| Year |
Citation |
Score |
| 2023 |
Upadhyay A, Chhangani D, Rao NR, Kofler J, Vassar R, Rincon-Limas DE, Savas JN. Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity. Molecular Neurodegeneration. 18: 61. PMID 37710351 DOI: 10.1186/s13024-023-00654-z |
0.78 |
|
| 2023 |
Cahan JG, Vassar R, Bonakdarpour B. Lower Cerebrospinal Fluid Amyloid-β Predicts Sooner Time to Antipsychotic Use in Alzheimer's Disease. Journal of Alzheimer's Disease Reports. 7: 641-647. PMID 37483323 DOI: 10.3233/ADR-220064 |
0.305 |
|
| 2023 |
Chandra S, Di Meco A, Dodiya HB, Popovic J, Cuddy LK, Weigle IQ, Zhang X, Sadleir K, Sisodia SS, Vassar R. The gut microbiome regulates astrocyte reaction to Aβ amyloidosis through microglial dependent and independent mechanisms. Molecular Neurodegeneration. 18: 45. PMID 37415149 DOI: 10.1186/s13024-023-00635-2 |
0.355 |
|
| 2023 |
Chandra S, Sisodia SS, Vassar RJ. The gut microbiome in Alzheimer's disease: what we know and what remains to be explored. Molecular Neurodegeneration. 18: 9. PMID 36721148 DOI: 10.1186/s13024-023-00595-7 |
0.372 |
|
| 2022 |
Dobrowolska Zakaria JA, Bateman RJ, Lysakowska M, Khatri A, Jean-Gilles D, Kennedy ME, Vassar R. The metabolism of human soluble amyloid precursor protein isoforms is quantifiable by a stable isotope labeling-tandem mass spectrometry method. Scientific Reports. 12: 14985. PMID 36056033 DOI: 10.1038/s41598-022-18869-3 |
0.362 |
|
| 2022 |
Cuddy LK, Alia AO, Salvo MA, Chandra S, Grammatopoulos TN, Justman CJ, Lansbury PT, Mazzulli JR, Vassar R. Farnesyltransferase inhibitor LNK-754 attenuates axonal dystrophy and reduces amyloid pathology in mice. Molecular Neurodegeneration. 17: 54. PMID 35987691 DOI: 10.1186/s13024-022-00561-9 |
0.479 |
|
| 2022 |
Di Meco A, Kemal S, Popovic J, Chandra S, Sadleir KR, Vassar R. Poloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice. Current Alzheimer Research. PMID 35579170 DOI: 10.2174/1567205019666220509143823 |
0.459 |
|
| 2022 |
Upadhyay A, Vassar RJ, Savas JN. Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain. Journal of Visualized Experiments : Jove. PMID 35575522 DOI: 10.3791/63816 |
0.774 |
|
| 2022 |
Sadleir KR, Popovic J, Khatri A, Vassar R. Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis. Plos One. 17: e0263332. PMID 35108319 DOI: 10.1371/journal.pone.0263332 |
0.42 |
|
| 2021 |
McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nature Reviews. Neurology. PMID 34548654 DOI: 10.1038/s41582-021-00545-1 |
0.332 |
|
| 2020 |
Cuddy LK, Prokopenko D, Cunningham EP, Brimberry R, Song P, Kirchner R, Chapman BA, Hofmann O, Hide W, Procissi D, Hanania T, Leiser SC, Tanzi RE, Vassar R. Aβ-accelerated neurodegeneration caused by Alzheimer's-associated variant R1279Q is rescued by angiotensin system inhibition in mice. Science Translational Medicine. 12. PMID 32998969 DOI: 10.1126/scitranslmed.aaz2541 |
0.438 |
|
| 2020 |
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Vassar R, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2 |
0.461 |
|
| 2020 |
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, et al. The β-Secretase BACE1 in Alzheimer's Disease. Biological Psychiatry. PMID 32223911 DOI: 10.1016/J.Biopsych.2020.02.001 |
0.557 |
|
| 2020 |
Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y |
0.551 |
|
| 2020 |
