarker for cognitive decline Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1691  0.322
2010 Machulda MM, Jones DT, McDade EM, Vemuri P, Avula R, Przybelski SA, Younkin S, Senjem M, Gunter J, Boeve BF, Knopman D, Petersen RC, Jack CR. IC-P-145: Effect of APOE4 Status and Alzheimer's Disease on Posterior Cingulate Connectivity Alzheimer's & Dementia. 6: S57-S57. DOI: 10.1016/J.Jalz.2010.05.160  0.405
2010 Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG. Genetic variation in PCDH11X is associated with susceptibility to late onset alzheimer's disease Hirosaki Medical Journal. 61: S125-S134.  0.596
2010 Younkin S. Current concepts in alzheimer's disease Hirosaki Medical Journal. 61: S97-S104.  0.304
2009 Grear KE, Ling IF, Simpson JF, Furman JL, Simmons CR, Peterson SL, Schmitt FA, Markesbery WR, Liu Q, Crook JE, Younkin SG, Bu G, Estus S. Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain. Molecular Neurodegeneration. 4: 46. PMID 19889229 DOI: 10.1186/1750-1326-4-46  0.464
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Younkin SG, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/Ng.440  0.453
2009 Verwey NA, van der Flier WM, Blennow K, Clark C, Sokolow S, De Deyn PP, Galasko D, Hampel H, Hartmann T, Kapaki E, Lannfelt L, Mehta PD, Parnetti L, Petzold A, Pirttila T, ... ... Younkin S, et al. A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease. Annals of Clinical Biochemistry. 46: 235-40. PMID 19342441 DOI: 10.1258/Acb.2009.008232  0.389
2009 Finch N, Baker M, Crook R, Swanson K, Kuntz K, Surtees R, Bisceglio G, Rovelet-Lecrux A, Boeve B, Petersen RC, Dickson DW, Younkin SG, Deramecourt V, Crook J, Graff-Radford NR, et al. Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members. Brain : a Journal of Neurology. 132: 583-91. PMID 19158106 DOI: 10.1093/Brain/Awn352  0.321
2009 Carrasquillo MM, Zou F, Pankratz VS, Wilcox SL, Ma L, Walker LP, Younkin SG, Younkin CS, Younkin LH, Bisceglio GD, Ertekin-Taner N, Crook JE, Dickson DW, Petersen RC, Graff-Radford NR, ... Younkin SG, et al. Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. Nature Genetics. 41: 192-8. PMID 19136949 DOI: 10.1016/J.Jalz.2009.05.518  0.597
2009 Relkin NR, Szabo P, Adamiak B, Burgut T, Monthe C, Lent RW, Younkin S, Younkin L, Schiff R, Weksler ME. 18-Month study of intravenous immunoglobulin for treatment of mild Alzheimer disease. Neurobiology of Aging. 30: 1728-36. PMID 18294736 DOI: 10.1016/J.Neurobiolaging.2007.12.021  0.415
2009 Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Younkin SG, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 41: 1156-1156. DOI: 10.1038/Ng1009-1156D  0.342
2009 Allen M, Ansari M, Younkin L, Hayward C, Vitart V, Campbell S, Huffman J, Morgan J, Polasek O, Hastie ND, Rudan I, Campbell H, Younkin SG, Wright A. O4-01-03: Genome-Wide Association Study (GWAS) of plasma Aß levels in the dalmatian islands of Vis and korcula Alzheimer's & Dementia. 5: P149-P149. DOI: 10.1016/J.Jalz.2009.05.515  0.508
2009 Harold D, Hollingworth P, Hamshere M, Holmans P, Abraham R, Sims R, Gerrish A, Lovestone S, Brayne C, Gill M, Lawlor B, Passmore P, Nothen M, Maier W, Livingston G, ... ... Younkin S, et al. P4-133: Genome-wide association study of age at onset of Alzheimer's disease Alzheimer's & Dementia. 5: P471-P471. DOI: 10.1016/J.Jalz.2009.04.801  0.45
2009 Belbin O, Carrasquillo M, Zou F, Allen M, Ertekin-Taner N, Brown K, Passmore P, Craig D, McGuinness B, Todd S, Kehoe PG, Mann DM, Smith AD, Beaumont H, Warden D, ... ... Younkin SG, et al. P4-130: Concordant association of functional IDE variant with IDE mRNA, Aß, and Alzheimer's disease Alzheimer's & Dementia. 5: P469-P470. DOI: 10.1016/J.Jalz.2009.04.798  0.728
2009 Burgess J, Leissring MA, Ma L, Younkin LH, Reinstatler L, Crook JE, Pankratz VS, Dickson DW, Peterson RC, Graff-Radford NR, Younkin SG, Ertekin-Taner N. P4-128: Association of a missense cathepsin D (CTSD) SNP with risk of Alzheimer's disease Alzheimer's & Dementia. 5: P469-P469. DOI: 10.1016/J.Jalz.2009.04.796  0.642
2009 Graff-Radford NR, Crook JE, Lucas JA, Younkin LH, Moore KA, Younkin SG, Haan MN. P3-122: High plasma Aβ 40 levels are associated with incident Cognitive Impairment not Demented (CIND) and dementia cases in persons of Mexican ancestry (SALSA study) Alzheimer's & Dementia. 5: P380-P380. DOI: 10.1016/J.Jalz.2009.04.1097  0.33
2008 Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price RW, Smithson L, Sonoda L, Wagg K, Rangachari V, Zou F, ... Younkin SG, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6030-6. PMID 18524908 DOI: 10.1523/Jneurosci.0891-08.2008  0.721
2008 Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 71: 85-92. PMID 18509095 DOI: 10.1212/01.Wnl.0000303973.71803.81  0.313
2008 Park L, Zhou P, Pitstick R, Capone C, Anrather J, Norris EH, Younkin L, Younkin S, Carlson G, McEwen BS, Iadecola C. Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 105: 1347-52. PMID 18202172 DOI: 10.1073/Pnas.0711568105  0.41
2008 Zou F, Gopalraj RK, Lok J, Zhu H, Ling IF, Simpson JF, Tucker HM, Kelly JF, Younkin SG, Dickson DW, Petersen RC, Graff-Radford NR, Bennett DA, Crook JE, Younkin SG, et al. Sex-dependent association of a common low-density lipoprotein receptor polymorphism with RNA splicing efficiency in the brain and Alzheimer's disease. Human Molecular Genetics. 17: 929-35. PMID 18065781 DOI: 10.1093/Hmg/Ddm365  0.425
2008 Ertekin-Taner N, Younkin LH, Yager DM, Parfitt F, Baker MC, Asthana S, Hutton ML, Younkin SG, Graff-Radford NR. Plasma amyloid beta protein is elevated in late-onset Alzheimer disease families. Neurology. 70: 596-606. PMID 17914065 DOI: 10.1212/01.Wnl.0000278386.00035.21  0.591
