Mariano Barbacid - Publications

Molecular Oncology Programme CNIO, Madrid, Comunidad de Madrid, Spain 
molecular oncology, mouse models, signaling

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Year Citation  Score
2016 Ambrogio C, Gómez-López G, Falcone M, Vidal A, Nadal E, Crosetto N, Blasco RB, Fernández-Marcos PJ, Sánchez-Céspedes M, Ren X, Wang Z, Ding K, Hidalgo M, Serrano M, Villanueva A, ... ... Barbacid M, et al. Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nature Medicine. PMID 26855149 DOI: 10.1038/nm.4041  0.92
2015 Drosten M, Barbacid M. Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets. Journal of Molecular Medicine (Berlin, Germany). PMID 26526121 DOI: 10.1007/s00109-015-1360-5  0.92
2015 García-Beccaria M, Martínez P, Méndez-Pertuz M, Martínez S, Blanco-Aparicio C, Cañamero M, Mulero F, Ambrogio C, Flores JM, Megias D, Barbacid M, Pastor J, Blasco MA. Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage. Embo Molecular Medicine. PMID 25971796 DOI: 10.15252/emmm.201404497  0.92
2015 Agudo-Ibáñez L, Herrero A, Barbacid M, Crespo P. H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. Molecular and Cellular Biology. 35: 1898-914. PMID 25776558 DOI: 10.1128/MCB.01398-14  0.92
2015 Trakala M, Rodríguez-Acebes S, Maroto M, Symonds CE, Santamaría D, Ortega S, Barbacid M, Méndez J, Malumbres M. Functional reprogramming of polyploidization in megakaryocytes. Developmental Cell. 32: 155-67. PMID 25625205 DOI: 10.1016/j.devcel.2014.12.015  0.92
2014 Hernández-Porras I, Fabbiano S, Schuhmacher AJ, Aicher A, Cañamero M, Cámara JA, Cussó L, Desco M, Heeschen C, Mulero F, Bustelo XR, Guerra C, Barbacid M. K-RasV14I recapitulates Noonan syndrome in mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 16395-400. PMID 25359213 DOI: 10.1073/pnas.1418126111  0.92
2014 Ambrogio C, Stern P, Scuoppo C, Kranz H, Barbacid M, Santamaría D. Lentiviral-based approach for the validation of cancer therapeutic targets in vivo. Biotechniques. 57: 179, 181-7. PMID 25312087 DOI: 10.2144/000114214  0.92
2014 Drosten M, Sum EY, Lechuga CG, Simón-Carrasco L, Jacob HK, García-Medina R, Huang S, Beijersbergen RL, Bernards R, Barbacid M. Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 111: 15155-60. PMID 25288756 DOI: 10.1073/pnas.1417549111  0.92
2014 Ambrogio C, Carmona FJ, Vidal A, Falcone M, Nieto P, Romero OA, Puertas S, Vizoso M, Nadal E, Poggio T, Sánchez-Céspedes M, Esteller M, Mulero F, Voena C, Chiarle R, ... Barbacid M, et al. Modeling lung cancer evolution and preclinical response by orthotopic mouse allografts. Cancer Research. 74: 5978-88. PMID 25217522 DOI: 10.1158/0008-5472.CAN-14-1606  0.92
2014 Mainardi S, Mijimolle N, Francoz S, Vicente-Dueñas C, Sánchez-García I, Barbacid M. Identification of cancer initiating cells in K-Ras driven lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. 111: 255-60. PMID 24367082 DOI: 10.1073/pnas.1320383110  0.92
2014 Drosten M, Lechuga CG, Barbacid M. Ras signaling is essential for skin development. Oncogene. 33: 2857-65. PMID 23831572 DOI: 10.1038/onc.2013.254  0.92
2014 Guerra C, Barbacid M. Mouse models of RAS-induced tumors and developmental disorders Ras Superfamily Small G Proteins: Biology and Mechanisms 1: General Features, Signaling. 211-231. DOI: 10.1007/978-3-7091-1806-1_10  0.92
2013 Azrak SS, Ginel-Picardo A, Drosten M, Barbacid M, Santos E. Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications. Bmc Genomics. 14: 731. PMID 24156637 DOI: 10.1186/1471-2164-14-731  0.92
2013 Drosten M, Lechuga CG, Barbacid M. Genetic analysis of Ras genes in epidermal development and tumorigenesis. Small Gtpases. 4: 236-41. PMID 24150175 DOI: 10.4161/sgtp.26905  0.92
2013 Guerra C, Barbacid M. Genetically engineered mouse models of pancreatic adenocarcinoma. Molecular Oncology. 7: 232-47. PMID 23506980 DOI: 10.1016/j.molonc.2013.02.002  0.92
2013 Berns A, Barbacid M. Mouse models of cancer. Molecular Oncology. 7: 143-5. PMID 23499582 DOI: 10.1016/j.molonc.2013.02.014  0.92
2012 Navas C, Hernández-Porras I, Schuhmacher AJ, Sibilia M, Guerra C, Barbacid M. EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma. Cancer Cell. 22: 318-30. PMID 22975375 DOI: 10.1016/j.ccr.2012.08.001  0.92
2012 Barbacid M. Opening a new GATAway for treating KRAS-driven lung tumors. Cancer Cell. 21: 598-600. PMID 22624710 DOI: 10.1016/j.ccr.2012.04.032  0.92
2012 Ganuza M, Sáiz-Ladera C, Cañamero M, Gómez G, Schneider R, Blasco MA, Pisano D, Paramio JM, Santamaría D, Barbacid M. Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion. The Embo Journal. 31: 2498-510. PMID 22505032 DOI: 10.1038/emboj.2012.94  0.92
2012 Pérez-Mancera PA, Guerra C, Barbacid M, Tuveson DA. What we have learned about pancreatic cancer from mouse models. Gastroenterology. 142: 1079-92. PMID 22406637 DOI: 10.1053/j.gastro.2012.03.002  0.92
2011 Göritz C, Dias DO, Tomilin N, Barbacid M, Shupliakov O, Frisén J. A pericyte origin of spinal cord scar tissue. Science (New York, N.Y.). 333: 238-42. PMID 21737741 DOI: 10.1126/science.1203165  0.92
2011 Guerra C, Collado M, Navas C, Schuhmacher AJ, Hernández-Porras I, Cañamero M, Rodriguez-Justo M, Serrano M, Barbacid M. Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence. Cancer Cell. 19: 728-39. PMID 21665147 DOI: 10.1016/j.ccr.2011.05.011  0.92
2011 Hennessy EJ, Sheedy FJ, Santamaria D, Barbacid M, O'Neill LA. Toll-like receptor-4 (TLR4) down-regulates microRNA-107, increasing macrophage adhesion via cyclin-dependent kinase 6. The Journal of Biological Chemistry. 286: 25531-9. PMID 21628465 DOI: 10.1074/jbc.M111.256206  0.92