Vassar R. Editorial: Implications for BACE1 Inhibitor Clinical Trials: Adult Conditional BACE1 Knockout Mice Exhibit Axonal Organization Defects in the Hippocampus. The Journal of Prevention of Alzheimer's Disease. 6: 78-84. PMID 30756113 DOI: 10.14283/jpad.2019.3 |
0.362 |
|
| 2019 |
Kemal S, Vassar R. Death by microglia. The Journal of Experimental Medicine. PMID 31645368 DOI: 10.1084/jem.20191536 |
0.345 |
|
| 2019 |
Lazic D, Sagare AP, Nikolakopoulou AM, Griffin JH, Vassar R, Zlokovic BV. 3K3A-activated protein C blocks amyloidogenic BACE1 pathway and improves functional outcome in mice. The Journal of Experimental Medicine. PMID 30647119 DOI: 10.1084/Jem.20181035 |
0.501 |
|
| 2018 |
Sadleir KR, Popovic J, Vassar R. ER stress is not elevated in the 5XFAD mouse model of Alzheimer's disease. The Journal of Biological Chemistry. PMID 30315100 DOI: 10.1074/jbc.RA118.005769 |
0.482 |
|
| 2018 |
Ou-Yang MH, Kurz JE, Nomura T, Popovic J, Rajapaksha TW, Dong H, Contractor A, Chetkovich DM, Tourtellotte WG, Vassar R. Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice. Science Translational Medicine. 10. PMID 30232227 DOI: 10.1126/Scitranslmed.Aao5620 |
0.526 |
|
| 2018 |
Kukreja L, Shahidehpour R, Kim G, Keegan J, Sadleir KR, Russell T, Csernansky J, Mesulam M, Vassar RJ, Wang L, Dong H, Geula C. Differential Neurotoxicity Related to Tetracycline Transactivator and TDP-43 Expression in Conditional TDP-43 Mouse Model of Frontotemporal Lobar Degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29807909 DOI: 10.1523/Jneurosci.1836-17.2018 |
0.592 |
|
| 2018 |
Stern AL, Ghura S, Gannon PJ, Akay-Espinoza C, Phan JM, Yee AC, Vassar R, Gelman BB, Kolson DL, Jordan-Sciutto KL. BACE1 mediates HIV-associated and excitotoxic neuronal damage through an APP-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29632166 DOI: 10.1523/Jneurosci.1280-17.2018 |
0.426 |
|
| 2017 |
Vassar R. Seeds of Destruction: New Mechanistic Insights into the Role of Apolipoprotein E4 in Alzheimer's Disease. Neuron. 96: 953-955. PMID 29216455 DOI: 10.1016/j.neuron.2017.11.022 |
0.336 |
|
| 2017 |
Rocchi A, Yamamoto S, Ting T, Fan Y, Sadleir K, Wang Y, Zhang W, Huang S, Levine B, Vassar R, He C. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. Plos Genetics. 13: e1006962. PMID 28806762 DOI: 10.1371/Journal.Pgen.1006962 |
0.512 |
|
| 2017 |
Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. APP mouse models for Alzheimer's disease preclinical studies. The Embo Journal. PMID 28768718 DOI: 10.15252/Embj.201797397 |
0.512 |
|
| 2017 |
Liu P, Reichl JH, Rao ER, McNellis BM, Huang ES, Hemmy LS, Forster CL, Kuskowski MA, Borchelt DR, Vassar R, Ashe KH, Zahs KR. Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice. Journal of Alzheimer's Disease : Jad. PMID 28059792 DOI: 10.3233/Jad-161027 |
0.516 |
|
| 2017 |
Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, et al. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. The American Journal of Pathology. 187: 91-109. PMID 27993242 DOI: 10.1016/J.Ajpath.2016.09.006 |
0.424 |
|
| 2016 |
Vassar R. BACE1 inhibition as a therapeutic strategy for Alzheimer's disease. Journal of Sport and Health Science. 5: 388-390. PMID 30356583 DOI: 10.1016/j.jshs.2016.10.004 |
0.387 |
|
| 2016 |
Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, He C. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 0. PMID 27791467 DOI: 10.1080/15548627.2016.1240855 |
