272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Scheetz L, Park KS, Li Q, Lowenstein PR, Castro MG, Schwendeman A, Moon JJ. Engineering patient-specific cancer immunotherapies. Nature Biomedical Engineering. PMID 31406259 DOI: 10.1038/s41551-019-0436-x  1
2019 Núñez FJ, Mendez FM, Kadiyala P, Alghamri MS, Savelieff MG, Garcia-Fabiani MB, Haase S, Koschmann C, Calinescu AA, Kamran N, Saxena M, Patel R, Carney S, Guo MZ, Edwards M, ... ... Lowenstein PR, et al. IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage response. Science Translational Medicine. 11. PMID 30760578 DOI: 10.1126/scitranslmed.aaq1427  1
2019 Kadiyala P, Li D, Nunez FM, Altshuler D, Doherty R, Kuai R, Yu M, Kamran N, Edwards M, Moon JJ, Lowenstein PR, Castro MG, Schwendeman A. High Density Lipoprotein-Mimicking Nanodiscs for Chemo-Immunotherapy against Glioblastoma Multiforme. Acs Nano. PMID 30721028 DOI: 10.1021/acsnano.8b06842  1
2019 Núñez FJ, Mendez FM, Garcia-Fabiani MB, Pardo J, Edwards M, Lowenstein PR, Castro MG. Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures. Journal of Visualized Experiments : Jove. PMID 30688315 DOI: 10.3791/58931  1
2018 Haase S, Garcia-Fabiani MB, Carney S, Altshuler D, Núñez FJ, Méndez FM, Núñez F, Lowenstein PR, Castro MG. Mutant ATRX: uncovering a new therapeutic target for glioma. Expert Opinion On Therapeutic Targets. PMID 29889582 DOI: 10.1080/14728222.2018.1487953  1
2018 Mendez FM, Núñez FJ, Zorrilla-Veloz RI, Lowenstein PR, Castro MG. Native Chromatin Immunoprecipitation Using Murine Brain Tumor Neurospheres. Journal of Visualized Experiments : Jove. PMID 29443090 DOI: 10.3791/57016  1
2018 Kamran N, Alghamri MS, Nunez FJ, Shah D, Asad AS, Candolfi M, Altshuler D, Lowenstein PR, Castro MG. Current state and future prospects of immunotherapy for glioma. Immunotherapy. 10: 317-339. PMID 29421984 DOI: 10.2217/imt-2017-0122  1
2018 Kamran N, Li Y, Sierra M, Alghamri MS, Kadiyala P, Appelman HD, Edwards M, Lowenstein PR, Castro MG. Melanoma induced immunosuppression is mediated by hematopoietic dysregulation. Oncoimmunology. 7: e1408750. PMID 29399415 DOI: 10.1080/2162402X.2017.1408750  1
2017 Koschmann C, Farooqui Z, Kasaian K, Cao X, Zamler D, Stallard S, Venneti S, Hervey-Jumper S, Garton H, Muraszko K, Franchi L, Robertson PL, Leonard M, Opipari V, Castro MG, ... Lowenstein PR, et al. Multi-focal sequencing of a diffuse intrinsic pontine glioma establishes PTEN loss as an early event. Npj Precision Oncology. 1: 32. PMID 29872713 DOI: 10.1038/s41698-017-0033-y  1
2017 Lowenstein PR, Castro MG. Evolutionary basis of a new approach for the treatment of malignant brain tumors: From mice to humans. Clinical Immunology (Orlando, Fla.). PMID 28720549 DOI: 10.1016/j.clim.2017.07.006  1
2017 Chandran M, Candolfi M, Shah D, Mineharu Y, Yadav V, Koschmann C, Asad AS, Lowenstein PR, Castro MG. Single vs. combination immunotherapeutic strategies for glioma. Expert Opinion On Biological Therapy. PMID 28286975 DOI: 10.1080/14712598.2017.1305353  1
2017 Kamran N, Kadiyala P, Saxena M, Candolfi M, Li Y, Moreno-Ayala MA, Raja N, Shah D, Lowenstein PR, Castro MG. Immunosuppressive Myeloid Cells' Blockade in the Glioma Microenvironment Enhances the Efficacy of Immune-Stimulatory Gene Therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 25: 232-248. PMID 28129117 DOI: 10.1016/j.ymthe.2016.10.003  1
2017 Koschmann C, Nunez FJ, Mendez F, Brosnan-Cashman JA, Meeker AK, Lowenstein PR, Castro MG. Mutated Chromatin Regulatory Factors as Tumor Drivers in Cancer. Cancer Research. PMID 28062403 DOI: 10.1158/0008-5472.CAN-16-2301  1
2017 Ashley SL, Pretto CD, Stier MT, Kadiyala P, Castro-Jorge L, Hsu TH, Doherty R, Carnahan KE, Castro MG, Lowenstein PR, Spindler KR. Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1. Journal of Virology. PMID 28053109 DOI: 10.1128/JVI.01412-16  1
2016 Yadav VN, Zamler D, Baker GJ, Kadiyala P, Erdreich-Epstein A, DeCarvalho AC, Mikkelsen T, Castro MG, Lowenstein PR. CXCR4 increases in-vivo glioma perivascular invasion, and reduces radiation induced apoptosis: A genetic knockdown study. Oncotarget. PMID 27863376 DOI: 10.18632/oncotarget.13295  1
2016 Kamran N, Chandran M, Lowenstein PR, Castro MG. Immature myeloid cells in the tumor microenvironment: Implications for immunotherapy. Clinical Immunology (Orlando, Fla.). PMID 27777083 DOI: 10.1016/j.clim.2016.10.008  1
2016 Koschmann C, Zamler D, MacKay A, Robinson D, Wu YM, Doherty R, Marini B, Tran D, Garton H, Muraszko K, Robertson P, Leonard M, Zhao L, Bixby D, Peterson L, ... ... Lowenstein PR, et al. Characterizing and targeting PDGFRA alterations in pediatric high-grade glioma. Oncotarget. PMID 27582545 DOI: 10.18632/oncotarget.11602  1
2016 Wilson TJ, Zamler DB, Doherty R, Castro MG, Lowenstein PR. Reversibility of glioma stem cells' phenotypes explains their complex in vitro and in vivo behavior. Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells. Oncotarget. PMID 27564115 DOI: 10.18632/oncotarget.11589  1
2016 Calinescu AA, Yadav VN, Carballo E, Kadiyala P, Tran D, Zamler D, Doherty R, Srikanth M, Lowenstein PR, Castro MG. Survival and proliferation of neural progenitor derived glioblastomas under hypoxic stress is controlled by a CXCL12/CXCR4 autocrine positive feedback mechanism. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27542769 DOI: 10.1158/1078-0432.CCR-15-2888  1
2016 Lowenstein PR, Castro MG. Multiple expressed endogenous glioma epitopes as novel vaccines for gliomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 27521444 DOI: 10.1158/1078-0432.CCR-16-1477  1
2016 Baker GJ, Chockley P, Zamler D, Castro MG, Lowenstein PR. Natural killer cells require monocytic Gr-1(+)/CD11b(+) myeloid cells to eradicate orthotopically engrafted glioma cells. Oncoimmunology. 5: e1163461. PMID 27471637 DOI: 10.1080/2162402X.2016.1163461  1
2016 Kamran N, Calinescu A, Candolfi M, Chandran M, Mineharu Y, Assad AS, Koschmann C, Nunez F, Lowenstein P, Castro M. Recent advances and future of immunotherapy for glioblastoma. Expert Opinion On Biological Therapy. PMID 27411023 DOI: 10.1080/14712598.2016.1212012  0.76
2016 Koschmann C, Lowenstein PR, Castro MG. ATRX mutations and glioblastoma: Impaired DNA damage repair, alternative lengthening of telomeres, and genetic instability. Molecular & Cellular Oncology. 3: e1167158. PMID 27314101 DOI: 10.1080/23723556.2016.1167158  1
2016 VanderVeen NT, Raja NS, Yi E, Appelman H, Ng P, Palmer D, Zamler D, Dzaman M, Lowenstein P, Castro M. Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model. Human Gene Therapy Methods. PMID 27056322 DOI: 10.1089/hgtb.2015.168  1
2016 Koschmann C, Calinescu AA, Nunez FJ, Mackay A, Fazal-Salom J, Thomas D, Mendez F, Kamran N, Dzaman M, Mulpuri L, Krasinkiewicz J, Doherty R, Lemons R, Brosnan-Cashman JA, Li Y, ... ... Lowenstein PR, et al. ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma. Science Translational Medicine. 8: 328ra28. PMID 26936505 DOI: 10.1126/scitranslmed.aac8228  1
2016 Kamran N, Candolfi M, Baker GJ, Ayala MM, Dzaman M, Lowenstein PR, Castro MG. Gene Therapy for the Treatment of Neurological Disorders: Central Nervous System Neoplasms. Methods in Molecular Biology (Clifton, N.J.). 1382: 467-82. PMID 26611605 DOI: 10.1007/978-1-4939-3271-9_31  1
2015 Baker GJ, Castro MG, Lowenstein PR. Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells. Journal of Visualized Experiments : Jove. PMID 26650233 DOI: 10.3791/53676  1
2015 Calinescu AA, Kamran N, Baker G, Mineharu Y, Lowenstein PR, Castro MG. Overview of current immunotherapeutic strategies for glioma. Immunotherapy. 7: 1073-104. PMID 26598957 DOI: 10.2217/imt.15.75  1
2015 Calinescu AA, Núñez FJ, Koschmann C, Kolb BL, Lowenstein PR, Castro MG. Transposon mediated integration of plasmid DNA into the subventricular zone of neonatal mice to generate novel models of glioblastoma. Journal of Visualized Experiments : Jove. PMID 25741859 DOI: 10.3791/52443  1
2015 Lowenstein PR, Castro MG. Glioma trials and viral tribulations: can anything be concluded from non-controlled trials? Journal of Neurology, Neurosurgery, and Psychiatry. 86: 125. PMID 25280917 DOI: 10.1136/jnnp-2014-308406  1
2014 Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, ... ... Lowenstein PR, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 3: e955691. PMID 25941621 DOI: 10.4161/21624011.2014.955691  1
2014 Lowenstein PR, Baker GJ, Castro MG. Cracking the glioma-NK inhibitory code: toward successful innate immunotherapy. Oncoimmunology. 3: e965573. PMID 25941594 DOI: 10.4161/21624011.2014.965573  1
2014 Mineharu Y, Kamran N, Lowenstein PR, Castro MG. Blockade of mTOR signaling via rapamycin combined with immunotherapy augments antiglioma cytotoxic and memory T-cell functions. Molecular Cancer Therapeutics. 13: 3024-36. PMID 25256739 DOI: 10.1158/1535-7163.MCT-14-0400  1
2014 Baker GJ, Yadav VN, Motsch S, Koschmann C, Calinescu AA, Mineharu Y, Camelo-Piragua SI, Orringer D, Bannykh S, Nichols WS, deCarvalho AC, Mikkelsen T, Castro MG, Lowenstein PR. Mechanisms of glioma formation: iterative perivascular glioma growth and invasion leads to tumor progression, VEGF-independent vascularization, and resistance to antiangiogenic therapy. Neoplasia (New York, N.Y.). 16: 543-61. PMID 25117977 DOI: 10.1016/j.neo.2014.06.003  1
2014 VanderVeen N, Paran C, Appelhans A, Krasinkiewicz J, Lemons R, Appelman H, Doherty R, Palmer D, Ng P, Lowenstein PR, Castro MG. Marmosets as a preclinical model for testing "off-label" use of doxycycline to turn on Flt3L expression from high-capacity adenovirus vectors. Molecular Therapy. Methods & Clinical Development. 1. PMID 25068145 DOI: 10.1038/mtm.2013.10  1
