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Relja Popovic, Ph.D. - Publications

Affiliations: 
2008 Loyola University Chicago, Chicago, IL, United States 
Area:
Molecular Biology
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Cojocari D, Jin S, Purkal JJ, Popovic R, Talaty NN, Xiao Y, Solomon LR, Boghaert E, Leverson JD, Phillips DC. 5-Azacytidine Induces NOXA and PUMA Expression to Prime AML Cells for Venetoclax-Mediated Apoptosis Blood. 132: 2644-2644. DOI: 10.1182/Blood-2018-99-111985  0.304
2017 Ezponda T, Dupéré-Richer D, Will CM, Small EC, Varghese N, Patel T, Nabet B, Popovic R, Oyer J, Bulic M, Zheng Y, Huang X, Shah MY, Maji S, Riva A, et al. UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition. Cell Reports. 21: 628-640. PMID 29045832 DOI: 10.1016/J.Celrep.2017.09.078  0.459
2017 Bellin RJ, Hilgenberg V, Popovic R, Uziel T, Lam LT. Abstract 3812:JAK2andPTPN11mutations as potential biomarkers for BCL-xL inhibition as monotherapy and in combination therapy for acute myeloid leukemia Cancer Research. 77: 3812-3812. DOI: 10.1158/1538-7445.Am2017-3812  0.384
2016 Shah MY, Martinez-Garcia E, Phillip JM, Chambliss AB, Popovic R, Ezponda T, Small EC, Will C, Phillip MP, Neri P, Bahlis NJ, Wirtz D, Licht JD. MMSET/WHSC1 enhances DNA damage repair leading to an increase in resistance to chemotherapeutic agents. Oncogene. PMID 27109101 DOI: 10.1038/Onc.2016.116  0.486
2015 Nabet B, Ó Broin P, Reyes JM, Shieh K, Lin CY, Will CM, Popovic R, Ezponda T, Bradner JE, Golden AA, Licht JD. Deregulation of the Ras-Erk Signaling Axis Modulates the Enhancer Landscape. Cell Reports. 12: 1300-13. PMID 26279576 DOI: 10.1016/J.Celrep.2015.06.078  0.4
2015 Kumar K, Raza SS, Knab LM, Chow CR, Kwok B, Bentrem DJ, Popovic R, Ebine K, Licht JD, Munshi HG. GLI2-dependent c-MYC upregulation mediates resistance of pancreatic cancer cells to the BET bromodomain inhibitor JQ1. Scientific Reports. 5: 9489. PMID 25807524 DOI: 10.1038/Srep09489  0.335
2015 Zhou Z, Gao J, Popovic R, Wolniak K, Parimi V, Winter JN, Licht JD, Chen YH. Strong expression of EZH2 and accumulation of trimethylated H3K27 in diffuse large B-cell lymphoma independent of cell of origin and EZH2 codon 641 mutation. Leukemia & Lymphoma. 1-7. PMID 25651430 DOI: 10.3109/10428194.2015.1006220  0.379
2015 Oyer J, Will C, Huang X, Ezponda T, Popovic R, Zheng Y, Kelleher NL, Licht JD. Allele-Specific Crispr Targeting Reveals Epigenetic and Phenotypic Effects of a MMSET Gain of Function Mutation Found in Relapsed Acute Lymphoblastic Leukemia Blood. 126: 437-437. DOI: 10.1182/Blood.V126.23.437.437  0.482
2015 Ezponda T, Popovic R, Zheng Y, Nabet B, Will C, Small E, Occhionorelli M, Tonon G, Keats J, Kelleher N, Licht JD. Abstract B32: Loss of the histone demethylase UTX alters the gene expression prolife and contributes to the malignant phenotype of multiple myeloma cells. Clinical Cancer Research. 21. DOI: 10.1158/1557-3265.Hemmal14-B32  0.507
2015 Nabet B, Broin PO, Reyes J, Shieh K, Lin CY, Will CM, Popovic R, Ezponda T, Bradner JE, Golden AA, Licht JD. Abstract 2209: Deregulation of the Ras-Erk signaling axis modulates the enhancer landscape Cancer Research. 75: 2209-2209. DOI: 10.1158/1538-7445.Am2015-2209  0.421
2014 Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC, Hua Y, Bulic M, Jiang Y, Carrara M, Calogero RA, et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. Plos Genetics. 10: e1004566. PMID 25188243 DOI: 10.1371/Journal.Pgen.1004566  0.534
2014 Oyer JA, Huang X, Zheng Y, Shim J, Ezponda T, Carpenter Z, Allegretta M, Okot-Kotber CI, Patel JP, Melnick A, Levine RL, Ferrando A, Mackerell AD, Kelleher NL, Licht JD, ... Popovic R, et al. Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies. Leukemia. 28: 198-201. PMID 23823660 DOI: 10.1038/Leu.2013.204  0.388