2008 Zhu H, Taylor JW, Bennett DA, Younkin SG, Estus S. Lack of association of hepatic lipase polymorphisms with late-onset Alzheimer's disease. Neurobiology of Aging. 29: 793-4. PMID 17175070 DOI: 10.1016/J.Neurobiolaging.2006.11.015  0.414
2008 Younkin LH, Brehm-Gibson TL, Bisceglio GD, Graff-Radford NR, Younkin SG. P1-370: Reduction of interference in sandwich ELISAs measuring the amyloid β protein in human plasma Alzheimer's & Dementia. 4: T327-T327. DOI: 10.1016/J.Jalz.2008.05.952  0.313
2008 Wilcox S, Carrasquillo M, Younkin S, Li M, Bisceglio G, Zou F, Walker L, Allen M, Younkin L, Dickson D, Graff-Radford N, Petersen R, Younkin S. O2-06-04: Identification of late-onset Alzheimer's disease (LOAD) susceptibility alleles in the PAI-1 gene Alzheimer's & Dementia. 4: T144-T144. DOI: 10.1016/J.Jalz.2008.05.352  0.613
2008 Zou F, Kim J, Miller VM, Levites Y, Ma L, Cangemi D, Bisceglio G, Younkin S, Pankratz VS, Petersen RC, Graff-Radford N, Dickson D, Rosenberry T, Golde T, Younkin SG. P3-276: BRI2 (ITM2B) shows genetic association with late-onset Alzheimer's disease Alzheimer's & Dementia. 4: T603-T603. DOI: 10.1016/J.Jalz.2008.05.1844  0.736
2008 Younkin SG, Carrasquillo M, Younkin S, Zou F, Walker LP, Wilcox S, Younkin C, Pishotta FT, Ma L, Bisceglio G, Kouri N, Pankratz VS, Cunningham JM, Petersen RC, Graff-Radford NR, et al. P3-275: Genome-wide association study for Braak neurofibrillary tangle (NFT) staging Alzheimer's & Dementia. 4: T602-T603. DOI: 10.1016/J.Jalz.2008.05.1843  0.568
2008 Walker L, Allen M, Cox C, Younkin S, Younkin L, Carrasquillo M, Zou F, Ma L, Kouri N, Pankratz VS, Dickson D, Boeve B, Petersen RC, Graff-Radford NR, Younkin SG, et al. P3-271: Association of candidate gene susceptibility alleles on chromosome 10 with Alzheimer's disease risk and endophenotypes Alzheimer's & Dementia. 4: T601-T601. DOI: 10.1016/J.Jalz.2008.05.1839  0.727
2008 Rogaeva E, Lee JH, Meng Y, Wakutani Y, Zou F, Moreno D, Cheng R, Sorbi S, Bruni A, Duara R, Graff-Radford N, Petersen RC, Dickson D, Younkin S, Farrer LA, et al. P3-258: Further evidence of genetic association between SORL1 and Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1826  0.468
2008 Morgan K, Carrasquillo M, Belbin O, Brown K, Kalsheker N, Craig D, McGuinness B, Passmore P, Heun R, Koelsch H, Kehoe P, Mann D, Warden D, Beaumont H, Smith D, ... ... Younkin S, et al. P3-244: Insulin degrading enzyme and the risk of late-onset Alzheimer's disease: A large replication study in a European population Alzheimer's & Dementia. 4: T592-T592. DOI: 10.1016/J.Jalz.2008.05.1811  0.388
2008 Ertekin-Taner N, Zou F, Carrasquillo M, Younkin S, Ma L, Walker LP, Wilcox S, Bisceglio G, Kouri N, Pankratz VS, Cunningham JM, Dickson D, Petersen RC, Graff-Radford NR, Younkin SG. P3-216: Identification of CIS variants associating with expression levels of 12 late-onset Alzheimer's disease (LOAD) candidate genes in a Genome-Wide Association Study (GWAS) Alzheimer's & Dementia. 4: T584-T584. DOI: 10.1016/J.Jalz.2008.05.1783  0.657
2008 Carrasquillo MM, Younkin SG, Zou F, Ma L, Wilcox SL, Walker LP, Bisceglio G, Ertekin-Taner N, Pankratz VS, Cunningham JM, Dickson DW, Petersen RC, Graff-Radford NR, Younkin SG. P3-208: Genetic variation in PCDH11X associates with Alzheimer's disease in a two-stage GWAS study Alzheimer's & Dementia. 4: T581-T582. DOI: 10.1016/J.Jalz.2008.05.1775  0.636
2008 Miller VM, Kim J, Zou F, Levites Y, Jansen-West K, Zwizinski CW, Moore BD, Troendle FJ, Bann M, Verbeeck C, Price R, Smithson L, Rangachari V, Sonoda L, Wagg K, ... ... Younkin SG, ... ... Younkin SG, et al. P2-347: BRI2 (ITM2B) inhibits Aβ deposition Alzheimer's & Dementia. 4: T474-T475. DOI: 10.1016/J.Jalz.2008.05.1424  0.678
2008 WEKSLER M, SZABO P, ADAMIAK B, BURGUT T, MONTHE C, YOUNKIN S, YOUNKIN L, RELKIN N. Infusion of Intravenous Immunoglobulin (IVIg) Containing anti-Abeta Antibodies is Associated with a Decrease of Abeta in Cerebrospinal Fluid (CSF) and Increase of Abeta in Blood from 8 Patients with Mild Alzheimer's Disease (AD) Journal of Allergy and Clinical Immunology. 121: S212-S212. DOI: 10.1016/J.Jaci.2007.12.792  0.42
2007 Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR. Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice. The Journal of Biological Chemistry. 282: 22707-20. PMID 17556372 DOI: 10.1074/Jbc.M611050200  0.352
2007 Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 104: 8167-72. PMID 17470798 DOI: 10.1073/Pnas.0609521104  0.357
2007 Graff-Radford NR, Crook JE, Lucas J, Boeve BF, Knopman DS, Ivnik RJ, Smith GE, Younkin LH, Petersen RC, Younkin SG. Association of low plasma Abeta42/Abeta40 ratios with increased imminent risk for mild cognitive impairment and Alzheimer disease. Archives of Neurology. 64: 354-62. PMID 17353377 DOI: 10.1001/Archneur.64.3.354  0.428
2007 Rogaeva E, Meng Y, Lee JH, Gu Y, Kawarai T, Zou F, Katayama T, Baldwin CT, Cheng R, Hasegawa H, Chen F, Shibata N, Lunetta KL, Pardossi-Piquard R, Bohm C, ... ... Younkin S, et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. Nature Genetics. 39: 168-77. PMID 17220890 DOI: 10.1038/Ng1943  0.491
2006 Harigaya Y, Tomidokoro Y, Ikeda M, Sasaki A, Kawarabayashi T, Matsubara E, Kanai M, Saido TC, Younkin SG, Shoji M. Type-specific evolution of amyloid plaque and angiopathy in APPsw mice. Neuroscience Letters. 395: 37-41. PMID 16298484 DOI: 10.1016/J.Neulet.2005.10.087  0.382
2006 Reddy JS, Allen M, Wang X, Biernacka JM, Gregory JD, Toral SM, McDonnell SK, Sarangi V, Sinnwell JP, Asmann YW, Carrasquillo MM, Pottier CP, Ren Y, Younkin CS, Rademakers R, ... ... Younkin SG, et al. O3-06-02: POLYGENIC SCORE ANALYSIS OF EXONIC VARIANTS IN AN IMMUNE CO-REGULATORY NETWORK IDENTIFIES NOVEL PROTEIN-ALTERING VARIANTS THAT ASSOCIATE WITH ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1025-P1026. DOI: 10.1016/J.Jalz.2018.06.2801  0.703