2011 Blasco RB, Francoz S, Santamaría D, Cañamero M, Dubus P, Charron J, Baccarini M, Barbacid M. c-Raf, but not B-Raf, is essential for development of K-Ras oncogene-driven non-small cell lung carcinoma. Cancer Cell. 19: 652-63. PMID 21514245 DOI: 10.1016/j.ccr.2011.04.002  0.92
2011 Urosevic J, Sauzeau V, Soto-Montenegro ML, Reig S, Desco M, Wright EM, Cañamero M, Mulero F, Ortega S, Bustelo XR, Barbacid M. Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome. Proceedings of the National Academy of Sciences of the United States of America. 108: 5015-20. PMID 21383153 DOI: 10.1073/pnas.1016933108  0.92
2011 Beukelaers P, Vandenbosch R, Caron N, Nguyen L, Belachew S, Moonen G, Kiyokawa H, Barbacid M, Santamaria D, Malgrange B. Cdk6-dependent regulation of G(1) length controls adult neurogenesis. Stem Cells (Dayton, Ohio). 29: 713-24. PMID 21319271 DOI: 10.1002/stem.616  0.92
2011 Frezzetti D, De Menna M, Zoppoli P, Guerra C, Ferraro A, Bello AM, De Luca P, Calabrese C, Fusco A, Ceccarelli M, Zollo M, Barbacid M, Di Lauro R, De Vita G. Upregulation of miR-21 by Ras in vivo and its role in tumor growth. Oncogene. 30: 275-86. PMID 20956945 DOI: 10.1038/onc.2010.416  0.92
2010 Hyter S, Bajaj G, Liang X, Barbacid M, Ganguli-Indra G, Indra AK. Loss of nuclear receptor RXRα in epidermal keratinocytes promotes the formation of Cdk4-activated invasive melanomas. Pigment Cell & Melanoma Research. 23: 635-48. PMID 20629968 DOI: 10.1111/j.1755-148X.2010.00732.x  0.92
2010 Puyol M, Martín A, Dubus P, Mulero F, Pizcueta P, Khan G, Guerra C, Santamaría D, Barbacid M. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell. 18: 63-73. PMID 20609353 DOI: 10.1016/j.ccr.2010.05.025  0.92
2010 Lauth M, Bergström A, Shimokawa T, Tostar U, Jin Q, Fendrich V, Guerra C, Barbacid M, ToftgÃ¥rd R. DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nature Structural & Molecular Biology. 17: 718-25. PMID 20512148 DOI: 10.1038/nsmb.1833  0.92
2010 Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, Barbacid M. Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival. The Embo Journal. 29: 1091-104. PMID 20150892 DOI: 10.1038/emboj.2010.7  0.92
2010 Campaner S, Doni M, Hydbring P, Verrecchia A, Bianchi L, Sardella D, Schleker T, Perna D, Tronnersjö S, Murga M, Fernandez-Capetillo O, Barbacid M, Larsson LG, Amati B. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nature Cell Biology. 12: 54-9; sup pp 1-14. PMID 20010815 DOI: 10.1038/ncb2004  0.92
2009 Cerqueira A, Santamaría D, Martínez-Pastor B, Cuadrado M, Fernández-Capetillo O, Barbacid M. Overall Cdk activity modulates the DNA damage response in mammalian cells. The Journal of Cell Biology. 187: 773-80. PMID 19995934 DOI: 10.1083/jcb.200903033  0.92
2009 Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I. The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma. The Journal of Pathology. 219: 205-13. PMID 19585519 DOI: 10.1002/path.2585  0.92
2009 Urosevic J, Sum EY, Moneo V, Drosten M, Dhawahir A, Becerra M, Carnero A, Barbacid M. Using cells devoid of RAS proteins as tools for drug discovery. Molecular Carcinogenesis. 48: 1038-47. PMID 19526460 DOI: 10.1002/mc.20555  0.92
2009 Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nature Reviews. Cancer. 9: 153-66. PMID 19238148 DOI: 10.1038/nrc2602  0.92
2008 Boyle P, Anderson BO, Andersson LC, Ariyaratne Y, Auleley GR, Barbacid M, Bartelink H, Baselga J, Behbehani K, Belardelli F, Berns A, Bishop J, Brawley O, Burns H, Clanton M, et al. Need for global action for cancer control. Annals of Oncology : Official Journal of the European Society For Medical Oncology / Esmo. 19: 1519-21. PMID 18723552 DOI: 10.1093/annonc/mdn426  0.92
2008 Schuhmacher AJ, Guerra C, Sauzeau V, Cañamero M, Bustelo XR, Barbacid M. A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition. The Journal of Clinical Investigation. 118: 2169-79. PMID 18483625 DOI: 10.1172/JCI34385  0.92
2008 Atanasoski S, Boentert M, De Ventura L, Pohl H, Baranek C, Beier K, Young P, Barbacid M, Suter U. Postnatal Schwann cell proliferation but not myelination is strictly and uniquely dependent on cyclin-dependent kinase 4 (cdk4). Molecular and Cellular Neurosciences. 37: 519-27. PMID 18191580 DOI: 10.1016/j.mcn.2007.11.005  0.92
2008 Malumbres M, Pevarello P, Barbacid M, Bischoff JR. CDK inhibitors in cancer therapy: what is next? Trends in Pharmacological Sciences. 29: 16-21. PMID 18054800 DOI: 10.1016/  0.92
2007 Barrière C, Santamaría D, Cerqueira A, Galán J, Martín A, Ortega S, Malumbres M, Dubus P, Barbacid M. Mice thrive without Cdk4 and Cdk2. Molecular Oncology. 1: 72-83. PMID 19383288 DOI: 10.1016/j.molonc.2007.03.001  0.92
2007 Santamaría D, Barrière C, Cerqueira A, Hunt S, Tardy C, Newton K, Cáceres JF, Dubus P, Malumbres M, Barbacid M. Cdk1 is sufficient to drive the mammalian cell cycle. Nature. 448: 811-5. PMID 17700700 DOI: 10.1038/nature06046  0.92
2007 Barbacid M. Returning home. Cell. 129: 641-4. PMID 17512394 DOI: 10.1016/j.cell.2007.05.010  0.92
2007 Ventura JJ, Tenbaum S, Perdiguero E, Huth M, Guerra C, Barbacid M, Pasparakis M, Nebreda AR. p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nature Genetics. 39: 750-8. PMID 17468755 DOI: 10.1038/ng2037  0.92
2007 Guerra C, Schuhmacher AJ, Cañamero M, Grippo PJ, Verdaguer L, Pérez-Gallego L, Dubus P, Sandgren EP, Barbacid M. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 11: 291-302. PMID 17349585 DOI: 10.1016/j.ccr.2007.01.012  0.92
2007 Malumbres M, Barbacid M. Cell cycle kinases in cancer. Current Opinion in Genetics & Development. 17: 60-5. PMID 17208431 DOI: 10.1016/j.gde.2006.12.008  0.92
