Rikard Blunck, Ph.D. - Publications

Affiliations: 
2006- Physics Université de Montréal, Montréal, Canada 
Area:
Kv channels, pore forming toxins, iGluR, TRP, fluorescence, electrophysiology
Website:
http://www.biophys.umontreal.ca/bluncklab

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Bhat S, Rousseau J, Michaud C, Lourenço CM, Stoler JM, Louie RJ, Clarkson LK, Lichty A, Koboldt DC, Reshmi SC, Sisodiya SM, Hoytema van Konijnenburg EMM, Koop K, van Hasselt PM, Démurger F, ... ... Blunck R, et al. Mono-allelic KCNB2 variants lead to a neurodevelopmental syndrome caused by altered channel inactivation. American Journal of Human Genetics. PMID 38503299 DOI: 10.1016/j.ajhg.2024.02.014  0.393
2022 Bhat S, Blunck R. Characterising ion channel structure and dynamics using fluorescence spectroscopy techniques. Biochemical Society Transactions. 50: 1427-1445. PMID 36282004 DOI: 10.1042/BST20220605  0.446
2022 Dinoi G, Morin M, Conte E, Mor Shaked H, Coppola MA, D'Adamo MC, Elpeleg O, Liantonio A, Hartmann I, De Luca A, Blunck R, Russo A, Imbrici P. Clinical and Functional Study of a De Novo Variant in the PVP Motif of Kv1.1 Channel Associated with Epilepsy, Developmental Delay and Ataxia. International Journal of Molecular Sciences. 23. PMID 35897654 DOI: 10.3390/ijms23158079  0.407
2022 McGuire H, Blunck R. Studying KcsA Channel Clustering Using Single Channel Voltage-Clamp Fluorescence Imaging. Frontiers in Physiology. 13: 863375. PMID 35721536 DOI: 10.3389/fphys.2022.863375  0.687
2021 Imbrici P, Conte E, Blunck R, Stregapede F, Liantonio A, Tosi M, D'Adamo MC, De Luca A, Brankovic V, Zanni G. A Novel Variant in a Patient with Non-Progressive Congenital Ataxia and Epilepsy: Functional Characterization and Sensitivity to 4-Aminopyridine. International Journal of Molecular Sciences. 22. PMID 34576077 DOI: 10.3390/ijms22189913  0.412
2021 Blunck R. Determining stoichiometry of ion channel complexes using single subunit counting. Methods in Enzymology. 653: 377-404. PMID 34099180 DOI: 10.1016/bs.mie.2021.02.017  0.312
2021 Imbrici P, Accogli A, Blunck R, Altamura C, Iacomino M, D'adamo MC, Allegri A, Pedemonte M, Brolatti N, Vari S, Cataldi M, Capra V, Gustincich S, Zara F, Desaphy JF, et al. Musculoskeletal Features without Ataxia Associated with a Novel de novo Mutation in Impairing the Voltage Sensitivity of Kv1.1 Channel. Biomedicines. 9. PMID 33466780 DOI: 10.3390/biomedicines9010075  0.403
2020 Zhao J, Petitjean D, Haddad GA, Batulan Z, Blunck R. A Common Kinetic Property of Mutations Linked to Episodic Ataxia Type 1 Studied in the Shaker Kv Channel. International Journal of Molecular Sciences. 21. PMID 33066705 DOI: 10.3390/ijms21207602  0.819
2020 Möller L, Regnier G, Labro AJ, Blunck R, Snyders DJ. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. Proceedings of the National Academy of Sciences of the United States of America. PMID 32284408 DOI: 10.1073/Pnas.1916166117  0.523
2020 Beaulieu-Laroche L, Christin M, Donoghue A, Agosti F, Yousefpour N, Petitjean H, Davidova A, Stanton C, Khan U, Dietz C, Faure E, Fatima T, MacPherson A, Mouchbahani-Constance S, Bisson DG, ... ... Blunck R, et al. TACAN Is an Ion Channel Involved in Sensing Mechanical Pain. Cell. PMID 32084332 DOI: 10.1016/J.Cell.2020.01.033  0.793
2020 Pandey R, Kalstrup TU, Blunck R. Position of Inactivation Particle of Shaker Kv Channels in Resting State Biophysical Journal. 118: 169a. DOI: 10.1016/J.Bpj.2019.11.1035  0.804
2019 Lussier Y, Fürst O, Fortea E, Leclerc M, Priolo D, Moeller L, Bichet DG, Blunck R, D'Avanzo N. Disease-linked mutations alter the stoichiometries of HCN-KCNE2 complexes. Scientific Reports. 9: 9113. PMID 31235733 DOI: 10.1038/S41598-019-45592-3  0.417
