Lee J. Martin, PhD - Publications

Affiliations: 
Pathology Johns Hopkins University, Baltimore, MD 
Area:
Neuronal cell death
Website:
http://www.alzresearch.org/team.cfm?ID=19

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Martin LJ, Wong M, Hanaford A. Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes. Frontiers in Neurology. 10: 635. PMID 31275228 DOI: 10.3389/fneur.2019.00635  0.64
2019 O'Brien CE, Santos PT, Kulikowicz E, Reyes M, Koehler RC, Martin LJ, Lee JK. Hypoxia-Ischemia and Hypothermia Independently and Interactively Affect Neuronal Pathology in Neonatal Piglets with Short-Term Recovery. Developmental Neuroscience. 1-17. PMID 31108487 DOI: 10.1159/000496602  1
2019 Singh R, Kulikowicz E, Santos PT, Koehler RC, Martin LJ, Lee JK. Spatial T-maze identifies cognitive deficits in piglets 1 month after hypoxia-ischemia in a model of hippocampal pyramidal neuron loss and interneuron attrition. Behavioural Brain Research. 111921. PMID 31009645 DOI: 10.1016/j.bbr.2019.111921  1
2019 Fang J, Chavez-Valdez R, Flock DL, Avaritt O, Saraswati M, Robertson C, Martin LJ, Northington FJ. An Inhibitor of the Mitochondrial Permeability Transition Pore Lacks Therapeutic Efficacy Following Neonatal Hypoxia Ischemia in Mice. Neuroscience. PMID 30849447 DOI: 10.1016/j.neuroscience.2019.02.030  1
2018 Kageyama Y, Saito A, Pletnikova O, Rudow GL, Irie Y, An Y, Murakami K, Irie K, Resnick SM, Fowler DR, Martin LJ, Troncoso JC. Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques. Scientific Reports. 8: 16895. PMID 30442978 DOI: 10.1038/s41598-018-35004-3  0.44
2018 Santos PT, O'Brien CE, Chen MW, Hopkins CD, Adams S, Kulikowicz E, Singh R, Koehler RC, Martin LJ, Lee JK. Proteasome Biology Is Compromised in White Matter After Asphyxic Cardiac Arrest in Neonatal Piglets. Journal of the American Heart Association. 7: e009415. PMID 30371275 DOI: 10.1161/JAHA.118.009415  1
2018 Koehler RC, Yang ZJ, Lee JK, Martin LJ. Perinatal hypoxic-ischemic brain injury in large animal models: Relevance to human neonatal encephalopathy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18797328. PMID 30149778 DOI: 10.1177/0271678X18797328  1
2018 Martin LJ, Chang Q. DNA Damage Response and Repair, DNA Methylation, and Cell Death in Human Neurons and Experimental Animal Neurons Are Different. Journal of Neuropathology and Experimental Neurology. PMID 29788379 DOI: 10.1093/jnen/nly040  0.36
2018 Chavez-Valdez R, Emerson P, Goffigan-Holmes J, Kirkwood A, Martin LJ, Northington FJ. Delayed injury of hippocampal interneurons after neonatal hypoxia-ischemia and therapeutic hypothermia in a murine model. Hippocampus. PMID 29781223 DOI: 10.1002/hipo.22965  1
2018 Wu D, Martin LJ, Northington FJ, Zhang J. Oscillating-gradient diffusion magnetic resonance imaging detects acute subcellular structural changes in the mouse forebrain after neonatal hypoxia-ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18759859. PMID 29436246 DOI: 10.1177/0271678X18759859  1
2016 LaClair KD, Donde A, Ling JP, Jeong YH, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathologica. PMID 27785573 DOI: 10.1007/s00401-016-1637-y  0.96
2016 Lee JK, Wang B, Reyes M, Armstrong JS, Kulikowicz E, Santos PT, Lee JH, Koehler RC, Martin LJ. Hypothermia and Rewarming Activate a Macroglial Unfolded Protein Response Independent of Hypoxic-Ischemic Brain Injury in Neonatal Piglets. Developmental Neuroscience. PMID 27622292 DOI: 10.1159/000448585  1
2016 Fayzullina S, Martin LJ. DNA Damage Response and DNA Repair in Skeletal Myocytes From a Mouse Model of Spinal Muscular Atrophy. Journal of Neuropathology and Experimental Neurology. PMID 27452406 DOI: 10.1093/jnen/nlw064  1
2016 Martin LJ, Wong M. Enforced DNA Repair Enzymes Rescue Neurons from Apoptosis Induced by Target Deprivation and Axotomy in Mouse Models of Neurodegeneration. Mechanisms of Ageing and Development. PMID 27364693 DOI: 10.1016/j.mad.2016.06.011  0.64
2016 Chang Q, Martin LJ. Voltage-gated calcium channels are abnormal in cultured spinal motoneurons in the G93A-SOD1 transgenic mouse model of ALS. Neurobiology of Disease. PMID 27151771 DOI: 10.1016/j.nbd.2016.04.009  0.36
2015 Wang B, Armstrong JS, Reyes M, Kulikowicz E, Lee JH, Spicer D, Bhalala U, Yang ZJ, Koehler RC, Martin LJ, Lee JK. White matter apoptosis is increased by delayed hypothermia and rewarming in a neonatal piglet model of hypoxic ischemic encephalopathy. Neuroscience. PMID 26739327 DOI: 10.1016/j.neuroscience.2015.12.046  1
