Bart De Strooper - Publications

Affiliations: 
Laboratory of Neuronal Cell Biology and Gene Transfer  Katholieke Universiteit Leuven, Leuven, Vlaanderen, Belgium 
Website:
http://med.kuleuven.be/cme-mg/lncb/index.html

272 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B. PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proceedings of the National Academy of Sciences of the United States of America. 116: 277-286. PMID 30578322 DOI: 10.1073/pnas.1811938116  0.6
2018 Voytyuk I, Mueller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B. BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance. 1: e201800026. PMID 30456346 DOI: 10.26508/lsa.201800026  0.76
2017 Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG. Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. Plos One. 12: e0178016. PMID 28686613 DOI: 10.1371/journal.pone.0178016  0.32
2017 Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B. Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. Embo Molecular Medicine. PMID 28588032 DOI: 10.15252/emmm.201707561  0.6
2017 Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, Vandersarren L, Janssens S, Ramou I, Savvides SN, Haigh JJ, Hendriks R, Kopf M, Craessaerts K, de Strooper B, et al. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Nature Immunology. PMID 28068307 DOI: 10.1038/ni.3657  0.44
2016 Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, ... ... De Strooper B, et al. Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell. PMID 27293189 DOI: 10.1016/j.cell.2016.05.020  0.32
2016 Barão S, Moechars D, Lichtenthaler SF, De Strooper B. BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease. Trends in Neurosciences. PMID 26833257 DOI: 10.1016/j.tins.2016.01.003  0.76
2016 Aerts L, Craessaerts K, De Strooper B, Morais VA. In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues. Plos One. 11: e0146083. PMID 26784449 DOI: 10.1371/journal.pone.0146083  0.44
2016 Dooley J, Garcia-Perez JE, Sreenivasan J, Schlenner SM, Vangoitsenhoven R, Papadopoulou AS, Tian L, Schonefeldt S, Serneels L, Deroose C, Staats KA, Van der Schueren B, De Strooper B, McGuinness OP, Mathieu C, et al. The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity. Diabetes. 65: 53-61. PMID 26696639 DOI: 10.2337/db15-0770  1
2015 Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, ... ... De Strooper B, et al. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine. 7: 309ra164. PMID 26468326 DOI: 10.1126/scitranslmed.aab3492  1
2015 Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, et al. Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease. Neurobiology of Aging. PMID 26410308 DOI: 10.1016/j.neurobiolaging.2015.08.026  1
2015 Brkic M, Balusu S, Van Wonterghem E, Gorlé N, Benilova I, Kremer A, Van Hove I, Moons L, De Strooper B, Kanazir S, Libert C, Vandenbroucke RE. Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12766-78. PMID 26377465 DOI: 10.1523/JNEUROSCI.0006-15.2015  1
2015 Barão S, Gärtner A, Leyva-Díaz E, Demyanenko G, Munck S, Vanhoutvin T, Zhou L, Schachner M, López-Bendito G, Maness PF, De Strooper B. Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse. Cell Reports. 12: 1367-76. PMID 26299962 DOI: 10.1016/j.celrep.2015.07.059  1
2015 Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, et al. Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome. Neuron. 87: 382-98. PMID 26182420 DOI: 10.1016/j.neuron.2015.06.032  1
2015 Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Reports. 11: 1176-83. PMID 25981034 DOI: 10.1016/j.celrep.2015.04.043  1
2015 Sala Frigerio C, Lau P, Troakes C, Deramecourt V, Gele P, Van Loo P, Voet T, De Strooper B. On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25937274 DOI: 10.1016/j.jalz.2015.02.007  1
2015 Aerts L, De Strooper B, Morais VA. PINK1 activation-turning on a promiscuous kinase. Biochemical Society Transactions. 43: 280-6. PMID 25849930 DOI: 10.1042/BST20150002  1