2006 Ertekin-Taner N, Allen M, Younkin L, Carrasquillo M, Younkin S, Greene MH, Kashino M, Singhal S, Dincman T, Petersen R, Graff-Radford N, Younkin SG. P1-353: Associaton of VR22 and LRRTM3 variants with late onset Alzheimer's disease (LOAD) and amyloid beta levels Alzheimer's & Dementia. 2: S201-S201. DOI: 10.1016/J.Jalz.2006.05.731  0.738
2006 Carrasquillo MM, Younkin SG, Kashino MR, Wilcox SL, Dincman TA, Howard ME, Li M, Zou F, Ertekin-Taner N, Allen M, Stanton CM, Watson CM, Younkin LH, Petersen RC, Graff-Radford N, ... Younkin SG, et al. P1-310: Late onset Alzheimer's disease (LOAD) susceptibility alleles in the insulin-degrading-enzyme gene (IDE ) and other Aβ-degrading enzymes Alzheimer's & Dementia. 2: S187-S187. DOI: 10.1016/J.Jalz.2006.05.688  0.703
2006 Younkin LH, Dincman T, Lok J, Raam M, Zou F, Carrasquillo M, Ma L, Budjak R, Younkin S, Petersen R, Graff-Radford N, Younkin S. P1-308: Association of variants in Aβ processing genes with late onset Alzheimer’s disease (LOAD) Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.686  0.461
2006 Relkin NR, Younkin L, Younkin S, Monthe C, Adamiak B, Szabo P, Schiff R, Weksler M. P4-251: Decreased plasma beta amyloid levels in Alzheimer patients treated chronically with Intravenous immunoglobulin (IVIG) Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1990  0.373
2006 Graff-Radford NR, Weigand SD, Shuing MM, Knopman DS, Boeve BF, Lucas JA, Crook JE, Younkin LH, Petersen RC, Jack CR, Younkin SG. P3-102: Annualized decrease in plasma Aβ42 correlates with annualized decrease in hippocampal volume Alzheimer's & Dementia. 2: S403-S403. DOI: 10.1016/J.Jalz.2006.05.1370  0.308
2006 Ringman JM, Cole G, Geschwind D, Schaffer B, Rodriguez Y, Fein J, Medina L, Pratico D, Younkin S, Cummings JL. P2-164: Biochemical markers in blood and cerebrospinal fluid of persons with or at-risk for familial AD Alzheimer's & Dementia. 2: S282-S282. DOI: 10.1016/J.Jalz.2006.05.1002  0.34
2005 Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR. Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. Plos Medicine. 2: e355. PMID 16279840 DOI: 10.1371/Journal.Pmed.0020355  0.42
2005 Rees TM, Berson A, Sklan EH, Younkin L, Younkin S, Brimijoin S, Soreq H. Memory deficits correlating with acetylcholinesterase splice shift and amyloid burden in doubly transgenic mice. Current Alzheimer Research. 2: 291-300. PMID 15974894 DOI: 10.2174/1567205054367847  0.379
2005 Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV. Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5217-24. PMID 15917461 DOI: 10.1523/Jneurosci.5080-04.2005  0.397
2005 Wang DS, Lipton RB, Katz MJ, Davies P, Buschke H, Kuslansky G, Verghese J, Younkin SG, Eckman C, Dickson DW. Decreased neprilysin immunoreactivity in Alzheimer disease, but not in pathological aging. Journal of Neuropathology and Experimental Neurology. 64: 378-85. PMID 15892294 DOI: 10.1093/Jnen/64.5.378  0.43
2005 Park L, Anrather J, Zhou P, Frys K, Pitstick R, Younkin S, Carlson GA, Iadecola C. NADPH-oxidase-derived reactive oxygen species mediate the cerebrovascular dysfunction induced by the amyloid beta peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1769-77. PMID 15716413 DOI: 10.1523/Jneurosci.5207-04.2005  0.393
2005 Ertekin-Taner N, Ronald J, Feuk L, Prince J, Tucker M, Younkin L, Hella M, Jain S, Hackett A, Scanlin L, Kelly J, Kihiko-Ehman M, Neltner M, Hersh L, Kindy M, ... ... Younkin SG, et al. Elevated amyloid beta protein (Abeta42) and late onset Alzheimer's disease are associated with single nucleotide polymorphisms in the urokinase-type plasminogen activator gene. Human Molecular Genetics. 14: 447-60. PMID 15615772 DOI: 10.1093/Hmg/Ddi041  0.653
2005 Graff-Radford NR, Lucas JA, Crook JE, Boeve BF, Knopman DS, Ivnik RJ, Younkin LH, Petersen RC, Younkin SG. Plasma AB levels as a premorbid biomarker for cognitive decline, mild cognitive impairment (MCI) and Alzheimer disease (AD) Alzheimers & Dementia. 1. DOI: 10.1016/J.Jalz.2005.06.073  0.342
2005 Younkin S. Natural history of amyloid-beta peptides in the CNS and periphery Alzheimers & Dementia. 1. DOI: 10.1016/J.Jalz.2005.06.029  0.3
2004 Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT. Altered amyloid-β metabolism and deposition in genomic-based β-secretaee transgenic mice Journal of Biological Chemistry. 279: 52535-52542. PMID 15452128 DOI: 10.1074/Jbc.M409680200  0.324
2004 Tucker HM, Simpson J, Kihiko-Ehmann M, Younkin LH, McGillis JP, Younkin SG, Degen JL, Estus S. Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neuroscience Letters. 368: 285-9. PMID 15364412 DOI: 10.1016/J.Neulet.2004.07.011  0.328
2004 Krezowski J, Knudson D, Ebeling C, Pitstick R, Giri RK, Schenk D, Westaway D, Younkin L, Younkin SG, Ashe KH, Carlson GA. Identification of loci determining susceptibility to the lethal effects of amyloid precursor protein transgene overexpression. Human Molecular Genetics. 13: 1989-97. PMID 15254013 DOI: 10.1093/Hmg/Ddh210  0.394
2004 Kawarabayashi T, Shoji M, Younkin LH, Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG. Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3801-9. PMID 15084661 DOI: 10.1523/Jneurosci.5543-03.2004  0.417
2004 Ertekin-Taner N, Allen M, Fadale D, Scanlin L, Younkin L, Petersen RC, Graff-Radford N, Younkin SG. Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease. Human Mutation. 23: 334-42. PMID 15024728 DOI: 10.1002/Humu.20016  0.731
