Antony Rosen - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Immunology, Microbiology Biology

107 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Crawford JD, Wang H, Trejo-Zambrano D, Cimbro R, Talbot CC, Thomas MA, Curran AM, Girgis AA, Schroeder JT, Fava A, Goldman DW, Petri M, Rosen A, Antiochos B, Darrah E. The XIST lncRNA is a sex-specific reservoir of TLR7 ligands in SLE. Jci Insight. PMID 37733447 DOI: 10.1172/jci.insight.169344  0.631
2021 Antiochos B, Paz M, Li J, Goldman DW, Petri M, Darrah E, Cashman K, Sanz I, Burns KH, Ardeljan D, Andrade F, Rosen A. Autoantibodies targeting LINE-1-encoded ORF1p are associated with systemic lupus erythematosus diagnosis but not disease activity. Clinical and Experimental Rheumatology. PMID 34665712  0.674
2020 Mecoli CA, Adler BL, Yang Q, Hummers LK, Rosen A, Casciola-Rosen L, Shah AA. Cancer in Systemic Sclerosis: Analysis of antibodies against components of the Th/To Complex. Arthritis & Rheumatology (Hoboken, N.J.). PMID 33241644 DOI: 10.1002/Art.41493  0.313
2020 Rosen A. Abstract IA11: Autoimmune rheumatic diseases and cancer: An example of natural cancer immunoediting? Cancer Immunology Research. 8. DOI: 10.1158/2326-6074.Tumimm19-Ia11  0.362
2019 Shah AA, Laiho M, Rosen A, Casciola-Rosen L. Scleroderma patients with antibodies against the large subunits of both RNA polymerases-I and -III are protected against cancer. Arthritis & Rheumatology (Hoboken, N.J.). PMID 30888702 DOI: 10.1002/Art.40893  0.364
2019 Casciola-Rosen L, Shah A, Rosen A. Abstract IA22: Autoimmune rheumatic diseases and cancer Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-Ia22  0.394
2019 Li J, Goules A, Goldman D, Rosen A, Casciola-Rosen L, Petri M. 4 Anti-retinoblastoma protein antibodies are negatively associated with lupus nephritis Lupus Science & Medicine. 6. DOI: 10.1136/Lupus-2019-Lsm.4  0.415
2018 Darrah E, Yu F, Cappelli LC, Rosen A, O'Dell JR, Mikuls TR. Association of baseline peptidylarginine deiminase 4 autoantibodies with favorable response to treatment escalation in rheumatoid arthritis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 30507066 DOI: 10.1002/Art.40791  0.698
2018 Antiochos B, Matyszewski M, Sohn J, Casciola-Rosen L, Rosen A. IFI16 filament formation in salivary epithelial cells shapes the anti-IFI16 immune response in Sjögren's syndrome. Jci Insight. 3. PMID 30232276 DOI: 10.1172/Jci.Insight.120179  0.416
2017 Shi J, Darrah E, Sims GP, Mustelin T, Sampson K, Konig MF, Bingham CO, Rosen A, Andrade F. Affinity maturation shapes the function of agonistic antibodies to peptidylarginine deiminase type 4 in rheumatoid arthritis. Annals of the Rheumatic Diseases. PMID 29070531 DOI: 10.1136/Annrheumdis-2017-211489  0.731
2017 Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L. Anti-RNPC3 Antibodies as a Marker of Cancer-Associated Scleroderma. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28217959 DOI: 10.1002/Art.40065  0.393
2017 Rosen A. SP0017 Shared mechanisms in cancer and autoimmunity Annals of the Rheumatic Diseases. 76: 5-5. DOI: 10.1136/Annrheumdis-2017-Eular.7165  0.414
2016 Konig MF, Abusleme L, Reinholdt J, Palmer RJ, Teles RP, Sampson K, Rosen A, Nigrovic PA, Sokolove J, Giles JT, Moutsopoulos NM, Andrade F. Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis. Science Translational Medicine. 8: 369ra176. PMID 27974664 DOI: 10.1126/Scitranslmed.Aaj1921  0.441