2015 Chavez-Valdez R, Flock DL, Martin LJ, Northington FJ. Endoplasmic Reticulum pathology and stress response in neurons precede programmed necrosis after neonatal hypoxia-ischemia. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. PMID 26643212 DOI: 10.1016/j.ijdevneu.2015.11.007  1
2015 Sorge RE, Mapplebeck JC, Rosen S, Beggs S, Taves S, Alexander JK, Martin LJ, Austin JS, Sotocinal SG, Chen D, Yang M, Shi XQ, Huang H, Pillon NJ, Bilan PJ, et al. Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nature Neuroscience. PMID 26120961 DOI: 10.1038/nn.4053  1
2015 Wieskopf JS, Mathur J, Limapichat W, Post MR, Al-Qazzaz M, Sorge RE, Martin LJ, Zaykin DV, Smith SB, Freitas K, Austin JS, Dai F, Zhang J, Marcovitz J, Tuttle AH, et al. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Science Translational Medicine. 7: 287ra72. PMID 25972004 DOI: 10.1126/scitranslmed.3009986  1
2015 Burnsed JC, Chavez-Valdez R, Hossain MS, Kesavan K, Martin LJ, Zhang J, Northington FJ. Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain--a longitudinal study. Plos One. 10: e0118889. PMID 25774892 DOI: 10.1371/journal.pone.0118889  1
2015 Zhu J, Wang B, Lee JH, Armstrong JS, Kulikowicz E, Bhalala US, Martin LJ, Koehler RC, Yang ZJ. Additive Neuroprotection of a 20-HETE Inhibitor with Delayed Therapeutic Hypothermia after Hypoxia-Ischemia in Neonatal Piglets. Developmental Neuroscience. PMID 25721266 DOI: 10.1159/000369007  1
2015 Wang B, Armstrong JS, Lee JH, Bhalala U, Kulikowicz E, Zhang H, Reyes M, Moy N, Spicer D, Zhu J, Yang ZJ, Koehler RC, Martin LJ, Lee JK. Rewarming from therapeutic hypothermia induces cortical neuron apoptosis in a swine model of neonatal hypoxic-ischemic encephalopathy. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 781-93. PMID 25564240 DOI: 10.1038/jcbfm.2014.245  1
2015 Tekes A, Poretti A, Scheurkogel MM, Huisman TA, Howlett JA, Alqahtani E, Lee JH, Parkinson C, Shapiro K, Chung SE, Jennings JM, Gilmore MM, Hogue CW, Martin LJ, Koehler RC, et al. Apparent diffusion coefficient scalars correlate with near-infrared spectroscopy markers of cerebrovascular autoregulation in neonates cooled for perinatal hypoxic-ischemic injury. Ajnr. American Journal of Neuroradiology. 36: 188-93. PMID 25169927 DOI: 10.3174/ajnr.A4083  1
2015 Burnsed JC, Chavez-Valdez R, Hossain MS, Kesavan K, Martin LJ, Zhang J. Correction: Hypoxia-ischemia and therapeutic hypothermia in the neonatal mouse brain - A longitudinal study Plos One. 10. DOI: 10.1371/journal.pone.0129406  1
2014 Martin LJ, Fancelli D, Wong M, Niedzwiecki M, Ballarini M, Plyte S, Chang Q. GNX-4728, a novel small molecule drug inhibitor of mitochondrial permeability transition, is therapeutic in a mouse model of amyotrophic lateral sclerosis. Frontiers in Cellular Neuroscience. 8: 433. PMID 25565966 DOI: 10.3389/fncel.2014.00433  1
2014 Fayzullina S, Martin LJ. Detection and analysis of DNA damage in mouse skeletal muscle in situ using the TUNEL method. Journal of Visualized Experiments : Jove. PMID 25549099 DOI: 10.3791/52211  1
2014 Martin LJ, Cork LC. The non-human primate striatum undergoes marked prolonged remodeling during postnatal development. Frontiers in Cellular Neuroscience. 8: 294. PMID 25294985 DOI: 10.3389/fncel.2014.00294  1
2014 Wu D, Martin LJ, Northington FJ, Zhang J. Oscillating gradient diffusion MRI reveals unique microstructural information in normal and hypoxia-ischemia injured mouse brains. Magnetic Resonance in Medicine. 72: 1366-74. PMID 25168861 DOI: 10.1002/mrm.25441  1
2014 Mahairaki V, Ryu J, Peters A, Chang Q, Li T, Park TS, Burridge PW, Talbot CC, Asnaghi L, Martin LJ, Zambidis ET, Koliatsos VE. Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties. Stem Cells and Development. 23: 2996-3010. PMID 25027006 DOI: 10.1089/scd.2013.0511  1
2014 Fayzullina S, Martin LJ. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). Plos One. 9: e93329. PMID 24667816 DOI: 10.1371/journal.pone.0093329  1
2014 Chavez-Valdez R, Martin LJ, Razdan S, Gauda EB, Northington FJ. Sexual dimorphism in BDNF signaling after neonatal hypoxia-ischemia and treatment with necrostatin-1. Neuroscience. 260: 106-19. PMID 24361177 DOI: 10.1016/j.neuroscience.2013.12.023  1
2014 Martin LJ, Semenkow S, Hanaford A, Wong M. Mitochondrial permeability transition pore regulates Parkinson's disease development in mutant α-synuclein transgenic mice. Neurobiology of Aging. 35: 1132-52. PMID 24325796 DOI: 10.1016/j.neurobiolaging.2013.11.008  1