2004 Ikarashi Y, Harigaya Y, Tomidokoro Y, Kanai M, Ikeda M, Matsubara E, Kawarabayashi T, Kuribara H, Younkin SG, Maruyama Y, Shoji M. Decreased level of brain acetylcholine and memory disturbance in APPsw mice. Neurobiology of Aging. 25: 483-90. PMID 15013569 DOI: 10.1016/S0197-4580(03)00122-2  0.32
2004 Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 41: 27-33. PMID 14715132 DOI: 10.1016/S0896-6273(03)00810-9  0.433
2004 Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Human Molecular Genetics. 13: 159-70. PMID 14645205 DOI: 10.1093/Hmg/Ddh019  0.416
2004 Elesber AA, Bonetti P, Herrmann J, Woodrum J, Younkin S, Lerman LO, Lerman A. 1027-189 Chronic endothelin receptor antagonism preserves endothelial function in a transgenic mouse model of alzheimer's disease Journal of the American College of Cardiology. 43: A451. DOI: 10.1016/S0735-1097(04)91902-X  0.357
2004 Kotilinek LA, Wang Q, Westerman mA, Lim GP, Falinska A, Simonyi A, Younkin LH, Younkin SG, Sun GY, Rowan M, Cleary J, Frautschy SA, Cole GM, Anwyl R, Ashe KH. P4-368 NSAIDS improve amyloid beta protein-induced deficits in memory and synaptic plasticity Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81926-2  0.302
2004 Ertekin-Taner N, Ronald J, Allen M, Prince JA, Feuk L, Fadale D, Scanlin L, Asahara H, Younkin L, Hella M, Jain S, Gnida E, Stanton C, Younkin S, Ohyagi Y, ... ... Younkin SG, et al. P4-095 Analysis of Alzheimer's disease candidate genes on chromosome 10 Neurobiology of Aging. 25: S501. DOI: 10.1016/S0197-4580(04)81653-1  0.711
2004 Graff-Radford NR, Lucas JA, Petersen RC, Younkin LH, Younkin SG. P3-011 Analysis of plasma Aβ42 ASA premorbid biomarker for late onset Alzheimer's disease Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81166-7  0.459
2004 Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. P2-037 Genetic evidence for therapeutic inhibition of BACE1 in an Alzheimer's mouse model Neurobiology of Aging. 25: S234. DOI: 10.1016/S0197-4580(04)80784-X  0.399
2003 Ertekin-Taner N, Ronald J, Asahara H, Younkin L, Hella M, Jain S, Gnida E, Younkin S, Fadale D, Ohyagi Y, Singleton A, Scanlin L, de Andrade M, Petersen R, Graff-Radford N, ... ... Younkin S, et al. Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Human Molecular Genetics. 12: 3133-43. PMID 14559775 DOI: 10.1093/Hmg/Ddg343  0.643
2003 Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse. Human Molecular Genetics. 12: 2949-56. PMID 14506131 DOI: 10.1093/Hmg/Ddg322  0.395
2003 McMahon BM, Stewart J, Fauq A, Younkin S, Younkin L, Richelson E. Peptide nucleic acids targeted to the amyloid precursor protein. Journal of Molecular Neuroscience : Mn. 20: 261-5. PMID 14501006 DOI: 10.1385/Jmn:20:3:261  0.413
2003 McMahon BM, Stewart J, Fauq A, Younkin S, Younkin L, Richelson E. Using peptide nucleic acids as gene-expression modifiers to reduce beta-amyloid levels. Journal of Molecular Neuroscience : Mn. 19: 71-6. PMID 12212797 DOI: 10.1007/S12031-002-0013-7  0.388
2002 Arvanitakis Z, Lucas JA, Younkin LH, Younkin SG, Graff-Radford NR. Serum creatinine levels correlate with plasma amyloid Beta protein. Alzheimer Disease and Associated Disorders. 16: 187-90. PMID 12218650 DOI: 10.1097/00002093-200207000-00009  0.414
2002 Basun H, Nilsberth C, Eckman C, Lannfelt L, Younkin S. Plasma levels of Abeta42 and Abeta40 in Alzheimer patients during treatment with the acetylcholinesterase inhibitor tacrine. Dementia and Geriatric Cognitive Disorders. 14: 156-60. PMID 12218259 DOI: 10.1159/000063605  0.385
2002 Niwa K, Kazama K, Younkin L, Younkin SG, Carlson GA, Iadecola C. Cerebrovascular autoregulation is profoundly impaired in mice overexpressing amyloid precursor protein. American Journal of Physiology. Heart and Circulatory Physiology. 283: H315-23. PMID 12063304 DOI: 10.1152/Ajpheart.00022.2002  0.37
2002 Amtul Z, Lewis PA, Piper S, Crook R, Baker M, Findlay K, Singleton A, Hogg M, Younkin L, Younkin SG, Hardy J, Hutton M, Boeve BF, Tang-Wai D, Golde TE. A presenilin 1 mutation associated with familial frontotemporal dementia inhibits gamma-secretase cleavage of APP and notch. Neurobiology of Disease. 9: 269-73. PMID 11895378 DOI: 10.1006/Nbdi.2001.0473  0.541
2002 Niwa K, Kazama K, Younkin SG, Carlson GA, Iadecola C. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiology of Disease. 9: 61-8. PMID 11848685 DOI: 10.1006/Nbdi.2001.0460  0.382
2002 Wahrle S, Das P, Nyborg AC, McLendon C, Shoji M, Kawarabayashi T, Younkin LH, Younkin SG, Golde TE. Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiology of Disease. 9: 11-23. PMID 11848681 DOI: 10.1006/Nbdi.2001.0470  0.526
2002 Kotilinek LA, Bacskai B, Westerman M, Kawarabayashi T, Younkin L, Hyman BT, Younkin S, Ashe KH. Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease The Journal of Neuroscience. 22: 6331-6335. DOI: 10.1523/Jneurosci.22-15-06331.2002  0.379
2002 Westerman MA, Cooper-Blacketer D, Mariash A, Kotilinek L, Kawarabayashi T, Younkin LH, Carlson GA, Younkin SG, Ashe KH. The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease The Journal of Neuroscience. 22: 1858-1867. DOI: 10.1523/Jneurosci.22-05-01858.2002  0.365
2001 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Reduced effectiveness of Abeta1-42 immunization in APP transgenic mice with significant amyloid deposition. Neurobiology of Aging. 22: 721-7. PMID 11705631 DOI: 10.1016/S0197-4580(01)00245-7  0.549
2001 Clarke NJ, Crow FW, Younkin S, Naylor S. Analysis of in vivo-derived amyloid-beta polypeptides by on-line two-dimensional chromatography-mass spectrometry. Analytical Biochemistry. 298: 32-9. PMID 11673892 DOI: 10.1006/Abio.2001.5357  0.356
2001 Nilsberth C, Westlind-Danielsson A, Eckman CB, Condron MM, Axelman K, Forsell C, Stenh C, Luthman J, Teplow DB, Younkin SG, Näslund J, Lannfelt L. The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation. Nature Neuroscience. 4: 887-93. PMID 11528419 DOI: 10.1038/Nn0901-887  0.419