2014 Baker GJ, Chockley P, Yadav VN, Doherty R, Ritt M, Sivaramakrishnan S, Castro MG, Lowenstein PR. Natural killer cells eradicate galectin-1-deficient glioma in the absence of adaptive immunity. Cancer Research. 74: 5079-90. PMID 25038230 DOI: 10.1158/0008-5472.CAN-14-1203  1
2014 Castro MG, Baker GJ, Lowenstein PR. Blocking immunosuppressive checkpoints for glioma therapy: the more the Merrier! Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5147-9. PMID 24879798 DOI: 10.1158/1078-0432.CCR-14-0820  1
2014 Lowenstein PR, Castro MG. The value of EGFRvIII as the target for glioma vaccines. American Society of Clinical Oncology Educational Book / Asco. American Society of Clinical Oncology. Meeting. 42-50. PMID 24857059 DOI: 10.14694/EdBook_AM.2014.34.42  1
2014 Assi H, Espinosa J, Suprise S, Sofroniew M, Doherty R, Zamler D, Lowenstein PR, Castro MG. Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. Plos One. 9: e96318. PMID 24806510 DOI: 10.1371/journal.pone.0096318  1
2014 Castro MG, Candolfi M, Wilson TJ, Calinescu A, Paran C, Kamran N, Koschmann C, Moreno-Ayala MA, Assi H, Lowenstein PR. Adenoviral vector-mediated gene therapy for gliomas: coming of age. Expert Opinion On Biological Therapy. 14: 1241-57. PMID 24773178 DOI: 10.1517/14712598.2014.915307  1
2014 Lynes J, Wibowo M, Koschmann C, Baker GJ, Saxena V, Muhammad AK, Bondale N, Klein J, Assi H, Lieberman AP, Castro MG, Lowenstein PR. Lentiviral-induced high-grade gliomas in rats: the effects of PDGFB, HRAS-G12V, AKT, and IDH1-R132H. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 623-35. PMID 24752661 DOI: 10.1007/s13311-014-0269-y  1
2014 Assi HH, Paran C, VanderVeen N, Savakus J, Doherty R, Petruzzella E, Hoeschele JD, Appelman H, Raptis L, Mikkelsen T, Lowenstein PR, Castro MG. Preclinical characterization of signal transducer and activator of transcription 3 small molecule inhibitors for primary and metastatic brain cancer therapy. The Journal of Pharmacology and Experimental Therapeutics. 349: 458-69. PMID 24696041 DOI: 10.1124/jpet.114.214619  1
2014 Candolfi M, Yagiz K, Wibowo M, Ahlzadeh GE, Puntel M, Ghiasi H, Kamran N, Paran C, Lowenstein PR, Castro MG. Temozolomide does not impair gene therapy-mediated antitumor immunity in syngeneic brain tumor models. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1555-65. PMID 24501391 DOI: 10.1158/1078-0432.CCR-13-2140  1
2014 Lowenstein PR, Yadav VN, Chockley P, Castro M. There must be a way out of here: identifying a safe and efficient combination of promoter, transgene, and vector backbone for gene therapy of neurological disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 246-7. PMID 24487564 DOI: 10.1038/mt.2013.297  1
2014 Sauderson NSR, Castro MG, Lowenstein PR. Gene Therapy From Theoretical Potential to Clinical Implementation Reference Module in Biomedical Research. DOI: 10.1016/B978-0-12-801238-3.05502-1  1
2013 Mineharu Y, Castro MG, Lowenstein PR, Sakai N, Miyamoto S. Dendritic cell-based immunotherapy for glioma: multiple regimens and implications in clinical trials. Neurologia Medico-Chirurgica. 53: 741-54. PMID 24140772 DOI: DN/JST.JSTAGE/nmc/ra2013-0234  1
2013 Castro MG, Lowenstein PR. Neuro-oncology: The long and winding road--gene therapy for glioma. Nature Reviews. Neurology. 9: 609-10. PMID 24061435 DOI: 10.1038/nrneurol.2013.198  1
2013 VanderVeen N, Paran C, Krasinkiewicz J, Zhao L, Palmer D, Hervey-Jumper S, Ng P, Lowenstein PR, Castro MG. Effectiveness and preclinical safety profile of doxycycline to be used "off-label" to induce therapeutic transgene expression in a phase I clinical trial for glioma. Human Gene Therapy. Clinical Development. 24: 116-26. PMID 24007469 DOI: 10.1089/humc.2013.139  1
2013 Simonato M, Bennett J, Boulis NM, Castro MG, Fink DJ, Goins WF, Gray SJ, Lowenstein PR, Vandenberghe LH, Wilson TJ, Wolfe JH, Glorioso JC. Progress in gene therapy for neurological disorders. Nature Reviews. Neurology. 9: 277-91. PMID 23609618 DOI: 10.1038/nrneurol.2013.56  1
2013 Puntel M, A K M GM, Farrokhi C, Vanderveen N, Paran C, Appelhans A, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Kaur S, Kennedy S, Palmer D, Ng P, ... ... Lowenstein PR, et al. Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma. Toxicology and Applied Pharmacology. 268: 318-30. PMID 23403069 DOI: 10.1016/j.taap.2013.02.001  1
2013 Sauderson NSR, Castro MG, Lowenstein PR. Gene Therapy: From Theoretical Potential to Clinical Implementation Emery and Rimoin's Principles and Practice of Medical Genetics. 1-32. DOI: 10.1016/B978-0-12-383834-6.00037-9  1
2013 Assi H, Candolfi M, Lowenstein PR, Castro MG. Rodent glioma models: Intracranial stereotactic allografts and xenografts Neuromethods. 77: 229-243. DOI: 10.1007/7657_2011_33  1
2012 Mineharu Y, Muhammad AK, Yagiz K, Candolfi M, Kroeger KM, Xiong W, Puntel M, Liu C, Levy E, Lugo C, Kocharian A, Allison JP, Curran MA, Lowenstein PR, Castro MG. Gene therapy-mediated reprogramming tumor infiltrating T cells using IL-2 and inhibiting NF-κB signaling improves the efficacy of immunotherapy in a brain cancer model. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 9: 827-43. PMID 22996231 DOI: 10.1007/s13311-012-0144-7  1
2012 Candolfi M, King GD, Yagiz K, Curtin JF, Mineharu Y, Muhammad AK, Foulad D, Kroeger KM, Barnett N, Josien R, Lowenstein PR, Castro MG. Plasmacytoid dendritic cells in the tumor microenvironment: immune targets for glioma therapeutics. Neoplasia (New York, N.Y.). 14: 757-70. PMID 22952428 DOI: 10.1593/neo.12794  1
2012 Muhammad AK, Xiong W, Puntel M, Farrokhi C, Kroeger KM, Salem A, Lacayo L, Pechnick RN, Kelson KR, Palmer D, Ng P, Liu C, Lowenstein PR, Castro MG. Safety profile of gutless adenovirus vectors delivered into the normal brain parenchyma: implications for a glioma phase 1 clinical trial. Human Gene Therapy Methods. 23: 271-84. PMID 22950971 DOI: 10.1089/hgtb.2012.060  1
2012 Assi H, Candolfi M, Baker G, Mineharu Y, Lowenstein PR, Castro MG. Gene therapy for brain tumors: basic developments and clinical implementation. Neuroscience Letters. 527: 71-7. PMID 22906921 DOI: 10.1016/j.neulet.2012.08.003  1
2012 Sanderson NS, Puntel M, Kroeger KM, Bondale NS, Swerdlow M, Iranmanesh N, Yagita H, Ibrahim A, Castro MG, Lowenstein PR. Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 7835-40. PMID 22547816 DOI: 10.1073/pnas.1116058109  1
2012 Lowenstein PR, Castro MG. Pushing the limits of glioma resection using electrophysiologic brain mapping. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 30: 2437-40. PMID 22529267 DOI: 10.1200/JCO.2011.40.6959  1
2012 Zirger JM, Puntel M, Bergeron J, Wibowo M, Moridzadeh R, Bondale N, Barcia C, Kroeger KM, Liu C, Castro MG, Lowenstein PR. Immune-mediated loss of transgene expression from virally transduced brain cells is irreversible, mediated by IFNγ, perforin, and TNFα, and due to the elimination of transduced cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 808-19. PMID 22233583 DOI: 10.1038/mt.2011.243  1
2011 King GD, Muhammad AG, Larocque D, Kelson KR, Xiong W, Liu C, Sanderson NS, Kroeger KM, Castro MG, Lowenstein PR. Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1793-1801. PMID 28160649 DOI: 10.1038/mt.2011.77  1
2011 Candolfi M, Curtin JF, Yagiz K, Assi H, Wibowo MK, Alzadeh GE, Foulad D, Muhammad AK, Salehi S, Keech N, Puntel M, Liu C, Sanderson NR, Kroeger KM, Dunn R, ... ... Lowenstein PR, et al. B cells are critical to T-cell-mediated antitumor immunity induced by a combined immune-stimulatory/conditionally cytotoxic therapy for glioblastoma. Neoplasia (New York, N.Y.). 13: 947-60. PMID 22028620 DOI: 10.1593/neo.11024  1
2011 Puntel M, Barrett R, Sanderson NS, Kroeger KM, Bondale N, Wibowo M, Kennedy S, Liu C, Castro MG, Lowenstein PR. Identification and visualization of CD8+ T cell mediated IFN-γ signaling in target cells during an antiviral immune response in the brain. Plos One. 6: e23523. PMID 21897844 DOI: 10.1371/journal.pone.0023523  1
2011 Candolfi M, Kroeger KM, Xiong W, Liu C, Puntel M, Yagiz K, Muhammad AG, Mineharu Y, Foulad D, Wibowo M, Assi H, Baker GJ, Lowenstein PR, Castro MG. Targeted toxins for glioblastoma multiforme: pre-clinical studies and clinical implementation. Anti-Cancer Agents in Medicinal Chemistry. 11: 729-38. PMID 21707497  1
2011 Mineharu Y, King GD, Muhammad AK, Bannykh S, Kroeger KM, Liu C, Lowenstein PR, Castro MG. Engineering the brain tumor microenvironment enhances the efficacy of dendritic cell vaccination: implications for clinical trial design. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 4705-18. PMID 21632862 DOI: 10.1158/1078-0432.CCR-11-0915  1
2011 Flotte TR, Frederickson RM, Lowenstein PR, Mueller C. Moving forward toward a cure for Parkinson's: neuropathology of the nigrostriatal pathway determines the location of growth factor delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 827-9. PMID 21532611 DOI: 10.1038/mt.2011.76  1
2011 King GD, Muhammad AK, Larocque D, Kelson KR, Xiong W, Liu C, Sanderson NS, Kroeger KM, Castro MG, Lowenstein PR. Combined Flt3L/TK gene therapy induces immunological surveillance which mediates an immune response against a surrogate brain tumor neoantigen. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 1793-801. PMID 21505426 DOI: 10.1038/mt.2011.77  1
