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Steven G. Younkin, MD, University of Pennsylvania, PhD, University of Pennsylvania - Related publications

Affiliations: 
Research Mayo Cllinic Jacksonville, Jacksonville, FL, United States 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=35
Website:
http://mayoresearch.mayo.edu/mayo/research/staff/younkin_sg.cfm
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Farkhondeh T, Khan H, Aschner M, Samini F, Pourbagher-Shahri AM, Aramjoo H, Roshanravan B, Hoyte C, Mehrpour O, Samarghandian S. Impact of Cannabis-Based Medicine on Alzheimer's disease by Focusing on the Amyloid β- Modifications: A Systematic Study. Cns & Neurological Disorders Drug Targets. PMID 32640965 DOI: 10.2174/1871527319666200708130745   
2020 Mamun AA, Uddin MS, Bin Bashar MF, Zaman S, Begum Y, Bulbul IJ, Islam MS, Sarwar MS, Mathew B, Amran MS, Md Ashraf G, Bin-Jumah MN, Mousa SA, Abdel-Daim MM. Molecular Insight into the Therapeutic Promise of Targeting for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2020: 5086250. PMID 32509144 DOI: 10.1155/2020/5086250   
2020 Mazinani N, Strilchuk AW, Baylis JR, Hur WS, Jefferies WA, Kastrup CJ. Bleeding is increased in amyloid precursor protein knockout mouse. Research and Practice in Thrombosis and Haemostasis. 4: 823-828. PMID 32685890 DOI: 10.1002/rth2.12375   
2020 Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 32597805 DOI: 10.3233/JAD-200128   
2020 Gericke C, Mallone A, Engelhardt B, Nitsch RM, Ferretti MT. Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in Immunology. 11: 1029. PMID 32582162 DOI: 10.3389/fimmu.2020.01029   
2020 Liu M, Qian T, Zhou W, Tao X, Sang S, Zhao L. Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model. Neuroreport. PMID 32639272 DOI: 10.1097/WNR.0000000000001499   
2020 Taylor X, Cisternas P, You Y, You Y, Xiang S, Marambio Y, Zhang J, Vidal R, Lasagna-Reeves CA. A1 reactive astrocytes and a loss of TREM2 are associated with an early stage of pathology in a mouse model of cerebral amyloid angiopathy. Journal of Neuroinflammation. 17: 223. PMID 32711525 DOI: 10.1186/s12974-020-01900-7   
2020 Ennerfelt HE, Lukens JR. The role of innate immunity in Alzheimer's disease. Immunological Reviews. PMID 32588460 DOI: 10.1111/imr.12896   
2020 Iqbal UH, Zeng E, Pasinetti GM. The Use of Antimicrobial and Antiviral Drugs in Alzheimer's Disease. International Journal of Molecular Sciences. 21. PMID 32664669 DOI: 10.3390/ijms21144920   
2020 Keleman A, Wisch JK, Bollinger RM, Grant EA, Benzinger TL, Morris JC, Ances BM, Stark SL. Falls Associate with Neurodegenerative Changes in ATN Framework of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 32741815 DOI: 10.3233/JAD-200192   
2020 Dahal E, Ghammraoui B, Badano A. Feasibility of a label-free X-ray method to estimate brain amyloid load in small animals. Journal of Neuroscience Methods. 343: 108822. PMID 32574641 DOI: 10.1016/j.jneumeth.2020.108822   
2020 Stefanescu R, Stanciu GD, Luca A, Paduraru L, Tamba BI. Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease. Biomolecules. 10. PMID 32517180 DOI: 10.3390/biom10060870   
2020 Volicer L. Physiological and pathological functions of beta-amyloid in the brain and alzheimer's disease: A review. The Chinese Journal of Physiology. 63: 95-100. PMID 32594062 DOI: 10.4103/CJP.CJP_10_20   