2016 Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJ. Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821747 DOI: 10.1073/Pnas.1615990113  0.407
2016 Navarro-Millán I, Darrah E, Westfall AO, Mikuls TR, Reynolds RJ, Danila MI, Curtis JR, Rosen A, Bridges SL. Association of anti-peptidyl arginine deiminase antibodies with radiographic severity of rheumatoid arthritis in African Americans. Arthritis Research & Therapy. 18: 241. PMID 27770831 DOI: 10.1186/S13075-016-1126-7  0.721
2016 Darrah E, Kim A, Zhang X, Boronina T, Cole RN, Fava A, Giles JT, Bingham Iii CO, Chalmers MJ, Griffin PR, Sadegh-Nasseri S, Rosen A. Proteolysis by Granzyme B Enhances Presentation of Autoantigenic Peptidylarginine Deiminase 4 Epitopes in Rheumatoid Arthritis. Journal of Proteome Research. PMID 27700100 DOI: 10.1021/Acs.Jproteome.6B00617  0.784
2016 Baer AN, Petri M, Sohn J, Rosen A, Casciola-Rosen L. Antibodies to interferon-inducible protein-16 in primary Sjögren's syndrome are associated with markers of more severe diseas. Arthritis Care & Research. PMID 27159877 DOI: 10.1002/Acr.22917  0.335
2016 McMahan ZH, Cottrell TR, Wigley FM, Antiochos B, Zambidis ET, Park TS, Halushka MK, Gutierrez-Alamillo L, Cimbro R, Rosen A, Casciola-Rosen L. Autoantigens targeted in scleroderma patients with vascular disease are enriched in endothelial lineage cells. Arthritis & Rheumatology (Hoboken, N.J.). PMID 27159521 DOI: 10.1002/Art.39743  0.327
2016 Fava A, Cimbro R, Wigley FM, Liu QR, Rosen A, Boin F. Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma. Arthritis Research & Therapy. 18: 99. PMID 27145754 DOI: 10.1186/S13075-016-0993-2  0.38
2016 Rosen A, Casciola-Rosen L. Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases. Annual Review of Immunology. PMID 26907212 DOI: 10.1146/Annurev-Immunol-032414-112205  0.388
2015 McMahan ZH, Shah AA, Vaidya D, Wigley FM, Rosen A, Casciola-Rosen L. Anti-IFI16 antibodies in scleroderma are associated with digital gangrene. Arthritis & Rheumatology (Hoboken, N.J.). PMID 26714268 DOI: 10.1002/Art.39558  0.389
2015 Fiorentino DF, Presby M, Baer AN, Petri M, Rieger KE, Soloski M, Rosen A, Mammen AL, Christopher-Stine L, Casciola-Rosen L. PUF60: a prominent new target of the autoimmune response in dermatomyositis and Sjögren's syndrome. Annals of the Rheumatic Diseases. PMID 26253095 DOI: 10.1136/Annrheumdis-2015-207509  0.387
2015 Baer AN, Petri M, Sohn J, Rosen A, Casciola-Rosen L. Antibodies to interferon-inducible protein-16 in primary Sjögren's syndrome are associated with markers of more severe disease. Arthritis Care & Research. PMID 26037655 DOI: 10.1002/Acr.22632  0.399
2015 Hall JC, Baer AN, Shah AA, Criswell LA, Shiboski CH, Rosen A, Casciola-Rosen L. Molecular subsetting of interferon pathways in Sjogren's syndrome. Arthritis & Rheumatology (Hoboken, N.J.). PMID 25988820 DOI: 10.1002/Art.39204  0.372
2015 Shah AA, Hummers LK, Casciola-Rosen L, Visvanathan K, Rosen A, Wigley FM. Examination of autoantibody status and clinical features associated with cancer risk and cancer-associated scleroderma. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1053-61. PMID 25605296 DOI: 10.1002/Art.39022  0.308
2015 Shah AA, Casciola-Rosen L, Rosen A. Review: cancer-induced autoimmunity in the rheumatic diseases. Arthritis & Rheumatology (Hoboken, N.J.). 67: 317-26. PMID 25371098 DOI: 10.1002/Art.38928  0.369