2001 Tomidokoro Y, Harigaya Y, Matsubara E, Ikeda M, Kawarabayashi T, Shirao T, Ishiguro K, Okamoto K, Younkin SG, Shoji M. Brain Abeta amyloidosis in APPsw mice induces accumulation of presenilin-1 and tau. The Journal of Pathology. 194: 500-6. PMID 11523060 DOI: 10.1002/Path.897  0.418
2001 Haugabook SJ, Yager DM, Eckman EA, Golde TE, Younkin SG, Eckman CB. High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid beta peptide (Abeta). Journal of Neuroscience Methods. 108: 171-9. PMID 11478976 DOI: 10.1016/S0165-0270(01)00388-0  0.564
2001 Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Adamson J, Schaid DJ, Blangero J, Hutton M, Younkin SG. Heritability of plasma amyloid beta in typical late-onset Alzheimer's disease pedigrees. Genetic Epidemiology. 21: 19-30. PMID 11443731 DOI: 10.1002/Gepi.1015  0.622
2001 Golde TE, Younkin SG. Presenilins as therapeutic targets for the treatment of Alzheimer's disease. Trends in Molecular Medicine. 7: 264-9. PMID 11378516 DOI: 10.1016/S1471-4914(01)02064-0  0.593
2001 Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-dependent changes in brain, CSF, and plasma amyloid (beta) protein in the Tg2576 transgenic mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 372-81. PMID 11160418  0.311
2001 Younkin SG. Amyloid beta vaccination: reduced plaques and improved cognition. Nature Medicine. 7: 18-9. PMID 11135604 DOI: 10.1038/83929  0.379
2001 Haugabook SJ, Le T, Yager D, Zenk B, Healy BM, Eckman EA, Prada C, Younkin L, Murphy P, Pinnix I, Onstead L, Sambamurti K, Golde TE, Dickson D, Younkin SG, et al. Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 16-18. PMID 11099491 DOI: 10.1096/Fj.00-0528Fje  0.591
2001 Kawarabayashi T, Younkin LH, Saido TC, Shoji M, Ashe KH, Younkin SG. Age-Dependent Changes in Brain, CSF, and Plasma Amyloid β Protein in the Tg2576 Transgenic Mouse Model of Alzheimer's Disease The Journal of Neuroscience. 21: 372-381. DOI: 10.1523/Jneurosci.21-02-00372.2001  0.443
2000 Ertekin-Taner N, Graff-Radford N, Younkin LH, Eckman C, Baker M, Adamson J, Ronald J, Blangero J, Hutton M, Younkin SG. Linkage of plasma Abeta42 to a quantitative locus on chromosome 10 in late-onset Alzheimer's disease pedigrees. Science (New York, N.Y.). 290: 2303-4. PMID 11125143 DOI: 10.1126/Science.290.5500.2303  0.634
2000 Harigaya Y, Saido TC, Eckman CB, Prada CM, Shoji M, Younkin SG. Amyloid beta protein starting pyroglutamate at position 3 is a major component of the amyloid deposits in the Alzheimer's disease brain. Biochemical and Biophysical Research Communications. 276: 422-7. PMID 11027491 DOI: 10.1006/Bbrc.2000.3490  0.431
2000 Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Ashe KH, Carlson GA, Iadecola C. Aβ1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Proceedings of the National Academy of Sciences of the United States of America. 97: 9735-9740. PMID 10944232 DOI: 10.1073/Pnas.97.17.9735  0.391
2000 Fagan AM, Younkin LH, Morris JC, Fryer JD, Cole TG, Younkin SG, Holtzman DM. Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype. Annals of Neurology. 48: 201-10. PMID 10939571 DOI: 10.1002/1531-8249(200008)48:2<201::Aid-Ana10>3.0.Co;2-X  0.397
2000 Golde TE, Eckman CB, Younkin SG. Biochemical detection of Abeta isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer's disease. Biochimica Et Biophysica Acta. 1502: 172-87. PMID 10899442 DOI: 10.1016/S0925-4439(00)00043-0  0.608
2000 Greenberg SM, Cho HS, O'Donnell HC, Rosand J, Segal AZ, Younkin LH, Younkin SG, Rebeck GW. Plasma beta-amyloid peptide, transforming growth factor-beta 1, and risk for cerebral amyloid angiopathy. Annals of the New York Academy of Sciences. 903: 144-9. PMID 10818500 DOI: 10.1111/J.1749-6632.2000.Tb06361.X  0.341
2000 Ohyagi Y, Yamada T, Nishioka K, Clarke NJ, Tomlinson AJ, Naylor S, Nakabeppu Y, Kira J, Younkin SG. Selective increase in cellular A beta 42 is related to apoptosis but not necrosis. Neuroreport. 11: 167-71. PMID 10683851 DOI: 10.1097/00001756-200001170-00033  0.316
2000 Basun H, Eckman CB, Nilsberth C, Lannfelt L, Younkin SG. Plasma Aβ40 and Aβ42 in Alzheimer's patients during treatment with tacrine Neurobiology of Aging. 21: 91. DOI: 10.1016/S0197-4580(00)82632-9  0.39
2000 Nilsberth C, Westlind-Danielsson A, Eckman CB, Forsell C, Axelman K, Luthman J, Younkin SG, Nšslund J. The Arctic APP mutation (E693G) causes Alzheimer's disease through a novel mechanism: Increased amyloid βprotfibril formation and decreased amyloid βlevels in plasma and conditioned media Neurobiology of Aging. 21: 58. DOI: 10.1016/S0197-4580(00)82487-2  0.43
2000 Younkin SG, Taner NE, Xin T, Baker M, Younkin LH, Hutton M, Graff-Radford N. Role of elevated amyloid β protein in patients with typical late onset Alzheimer's disease Neurobiology of Aging. 21: 136. DOI: 10.1016/S0197-4580(00)82409-4  0.423
2000 Taner NE, Graff-Radford N, Younkin LH, Hutton ML, Younkin SG. Linkage analysis of plasma amyloid β protein in typical late onset Alzheimer disease (load) Neurobiology of Aging. 21: 130. DOI: 10.1016/S0197-4580(00)82382-9  0.414
2000 Das P, Murphy MP, Younkin LH, Younkin SG, Golde TE. Aβ42 deposition is selectively altered in brains of Aβ1–42 immunized TG2576 mice Neurobiology of Aging. 21: 152-153. DOI: 10.1016/S0197-4580(00)82023-0  0.519
1999 Benzing WC, Wujek JR, Ward EK, Shaffer D, Ashe KH, Younkin SG, Brunden KR. Evidence for glial-mediated inflammation in aged APP(SW) transgenic mice. Neurobiology of Aging. 20: 581-9. PMID 10674423 DOI: 10.1016/S0197-4580(99)00065-2  0.399