2014 Aggarwal M, Burnsed J, Martin LJ, Northington FJ, Zhang J. Imaging neurodegeneration in the mouse hippocampus after neonatal hypoxia-ischemia using oscillating gradient diffusion MRI. Magnetic Resonance in Medicine. 72: 829-40. PMID 24123409 DOI: 10.1002/mrm.24956  1
2013 Wong M, Gertz B, Chestnut BA, Martin LJ. Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS. Frontiers in Cellular Neuroscience. 7: 279. PMID 24399935 DOI: 10.3389/fncel.2013.00279  1
2013 Martin LJ, Katzenelson A, Koehler RC, Chang Q. The olfactory bulb in newborn piglet is a reservoir of neural stem and progenitor cells. Plos One. 8: e81105. PMID 24278384 DOI: 10.1371/journal.pone.0081105  1
2013 Martin LJ, Wong M. Aberrant regulation of DNA methylation in amyotrophic lateral sclerosis: a new target of disease mechanisms. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 722-33. PMID 23900692 DOI: 10.1007/s13311-013-0205-6  1
2013 Yang ZJ, Wang B, Kwansa H, Heitmiller KD, Hong G, Carter EL, Jamrogowicz JL, Larson AC, Martin LJ, Koehler RC. Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1612-20. PMID 23860373 DOI: 10.1038/jcbfm.2013.117  1
2013 Creeley C, Dikranian K, Dissen G, Martin L, Olney J, Brambrink A. Propofol-induced apoptosis of neurones and oligodendrocytes in fetal and neonatal rhesus macaque brain British Journal of Anaesthesia. 110: i29-i38. PMID 23722059 DOI: 10.1093/bja/aet173  1
2012 Ni X, Yang ZJ, Wang B, Carter EL, Larson AC, Martin LJ, Koehler RC. Early antioxidant treatment and delayed hypothermia after hypoxia-ischemia have no additive neuroprotection in newborn pigs. Anesthesia and Analgesia. 115: 627-37. PMID 22745113 DOI: 10.1213/ANE.0b013e31825d3600  1
2012 Chavez-Valdez R, Martin LJ, Northington FJ. Programmed Necrosis: A Prominent Mechanism of Cell Death following Neonatal Brain Injury. Neurology Research International. 2012: 257563. PMID 22666585 DOI: 10.1155/2012/257563  1
2012 Chavez-Valdez R, Martin LJ, Flock DL, Northington FJ. Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia. Neuroscience. 219: 192-203. PMID 22579794 DOI: 10.1016/j.neuroscience.2012.05.002  1
2012 Martin LJ. Biology of mitochondria in neurodegenerative diseases. Progress in Molecular Biology and Translational Science. 107: 355-415. PMID 22482456 DOI: 10.1016/B978-0-12-385883-2.00005-9  1
2012 Yang ZJ, Carter EL, Kibler KK, Kwansa H, Crafa DA, Martin LJ, Roman RJ, Harder DR, Koehler RC. Attenuation of neonatal ischemic brain damage using a 20-HETE synthesis inhibitor. Journal of Neurochemistry. 121: 168-79. PMID 22251169 DOI: 10.1111/j.1471-4159.2012.07666.x  1
2012 Gertz B, Wong M, Martin LJ. Nuclear localization of human SOD1 and mutant SOD1-specific disruption of survival motor neuron protein complex in transgenic amyotrophic lateral sclerosis mice. Journal of Neuropathology and Experimental Neurology. 71: 162-77. PMID 22249462 DOI: 10.1097/NEN.0b013e318244b635  1
2012 Martin LJ, Chang Q. Inhibitory synaptic regulation of motoneurons: a new target of disease mechanisms in amyotrophic lateral sclerosis. Molecular Neurobiology. 45: 30-42. PMID 22072396 DOI: 10.1007/s12035-011-8217-x  1
2012 Wong PC, Chiang PM, Martin LJ, Koliatsos V, Price DL. Motor Neuron Diseases Basic Neurochemistry. 801-814. DOI: 10.1016/B978-0-12-374947-5.00045-6  1
2011 Chestnut BA, Chang Q, Price A, Lesuisse C, Wong M, Martin LJ. Epigenetic regulation of motor neuron cell death through DNA methylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16619-36. PMID 22090490 DOI: 10.1523/JNEUROSCI.1639-11.2011  1
2011 Martin LJ. Mitochondrial pathobiology in ALS. Journal of Bioenergetics and Biomembranes. 43: 569-79. PMID 22083126 DOI: 10.1007/s10863-011-9395-y  1
2011 Wang Y, Pan Y, Price A, Martin LJ. Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis. Molecular Neurodegeneration. 6: 75. PMID 22047141 DOI: 10.1186/1750-1326-6-75  1
2011 Ni X, Yang ZJ, Carter EL, Martin LJ, Koehler RC. Striatal neuroprotection from neonatal hypoxia-ischemia in piglets by antioxidant treatment with EUK-134 or edaravone. Developmental Neuroscience. 33: 299-311. PMID 21701140 DOI: 10.1159/000327243  1
2011 Chang Q, Martin LJ. Motoneuron subtypes show specificity in glycine receptor channel abnormalities in a transgenic mouse model of amyotrophic lateral sclerosis. Channels (Austin, Tex.). 5: 299-303. PMID 21558795 DOI: 10.4161/chan.5.4.16206  1