2011 Castro MG, Candolfi M, Kroeger K, King GD, Curtin JF, Yagiz K, Mineharu Y, Assi H, Wibowo M, Ghulam Muhammad AK, Foulad D, Puntel M, Lowenstein PR. Gene therapy and targeted toxins for glioma. Current Gene Therapy. 11: 155-80. PMID 21453286  1
2011 Mandel RJ, Lowenstein PR, Byrne BJ. AAV6-mediated gene silencing fALS short. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 231-3. PMID 21289637 DOI: 10.1038/mt.2010.306  1
2010 Kroeger KM, Muhammad AK, Baker GJ, Assi H, Wibowo MK, Xiong W, Yagiz K, Candolfi M, Lowenstein PR, Castro MG. Gene therapy and virotherapy: novel therapeutic approaches for brain tumors. Discovery Medicine. 10: 293-304. PMID 21034670  1
2010 Candolfi M, Xiong W, Yagiz K, Liu C, Muhammad AK, Puntel M, Foulad D, Zadmehr A, Ahlzadeh GE, Kroeger KM, Tesarfreund M, Lee S, Debinski W, Sareen D, Svendsen CN, ... ... Lowenstein PR, et al. Gene therapy-mediated delivery of targeted cytotoxins for glioma therapeutics. Proceedings of the National Academy of Sciences of the United States of America. 107: 20021-6. PMID 21030678 DOI: 10.1073/pnas.1008261107  1
2010 Lowenstein PR. Cancer vaccines in glioma: how to balance the challenges of small trials, efficiency, and potential adverse events. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 28: 4670-3. PMID 20921460 DOI: 10.1200/JCO.2010.32.1117  1
2010 Larocque D, Sanderson NS, Bergeron J, Curtin JF, Girton J, Wibowo M, Bondale N, Kroeger KM, Yang J, Lacayo LM, Reyes KC, Farrokhi C, Pechnick RN, Castro MG, Lowenstein PR. Exogenous fms-like tyrosine kinase 3 ligand overrides brain immune privilege and facilitates recognition of a neo-antigen without causing autoimmune neuropathology. Proceedings of the National Academy of Sciences of the United States of America. 107: 14443-8. PMID 20660723 DOI: 10.1073/pnas.0913496107  1
2010 Xiong W, Candolfi M, Liu C, Muhammad AK, Yagiz K, Puntel M, Moore PF, Avalos J, Young JD, Khan D, Donelson R, Pluhar GE, Ohlfest JR, Wawrowsky K, Lowenstein PR, et al. Human Flt3L generates dendritic cells from canine peripheral blood precursors: implications for a dog glioma clinical trial. Plos One. 5: e11074. PMID 20552015 DOI: 10.1371/journal.pone.0011074  1
2010 Puntel M, Muhammad AK, Candolfi M, Salem A, Yagiz K, Farrokhi C, Kroeger KM, Xiong W, Curtin JF, Liu C, Bondale NS, Lerner J, Pechnick RN, Palmer D, Ng P, ... Lowenstein PR, et al. A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics. Journal of Virology. 84: 6007-17. PMID 20375153 DOI: 10.1128/JVI.00398-10  1
2010 Pluhar GE, Grogan PT, Seiler C, Goulart M, Santacruz KS, Carlson C, Chen W, Olin MR, Lowenstein PR, Castro MG, Haines SJ, Ohlfest JR. Anti-tumor immune response correlates with neurological symptoms in a dog with spontaneous astrocytoma treated by gene and vaccine therapy. Vaccine. 28: 3371-8. PMID 20197146 DOI: 10.1016/j.vaccine.2010.02.082  1
2010 Muhammad AK, Puntel M, Candolfi M, Salem A, Yagiz K, Farrokhi C, Kroeger KM, Xiong W, Curtin JF, Liu C, Lawrence K, Bondale NS, Lerner J, Baker GJ, Foulad D, ... ... Lowenstein PR, et al. Study of the efficacy, biodistribution, and safety profile of therapeutic gutless adenovirus vectors as a prelude to a phase I clinical trial for glioblastoma. Clinical Pharmacology and Therapeutics. 88: 204-13. PMID 20164833 DOI: 10.1038/clpt.2009.260  1
2010 Yang J, Sanderson NS, Wawrowsky K, Puntel M, Castro MG, Lowenstein PR. Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo. Proceedings of the National Academy of Sciences of the United States of America. 107: 4716-21. PMID 20133734 DOI: 10.1073/pnas.0911587107  1
2010 Puntel M, Kroeger KM, Sanderson NS, Thomas CE, Castro MG, Lowenstein PR. Gene transfer into rat brain using adenoviral vectors. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.24. PMID 20066657 DOI: 10.1002/0471142301.ns0424s50  1
2009 Lowenstein PR. Risk in clinical research: size matters! Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1833-4. PMID 19876046 DOI: 10.1038/mt.2009.242  1
2009 Candolfi M, Kroeger KM, Muhammad AK, Yagiz K, Farrokhi C, Pechnick RN, Lowenstein PR, Castro MG. Gene therapy for brain cancer: combination therapies provide enhanced efficacy and safety. Current Gene Therapy. 9: 409-21. PMID 19860655 DOI: 10.2174/156652309789753301  1
2009 Lowenstein PR, Castro MG. Uncertainty in the translation of preclinical experiments to clinical trials. Why do most phase III clinical trials fail? Current Gene Therapy. 9: 368-74. PMID 19860651 DOI: 10.2174/156652309789753392  1
2009 Castro MG, Lowenstein PR. Gene therapy continues to make progress: clinical and regulatory perspectives. Current Gene Therapy. 9: 327-8. PMID 19860647 DOI: 10.2174/156652309789753374  1
2009 Lowenstein PR, Lowenstein ED, Castro MG. Challenges in the evaluation, consent, ethics and history of early clinical trials - Implications of the Tuskegee 'trial' for safer and more ethical clinical trials. Current Opinion in Molecular Therapeutics. 11: 481-4. PMID 19806495  1
2009 Ghulam Muhammad AK, Candolfi M, King GD, Yagiz K, Foulad D, Mineharu Y, Kroeger KM, Treuer KA, Nichols WS, Sanderson NS, Yang J, Khayznikov M, Van Rooijen N, Lowenstein PR, Castro MG. Antiglioma immunological memory in response to conditional cytotoxic/immune-stimulatory gene therapy: humoral and cellular immunity lead to tumor regression. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6113-27. PMID 19789315 DOI: 10.1158/1078-0432.CCR-09-1087  1
2009 Vit JP, Ohara PT, Sundberg C, Rubi B, Maechler P, Liu C, Puntel M, Lowenstein P, Castro M, Jasmin L. Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia Molecular Pain. 5. PMID 19656360 DOI: 10.1186/1744-8069-5-42  1
2009 Barcia C, Gómez A, Gallego-Sanchez JM, Perez-Vallés A, Castro MG, Lowenstein PR, Barcia C, Herrero MT. Infiltrating CTLs in human glioblastoma establish immunological synapses with tumorigenic cells. The American Journal of Pathology. 175: 786-98. PMID 19628762 DOI: 10.2353/ajpath.2009.081034  1
2009 Candolfi M, Yagiz K, Foulad D, Alzadeh GE, Tesarfreund M, Muhammad AK, Puntel M, Kroeger KM, Liu C, Lee S, Curtin JF, King GD, Lerner J, Sato K, Mineharu Y, ... ... Lowenstein PR, et al. Release of HMGB1 in response to proapoptotic glioma killing strategies: efficacy and neurotoxicity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4401-14. PMID 19570774 DOI: 10.1158/1078-0432.CCR-09-0155  1
2009 Curtin JF, Liu N, Candolfi M, Xiong W, Assi H, Yagiz K, Edwards MR, Michelsen KS, Kroeger KM, Liu C, Muhammad AK, Clark MC, Arditi M, Comin-Anduix B, Ribas A, ... Lowenstein PR, et al. HMGB1 mediates endogenous TLR2 activation and brain tumor regression. Plos Medicine. 6: e10. PMID 19143470 DOI: 10.1371/journal.pmed.1000010  1
2009 Lowenstein PR. Crossing the rubicon. Nature Biotechnology. 27: 42-4. PMID 19131996 DOI: 10.1038/nbt0109-42  1
2009 Puntel M, Barrett RJ, Mondkar S, Saxena V, Kroeger KM, Muhammad AK, Liu C, Bondale N, Sciascia S, Xiong W, Shi Y, Salem A, Zadmehr A, Huynh P, Palmer D, ... ... Lowenstein PR, et al. Herpes simplex virus type 1 thymidine kinase sequence fused to the lacz gene increases levels of {beta}-galactosidase activity per genome of high-capacity but not first-generation adenoviral vectors in vitro and in vivo. Journal of Virology. 83: 2004-10. PMID 19073729 DOI: 10.1128/JVI.01298-08  1
2008 King GD, Kroeger KM, Bresee CJ, Candolfi M, Liu C, Manalo CM, Muhammad AG, Pechnick RN, Lowenstein PR, Castro MG. Flt3L in Combination With HSV1-TK-mediated Gene Therapy Reverses Brain Tumor-induced Behavioral Deficits. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 682-690. PMID 28178463 DOI: 10.1038/mt.2008.18  1
2008 Southgate T, Kroeger KM, Liu C, Lowenstein PR, Castro MG. Gene transfer into neural cells in vitro using adenoviral vectors. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.23. PMID 18972378 DOI: 10.1002/0471142301.ns0423s45  1
2008 Lowenstein PR. A call for physiopathological ethics. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1771-2. PMID 18956015 DOI: 10.1038/mt.2008.218  1
2008 Lowenstein PR. Clinical trials in gene therapy: ethics of informed consent and the future of experimental medicine. Current Opinion in Molecular Therapeutics. 10: 428-30. PMID 18830917  1
2008 Barcia C, Sanderson NS, Barrett RJ, Wawrowsky K, Kroeger KM, Puntel M, Liu C, Castro MG, Lowenstein PR. T cells' immunological synapses induce polarization of brain astrocytes in vivo and in vitro: a novel astrocyte response mechanism to cellular injury. Plos One. 3: e2977. PMID 18714338 DOI: 10.1371/journal.pone.0002977  1
2008 Barcia C, Gomez A, de Pablos V, Fernández-Villalba E, Liu C, Kroeger KM, Martín J, Barreiro AF, Castro MG, Lowenstein PR, Herrero MT. CD20, CD3, and CD40 ligand microclusters segregate three-dimensionally in vivo at B-cell-T-cell immunological synapses after viral immunity in primate brain. Journal of Virology. 82: 9978-93. PMID 18684835 DOI: 10.1128/JVI.01326-08  1
2008 Lowenstein PR. With a little help from my f(X)riends!: the basis of Ad5-mediated transduction of the liver revealed. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1004-6. PMID 18500239 DOI: 10.1038/mt.2008.80  1
2008 Curtin JF, Candolfi M, Puntel M, Xiong W, Muhammad AK, Kroeger K, Mondkar S, Liu C, Bondale N, Lowenstein PR, Castro MG. Regulated expression of adenoviral vectors-based gene therapies: therapeutic expression of toxins and immune-modulators. Methods in Molecular Biology (Clifton, N.J.). 434: 239-66. PMID 18470649 DOI: 10.1007/978-1-60327-248-3_15  1
2008 Curtin JF, Candolfi M, Fakhouri TM, Liu C, Alden A, Edwards M, Lowenstein PR, Castro MG. Treg depletion inhibits efficacy of cancer immunotherapy: implications for clinical trials. Plos One. 3: e1983. PMID 18431473 DOI: 10.1371/journal.pone.0001983  1