2014 Duan-Porter WD, Woods VL, Maurer KD, Li S, Rosen A. Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B. Plos One. 9: e115062. PMID 25490769 DOI: 10.1371/Journal.Pone.0115062  0.693
2014 Giles JT, Darrah E, Danoff S, Johnson C, Andrade F, Rosen A, Bathon JM. Association of cross-reactive antibodies targeting peptidyl-arginine deiminase 3 and 4 with rheumatoid arthritis-associated interstitial lung disease. Plos One. 9: e98794. PMID 24901704 DOI: 10.1371/Journal.Pone.0098794  0.725
2014 Joseph CG, Darrah E, Shah AA, Skora AD, Casciola-Rosen LA, Wigley FM, Boin F, Fava A, Thoburn C, Kinde I, Jiao Y, Papadopoulos N, Kinzler KW, Vogelstein B, Rosen A. Association of the autoimmune disease scleroderma with an immunologic response to cancer. Science (New York, N.Y.). 343: 152-7. PMID 24310608 DOI: 10.1126/Science.1246886  0.715
2013 Romero V, Fert-Bober J, Nigrovic PA, Darrah E, Haque UJ, Lee DM, van Eyk J, Rosen A, Andrade F. Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis. Science Translational Medicine. 5: 209ra150. PMID 24174326 DOI: 10.1126/Scitranslmed.3006869  0.704
2013 Fiorentino DF, Chung LS, Christopher-Stine L, Zaba L, Li S, Mammen AL, Rosen A, Casciola-Rosen L. Most patients with cancer-associated dermatomyositis have antibodies to nuclear matrix protein NXP-2 or transcription intermediary factor 1γ. Arthritis and Rheumatism. 65: 2954-62. PMID 24037894 DOI: 10.1002/Art.38093  0.411
2013 Ferucci ED, Darrah E, Smolik I, Choromanski TL, Robinson DB, Newkirk MM, Fritzler MJ, Rosen A, El-Gabalawy HS. Prevalence of anti-peptidylarginine deiminase type 4 antibodies in rheumatoid arthritis and unaffected first-degree relatives in indigenous North American Populations. The Journal of Rheumatology. 40: 1523-8. PMID 23908443 DOI: 10.3899/Jrheum.130293  0.698
2013 Darrah E, Giles JT, Ols ML, Bull HG, Andrade F, Rosen A. Erosive rheumatoid arthritis is associated with antibodies that activate PAD4 by increasing calcium sensitivity. Science Translational Medicine. 5: 186ra65. PMID 23698378 DOI: 10.1126/Scitranslmed.3005370  0.707
2013 Mammen JS, Ghazarian SR, Rosen A, Ladenson PW. Patterns of interferon-alpha-induced thyroid dysfunction vary with ethnicity, sex, smoking status, and pretreatment thyrotropin in an international cohort of patients treated for hepatitis C. Thyroid : Official Journal of the American Thyroid Association. 23: 1151-8. PMID 23517287 DOI: 10.1089/Thy.2012.0565  0.32
2012 Hall JC, Casciola-Rosen L, Berger AE, Kapsogeorgou EK, Cheadle C, Tzioufas AG, Baer AN, Rosen A. Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases. Proceedings of the National Academy of Sciences of the United States of America. 109: 17609-14. PMID 23045702 DOI: 10.1073/Pnas.1209724109  0.36
2012 Cottrell TR, Hall JC, Rosen A, Casciola-Rosen L. Identification of novel autoantigens by a triangulation approach. Journal of Immunological Methods. 385: 35-44. PMID 22910000 DOI: 10.1016/J.Jim.2012.07.024  0.381
2012 Park JK, Askin F, Giles JT, Halushka MK, Rosen A, Levine SM. Increased generation of TRAP expressing multinucleated giant cells in patients with granulomatosis with polyangiitis. Plos One. 7: e42659. PMID 22905158 DOI: 10.1371/Journal.Pone.0042659  0.326
2012 Chaisson NF, Paik J, Orbai AM, Casciola-Rosen L, Fiorentino D, Danoff S, Rosen A. A novel dermato-pulmonary syndrome associated with MDA-5 antibodies: report of 2 cases and review of the literature. Medicine. 91: 220-8. PMID 22732950 DOI: 10.1097/Md.0B013E3182606F0B  0.349