0.304 |
|
| 2016 |
Iram T, Trudler D, Kain D, Kanner S, Galron R, Vassar R, Barzilai A, Blinder P, Fishelson Z, Frenkel D. Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection. Neurobiology of Disease. PMID 27544484 DOI: 10.1016/J.Nbd.2016.08.001 |
0.492 |
|
| 2016 |
Yan R, Fan Q, Zhou J, Vassar R. Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease. Neuroscience and Biobehavioral Reviews. PMID 27044452 DOI: 10.1016/J.Neubiorev.2016.03.025 |
0.484 |
|
| 2016 |
Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, Vassar R. Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathologica. PMID 26993139 DOI: 10.1007/S00401-016-1558-9 |
0.575 |
|
| 2016 |
Vassar RJ. Dystrophic neurites are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation: the potential role of Aβ oligomers Neurobiology of Aging. 39: S25. DOI: 10.1016/j.neurobiolaging.2016.01.110 |
0.362 |
|
| 2015 |
Liao F, Zhang TJ, Jiang H, Lefton KB, Robinson GO, Vassar R, Sullivan PM, Holtzman DM. Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models. Acta Neuropathologica Communications. 3: 70. PMID 26556230 DOI: 10.1186/S40478-015-0250-Y |
0.487 |
|
| 2015 |
Fernandes HB, Riordan S, Nomura T, Remmers CL, Kraniotis S, Marshall JJ, Kukreja L, Vassar R, Contractor A. Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6544-53. PMID 25904804 DOI: 10.1523/Jneurosci.0314-14.2015 |
0.679 |
|
| 2015 |
Sadleir KR, Eimer WA, Cole SL, Vassar R. Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level. Molecular Neurodegeneration. 10: 1. PMID 25567526 DOI: 10.1186/1750-1326-10-1 |
0.8 |
|
| 2015 |
Farfara D, Tuby H, Trudler D, Doron-Mandel E, Maltz L, Vassar RJ, Frenkel D, Oron U. Low-level laser therapy ameliorates disease progression in a mouse model of Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 55: 430-6. PMID 24994540 DOI: 10.1007/s12031-014-0354-z |
0.392 |
|
| 2014 |
Vassar R. BACE1 inhibitor drugs in clinical trials for Alzheimer's disease. Alzheimer's Research & Therapy. 6: 89. PMID 25621019 DOI: 10.1186/s13195-014-0089-7 |
0.449 |
|
| 2014 |
Vassar R, Zheng H. Molecular neurodegeneration: basic biology and disease pathways. Molecular Neurodegeneration. 9: 34. PMID 25248568 DOI: 10.1186/1750-1326-9-34 |
0.322 |
|
| 2014 |
Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. Plos One. 9: e101643. PMID 24992504 DOI: 10.1371/Journal.Pone.0101643 |
0.815 |
|
| 2014 |
Kandalepas PC, Vassar R. The normal and pathologic roles of the Alzheimer's β-secretase, BACE1. Current Alzheimer Research. 11: 441-9. PMID 24893886 DOI: 10.2174/1567205011666140604122059 |
0.506 |
|
| 2014 |
Kukreja L, Kujoth GC, Prolla TA, Van Leuven F, Vassar R. Increased mtDNA mutations with aging promotes amyloid accumulation and brain atrophy in the APP/Ld transgenic mouse model of Alzheimer's disease. Molecular Neurodegeneration. 9: 16. PMID 24885175 DOI: 10.1186/1750-1326-9-16 |
0.674 |
|
| 2014 |
Vassar R, Kuhn PH, Haass C, Kennedy ME, Rajendran L, Wong PC, Lichtenthaler SF. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. Journal of Neurochemistry. 130: 4-28. PMID 24646365 DOI: 10.1111/Jnc.12715 |
0.494 |
|
| 2014 |
Yan R, Vassar R. Targeting the β secretase BACE1 for Alzheimer's disease therapy. The Lancet. Neurology. 13: 319-29. PMID 24556009 DOI: 10.1016/S1474-4422(13)70276-X |