2011 Yang ZJ, Ni X, Carter EL, Kibler K, Martin LJ, Koehler RC. Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum. Neurobiology of Disease. 43: 446-54. PMID 21558004 DOI: 10.1016/j.nbd.2011.04.018  1
2011 Northington FJ, Chavez-Valdez R, Martin LJ. Neuronal cell death in neonatal hypoxia-ischemia. Annals of Neurology. 69: 743-58. PMID 21520238 DOI: 10.1002/ana.22419  1
2011 Chang Q, Martin LJ. Glycine receptor channels in spinal motoneurons are abnormal in a transgenic mouse model of amyotrophic lateral sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 2815-27. PMID 21414903 DOI: 10.1523/JNEUROSCI.2475-10.2011  1
2011 Martin LJ. An approach to experimental synaptic pathology using green fluorescent protein-transgenic mice and gene knockout mice to show mitochondrial permeability transition pore-driven excitotoxicity in interneurons and motoneurons. Toxicologic Pathology. 39: 220-33. PMID 21378209 DOI: 10.1177/0192623310389475  1
2011 Martin LJ, Adams NA, Pan Y, Price A, Wong M. The mitochondrial permeability transition pore regulates nitric oxide-mediated apoptosis of neurons induced by target deprivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 359-70. PMID 21209222 DOI: 10.1523/JNEUROSCI.2225-10.2011  1
2011 Northington FJ, Chavez-Valdez R, Graham EM, Razdan S, Gauda EB, Martin LJ. Necrostatin decreases oxidative damage, inflammation, and injury after neonatal HI. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 178-89. PMID 20571523 DOI: 10.1038/jcbfm.2010.72  1
2010 Martin LJ. Olesoxime, a cholesterol-like neuroprotectant for the potential treatment of amyotrophic lateral sclerosis. Idrugs : the Investigational Drugs Journal. 13: 568-80. PMID 20721828  1
2010 Martin LJ. Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis. Journal of Alzheimer's Disease : Jad. 20: S335-56. PMID 20413846 DOI: 10.3233/JAD-2010-100348  1
2010 Wong M, Martin LJ. Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Human Molecular Genetics. 19: 2284-302. PMID 20223753 DOI: 10.1093/hmg/ddq106  1
2010 Smith WW, Liu Z, Liang Y, Masuda N, Swing DA, Jenkins NA, Copeland NG, Troncoso JC, Pletnikov M, Dawson TM, Martin LJ, Moran TH, Lee MK, Borchelt DR, Ross CA. Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model. Human Molecular Genetics. 19: 2087-98. PMID 20185556 DOI: 10.1093/hmg/ddq086  1
2010 Chen K, Northington FJ, Martin LJ. Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice. Brain Structure & Function. 214: 219-34. PMID 19888600 DOI: 10.1007/s00429-009-0226-4  1
2010 Yang ZJ, Carter EL, Torbey MT, Martin LJ, Koehler RC. Sigma receptor ligand 4-phenyl-1-(4-phenylbutyl)-piperidine modulates neuronal nitric oxide synthase/postsynaptic density-95 coupling mechanisms and protects against neonatal ischemic degeneration of striatal neurons. Experimental Neurology. 221: 166-74. PMID 19883643 DOI: 10.1016/j.expneurol.2009.10.019  1
2010 Martin LJ. The mitochondrial permeability transition pore: a molecular target for amyotrophic lateral sclerosis therapy. Biochimica Et Biophysica Acta. 1802: 186-97. PMID 19651206 DOI: 10.1016/j.bbadis.2009.07.009  1
2009 O'Brien RJ, Resnick SM, Zonderman AB, Ferrucci L, Crain BJ, Pletnikova O, Rudow G, Iacono D, Riudavets MA, Driscoll I, Price DL, Martin LJ, Troncoso JC. Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). Journal of Alzheimer's Disease : Jad. 18: 665-75. PMID 19661626 DOI: 10.3233/JAD-2009-1179  1
2009 Martin LJ, Gertz B, Pan Y, Price AC, Molkentin JD, Chang Q. The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice. Experimental Neurology. 218: 333-46. PMID 19272377 DOI: 10.1016/j.expneurol.2009.02.015  1
2009 Chang Q, Martin LJ. Glycinergic innervation of motoneurons is deficient in amyotrophic lateral sclerosis mice: a quantitative confocal analysis. The American Journal of Pathology. 174: 574-85. PMID 19116365 DOI: 10.2353/ajpath.2009.080557  1
2009 Martin LJ, Liu Z, Pipino J, Chestnut B, Landek MA. Molecular regulation of DNA damage-induced apoptosis in neurons of cerebral cortex. Cerebral Cortex (New York, N.Y. : 1991). 19: 1273-93. PMID 18820287 DOI: 10.1093/cercor/bhn167  1
2009 Martin LJ. Mechanisms of neurodegeneration and therapeutics in animal models of neonatal hypoxic–ischemic encephalopathy Fetal and Neonatal Brain Injury, Fourth Edition. 14-37. DOI: 10.1017/CBO9780511581281.004  1
2008 Stone BS, Zhang J, Mack DW, Mori S, Martin LJ, Northington FJ. Delayed neural network degeneration after neonatal hypoxia-ischemia. Annals of Neurology. 64: 535-46. PMID 19067347 DOI: 10.1002/ana.21517  1