2012 Giles JT, Fert-Bober J, Park JK, Bingham CO, Andrade F, Fox-Talbot K, Pappas D, Rosen A, van Eyk J, Bathon JM, Halushka MK. Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study. Arthritis Research & Therapy. 14: R39. PMID 22364592 DOI: 10.1186/Ar3752  0.368
2012 Darrah E, Rosen A, Giles JT, Andrade F. Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis. Annals of the Rheumatic Diseases. 71: 92-8. PMID 21859690 DOI: 10.1136/Ard.2011.151712  0.684
2012 Rosen A, Casciola-Rosen L. Abstract CN01-03: Autoimmune rheumatic diseases and cancer: Not just chance? Cancer Prevention Research. 5. DOI: 10.1158/1940-6207.Prev-12-Cn01-03  0.379
2011 Grader-Beck T, Boin F, von Gunten S, Smith D, Rosen A, Bochner BS. Antibodies recognising sulfated carbohydrates are prevalent in systemic sclerosis and associated with pulmonary vascular disease. Annals of the Rheumatic Diseases. 70: 2218-24. PMID 21873333 DOI: 10.1136/Ard.2011.153130  0.425
2011 Fiorentino D, Chung L, Zwerner J, Rosen A, Casciola-Rosen L. The mucocutaneous and systemic phenotype of dermatomyositis patients with antibodies to MDA5 (CADM-140): a retrospective study. Journal of the American Academy of Dermatology. 65: 25-34. PMID 21531040 DOI: 10.1016/J.Jaad.2010.09.016  0.445
2011 Sule S, Rosen A, Petri M, Akhter E, Andrade F. Abnormal production of pro- and anti-inflammatory cytokines by lupus monocytes in response to apoptotic cells. Plos One. 6: e17495. PMID 21423726 DOI: 10.1371/Journal.Pone.0017495  0.33
2011 Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Doering KR, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis and Rheumatism. 63: 713-21. PMID 21360500 DOI: 10.1002/Art.30156  0.717
2010 Shah AA, Rosen A, Hummers L, Wigley F, Casciola-Rosen L. Close temporal relationship between onset of cancer and scleroderma in patients with RNA polymerase I/III antibodies. Arthritis and Rheumatism. 62: 2787-95. PMID 20506513 DOI: 10.1002/Art.27549  0.356
2010 Kolfenbach JR, Deane KD, Derber LA, O'Donnell CI, Gilliland WR, Edison JD, Rosen A, Darrah E, Norris JM, Holers VM. Autoimmunity to peptidyl arginine deiminase type 4 precedes clinical onset of rheumatoid arthritis. Arthritis and Rheumatism. 62: 2633-9. PMID 20496417 DOI: 10.1002/Art.27570  0.7
2010 Golding A, Rosen A, Petri M, Akhter E, Andrade F. Interferon-alpha regulates the dynamic balance between human activated regulatory and effector T cells: implications for antiviral and autoimmune responses. Immunology. 131: 107-17. PMID 20465564 DOI: 10.1111/J.1365-2567.2010.03280.X  0.305
2010 Andrade F, Darrah E, Gucek M, Cole RN, Rosen A, Zhu X. Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation. Arthritis and Rheumatism. 62: 1630-40. PMID 20201080 DOI: 10.1002/Art.27439  0.642
2010 Niland B, Miklossy G, Banki K, Biddison WE, Casciola-Rosen L, Rosen A, Martinvalet D, Lieberman J, Perl A. Cleavage of transaldolase by granzyme B causes the loss of enzymatic activity with retention of antigenicity for multiple sclerosis patients. Journal of Immunology (Baltimore, Md. : 1950). 184: 4025-32. PMID 20194725 DOI: 10.4049/Jimmunol.0804174  0.36
2010 Darrah E, Rosen A. Granzyme B cleavage of autoantigens in autoimmunity. Cell Death and Differentiation. 17: 624-32. PMID 20075942 DOI: 10.1038/Cdd.2009.197  0.718
