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Neelroop Parikshak, M.D., Ph.D. - Publications

Affiliations: 
2003-2007 Mathematics, Biochemistry Rice University, Houston, TX 
 2007-2017 Neuroscience University of California, Los Angeles, Los Angeles, CA 
 2017-2021 Neurology University of California, San Francisco, San Francisco, CA 
 2021- Genetics, Neuroscience Regeneron, Rensselaer, NY, United States 
Area:
transcriptomics, human genetics, neurological diseases, neuropsychiatric disorders
Website:
http://www.neelroop.com/connect
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Andrews MG, Siebert C, Wang L, White ML, Ross J, Morales R, Donnay M, Bamfonga G, Mukhtar T, McKinney AA, Gemenes K, Wang S, Bi Q, Crouch EE, Parikshak N, et al. LIF signaling regulates outer radial glial to interneuron fate during human cortical development. Cell Stem Cell. PMID 37673072 DOI: 10.1016/j.stem.2023.08.009  0.753
2022 Gandal MJ, Haney JR, Wamsley B, Yap CX, Parhami S, Emani PS, Chang N, Chen GT, Hoftman GD, de Alba D, Ramaswami G, Hartl CL, Bhattacharya A, Luo C, Jin T, ... ... Parikshak NN, et al. Broad transcriptomic dysregulation occurs across the cerebral cortex in ASD. Nature. PMID 36323788 DOI: 10.1038/s41586-022-05377-7  0.79
2022 Andrews MG, Mukhtar T, Eze UC, Simoneau CR, Ross J, Parikshak N, Wang S, Zhou L, Koontz M, Velmeshev D, Siebert CV, Gemenes KM, Tabata T, Perez Y, Wang L, et al. Tropism of SARS-CoV-2 for human cortical astrocytes. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122236119. PMID 35858406 DOI: 10.1073/pnas.2122236119  0.731
2019 Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, Geschwind DH. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap. Focus (American Psychiatric Publishing). 17: 66-72. PMID 32015716 DOI: 10.1176/appi.focus.17103  0.641
2019 Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, Prabhakar S, Geschwind DH, Mill J. Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Human Molecular Genetics. 28: 2201-2211. PMID 31220268 DOI: 10.1093/Hmg/Ddz052  0.591
2019 Haney J, Parhami S, Ramaswami G, Alba D, Hartl C, Ou J, Parikshak N, Swarup V, Gandal M, Geschwind D. 2 Regional Variation In Transcriptional Dysregulation And Patterning In Postmortem Cerebral Cortex In Asd European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2019.07.143  0.694
2019 Wong CCY, Smith RG, Hannon E, Assary E, Parikshak N, Prabhakar S, Geschwind D, Mill J. Convergent Methylomic Signatures Between Autism Associated With Duplications Of Chromosome 15Q And Idiopathic Autism European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.359  0.571
2018 Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, et al. Integrative network analysis reveals biological pathways associated with Williams syndrome. Journal of Child Psychology and Psychiatry, and Allied Disciplines. PMID 30362171 DOI: 10.1111/Jcpp.12999  0.682
2018 Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S, Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, et al. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature. PMID 30111840 DOI: 10.1038/S41586-018-0423-5  0.576
2018 Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, de la Torre Ubieta L, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. PMID 29995847 DOI: 10.1038/S41586-018-0295-8  0.749
2018 Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH. Sex-chromosome dosage effects on gene expression in humans. Proceedings of the National Academy of Sciences of the United States of America. PMID 29946024 DOI: 10.1073/Pnas.1802889115  0.533
2018 Schwede M, Nagpal S, Gandal MJ, Parikshak NN, Mirnics K, Geschwind DH, Morrow EM. Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex. Journal of Neurodevelopmental Disorders. 10: 18. PMID 29859039 DOI: 10.1186/S11689-018-9237-X  0.727
2018 Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science (New York, N.Y.). 359: 693-697. PMID 29439242 DOI: 10.1126/Science.Aad6469  0.724