0.425 |
|
| 2014 |
Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, Thinakaran G. Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Molecular Neurodegeneration. 9: 1. PMID 24386896 DOI: 10.1186/1750-1326-9-1 |
0.699 |
|
| 2013 |
Maarouf CL, Kokjohn TA, Whiteside CM, Macias MP, Kalback WM, Sabbagh MN, Beach TG, Vassar R, Roher AE. Molecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis. Biochemistry Insights. 6: 1-10. PMID 25210460 DOI: 10.4137/BCI.S13025 |
0.309 |
|
| 2013 |
Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, ... ... Vassar R, et al. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Reports. 5: 1552-63. PMID 24373286 DOI: 10.1016/J.Celrep.2013.12.006 |
0.448 |
|
| 2013 |
Vassar R. ADAM10 prodomain mutations cause late-onset Alzheimer's disease: not just the latest FAD. Neuron. 80: 250-3. PMID 24139026 DOI: 10.1016/j.neuron.2013.09.031 |
0.42 |
|
| 2013 |
Sadleir KR, Bennett DA, Schneider JA, Vassar R. Elevated Aβ42 in aged, non-demented individuals with cerebral atherosclerosis. Current Alzheimer Research. 10: 785-9. PMID 23919773 DOI: 10.2174/15672050113109990152 |
0.423 |
|
| 2013 |
Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques. Acta Neuropathologica. 126: 329-52. PMID 23820808 DOI: 10.1007/S00401-013-1152-3 |
0.818 |
|
| 2013 |
Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, et al. Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models. The American Journal of Pathology. 183: 369-81. PMID 23747948 DOI: 10.1016/J.Ajpath.2013.05.005 |
0.378 |
|
| 2013 |
Veeraraghavalu K, Zhang C, Miller S, Hefendehl JK, Rajapaksha TW, Ulrich J, Jucker M, Holtzman DM, Tanzi RE, Vassar R, Sisodia SS. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-f. PMID 23704555 DOI: 10.1126/Science.1235505 |
0.48 |
|
| 2013 |
Eimer WA, Vassar R. Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Aβ42 accumulation and Caspase-3 activation. Molecular Neurodegeneration. 8: 2. PMID 23316765 DOI: 10.1186/1750-1326-8-2 |
0.787 |
|
| 2013 |
Avrahami L, Farfara D, Shaham-Kol M, Vassar R, Frenkel D, Eldar-Finkelman H. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. The Journal of Biological Chemistry. 288: 1295-306. PMID 23155049 DOI: 10.1074/jbc.M112.409250 |
0.459 |
|
| 2013 |
Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Udayar V, Elie A, Lefkow M, Roseman J, Meckler X, Bhattacharyya S, George M, Waters J, Bindokas VP, Parent AT, Rajendran L, ... ... Vassar R, et al. Regulation of dynamic BACE1 trafficking in neurons Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O8 |
0.701 |
|
| 2013 |
Vassar R. BACE1, the Alzheimer’s beta-secretase enzyme, in health and disease Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-s1-o7 |
0.562 |
|
| 2013 |
Kandalepas PC, Sadleir KR, Eimer WA, Zhao J, Nicholson DA, Vassar R. Erratum to: The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques Acta Neuropathologica. 126: 623-623. DOI: 10.1007/S00401-013-1176-8 |
0.765 |
|
| 2012 |
Perez SE, Nadeem M, Sadleir KR, Matras J, Kelley CM, Counts SE, Vassar R, Mufson EJ. Dimebon alters hippocampal amyloid pathology in 3xTg-AD mice. International Journal of Physiology, Pathophysiology and Pharmacology. 4: 115-27. PMID 23071869 |
0.436 |
|
| 2012 |