2019 Zhao J, Blunck R. Single Channel Studies of the Cation Permeation Pathway of the Shaker Kv Isolated Voltage-Sensing Domain (iVSD) Biophysical Journal. 116: 543a. DOI: 10.1016/J.Bpj.2018.11.2917  0.602
2018 Kalstrup T, Blunck R. S4-S5 linker movement during activation and inactivation in voltage-gated K channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 29959207 DOI: 10.1073/Pnas.1719105115  0.829
2018 Lussier Y, Callahan K, Blunck R, D'Avanzo N. Molecular Interactions that Contribute to the Regulation of HCN Channels by KCNE2 Biophysical Journal. 114: 120a. DOI: 10.1016/J.Bpj.2017.11.688  0.466
2018 Zhao J, Blunck R. Mode Shift of Shaker Isolated-Voltage Sensing Domain Biophysical Journal. 114: 546a. DOI: 10.1016/J.Bpj.2017.11.2982  0.437
2017 Liebsch F, Aurousseau MRP, Bethge T, McGuire H, Scolari S, Herrmann A, Blunck R, Bowie D, Multhaup G. Full-length Cellular Beta-secretase Has a Trimeric Subunit Stoichiometry, and Its Sulfur-rich Transmembrane Interaction Site Modulates Cytosolic Copper Compartmentalization. The Journal of Biological Chemistry. PMID 28637867 DOI: 10.1074/Jbc.M117.779165  0.751
2017 Kalstrup T, Blunck R. Voltage-clamp Fluorometry in Xenopus Oocytes Using Fluorescent Unnatural Amino Acids. Journal of Visualized Experiments : Jove. PMID 28605379 DOI: 10.3791/55598  0.794
2017 Kalstrup T, Pandey R, Blunck R. Probing the Movement of the Ball and Chain during N-type Inactivation in Kv Channels Biophysical Journal. 112: 39a. DOI: 10.1016/J.Bpj.2016.11.247  0.807
2017 Zhao J, Blunck R. The Isolated Voltage Sensing Domain of the Shaker Potassium Channel forms a Cation Channel Biophysical Journal. 112: 249a. DOI: 10.1016/J.Bpj.2016.11.1361  0.622
2017 Sharmin N, Mohler P, Blunck R, Nattel S. Molecular Interactions between Kv4.3 and DPP6 - The Biochemical Anatomy of Idiopathic Ventricular Fibrillation Biophysical Journal. 112: 183a. DOI: 10.1016/J.Bpj.2016.11.1016  0.352
2017 Lussier Y, Möller L, Fürst O, Blunck R, D'Avanzo N. Stoichiometries of HCN-KCNE2 Channel Biophysical Journal. 112: 183a. DOI: 10.1016/J.Bpj.2016.11.1015  0.53
2016 Zhao J, Blunck R. The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel. Elife. 5. PMID 27710769 DOI: 10.7554/Elife.18130  0.626
2016 Sasseville LJ, Morin M, Coady MJ, Blunck R, Lapointe JY. The Human Sodium-Glucose Cotransporter (hSGLT1) Is a Disulfide-Bridged Homodimer with a Re-Entrant C-Terminal Loop. Plos One. 11: e0154589. PMID 27137918 DOI: 10.1371/Journal.Pone.0154589  0.433
2016 Zhao J, Blunck R. Author response: The isolated voltage sensing domain of the Shaker potassium channel forms a voltage-gated cation channel Elife. DOI: 10.7554/Elife.18130.010  0.629
2016 Kalstrup T, Blunck R. Probing the S4-S5 Linker Movement During Activation in KV Channels Biophysical Journal. 110: 104a. DOI: 10.1016/J.Bpj.2015.11.617  0.83
2016 Aurousseau MRP, McGuire H, Blunck R, Bowie D. A step-by-step guide to single-subunit counting of membrane-bound proteins in mammalian cells Neuromethods. 106: 15-30. DOI: 10.1007/978-1-4939-2812-5_2  0.751
2015 Petitjean D, Kalstrup T, Zhao J, Blunck R. A Disease Mutation Causing Episodic Ataxia Type I in the S1 Links Directly to the Voltage Sensor and the Selectivity Filter in Kv Channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12198-206. PMID 26338330 DOI: 10.1523/Jneurosci.1419-15.2015  0.818
2015 Kalstrup T, Blunck R. Reinitiation at non-canonical start codons leads to leak expression when incorporating unnatural amino acids. Scientific Reports. 5: 11866. PMID 26153354 DOI: 10.1038/Srep11866  0.777
