| Year |
Citation |
Score |
| 2020 |
Vekariya RH, Lei W, Ray A, Sainai SK, Zhang S, Molnar G, Barlow D, Karlage KL, Bilsky E, Houseknecht K, Largent-Milnes TM, Streicher JM, Ananthan S. Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a Mu Opioid Receptor Agonist/Delta Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects. Journal of Medicinal Chemistry. PMID 32530286 DOI: 10.1021/Acs.Jmedchem.0C00503 |
0.706 |
|
| 2020 |
Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ. Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration. Psychopharmacology. PMID 31912192 DOI: 10.1007/S00213-019-05449-Z |
0.433 |
|
| 2017 |
Streicher JM, Bilsky EJ. Peripherally Acting µ-Opioid Receptor Antagonists for the Treatment of Opioid-Related Side Effects: Mechanism of Action and Clinical Implications. Journal of Pharmacy Practice. 897190017732263. PMID 28946783 DOI: 10.1177/0897190017732263 |
0.635 |
|
| 2017 |
McLane VD, Bergquist I, Cormier J, Barlow DJ, Houseknecht KL, Bilsky EJ, Cao L. Long-term morphine delivery via slow release morphine pellets or osmotic pumps: Plasma concentration, analgesia, and naloxone-precipitated withdrawal. Life Sciences. PMID 28723417 DOI: 10.1016/j.lfs.2017.07.016 |
0.455 |
|
| 2017 |
Lei W, Mullen N, McCarthy S, Brann C, Richard P, Cormier J, Edwards K, Bilsky EJ, Streicher JM. Heat shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK Mitogen Activated Protein Kinase (MAPK) mechanism in mouse brain. The Journal of Biological Chemistry. PMID 28450396 DOI: 10.1074/Jbc.M116.769489 |
0.513 |
|
| 2015 |
Zhang Y, Williams DA, Zaidi SA, Yuan Y, Braithwaite A, Bilsky EJ, Dewey WL, Akbarali HI, Streicher JM, Selley DE. 17-Cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-(4'-pyridylcarboxamido)morphinan (NAP) modulating the mu opioid receptor in a biased fashion. Acs Chemical Neuroscience. PMID 26716358 DOI: 10.1021/Acschemneuro.5B00245 |
0.454 |
|
| 2015 |
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Structural Requirements for CNS Active Opioid Glycopeptides. Journal of Medicinal Chemistry. 58: 5728-41. PMID 26125201 DOI: 10.1021/Acs.Jmedchem.5B00014 |
0.497 |
|
| 2015 |
Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacology, Biochemistry, and Behavior. 132: 49-55. PMID 25735493 DOI: 10.1016/J.Pbb.2015.02.022 |
0.559 |
|
| 2014 |
Zhang Y, Braithwaite A, Yuan Y, Streicher JM, Bilsky EJ. Behavioral and cellular pharmacology characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan (NAQ) as a mu opioid receptor selective ligand. European Journal of Pharmacology. 736: 124-30. PMID 24815322 DOI: 10.1016/J.Ejphar.2014.04.041 |
0.665 |
|
| 2014 |
Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to β-endorphin? Journal of Medicinal Chemistry. 57: 2237-46. PMID 24576160 DOI: 10.1021/Jm400879W |
0.476 |
|
| 2013 |
Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain. Life Sciences. 93: 1010-6. PMID 24084045 DOI: 10.1016/J.Lfs.2013.09.016 |
0.606 |
|
| 2012 |
Ananthan S, Saini SK, Dersch CM, Xu H, McGlinchey N, Giuvelis D, Bilsky EJ, Rothman RB. 14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects. Journal of Medicinal Chemistry. 55: 8350-63. PMID 23016952 DOI: 10.1021/jm300686p |
0.557 |
|
| 2012 |
Yuan Y, Stevens DL, Braithwaite A, Scoggins KL, Bilsky EJ, Akbarali HI, Dewey WL, Zhang Y. 6β-N-heterocyclic substituted naltrexamine derivative NAP as a potential lead to develop peripheral mu opioid receptor selective antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 4731-4. PMID 22683223 DOI: 10.1016/J.Bmcl.2012.05.075 |
0.609 |
|
| 2012 |
Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R. Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins. Future Medicinal Chemistry. 4: 205-26. PMID 22300099 DOI: 10.4155/Fmc.11.195 |
0.435 |
|