2010 Hall JC, Rosen A. Type I interferons: crucial participants in disease amplification in autoimmunity. Nature Reviews. Rheumatology. 6: 40-9. PMID 20046205 DOI: 10.1038/Nrrheum.2009.237  0.348
2010 Rosen A, Diamond JS. Arthritis & rheumatism Arthritis and Rheumatism. 62: 1563. DOI: 10.1002/Art.27480  0.356
2009 Boin F, Franchini S, Colantuoni E, Rosen A, Wigley FM, Casciola-Rosen L. Independent association of anti-beta(2)-glycoprotein I antibodies with macrovascular disease and mortality in scleroderma patients. Arthritis and Rheumatism. 60: 2480-9. PMID 19644882 DOI: 10.1002/Art.24684  0.403
2009 Suber T, Rosen A. Apoptotic cell blebs: repositories of autoantigens and contributors to immune context. Arthritis and Rheumatism. 60: 2216-9. PMID 19644864 DOI: 10.1002/Art.24715  0.755
2008 Casciola-Rosen L, Miagkov A, Nagaraju K, Askin F, Jacobson L, Rosen A, Drachman DB. Granzyme B: evidence for a role in the origin of myasthenia gravis. Journal of Neuroimmunology. 201: 33-40. PMID 18675462 DOI: 10.1016/J.Jneuroim.2008.04.041  0.454
2008 Harris ML, Darrah E, Lam GK, Bartlett SJ, Giles JT, Grant AV, Gao P, Scott WW, El-Gabalawy H, Casciola-Rosen L, Barnes KC, Bathon JM, Rosen A. Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritis. Arthritis and Rheumatism. 58: 1958-67. PMID 18576335 DOI: 10.1002/Art.23596  0.78
2008 Suber TL, Casciola-Rosen L, Rosen A. Mechanisms of disease: autoantigens as clues to the pathogenesis of myositis. Nature Clinical Practice. Rheumatology. 4: 201-9. PMID 18319710 DOI: 10.1038/Ncprheum0760  0.771
2007 Levine SM, Raben N, Xie D, Askin FB, Tuder R, Mullins M, Rosen A, Casciola-Rosen LA. Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis. Arthritis and Rheumatism. 56: 2729-39. PMID 17665459 DOI: 10.1002/Art.22790  0.373
2007 Grader-Beck T, Casciola-Rosen L, Lang TJ, Puliaev R, Rosen A, Via CS. Apoptotic splenocytes drive the autoimmune response to poly(ADP-ribose) polymerase 1 in a murine model of lupus. Journal of Immunology (Baltimore, Md. : 1950). 178: 95-102. PMID 17182544 DOI: 10.4049/Jimmunol.178.1.95  0.393
2007 Casciola-Rosen L, Garcia-Calvo M, Bull HG, Becker JW, Hines T, Thornberry NA, Rosen A. Mouse and human granzyme B have distinct tetrapeptide specificities and abilities to recruit the bid pathway. The Journal of Biological Chemistry. 282: 4545-52. PMID 17179148 DOI: 10.1074/Jbc.M606564200  0.336
2006 Rosen A, Casciola-Rosen L. Stem cells in inflammatory disease. Current Opinion in Rheumatology. 18: 618-9. PMID 17053508 DOI: 10.1097/01.Bor.0000245723.87264.D8  0.305
2006 Gelber AC, Pillemer SR, Baum BJ, Wigley FM, Hummers LK, Morris S, Rosen A, Casciola-Rosen LA. Distinct recognition of antibodies to centromere proteins in primary Sjögren’s syndrome compared with limited scleroderma Annals of the Rheumatic Diseases. 65: 1028-1032. PMID 16414973 DOI: 10.1136/Ard.2005.046003  0.386
2006 Jo Mulligan-Kehoe M, Drinane MC, Casciola-Rosen L, Hummers LK, Hall AE, Rosen A, Wigley FM, Simons M. Granzyme B-dependent matrix degradation generates anti-angiostatic activity in scleroderma patients Vascular Pharmacology. 45: e147. DOI: 10.1016/J.Vph.2006.08.384  0.343
2005 Boin F, Wigley FM, Schneck JP, Oelke M, Rosen A. Evaluation of topoisomerase-1-specific CD8+ T-cell response in systemic sclerosis. Annals of the New York Academy of Sciences. 1062: 137-45. PMID 16461796 DOI: 10.1196/Annals.1358.016  0.375