2008 Martin LJ. DNA damage and repair: relevance to mechanisms of neurodegeneration. Journal of Neuropathology and Experimental Neurology. 67: 377-87. PMID 18431258 DOI: 10.1097/NEN.0b013e31816ff780  1
2008 Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1997-2005. PMID 18305234 DOI: 10.1523/JNEUROSCI.4231-07.2008  1
2008 Mueller-Burke D, Koehler RC, Martin LJ. Rapid NMDA receptor phosphorylation and oxidative stress precede striatal neurodegeneration after hypoxic ischemia in newborn piglets and are attenuated with hypothermia. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 26: 67-76. PMID 17950559 DOI: 10.1016/j.ijdevneu.2007.08.015  1
2007 Martin LJ, Liu Z. Adult olfactory bulb neural precursor cell grafts provide temporary protection from motor neuron degeneration, improve motor function, and extend survival in amyotrophic lateral sclerosis mice. Journal of Neuropathology and Experimental Neurology. 66: 1002-18. PMID 17984682 DOI: 10.1097/nen.0b013e318158822b  1
2007 Northington FJ, Zelaya ME, O'Riordan DP, Blomgren K, Flock DL, Hagberg H, Ferriero DM, Martin LJ. Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as "continuum" phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain. Neuroscience. 149: 822-33. PMID 17961929 DOI: 10.1016/j.neuroscience.2007.06.060  1
2007 Riudavets MA, Iacono D, Resnick SM, O'Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC. Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. Neurobiology of Aging. 28: 1484-92. PMID 17599696 DOI: 10.1016/j.neurobiolaging.2007.05.005  1
2007 Martin LJ. Transgenic mice with human mutant genes causing Parkinson's disease and amyotrophic lateral sclerosis provide common insight into mechanisms of motor neuron selective vulnerability to degeneration. Reviews in the Neurosciences. 18: 115-36. PMID 17593875  1
2007 Yang ZJ, Torbey M, Li X, Bernardy J, Golden WC, Martin LJ, Koehler RC. Dopamine receptor modulation of hypoxic-ischemic neuronal injury in striatum of newborn piglets. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1339-51. PMID 17213860 DOI: 10.1038/sj.jcbfm.9600440  1
2007 Martin LJ, Liu Z, Chen K, Price AC, Pan Y, Swaby JA, Golden WC. Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death. The Journal of Comparative Neurology. 500: 20-46. PMID 17099894 DOI: 10.1002/cne.21160  1
2006 Martin LJ. Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis. Journal of Neuropathology and Experimental Neurology. 65: 1103-10. PMID 17146283 DOI: 10.1097/01.jnen.0000248541.05552.c4  1
2006 Lai C, Xie C, McCormack SG, Chiang HC, Michalak MK, Lin X, Chandran J, Shim H, Shimoji M, Cookson MR, Huganir RL, Rothstein JD, Price DL, Wong PC, Martin LJ, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11798-806. PMID 17093100 DOI: 10.1523/JNEUROSCI.2084-06.2006  1
2006 Liu Z, Martin LJ. The adult neural stem and progenitor cell niche is altered in amyotrophic lateral sclerosis mouse brain. The Journal of Comparative Neurology. 497: 468-88. PMID 16736475 DOI: 10.1002/cne.21012  1
2006 Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK. Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 41-50. PMID 16399671 DOI: 10.1523/JNEUROSCI.4308-05.2006  1
2006 Golden WC, Martin LJ. Low-dose ouabain protects against excitotoxic apoptosis and up-regulates nuclear Bcl-2 in vivo. Neuroscience. 137: 133-44. PMID 16297565 DOI: 10.1016/j.neuroscience.2005.10.004  1
2006 Ginsberg SD, Hemby SE, Mufson EJ, Martin LJ. Cell and tissue microdissection in combination with genomic and proteomic applications Neuroanatomical Tract-Tracing 3: Molecules, Neurons, and Systems. 109-141. DOI: 10.1007/0-387-28942-9_4  1
2005 Mueller D, Shamblott MJ, Fox HE, Gearhart JD, Martin LJ. Transplanted human embryonic germ cell-derived neural stem cells replace neurons and oligodendrocytes in the forebrain of neonatal mice with excitotoxic brain damage. Journal of Neuroscience Research. 82: 592-608. PMID 16247803 DOI: 10.1002/jnr.20673  1
2005 Northington FJ, Graham EM, Martin LJ. Apoptosis in perinatal hypoxic-ischemic brain injury: how important is it and should it be inhibited? Brain Research. Brain Research Reviews. 50: 244-57. PMID 16216332 DOI: 10.1016/j.brainresrev.2005.07.003  1
2005 Greene M, Schill K, Takahashi S, Bateman-House A, Beauchamp T, Bok H, Cheney D, Coyle J, Deacon T, Dennett D, Donovan P, Flanagan O, Goldman S, Greely H, Martin L, et al. Ethics: Moral issues of human-non-human primate neural grafting. Science (New York, N.Y.). 309: 385-6. PMID 16020716 DOI: 10.1126/science.1112207  1