2015 Kalstrup T, Blunck R. Non-Canonical Start Codons Reinitiate Translation in N-Terminal Truncated Kv Channels Biophysical Journal. 108: 118a. DOI: 10.1016/J.Bpj.2014.11.661  0.817
2015 McGuire H, Blunck R. Studying Clustering of KcsA Channels using Single-Channel Voltage-Clamp Fluorescence Imaging Biophysical Journal. 108: 440a. DOI: 10.1016/J.Bpj.2014.11.2404  0.729
2015 Zhao J, Blunck R. Role of the Voltage Sensing Domain S1-S4 in TRPV1 Channels Biophysical Journal. 108: 427a. DOI: 10.1016/J.Bpj.2014.11.2337  0.638
2015 Petitjean D, Blunck R. A Point Mutation Causing Episodic Ataxia Reveals Functional Link between Voltage Sensor and Selectivity Filter in Shaker Kv Channels Biophysical Journal. 108: 24a. DOI: 10.1016/J.Bpj.2014.11.154  0.745
2014 Faure É, Thompson C, Blunck R. Do lipids show state-dependent affinity to the voltage-gated potassium channel KvAP? The Journal of Biological Chemistry. 289: 16452-61. PMID 24742679 DOI: 10.1074/Jbc.M113.537134  0.539
2014 McGuire H, Blunck R. Influence of Lipid Bilayer Thickness on Ion Channels Using Single-Channel Voltage-Clamp Fluorescence Imaging Biophysical Journal. 106: 738a-739a. DOI: 10.1016/J.Bpj.2013.11.4070  0.74
2014 Kalstrup T, Blunck R. Cytosolic Activation Dynamics in the KV Channel Probed by a Fluorescent Unnatural Amino Acid Biophysical Journal. 106: 536a-537a. DOI: 10.1016/J.Bpj.2013.11.2992  0.849
2014 Bhattacharyya I, Blunck R. Occupancy of a Single Binding Site is Sufficient for AMPAR Activation Biophysical Journal. 106: 30a. DOI: 10.1016/J.Bpj.2013.11.218  0.444
2014 Faure E, Thompson C, Blunck R. Lipid Affinity to the Voltage-Gated Potassium Channel KvAP Biophysical Journal. 106: 15a-16a. DOI: 10.1016/J.Bpj.2013.11.139  0.835
2013 Kalstrup T, Blunck R. Dynamics of internal pore opening in K(V) channels probed by a fluorescent unnatural amino acid. Proceedings of the National Academy of Sciences of the United States of America. 110: 8272-7. PMID 23630265 DOI: 10.1073/Pnas.1220398110  0.837
2013 Starek G, Faure É, McGuire H, Blunck R, Bernèche S. A Molecular Mechanics Model of a Closed Voltage-Gated Potassium Channel Generated from S4-S5 Linker LRET Measurements Biophysical Journal. 104: 124a. DOI: 10.1016/J.Bpj.2012.11.716  0.845
2013 Sasseville LJ, Coady MJ, Blunck R, Lapointe J. FRET Quenching by a Hybrid Voltage Sensor (Hvos) Reveals that the Na/Glucose Cotransporter (SGLT1) Is a Disulfide-Bridged Homodimer with Re-Entrant 12-13 Loop Biophysical Journal. 104: 223a. DOI: 10.1016/J.Bpj.2012.11.1256  0.371
2012 Faure É, Starek G, McGuire H, Bernèche S, Blunck R. A limited 4 Ã… radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels. The Journal of Biological Chemistry. 287: 40091-8. PMID 23019337 DOI: 10.1074/Jbc.M112.415497  0.754
2012 Blunck R, Batulan Z. Mechanism of electromechanical coupling in voltage-gated potassium channels. Frontiers in Pharmacology. 3: 166. PMID 22988442 DOI: 10.3389/Fphar.2012.00166  0.847
2012 McGuire H, Aurousseau MR, Bowie D, Blunck R. Automating single subunit counting of membrane proteins in mammalian cells. The Journal of Biological Chemistry. 287: 35912-21. PMID 22930752 DOI: 10.1074/Jbc.M112.402057  0.772
2012 McGuire H, Aurousseau M, Bowie D, Blunck R. An Automated Method to Study Oligomerization of Single Membrane-Bound Proteins using Fluorescence Imaging Biophysical Journal. 102: 114a-115a. DOI: 10.1016/J.Bpj.2011.11.644  0.767
2012 Brown P, Aurousseau M, McGuire H, Blunck R, Bowie D. Gating and Stoichiometry of Heteromeric Kainate Receptors Biophysical Journal. 102: 613a. DOI: 10.1016/J.Bpj.2011.11.3342  0.764