2006 Sansom OJ, Meniel V, Wilkins JA, Cole AM, Oien KA, Marsh V, Jamieson TJ, Guerra C, Ashton GH, Barbacid M, Clarke AR. Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 14122-7. PMID 16959882 DOI: 10.1073/pnas.0604130103  0.92
2006 Tormo D, Ferrer A, Gaffal E, Wenzel J, Basner-Tschakarjan E, Steitz J, Heukamp LC, Gütgemann I, Buettner R, Malumbres M, Barbacid M, Merlino G, Tüting T. Rapid growth of invasive metastatic melanoma in carcinogen-treated hepatocyte growth factor/scatter factor-transgenic mice carrying an oncogenic CDK4 mutation. The American Journal of Pathology. 169: 665-72. PMID 16877364 DOI: 10.2353/ajpath.2006.060017  0.92
2006 Hacker E, Muller HK, Irwin N, Gabrielli B, Lincoln D, Pavey S, Powell MB, Malumbres M, Barbacid M, Hayward N, Walker G. Spontaneous and UV radiation-induced multiple metastatic melanomas in Cdk4R24C/R24C/TPras mice. Cancer Research. 66: 2946-52. PMID 16540642 DOI: 10.1158/0008-5472.CAN-05-3196  0.92
2006 Malumbres M, Barbacid M. Is Cyclin D1-CDK4 kinase a bona fide cancer target? Cancer Cell. 9: 2-4. PMID 16413464 DOI: 10.1016/j.ccr.2005.12.026  0.92
2006 Duensing A, Liu Y, Tseng M, Malumbres M, Barbacid M, Duensing S. Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication. Oncogene. 25: 2943-9. PMID 16331279 DOI: 10.1038/sj.onc.1209310  0.92
2006 Steitz J, Büchs S, Tormo D, Ferrer A, Wenzel J, Huber C, Wölfel T, Barbacid M, Malumbres M, Tüting T. Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin. International Journal of Cancer. Journal International Du Cancer. 118: 373-80. PMID 16049960 DOI: 10.1002/ijc.21349  0.92
2005 Barbacid M, Ortega S, Sotillo R, Odajima J, Martín A, Santamaría D, Dubus P, Malumbres M. Cell cycle and cancer: genetic analysis of the role of cyclin-dependent kinases. Cold Spring Harbor Symposia On Quantitative Biology. 70: 233-40. PMID 16869759 DOI: 10.1101/sqb.2005.70.005  0.92
2005 Malumbres M, Barbacid M. Mammalian cyclin-dependent kinases. Trends in Biochemical Sciences. 30: 630-41. PMID 16236519 DOI: 10.1016/j.tibs.2005.09.005  0.92
2005 Abella A, Dubus P, Malumbres M, Rane SG, Kiyokawa H, Sicard A, Vignon F, Langin D, Barbacid M, Fajas L. Cdk4 promotes adipogenesis through PPARgamma activation. Cell Metabolism. 2: 239-49. PMID 16213226 DOI: 10.1016/j.cmet.2005.09.003  0.92
2005 Collado M, Gil J, Efeyan A, Guerra C, Schuhmacher AJ, Barradas M, Benguría A, Zaballos A, Flores JM, Barbacid M, Beach D, Serrano M. Tumour biology: senescence in premalignant tumours. Nature. 436: 642. PMID 16079833 DOI: 10.1038/436642a  0.92
2005 Martín A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M, Barbacid M. Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1). Cancer Cell. 7: 591-8. PMID 15950907 DOI: 10.1016/j.ccr.2005.05.006  0.92
2005 Sotillo R, Renner O, Dubus P, Ruiz-Cabello J, Martín-Caballero J, Barbacid M, Carnero A, Malumbres M. Cooperation between Cdk4 and p27kip1 in tumor development: a preclinical model to evaluate cell cycle inhibitors with therapeutic activity. Cancer Research. 65: 3846-52. PMID 15867383 DOI: 10.1158/0008-5472.CAN-04-4195  0.92
2005 Mijimolle N, Velasco J, Dubus P, Guerra C, Weinbaum CA, Casey PJ, Campuzano V, Barbacid M. Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development. Cancer Cell. 7: 313-24. PMID 15837621 DOI: 10.1016/j.ccr.2005.03.004  0.92
2004 Auwerx J, Avner P, Baldock R, Ballabio A, Balling R, Barbacid M, Berns A, Bradley A, Brown S, Carmeliet P, Chambon P, Cox R, Davidson D, Davies K, Duboule D, et al. The European dimension for the mouse genome mutagenesis program. Nature Genetics. 36: 925-7. PMID 15340424 DOI: 10.1038/ng0904-925  0.92
2004 Malumbres M, Sotillo R, Santamaría D, Galán J, Cerezo A, Ortega S, Dubus P, Barbacid M. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell. 118: 493-504. PMID 15315761 DOI: 10.1016/j.cell.2004.08.002  0.92
2004 Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C, Barbacid M, Gomis R. Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes. Diabetologia. 47: 686-94. PMID 15298346 DOI: 10.1007/s00125-004-1372-0  0.92
2003 Guerra C, Mijimolle N, Dhawahir A, Dubus P, Barradas M, Serrano M, Campuzano V, Barbacid M. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell. 4: 111-20. PMID 12957286 DOI: 10.1016/S1535-6108(03)00191-0  0.92
2003 Ortega S, Prieto I, Odajima J, Martín A, Dubus P, Sotillo R, Barbero JL, Malumbres M, Barbacid M. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nature Genetics. 35: 25-31. PMID 12923533 DOI: 10.1038/ng1232  0.92
2003 Martín J, Hunt SL, Dubus P, Sotillo R, Néhmé-Pélluard F, Magnuson MA, Parlow AF, Malumbres M, Ortega S, Barbacid M. Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number. Oncogene. 22: 5261-9. PMID 12917627 DOI: 10.1038/sj.onc.1206506  0.92
2003 Malumbres M, Hunt SL, Sotillo R, Martín J, Odajima J, Martín A, Dubus P, Ortega S, Barbacid M. Driving the cell cycle to cancer. Advances in Experimental Medicine and Biology. 532: 1-11. PMID 12908544  0.92
2003 Malumbres M, Barbacid M. RAS oncogenes: the first 30 years. Nature Reviews. Cancer. 3: 459-65. PMID 12778136 DOI: 10.1038/nrc1097  0.92
2002 Menéndez JA, Ropero S, del Barbacid MM, Montero S, Solanas M, Escrich E, Cortés-Funes H, Colomer R. Synergistic interaction between vinorelbine and gamma-linolenic acid in breast cancer cells. Breast Cancer Research and Treatment. 72: 203-19. PMID 12058962  0.92
2002 Ortega S, Malumbres M, Barbacid M. Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochimica Et Biophysica Acta. 1602: 73-87. PMID 11960696 DOI: 10.1016/S0304-419X(02)00037-9  0.92
2002 Ortega S, Malumbres M, Barbacid M. Cell cycle and cancer: The G1 restriction point and the G1/S transition Current Genomics. 3: 245-263. DOI: 10.2174/1389202023350444  0.92