2008 Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene delivery to the nervous system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 640-6. PMID 18362921 DOI: 10.1038/mt.2008.42  1
2008 Curtin JF, Candolfi M, Xiong W, Lowenstein PR, Castro MG. Turning the gene tap off; implications of regulating gene expression for cancer therapeutics. Molecular Cancer Therapeutics. 7: 439-48. PMID 18347132 DOI: 10.1158/1535-7163.MCT-07-2328  1
2008 King GD, Muhammad AK, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG. High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity. Journal of Virology. 82: 4680-4. PMID 18287240 DOI: 10.1128/JVI.00232-08  1
2008 King GD, Kroeger KM, Bresee CJ, Candolfi M, Liu C, Manalo CM, Muhammad AK, Pechnick RN, Lowenstein PR, Castro MG. Flt3L in combination with HSV1-TK-mediated gene therapy reverses brain tumor-induced behavioral deficits. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 682-90. PMID 18283279 DOI: 10.1038/mt.2008.18  1
2008 Barcia C, Wawrowsky K, Barrett RJ, Liu C, Castro MG, Lowenstein PR. In vivo polarization of IFN-gamma at Kupfer and non-Kupfer immunological synapses during the clearance of virally infected brain cells. Journal of Immunology (Baltimore, Md. : 1950). 180: 1344-52. PMID 18209028  1
2008 Xiong W, Candolfi M, Kroeger KM, Puntel M, Mondkar S, Larocque D, Liu C, Curtin JF, Palmer D, Ng P, Lowenstein PR, Castro MG. Immunization against the transgene but not the TetON switch reduces expression from gutless adenoviral vectors in the brain. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 343-51. PMID 18180781 DOI: 10.1038/sj.mt.6300375  1
2008 King GD, Muhammad AK, Curtin JF, Barcia C, Puntel M, Liu C, Honig SB, Candolfi M, Mondkar S, Lowenstein PR, Castro MG. Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model. Neuro-Oncology. 10: 19-31. PMID 18079358 DOI: 10.1215/15228517-2007-045  1
2008 King GD, Muhammad AKMG, Xiong W, Kroeger KM, Puntel M, Larocque D, Palmer D, Ng P, Lowenstein PR, Castro MG. High-capacity adenovirus vector-mediated anti-glioma gene therapy in the presence of systemic antiadenovirus immunity (Journal of Virology (2008) 82, 9, (4680-4684)) Journal of Virology. 82: 6087. DOI: 10.1128/JVI.00828-08  1
2008 Lowenstein PR, Koreger KM, Castro MG. Viral gene therapy for central nervous system diseases Neurotropic Viral Infections. 424-434. DOI: 10.1017/CBO9780511541728.028  0.96
2008 Bergmann C, Lowenstein P. MHC class i expression and CD8 T cell function: Towards the cell biology of T-APC interactions in the infected brain Central Nervous System Diseases and Inflammation. 277-306. DOI: 10.1007/978-0-387-73894-9_14  1
2007 Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG. Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Current Gene Therapy. 7: 347-60. PMID 17979681 DOI: 10.2174/156652307782151498  1
2007 Lowenstein PR, Kroeger K, Castro MG. Immunology of neurological gene therapy: how T cells modulate viral vector-mediated therapeutic transgene expression through immunological synapses. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 4: 715-24. PMID 17920552 DOI: 10.1016/j.nurt.2007.07.010  1
2007 Barcia C, Jimenez-Dalmaroni M, Kroeger KM, Puntel M, Rapaport AJ, Larocque D, King GD, Johnson SA, Liu C, Xiong W, Candolfi M, Mondkar S, Ng P, Palmer D, Castro MG, ... Lowenstein PR, et al. One-year expression from high-capacity adenoviral vectors in the brains of animals with pre-existing anti-adenoviral immunity: clinical implications. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 2154-63. PMID 17895861 DOI: 10.1038/sj.mt.6300305  1
2007 Oh S, Odland R, Wilson SR, Kroeger KM, Liu C, Lowenstein PR, Castro MG, Hall WA, Ohlfest JR. Improved distribution of small molecules and viral vectors in the murine brain using a hollow fiber catheter. Journal of Neurosurgery. 107: 568-77. PMID 17886557 DOI: 10.3171/JNS-07/09/0568  1
2007 Candolfi M, Curtin JF, Nichols WS, Muhammad AG, King GD, Pluhar GE, McNiel EA, Ohlfest JR, Freese AB, Moore PF, Lerner J, Lowenstein PR, Castro MG. Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progression. Journal of Neuro-Oncology. 85: 133-48. PMID 17874037 DOI: 10.1007/s11060-007-9400-9  1
2007 Oh S, Pluhar GE, McNeil EA, Kroeger KM, Liu C, Castro MG, Lowenstein PR, Freese A, Ohlfest JR. Efficacy of nonviral gene transfer in the canine brain. Journal of Neurosurgery. 107: 136-44. PMID 17639883 DOI: 10.3171/JNS-07/07/0136  1
2007 Candolfi M, Pluhar GE, Kroeger K, Puntel M, Curtin J, Barcia C, Muhammad AK, Xiong W, Liu C, Mondkar S, Kuoy W, Kang T, McNeil EA, Freese AB, Ohlfest JR, ... ... Lowenstein PR, et al. Optimization of adenoviral vector-mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro. Neuro-Oncology. 9: 245-58. PMID 17522335 DOI: 10.1215/15228517-2007-012  1
2007 Candolfi M, Kroeger KM, Pluhar GE, Bergeron J, Puntel M, Curtin JF, McNiel EA, Freese AB, Ohlfest JR, Moore P, Lowenstein PR, Castro MG. Adenoviral-mediated gene transfer into the canine brain in vivo. Neurosurgery. 60: 167-77; discussion 1. PMID 17228266 DOI: 10.1227/01.NEU.0000249210.89096.6C  1
2007 Lowenstein PR, Castro MG. Immune Responses to Viral Vectors Injected Systemically or into the CNS Concepts in Genetic Medicine. 167-179. DOI: 10.1002/9780470184585.ch14  1
2007 Lowenstein PR, Castro MG. The Brain as a Target for Gene Therapy Concepts in Genetic Medicine. 153-165. DOI: 10.1002/9780470184585.ch13  1
2006 Barcia C, Gerdes C, Xiong WD, Thomas CE, Liu C, Kroeger KM, Castro MG, Lowenstein PR. Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cells. Neuron Glia Biology. 2: 309-22. PMID 18084640 DOI: 10.1017/S1740925X07000579  1
2006 Zirger JM, Liu C, Barcia C, Castro MG, Lowenstein PR. Immune regulation of transgene expression in the brain: B cells regulate an early phase of elimination of transgene expression from adenoviral vectors. Viral Immunology. 19: 508-17. PMID 16987068 DOI: 10.1089/vim.2006.19.508  1
2006 Barcia C, Thomas CE, Curtin JF, King GD, Wawrowsky K, Candolfi M, Xiong WD, Liu C, Kroeger K, Boyer O, Kupiec-Weglinski J, Klatzmann D, Castro MG, Lowenstein PR. In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brain. The Journal of Experimental Medicine. 203: 2095-107. PMID 16923851 DOI: 10.1084/jem.20060420  1
2006 Candolfi M, Curtin JF, Xiong WD, Kroeger KM, Liu C, Rentsendorj A, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, Lowenstein PR, Castro MG. Effective high-capacity gutless adenoviral vectors mediate transgene expression in human glioma cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 371-81. PMID 16798098 DOI: 10.1016/j.ymthe.2006.05.006  1
2006 Puntel M, Curtin JF, Zirger JM, Muhammad AK, Xiong W, Liu C, Hu J, Kroeger KM, Czer P, Sciascia S, Mondkar S, Lowenstein PR, Castro MG. Quantification of high-capacity helper-dependent adenoviral vector genomes in vitro and in vivo, using quantitative TaqMan real-time polymerase chain reaction. Human Gene Therapy. 17: 531-44. PMID 16716110 DOI: 10.1089/hum.2006.17.531  1
2006 Zirger JM, Barcia C, Liu C, Puntel M, Mitchell N, Campbell I, Castro M, Lowenstein PR. Rapid upregulation of interferon-regulated and chemokine mRNAs upon injection of 108 international units, but not lower doses, of adenoviral vectors into the brain. Journal of Virology. 80: 5655-9. PMID 16699048 DOI: 10.1128/JVI.00166-06  1
2006 Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG. Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain. Journal of Immunology (Baltimore, Md. : 1950). 176: 3566-77. PMID 16517725  1
2006 Xiong W, Goverdhana S, Sciascia SA, Candolfi M, Zirger JM, Barcia C, Curtin JF, King GD, Jaita G, Liu C, Kroeger K, Agadjanian H, Medina-Kauwe L, Palmer D, Ng P, ... Lowenstein PR, et al. Regulatable gutless adenovirus vectors sustain inducible transgene expression in the brain in the presence of an immune response against adenoviruses. Journal of Virology. 80: 27-37. PMID 16352528 DOI: 10.1128/JVI.80.1.27-37.2006  1
2005 King GD, Curtin JF, Candolfi M, Kroeger K, Lowenstein PR, Castro MG. Gene therapy and targeted toxins for glioma. Current Gene Therapy. 5: 535-57. PMID 16457645 DOI: 10.2174/156652305774964631  1
2005 Torres EM, Monville C, Lowenstein PR, Castro MG, Dunnett SB. Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors Increased yield of dopamine cells is dependent on embryonic donor age. Brain Research Bulletin. 68: 31-41. PMID 16325002 DOI: 10.1016/j.brainresbull.2005.08.021  1
2005 Iannacone M, Sitia G, Isogawa M, Marchese P, Castro MG, Lowenstein PR, Chisari FV, Ruggeri ZM, Guidotti LG. Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nature Medicine. 11: 1167-9. PMID 16258538 DOI: 10.1038/nm1317  1
2005 Curtin JF, King GD, Candolfi M, Greeno RB, Kroeger KM, Lowenstein PR, Castro MG. Combining cytotoxic and immune-mediated gene therapy to treat brain tumors. Current Topics in Medicinal Chemistry. 5: 1151-70. PMID 16248789 DOI: 10.2174/156802605774370856  1
2005 Ali S, King GD, Curtin JF, Candolfi M, Xiong W, Liu C, Puntel M, Cheng Q, Prieto J, Ribas A, Kupiec-Weglinski J, van Rooijen N, Lassmann H, Lowenstein PR, Castro MG. Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model. Cancer Research. 65: 7194-204. PMID 16103070 DOI: 10.1158/0008-5472.CAN-04-3434  1
2005 Grande-Pérez A, Gómez-Mariano G, Lowenstein PR, Domingo E. Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. Journal of Virology. 79: 10451-9. PMID 16051837 DOI: 10.1128/JVI.79.16.10451-10459.2005  1