| 2011 |
Yancey-Wrona J, Dallaire B, Bilsky E, Bath B, Burkart J, Webster L, Magiera D, Yang X, Phelps M, Sadee W. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Medicine (Malden, Mass.). 12: 1727-37. PMID 22123184 DOI: 10.1111/j.1526-4637.2011.01279.x |
0.609 |
|
| 2011 |
Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments. Chemical Biology & Drug Design. 78: 749-56. PMID 21801311 DOI: 10.1111/J.1747-0285.2011.01203.X |
0.351 |
|
| 2011 |
Reynolds J, Bilsky EJ, Meng ID. Selective ablation of mu-opioid receptor expressing neurons in the rostral ventromedial medulla attenuates stress-induced mechanical hypersensitivity. Life Sciences. 89: 313-9. PMID 21763327 DOI: 10.1016/j.lfs.2011.06.024 |
0.341 |
|
| 2011 |
Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. In vivo characterization of MMP-2200, a mixed δ/μ opioid agonist, in mice. The Journal of Pharmacology and Experimental Therapeutics. 336: 767-78. PMID 21118955 DOI: 10.1124/Jpet.110.172866 |
0.616 |
|
| 2010 |
Bilsky EJ, Giuvelis D, Osborn MD, Dersch CM, Xu H, Rothman RB. In vitro and in vivo assessment of mu opioid receptor constitutive activity. Methods in Enzymology. 484: 413-43. PMID 21036244 DOI: 10.1016/B978-0-12-381298-8.00021-6 |
0.581 |
|
| 2010 |
Osborn MD, Lowery JJ, Skorput AG, Giuvelis D, Bilsky EJ. In vivo characterization of the opioid antagonist nalmefene in mice. Life Sciences. 86: 624-30. PMID 20159022 DOI: 10.1016/j.lfs.2010.02.013 |
0.576 |
|
| 2010 |
Sally EJ, Xu H, Dersch CM, Hsin LW, Chang LT, Prisinzano TE, Simpson DS, Giuvelis D, Rice KC, Jacobson AE, Cheng K, Bilsky EJ, Rothman RB. Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor. Synapse (New York, N.Y.). 64: 280-8. PMID 19953652 DOI: 10.1002/Syn.20723 |
0.577 |
|
| 2009 |
Yancey-Wrona JE, Raymond TJ, Mercer HK, Sadée W, Bilsky EJ. 6beta-naltrexol preferentially antagonizes opioid effects on gastrointestinal transit compared to antinociception in mice. Life Sciences. 85: 413-20. PMID 19583969 DOI: 10.1016/j.lfs.2009.06.016 |
0.562 |
|
| 2009 |
Keyari CM, Knapp BI, Bidlack JM, Lowey J, Bilsky EJ, Polt R. Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice. Advances in Experimental Medicine and Biology. 611: 495-6. PMID 19400281 DOI: 10.1007/978-0-387-73657-0_214 |
0.671 |
|
| 2009 |
Pelotte AL, Smith RM, Ayestas M, Dersch CM, Bilsky EJ, Rothman RB, Deveau AM. Design, synthesis, and characterization of 6beta-naltrexol analogs, and their selectivity for in vitro opioid receptor subtypes. Bioorganic & Medicinal Chemistry Letters. 19: 2811-4. PMID 19364645 DOI: 10.1016/j.bmcl.2009.03.095 |
0.583 |
|
| 2008 |
Do Carmo GP, Polt R, Bilsky EJ, Rice KC, Negus SS. Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 326: 939-48. PMID 18511649 DOI: 10.1124/Jpet.108.138180 |
0.523 |
|
| 2007 |
Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, et al. Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. Journal of Medicinal Chemistry. 50: 3765-76. PMID 17625813 DOI: 10.1021/Jm061325E |
0.349 |
|
| 2007 |
Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists. Organic & Biomolecular Chemistry. 5: 1177-90. PMID 17406716 DOI: 10.1039/B618875C |
0.545 |
|
| 2007 |
Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Glycosylation improves the central effects of DAMGO. Chemical Biology & Drug Design. 69: 41-7. PMID 17313456 DOI: 10.1111/J.1747-0285.2007.00462.X |
0.367 |
|
| 2005 |
Dogrul A, Bilsky EJ, Ossipov MH, Lai J, Porreca F. Spinal L-type calcium channel blockade abolishes opioid-induced sensory hypersensitivity and antinociceptive tolerance. Anesthesia and Analgesia. 101: 1730-5. PMID 16301251 DOI: 10.1213/01.ANE.0000184253.49849.B0 |
0.517 |
|
| 2005 |