1999 Refolo LM, Eckman C, Prada CM, Yager D, Sambamurti K, Mehta N, Hardy J, Younkin SG. Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells. Journal of Neurochemistry. 73: 2383-8. PMID 10582597 DOI: 10.1046/J.1471-4159.1999.0732383.X  0.402
1999 Sambamurti K, Sevlever D, Koothan T, Refolo LM, Pinnix I, Gandhi S, Onstead L, Younkin L, Prada CM, Yager D, Ohyagi Y, Eckman CB, Rosenberry TL, Younkin SG. Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein. The Journal of Biological Chemistry. 274: 26810-4. PMID 10480887 DOI: 10.1074/Jbc.274.38.26810  0.383
1999 Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, Fischer E, Younkin S, Borchelt DR, Hsiao KK, Carlson GA. SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nature Neuroscience. 2: 157-61. PMID 10195200 DOI: 10.1038/5715  0.387
1998 Grünberg J, Walter J, Eckman C, Capell A, Schindzielorz A, Younkin S, Mehta N, Hardy J, Haass C. Truncated presenilin 2 derived from differentially spliced mRNA does not affect the ratio of amyloid beta-peptide 1-42/1-40. Neuroreport. 9: 3293-9. PMID 9831466 DOI: 10.1097/00001756-199810050-00027  0.373
1998 Younkin SG. The role of A beta 42 in Alzheimer's disease. Journal of Physiology, Paris. 92: 289-92. PMID 9789825 DOI: 10.1016/S0928-4257(98)80035-1  0.431
1998 Citron M, Eckman CB, Diehl TS, Corcoran C, Ostaszewski BL, Xia W, Levesque G, St George Hyslop P, Younkin SG, Selkoe DJ. Additive effects of PS1 and APP mutations on secretion of the 42-residue amyloid beta-protein. Neurobiology of Disease. 5: 107-16. PMID 9746908 DOI: 10.1006/Nbdi.1998.0183  0.325
1998 Clarke NJ, Tomlinson AJ, Ohyagi Y, Younkin S, Naylor S. Detection and quantitation of cellularly derived amyloid beta peptides by immunoprecipitation-HPLC-MS. Febs Letters. 430: 419-23. PMID 9688584 DOI: 10.1016/S0014-5793(98)00706-6  0.322
1998 Davis JA, Naruse S, Chen H, Eckman C, Younkin S, Price DL, Borchelt DR, Sisodia SS, Wong PC. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 20: 603-9. PMID 9539132 DOI: 10.1016/S0896-6273(00)80998-8  0.388
1998 Murai H, Pierce JE, Raghupathi R, Smith DH, Saatman KE, Trojanowski JQ, Lee VM, Loring JF, Eckman C, Younkin S, McIntosh TK. Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury. The Journal of Comparative Neurology. 392: 428-38. PMID 9514508 DOI: 10.1002/(Sici)1096-9861(19980323)392:4<428::Aid-Cne2>3.0.Co;2-2  0.398
1998 Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, ... ... Younkin S, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine. 4: 97-100. PMID 9427614 DOI: 10.1038/Nm0198-097  0.388
1997 Eckman CB, Mehta ND, Crook R, Perez-tur J, Prihar G, Pfeiffer E, Graff-Radford N, Hinder P, Yager D, Zenk B, Refolo LM, Prada CM, Younkin SG, Hutton M, Hardy J. A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43). Human Molecular Genetics. 6: 2087-9. PMID 9328472 DOI: 10.1093/Hmg/6.12.2087  0.36
1997 Carlson GA, Borchelt DR, Dake A, Turner S, Danielson V, Coffin JD, Eckman C, Meiners J, Nilsen SP, Younkin SG, Hsiao KK. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Human Molecular Genetics. 6: 1951-9. PMID 9302276 DOI: 10.1093/Hmg/6.11.1951  0.356
1997 Lamb BT, Call LM, Slunt HH, Bardel KA, Lawler AM, Eckman CB, Younkin SG, Holtz G, Wagner SL, Price DL, Sisodia SS, Gearhart JD. Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice. Human Molecular Genetics. 6: 1535-41. PMID 9285791 DOI: 10.1093/Hmg/6.9.1535  0.394
1997 Zhang F, Eckman C, Younkin S, Hsiao KK, Iadecola C. Increased Susceptibility to Ischemic Brain Damage in Transgenic Mice Overexpressing the Amyloid Precursor Protein The Journal of Neuroscience. 17: 7655-7661. DOI: 10.1523/Jneurosci.17-20-07655.1997  0.318
1997 Harigaya Y, Saido TC, Shoji M, Younkin SG. 813 Quantitative analysis of amyloid B protein with amino-terminal pyroglutamate 3 in alzheimer's disease brains Neuroscience Research. 28: S104. DOI: 10.1016/S0168-0102(97)90275-3  0.443
1996 Ho L, Fukuchi Ki, Younkin SG. The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells. The Journal of Biological Chemistry. 271: 30929-34. PMID 8940079 DOI: 10.1074/Jbc.271.48.30929  0.403
1996 Borchelt DR, Thinakaran G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Seeger M, Levey AI, Gandy SE, ... ... Younkin SG, et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron. 17: 1005-13. PMID 8938131 DOI: 10.1016/S0896-6273(00)80230-5  0.441
1996 Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, ... ... Younkin S, et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383: 710-3. PMID 8878479 DOI: 10.1038/383710A0  0.384
1996 Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice Science. 274: 99-102. PMID 8810256 DOI: 10.1126/Science.274.5284.99  0.384
1996 Kawarabayashi T, Shoji M, Sato M, Sasaki A, Ho L, Eckman CB, Prada CM, Younkin SG, Kobayashi T, Tada N, Matsubara E, Iizuka T, Harigaya Y, Kasai K, Hirai S. Accumulation of beta-amyloid fibrils in pancreas of transgenic mice. Neurobiology of Aging. 17: 215-22. PMID 8744402 DOI: 10.1016/0197-4580(95)02061-6  0.34
1996 Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, ... ... Younkin S, et al. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Medicine. 2: 864-70. PMID 8705854 DOI: 10.1038/Nm0896-864  0.385
1996 Turner RS, Suzuki N, Chyung AS, Younkin SG, Lee VM. Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation. The Journal of Biological Chemistry. 271: 8966-70. PMID 8621541 DOI: 10.1074/Jbc.271.15.8966  0.347
1996 Harigaya Y, Eckman C, Prada C, Saido T, Younkin S. 698 Biochemical analysis of AD brains for amyloid B protein with amino-terminal pyroglutamate Neurobiology of Aging. 17: S173-S174. DOI: 10.1016/S0197-4580(96)80700-7  0.388
1996 Younkin LH, Eckman CB, Yager D, Graff-Rafford N, Younkin SG. 673 Analysis of plasma Aβ concentration in sporadic AD patients and non-demented subjects of all ages Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80675-0  0.343