2016 Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. PMID 27919067 DOI: 10.1038/Nature20612  0.794
2016 Sun W, Poschmann J, Cruz-Herrera Del Rosario R, Parikshak NN, Hajan HS, Kumar V, Ramasamy R, Belgard TG, Elanggovan B, Wong CC, Mill J, Geschwind DH, Prabhakar S. Histone Acetylome-wide Association Study of Autism Spectrum Disorder. Cell. 167: 1385-1397.e11. PMID 27863250 DOI: 10.1016/J.Cell.2016.10.031  0.781
2016 Gandal MJ, Leppa V, Won H, Parikshak NN, Geschwind DH. The road to precision psychiatry: translating genetics into disease mechanisms. Nature Neuroscience. 19: 1397-1407. PMID 27786179 DOI: 10.1038/Nn.4409  0.704
2016 Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. PMID 27760116 DOI: 10.1038/Nature19847  0.788
2016 Wu YE, Parikshak NN, Belgard TG, Geschwind DH. Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. Nature Neuroscience. PMID 27571009 DOI: 10.1038/Nn.4373  0.76
2016 Werling DM, Parikshak NN, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nature Communications. 7: 10717. PMID 26892004 DOI: 10.1038/Ncomms10717  0.773
2015 Lee JA, Damianov A, Lin CH, Fontes M, Parikshak NN, Anderson ES, Geschwind DH, Black DL, Martin KC. Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron. PMID 26687839 DOI: 10.1016/J.Neuron.2015.11.025  0.553
2015 Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, ... ... Parikshak N, et al. The PsychENCODE project. Nature Neuroscience. 18: 1707-1712. PMID 26605881 DOI: 10.1038/Nn.4156  0.786
2015 Suthana NA, Parikshak NN, Ekstrom AD, Ison MJ, Knowlton BJ, Bookheimer SY, Fried I. Specific responses of human hippocampal neurons are associated with better memory. Proceedings of the National Academy of Sciences of the United States of America. 112: 10503-8. PMID 26240357 DOI: 10.1073/Pnas.1423036112  0.473
2015 Parikshak NN, Gandal MJ, Geschwind DH. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders. Nature Reviews. Genetics. 16: 441-58. PMID 26149713 DOI: 10.1038/Nrg3934  0.72
2015 Bakken TE, Miller JA, Luo R, Bernard A, Bennett JL, Lee CK, Bertagnolli D, Parikshak NN, Smith KA, Sunkin SM, Amaral DG, Geschwind DH, Lein ES. Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. Human Molecular Genetics. 24: 4327-39. PMID 25954031 DOI: 10.1093/Hmg/Ddv166  0.744
2014 Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, et al. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 159: 1511-23. PMID 25525873 DOI: 10.1016/J.Cell.2014.11.035  0.523
2014 Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 83: 69-86. PMID 24991955 DOI: 10.1016/J.Neuron.2014.05.035  0.77
2013 Parikshak NN, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell. 155: 1008-21. PMID 24267887 DOI: 10.1016/J.Cell.2013.10.031  0.691
2013 Stein JL, Parikshak NN, Geschwind DH. Rare inherited variation in autism: beginning to see the forest and a few trees. Neuron. 77: 209-11. PMID 23352155 DOI: 10.1016/J.Neuron.2013.01.010  0.631
2013 Parikshak NN, Geschwind DH. Neuroscience and the Genomic Revolution: An Overview Genomic and Personalized Medicine. 2: 1018-1027. DOI: 10.1016/B978-0-12-382227-7.00084-7  0.37
2012 Fogel BL, Wexler E, Wahnich A, Friedrich T, Vijayendran C, Gao F, Parikshak N, Konopka G, Geschwind DH. RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Human Molecular Genetics. 21: 4171-86. PMID 22730494 DOI: 10.1093/Hmg/Dds240  0.788
2012 Sanders SJ, Murtha MT, Gupta AR, Murdoch JD, Raubeson MJ, Willsey AJ, Ercan-Sencicek AG, DiLullo NM, Parikshak NN, Stein JL, Walker MF, Ober GT, Teran NA, Song Y, El-Fishawy P, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 485: 237-41. PMID 22495306 DOI: 10.1038/Nature10945  0.645
2011 Lu PH, Thompson PM, Leow A, Lee GJ, Lee A, Yanovsky I, Parikshak N, Khoo T, Wu S, Geschwind D, Bartzokis G. Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study. Journal of Alzheimer's Disease : Jad. 23: 433-42. PMID 21098974 DOI: 10.3233/Jad-2010-101398  0.534