2005 Duan-Porter WD, Casciola-Rosen L, Rosen A. Autoantigens: the critical partner in initiating and propagating systemic autoimmunity. Annals of the New York Academy of Sciences. 1062: 127-36. PMID 16461795 DOI: 10.1196/Annals.1358.015  0.734
2005 Mahoney JA, Rosen A. Apoptosis and autoimmunity. Current Opinion in Immunology. 17: 583-8. PMID 16214321 DOI: 10.1016/J.Coi.2005.09.018  0.408
2005 Nagaraju K, Casciola-Rosen L, Lundberg I, Rawat R, Cutting S, Thapliyal R, Chang J, Dwivedi S, Mitsak M, Chen YW, Plotz P, Rosen A, Hoffman E, Raben N. Activation of the endoplasmic reticulum stress response in autoimmune myositis: potential role in muscle fiber damage and dysfunction. Arthritis and Rheumatism. 52: 1824-35. PMID 15934115 DOI: 10.1002/Art.21103  0.37
2005 Andrade F, Casciola-Rosen LA, Rosen A. Generation of novel covalent RNA-protein complexes in cells by ultraviolet B irradiation: implications for autoimmunity. Arthritis and Rheumatism. 52: 1160-70. PMID 15818701 DOI: 10.1002/Art.20992  0.346
2005 Casciola-Rosen L, Nagaraju K, Plotz P, Wang K, Levine S, Gabrielson E, Corse A, Rosen A. Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy. The Journal of Experimental Medicine. 201: 591-601. PMID 15728237 DOI: 10.1084/Jem.20041367  0.394
2004 Spinette S, Lengauer C, Mahoney JA, Jallepalli PV, Wang Z, Casciola-Rosen L, Rosen A. Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation. Cell Cycle (Georgetown, Tex.). 3: 1638-44. PMID 15611659 DOI: 10.4161/Cc.3.12.1345  0.329
2004 Roberts KM, Rosen A, Casciola-Rosen LA. Methods for inducing apoptosis. Methods in Molecular Medicine. 102: 115-28. PMID 15286383 DOI: 10.1385/1-59259-805-6:115  0.342
2004 Hall JC, Casciola-Rosen L, Rosen A. Altered structure of autoantigens during apoptosis. Rheumatic Diseases Clinics of North America. 30: 455-71, vii. PMID 15261336 DOI: 10.1016/J.Rdc.2004.04.012  0.34
2004 Ulanet DB, Flavahan NA, Casciola-Rosen L, Rosen A. Selective cleavage of nucleolar autoantigen B23 by granzyme B in differentiated vascular smooth muscle cells: insights into the association of specific autoantibodies with distinct disease phenotypes. Arthritis and Rheumatism. 50: 233-41. PMID 14730621 DOI: 10.1002/Art.11485  0.777
2004 Hummers LK, Krishnan C, Casciola-Rosen L, Rosen A, Morris S, Mahoney JA, Kerr DA, Wigley FM. Recurrent transverse myelitis associates with anti-Ro (SSA) autoantibodies. Neurology. 62: 147-9. PMID 14718721 DOI: 10.1212/01.Wnl.0000101715.32569.1A  0.336
2004 Andrade F, Casciola-Rosen LA, Rosen A. Granzyme B-induced cell death. Acta Haematologica. 111: 28-41. PMID 14646343 DOI: 10.1159/000074484  0.347
2003 Harris ML, Rosen A. Autoimmunity in scleroderma: the origin, pathogenetic role, and clinical significance of autoantibodies. Current Opinion in Rheumatology. 15: 778-84. PMID 14569210 DOI: 10.1097/00002281-200311000-00016  0.583
2003 Levine SM, Rosen A, Casciola-Rosen LA. Anti-aminoacyl tRNA synthetase immune responses: insights into the pathogenesis of the idiopathic inflammatory myopathies. Current Opinion in Rheumatology. 15: 708-13. PMID 14569199 DOI: 10.1097/00002281-200311000-00005  0.412
2003 Ulanet DB, Torbenson M, Dang CV, Casciola-Rosen L, Rosen A. Unique conformation of cancer autoantigen B23 in hepatoma: a mechanism for specificity in the autoimmune response. Proceedings of the National Academy of Sciences of the United States of America. 100: 12361-6. PMID 14519847 DOI: 10.1073/Pnas.2035245100  0.785