2020 Soheili-Nezhad S, Jahanshad N, Guelfi S, Khosrowabadi R, Saykin AJ, Thompson PM, Beckmann CF, Sprooten E, Zarei M, . Imaging genomics discovery of a new risk variant for Alzheimer's disease in the postsynaptic SHARPIN gene. Human Brain Mapping. PMID 32558014 DOI: 10.1002/hbm.25083   
2020 Vasanthakumar A, Davis JW, Idler K, Waring JF, Asque E, Riley-Gillis B, Grosskurth S, Srivastava G, Kim S, Nho K, Nudelman KNH, Faber K, Sun Y, Foroud TM, Estrada K, ... , et al. Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease. Clinical Epigenetics. 12: 84. PMID 32539856 DOI: 10.1186/s13148-020-00864-y   
2020 Wang J, Sun BL, Xiang Y, Tian DY, Zhu C, Li WW, Liu YH, Bu XL, Shen LL, Jin WS, Wang Z, Zeng GH, Xu W, Chen LY, Chen XW, et al. Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP/PS1 mice. Translational Psychiatry. 10: 230. PMID 32661266 DOI: 10.1038/s41398-020-00918-y   
2020 Cone AS, Hurwitz SN, Lee GS, Yuan X, Zhou Y, Li Y, Meckes DG. Alix and Syntenin-1 direct amyloid precursor protein trafficking into extracellular vesicles. Bmc Molecular and Cell Biology. 21: 58. PMID 32731849 DOI: 10.1186/s12860-020-00302-0   
2020 Wu PF, Bhore N, Lee YL, Chou JY, Chen YW, Wu PY, Hsu WM, Lee H, Huang YS, Lu PJ, Liao YF. Phosphatidylinositol-4-phosphate 5-kinase type 1α attenuates Aβ production by promoting non-amyloidogenic processing of amyloid precursor protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32686865 DOI: 10.1096/fj.202000113R   
2020 Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H. Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease. Current Protein & Peptide Science. PMID 32538723 DOI: 10.2174/1389203721666200615173213   
2020 Sae-Lee W, Scott LL, Brose L, Encarnacion AJ, Shi T, Kore P, Oyibo LO, Ye C, Rozmiarek SK, Pierce JT. APP-induced Patterned Neurodegeneration Exacerbated by in . G3 (Bethesda, Md.). PMID 32580938 DOI: 10.1534/g3.120.401486   
2020 Vemula PK, Jing Y, Cicolini J, Zhang H, Mockett BG, Abraham WC, Liu P. Altered brain arginine metabolism with age in the APP/PSEN1 mouse model of Alzheimer's disease. Neurochemistry International. 104798. PMID 32711019 DOI: 10.1016/j.neuint.2020.104798   
2020 Rafii MS. Alzheimer's Disease in Down Syndrome: Progress in the Design and Conduct of Drug Prevention Trials. Cns Drugs. PMID 32506291 DOI: 10.1007/s40263-020-00740-6   
2020 Chen Y, Fang L, Chen S, Zhou H, Fan Y, Lin L, Li J, Xu J, Chen Y, Ma Y, Chen Y. Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer's Disease. Biomed Research International. 2020: 8456596. PMID 32596386 DOI: 10.1155/2020/8456596   
2020 Harris SS, Wolf F, De Strooper B, Busche MA. Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron. PMID 32579881 DOI: 10.1016/j.neuron.2020.06.005   
2020 Hammes J, Bischof GN, Bohn KP, Onur O, Schneider A, Fliessbach K, Hoenig MC, Jessen F, Neumaier B, Drzezga AE, van Eimeren T. One stop shop: Flortaucipir PET differentiates amyloid positive and negative forms of neurodegenerative diseases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32620704 DOI: 10.2967/jnumed.120.244061   
2020 Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Frontiers in Neuroscience. 14: 705. PMID 32714142 DOI: 10.3389/fnins.2020.00705   