2005 Lowenstein PR. The case for immunosuppression in clinical gene transfer. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 185-6. PMID 16002339 DOI: 10.1016/j.ymthe.2005.06.439  1
2005 Abordo-Adesida E, Follenzi A, Barcia C, Sciascia S, Castro MG, Naldini L, Lowenstein PR. Stability of lentiviral vector-mediated transgene expression in the brain in the presence of systemic antivector immune responses. Human Gene Therapy. 16: 741-51. PMID 15960605 DOI: 10.1089/hum.2005.16.741  1
2005 Torres EM, Monville C, Lowenstein PR, Castro MG, Dunnett SB. In vivo transgene expression from an adenoviral vector is altered following a 6-OHDA lesion of the dopamine system. Brain Research. Molecular Brain Research. 137: 1-10. PMID 15950755 DOI: 10.1016/j.molbrainres.2004.10.046  1
2005 Goverdhana S, Puntel M, Xiong W, Zirger JM, Barcia C, Curtin JF, Soffer EB, Mondkar S, King GD, Hu J, Sciascia SA, Candolfi M, Greengold DS, Lowenstein PR, Castro MG. Regulatable gene expression systems for gene therapy applications: progress and future challenges. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 189-211. PMID 15946903 DOI: 10.1016/j.ymthe.2005.03.022  1
2005 Domingo E, Pariente N, Airaksinen A, Gonzaĺez-Lopez C, Sierra S, Herrera M, Grande-Pérez A, Lowenstein PR, Manrubia SC, Lázaro E, Escarmís C. Foot-and-mouth disease virus evolution: exploring pathways towards virus extinction. Current Topics in Microbiology and Immunology. 288: 149-73. PMID 15648178  1
2004 Suwelack D, Hurtado-Lorenzo A, Millan E, Gonzalez-Nicolini V, Wawrowsky K, Lowenstein PR, Castro MG. Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease. Gene Therapy. 11: 1742-52. PMID 15573088 DOI: 10.1038/sj.gt.3302377  1
2004 Ali S, Curtin JF, Zirger JM, Xiong W, King GD, Barcia C, Liu C, Puntel M, Goverdhana S, Lowenstein PR, Castro MG. Inflammatory and anti-glioma effects of an adenovirus expressing human soluble Fms-like tyrosine kinase 3 ligand (hsFlt3L): treatment with hsFlt3L inhibits intracranial glioma progression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 1071-84. PMID 15564139 DOI: 10.1016/j.ymthe.2004.08.025  1
2004 Biglari A, Bataille D, Naumann U, Weller M, Zirger J, Castro MG, Lowenstein PR. Effects of ectopic decorin in modulating intracranial glioma progression in vivo, in a rat syngeneic model. Cancer Gene Therapy. 11: 721-32. PMID 15475879 DOI: 10.1038/sj.cgt.7700783  1
2004 Hurtado-Lorenzo A, Millan E, Gonzalez-Nicolini V, Suwelack D, Castro MG, Lowenstein PR. Differentiation and transcription factor gene therapy in experimental parkinson's disease: sonic hedgehog and Gli-1, but not Nurr-1, protect nigrostriatal cell bodies from 6-OHDA-induced neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 507-24. PMID 15336651 DOI: 10.1016/j.ymthe.2004.05.021  1
2004 Lowenstein PR. Input virion proteins: cryptic targets of antivector immune responses in preimmunized subjects. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 771-4. PMID 15222326 DOI: 10.1016/j.ymthe.2004.05.019  1
2004 Dorigo O, Gil JS, Gallaher SD, Tan BT, Castro MG, Lowenstein PR, Calos MP, Berk AJ. Development of a novel helper-dependent adenovirus-Epstein-Barr virus hybrid system for the stable transformation of mammalian cells. Journal of Virology. 78: 6556-66. PMID 15163748 DOI: 10.1128/JVI.78.12.6556-6566.2004  1
2004 Lowenstein PR, Castro MG. Recent advances in the pharmacology of neurological gene therapy. Current Opinion in Pharmacology. 4: 91-7. PMID 15018845 DOI: 10.1016/j.coph.2003.10.005  1
2004 Ke B, Shen XD, Gao F, Busuttil RW, Löwenstein PR, Castro MG, Kupiec-Weglinski JW. Gene therapy for liver transplantation using adenoviral vectors: CD40-CD154 blockade by gene transfer of CD40Ig protects rat livers from cold ischemia and reperfusion injury. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 38-45. PMID 14741776  1
2004 Lowenstein PR. Immunological needles in the gene therapy haystack: applying a genetic paradigm to gene therapy. Gene Therapy. 11: 1-3. PMID 14681691 DOI: 10.1038/sj.gt.3302186  1
2003 Kingston PA, Sinha S, Appleby CE, David A, Verakis T, Castro MG, Lowenstein PR, Heagerty AM. Adenovirus-mediated gene transfer of transforming growth factor-beta3, but not transforming growth factor-beta1, inhibits constrictive remodeling and reduces luminal loss after coronary angioplasty. Circulation. 108: 2819-25. PMID 14638551 DOI: 10.1161/01.CIR.0000097068.49080.A0  1
2003 Lowenstein PR, Suwelack D, Hu J, Yuan X, Jimenez-Dalmaroni M, Goverdhana S, Castro MG. Nonneurotropic adenovirus: a vector for gene transfer to the brain and gene therapy of neurological disorders. International Review of Neurobiology. 55: 3-64. PMID 12968530 DOI: 10.1016/S0074-7742(03)01001-8  1
2003 Stone D, Xiong W, Williams JC, David A, Lowenstein PR, Castro MG. Adenovirus expression of IL-1 and NF-kappaB inhibitors does not inhibit acute adenoviral-induced brain inflammation, but delays immune system-mediated elimination of transgene expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 400-11. PMID 12946313 DOI: 10.1016/S1525-0016(03)00178-3  1
2003 Appleby CE, Kingston PA, David A, Gerdes CA, Umaña P, Castro MG, Lowenstein PR, Heagerty AM. A novel combination of promoter and enhancers increases transgene expression in vascular smooth muscle cells in vitro and coronary arteries in vivo after adenovirus-mediated gene transfer. Gene Therapy. 10: 1616-22. PMID 12907954 DOI: 10.1038/sj.gt.3302044  1
2003 Lowenstein PR, Castro MG. Inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences. Gene Therapy. 10: 946-54. PMID 12756415 DOI: 10.1038/sj.gt.3302048  1
2003 Lowenstein PR. Virology and immunology of gene therapy, or virology and immunology of high MOI infection with defective viruses. Gene Therapy. 10: 933-4. PMID 12756412 DOI: 10.1038/sj.gt.3302073  1
2003 Castro MG, Cowen R, Williamson IK, David A, Jimenez-Dalmaroni MJ, Yuan X, Bigliari A, Williams JC, Hu J, Lowenstein PR. Current and future strategies for the treatment of malignant brain tumors. Pharmacology & Therapeutics. 98: 71-108. PMID 12667889 DOI: 10.1016/S0163-7258(03)00014-7  1
2003 Hurtado-Lorenzo A, David A, Thomas C, Castro MG, Lowenstein PR. Use of recombinant adenovirus for gene transfer into the rat brain. Evaluation of gene transfer efficiency, toxicity, and inflammatory and immune reactions. Methods in Molecular Medicine. 76: 113-33. PMID 12526161  1
2003 Castro MG, Xiong W, Goverdhana S, Greengold D, Lowenstein PR. Gene therapy for pituitary tumors Endocrinologist. 13: 351-357. DOI: 10.1097/01.TEN.0000084309.68121.84  1
2002 Cowen RL, Williams JC, Emery S, Blakey D, Darling JL, Lowenstein PR, Castro MG. Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane. Cancer Gene Therapy. 9: 897-907. PMID 12386828 DOI: 10.1038/sj.cgt.7700514  1
2002 Lowenstein PR, Castro MG. Progress and challenges in viral vector-mediated gene transfer to the brain. Current Opinion in Molecular Therapeutics. 4: 359-71. PMID 12222874  1
2002 Grande-Pérez A, Sierra S, Castro MG, Domingo E, Lowenstein PR. Molecular indetermination in the transition to error catastrophe: systematic elimination of lymphocytic choriomeningitis virus through mutagenesis does not correlate linearly with large increases in mutant spectrum complexity. Proceedings of the National Academy of Sciences of the United States of America. 99: 12938-43. PMID 12215495 DOI: 10.1073/pnas.182426999  1
2002 Davis JR, McMahon RF, Lowenstein PR, Castro MG, Lincoln GA, McNeilly AS. Adenovirus-mediated gene transfer in the ovine pituitary gland is associated with hypophysitis. The Journal of Endocrinology. 173: 265-71. PMID 12010634 DOI: 10.1677/joe.0.1730265  1
2002 Pashenkov M, Link H, Lowenstein PR. Dendritic cells and immune responses in the central nervous system (multiple letters) Trends in Immunology. 23: 69-70. PMID 11929128 DOI: 10.1016/S1471-4906(01)02114-7  1
2002 Thomas CE, Edwards P, Wickham TJ, Castro MG, Lowenstein PR. Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types. Journal of Virology. 76: 3452-60. PMID 11884569 DOI: 10.1128/JVI.76.7.3452-3460.2002  1
2002 Lowenstein PR, Thomas CE, Umana P, Gerdes CA, Verakis T, Boyer O, Tondeur S, Klatzmann D, Castro MG. High-capacity, helper-dependent, "gutless" adenoviral vectors for gene transfer into brain. Methods in Enzymology. 346: 292-311. PMID 11883074 DOI: 10.1016/S0076-6879(02)46062-4  1
2002 Guillot C, Guillonneau C, Mathieu P, Gerdes CA, Ménoret S, Braudeau C, Tesson L, Renaudin K, Castro MG, Löwenstein PR, Anegon I. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection. Journal of Immunology (Baltimore, Md. : 1950). 168: 1600-9. PMID 11823487  1
2002 Lowenstein PR. Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary and developmental perspective. Trends in Immunology. 23: 23-30. PMID 11801451 DOI: 10.1016/S1471-4906(01)02063-4  1
2001 Thomas CE, Abordo-Adesida E, Maleniak TC, Stone D, Gerdes CA, Lowenstein PR. Gene transfer into rat brain using adenoviral vectors. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.24. PMID 18428484 DOI: 10.1002/0471142301.ns0424s13  1
2001 Williams JC, Stone D, Smith-Arica JR, Morris ID, Lowenstein PR, Castro MG. Regulated, adenovirus-mediated delivery of tyrosine hydroxylase suppresses growth of estrogen-induced pituitary prolactinomas. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 593-602. PMID 11735344 DOI: 10.1006/mthe.2001.0499  1