2012 McGuire H, Groulx N, Laprade R, Schwartz J, Blunck R. Single Molecule Fluorescence Study of the B. Thuringiensis Toxin Cry1Aa Reveals Tetramerization Biophysical Journal. 102: 214a. DOI: 10.1016/J.Bpj.2011.11.1170  0.801
2012 Faure E, McGuire H, Marsolais M, Blunck R. Movement of the S4-S5 Linker of KvAP during Gating Biophysical Journal. 102: 13a. DOI: 10.1016/J.Bpj.2011.11.097  0.839
2011 Groulx N, McGuire H, Laprade R, Schwartz JL, Blunck R. Single molecule fluorescence study of the Bacillus thuringiensis toxin Cry1Aa reveals tetramerization. The Journal of Biological Chemistry. 286: 42274-82. PMID 22006922 DOI: 10.1074/Jbc.M111.296103  0.807
2011 Wall-Lacelle S, Hossain MI, Sauvé R, Blunck R, Parent L. Double mutant cycle analysis identified a critical leucine residue in the IIS4S5 linker for the activation of the Ca(V)2.3 calcium channel. The Journal of Biological Chemistry. 286: 27197-205. PMID 21652722 DOI: 10.1074/Jbc.M111.237412  0.463
2011 Haddad GA, Blunck R. Mode shift of the voltage sensors in Shaker K+ channels is caused by energetic coupling to the pore domain. The Journal of General Physiology. 137: 455-72. PMID 21518834 DOI: 10.1085/Jgp.201010573  0.74
2010 Groulx N, Juteau M, Blunck R. Rapid topology probing using fluorescence spectroscopy in planar lipid bilayer: the pore-forming mechanism of the toxin Cry1Aa of Bacillus thuringiensis. The Journal of General Physiology. 136: 497-513. PMID 20974771 DOI: 10.1085/Jgp.200910347  0.784
2010 Batulan Z, Haddad GA, Blunck R. An intersubunit interaction between S4-S5 linker and S6 is responsible for the slow off-gating component in Shaker K+ channels. The Journal of Biological Chemistry. 285: 14005-19. PMID 20202932 DOI: 10.1074/Jbc.M109.097717  0.843
2010 McGuire H, Blunck R. Towards Simultaneous Single Channel Current and Fluorescence Recordings in Planar Lipid Bilayer Biophysical Journal. 98: 536a-537a. DOI: 10.1016/J.Bpj.2009.12.2911  0.756
2010 Batulan Z, Haddad GA, Blunck R. Molecular Determinants of the Slow Off-Gating Component in Shaker K+ Channels Biophysical Journal. 98: 522a. DOI: 10.1016/J.Bpj.2009.12.2838  0.833
2009 McGuire H, Blunck R. [Single-channel fluorescence spectroscopy to study conformational changes of ion channels]. Mã©Decine Sciences : M/S. 25: 951-4. PMID 19951670 DOI: 10.1051/Medsci/20092511951  0.555
2009 Groulx N, Juteau M, Schwartz J, Laprade R, Blunck R. Rapid Topology Determination of Membrane Proteins: Pore-Forming Mechanism of Bt toxin Cry1Aa Biophysical Journal. 96: 535a. DOI: 10.1016/J.Bpj.2008.12.2761  0.77
2009 Batulan Z, Haddad GA, Marsolais M, Blunck R. Investigating the Electromechanical Coupling in voltage-gated K+ channels Biophysical Journal. 96: 369a. DOI: 10.1016/J.Bpj.2008.12.1990  0.845
2009 McGuire H, Bezanilla F, Blunck R. Determining The Coupling Between Subunits In Kcsa Using Single Channel Fluorescence Spectroscopy Biophysical Journal. 96: 24a. DOI: 10.1016/J.Bpj.2008.12.1024  0.793
2008 Blunck R, McGuire H, Hyde HC, Bezanilla F. Fluorescence detection of the movement of single KcsA subunits reveals cooperativity. Proceedings of the National Academy of Sciences of the United States of America. 105: 20263-8. PMID 19074286 DOI: 10.1073/Pnas.0807056106  0.844
2006 Richardson J, Blunck R, Ge P, Selvin PR, Bezanilla F, Papazian DM, Correa AM. Distance measurements reveal a common topology of prokaryotic voltage-gated ion channels in the lipid bilayer. Proceedings of the National Academy of Sciences of the United States of America. 103: 15865-70. PMID 17043236 DOI: 10.1073/Pnas.0607532103  0.673