2015 Hu W, Dooley J, Chung SS, Chandramohan D, Cimmino L, Mukherjee S, Mason CE, de Strooper B, Liston A, Park CY. miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a. Blood. 125: 2206-16. PMID 25634742 DOI: 10.1182/blood-2014-06-585273  1
2015 Aerts L, Craessaerts K, De Strooper B, Morais VA. PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. The Journal of Biological Chemistry. 290: 2798-811. PMID 25527497 DOI: 10.1074/jbc.M114.620906  1
2015 Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L. The dynamic conformational landscape of gamma-secretase Nadav. Journal of Cell Science. 128: 589-98. PMID 25501811 DOI: 10.1242/jcs.164384  1
2015 Arranz AM, Delbroek L, Van Kolen K, Guimarães MR, Mandemakers W, Daneels G, Matta S, Calafate S, Shaban H, Baatsen P, De Bock PJ, Gevaert K, Berghe PV, Verstreken P, De Strooper B, et al. LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism. Journal of Cell Science. 128: 541–52. PMID 25501810 DOI: 10.1242/jcs.158196  0.76
2015 De Strooper B, Chávez Gutiérrez L. Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond. Annual Review of Pharmacology and Toxicology. 55: 419-37. PMID 25292430 DOI: 10.1146/annurev-pharmtox-010814-124309  1
2015 O'Flanagan CH, Morais VA, Wurst W, De Strooper B, O'Neill C. The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes. Oncogene. 34: 1363-74. PMID 24681957 DOI: 10.1038/onc.2014.81  1
2015 Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, et al. Errata to Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to SynapticDeficits in Fragile X Syndrome [Neuron, 87, (2015), 382-398] Neuron. 87: 908. DOI: 10.1016/j.neuron.2015.08.010  1
2014 De Strooper B. Lessons from a failed γ-secretase Alzheimer trial. Cell. 159: 721-6. PMID 25417150 DOI: 10.1016/j.cell.2014.10.016  1
2014 Papadopoulou AS, Serneels L, Achsel T, Mandemakers W, Callaerts-Vegh Z, Dooley J, Lau P, Ayoubi T, Radaelli E, Spinazzi M, Neumann M, Hébert SS, Silahtaroglu A, Liston A, D'Hooge R, ... ... De Strooper B, et al. Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice. Neurobiology of Disease. 73: 275-288. PMID 25315682 DOI: 10.1016/j.nbd.2014.10.006  1
2014 Benilova I, Gallardo R, Ungureanu AA, Castillo Cano V, Snellinx A, Ramakers M, Bartic C, Rousseau F, Schymkowitz J, De Strooper B. The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation. The Journal of Biological Chemistry. 289: 30977-89. PMID 25253695 DOI: 10.1074/jbc.M114.599027  1
2014 Salta E, Lau P, Sala Frigerio C, Coolen M, Bally-Cuif L, De Strooper B. A self-organizing miR-132/Ctbp2 circuit regulates bimodal notch signals and glial progenitor fate choice during spinal cord maturation. Developmental Cell. 30: 423-36. PMID 25132384 DOI: 10.1016/j.devcel.2014.07.006  1
2014 De Kloe GE, De Strooper B. Small molecules that inhibit Notch signaling. Methods in Molecular Biology (Clifton, N.J.). 1187: 311-22. PMID 25053499 DOI: 10.1007/978-1-4939-1139-4_23  1
2014 Serneels L, Tesseur I, De Strooper B. Assay to probe proteolytic processing of Notch by γ-secretase. Methods in Molecular Biology (Clifton, N.J.). 1187: 223-9. PMID 25053493 DOI: 10.1007/978-1-4939-1139-4_17  1
2014 Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A, Shariati SA, Balschun D, De Strooper B. Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling. Elife. 3. PMID 24891237 DOI: 10.7554/eLife.02196  0.6
2014 Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W. The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Human Molecular Genetics. 23: 5227-42. PMID 24852371 DOI: 10.1093/hmg/ddu244  1
2014 Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science (New York, N.Y.). 344: 203-7. PMID 24652937 DOI: 10.1126/science.1249161  1
2014 Lau P, Frigerio CS, De Strooper B. Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing Research Reviews. 17: 43-53. PMID 24607832 DOI: 10.1016/j.arr.2014.02.006  1