2001 Kingston PA, Sinha S, David A, Castro MG, Lowenstein PR, Heagerty AM. Adenovirus-mediated gene transfer of a secreted transforming growth factor-beta type II receptor inhibits luminal loss and constrictive remodeling after coronary angioplasty and enhances adventitial collagen deposition. Circulation. 104: 2595-601. PMID 11714656  1
2001 Zermansky AJ, Bolognani F, Stone D, Cowsill CM, Morrissey G, Castro MG, Löwenstein PR. Towards global and long-term neurological gene therapy: unexpected transgene dependent, high-level, and widespread distribution of HSV-1 thymidine kinase throughout the CNS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 490-8. PMID 11708886 DOI: 10.1006/mthe.2001.0479  1
2001 Castro MG, David A, Hurtado-Lorenzo A, Suwelack D, Millan E, Verakis T, Xiong WD, Yuan XP, Lowenstein PR. Gene therapy for Parkinson's disease: recent achievements and remaining challenges. Histology and Histopathology. 16: 1225-38. PMID 11642742  1
2001 Maleniak TC, Darling JL, Lowenstein PR, Castro MG. Adenovirus-mediated expression of HSV1-TK or Fas ligand induces cell death in primary human glioma-derived cell cultures that are resistant to the chemotherapeutic agent CCNU. Cancer Gene Therapy. 8: 589-98. PMID 11571537 DOI: 10.1038/sj.cgt.7700348  1
2001 Lowenstein PR, Castro MG. Genetic engineering within the adult brain: implications for molecular approaches to behavioral neuroscience. Physiology & Behavior. 73: 833-9. PMID 11566216 DOI: 10.1016/S0031-9384(01)00520-0  1
2001 Pariente N, Sierra S, Lowenstein PR, Domingo E. Efficient virus extinction by combinations of a mutagen and antiviral inhibitors. Journal of Virology. 75: 9723-30. PMID 11559805 DOI: 10.1128/JVI.75.20.9723-9730.2001  1
2001 Castro M, Hurtado-Lorenzo A, Umana P, Smith-Arica JR, Zermansky A, Abordo-Adesida E, Löwenstein PR. Regulatable and cell-type specific transgene expression in glial cells: prospects for gene therapy for neurological disorders. Progress in Brain Research. 132: 655-81. PMID 11545027 DOI: 10.1016/S0079-6123(01)32109-X  0.92
2001 Umaña P, Gerdes CA, Stone D, Davis JR, Ward D, Castro MG, Lowenstein PR. Efficient FLPe recombinase enables scalable production of helper-dependent adenoviral vectors with negligible helper-virus contamination. Nature Biotechnology. 19: 582-5. PMID 11385466 DOI: 10.1038/89349  1
2001 Smith-Arica JR, Williams JC, Stone D, Smith J, Lowenstein PR, Castro MG. Switching on and off transgene expression within lactotrophic cells in the anterior pituitary gland in vivo. Endocrinology. 142: 2521-32. PMID 11356701 DOI: 10.1210/endo.142.6.8183  1
2001 Thomas CE, Schiedner G, Kochanek S, Castro MG, Lowenstein PR. Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors. Human Gene Therapy. 12: 839-46. PMID 11339900 DOI: 10.1089/104303401750148829  1
2001 Glaser T, Castro MG, Löwenstein PR, Weller M. Death receptor-independent cytochrome c release and caspase activation mediate thymidine kinase plus ganciclovir-mediated cytotoxicity in LN-18 and LN-229 human malignant glioma cells. Gene Therapy. 8: 469-76. PMID 11313826 DOI: 10.1038/sj.gt.3301415  1
2001 Castro MG, Southgate T, Lowenstein PR. Molecular therapy in a model neuroendocrine disease: developing clinical gene therapy for pituitary tumours. Trends in Endocrinology and Metabolism: Tem. 12: 58-64. PMID 11167123  1
2001 Thomas CE, Birkett D, Anozie I, Castro MG, Lowenstein PR. Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 36-46. PMID 11162309 DOI: 10.1006/mthe.2000.0224  1
2001 Davis JR, McVerry J, Lincoln GA, Windeatt S, Lowenstein PR, Castro MG, McNeilly AS. Cell type-specific adenoviral transgene expression in the intact ovine pituitary gland after stereotaxic delivery: an in vivo system for long-term multiple parameter evaluation of human pituitary gene therapy. Endocrinology. 142: 795-801. PMID 11159852 DOI: 10.1210/endo.142.2.7963  1
2001 Southgate TD, Stone D, Williams JC, Lowenstein PR, Castro MG. Long-term transgene expression within the anterior pituitary gland in situ: impact on circulating hormone levels, cellular and antibody-mediated immune responses. Endocrinology. 142: 464-76. PMID 11145611 DOI: 10.1210/endo.142.1.7898  1
2000 Lowenstein PR. Un pour tous, tous pour un. Trends in Neurosciences. 23: 467-8. PMID 11203140  1
2000 Brown O, Cowen RL, Preston CM, Castro MG, Lowenstein PR. Subcellular post-transcriptional targeting: delivery of an intracellular protein to the extracellular leaflet of the plasma membrane using a glycosyl-phosphatidylinositol (GPI) membrane anchor in neurons and polarised epithelial cells. Gene Therapy. 7: 1947-53. PMID 11127583 DOI: 10.1038/sj.gt.3301325  1
2000 Smith-Arica JR, Morelli AE, Larregina AT, Smith J, Lowenstein PR, Castro MG. Cell-type-specific and regulatable transgenesis in the adult brain: adenovirus-encoded combined transcriptional targeting and inducible transgene expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 2: 579-87. PMID 11124058 DOI: 10.1006/mthe.2000.0215  1
2000 Gerdes CA, Castro MG, Löwenstein PR. Strong promoters are the key to highly efficient, noninflammatory and noncytotoxic adenoviral-mediated transgene delivery into the brain in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 2: 330-8. PMID 11020348 DOI: 10.1006/mthe.2000.0140  1
2000 Castro MG, Cowen R, Smith-Arica J, Williams J, Ali S, Windeatt S, Gonzalez-Nicolini V, Maleniak T, Lowenstein PR. Gene therapy strategies for intracranial tumours: glioma and pituitary adenomas. Histology and Histopathology. 15: 1233-52. PMID 11005248  1
2000 Southgate TD, Windeatt S, Smith-Arica J, Gerdes CA, Perone MJ, Morris I, Davis JR, Klatzmann D, Löwenstein PR, Castro MG. Transcriptional targeting to anterior pituitary lactotrophic cells using recombinant adenovirus vectors in vitro and in vivo in normal and estrogen/sulpiride-induced hyperplastic anterior pituitaries. Endocrinology. 141: 3493-505. PMID 10965923 DOI: 10.1210/endo.141.9.7639  1
2000 Sierra S, Dávila M, Lowenstein PR, Domingo E. Response of foot-and-mouth disease virus to increased mutagenesis: influence of viral load and fitness in loss of infectivity. Journal of Virology. 74: 8316-23. PMID 10954530 DOI: 10.1128/JVI.74.18.8316-8323.2000  1
2000 Thomas CE, Schiedner G, Kochanek S, Castro MG, Löwenstein PR. Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: toward realistic long-term neurological gene therapy for chronic diseases. Proceedings of the National Academy of Sciences of the United States of America. 97: 7482-7. PMID 10840055 DOI: 10.1073/pnas.120474397  1
2000 Turvey SE, Gonzalez-Nicolini V, Kingsley CI, Larregina AT, Morris PJ, Castro MG, Lowenstein PR, Wood KJ. Fas ligand-transfected myoblasts and islet cell transplantation. Transplantation. 69: 1972-6. PMID 10830245  1
2000 Cowsill C, Southgate TD, Morrissey G, Dewey RA, Morelli AE, Maleniak TC, Forrest Z, Klatzmann D, Wilkinson GW, Löwenstein PR, Castro MG. Central nervous system toxicity of two adenoviral vectors encoding variants of the herpes simplex virus type 1 thymidine kinase: reduced cytotoxicity of a truncated HSV1-TK. Gene Therapy. 7: 679-85. PMID 10800091 DOI: 10.1038/sj.gt.3301147  1
2000 Guillot C, Mathieu P, Coathalem H, Le Mauff B, Castro MG, Tesson L, Usal C, Laumonier T, Brouard S, Soulillou JP, Lowenstein PR, Cuturi MC, Anegon I. Tolerance to cardiac allografts via local and systemic mechanisms after adenovirus-mediated CTLA4Ig expression. Journal of Immunology (Baltimore, Md. : 1950). 164: 5258-68. PMID 10799887  1
2000 Windeatt S, Southgate TD, Dewey RA, Bolognani F, Perone MJ, Larregina AT, Maleniak TC, Morris ID, Goya RG, Klatzmann D, Löwenstein PR, Castro MG. Adenovirus-mediated herpes simplex virus type-1 thymidine kinase gene therapy suppresses oestrogen-induced pituitary prolactinomas. The Journal of Clinical Endocrinology and Metabolism. 85: 1296-305. PMID 10720079 DOI: 10.1210/jcem.85.3.6482  1
2000 Stone D, David A, Bolognani F, Lowenstein PR, Castro MG. Viral vectors for gene delivery and gene therapy within the endocrine system. The Journal of Endocrinology. 164: 103-18. PMID 10657846  1
1999 Castro MG, Davis JR, Xiong W, Lowenstein PR. Recent developments in gene therapy: applications for the treatment of pituitary tumours. BaillièRe's Best Practice & Research. Clinical Endocrinology & Metabolism. 13: 431-49. PMID 10909434 DOI: 10.1053/beem.1999.0035  1
1999 Southgate TD, Bain D, Fairbanks LD, Morelli AE, Larregina AT, Simmonds HA, Castro MG, Löwenstein PR. Adenoviruses encoding HPRT correct biochemical abnormalities of HPRT-deficient cells and allow their survival in negative selection medium. Metabolic Brain Disease. 14: 205-21. PMID 10850548  1
1999 Lowenstein PR, Cowen R, Thomas C, Castro MG. The basic science of brain-tumour gene therapy. Biochemical Society Transactions. 27: 873-81. PMID 10830120  1
1999 Castro MG, Windeatt S, Smith-Arica J, Lowenstein PR. Cell-type specific expression in the pituitary: physiology and gene therapy. Biochemical Society Transactions. 27: 858-63. PMID 10830117  1
1999 Davis JR, Lowenstein PR, McNeilly AS, Castro MG. Gene therapy for pituitary tumours. Endocrine-Related Cancer. 6: 475-81. PMID 10730901  1
1999 Tomasec P, Preston CM, Linton EA, Ahmed I, Lowenstein PR, Castro MG. Generation of a recombinant herpes simplex virus type 1 expressing the rat corticotropin- releasing hormone precursor: endoproteolytic processing, intracellular targeting and biological activity. Neuroendocrinology. 70: 439-50. PMID 10657737  1
1999 Dewey RA, Morrissey G, Cowsill CM, Stone D, Bolognani F, Dodd NJ, Southgate TD, Klatzmann D, Lassmann H, Castro MG, Löwenstein PR. Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials. Nature Medicine. 5: 1256-63. PMID 10545991 DOI: 10.1038/15207  1