Hitt B, Riordan SM, Kukreja L, Eimer WA, Rajapaksha TW, Vassar R. β-Site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1)-deficient mice exhibit a close homolog of L1 (CHL1) loss-of-function phenotype involving axon guidance defects. The Journal of Biological Chemistry. 287: 38408-25. PMID 22988240 DOI: 10.1074/Jbc.M112.415505 |
0.755 |
|
| 2012 |
Sadleir KR, Vassar R. Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease. The Journal of Biological Chemistry. 287: 7224-35. PMID 22223639 DOI: 10.1074/jbc.M111.333914 |
0.508 |
|
| 2012 |
Kandalepas PC, Vassar R. Identification and biology of β-secretase. Journal of Neurochemistry. 120: 55-61. PMID 22122287 DOI: 10.1111/j.1471-4159.2011.07512.x |
0.551 |
|
| 2011 |
Rajapaksha TW, Eimer WA, Bozza TC, Vassar R. The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb. Molecular Neurodegeneration. 6: 88. PMID 22204380 DOI: 10.1186/1750-1326-6-88 |
0.789 |
|
| 2011 |
Zhao J, O'Connor T, Vassar R. The contribution of activated astrocytes to Aβ production: implications for Alzheimer's disease pathogenesis. Journal of Neuroinflammation. 8: 150. PMID 22047170 DOI: 10.1186/1742-2094-8-150 |
0.453 |
|
| 2011 |
Vassar R, Kandalepas PC. The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease. Alzheimer's Research & Therapy. 3: 20. PMID 21639952 DOI: 10.1186/alzrt82 |
0.516 |
|
| 2011 |
Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S, Vassar R, Segal D, Gazit E, Frenkel D, Ovadia M. Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. Plos One. 6: e16564. PMID 21305046 DOI: 10.1371/Journal.Pone.0016564 |
0.491 |
|
| 2011 |
Youmans KL, Leung S, Zhang J, Maus E, Baysac K, Bu G, Vassar R, Yu C, LaDu MJ. Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. Journal of Neuroscience Methods. 196: 51-9. PMID 21219931 DOI: 10.1016/J.Jneumeth.2010.12.025 |
0.455 |
|
| 2011 |
Kaczorowski CC, Sametsky E, Shah S, Vassar R, Disterhoft JF. Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease. Neurobiology of Aging. 32: 1452-65. PMID 19833411 DOI: 10.1016/J.Neurobiolaging.2009.09.003 |
0.711 |
|
| 2010 |
Hitt BD, Jaramillo TC, Chetkovich DM, Vassar R. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization. Molecular Neurodegeneration. 5: 31. PMID 20731874 DOI: 10.1186/1750-1326-5-31 |
0.79 |
|
| 2010 |
De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews. Neurology. 6: 99-107. PMID 20139999 DOI: 10.1038/nrneurol.2009.218 |
0.487 |
|
| 2010 |
Hong HS, Maezawa I, Budamagunta M, Rana S, Shi A, Vassar R, Liu R, Lam KS, Cheng RH, Hua DH, Voss JC, Jin LW. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiology of Aging. 31: 1690-9. PMID 19022536 DOI: 10.1016/J.Neurobiolaging.2008.09.019 |
0.431 |
|
| 2009 |
Vassar R, Kovacs DM, Yan R, Wong PC. The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12787-94. PMID 19828790 DOI: 10.1523/Jneurosci.3657-09.2009 |
0.519 |
|
| 2009 |
Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Seidah NG, Vassar R, Wong PC, Fukata M, Kounnas MZ, Thinakaran G. Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. The Journal of Biological Chemistry. 284: 3793-803. PMID 19074428 DOI: 10.1074/Jbc.M808920200 |
0.452 |
|
| 2009 |
Cole SL, Vassar R. Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1. Neurobiology of Aging. 30: 1535-44. PMID 18289733 DOI: 10.1016/j.neurobiolaging.2007.12.012 |
0.487 |
|
| 2008 |