2006 Blunck R, Cordero-Morales JF, Cuello LG, Perozo E, Bezanilla F. Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. The Journal of General Physiology. 128: 569-81. PMID 17043150 DOI: 10.1085/Jgp.200609638  0.769
2006 Scheel O, Papavlassopoulos M, Blunck R, Gebert A, Hartung T, Zähringer U, Seydel U, Schromm AB. Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages. Infection and Immunity. 74: 4354-6. PMID 16790810 DOI: 10.1128/Iai.01783-05  0.606
2005 Blunck R, Chanda B, Bezanilla F. Nano to micro -- fluorescence measurements of electric fields in molecules and genetically specified neurons. The Journal of Membrane Biology. 208: 91-102. PMID 16645739 DOI: 10.1007/S00232-005-0822-Z  0.705
2005 Chanda B, Blunck R, Faria LC, Schweizer FE, Mody I, Bezanilla F. A hybrid approach to measuring electrical activity in genetically specified neurons. Nature Neuroscience. 8: 1619-26. PMID 16205716 DOI: 10.1038/Nn1558  0.684
2005 Chanda B, Asamoah OK, Blunck R, Roux B, Bezanilla F. Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature. 436: 852-6. PMID 16094369 DOI: 10.1038/Nature03888  0.833
2004 Pantoja R, Nagarah JM, Starace DM, Melosh NA, Blunck R, Bezanilla F, Heath JR. Silicon chip-based patch-clamp electrodes integrated with PDMS microfluidics. Biosensors & Bioelectronics. 20: 509-17. PMID 15494233 DOI: 10.1016/J.Bios.2004.02.020  0.588
2004 Blunck R, Starace DM, Correa AM, Bezanilla F. Detecting rearrangements of shaker and NaChBac in real-time with fluorescence spectroscopy in patch-clamped mammalian cells. Biophysical Journal. 86: 3966-80. PMID 15189893 DOI: 10.1529/Biophysj.103.034512  0.676
2004 Ries RS, Choi H, Blunck R, Bezanilla F, Heath JR. Black lipid membranes: Visualizing the structure, dynamics, and substrate dependence of membranes Journal of Physical Chemistry B. 108: 16040-16049. DOI: 10.1021/Jp048098H  0.572
2002 Scheel O, Seydel U, Blunck R. Effects of Hydrophobic Channel Modulators on Membrane Fluidity and Single Channel Kinetics of MaxiK Channels Anesthesiology. 96: A826. DOI: 10.1097/00000542-200209002-00826  0.697
2001 Seydel U, Scheel O, Müller M, Brandenburg K, Blunck R. A K+ channel is involved in LPS signaling. Journal of Endotoxin Research. 7: 243-7. PMID 11581578 DOI: 10.1177/09680519010070030901  0.654
2001 Pantoja R, Sigg D, Blunck R, Bezanilla F, Heath JR. Bilayer reconstitution of voltage-dependent ion channels using a microfabricated silicon chip. Biophysical Journal. 81: 2389-94. PMID 11566808 DOI: 10.1016/S0006-3495(01)75885-7  0.672
2001 Blunck R, Scheel O, Müller M, Brandenburg K, Seitzer U, Seydel U. New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling. Journal of Immunology (Baltimore, Md. : 1950). 166: 1009-15. PMID 11145680 DOI: 10.4049/Jimmunol.166.2.1009  0.634
2000 Seydel U, Schromm AB, Blunck R, Brandenburg K. Chemical structure, molecular conformation, and bioactivity of endotoxins. Chemical Immunology. 74: 5-24. PMID 10608079 DOI: 10.1159/000058754  0.516
1999 Schromm AB, Brandenburg K, Blunck R, Fukase K, Kusumoto S, Rietschel ET, Seydel U. A biophysical approach towards an understanding of endotoxin-induced signal transduction Innate Immunity. 5: 41-45. DOI: 10.1177/09680519990050011901  0.629
1998 Blunck R, Kirst U, Riessner T, Hansen U. How powerful is the dwell-time analysis of multichannel records? The Journal of Membrane Biology. 165: 19-35. PMID 9705979 DOI: 10.1007/S002329900417  0.67
1997 Hansen UP, Keunecke M, Blunck R. Gating and permeation models of plant channels. Journal of Experimental Botany. 48: 365-82. PMID 21245216 DOI: 10.1093/Jxb/48.Special_Issue.365  0.622
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