1999 Lowenstein PR, Thomas CE, Castro MG. Politically correct gene therapy? A "clean environment" improves gene delivery to the brain! Gene Therapy. 6: 463-4. PMID 10476205 DOI: 10.1038/sj.gt.3300917  1
1999 Ambar BB, Frei K, Malipiero U, Morelli AE, Castro MG, Lowenstein PR, Fontana A. Treatment of experimental glioma by administration of adenoviral vectors expressing Fas ligand. Human Gene Therapy. 10: 1641-8. PMID 10428209 DOI: 10.1089/10430349950017644  1
1999 Morelli AE, Larregina AT, Smith-Arica J, Dewey RA, Southgate TD, Ambar B, Fontana A, Castro MG, Lowenstein PR. Neuronal and glial cell type-specific promoters within adenovirus recombinants restrict the expression of the apoptosis-inducing molecule Fas ligand to predetermined brain cell types, and abolish peripheral liver toxicity. The Journal of General Virology. 80: 571-83. PMID 10091995  1
1999 Cartmell T, Southgate T, Rees GS, Castro MG, Lowenstein PR, Luheshi GN. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1517-23. PMID 9952427  1
1999 Kingston PA, Castro MG, Arrand JR, Lowenstein PR, Heagerty AM. A recombinant adenovirus vector expressing Transforming Growth Factor-β3 gives rise to high level expression of TGF-β3 in cultured vascular smooth muscle cells: Potential gene therapy for restenosis Heart. 81: P57.  1
1998 Lowenstein PR, Southgate TD, Smith-Arica JR, Smith J, Castro MG. Gene therapy for inherited neurological disorders: towards therapeutic intervention in the Lesch-Nyhan syndrome. Progress in Brain Research. 117: 485-501. PMID 9932427  1
1998 Perone MJ, Murray CA, Brown OA, Gibson S, White A, Linton EA, Perkins AV, Lowenstein PR, Castro MG. Procorticotrophin-releasing hormone: endoproteolytic processing and differential release of its derived peptides within AtT20 cells. Molecular and Cellular Endocrinology. 142: 191-202. PMID 9783915 DOI: 10.1016/S0303-7207(98)00104-X  1
1998 Perone MJ, Windeatt S, Morrison E, Shering A, Tomasec P, Linton E, Lowenstein PR, Castro MG. Intracellular retention of the corticotrophin-releasing hormone (CRH) precursor within COS-7 cells. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 46: 1193-7. PMID 9742076  1
1998 Goya RG, Rowe J, Sosa YE, Tomasec P, Lowenstein PR, Castro MG. Use of recombinant herpes simplex virus type 1 vectors for gene transfer into tumour and normal anterior pituitary cells. Molecular and Cellular Endocrinology. 139: 199-207. PMID 9705088 DOI: 10.1016/S0303-7207(98)00059-8  1
1998 Cahusac PM, Castro MG, Robertson L, Lowenstein PR. Electrophysiological evidence against a neurotransmitter role of corticotropin-releasing hormone (CRH) in primary somatosensory cortex. Brain Research. 793: 73-8. PMID 9630525 DOI: 10.1016/S0006-8993(98)00162-0  1
1998 Larregina AT, Morelli AE, Dewey RA, Castro MG, Fontana A, Lowenstein PR. FasL induces Fas/Apo1-mediated apoptosis in human embryonic kidney 293 cells routinely used to generate E1-deleted adenoviral vectors. Gene Therapy. 5: 563-8. PMID 9614583 DOI: 10.1038/sj.gt.3300615  1
1997 Lowenstein PR. Why are we doing so much cancer gene therapy? Disentangling the scientific basis from the origins of gene therapy. Gene Therapy. 4: 755-6. PMID 9338001 DOI: 10.1038/sj.gt.3300494  1
1997 Brown OA, Santer RM, Shering AF, Larregina AT, Morelli AE, Southgate TD, Castro MG, Lowenstein PR. Gene transfer into enteric neurons of the rat small intestine in organ culture using a replication defective recombinant herpes simplex virus type 1 (HSV1) vector, but not recombinant adenovirus vectors. Gene Therapy. 4: 331-8. PMID 9176519 DOI: 10.1038/sj.gt.3300383  1
1997 Castro MG, Goya RG, Sosa YE, Rowe J, Larregina A, Morelli A, Lowenstein PR. Expression of transgenes in normal and neoplastic anterior pituitary cells using recombinant adenoviruses: long term expression, cell cycle dependency, and effects on hormone secretion. Endocrinology. 138: 2184-94. PMID 9112418 DOI: 10.1210/endo.138.5.5134  1
1997 Stewart K, Brown OA, Morelli AE, Fairbairn LJ, Lashford LS, Cooper A, Hatton CE, Dexter TM, Castro MG, Lowenstein PR. Uptake of alpha-(L)-iduronidase produced by retrovirally transduced fibroblasts into neuronal and glial cells in vitro. Gene Therapy. 4: 63-75. PMID 9068797 DOI: 10.1038/sj.gt.3300364  1
1997 Shering AF, Bain D, Stewart K, Epstein AL, Castro MG, Wilkinson GW, Lowenstein PR. Cell type-specific expression in brain cell cultures from a short human cytomegalovirus major immediate early promoter depends on whether it is inserted into herpesvirus or adenovirus vectors. The Journal of General Virology. 78: 445-59. PMID 9018068  1
1996 Wood JD, MacMillan JC, Harper PS, Lowenstein PR, Jones AL. Partial characterisation of murine huntingtin and apparent variations in the subcellular localisation of huntingtin in human, mouse and rat brain. Human Molecular Genetics. 5: 481-7. PMID 8845840 DOI: 10.1093/hmg/5.4.481  1
1996 Castro MG, Morrison E, Perone MJ, Brown OA, Murray CA, Ahmed I, Perkins AV, Europe-Finner G, Lowenstein PR, Linton EA. Corticotrophin-releasing hormone receptor type 1: generation and characterization of polyclonal antipeptide antibodies and their localization in pituitary cells and cortical neurones in vitro. Journal of Neuroendocrinology. 8: 521-31. PMID 8843021 DOI: 10.1046/j.1365-2826.1996.04866.x  1
1995 Lowenstein PR, Bain D, Shering AF, Wilkinson GW, Castro MG. Cell type-specific expression from viral promoters within replication-deficient adenovirus recombinants in primary neocortical cultures. Restorative Neurology and Neuroscience. 8: 37-9. PMID 21551803 DOI: 10.3233/RNN-1995-81209  1
1995 Lowenstein PR. Degenerative and inherited neurological disorders. Molecular and Cell Biology of Human Diseases Series. 5: 307-49. PMID 9532573  1
1995 Bevilacqua JA, Downes CP, Lowenstein PR. Transiently selective activation of phosphoinositide turnover in layer V pyramidal neurons after specific mGluRs stimulation in rat somatosensory cortex during early postnatal development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 15: 7916-28. PMID 8613730  1
1995 Castro MG, Rowe JM, Murray CA, Tomasec P, Shering AF, Linton EA, Ahmed I, Lowenstein PR. Generation and characterization of an antiserum reactive with a proteolytic processing site within rat procorticotrophin-releasing hormone. Neuropeptides. 29: 183-92. PMID 8584136 DOI: 10.1016/0143-4179(95)90060-8  1
1995 Castro MG, Morrison E, Tomasec P, Linton EA, Lowenstein PR. Co-localisation of autoimmune antibodies specific for double stranded DNA with procorticotrophin-releasing hormone within the nucleus of stably transfected CHO-K1 cells. Cell and Tissue Research. 282: 367-76. PMID 8581931 DOI: 10.1007/BF00318869  1
1995 Castrol MG, Tomasec P, Morrison E, Murray CA, Hodge P, Blanning P, Linton E, Lowry PJ, Lowenstein PR. Mitogenic effects and nuclear localisation of procorticotrophin-releasing hormone expressed within stably transfected fibroblast cells (CHO-K1). Molecular and Cellular Endocrinology. 107: 17-27. PMID 7796932 DOI: 10.1016/0303-7207(94)03416-Q  1
1995 Lowenstein PR, Shering AF, MacDougall LK, Cohen P. Immunolocalisation of protein phosphatase inhibitor-1 in the cerebral cortex of the rat, cat and ferret. Brain Research. 676: 80-92. PMID 7796181 DOI: 10.1016/0006-8993(95)00091-4  1
1995 Morrison E, Tomasec P, Linton EA, Lowry PJ, Lowenstein PR, Castro MG. Expression of biologically active procorticotrophin-releasing hormone (proCRH) in stably transfected CHO-K1 cells: characterization of nuclear proCRH. Journal of Neuroendocrinology. 7: 263-72. PMID 7647768 DOI: 10.1111/j.1365-2826.1995.tb00756.x  1
1995 Lowenstein PR, Shering AF, Morrison E, Tomasec P, Bain D, Jacob TJ, Wu J, Prescott A, Castro MG. Synaptogenesis and distribution of presynaptic axonal varicosities in low density primary cultures of neocortex: an immunocytochemical study utilizing synaptic vesicle-specific antibodies, and an electrophysiological examination utilizing whole cell recording. Journal of Neurocytology. 24: 301-17. PMID 7643134  1
1995 Lowenstein PR, Fournel S, Bain D, Tomasec P, Clissold PM, Castro MG, Epstein AL. Simultaneous detection of amplicon and HSV-1 helper encoded proteins reveals that neurons and astrocytoma cells do express amplicon-borne transgenes in the absence of synthesis of virus immediate early proteins. Brain Research. Molecular Brain Research. 30: 169-75. PMID 7609639  1
1994 Bevilacqua JA, Bain D, Downes CP, Lowenstein PR. Visualization of receptor coupled phosphoinositide turnover in single neurons and a glial cell line in culture. Gene Therapy. 1: S69. PMID 8542415  0.52
1994 Bain D, Wilkinson GW, Preston CM, Castro MG, Lowenstein PR. Adenovirus vectors to transfer genes into neurones: implications for gene therapy of neurological disorders. Gene Therapy. 1: S68. PMID 8542414  1
1994 Tomasec P, Lowenstein PR, Morrison E, Hodge P, Linton EA, Perkins A, Lowry PJ, Castro MG. Use of gene transfer to study post-translational modifications of neuropeptides in cell lines. Gene Therapy. 1: S64. PMID 8542410  1
1994 Morrison E, Lowenstein PR, Hodge P, Linton E, Lowry PJ, Corredoira Y, Castro MG. Nuclear and cytoplasmic localisation of procorticotrophin releasing hormone in transfected CHO-K1 cells. Gene Therapy. 1: S62. PMID 8542408  1
1994 Lowenstein PR, Bain D, Morrison EE, Preston CM, Clissold P, Fournel S, Epstein A, Castro MG. HSV1 vectors to study protein targeting in neurones: are glycosyl-phosphatidylinositol anchors polarized targeting signals in neurones? Gene Therapy. 1: S32-5. PMID 8542390  1