2014 Pimenova AA, Thathiah A, De Strooper B, Tesseur I. Regulation of amyloid precursor protein processing by serotonin signaling. Plos One. 9: e87014. PMID 24466315 DOI: 10.1371/journal.pone.0087014  1
2014 Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, Hébert SS. Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. Plos One. 9: e85510. PMID 24427314 DOI: 10.1371/journal.pone.0085510  1
2014 Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B. Signature amyloid β profiles are produced by different γ-secretase complexes. The Journal of Biological Chemistry. 289: 4346-55. PMID 24338474 DOI: 10.1074/jbc.M113.530907  1
2014 Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch KP, Fitzsimons CP, De Strooper B, Rutten BP. Epigenetically regulated microRNAs in Alzheimer's disease. Neurobiology of Aging. 35: 731-45. PMID 24238656 DOI: 10.1016/j.neurobiolaging.2013.10.082  1
2014 Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A, Shariati SAM, Balschun D, De Strooper B. Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling Elife. 2014. DOI: 10.7554/eLife.02196.001  1
2014 Finoulst M, Vankrunkelsven P, De Strooper B, De Lepeleire J. Does it make sense for the early detection of Alzheimer's disease? | Heeft het zin om de ziekte van Alzheimer vroegtijdig op te sporen? Tijdschrift Voor Geneeskunde. 70: 917-919. DOI: 10.2143/TVG.70.00.2001671  1
2014 Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, ... ... De Strooper B, et al. The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation [EMBO Mol Med, 5, (2013) 1523-1536, DOI: 10.1002/emmm.201302847] Embo Molecular Medicine. 6: 567-568. DOI: 10.1002/emmm.201470030  1
2013 Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, van den Bergh H, Ginggen A, De Strooper B, Tardy Y, Verstreken P. Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. Plos One. 8: e78562. PMID 24244323 DOI: 10.1371/journal.pone.0078562  1
2013 Tesseur I, De Strooper B. When the dust settles: what did we learn from the bexarotene discussion? Alzheimer's Research & Therapy. 5: 54. PMID 24229456 DOI: 10.1186/alzrt218  1
2013 Sala Frigerio C, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R, Wallin A, Bjerke M, Zetterberg H, Blennow K, De Strooper B. Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology. 81: 2103-6. PMID 24212398 DOI: 10.1212/01.wnl.0000437306.37850.22  1
2013 Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, ... ... De Strooper B, et al. The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. Embo Molecular Medicine. 5: 1523-36. PMID 24092663 DOI: 10.1002/emmm.201302847  1
2013 Benilova I, De Strooper B. Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner. Science (New York, N.Y.). 341: 1354-5. PMID 24052299 DOI: 10.1126/science.1244166  1
2013 Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R. Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500. Neuropharmacology. 75: 458-66. PMID 24035915 DOI: 10.1016/j.neuropharm.2013.08.030  1
2013 Lau P, Bossers K, Janky R, Salta E, Frigerio CS, Barbash S, Rothman R, Sierksma AS, Thathiah A, Greenberg D, Papadopoulou AS, Achsel T, Ayoubi T, Soreq H, Verhaagen J, ... ... De Strooper B, et al. Alteration of the microRNA network during the progression of Alzheimer's disease. Embo Molecular Medicine. 5: 1613-34. PMID 24014289 DOI: 10.1002/emmm.201201974  1
2013 Reinhard C, Borgers M, David G, De Strooper B. Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans. Journal of Cell Science. 126: 4856-61. PMID 23986479 DOI: 10.1242/jcs.137919  1
2013 Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, et al. Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12915-28, 12928a. PMID 23926248 DOI: 10.1523/JNEUROSCI.5910-12.2013  1
2013 Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De Strooper B, Balschun D, D'Hooge R. Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 109-25. PMID 23788007 DOI: 10.3233/JAD-122296  1