2005 Martin LJ, Chen K, Liu Z. Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6449-59. PMID 16000635 DOI: 10.1523/JNEUROSCI.0911-05.2005  1
2005 Rebel A, Koehler RC, Martin LJ. In situ immunoradiographic method for quantification of specific proteins in normal and ischemic brain regions. Journal of Neuroscience Methods. 143: 227-35. PMID 15814155 DOI: 10.1016/j.jneumeth.2004.11.003  1
2005 Tanigami H, Rebel A, Martin LJ, Chen TY, Brusilow SW, Traystman RJ, Koehler RC. Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats. Neuroscience. 131: 437-49. PMID 15708485 DOI: 10.1016/j.neuroscience.2004.10.045  1
2005 Martin LJ, Liu Z, Troncoso J, Price DL. Neuronal cell death in human neurodegenerative diseases and their animal/cell models Apoptosis in Health and Disease: Clinical and Therapeutic Aspects. 96-155. DOI: 10.1017/CBO9780511663543.005  1
2004 Liu Z, Martin LJ. Pluripotent fates and tissue regenerative potential of adult olfactory bulb neural stem and progenitor cells. Journal of Neurotrauma. 21: 1479-99. PMID 15672637 DOI: 10.1089/neu.2004.21.1479  1
2004 Graham EM, Sheldon RA, Flock DL, Ferriero DM, Martin LJ, O'Riordan DP, Northington FJ. Neonatal mice lacking functional Fas death receptors are resistant to hypoxic-ischemic brain injury. Neurobiology of Disease. 17: 89-98. PMID 15350969 DOI: 10.1016/j.nbd.2004.05.007  1
2004 Kofler J, Hattori K, Sawada M, DeVries AC, Martin LJ, Hurn PD, Traystman RJ. Histopathological and behavioral characterization of a novel model of cardiac arrest and cardiopulmonary resuscitation in mice. Journal of Neuroscience Methods. 136: 33-44. PMID 15126043 DOI: 10.1016/j.jneumeth.2003.12.024  1
2004 Martin LJ, Liu Z. Opportunities for neuroprotection in ALS using cell death mechanism rationales Drug Discovery Today: Disease Models. 1: 135-143. DOI: 10.1016/j.ddmod.2004.09.004  1
2003 Golden WC, Brambrink AM, Traystman RJ, Shaffner DH, Martin LJ. Nitration of the striatal Na,K-ATPase alpha3 isoform occurs in normal brain development but is not increased during hypoxia-ischemia in newborn piglets. Neurochemical Research. 28: 1883-9. PMID 14649731 DOI: 10.1023/A:1026132110850  1
2003 Agnew DM, Koehler RC, Guerguerian AM, Shaffner DH, Traystman RJ, Martin LJ, Ichord RN. Hypothermia for 24 hours after asphyxic cardiac arrest in piglets provides striatal neuroprotection that is sustained 10 days after rewarming. Pediatric Research. 54: 253-62. PMID 12736390 DOI: 10.1203/01.PDR.0000072783.22373.FF  1
2003 Liu Z, Martin LJ. Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human. The Journal of Comparative Neurology. 459: 368-91. PMID 12687705 DOI: 10.1002/cne.10664  1
2003 Martin LJ, Price AC, McClendon KB, Al-Abdulla NA, Subramaniam JR, Wong PC, Liu Z. Early events of target deprivation/axotomy-induced neuronal apoptosis in vivo: oxidative stress, DNA damage, p53 phosphorylation and subcellular redistribution of death proteins. Journal of Neurochemistry. 85: 234-47. PMID 12641745  1
2002 Martin LJ, Liu Z. DNA damage profiling in motor neurons: a single-cell analysis by comet assay. Neurochemical Research. 27: 1093-104. PMID 12462407 DOI: 10.1023/A:1020961006216  1
2002 Al-Abdulla NA, Martin LJ. Projection neurons and interneurons in the lateral geniculate nucleus undergo distinct forms of degeneration ranging from retrograde and transsynaptic apoptosis to transient atrophy after cortical ablation in rat Neuroscience. 115: 7-14. PMID 12401317 DOI: 10.1016/S0306-4522(02)00363-9  1
2002 Shaikh AY, Martin LJ. DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis. Neuromolecular Medicine. 2: 47-60. PMID 12230304 DOI: 10.1007/s12017-002-0038-7  1
2002 Lok J, Martin LJ. Rapid subcellular redistribution of Bax precedes caspase-3 and endonuclease activation during excitotoxic neuronal apoptosis in rat brain. Journal of Neurotrauma. 19: 815-28. PMID 12184852 DOI: 10.1089/08977150260190410  1
2002 Lesuisse C, Martin LJ. Immature and mature cortical neurons engage different apoptotic mechanisms involving caspase-3 and the mitogen-activated protein kinase pathway. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 935-50. PMID 12172379 DOI: 10.1097/00004647-200208000-00005  1
2002 Guerguerian AM, Brambrink AM, Traystman RJ, Huganir RL, Martin LJ. Altered expression and phosphorylation of N-methyl-D-aspartate receptors in piglet striatum after hypoxia-ischemia. Brain Research. Molecular Brain Research. 104: 66-80. PMID 12117552 DOI: 10.1016/S0169-328X(02)00285-1  1