2020 Uddin MS, Kabir MT, Al Mamun A, Behl T, Mansouri RA, Aloqbi AA, Perveen A, Hafeez A, Ashraf GM. Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease. Current Pharmaceutical Design. PMID 32473620 DOI: 10.2174/1381612826666200531151004   
2020 He Y, Zhang H, Wang T, Han Z, Ni QB, Wang K, Wang L, Zhang Y, Hu Y, Jin S, Sun BL, Liu G. Impact of Serum Calcium Levels on Alzheimer's Disease: A Mendelian Randomization Study. Journal of Alzheimer's Disease : Jad. PMID 32538835 DOI: 10.3233/JAD-191249   
2020 Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Ko K, Jung G, Lee HN, Lee JY, Sohn CH, Lee YS, Shin SA, Kim YK, Lee DY, . Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment. Frontiers in Aging Neuroscience. 12: 160. PMID 32581770 DOI: 10.3389/fnagi.2020.00160   
2020 Almeida ZL, Brito RMM. Structure and Aggregation Mechanisms in Amyloids. Molecules (Basel, Switzerland). 25. PMID 32155822 DOI: 10.3390/molecules25051195   
2020 Li D, Zhang J, Li X, Chen Y, Yu F, Liu Q. Insights into lncRNAs in Alzheimer's Disease Mechanisms. Rna Biology. PMID 32605500 DOI: 10.1080/15476286.2020.1788848   
2020 Resende R, Ferreira-Marques M, Moreira P, Coimbra JRM, Baptista SJ, Isidoro C, Salvador JAR, Dinis TCP, Pereira CF, Santos AE. New BACE1 Chimeric Peptide Inhibitors Selectively Prevent AβPPβ Cleavage Decreasing Amyloid-β Production and Accumulation in Alzheimer's Disease Models. Journal of Alzheimer's Disease : Jad. PMID 32597812 DOI: 10.3233/JAD-200381   
2020 Khoury R, Grossberg GT. Deciphering Alzheimer's disease: predicting new therapeutic strategies via improved understanding of biology and pathogenesis. Expert Opinion On Therapeutic Targets. 1-10. PMID 32603232 DOI: 10.1080/14728222.2020.1790530   
2020 Prendecki M, Kowalska M, Łagan-Jędrzejczyk U, Piekut T, Krokos A, Kozubski W, Dorszewska J. Genetic factors related to the immune system in subjects at risk of developing Alzheimer's disease. Journal of Integrative Neuroscience. 19: 359-371. PMID 32706201 DOI: 10.31083/j.jin.2020.02.110   
2020 Golub JS, Sharma RK, Rippon BQ, Brickman AM, Luchsinger JA. The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid. The Laryngoscope. PMID 32644260 DOI: 10.1002/lary.28859   
2020 Jang JW, Kim Y, Kim S, Park SW, Kwon SO, Park YH, Lim JS, Youn YC, Hun Kim S, Kim S, . Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum. Neuroimage. Clinical. 27: 102282. PMID 32590333 DOI: 10.1016/j.nicl.2020.102282   
2020 Teppang KL, Ehrlich RS, Yang J. Method to discriminate amyloids using fluorescent probes. Methods in Enzymology. 639: 91-114. PMID 32475414 DOI: 10.1016/bs.mie.2020.04.010   
2020 Hirschstein Z, Vanga GR, Wang G, Novakovic ZM, Grasso P. MA-[D-Leu-4]-OB3, a small molecule synthetic peptide leptin mimetic, improves episodic memory, and reduces serum levels of tumor necrosis factor-alpha and neurodegeneration in mouse models of Type 1 and Type 2 Diabetes Mellitus. Biochimica Et Biophysica Acta. General Subjects. 129697. PMID 32738275 DOI: 10.1016/j.bbagen.2020.129697   
2020 Kang MS, Aliaga AA, Shin M, Mathotaarachchi S, Benedet AL, Pascoal TA, Therriault J, Chamoun M, Savard M, Devenyi GA, Mathieu A, Chakravarty MM, Sandelius Å, Blennow K, Zetterberg H, ... , et al. Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer's disease. Molecular Psychiatry. PMID 32591633 DOI: 10.1038/s41380-020-0818-1   