2014 Ezponda T, Popovic R, Zheng Y, Nabet B, Will C, Small EC, Occhionorelli M, Tonon G, Keats JJ, Kelleher NL, Licht JD. Loss of the Histone Demethylase UTX Contributes to Multiple Myeloma and Sensitizes Cells to EZH2 Inhibitors Blood. 124: 611-611. DOI: 10.1182/Blood.V124.21.611.611  0.482
2014 Beguelin W, Teater M, Popovic R, Jiang Y, Cerchietti L, Shaknovich R, Gascoyne R, Levine R, Abdel-Wahab O, Licht J, Elemento O, Melnick AM. Abstract SY09-03: How deregulation of histone methyltransferases drive malignant transformation of B-cells Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy09-03  0.494
2013 Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SN, Wang L, Ezponda T, Martinez-Garcia E, Zhang H, Zheng Y, Verma SK, McCabe MT, et al. EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation. Cancer Cell. 23: 677-92. PMID 23680150 DOI: 10.1016/J.Ccr.2013.04.011  0.446
2013 Popovic R, Shah MY, Licht JD. Epigenetic therapy of hematological malignancies: where are we now? Therapeutic Advances in Hematology. 4: 81-91. PMID 23610616 DOI: 10.1177/2040620712466864  0.456
2013 Min DJ, Ezponda T, Kim MK, Will CM, Martinez-Garcia E, Popovic R, Basrur V, Elenitoba-Johnson KS, Licht JD. MMSET stimulates myeloma cell growth through microRNA-mediated modulation of c-MYC Leukemia. 27: 686-694. PMID 22972034 DOI: 10.1182/Blood.V118.21.469.469  0.379
2013 Ezponda T, Popovic R, Shah MY, Martinez-Garcia E, Zheng Y, Min DJ, Will C, Neri A, Kelleher NL, Yu J, Licht JD. The histone methyltransferase MMSET/WHSC1 activates TWIST1 to promote an epithelial-mesenchymal transition and invasive properties of prostate cancer. Oncogene. 32: 2882-90. PMID 22797064 DOI: 10.1038/Onc.2012.297  0.445
2013 Popovic R, Martinez-Garcia E, Zhang Q, Ezponda T, Shah MY, Zhang Y, Jiang Y, Will CM, Small EC, Bulic M, Elemento O, Kelleher N, Kath W, Wang J, Licht JD. MMSET dysregulates gene expression in myeloma through global and focal changes in H3K36 and H3K27 methylation Epigenetics & Chromatin. 6. DOI: 10.1186/1756-8935-6-S1-P66  0.578
2013 Small EC, Zhang Q, Popovic R, Hua Y, Wang J, Licht JD. Genome-wide nucleosome mapping in multiple myeloma Epigenetics & Chromatin. 6. DOI: 10.1186/1756-8935-6-S1-P124  0.509
2013 Shah MY, Martinez E, Popovic R, Ezponda T, Small EC, Will C, Neri P, Bahlis NJ, Licht JD. MMSET/WHSC1 Enhances DNA Damage Repair Leading To An Increase In Resistance To Chemotherapeutic Agents Blood. 122: 808-808. DOI: 10.1182/Blood.V122.21.808.808  0.491
2013 Nabet B, Braun R, Popovic R, Licht JD. Abstract 740: Investigating the role of epigenetic mechanisms upon aberrant signaling network activation. Cancer Research. 73: 740-740. DOI: 10.1158/1538-7445.Am2013-740  0.416
2013 Will C, Scholle M, Pierre RS, Shim JH, Cheng ZJ, Popovic R, Patel DJ, Bradner JE, MacKerell AD, Mrksich M, Licht JD. Abstract 1127: MMSET: Can we flip the switch. Cancer Research. 73: 1127-1127. DOI: 10.1158/1538-7445.Am2013-1127  0.504
2012 Zheng Y, Sweet SM, Popovic R, Martinez-Garcia E, Tipton JD, Thomas PM, Licht JD, Kelleher NL. Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3. Proceedings of the National Academy of Sciences of the United States of America. 109: 13549-54. PMID 22869745 DOI: 10.1073/Pnas.1205707109  0.408
2012 Popovic R, Licht JD. Emerging epigenetic targets and therapies in cancer medicine. Cancer Discovery. 2: 405-13. PMID 22588878 DOI: 10.1158/2159-8290.Cd-12-0076  0.437
2012 Popovic R, Martinez E, Zhang Q, Ezponda T, Jiang Y, Shah MY, Will C, Small EC, Elemento O, Wang J, Licht JD. MMSET Dysregulates Gene Expression in Myeloma Through Global and Focal Changes in H3K36 and H3K27 Methylation Blood. 120: 523-523. DOI: 10.1182/Blood.V120.21.523.523  0.593