2001 Malumbres M, Barbacid M. To cycle or not to cycle: a critical decision in cancer. Nature Reviews. Cancer. 1: 222-31. PMID 11902577 DOI: 10.1038/35106065  0.92
2001 Sotillo R, Dubus P, Martín J, de la Cueva E, Ortega S, Malumbres M, Barbacid M. Wide spectrum of tumors in knock-in mice carrying a Cdk4 protein insensitive to INK4 inhibitors. The Embo Journal. 20: 6637-47. PMID 11726500 DOI: 10.1093/emboj/20.23.6637  0.92
2001 Sotillo R, García JF, Ortega S, Martin J, Dubus P, Barbacid M, Malumbres M. Invasive melanoma in Cdk4-targeted mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 13312-7. PMID 11606789 DOI: 10.1073/pnas.241338598  0.92
2001 Matsuo S, Ichikawa H, Henderson TA, Silos-Santiago I, Barbacid M, Arends JJ, Jacquin MF. trkA modulation of developing somatosensory neurons in oro-facial tissues: tooth pulp fibers are absent in trkA knockout mice. Neuroscience. 105: 747-60. PMID 11516838 DOI: 10.1016/S0306-4522(01)00223-8  0.92
2001 Tedford K, Nitschke L, Girkontaite I, Charlesworth A, Chan G, Sakk V, Barbacid M, Fischer KD. Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling. Nature Immunology. 2: 548-55. PMID 11376343 DOI: 10.1038/88756  0.92
2001 Zindy F, den Besten W, Chen B, Rehg JE, Latres E, Barbacid M, Pollard JW, Sherr CJ, Cohen PE, Roussel MF. Control of spermatogenesis in mice by the cyclin D-dependent kinase inhibitors p18(Ink4c) and p19(Ink4d). Molecular and Cellular Biology. 21: 3244-55. PMID 11287627 DOI: 10.1128/MCB.21.9.3244-3255.2001  0.92
2000 Malumbres M, Ortega S, Barbacid M. Genetic analysis of mammalian cyclin-dependent kinases and their inhibitors. Biological Chemistry. 381: 827-38. PMID 11076015 DOI: 10.1515/BC.2000.105  0.92
2000 Latres E, Malumbres M, Sotillo R, Martín J, Ortega S, Martín-Caballero J, Flores JM, Cordón-Cardo C, Barbacid M. Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis. The Embo Journal. 19: 3496-506. PMID 10880462 DOI: 10.1093/emboj/19.13.3496  0.92
2000 Feldheim DA, Kim YI, Bergemann AD, Frisén J, Barbacid M, Flanagan JG. Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping. Neuron. 25: 563-74. PMID 10774725  0.92
1999 Frisén J, Holmberg J, Barbacid M. Ephrins and their Eph receptors: multitalented directors of embryonic development. The Embo Journal. 18: 5159-65. PMID 10508149 DOI: 10.1093/emboj/18.19.5159  0.92
1999 Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, Barbacid M. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia. Nature Genetics. 22: 44-52. PMID 10319860 DOI: 10.1038/8751  0.92
1998 Fritzsch B, Barbacid M, Silos-Santiago I. Nerve dependency of developing and mature sensory receptor cells. Annals of the New York Academy of Sciences. 855: 14-27. PMID 9929583  0.92
1998 Feldheim DA, Vanderhaeghen P, Hansen MJ, Frisén J, Lu Q, Barbacid M, Flanagan JG. Topographic guidance labels in a sensory projection to the forebrain. Neuron. 21: 1303-13. PMID 9883724 DOI: 10.1016/S0896-6273(00)80650-9  0.92
1998 Fritzsch B, Barbacid M, Silos-Santiago I. The combined effects of trkB and trkC mutations on the innervation of the inner ear. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 16: 493-505. PMID 9881298 DOI: 10.1016/S0736-5748(98)00043-4  0.92
1998 de Castro F, Silos-Santiago I, López de Armentia M, Barbacid M, Belmonte C. Corneal innervation and sensitivity to noxious stimuli in trkA knockout mice. The European Journal of Neuroscience. 10: 146-52. PMID 9753121 DOI: 10.1046/j.1460-9568.1998.00037.x  0.92
1998 Martínez A, Alcántara S, Borrell V, Del Río JA, Blasi J, Otal R, Campos N, Boronat A, Barbacid M, Silos-Santiago I, Soriano E. TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7336-50. PMID 9736654  0.92
1998 Rice FL, Albers KM, Davis BM, Silos-Santiago I, Wilkinson GA, LeMaster AM, Ernfors P, Smeyne RJ, Aldskogius H, Phillips HS, Barbacid M, DeChiara TM, Yancopoulos GD, Dunne CE, Fundin BT. Differential dependency of unmyelinated and A delta epidermal and upper dermal innervation on neurotrophins, trk receptors, and p75LNGFR. Developmental Biology. 198: 57-81. PMID 9640332 DOI: 10.1006/dbio.1998.8861  0.92
1998 Fischer KD, Kong YY, Nishina H, Tedford K, Marengère LE, Kozieradzki I, Sasaki T, Starr M, Chan G, Gardener S, Nghiem MP, Bouchard D, Barbacid M, Bernstein A, Penninger JM. Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Current Biology : Cb. 8: 554-62. PMID 9601639  0.92
1998 Frisén J, Yates PA, McLaughlin T, Friedman GC, O'Leary DD, Barbacid M. Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system. Neuron. 20: 235-43. PMID 9491985 DOI: 10.1016/S0896-6273(00)80452-3  0.92
1997 Bustelo XR, Crespo P, López-Barahona M, Gutkind JS, Barbacid M. Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation. Oncogene. 15: 2511-20. PMID 9399639  0.92
1997 Fundin BT, Silos-Santiago I, Ernfors P, Fagan AM, Aldskogius H, DeChiara TM, Phillips HS, Barbacid M, Yancopoulos GD, Rice FL. Differential dependency of cutaneous mechanoreceptors on neurotrophins, trk receptors, and P75 LNGFR. Developmental Biology. 190: 94-116. PMID 9331334 DOI: 10.1006/dbio.1997.8658  0.92
1997 Mañes S, Mira E, Barbacid MM, Ciprés A, Fernández-Resa P, Buesa JM, Mérida I, Aracil M, Márquez G, Martínez-A C. Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3. The Journal of Biological Chemistry. 272: 25706-12. PMID 9325295 DOI: 10.1074/jbc.272.41.25706  0.92
1997 Frisén J, Barbacid M. Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system. Cell and Tissue Research. 290: 209-15. PMID 9321682 DOI: 10.1007/s004410050925  0.92
1997 Fagan AM, Garber M, Barbacid M, Silos-Santiago I, Holtzman DM. A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7644-54. PMID 9315886  0.92