1996 Kawarabayashi T, Shoji M, Sato M, Sasaki A, Younkin SG, Matsubara E, Iizuka T, Igeta Y, Kanai M, Ishiguro K, Tomidokoro Y, Kobayashi T, Tada N, Okamoto K, Hirai S. 630 Accumulation of ß amyloid in transgenic mice Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80632-4  0.302
1996 Eckman CB, Prada C-, Fauq A, Younkin SG. 271 Pharmacological manipulation of Alzheimer's amyloid β protein in vitro and in vivo Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80273-9  0.383
1996 Younkin S, Scheuner D, Song X, Eckman C, Citron M, Suzuki N, Bird T, Hardy J, Hutton M, Lannfelt L, Levy-Lahad E, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, et al. 149 The Presenilin 1 and 2 mutations linked to familial Alzheimer's Disease increase the extracellular concentration of amyloid 0 protein (Aβ) ending at Aβ42(43) Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80151-5  0.437
1995 Biere AL, Ostaszewski B, Zhao H, Gillespie S, Younkin SG, Selkoe DJ. Co-expression of beta-amyloid precursor protein (betaAPP) and apolipoprotein E in cell culture: analysis of betaAPP processing. Neurobiology of Disease. 2: 177-87. PMID 9174001 DOI: 10.1006/Nbdi.1995.0019  0.465
1995 Shaffer LM, Dority MD, Gupta-Bansal R, Frederickson RC, Younkin SG, Brunden KR. Amyloid beta protein (A beta) removal by neuroglial cells in culture. Neurobiology of Aging. 16: 737-45. PMID 8532106 DOI: 10.1016/0197-4580(95)00055-J  0.338
1995 Gravina SA, Ho L, Eckman CB, Long KE, Otvos L, Younkin LH, Suzuki N, Younkin SG. Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). The Journal of Biological Chemistry. 270: 7013-6. PMID 7706234 DOI: 10.1074/Jbc.270.13.7013  0.329
1995 Younkin SG. Evidence that A beta 42 is the real culprit in Alzheimer's disease. Annals of Neurology. 37: 287-8. PMID 7695227 DOI: 10.1002/Ana.410370303  0.417
1995 Hsiao KK, Borchelt DR, Olson K, Johannsdottir R, Kitt C, Yunis W, Xu S, Eckman C, Younkin S, Price D. Age-related CNS disorder and early death in transgenic FVB/N mice overexpressing Alzheimer amyloid precursor proteins. Neuron. 15: 1203-18. PMID 7576662 DOI: 10.1016/0896-6273(95)90107-8  0.348
1995 Song X, Jensen M, Suzuki N, Lannlelt L, Younkin SG. The ΔNL Alzheimer Mutation (Swedish) Increases Plasma Amyloid B Protein Concentration Journal of Neuropathology and Experimental Neurology. 54: 412. DOI: 10.1097/00005072-199505000-00025  0.332
1994 Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos L, Eckman C, Golde TE, Younkin SG. An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science (New York, N.Y.). 264: 1336-40. PMID 8191290 DOI: 10.1126/Science.8191290  0.52
1994 Nakamura T, Shoji M, Harigaya Y, Watanabe M, Hosoda K, Cheung TT, Shaffer LM, Golde TE, Younkin LH, Younkin SG. Amyloid beta protein levels in cerebrospinal fluid are elevated in early-onset Alzheimer's disease. Annals of Neurology. 36: 903-11. PMID 7998778 DOI: 10.1002/Ana.410360616  0.578
1994 Younkin SG. The amyloid beta protein precursor mutations linked to familial Alzheimer's disease alter processing in a way that fosters amyloid deposition. The Tohoku Journal of Experimental Medicine. 174: 217-23. PMID 7761987 DOI: 10.1620/Tjem.174.217  0.383
1994 Cheung TT, Ghiso J, Shojif M, Cai X, Golde T, Gandy S, Frangione B, Younkin S. Characterization by radiosequencing of the carboxyl-terminal derivatives produced from normal and mutant amyloid β protein precursors Amyloid. 1: 30-38. DOI: 10.3109/13506129409148622  0.569
1993 Cai XD, Golde TE, Younkin SG. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science (New York, N.Y.). 259: 514-6. PMID 8424174 DOI: 10.1126/Science.8424174  0.533
1993 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proceedings of the National Academy of Sciences of the United States of America. 90: 9513-7. PMID 8415732 DOI: 10.1073/Pnas.90.20.9513  0.55
1993 Golde TE, Cai XD, Shoji M, Younkin SG. Production of amyloid beta protein from normal amyloid beta-protein precursor (beta APP) and the mutated beta APPS linked to familial Alzheimer's disease. Annals of the New York Academy of Sciences. 695: 103-8. PMID 8239266 DOI: 10.1111/J.1749-6632.1993.Tb23036.X  0.53
1993 Whitehouse PJ, Landreth G, Younkin S. Molecular biology of Alzheimer's disease. Molecular Genetic Medicine. 3: 95-137. PMID 8220165 DOI: 10.1016/B978-0-12-462003-2.50008-0  0.314
1993 Shaffer LM, Shein DS, Brannaman CA, Gambetti P, Brunden KR, Younkin SG, Cohen ML. PROCESSING OF NEURONALLY-GENERATED ßAPP BY MACROPHAGES AND MICROGLIA Journal of Neuropathology and Experimental Neurology. 52: 296. DOI: 10.1097/00005072-199305000-00144  0.504
1992 Golde TE, Estus S, Younkin LH, Selkoe DJ, Younkin SG. Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. Science (New York, N.Y.). 255: 728-30. PMID 1738847 DOI: 10.1126/Science.1738847  0.504
1992 Gillespie SL, Golde TE, Younkin SG. Secretory processing of the Alzheimer amyloid beta/A4 protein precursor is increased by protein phosphorylation. Biochemical and Biophysical Research Communications. 187: 1285-90. PMID 1417805 DOI: 10.1016/0006-291X(92)90442-N  0.531
1992 Estus S, Golde TE, Younkin SG. Normal processing of the Alzheimer's disease amyloid beta protein precursor generates potentially amyloidogenic carboxyl-terminal derivatives. Annals of the New York Academy of Sciences. 674: 138-48. PMID 1288359 DOI: 10.1111/J.1749-6632.1992.Tb27483.X  0.596
1991 Kalaria RN, Golde TE, Cohen ML, Younkin SG. Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier. Annals of the New York Academy of Sciences. 640: 145-8. PMID 1776732 DOI: 10.1111/J.1749-6632.1991.Tb00206.X  0.711