2003 White S, Rosen A. Apoptosis in systemic lupus erythematosus. Current Opinion in Rheumatology. 15: 557-62. PMID 12960480 DOI: 10.1097/00002281-200309000-00006  0.436
2003 Andrade F, Casciola-Rosen LA, Rosen A. A novel domain in adenovirus L4-100K is required for stable binding and efficient inhibition of human granzyme B: possible interaction with a species-specific exosite. Molecular and Cellular Biology. 23: 6315-26. PMID 12917351 DOI: 10.1128/Mcb.23.17.6315-6326.2003  0.33
2003 Ulanet DB, Wigley FM, Gelber AC, Rosen A. Autoantibodies against B23, a nucleolar phosphoprotein, occur in scleroderma and are associated with pulmonary hypertension. Arthritis and Rheumatism. 49: 85-92. PMID 12579598 DOI: 10.1002/Art.10914  0.77
2002 Howard OM, Dong HF, Yang D, Raben N, Nagaraju K, Rosen A, Casciola-Rosen L, Härtlein M, Kron M, Yang D, Yiadom K, Dwivedi S, Plotz PH, Oppenheim JJ. Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells. The Journal of Experimental Medicine. 196: 781-91. PMID 12235211 DOI: 10.1084/Jem.20020186  0.36
2002 Schachna L, Wigley FM, Morris S, Gelber AC, Rosen A, Casciola-Rosen L. Recognition of Granzyme B-generated autoantigen fragments in scleroderma patients with ischemic digital loss. Arthritis and Rheumatism. 46: 1873-84. PMID 12124872 DOI: 10.1002/Art.10407  0.434
2002 Mahoney JA, Odin JA, White SM, Shaffer D, Koff A, Casciola-Rosen L, Rosen A. The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis. The Biochemical Journal. 361: 587-95. PMID 11802788 DOI: 10.1042/Bj3610587  0.308
2001 Odin JA, Huebert RC, Casciola-Rosen L, LaRusso NF, Rosen A. Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis Journal of Clinical Investigation. 108: 223-232. PMID 11457875 DOI: 10.1172/Jci10716  0.301
2001 Andrade F, Bull HG, Thornberry NA, Ketner GW, Casciola-Rosen LA, Rosen A. Adenovirus L4-100K assembly protein is a Granzyme B substrate that potently inhibits Granzyme B-mediated cell death Immunity. 14: 751-761. PMID 11420045 DOI: 10.1016/S1074-7613(01)00149-2  0.304
2001 Rosen A, Casciola-Rosen L. Clearing the way to mechanisms of autoimmunity. Nature Medicine. 7: 664-5. PMID 11385500 DOI: 10.1038/89034  0.327
2001 Casciola-Rosen LA, Pluta AF, Plotz PH, Cox AE, Morris S, Wigley FM, Petri M, Gelber AC, Rosen A. The DNA mismatch repair enzyme PMS1 is a myositis-specific autoantigen Arthritis and Rheumatism. 44: 389-396. PMID 11229471 DOI: 10.1002/1529-0131(200102)44:2<389::Aid-Anr58>3.0.Co;2-R  0.436
2000 Goldbach-Mansky R, Lee J, McCoy A, Hoxworth J, Yarboro C, Smolen JS, Steiner G, Rosen A, Zhang C, Ménard HA, Zhou ZJ, Palosuo T, Van Venrooij WJ, Wilder RL, Klippel JH, et al. Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset. Arthritis Research. 2: 236-43. PMID 11056669 DOI: 10.1186/Ar93  0.454
2000 Nagaraju K, Casciola-Rosen L, Rosen A, Thompson C, Loeffler L, Parker T, Danning C, Rochon PJ, Gillespie J, Plotz P. The inhibition of apoptosis in myositis and in normal muscle cells. Journal of Immunology. 164: 5459-5465. PMID 10799913 DOI: 10.4049/Jimmunol.164.10.5459  0.339
2000 Andrade F, Casciola-Rosen L, Rosen A. Apoptosis in systemic lupus erythematosus. Clinical implications. Rheumatic Diseases Clinics of North America. 26: 215-27, v. PMID 10768210 DOI: 10.1016/S0889-857X(05)70136-8  0.383
2000 Greidinger EL, Casciola-Rosen L, Morris SM, Hoffman RW, Rosen A. Autoantibody recognition of distinctly modified forms of the U1-70-kd antigen is associated with different clinical disease manifestations. Arthritis and Rheumatism. 43: 881-8. PMID 10765934 DOI: 10.1002/1529-0131(200004)43:4<881::Aid-Anr20>3.0.Co;2-G  0.392