1997 Fritzsch B, Sarai PA, Barbacid M, Silos-Santiago I. Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 15: 563-76. PMID 9263033 DOI: 10.1016/S0736-5748(96)00111-6  0.92
1997 Rosa JL, Barbacid M. A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70. Oncogene. 15: 1-6. PMID 9233772 DOI: 10.1038/sj.onc.1201170  0.92
1997 Park S, Frisén J, Barbacid M. Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. The Embo Journal. 16: 3106-14. PMID 9214628 DOI: 10.1093/emboj/16.11.3106  0.92
1997 Yan Y, Frisén J, Lee MH, Massagué J, Barbacid M. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development. Genes & Development. 11: 973-83. PMID 9136926  0.92
1997 Alcántara S, Frisén J, del Río JA, Soriano E, Barbacid M, Silos-Santiago I. TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 3623-33. PMID 9133385  0.92
1997 Quesada AR, Barbacid MM, Mira E, Fernández-Resa P, Márquez G, Aracil M. Evaluation of fluorometric and zymographic methods as activity assays for stromelysins and gelatinases. Clinical & Experimental Metastasis. 15: 26-32. PMID 9009103 DOI: 10.1023/A:1018480222301  0.92
1996 Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaró S, Barbacid M. p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins. The Embo Journal. 15: 4262-73. PMID 8861955  0.92
1996 Garrido T, Riese HH, Quesada AR, Barbacid MM, Aracil M. Quantitative assay for cell invasion using the fluorogenic substrate 2',7'-Bis(2-carboxyethyl)-5 (and -6)-carboxyfluorescein acetoxymethylester. Analytical Biochemistry. 235: 234-6. PMID 8833333 DOI: 10.1006/abio.1996.0117  0.92
1996 Fagan AM, Zhang H, Landis S, Smeyne RJ, Silos-Santiago I, Barbacid M. TrkA, but not TrkC, receptors are essential for survival of sympathetic neurons in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 6208-18. PMID 8815902  0.92
1996 White FA, Silos-Santiago I, Molliver DC, Nishimura M, Phillips H, Barbacid M, Snider WD. Synchronous onset of NGF and TrkA survival dependence in developing dorsal root ganglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 4662-72. PMID 8764654  0.92
1996 Crespo P, Bustelo XR, Aaronson DS, Coso OA, Lopez-Barahona M, Barbacid M, Gutkind JS. Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav. Oncogene. 13: 455-60. PMID 8760286  0.92
1996 Erickson JT, Conover JC, Borday V, Champagnat J, Barbacid M, Yancopoulos G, Katz DM. Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 5361-71. PMID 8757249  0.92
1996 Schuebel KE, Bustelo XR, Nielsen DA, Song BJ, Barbacid M, Goldman D, Lee IJ. Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes. Oncogene. 13: 363-71. PMID 8710375  0.92
1996 López de Turiso JA, Fernández P, Barbacid MM, Mira E, Quesada AR, Márquez G, Aracil M. Expression and purification of human matrilysin produced in baculovirus-infected insect cells. Journal of Biotechnology. 46: 235-41. PMID 8672291 DOI: 10.1016/0168-1656(96)00002-8  0.92
1996 Sánchez MP, Silos-Santiago I, Frisén J, He B, Lira SA, Barbacid M. Renal agenesis and the absence of enteric neurons in mice lacking GDNF. Nature. 382: 70-3. PMID 8657306 DOI: 10.1038/382070a0  0.92
1996 López-Barahona M, Bustelo XR, Barbacid M. The TC21 oncoprotein interacts with the Ral guanosine nucleotide dissociation factor. Oncogene. 12: 463-70. PMID 8637701  0.92
1996 Leftheris K, Kline T, Vite GD, Cho YH, Bhide RS, Patel DV, Patel MM, Schmidt RJ, Weller HN, Andahazy ML, Carboni JM, Gullo-Brown JL, Lee FY, Ricca C, Rose WC, ... ... Barbacid M, et al. Development of highly potent inhibitors of Ras farnesyltransferase possessing cellular and in vivo activity. Journal of Medicinal Chemistry. 39: 224-36. PMID 8568812 DOI: 10.1021/jm950642a  0.92
1996 Quesada AR, Barbacid MM, Mira E, Aracil M, Márquez G. Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents. Cancer Letters. 99: 109-14. PMID 8564921 DOI: 10.1016/0304-3835(95)04044-7  0.92
1996 Barbacid M. NGF receptors Growth Factors and Cytokines in Health and Disease. 1: 259-276. DOI: 10.1016/S1874-5687(96)80011-5  0.92
1996 Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M. Corrigendum: p619, A giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins (The EMBO Journal (1996) 15 (4262-4273)) Embo Journal. 15: 5738.  0.92
1995 Bustelo XR, Suen KL, Michael WM, Dreyfuss G, Barbacid M. Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins. Molecular and Cellular Biology. 15: 1324-32. PMID 7862126  0.92
1995 Patel DV, Gordon EM, Schmidt RJ, Weller HN, Young MG, Zahler R, Barbacid M, Carboni JM, Gullo-Brown JL, Hunihan L. Phosphinyl acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase. Journal of Medicinal Chemistry. 38: 435-42. PMID 7853336 DOI: 10.1021/jm00003a006  0.92
1995 Zmuidzinas A, Fischer KD, Lira SA, Forrester L, Bryant S, Bernstein A, Barbacid M. The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro. The Embo Journal. 14: 1-11. PMID 7828581  0.92
1995 Carboni JM, Yan N, Cox AD, Bustelo X, Graham SM, Lynch MJ, Weinmann R, Seizinger BR, Der CJ, Barbacid M. Farnesyltransferase inhibitors are inhibitors of Ras but not R-Ras2/TC21, transformation. Oncogene. 10: 1905-13. PMID 7761092  0.92
1995 Shou C, Wurmser A, Suen KL, Barbacid M, Feig LA, Ling K. Differential response of the Ras exchange factor, Ras-GRF to tyrosine kinase and G protein mediated signals. Oncogene. 10: 1887-93. PMID 7761090  0.92
1995 Manne V, Yan N, Carboni JM, Tuomari AV, Ricca CS, Brown JG, Andahazy ML, Schmidt RJ, Patel D, Zahler R, Weinmann R, Der CJ, Cox AD, Hunt JT, Gordon EM, ... Barbacid M, et al. Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells Oncogene. 10: 1763-1779. PMID 7753553  0.92