1994 Castro MG, Hodge P, Corredoira YA, Morrison E, Tomasec P, Murray CA, Lowenstein PR. Neuropeptide gene transfer into neuronal and glial cell lines. Gene Therapy. 1: S15-8. PMID 8542384  1
1994 Wilkinson GW, Lowenstein PR. Introduction to gene transfer: viral vectors. Gene Therapy. 1: S1-3. PMID 8542380  1
1994 Lowenstein PR, Morrison EE, Bain D, Shering AF, Banting G, Douglas P, Castro MG. Polarized distribution of the trans-Golgi network marker TGN38 during the in vitro development of neocortical neurons: effects of nocodazole and brefeldin A. The European Journal of Neuroscience. 6: 1453-65. PMID 8000569  1
1994 Lowenstein PR, Morrison EE, Bain D, Hodge P, Preston CM, Clissold P, Stow ND, McKee TA, Castro MG. Use of recombinant vectors derived from herpes simplex virus 1 mutant tsK for short-term expression of transgenes encoding cytoplasmic and membrane anchored proteins in postmitotic polarized cortical neurons and glial cells in vitro. Neuroscience. 60: 1059-77. PMID 7936206 DOI: 10.1016/0306-4522(94)90283-6  1
1994 Reynolds DJ, Lowenstein PR, Moorman JM, Grahame-Smith DG, Leslie RA. Evidence for cholinergic vagal afferents and vagal presynaptic M1 receptors in the ferret. Neurochemistry International. 25: 455-64. PMID 7849574 DOI: 10.1016/0197-0186(94)90022-1  1
1994 Shering AF, Lowenstein PR. Neocortex provides direct synaptic input to interstitial neurons of the intermediate zone of kittens and white matter of cats: a light and electron microscopic study. The Journal of Comparative Neurology. 347: 433-43. PMID 7822492 DOI: 10.1002/cne.903470309  0.64
1994 Lowenstein PR, Fournel S, Bain D, Tomasec P, Clissold P, Castro MG, Epstein AL. Herpes simplex virus 1 (HSV-1) helper co-infection affects the distribution of an amplicon encoded protein in glia. Neuroreport. 5: 1625-30. PMID 7819534  1
1993 Ringan NS, Grayson L, Lowenstein PR, Linton EA, Lowry PJ, Castro MG. Prediction of protein antigenic sites in human corticotrophin-releasing hormone precursor. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 104: 521-9. PMID 8482078 DOI: 10.1016/0305-0491(93)90277-C  1
1993 Morrison E, Lowenstein PR, Tomasec P, Hodge P, Linton E, Devine J, Lowry PJ, Castro MG. Intracellular compartmentalisation of procorticotrophin releasing hormone. Biochemical Society Transactions. 21: 47S. PMID 8449331  1
1993 Lowenstein PR, Morrison E, Hodge P, Tomasec P, Shering AF, Stow ND, Preston CM, James JL, Castro MG. Polarity development and synaptogenesis in low density primary cultures of neocortex. Use of herpes simplex virus-1 vectors to transfer genes into postmitotic neurons. Biochemical Society Transactions. 21: 14S. PMID 8383604  1
1993 Lowenstein PR, Morrison E, Douglas P, Preston CM, Clissold P, Banting G, Stow ND, Castro MG. Neocortical neuronal polarity: targeting of a foreign protein linked to a glycosyl-phosphatidylinositol (GPI) anchor in postmitotic neurons and polarized distribution of a marker of the trans-Golgi network (TGN 38). Biochemical Society Transactions. 21: 117S. PMID 8359373  1
1993 Morrison E, Hodge P, Tomasec P, Lowenstein PR, Linton EA, Lowry PJ, Castro MG. Nuclear localisation of corticotrophin releasing hormone (CRH) in transfected CHO-K1 cells. Biochemical Society Transactions. 21: 318S. PMID 8224463  1
1992 Castro MG, Lowry PJ, Lowenstein PR. Antibodies to neuropeptide precursors expressed as fusion proteins in E. coli. Their use to examine neuropeptide biosynthetic pathways, intracellular trafficking and physiological activities. The International Journal of Biochemistry. 24: 847-60. PMID 1612176  1
1991 Lowenstein PR, Somogyi P. Synaptic organization of cortico-cortical connections from the primary visual cortex to the posteromedial lateral suprasylvian visual area in the cat. The Journal of Comparative Neurology. 310: 253-66. PMID 1955584 DOI: 10.1002/cne.903100209  1
1990 Lowenstein PR, Joyce JN, Coyle JT, Marshall JF. Striosomal organization of cholinergic and dopaminergic uptake sites and cholinergic M1 receptors in the adult human striatum: a quantitative receptor autoradiographic study. Brain Research. 510: 122-6. PMID 2322836 DOI: 10.1016/0006-8993(90)90736-U  1
1990 Castro MG, Lowenstein PR, Saphier PW, Linton EA, Lowry PJ. The use of inclusion bodies, isolated from Escherichia coli expressing corticotrophin-releasing hormone precursor, to raise specific antibodies against the neuropeptide moiety. Journal of Molecular Endocrinology. 5: 221-30. PMID 2126928  1
1989 Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Raskin LS, Price DL, Coyle JT. Compartment-specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: a quantitative receptor autoradiographic study. The Journal of Comparative Neurology. 288: 428-46. PMID 2794143 DOI: 10.1002/cne.902880306  1
1988 Saltarelli MD, Lopez J, Lowenstein PR, Coyle JT. The role of calcium in the regulation of [3H]hemicholinium-3 binding sites in rat brain. Neuropharmacology. 27: 1301-8. PMID 3149725 DOI: 10.1016/0028-3908(88)90034-2  1
1988 Slesinger PA, Lowenstein PR, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT. Development of beta 1 and beta 2 adrenergic receptors in baboon brain: an autoradiographic study using [125I]iodocyanopindolol. The Journal of Comparative Neurology. 273: 318-29. PMID 2850303 DOI: 10.1002/cne.902730304  1
1987 Lowenstein PR, Slesinger PA, Singer HS, Walker LC, Casanova MF, Price DL, Coyle JT. An autoradiographic study of the development of [3H]hemicholinium-3 binding sites in human and baboon basal ganglia: a marker for the sodium-dependent high affinity choline uptake system. Brain Research. 431: 291-7. PMID 3620993 DOI: 10.1016/0165-3806(87)90216-1  1
1987 Saltarelli MD, Lowenstein PR, Coyle JT. Rapid in vitro modulation of [3H]hemicholinium-3 binding sites in rat striatal slices. European Journal of Pharmacology. 135: 35-40. PMID 3569424 DOI: 10.1016/0014-2999(87)90754-0  1
1986 Whitehouse PJ, Martino AM, Antuono PG, Lowenstein PR, Coyle JT, Price DL, Kellar KJ. Nicotinic acetylcholine binding sites in Alzheimer's disease. Brain Research. 371: 146-51. PMID 3708340 DOI: 10.1016/0006-8993(86)90819-X  1
1986 Cardinali DP, Lowenstein PR, Rosenstein RE, Gonzalez Solveyra C, Sarmiento MI, Romeo HE, Acuña Castroviejo D. Functional links between benzodiazepine and GABA receptors and pineal activity. Advances in Biochemical Psychopharmacology. 42: 155-64. PMID 3020894  1
1986 Acuña-Castroviejo D, Lowenstein PR, Rosenstein R, Cardinali DP. Diurnal variations of benzodiazepine binding in rat cerebral cortex: disruption by pinealectomy. Journal of Pineal Research. 3: 101-9. PMID 3014109  1
1985 Lowenstein PR, Rosenstein R, Cardinali DP. Melatonin reverses pinealectomy-induced decrease of benzodiazepine binding in rat cerebral cortex. Neurochemistry International. 7: 675-81. PMID 20492974  1
1985 Lowenstein PR, González Solveyra C, Keller Sarmiento MI, Cardinali DP. Benzodiazepines decrease norepinephrine release from rat pineal nerves by acting on peripheral type binding sites. Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La AsociacióN Latinoamericana De Ciencias FisiolóGicas Y De La AsociacióN Latinoamericana De FarmacologíA. 35: 441-9. PMID 2940804  1
1984 Lowenstein PR, Pereyra EN, González Solveyra C, Cardinali DP. Effect of naloxone on the nocturnal rise of rat pineal melatonin content. European Journal of Pharmacology. 98: 261-4. PMID 6714307  1
1984 Lowenstein PR, González Solveyra C, Cardinali DP. In vitro uptake of benzodiazepines by rat pineal gland. Journal of Pineal Research. 1: 207-13. PMID 6100721  1
1984 Lowenstein PR, González Solveyra C, Cardinali DP. Micromolar benzodiazepine binding sites of central type characteristics are present in the cerebral cortex of the rat. Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La AsociacióN Latinoamericana De Ciencias FisiolóGicas Y De La AsociacióN Latinoamericana De FarmacologíA. 34: 441-3. PMID 6100415  1
1984 Lowenstein PR, Rosenstein R, Caputti E, Cardinali DP. Benzodiazepine binding sites in human pineal gland. European Journal of Pharmacology. 106: 399-403. PMID 6099276  1
1983 Lowenstein PR, Cardinali DP. Characterization of flunitrazepam and beta-carboline high affinity binding in bovine pineal gland. Neuroendocrinology. 37: 150-4. PMID 6136930  1
1982 Lowenstein PR, Cardinali DP. Benzodiazepine receptor sites in bovine pineal. European Journal of Pharmacology. 86: 287-9. PMID 6297935  1
1982 Lowenstein PR, Vacas MI, Cardinali DP. Effect of pentoxifylline on alpha- and beta-adrenoceptor sites in cerebral cortex medial basal hypothalamus and pineal gland of the rat. Neuropharmacology. 21: 243-8. PMID 6280095 DOI: 10.1016/0028-3908(82)90194-0  1
1982 Vacas MI, Lowenstein PR, Cardinali DP. Testosterone decreases beta-adrenoceptor sites in rat pineal gland and brain. Journal of Neural Transmission. 53: 49-57. PMID 6278075 DOI: 10.1007/BF01243519  1
1980 Vacas MI, Lowenstein PR, Cardinali DP. Dihydroergocryptine binding sites in bovine and rat pineal glands. Journal of the Autonomic Nervous System. 2: 305-13. PMID 6265538 DOI: 10.1016/0165-1838(80)90029-6  1
1979 Vacas MI, Lowenstein PR, Cardinali DP. Characterization of a cytosol progesterone receptor in bovine pineal gland. Neuroendocrinology. 29: 84-9. PMID 503284 DOI: 10.1159/000122909  1
1979 Cardinali DP, Vacas MI, Lowenstein PR, Estévez E. [Neurohumoral control of the pineal gland. A model for the study of neuroendocrine integrative processes]. Acta Physiologica Latino Americana. 29: 291-304. PMID 45453  1
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