Xu H, Wang X, Zimmerman D, Boja ES, Wang J, Bilsky EJ, Rothman RB. Chronic morphine up-regulates G alpha12 and cytoskeletal proteins in Chinese hamster ovary cells expressing the cloned mu opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. 315: 248-55. PMID 15987828 DOI: 10.1124/jpet.105.089367 |
0.545 |
|
| 2005 |
Raehal KM, Lowery JJ, Bhamidipati CM, Paolino RM, Blair JR, Wang D, Sadée W, Bilsky EJ. In vivo characterization of 6beta-naltrexol, an opioid ligand with less inverse agonist activity compared with naltrexone and naloxone in opioid-dependent mice. The Journal of Pharmacology and Experimental Therapeutics. 313: 1150-62. PMID 15716384 DOI: 10.1124/jpet.104.082966 |
0.724 |
|
| 2005 |
Sadée W, Wang D, Bilsky EJ. Basal opioid receptor activity, neutral antagonists, and therapeutic opportunities. Life Sciences. 76: 1427-37. PMID 15680308 DOI: 10.1016/j.lfs.2004.10.024 |
0.652 |
|
| 2004 |
Elmagbari NO, Egleton RD, Palian MM, Lowery JJ, Schmid WR, Davis P, Navratilova E, Dhanasekaran M, Keyari CM, Yamamura HI, Porreca F, Hruby VJ, Polt R, Bilsky EJ. Antinociceptive structure-activity studies with enkephalin-based opioid glycopeptides. The Journal of Pharmacology and Experimental Therapeutics. 311: 290-7. PMID 15166257 DOI: 10.1124/Jpet.104.069393 |
0.489 |
|
| 2004 |
Ananthan S, Khare NK, Saini SK, Seitz LE, Bartlett JL, Davis P, Dersch CM, Porreca F, Rothman RB, Bilsky EJ. Identification of opioid ligands possessing mixed micro agonist/delta antagonist activity among pyridomorphinans derived from naloxone, oxymorphone, and hydromorphone [correction of hydropmorphone]. Journal of Medicinal Chemistry. 47: 1400-12. PMID 14998329 DOI: 10.1021/jm030311v |
0.49 |
|
| 2004 |
Wang D, Raehal KM, Lin ET, Lowery JJ, Kieffer BL, Bilsky EJ, Sadée W. Basal signaling activity of mu opioid receptor in mouse brain: role in narcotic dependence. The Journal of Pharmacology and Experimental Therapeutics. 308: 512-20. PMID 14600246 DOI: 10.1124/Jpet.103.054049 |
0.715 |
|
| 2001 |
Wang D, Raehal KM, Bilsky EJ, Sadée W. Inverse agonists and neutral antagonists at mu opioid receptor (MOR): possible role of basal receptor signaling in narcotic dependence. Journal of Neurochemistry. 77: 1590-600. PMID 11413242 DOI: 10.1046/J.1471-4159.2001.00362.X |
0.718 |
|
| 2000 |
Brosnan-Watters G, Ogimi T, Ford D, Tatekawa L, Gilliam D, Bilsky EJ, Nash D. Differential effects of MK-801 on cerebrocortical neuronal injury in C57BL/6J, NSA, and ICR Mice Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 925-938. PMID 11041535 DOI: 10.1016/S0278-5846(00)00111-1 |
0.328 |
|
| 2000 |
Bilsky EJ, Egleton RD, Mitchell SA, Palian MM, Davis P, Huber JD, Jones H, Yamamura HI, Janders J, Davis TP, Porreca F, Hruby VJ, Polt R. Enkephalin glycopeptide analogues produce analgesia with reduced dependence liability. Journal of Medicinal Chemistry. 43: 2586-90. PMID 10891118 DOI: 10.1021/Jm000077Y |
0.453 |
|
| 1999 |
Wang Z, Bilsky EJ, Wang D, Porreca F, Sadée W. 3-Isobutyl-1-methylxanthine inhibits basal mu-opioid receptor phosphorylation and reverses acute morphine tolerance and dependence in mice. European Journal of Pharmacology. 371: 1-9. PMID 10355588 DOI: 10.1016/S0014-2999(99)00131-4 |
0.702 |
|
| 1998 |
Bilsky EJ, Montegut MJ, Nichols ML, Reid LD. CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences. Pharmacology, Biochemistry, and Behavior. 59: 215-20. PMID 9443558 DOI: 10.1016/S0091-3057(97)00424-3 |
0.324 |
|
| 1997 |
Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. Journal of Medicinal Chemistry. 40: 695-704. PMID 9057856 DOI: 10.1021/Jm960319N |
0.603 |
|
| 1996 |
Bilsky EJ, Inturrisi CE, Sadée W, Hruby VJ, Porreca F. Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective μ or δ opioid agonists in mice Pain. 68: 229-237. PMID 9121809 DOI: 10.1016/S0304-3959(96)03185-5 |
0.666 |
|
| 1996 |