2012 Ezponda-Itoiz T, Popovic R, Shah MY, Martinez-Garcia E, Min D, Will C, Licht JD. Abstract 1046: The histone methyl transferase MMSET/WHSC1 promotes an epithelial-mesenchymal transition and invasive properties of prostate cancer Cancer Research. 72: 1046-1046. DOI: 10.1158/1538-7445.Am2012-1046  0.459
2011 Martinez-Garcia E, Popovic R, Min DJ, Sweet SM, Thomas PM, Zamdborg L, Heffner A, Will C, Lamy L, Staudt LM, Levens DL, Kelleher NL, Licht JD. The MMSET histone methyl transferase switches global histone methylation and alters gene expression in t(4;14) multiple myeloma cells. Blood. 117: 211-20. PMID 20974671 DOI: 10.1182/Blood-2010-07-298349  0.501
2011 Popovic R, Martinez-Garcia E, Sweet SM, Zheng Y, Kelleher NL, Licht JD. MMSET Contributes to Multiple Myeloma Oncogenesis Through Induction of Global Epigenetic Changes and Alteration of the DNA Damage Response, Blood. 118: 3475-3475. DOI: 10.1182/Blood.V118.21.3475.3475  0.605
2011 Licht JD, Popovic R, Min D, Martinez-Garcia E, Mrksch M, Kelleher N, Will C, Ezponda T. Abstract PL05-02: MMSET: A pathogenic factor and therapeutic target in multiple myeloma. Molecular Cancer Therapeutics. 10. DOI: 10.1158/1535-7163.Targ-11-Pl05-02  0.586
2010 Cierpicki T, Risner LE, Grembecka J, Lukasik SM, Popovic R, Omonkowska M, Shultis DD, Zeleznik-Le NJ, Bushweller JH. Structure of the MLL CXXC domain-DNA complex and its functional role in MLL-AF9 leukemia. Nature Structural & Molecular Biology. 17: 62-8. PMID 20010842 DOI: 10.1038/Nsmb.1714  0.721
2009 Popovic R, Riesbeck LE, Velu CS, Chaubey A, Zhang J, Achille NJ, Erfurth FE, Eaton K, Lu J, Grimes HL, Chen J, Rowley JD, Zeleznik-Le NJ. Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization. Blood. 113: 3314-22. PMID 19188669 DOI: 10.1182/Blood-2008-04-154310  0.61
2009 Risner L, Cierpicki T, Grembecka J, Lukasik SM, Popovic R, Shultis DS, Zeleznik-Le NJ, Bushweller JH. Structural Basis for MLL Cxxc Domain Protection against CpG DNA Methylation and the Essential Role of This Function in MLL-AF9 Leukemia. Blood. 114: 763-763. DOI: 10.1182/Blood.V114.22.763.763  0.716
2009 Martinez-Garcia E, Popovic R, Min D, Will C, Meyer J, Staudt LM, Lamy L, Lauring J, Cheng Z, Patel D, Licht JD. The MMSET Histone Methyl Transferase Alters Chromatin Structure and Gene Expression in t(4;14) Multiple Myeloma Cells. Blood. 114: 675-675. DOI: 10.1182/Blood.V114.22.675.675  0.558
2008 Erfurth FE, Popovic R, Grembecka J, Cierpicki T, Theisler C, Xia ZB, Stuart T, Diaz MO, Bushweller JH, Zeleznik-Le NJ. MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression. Proceedings of the National Academy of Sciences of the United States of America. 105: 7517-22. PMID 18483194 DOI: 10.1073/Pnas.0800090105  0.737
2008 Popovic R, Erfurth F, Zeleznik-Le N. Transcriptional complexity of the HOXA9 locus. Blood Cells, Molecules & Diseases. 40: 156-9. PMID 17916434 DOI: 10.1016/J.Bcmd.2007.07.016  0.649
2006 Santillan DA, Theisler CM, Ryan AS, Popovic R, Stuart T, Zhou MM, Alkan S, Zeleznik-Le NJ. Bromodomain and histone acetyltransferase domain specificities control mixed lineage leukemia phenotype. Cancer Research. 66: 10032-9. PMID 17047066 DOI: 10.1158/0008-5472.Can-06-2597  0.735
2005 Xia ZB, Popovic R, Chen J, Theisler C, Stuart T, Santillan DA, Erfurth F, Diaz MO, Zeleznik-Le NJ. The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression. Proceedings of the National Academy of Sciences of the United States of America. 102: 14028-33. PMID 16169901 DOI: 10.1073/Pnas.0506464102  0.744
2005 Popovic R, Zeleznik-Le NJ. MLL: how complex does it get? Journal of Cellular Biochemistry. 95: 234-42. PMID 15779005 DOI: 10.1002/Jcb.20430  0.673
2004 Xia Z, Popovic R, Lorenz T, Santillan D, Erfurth F, Zeleznik-Le NJ. MLL-AF4 Down-Regulates CDKN1B (P27) Independent of Cell Cycle Progression. Blood. 104: 2563-2563. DOI: 10.1182/Blood.V104.11.2563.2563  0.74
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