2002 Natale JE, Cheng Y, Martin LJ. Thalamic neuron apoptosis emerges rapidly after cortical damage in immature mice Neuroscience. 112: 665-676. PMID 12074908 DOI: 10.1016/S0306-4522(02)00098-2  1
2002 Lesuisse C, Martin LJ. Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death. Journal of Neurobiology. 51: 9-23. PMID 11920724 DOI: 10.1002/neu.10037  1
2002 Ginsberg SD, Martin LJ. Axonal transection in adult rat brain induces transsynaptic apoptosis and persistent atrophy of target neurons. Journal of Neurotrauma. 19: 99-109. PMID 11852982 DOI: 10.1089/089771502753460277  1
2002 Martin LJ, Liu Z. Injury-induced spinal motor neuron apoptosis is preceded by DNA single-strand breaks and is p53- and Bax-dependent. Journal of Neurobiology. 50: 181-97. PMID 11810634 DOI: 10.1002/neu.10026  1
2001 Northington FJ, Ferriero DM, Martin LJ. Neurodegeneration in the thalamus following neonatal hypoxia-ischemia is programmed cell death. Developmental Neuroscience. 23: 186-91. PMID 11598318 DOI: 10.1159/000046141  1
2001 Gabrielson KL, Hogue BA, Bohr VA, Cardounel AJ, Nakajima W, Kofler J, Zweier JL, Rodriguez ER, Martin LJ, de Souza-Pinto NC, Bressler J. Mitochondrial toxin 3-nitropropionic acid induces cardiac and neurotoxicity differentially in mice. The American Journal of Pathology. 159: 1507-20. PMID 11583977 DOI: 10.1016/S0002-9440(10)62536-9  1
2001 Liu Z, Martin LJ. Isolation of mature spinal motor neurons and single-cell analysis using the comet assay of early low-level DNA damage induced in vitro and in vivo Journal of Histochemistry and Cytochemistry. 49: 957-972. PMID 11457924  1
2001 Northington FJ, Ferriero DM, Graham EM, Traystman RJ, Martin LJ. Early Neurodegeneration after Hypoxia-Ischemia in Neonatal Rat Is Necrosis while Delayed Neuronal Death Is Apoptosis. Neurobiology of Disease. 8: 207-19. PMID 11300718 DOI: 10.1006/nbdi.2000.0371  1
1999 Ginsberg SD, Portera-Cailliau C, Martin LJ. Fimbria-fornix transection and excitotoxicity produce similar neurodegeneration in the septum. Neuroscience. 88: 1059-71. PMID 10336121 DOI: 10.1016/S0306-4522(98)00288-7  1
1998 Wong PC, Borchelt DR, Lee MK, Pardo CA, Thinakaran G, Martin LJ, Sisodia SS, Price DL. Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models. Advances in Experimental Medicine and Biology. 446: 145-59. PMID 10079842  1
1998 Mouton PR, Martin LJ, Calhoun ME, Dal Forno G, Price DL. Cognitive decline strongly correlates with cortical atrophy in Alzheimer's dementia. Neurobiology of Aging. 19: 371-7. PMID 9880038 DOI: 10.1016/S0197-4580(98)00080-3  1
1998 Al-Abdulla NA, Portera-Cailliau C, Martin LJ. Occipital cortex ablation in adult rat causes retrograde neuronal death in the lateral geniculate nucleus that resembles apoptosis. Neuroscience. 86: 191-209. PMID 9692754 DOI: 10.1016/S0306-4522(98)00014-1  1
1998 Martin LJ, Al-Abdulla NA, Brambrink AM, Kirsch JR, Sieber FE, Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischemia, and target deprivation: A perspective on the contributions of apoptosis and necrosis. Brain Research Bulletin. 46: 281-309. PMID 9671259 DOI: 10.1016/S0361-9230(98)00024-0  1
1997 Price DL, Wong PC, Borchelt DR, Pardo CA, Thinakaran G, Doan AP, Lee MK, Martin LJ, Sisodia SS. Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems. Revue Neurologique. 153: 484-95. PMID 9683997  1
1997 Martin LJ, Brambrink AM, Lehmann C, Portera-Cailliau C, Koehler R, Rothstein J, Traystman RJ. Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum. Annals of Neurology. 42: 335-48. PMID 9307255 DOI: 10.1002/ana.410420310  1
1997 Sze CI, Troncoso JC, Kawas C, Mouton P, Price DL, Martin LJ. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 56: 933-44. PMID 9258263  1
1997 Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo. Nature Medicine. 3: 756-60. PMID 9212102 DOI: 10.1038/nm0797-756  1
1997 Portera-Cailliau C, Price DL, Martin LJ. Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: further evidence for an apoptosis-necrosis continuum. The Journal of Comparative Neurology. 378: 88-104. PMID 9120056 DOI: 10.1002/(SICI)1096-9861(19970203)378:1<88::AID-CNE5>3.0.CO;2-G  1
1997 Portera-Cailliau C, Price DL, Martin LJ. Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum. The Journal of Comparative Neurology. 378: 70-87. PMID 9120055  1