O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, ... Vassar R, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/J.Neuron.2008.10.047 |
0.785 |
|
| 2008 |
Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T. X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain. The Journal of Biological Chemistry. 283: 35763-71. PMID 18845544 DOI: 10.1074/Jbc.M801353200 |
0.466 |
|
| 2008 |
Cole SL, Vassar R. The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology. The Journal of Biological Chemistry. 283: 29621-5. PMID 18650431 DOI: 10.1074/jbc.R800015200 |
0.557 |
|
| 2008 |
Cole SL, Vassar R. BACE1 structure and function in health and Alzheimer's disease. Current Alzheimer Research. 5: 100-20. PMID 18393796 DOI: 10.2174/156720508783954758 |
0.552 |
|
| 2008 |
Vassar R. S3-03-01: BACE1 levels are elevated in a rapid amyloid pathology transgenic mouse model of Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.385 |
0.471 |
|
| 2007 |
Cole SL, Vassar R. The Basic Biology of BACE1: A Key Therapeutic Target for Alzheimer's Disease. Current Genomics. 8: 509-30. PMID 19415126 DOI: 10.2174/138920207783769512 |
0.536 |
|
| 2007 |
Cole SL, Vassar R. The Alzheimer's disease beta-secretase enzyme, BACE1. Molecular Neurodegeneration. 2: 22. PMID 18005427 DOI: 10.1186/1750-1326-2-22 |
0.526 |
|
| 2007 |
Vassar R. Caspase-3 cleavage of GGA3 stabilizes BACE: implications for Alzheimer's disease. Neuron. 54: 671-3. PMID 17553417 DOI: 10.1016/j.neuron.2007.05.018 |
0.497 |
|
| 2007 |
Ma H, Lesné S, Kotilinek L, Steidl-Nichols JV, Sherman M, Younkin L, Younkin S, Forster C, Sergeant N, Delacourte A, Vassar R, Citron M, Kofuji P, Boland LM, Ashe KH. Involvement of beta-site APP cleaving enzyme 1 (BACE1) in amyloid precursor protein-mediated enhancement of memory and activity-dependent synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 104: 8167-72. PMID 17470798 DOI: 10.1073/Pnas.0609521104 |
0.466 |
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| 2007 |
Zhao J, Fu Y, Yasvoina M, Shao P, Hitt B, O'Connor T, Logan S, Maus E, Citron M, Berry R, Binder L, Vassar R. Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3639-49. PMID 17409228 DOI: 10.1523/Jneurosci.4396-06.2007 |
0.832 |
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| 2007 |
Ohno M, Cole SL, Yasvoina M, Zhao J, Citron M, Berry R, Disterhoft JF, Vassar R. BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice. Neurobiology of Disease. 26: 134-45. PMID 17258906 DOI: 10.1016/J.Nbd.2006.12.008 |
0.564 |
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| 2006 |
Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R. Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10129-40. PMID 17021169 DOI: 10.1523/JNEUROSCI.1202-06.2006 |
0.576 |
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| 2006 |
Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. The European Journal of Neuroscience. 23: 251-60. PMID 16420434 DOI: 10.1111/j.1460-9568.2005.04551.x |
0.506 |
|
| 2006 |
Cole SL, Vassar R. Isoprenoids and Alzheimer's disease: a complex relationship. Neurobiology of Disease. 22: 209-22. PMID 16406223 DOI: 10.1016/j.nbd.2005.11.007 |
0.458 |
|
| 2006 |
Vassar R, Oakley H, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R. O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer's disease mutations Alzheimer's & Dementia. 2: S88-S88. DOI: 10.1016/j.jalz.2006.05.339 |