2020 Prieto S, Valerio KE, Moody JN, Hayes SM, Hayes JP, . Genetic Risk for Alzheimer's Disease Moderates the Association Between Medial Temporal Lobe Volume and Episodic Memory Performance Among Older Adults. Journal of Alzheimer's Disease : Jad. PMID 32538837 DOI: 10.3233/JAD-191312   
2020 Jia L, Wang W, Yan Y, Hu R, Sang J, Zhao W, Wang Y, Wei W, Cui W, Yang G, Lu F, Zheng J, Liu F. General Aggregation-Induced Emission Probes for Amyloid Inhibitors with Dual Inhibition Capacity against Amyloid β-Protein and α-Synuclein. Acs Applied Materials & Interfaces. PMID 32584021 DOI: 10.1021/acsami.0c07745   
2020 Ferguson AC, Tank R, Lyall LM, Ward J, Celis-Morales C, Strawbridge R, Ho F, Whelan CD, Gill J, Welsh P, Anderson JJ, Mark PB, Mackay DF, Smith DJ, Pell JP, et al. Alzheimer's Disease Susceptibility Gene Apolipoprotein E (APOE) and Blood Biomarkers in UK Biobank (N  =  395,769). Journal of Alzheimer's Disease : Jad. PMID 32651323 DOI: 10.3233/JAD-200338   
2020 Khalaf NEA, El Banna FM, Youssef MY, Mosaad YM, Daba MY, Ashour RH. Clopidogrel combats neuroinflammation and enhances learning behavior and memory in a rat model of Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. 172956. PMID 32474163 DOI: 10.1016/j.pbb.2020.172956   
2020 Kim KH, Seo JD, Kim ES, Kim HS, Jeon S, Pak K, Lee MJ, Lee JH, Lee YM, Lee K, Shin JH, Ko JK, Jung NY, Lee JM, Yoon JA, et al. Comparison of Amyloid in Cerebrospinal Fluid, Brain Imaging, and Autopsy in a Case of Progressive Supranuclear Palsy. Alzheimer Disease and Associated Disorders. PMID 32520735 DOI: 10.1097/WAD.0000000000000396   
2020 Jangampalli Adi Pradeepkiran, Arubala P Reddy, Xiangling Yin, Maria Manczak, P Hemachandra Reddy. Protective effects of BACE1 inhibitory ligand molecules against amyloid beta-induced synaptic and mitochondrial toxicities in Alzheimer’s disease Human Molecular Genetics. 29: 49-69. PMID 31595293 DOI: 10.1093/hmg/ddz227   
2020 Gillet JN. Alzheimer's disease: unraveling APOE4 binding to amyloid-beta peptide and lipids with molecular dynamics and quantum mechanics. Journal of Biomolecular Structure & Dynamics. 1-7. PMID 32580638 DOI: 10.1080/07391102.2020.1784287   
2020 Park J, Kim H, Kim J, Cheon M. A practical application of generative adversarial networks for RNA-seq analysis to predict the molecular progress of Alzheimer's disease. Plos Computational Biology. 16: e1008099. PMID 32706788 DOI: 10.1371/journal.pcbi.1008099   
2020 Gutiérrez-de Pablo V, Gómez C, Poza J, Maturana-Candelas A, Martins S, Gomes I, Lopes AM, Pinto N, Hornero R. Relationship between the Presence of the 4 Allele and EEG Complexity along the Alzheimer's Disease Continuum. Sensors (Basel, Switzerland). 20. PMID 32664228 DOI: 10.3390/s20143849   
2020 Henríquez G, Mendez L, Schmid AN, Guerrero ED, Collins SA, Castañeda E, Narayan M. Testing Amyloid Cross-Toxicity in the Vertebrate Brain. Acs Omega. 5: 15586-15591. PMID 32637834 DOI: 10.1021/acsomega.0c01819   
2020 Francistiová L, Bianchi C, Di Lauro C, Sebastián-Serrano Á, de Diego-García L, Kobolák J, Dinnyés A, Díaz-Hernández M. The Role of P2X7 Receptor in Alzheimer's Disease. Frontiers in Molecular Neuroscience. 13: 94. PMID 32581707 DOI: 10.3389/fnmol.2020.00094