Lit-Fui Lau - Publications

Affiliations: 
Glaxo Smith Kline, Memphis, TN, United States 

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Toh JDW, Sun L, Lau LZM, Tan J, Low JJA, Tang CWQ, Cheong EJY, Tan MJH, Chen Y, Hong W, Gao YG, Woon ECY. A strategy based on nucleotide specificity leads to a subfamily-selective and cell-active inhibitor of N6-methyladenosine demethylase FTO Chemical Science. 6: 112-122. DOI: 10.1039/c4sc02554g  0.52
2013 Huang Y, Li T, Eatherton A, Mitchell WL, Rong N, Ye L, Yang XJ, Jin S, Ding Y, Zhang J, Li Y, Wu Y, Jin Y, Sang Y, Cheng Z, ... ... Lau LF, et al. Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo. Neuropharmacology. 70: 278-86. PMID 23485401 DOI: 10.1016/j.neuropharm.2013.02.003  1
2012 Li T, Huang Y, Jin S, Ye L, Rong N, Yang X, Ding Y, Cheng Z, Zhang J, Wan Z, Harrison DC, Hussain I, Hall A, Lee DH, Lau LF, et al. Γ-secretase modulators do not induce Aβ-rebound and accumulation of β-C-terminal fragment. Journal of Neurochemistry. 121: 277-86. PMID 22035227 DOI: 10.1111/j.1471-4159.2011.07560.x  1
2011 Wan Z, Hall A, Sang Y, Xiang JN, Yang E, Smith B, Harrison DC, Yang G, Yu H, Price HS, Wang J, Hawkins J, Lau LF, Johnson MR, Li T, et al. Pyridine-derived γ-secretase modulators. Bioorganic & Medicinal Chemistry Letters. 21: 4832-5. PMID 21742495 DOI: 10.1016/j.bmcl.2011.06.042  1
2011 Wan Z, Hall A, Jin Y, Xiang JN, Yang E, Eatherton A, Smith B, Yang G, Yu H, Wang J, Ye L, Lau LF, Yang T, Mitchell W, Cai W, et al. Pyridazine-derived γ-secretase modulators. Bioorganic & Medicinal Chemistry Letters. 21: 4016-9. PMID 21636276 DOI: 10.1016/j.bmcl.2011.04.143  1
2008 Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, et al. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 57: 680-90. PMID 18341989 DOI: 10.1016/j.neuron.2008.02.024  1
2008 Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE. Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2624-32. PMID 18322105 DOI: 10.1523/JNEUROSCI.5245-07.2008  1
2008 Lau LF, Hicks CD. Cdk5 as a drug target for alzheimer's disease Cyclin Dependent Kinase 5 (Cdk5). 283-299. DOI: 10.1007/978-0-387-78887-6_18  1
2007 Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE. Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3090-7. PMID 17376970 DOI: 10.1523/JNEUROSCI.4854-06.2007  1
2006 Lanz TA, Karmilowicz MJ, Wood KM, Pozdnyakov N, Du P, Piotrowski MA, Brown TM, Nolan CE, Richter KE, Finley JE, Fei Q, Ebbinghaus CF, Chen YL, Spracklin DK, Tate B, ... ... Lau LF, et al. Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139. The Journal of Pharmacology and Experimental Therapeutics. 319: 924-33. PMID 16920992 DOI: 10.1124/jpet.106.110700  1
2004 Chung HJ, Huang YH, Lau LF, Huganir RL. Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10248-59. PMID 15537897 DOI: 10.1523/JNEUROSCI.0546-04.2004  1
2004 Lau LF, Schachter JB. Animal models of tau phosphorylation and tauopathy - what have they taught us? Advances in Cell Aging and Gerontology. 16: 153-175. DOI: 10.1016/S1566-3124(04)16007-0  1
2003 Lau LF, Ahlijanian MK. Role of cdk5 in the pathogenesis of Alzheimer's disease. Neuro-Signals. 12: 209-14. PMID 14673207 DOI: 10.1159/000074622  1
2003 Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, ... ... Lau LF, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 38: 555-65. PMID 12765608 DOI: 10.1016/S0896-6273(03)00259-9  1
2002 Lau LF, Seymour PA, Sanner MA, Schachter JB. Cdk5 as a drug target for the treatment of Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 267-73. PMID 12540052 DOI: 10.1385/JMN:19:3:267  1
2002 Lau LF, Schachter JB, Seymour PA, Sanner MA. Tau protein phosphorylation as a therapeutic target in Alzheimer's disease. Current Topics in Medicinal Chemistry. 2: 395-415. PMID 11966463  1
2001 Ventimiglia R, Lau LF, Kinloch RA, Hopkins A, Karran EH, Petalidis LP, Ward RV. Role of caspases in neuronal apoptosis Drug Development Research. 52: 515-533. DOI: 10.1002/ddr.1155  1
1998 O'Brien RJ, Lau LF, Huganir RL. Molecular mechanisms of glutamate receptor clustering at excitatory synapses. Current Opinion in Neurobiology. 8: 364-9. PMID 9687358 DOI: 10.1016/S0959-4388(98)80062-7  1
1998 Kim JH, Liao D, Lau LF, Huganir RL. SynGAP: a synaptic RasGAP that associates with the PSD-95/SAP90 protein family. Neuron. 20: 683-91. PMID 9581761 DOI: 10.1016/S0896-6273(00)81008-9  1
1996 Ehlers MD, Mammen AL, Lau LF, Huganir RL. Synaptic targeting of glutamate receptors. Current Opinion in Cell Biology. 8: 484-9. PMID 8791455 DOI: 10.1016/S0955-0674(96)80024-X  1
1996 Müller BM, Kistner U, Kindler S, Chung WJ, Kuhlendahl S, Fenster SD, Lau LF, Veh RW, Huganir RL, Gundelfinger ED, Garner CC. SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron. 17: 255-65. PMID 8780649 DOI: 10.1016/S0896-6273(00)80157-9  1
1996 Lau LF, Mammen A, Ehlers MD, Kindler S, Chung WJ, Garner CC, Huganir RL. Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102. The Journal of Biological Chemistry. 271: 21622-8. PMID 8702950 DOI: 10.1074/jbc.271.35.21622  1
1995 Menegoz M, Lau LF, Hervé D, Huganir RL, Girault JA. Tyrosine phosphorylation of NMDA receptor in rat striatum: effects of 6-OH-dopamine lesions. Neuroreport. 7: 125-8. PMID 8742433 DOI: 10.1016/B978-0-12-374947-5.00026-2  1
1995 Lau LF, Huganir RL. Differential tyrosine phosphorylation of N-methyl-D-aspartate receptor subunits. The Journal of Biological Chemistry. 270: 20036-41. PMID 7544350 DOI: 10.1074/jbc.270.34.20036  1
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