1995 Fischer KD, Zmuldzinas A, Gardner S, Barbacid M, Bernstein A, Guidos C. Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+ CD8+ thymocytes. Nature. 374: 474-7. PMID 7700360 DOI: 10.1038/374474a0  0.92
1995 Suen KL, Bustelo XR, Barbacid M. Lack of evidence for the activation of the Ras/Raf mitogenic pathway by 14-3-3 proteins in mammalian cells. Oncogene. 11: 825-31. PMID 7675443  0.92
1995 Silos-Santiago I, Molliver DC, Ozaki S, Smeyne RJ, Fagan AM, Barbacid M, Snider WD. Non-TrkA-expressing small DRG neurons are lost in TrkA deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 5929-42. PMID 7666178  0.92
1995 Barbacid M. Neurotrophic factors and their receptors. Current Opinion in Cell Biology. 7: 148-55. PMID 7612265 DOI: 10.1016/0955-0674(95)80022-0  0.92
1995 Barbacid M. Structural and functional properties of the TRK family of neurotrophin receptors. Annals of the New York Academy of Sciences. 766: 442-58. PMID 7486690 DOI: 10.1111/j.1749-6632.1995.tb26693.x  0.92
1995 Manne V, Ricca CS, Brown JG, Tuomari AV, Yan N, Patel D, Schmidt R, Lynch MJ, Ciosek CP, Carboni JM, Robinson S, Gordon EM, Barbacid M, Seizinger BR, Biller SA. Ras farnesylation as a target for novel antitumor agents: Potent and selective farnesyl diphosphate analog inhibitors of farnesyltransferase Drug Development Research. 34: 121-137. DOI: 10.1002/ddr.430340205  0.92
1994 Lamballe F, Smeyne RJ, Barbacid M. Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 14-28. PMID 8283230  0.92
1994 Kazanietz MG, Bustelo XR, Barbacid M, Kolch W, Mischak H, Wong G, Pettit GR, Bruns JD, Blumberg PM. Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C zeta and the vav and c-raf proto-oncogene products. The Journal of Biological Chemistry. 269: 11590-4. PMID 8157692  0.92
1994 Klein R, Silos-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Snider WD, Barbacid M. Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature. 368: 249-51. PMID 8145824 DOI: 10.1038/368249a0  0.92
1994 Smeyne RJ, Klein R, Schnapp A, Long LK, Bryant S, Lewin A, Lira SA, Barbacid M. Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature. 368: 246-9. PMID 8145823 DOI: 10.1038/368246a0  0.92
1994 Sánchez MP, Tapley P, Saini SS, He B, Pulido D, Barbacid M. Multiple tyrosine protein kinases in rat hippocampal neurons: isolation of Ptk-3, a receptor expressed in proliferative zones of the developing brain. Proceedings of the National Academy of Sciences of the United States of America. 91: 1819-23. PMID 8127887  0.92
1994 Zhu X, Suen KL, Barbacid M, Bolen JB, Fargnoli J. Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation. The Journal of Biological Chemistry. 269: 5518-22. PMID 8119884  0.92
1994 Bustelo XR, Suen KL, Leftheris K, Meyers CA, Barbacid M. Vav cooperates with Ras to transform rodent fibroblasts but is not a Ras GDP/GTP exchange factor. Oncogene. 9: 2405-13. PMID 8036025  0.92
1994 Chalazonitis A, Rothman TP, Chen J, Lamballe F, Barbacid M, Gershon MD. Neurotrophin-3 induces neural crest-derived cells from fetal rat gut to develop in vitro as neurons or glia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 6571-84. PMID 7965061  0.92
1994 Wittekind M, Mapelli C, Farmer BT, Suen KL, Goldfarb V, Tsao J, Lavoie T, Barbacid M, Meyers CA, Mueller L. Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy. Biochemistry. 33: 13531-9. PMID 7947763 DOI: 10.1021/bi00250a004  0.92
1994 Barbacid M. The Trk family of neurotrophin receptors. Journal of Neurobiology. 25: 1386-403. PMID 7852993 DOI: 10.1002/neu.480251107  0.92
1994 Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T. Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav. Molecular and Cellular Biology. 14: 2777-85. PMID 7511210  0.92
1994 Fagan AM, Barbacid M, Smeyne RJ. The role of nerve growth factor family receptors in the development of the mammalian nervous system European Neuropsychopharmacology. 4: 226.  0.92
1993 Bustelo XR, Rubin SD, Suen KL, Carrasco D, Barbacid M. Developmental expression of the vav protooncogene. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 4: 297-308. PMID 8494792  0.92
1993 Marsh HN, Scholz WK, Lamballe F, Klein R, Nanduri V, Barbacid M, Palfrey HC. Signal transduction events mediated by the BDNF receptor gp 145trkB in primary hippocampal pyramidal cell culture. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4281-92. PMID 8410187  0.92
1993 Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL, Barbacid M. Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell. 75: 113-22. PMID 8402890  0.92
1993 Beck KD, Lamballe F, Klein R, Barbacid M, Schauwecker PE, McNeill TH, Finch CE, Hefti F, Day JR. Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4001-14. PMID 8396171  0.92
1993 Lamballe F, Tapley P, Barbacid M. trkC encodes multiple neurotrophin-3 receptors with distinct biological properties and substrate specificities. The Embo Journal. 12: 3083-94. PMID 8344249  0.92
1993 Barbacid M. Nerve growth factor: a tale of two receptors. Oncogene. 8: 2033-42. PMID 8336933  0.92
1993 Steininger TL, Wainer BH, Klein R, Barbacid M, Palfrey HC. High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain. Brain Research. 612: 330-5. PMID 8330208 DOI: 10.1016/0006-8993(93)91681-H  0.92
1993 Suen KL, Bustelo XR, Pawson T, Barbacid M. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors. Molecular and Cellular Biology. 13: 5500-12. PMID 7689150  0.92
1993 Ip NY, Stitt TN, Tapley P, Klein R, Glass DJ, Fandl J, Greene LA, Barbacid M, Yancopoulos GD. Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron. 10: 137-49. PMID 7679912 DOI: 10.1016/0896-6273(93)90306-C  0.92