0.494 |
|
| 2006 |
Vassar R, Velliquette RA, O’Connor T. P4-047: Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: Possible early events in Alzheimer’s disease pathogenesis Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.1785 |
0.434 |
|
| 2005 |
Velliquette RA, O'Connor T, Vassar R. Energy inhibition elevates beta-secretase levels and activity and is potentially amyloidogenic in APP transgenic mice: possible early events in Alzheimer's disease pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10874-83. PMID 16306400 DOI: 10.1523/JNEUROSCI.2350-05.2005 |
0.532 |
|
| 2005 |
Kelly BL, Vassar R, Ferreira A. Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. The Journal of Biological Chemistry. 280: 31746-53. PMID 16002400 DOI: 10.1074/Jbc.M503259200 |
0.516 |
|
| 2005 |
Cole SL, Grudzien A, Manhart IO, Kelly BL, Oakley H, Vassar R. Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism. The Journal of Biological Chemistry. 280: 18755-70. PMID 15718241 DOI: 10.1074/Jbc.M413895200 |
0.412 |
|
| 2005 |
Vassar R. beta-Secretase, APP and Abeta in Alzheimer's disease. Sub-Cellular Biochemistry. 38: 79-103. PMID 15709474 |
0.443 |
|
| 2004 |
Vassar R. BACE1: the beta-secretase enzyme in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 23: 105-14. PMID 15126696 DOI: 10.1385/JMN:23:1-2:105 |
0.53 |
|
| 2004 |
Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. BACE1 deficiency rescues memory deficits and cholinergic dysfunction in a mouse model of Alzheimer's disease. Neuron. 41: 27-33. PMID 14715132 DOI: 10.1016/S0896-6273(03)00810-9 |
0.559 |
|
| 2004 |
Ohno M, Sametsky EA, Younkin LH, Oakley H, Younkin SG, Citron M, Vassar R, Disterhoft JF. P2-037 Genetic evidence for therapeutic inhibition of BACE1 in an Alzheimer's mouse model Neurobiology of Aging. 25: S234. DOI: 10.1016/S0197-4580(04)80784-X |
0.368 |
|
| 2003 |
Luo Y, Bolon B, Damore MA, Fitzpatrick D, Liu H, Zhang J, Yan Q, Vassar R, Citron M. BACE1 (beta-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time. Neurobiology of Disease. 14: 81-8. PMID 13678669 DOI: 10.1016/S0969-9961(03)00104-9 |
0.519 |
|
| 2003 |
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7504-9. PMID 12930788 |
0.435 |
|
| 2003 |
Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G. Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease The Journal of Neuroscience. 23: 7504-7509. DOI: 10.1523/Jneurosci.23-20-07504.2003 |
0.521 |
|
| 2002 |
Vassar R. Beta-secretase (BACE) as a drug target for Alzheimer's disease. Advanced Drug Delivery Reviews. 54: 1589-602. PMID 12453676 DOI: 10.1016/S0169-409X(02)00157-6 |
0.529 |
|
| 2002 |
Estus S, Borchelt D, Kindy MS, Vassar R. Abeta deposition is essential to AD neuropathology. Journal of Alzheimer's Disease : Jad. 4: 133-8. PMID 12226531 DOI: 10.3233/Jad-2002-4302 |
0.451 |
|
| 2001 |
Vassar R. The beta-secretase, BACE: a prime drug target for Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 17: 157-70. PMID 11816789 DOI: 10.1385/JMN:17:2:157 |
0.531 |
|
| 2001 |
Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, Fan W, Kha H, Zhang J, Gong Y, Martin L, Louis JC, Yan Q, Richards WG, Citron M, ... Vassar R, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nature Neuroscience. 4: 231-2. PMID 11224535 DOI: 10.1038/85059 |
0.476 |
|
| 2000 |