Bilsky EJ, Wang T, Lai J, Porreca F. Selective blockade of peripheral delta opioid agonist induced antinociception by intrathecal administration of delta receptor antisense oligodeoxynucleotide. Neuroscience Letters. 220: 155-8. PMID 8994216 DOI: 10.1016/S0304-3940(96)13262-6 |
0.634 |
|
| 1996 |
Lai J, Riedl M, Stone LS, Arvidsson U, Bilsky EJ, Wilcox GL, Elde R, Porreca F. Immunofluorescence analysis of antisense oligodeoxynucleotide-mediated 'knock-down' of the mouse delta opioid receptor in vitro and in vivo. Neuroscience Letters. 213: 205-8. PMID 8873150 DOI: 10.1016/0304-3940(96)12883-4 |
0.535 |
|
| 1996 |
Zaki PA, Bilsky EJ, Vanderah TW, Lai J, Evans CJ, Porreca F. Opioid receptor types and subtypes: the delta receptor as a model. Annual Review of Pharmacology and Toxicology. 36: 379-401. PMID 8725395 DOI: 10.1146/Annurev.Pa.36.040196.002115 |
0.643 |
|
| 1995 |
Reid LD, Glick SD, Menkens KA, French ED, Bilsky EJ, Porreca F. Cocaine self-administration and naltrindole, a delta-selective opioid antagonist Neuroreport. 6: 1409-1412. PMID 7488736 DOI: 10.1097/00001756-199507100-00012 |
0.517 |
|
| 1994 |
Haaseth RC, Horan PJ, Bilsky EJ, Davis P, Zalewska T, Slaninova J, Yamamura HI, Weber SJ, Davis TP, Porreca F. [L-Ala3]DPDPE: a new enkephalin analog with a unique opioid receptor activity profile. Further evidence of delta-opioid receptor multiplicity. Journal of Medicinal Chemistry. 37: 1572-7. PMID 8201592 DOI: 10.1021/Jm00037A007 |
0.554 |
|
| 1994 |
Lai J, Bilsky EJ, Rothman RB, Porreca F. Treatment with antisense oligodeoxynucleotide to the opioid δ receptor selectively inhibits δ<inf>2</inf>-agonist antinociception Neuroreport. 5: 1049-1052. PMID 8080957 DOI: 10.1097/00001756-199405000-00008 |
0.605 |
|
| 1994 |
Polt R, Porreca F, Szabò LZ, Bilsky EJ, Davis P, Abbruscato TJ, Davis TP, Harvath R, Yamamura HI, Hruby VJ. Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. 91: 7114-8. PMID 8041755 DOI: 10.1073/Pnas.91.15.7114 |
0.498 |
|
| 1994 |
Bilsky EJ, Bernstein RN, Pasternak GW, Hruby VJ, Patel D, Porreca F, Lai J. Selective inhibition of [D-ALA2, GLU4]deltrophin antinociception by supraspinal, but not spinal, administration of an antisense oligodeoxynucleotide to an opioid delta receptor Life Sciences. 55: PL37-PL43. PMID 8015351 DOI: 10.1016/0024-3205(94)90110-4 |
0.528 |
|
| 1994 |
Lai J, Bilsky EJ, Bernstein RN, Rothman RB, Pasternak GW, Porreca F. Antisense oligodeoxynucleotide to the cloned delta opioid receptor selectively inhibits supraspinal, but not spinal, antinociceptive effects of [D-Ala2, Glu4]deltorphin Regulatory Peptides. 54: 159-160. DOI: 10.1016/0167-0115(94)90439-1 |
0.606 |
|
| 1994 |
Bilsky EJ, Bernstein RN, Davis P, Calderon SN, Rice KC, Rothman RB, Porreca F. Characterization of enantiomers of (±)BW373U86 and related compounds: Highly selective non-peptidic delta opioid agonists Regulatory Peptides. 54: 25-26. DOI: 10.1016/0167-0115(94)90371-9 |
0.5 |
|
| 1993 |
Reid LD, Hubbell CL, Glaccum MB, Bilsky EJ, Portoghese PS, Porreca F. Naltrindole, an opioid delta receptor antagonist, blocks cocaine-induced facilitation of responding for rewarding brain stimulation Life Sciences. 52: PL67-PL71. PMID 8382329 DOI: 10.1016/0024-3205(93)90084-G |
0.502 |
|
| 1992 |
Bilsky EJ, Montegut MJ, Delong CL, Reid LD. Opioidergic modulation of cocaine conditioned place preferences Life Sciences. 50. PMID 1552818 DOI: 10.1016/0024-3205(92)90105-X |
0.422 |
|
| 1992 |
Menkens K, Bilsky EJ, Wild KD, Portoghese PS, Reid LD, Porreca F. Cocaine place preference is blocked by the δ-opioid receptor antagonist, naltrindole European Journal of Pharmacology. 219: 345-346. PMID 1425962 DOI: 10.1016/0014-2999(92)90319-Y |
0.508 |
|
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