1991 Younkin SG. Processing of the Alzheimer's disease beta A4 amyloid protein precursor (APP). Brain Pathology (Zurich, Switzerland). 1: 253-62. PMID 1669715 DOI: 10.1111/J.1750-3639.1991.Tb00668.X  0.415
1990 Podlisny MB, Mammen AL, Schlossmacher MG, Palmert MR, Younkin SG, Selkoe DJ. Detection of soluble forms of the beta-amyloid precursor protein in human plasma. Biochemical and Biophysical Research Communications. 167: 1094-101. PMID 2138892 DOI: 10.1016/0006-291X(90)90635-Z  0.648
1990 Palmert MR, Usiak M, Mayeux R, Raskind M, Tourtellotte WW, Younkin SG. Soluble derivatives of the beta amyloid protein precursor in cerebrospinal fluid: alterations in normal aging and in Alzheimer's disease. Neurology. 40: 1028-34. PMID 2113204 DOI: 10.1212/Wnl.40.7.1028  0.661
1990 Golde TE, Estus S, Usiak M, Younkin LH, Younkin SG. Expression of beta amyloid protein precursor mRNAs: recognition of a novel alternatively spliced form and quantitation in Alzheimer's disease using PCR. Neuron. 4: 253-67. PMID 2106330 DOI: 10.1016/0896-6273(90)90100-T  0.54
1990 Schlossmacher M, Podlisny M, Mammen A, Barbour R, Palmert M, Younkin S, Schenk D, Selkoe D. CHARACTERIZATION OF SOLUBLE TRUNCATED FORMS OF THE AMYLOID PRECURSOR PROTEIN FROM HUMAN PLASMA Journal of Neuropathology and Experimental Neurology. 49: 310. DOI: 10.1097/00005072-199005000-00154  0.597
1990 Palmert MR, Cohen ML, Usiak M, Mayeux R, Raskind M, Tourtellotte W, Younkin SG. ANALYSIS OF CEREBROSPINAL FLUID REVEALS THAT SOLUBLE DERIVATIVES OF THE β AMYLOID PROTEIN PRECURSOR ARE ALTERED IN NORMAL AGING AND TO A GREATER EXTENT IN ALZHEIMERʼS DISEASE Journal of Neuropathology and Experimental Neurology. 49: 309. DOI: 10.1097/00005072-199005000-00151  0.718
1990 Golde TE, Palmert MR, Estus S, Usiak M, Siedlak SL, Perry G, Younkin LH, Younkin SG. The β amyloid protein precursor: Analysis of mRNAs in ad and control brains and of soluble derivatives in human cerebrospinal fluid Molecular Biology and Genetics of Alzheimer's Disease: Proceedings of the International Symposium On Dementia: Molecular Biology and Genetics of Alzheimer's Disease. Ics884. 137-147.  0.599
1989 Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. The beta-amyloid protein precursor of Alzheimer disease has soluble derivatives found in human brain and cerebrospinal fluid. Proceedings of the National Academy of Sciences of the United States of America. 86: 6338-42. PMID 2503832 DOI: 10.1073/Pnas.86.16.6338  0.621
1989 Palmert MR, Siedlak SL, Podlisny MB, Greenberg B, Shelton ER, Chan HW, Usiak M, Selkoe DJ, Perry G, Younkin SG. Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein. Biochemical and Biophysical Research Communications. 165: 182-8. PMID 2480122 DOI: 10.1016/0006-291X(89)91052-8  0.639
1989 Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. THE β AMYLOID PROTEIN PRECURSOR OF ALZHEIMERʼS DISEASE HAS SOLUBLE DERIVATIVES FOUND IN HUMAN BRAIN AND CEREBROSPINAL FLUID Journal of Neuropathology and Experimental Neurology. 48: 378. DOI: 10.1097/00005072-198905000-00237  0.63
1989 Selkoe D, Mammen A, Podlisny M, Palmert M, Younkin S, Schenk D. DETECTION OF CIRCULATING FORMS OF THE β-AMYLOID PRECURSOR PROTEIN (BAPP) IN HUMAN PLASMA Journal of Neuropathology and Experimental Neurology. 48: 377. DOI: 10.1097/00005072-198905000-00236  0.583
1989 Golde TE, Younkin SG. CONSTRUCTION OF RETROVIRAL VECTORS DESIGNED TO INCREASE EXPRESSION OF THE β AMYLOID PROTEIN AND ITS PRECURSOR Journal of Neuropathology and Experimental Neurology. 48: 341. DOI: 10.1097/00005072-198905000-00128  0.441
1988 Cohen ML, Golde TE, Usiak MF, Younkin LH, Younkin SG. In situ hybridization of nucleus basalis neurons shows increased beta-amyloid mRNA in Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 85: 1227-31. PMID 3277188 DOI: 10.1073/Pnas.85.4.1227  0.719
1988 Palmert MR, Podlisny MB, Witker DS, Oltersdorf T, Younkin LH, Selkoe DJ, Younkin SG. Antisera to an amino-terminal peptide detect the amyloid protein precursor of Alzheimer's disease and recognize senile plaques. Biochemical and Biophysical Research Communications. 156: 432-7. PMID 3140814 DOI: 10.1016/S0006-291X(88)80859-3  0.632
1988 Palmert MR, Golde TE, Cohen ML, Kovacs DM, Tanzi RE, Gusella JF, Usiak MF, Younkin LH, Younkin SG. Amyloid protein precursor messenger RNAs: differential expression in Alzheimer's disease. Science (New York, N.Y.). 241: 1080-4. PMID 2457949  0.795
1988 PALMERT MR, GOLDE TE, COHEN ML, KOVACS DM, TANZI RE, GUSELLA JF, USIAK MF, YOUNKIN LH, YOUNKIN SG. AMYLOID PROTEIN PRECURSOR mRNA LACKING THE KUNITZ PROTEASE INHIBITOR SEQUENCE INCREASES IN AD NUCLEUS BASALIS AND LOCUS CERULEUS NEURONS Alzheimer Disease & Associated Disorders. 2: 401. DOI: 10.1097/00002093-198802040-00031  0.756
1988 Cohen ML, Golde TE, Usiak MF, Younkin LH, Younkin SG. In situ hybridization of nucleus basalis neurons shows increased β-amyloid mRNA in Alzheimerʼs disease Alzheimer Disease & Associated Disorders. 2: 383. DOI: 10.1097/00002093-198802040-00011  0.583
1987 Cohen M, Golde T, Usiak M, Younkin S. IN SITU HYBRIDIZATION IN HUMAN NUCLEUS BASALIS OF MEYNERT Journal of Neuropathology and Experimental Neurology. 46: 365. DOI: 10.1097/00005072-198705000-00106  0.603
1987 Younkin S, Levin R, Usiak M, Younkin L. Increased Asymmetric Acetylcholinesterase In AlzheimerʼS Disease Is Localized In Neuritic Plaques: 17 Journal of Neuropathology and Experimental Neurology. 46: 337. DOI: 10.1097/00005072-198705000-00024  0.374
1986 Younkin LH, Lockett G, Usiak M, Younkin SG, Roessmann U. MOLECULAR FORMS OF ACETYLCHOLINESTERASE IN ALZHEIMERʼS DISEASE Journal of Neuropathology and Experimental Neurology. 45: 377. DOI: 10.1097/00005072-198605000-00190  0.325
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