2000 Dillon SR, Mancini M, Rosen A, Schlissel MS. Annexin V binds to viable B cells and colocalizes with a marker of lipid rafts upon B cell receptor activation. Journal of Immunology (Baltimore, Md. : 1950). 164: 1322-32. PMID 10640746 DOI: 10.4049/Jimmunol.164.3.1322  0.339
1999 Casciola-Rosen L, Andrade F, Ulanet D, Wong WB, Rosen A. Cleavage by granzyme B is strongly predictive of autoantigen status: implications for initiation of autoimmunity. The Journal of Experimental Medicine. 190: 815-26. PMID 10499920 DOI: 10.1084/Jem.190.6.815  0.772
1999 Rosen A, Casciola-Rosen L. Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death and Differentiation. 6: 6-12. PMID 10200542 DOI: 10.1038/Sj.Cdd.4400460  0.423
1998 Greidinger EL, Flaherty KT, White B, Rosen A, Wigley FM, Wise RA. African-American race and antibodies to topoisomerase I are associated with increased severity of scleroderma lung disease Chest. 114: 801-807. PMID 9743170 DOI: 10.1378/Chest.114.3.801  0.359
1998 Andrade F, Roy S, Nicholson D, Thornberry N, Rosen A, Casciola-Rosen L. Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis. Immunity. 8: 451-60. PMID 9586635 DOI: 10.1016/S1074-7613(00)80550-6  0.314
1998 Sanghavi DM, Thelen M, Thornberry NA, Casciola-Rosen L, Rosen A. Caspase-mediated proteolysis during apoptosis: insights from apoptotic neutrophils. Febs Letters. 422: 179-84. PMID 9490001 DOI: 10.1016/S0014-5793(98)00004-0  0.322
1997 Rosen A, Casciola-rosen L, Wigley F. Role of metal-catalyzed oxidation reactions in the early pathogenesis of scleroderma. Current Opinion in Rheumatology. 9: 538-543. PMID 9375283 DOI: 10.1097/00002281-199711000-00010  0.303
1997 Casciola-Rosen L, Rosen A. Ultraviolet light-induced keratinocyte apoptosis: a potential mechanism for the induction of skin lesions and autoantibody production in LE. Lupus. 6: 175-80. PMID 9061666 DOI: 10.1177/096120339700600213  0.408
1997 Rosen A, Casciola-Rosen L. Macromolecular substrates for the ICE-like proteases during apoptosis Journal of Cellular Biochemistry. 64: 50-54. PMID 9015754 DOI: 10.1002/(Sici)1097-4644(199701)64:1<50::Aid-Jcb8>3.0.Co;2-Z  0.327
1997 Casciola-Rosen L, Wigley F, Rosen A. Scleroderma Autoantigens Are Uniquely Fragmented by Metal-catalyzed Oxidation Reactions: Implications for Pathogenesis Journal of Experimental Medicine. 185: 71-79. PMID 8996243 DOI: 10.1084/Jem.185.1.71  0.312
1996 Casciola-Rosen L, Rosen A, Petri M, Schlissel M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proceedings of the National Academy of Sciences of the United States of America. 93: 1624-9. PMID 8643681 DOI: 10.1073/Pnas.93.4.1624  0.409
1995 Rosen A, Casciola-Rosen L, Ahearn J. Novel packages of viral and self-antigens are generated during apoptosis. Journal of Experimental Medicine. 181: 1557-1561. PMID 7699336 DOI: 10.1084/Jem.181.4.1557  0.325
1995 Casciola-Rosen LA, Anhalt GJ, Rosen A. DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. Journal of Experimental Medicine. 182: 1625-1634. PMID 7500007 DOI: 10.1084/Jem.182.6.1625  0.332
1994 Casciola-Rosen LA, Anhalt G, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. Journal of Experimental Medicine. 179: 1317-1330. PMID 7511686 DOI: 10.1084/Jem.179.4.1317  0.314
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