1996 Calhoun ME, Jucker M, Martin LJ, Thinakaran G, Price DL, Mouton PR. Comparative evaluation of synaptophysin-based methods for quantification of synapses. Journal of Neurocytology. 25: 821-8. PMID 9023727  1
1996 Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 7513-25. PMID 8922407  1
1996 Ginsberg SD, Rothstein JD, Price DL, Martin LJ. Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus. Journal of Neurochemistry. 67: 1208-16. PMID 8752128  1
1996 Portera-Cailliau C, Price DL, Martin LJ. N-methyl-D-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies. Journal of Neurochemistry. 66: 692-700. PMID 8592141  1
1995 Furuta A, Price DL, Pardo CA, Troncoso JC, Xu ZS, Taniguchi N, Martin LJ. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. The American Journal of Pathology. 146: 357-67. PMID 7856748  1
1995 Ginsberg SD, Price DL, Blackstone CD, Huganir RL, Martin LJ. The AMPA glutamate receptor GluR3 is enriched in oxytocinergic magnocellular neurons and is localized at synapses. Neuroscience. 65: 563-75. PMID 7777169 DOI: 10.1016/0306-4522(94)00513-5  1
1995 Ginsberg SD, Price DL, Blackstone CD, Huganir RL, Martin LJ. Non-NMDA glutamate receptors are present throughout the primate hypothalamus. The Journal of Comparative Neurology. 353: 539-52. PMID 7759614 DOI: 10.1002/cne.903530406  1
1995 Sisodia SS, Martin LJ, Walker LC, Borchelt DR, Price DL. Cellular and molecular biology of Alzheimer's disease and animal models. Neuroimaging Clinics of North America. 5: 59-68. PMID 7743085  1
1994 Martin LJ, Pardo CA, Cork LC, Price DL. Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. The American Journal of Pathology. 145: 1358-81. PMID 7992840  1
1993 Martin LJ, Blackstone CD, Levey AI, Huganir RL, Price DL. AMPA glutamate receptor subunits are differentially distributed in rat brain. Neuroscience. 53: 327-58. PMID 8388083 DOI: 10.1016/0306-4522(93)90199-P  1
1993 Martin LJ, Blackstone CD, Levey AI, Huganir RL, Price DL. Cellular localizations of AMPA glutamate receptors within the basal forebrain magnocellular complex of rat and monkey. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2249-63. PMID 8386757  1
1993 Martin LJ, Blackstone CD, Huganir RL, Price DL. The striatal mosaic in primates: striosomes and matrix are differentially enriched in ionotropic glutamate receptor subunits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 782-92. PMID 7678861  1
1992 Jucker M, Walker LC, Martin LJ, Kitt CA, Kleinman HK, Ingram DK, Price DL. Age-associated inclusions in normal and transgenic mouse brain. Science (New York, N.Y.). 255: 1443-5. PMID 1542796  1
1992 Price DL, Martin LJ, Clatterbuck RE, Koliatsos VE, Sisodia SS, Walker LC, Cork LC. Neuronal degeneration in human diseases and animal models. Journal of Neurobiology. 23: 1277-94. PMID 1469388 DOI: 10.1002/neu.480230916  1
1992 Price DL, Walker LC, Martin LJ, Sisodia SS. Amyloidosis in aging and Alzheimer's disease. The American Journal of Pathology. 141: 767-72. PMID 1415474  1
1992 Price DL, Martin LJ, Sisodia SS, Walker LC, Cork LC. Alzheimer's disease-type brain abnormalities in animal models. Progress in Clinical and Biological Research. 379: 271-87. PMID 1409750  1
1992 Blackstone CD, Moss SJ, Martin LJ, Levey AI, Price DL, Huganir RL. Biochemical characterization and localization of a non-N-methyl-D-aspartate glutamate receptor in rat brain. Journal of Neurochemistry. 58: 1118-26. PMID 1371146  1
1992 Blackstone CD, Levey AI, Martin LJ, Price DL, Huganir RL. Immunological detection of glutamate receptor subtypes in human central nervous system. Annals of Neurology. 31: 680-3. PMID 1325139 DOI: 10.1002/ana.410310620  1
1992 Martin LJ, Blackstone CD, Huganir RL, Price DL. Cellular localization of a metabotropic glutamate receptor in rat brain. Neuron. 9: 259-70. PMID 1323311 DOI: 10.1016/0896-6273(92)90165-A  1
1991 Martin LJ, Powers RE, Dellovade TL, Price DL. The bed nucleus-amygdala continuum in human and monkey. The Journal of Comparative Neurology. 309: 445-85. PMID 1918444 DOI: 10.1002/cne.903090404  1
1991 Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL. Amyloid precursor protein in aged nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 88: 1461-5. PMID 1899927  1
1991 Price DL, Martin LJ, Sisodia SS, Wagster MV, Koo EH, Walker LC, Koliatsos VE, Cork LC. Aged non-human primates: an animal model of age-associated neurodegenerative disease. Brain Pathology (Zurich, Switzerland). 1: 287-96. PMID 1688300  1
Show low-probability matches.