Vassar R, Citron M. Abeta-generating enzymes: recent advances in beta- and gamma-secretase research. Neuron. 27: 419-22. PMID 11055423 DOI: 10.1016/S0896-6273(00)00051-9 |
0.358 |
|
| 2000 |
Bennett BD, Denis P, Haniu M, Teplow DB, Kahn S, Louis JC, Citron M, Vassar R. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase. The Journal of Biological Chemistry. 275: 37712-7. PMID 10956649 DOI: 10.1074/Jbc.M005339200 |
0.436 |
|
| 2000 |
Haniu M, Denis P, Young Y, Mendiaz EA, Fuller J, Hui JO, Bennett BD, Kahn S, Ross S, Burgess T, Katta V, Rogers G, Vassar R, Citron M. Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties. The Journal of Biological Chemistry. 275: 21099-106. PMID 10887202 DOI: 10.1074/jbc.M002095200 |
0.417 |
|
| 2000 |
Bennett BD, Babu-Khan S, Loeloff R, Louis JC, Curran E, Citron M, Vassar R. Expression analysis of BACE2 in brain and peripheral tissues. The Journal of Biological Chemistry. 275: 20647-51. PMID 10749877 DOI: 10.1074/jbc.M002688200 |
0.367 |
|
| 2000 |
Haniu M, Denis P, Young Y, Mendiaz B, Bennett BD, Rogers G, Vassar R, Citron M. Characterization of Alzheimer's β-secretase protein bace: A pepsin family member with unusual properties Neurobiology of Aging. 21: 278. DOI: 10.1016/S0197-4580(00)83200-5 |
0.334 |
|
| 1999 |
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, et al. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science (New York, N.Y.). 286: 735-41. PMID 10531052 DOI: 10.1126/Science.286.5440.735 |
0.436 |
|
| 1998 |
Ross SL, Martin F, Simonet L, Jacobsen F, Deshpande R, Vassar R, Bennett B, Luo Y, Wooden S, Hu S, Citron M, Burgess TL. Amyloid precursor protein processing in sterol regulatory element-binding protein site 2 protease-deficient Chinese hamster ovary cells. The Journal of Biological Chemistry. 273: 15309-12. PMID 9624107 DOI: 10.1074/jbc.273.25.15309 |
0.493 |
|
| 1996 |
Mombaerts P, Wang F, Dulac C, Vassar R, Chao SK, Nemes A, Mendelsohn M, Edmondson J, Axel R. The molecular biology of olfactory perception. Cold Spring Harbor Symposia On Quantitative Biology. 61: 135-45. PMID 9246442 DOI: 10.1101/Sqb.1996.061.01.016 |
0.736 |
|
| 1995 |
Fülle HJ, Vassar R, Foster DC, Yang RB, Axel R, Garbers DL. A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proceedings of the National Academy of Sciences of the United States of America. 92: 3571-5. PMID 7724600 DOI: 10.1073/Pnas.92.8.3571 |
0.561 |
|
| 1994 |
Vassar R, Chao SK, Sitcheran R, Nuñez JM, Vosshall LB, Axel R. Topographic organization of sensory projections to the olfactory bulb. Cell. 79: 981-91. PMID 8001145 DOI: 10.1016/0092-8674(94)90029-9 |
0.7 |
|
| 1993 |
Vassar R, Ngai J, Axel R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell. 74: 309-18. PMID 8343958 DOI: 10.1016/0092-8674(93)90422-M |
0.658 |
|
| 1991 |
Coulombe PA, Hutton ME, Vassar R, Fuchs E. A function for keratins and a common thread among different types of epidermolysis bullosa simplex diseases. The Journal of Cell Biology. 115: 1661-74. PMID 1721910 DOI: 10.1083/Jcb.115.6.1661 |
0.35 |
|
| 1991 |
Vassar R, Coulombe PA, Degenstein L, Albers K, Fuchs E. Mutant keratin expression in transgenic mice causes marked abnormalities resembling a human genetic skin disease. Cell. 64: 365-80. PMID 1703046 DOI: 10.1016/0092-8674(91)90645-F |
0.347 |
|
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