2010 Raji CA, Ho AJ, Parikshak NN, Becker JT, Lopez OL, Kuller LH, Hua X, Leow AD, Toga AW, Thompson PM. Brain structure and obesity. Human Brain Mapping. 31: 353-64. PMID 19662657 DOI: 10.1002/Hbm.20870  0.378
2009 Leow AD, Yanovsky I, Parikshak N, Hua X, Lee S, Toga AW, Jack CR, Bernstein MA, Britson PJ, Gunter JL, Ward CP, Borowski B, Shaw LM, Trojanowski JQ, Fleisher AS, et al. Alzheimer's disease neuroimaging initiative: a one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition. Neuroimage. 45: 645-55. PMID 19280686 DOI: 10.1016/J.Neuroimage.2009.01.004  0.389
2009 Chou YY, Leporé N, Avedissian C, Madsen SK, Parikshak N, Hua X, Shaw LM, Trojanowski JQ, Weiner MW, Toga AW, Thompson PM. Mapping correlations between ventricular expansion and CSF amyloid and tau biomarkers in 240 subjects with Alzheimer's disease, mild cognitive impairment and elderly controls. Neuroimage. 46: 394-410. PMID 19236926 DOI: 10.1016/J.Neuroimage.2009.02.015  0.368
2009 Aganj I, Sapiro G, Parikshak N, Madsen SK, Thompson PM. Measurement of cortical thickness from MRI by minimum line integrals on soft-classified tissue. Human Brain Mapping. 30: 3188-99. PMID 19219850 DOI: 10.1002/Hbm.20740  0.401
2009 Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human Brain Mapping. 30: 2766-88. PMID 19172649 DOI: 10.1002/Hbm.20708  0.377
2009 Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Toga AW, Jack CR, Schuff N, Weiner MW, Thompson PM. Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Neuroimage. 45: S3-15. PMID 19041724 DOI: 10.1016/J.Neuroimage.2008.10.043  0.394
2009 Morra J, Tu Z, Apostolova L, Green A, Avedissian C, Madsen S, Parikshak N, Toga A, Jack C, Schuff N, Weiner M, Thompson P. Automated Hippocampal Segmentation and Mapping Reveals Genetically Accelerated Tissue Loss in 1-year Repeat MRI data from 490 Alzheimer's Disease, MCI, and Control Subjects Neuroimage. 47. DOI: 10.1016/S1053-8119(09)71153-X  0.336
2009 Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Weiner MW, Thompson PM. Corrigendum to "Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls" [NeuroImage 43 (2008) 59-68] (DOI:10.1016/j.neuroimage.2008.07.003) Neuroimage. 44: 1439. DOI: 10.1016/J.Neuroimage.2008.10.028  0.358
2009 Hua X, Yanovsky I, Leow A, Lee S, Ho A, Parikshak N, Toga A, Jack C, Weiner M, Thompson P. Tensor Based Morphometry as Surrogate Marker for Alzheimer's Disease and Mild Cognitive Impairment: Optimizing Statistical Power Neuroimage. 47: S90. DOI: 10.1016/J.Jalz.2009.05.632  0.347
2008 Hua X, Leow AD, Parikshak N, Lee S, Chiang MC, Toga AW, Jack CR, Weiner MW, Thompson PM. Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: an MRI study of 676 AD, MCI, and normal subjects. Neuroimage. 43: 458-69. PMID 18691658 DOI: 10.1016/J.Neuroimage.2008.07.013  0.412
2008 Morra JH, Tu Z, Apostolova LG, Green AE, Avedissian C, Madsen SK, Parikshak N, Hua X, Toga AW, Jack CR, Weiner MW, Thompson PM. Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls. Neuroimage. 43: 59-68. PMID 18675918 DOI: 10.1016/J.Neuroimage.2008.07.003  0.382
2008 Apostolova LG, Morra JH, Green AH, Hwang K, Avedissian C, Parikshak N, Cummings JL, Toga AW, Jack CR, Weiner MW, Thompson PM. O1-02-05: Automated longitudinal 3D mapping of hippocampal ADAS-cog delayed recall effects in 293 normal elderly, MCI and Alzheimer's disease subjects Alzheimer's & Dementia. 4: T110-T110. DOI: 10.1016/J.Jalz.2008.05.224  0.339
2008 Thompson P, Apostolova LG, Morra JH, Green AE, Hwang K, Avedissian C, Parikshak N, Cummings JL, Toga AW, Jack CR, Weiner MW. IC-P3-223: Automated longitudinal 3D mapping of hippocampal ADASCPG delayed recall effects in 293 normal elderly, MCI and AD subjects Alzheimer's & Dementia. 4: T95-T95. DOI: 10.1016/J.Jalz.2008.05.168  0.367
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