1992 Liu WC, Barbacid M, Bulgar M, Clark JM, Crosswell AR, Dean L, Doyle TW, Fernandes PB, Huang S, Manne V. 10'-Desmethoxystreptonigrin, a novel analog of streptonigrin. The Journal of Antibiotics. 45: 454-7. PMID 1592677  0.92
1992 Alai M, Mui AL, Cutler RL, Bustelo XR, Barbacid M, Krystal G. Steel factor stimulates the tyrosine phosphorylation of the proto-oncogene product, p95vav, in human hemopoietic cells. The Journal of Biological Chemistry. 267: 18021-5. PMID 1381360  0.92
1992 Bustelo XR, Barbacid M. Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells. Science (New York, N.Y.). 256: 1196-9. PMID 1375396  0.92
1992 Klein R, Lamballe F, Bryant S, Barbacid M. The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron. 8: 947-56. PMID 1375038 DOI: 10.1016/0896-6273(92)90209-V  0.92
1992 Pulido D, Campuzano S, Koda T, Modolell J, Barbacid M. Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion molecule. The Embo Journal. 11: 391-404. PMID 1371458  0.92
1992 Tapley P, Lamballe F, Barbacid M. K252a is a selective inhibitor of the tyrosine protein kinase activity of the trk family of oncogenes and neurotrophin receptors. Oncogene. 7: 371-81. PMID 1312698  0.92
1992 Bustelo XR, Ledbetter JA, Barbacid M. Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates. Nature. 356: 68-71. PMID 1311423 DOI: 10.1038/356068a0  0.92
1992 Jing S, Tapley P, Barbacid M. Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron. 9: 1067-79. PMID 1281417 DOI: 10.1016/0896-6273(92)90066-M  0.92
1992 Liu WC, Barbacid M, Bulgar M, Clark JM, Crosswell AR, Dean L, Doyle TW, Fernandes PB, Huang S, Manne V, Pirnik DM, Wells JS, Meyer E. Correction: 10'-Desmethoxystreptonigrin, a novel analog of streptonigrin (Journal of Antibiotics (1992) (45 No. 4) (454-457)) Journal of Antibiotics. 45: C3.  0.92
1991 Coppola J, Bryant S, Koda T, Conway D, Barbacid M. Mechanism of activation of the vav protooncogene. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 2: 95-105. PMID 2069873  0.92
1991 Garlick DS, Sukumar S, Barbacid M, Petit D, Hamer PJ, Leav I, Lavecchio JA, Trimpe KL, Carney WP. Generation of monoclonal antibodies specific for ras p21 Glu-12 oncoproteins: detection in carcinogen-induced mammary carcinomas. Hybridoma. 10: 95-102. PMID 2032737  0.92
1991 Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M. The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 65: 189-97. PMID 1849459 DOI: 10.1016/0092-8674(91)90419-Y  0.92
1991 Lamballe F, Klein R, Barbacid M. The trk family of oncogenes and neurotrophin receptors. Princess Takamatsu Symposia. 22: 153-70. PMID 1844238  0.92
1991 Barbacid M, Lamballe F, Pulido D, Klein R. The trk family of tyrosine protein kinase receptors. Biochimica Et Biophysica Acta. 1072: 115-27. PMID 1751544 DOI: 10.1016/0304-419X(91)90010-I  0.92
1991 Lamballe F, Klein R, Barbacid M. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell. 66: 967-79. PMID 1653651 DOI: 10.1016/0092-8674(91)90442-2  0.92
1991 Klein R, Nanduri V, Jing SA, Lamballe F, Tapley P, Bryant S, Cordon-Cardo C, Jones KR, Reichardt LF, Barbacid M. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell. 66: 395-403. PMID 1649702 DOI: 10.1016/0092-8674(91)90628-C  0.92
1991 Cordon-Cardo C, Tapley P, Jing SQ, Nanduri V, O'Rourke E, Lamballe F, Kovary K, Klein R, Jones KR, Reichardt LF. The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell. 66: 173-83. PMID 1649007 DOI: 10.1016/0092-8674(91)90149-S  0.92
1990 Sukumar S, Barbacid M. Specific patterns of oncogene activation in transplacentally induced tumors. Proceedings of the National Academy of Sciences of the United States of America. 87: 718-22. PMID 2405388  0.92
1990 Martin-Zanca D, Barbacid M, Parada LF. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes & Development. 4: 683-94. PMID 2379826  0.92
1990 Martinerie C, Cannizzaro LA, Croce CM, Huebner K, Katzav S, Barbacid M. The human VAV proto-oncogene maps to chromosome region 19p12----19p13.2. Human Genetics. 86: 65-8. PMID 2253939 DOI: 10.1007/BF00205175  0.92
1990 Manne V, Roberts D, Tobin A, O'Rourke E, De Virgilio M, Meyers C, Ahmed N, Kurz B, Resh M, Kung HF. Identification and preliminary characterization of protein-cysteine farnesyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 87: 7541-5. PMID 2217184  0.92
1990 Kumar R, Sukumar S, Barbacid M. Activation of ras oncogenes preceding the onset of neoplasia. Science (New York, N.Y.). 248: 1101-4. PMID 2188364  0.92
1990 Klein R, Martin-Zanca D, Barbacid M, Parada LF. Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development (Cambridge, England). 109: 845-50. PMID 2171894  0.92
1990 Klein R, Conway D, Parada LF, Barbacid M. The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell. 61: 647-56. PMID 2160854 DOI: 10.1016/0092-8674(90)90476-U  0.92
1990 Cuadrado A, Talbot N, Barbacid M. C127 cells resistant to transformation by tyrosine protein kinase oncogenes. Cell Growth & Differentiation : the Molecular Biology Journal of the American Association For Cancer Research. 1: 9-15. PMID 2150330  0.92
1990 Barbacid M. ras oncogenes: their role in neoplasia. European Journal of Clinical Investigation. 20: 225-35. PMID 2114981  0.92
1990 Coulier F, Kumar R, Ernst M, Klein R, Martin-Zanca D, Barbacid M. Human trk oncogenes activated by point mutation, in-frame deletion, and duplication of the tyrosine kinase domain. Molecular and Cellular Biology. 10: 4202-10. PMID 1695324  0.92
1990 Manne V, Roberts D, Tobin A, O'Rourke E, De Vlrgilio M, Meyers C, Ahmed N, Kurz B, Resh M, Kung HF, Barbacid M. Identification and preliminary characterization of protein-cysteine farnesyltransferase Proceedings of the National Academy of Sciences of the United States of America. 87: 7546-7550.  0.92
1989 Martin-Zanca D, Oskam R, Mitra G, Copeland T, Barbacid M. Molecular and biochemical characterization of the human trk proto-oncogene. Molecular and Cellular Biology. 9: 24-33. PMID 2927393  0.36
1989 Mitra G, Pauly GT, Kumar R, Pei GK, Hughes SH, Moschel RC, Barbacid M. Molecular analysis of O6-substituted guanine-induced mutagenesis of ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America. 86: 8650-4. PMID 2682655 DOI: 10.1073/pnas.86.22.8650  0.92
1989 Katzav S, Martin-Zanca D, Barbacid M, Hedge AM, Isfort R, Ihle JN. The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells. Oncogene. 4: 1129-35. PMID 2674855  0.92
1989 Klein R, Parada LF, Coulier F, Barbacid M. trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. The Embo Journal. 8: 3701-9. PMID 2555172  0.92
1989 Coulier F, Martin-Zanca D, Ernst M, Barbacid M. Mechanism of activation of the human trk oncogene. Molecular and Cellular Biology. 9: 15-23. PMID 2538716  0.92
1989 Katzav S, Martin-Zanca D, Barbacid M. vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells. The Embo Journal. 8: 2283-90. PMID 2477241  0.36
1989 Barbacid M. Oncogene file VAV Cancer Cells. 1: 130.  0.92
1988 Oskam R, Coulier F, Ernst M, Martin-Zanca D, Barbacid M. Frequent generation of oncogenes by in vitro recombination of TRK protooncogene sequences. Proceedings of the National Academy of Sciences of the United States of America. 85: 2964-8. PMID 3362859  0.36
1987 Mitra G, Martin-Zanca D, Barbacid M. Identification and biochemical characterization of p70TRK, product of the human TRK oncogene. Proceedings of the National Academy of Sciences of the United States of America. 84: 6707-11. PMID 3477801  0.36
1986 Martin-Zanca D, Mitra G, Long LK, Barbacid M. Molecular characterization of the human trk oncogene. Cold Spring Harbor Symposia On Quantitative Biology. 51: 983-92. PMID 3472772  0.36
1986 Zarbl H, Sukumar S, Arthur AL, Martin-Zanca D, Barbacid M. Activation of H-ras-1 oncogenes by chemical carcinogens. Basic Life Sciences. 38: 385-97. PMID 3017289  0.92
1986 Barbacid M, Sukumar S, Zarbl H. Activation of ras oncogenes by chemical carcinogens. Gene Amplification and Analysis. 4: 21-38. PMID 2906037  0.92
1986 Martin-Zanca D, Hughes SH, Barbacid M. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature. 319: 743-8. PMID 2869410 DOI: 10.1038/319743a0  0.36
1985 Zarbl H, Sukumar S, Arthur AV, Martin-Zanca D, Barbacid M. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats. Nature. 315: 382-5. PMID 3923365 DOI: 10.1038/315382a0  0.92
1985 Zarbl H, Sukumar S, Martin-Zanca D, Santos E, Barbacid M. Molecular assays for detection of ras oncogenes in human and animal tumors. Carcinogenesis; a Comprehensive Survey. 9: 1-16. PMID 3902219  0.92
1984 Santos E, Martin-Zanca D, Reddy EP, Pierotti MA, Della Porta G, Barbacid M. Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient. Science (New York, N.Y.). 223: 661-4. PMID 6695174  0.36
1984 Lacal JC, Santos E, Notario V, Barbacid M, Yamazaki S, Kung H, Seamans C, McAndrew S, Crowl R. Expression of normal and transforming H-ras genes in Escherichia coli and purification of their encoded p21 proteins. Proceedings of the National Academy of Sciences of the United States of America. 81: 5305-9. PMID 6089191  0.92
1983 Sukumar S, Notario V, Martin-Zanca D, Barbacid M. Induction of mammary carcinomas in rats by nitroso-methylurea involves malignant activation of H-ras-1 locus by single point mutations. Nature. 306: 658-61. PMID 6318112 DOI: 10.1038/306658a0  0.92
1983 Santos E, Reddy EP, Pulciani S, Feldmann RJ, Barbacid M. Spontaneous activation of a human proto-oncogene. Proceedings of the National Academy of Sciences of the United States of America. 80: 4679-83. PMID 6308640  0.92
1982 Reddy EP, Reynolds RK, Santos E, Barbacid M. A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature. 300: 149-52. PMID 7133135 DOI: 10.1038/300149a0  0.92
1982 Rasheed S, Barbacid M, Aaronson S, Gardner MB. Origin and biological properties of a new feline sarcoma virus. Virology. 117: 238-44. PMID 6175084 DOI: 10.1016/0042-6822(82)90522-0  0.92
1981 Aaronson SA, Barbacid M, Dunn CY, Reddy EP. Genetic approaches toward elucidating the mechanisms of type-C virus-induced leukemia. Haematology and Blood Transfusion. 26: 455-9. PMID 6274759  0.92
1980 Barbacid M, Beemon K, Devare SG. Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus. Proceedings of the National Academy of Sciences of the United States of America. 77: 5158-62. PMID 6254060  0.92
1980 Barbacid M, Bolognesi D, Aaronson SA. Humans have antibodies capable of recognizing oncoviral glycoproteins: demonstration that these antibodies are formed in response to cellular modification of glycoproteins rather than as consequence of exposure to virus. Proceedings of the National Academy of Sciences of the United States of America. 77: 1617-21. PMID 6154936  0.92
1978 Barbacid M, Aaronson SA. Membrane properties of the gag gene-coded p15 protein of mouse type-C RNA tumor viruses. The Journal of Biological Chemistry. 253: 1408-14. PMID 627545  0.92
1978 Aaronson SA, Barbacid M. Origin and biological properties of a new BALB/c mouse sarcoma virus. Journal of Virology. 27: 366-73. PMID 80461  0.92
1978 Barbacid M, Robbins KC, Hino S, Aaronson SA. Genetic recombination between mouse type C RNA viruses: a mechanism for endogenous viral gene amplification in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 923-7. PMID 76313  0.92
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