2013 Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G. BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 10658-63. PMID 23754390 DOI: 10.1073/pnas.1220748110  1
2013 Shariati SA, De Strooper B. Redundancy and divergence in the amyloid precursor protein family. Febs Letters. 587: 2036-45. PMID 23707420 DOI: 10.1016/j.febslet.2013.05.026  1
2013 Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M, Gijsen H, Moechars D, Mercken M, Kemp J, D'Hooge R, De Strooper B. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-e. PMID 23704554 DOI: 10.1126/science.1233937  1
2013 Soldano A, Okray Z, Janovska P, Tmejová K, Reynaud E, Claeys A, Yan J, Atak ZK, De Strooper B, Dura JM, Bryja V, Hassan BA. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. Plos Biology. 11: e1001562. PMID 23690751 DOI: 10.1371/journal.pbio.1001562  1
2013 Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P. Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. Molecular Cell. 50: 831-43. PMID 23685073 DOI: 10.1016/j.molcel.2013.04.012  0.44
2013 Mandemakers W, Abuhatzira L, Xu H, Caromile LA, Hébert SS, Snellinx A, Morais VA, Matta S, Cai T, Notkins AL, De Strooper B. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain. Diabetologia. 56: 1547-56. PMID 23595248 DOI: 10.1007/s00125-013-2901-5  1
2013 Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B. BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. Current Alzheimer Research. 10: 671-8. PMID 23566348 DOI: 10.2174/15672050113109990138  1
2013 Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B. Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice. Neurobiology of Aging. 34: 1779-89. PMID 23474291 DOI: 10.1016/j.neurobiolaging.2013.01.020  1
2013 Shariati SA, Lau P, Hassan BA, Müller U, Dotti CG, De Strooper B, Gärtner A. APLP2 regulates neuronal stem cell differentiation during cortical development. Journal of Cell Science. 126: 1268-77. PMID 23345401 DOI: 10.1242/jcs.122440  0.32
2013 Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis. 76: 49-58. PMID 23313773 DOI: 10.1016/j.jpba.2012.12.002  1
2013 Thathiah A, Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B. β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. Nature Medicine. 19: 43-9. PMID 23202293 DOI: 10.1038/nm.3023  1
2012 Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, ... ... De Strooper B, et al. Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice. Molecular Neurodegeneration. 7: 61. PMID 23249765 DOI: 10.1186/1750-1326-7-61  1
2012 BorgegÃ¥rd T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, ... ... De Strooper B, et al. Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17297-305. PMID 23197721 DOI: 10.1523/JNEUROSCI.1451-12.2012  1
2012 De Strooper B, Scorrano L. Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease. The Embo Journal. 31: 4095-7. PMID 23047154 DOI: 10.1038/emboj.2012.279  1
2012 Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, ... ... De Strooper B, et al. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron. 75: 1008-21. PMID 22998870 DOI: 10.1016/j.neuron.2012.08.022  1
2012 Vandersteen A, Masman MF, De Baets G, Jonckheere W, van der Werf K, Marrink SJ, Rozenski J, Benilova I, De Strooper B, Subramaniam V, Schymkowitz J, Rousseau F, Broersen K. Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool. The Journal of Biological Chemistry. 287: 36732-43. PMID 22992745 DOI: 10.1074/jbc.M112.394635  1
2012 Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, et al. β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. Embo Molecular Medicine. 4: 980-91. PMID 22903875 DOI: 10.1002/emmm.201101084  1
2012 De Strooper B, Voet T. Alzheimer's disease: A protective mutation. Nature. 488: 38-9. PMID 22859199 DOI: 10.1038/488038a  1
2012 Mandemakers W, Snellinx A, O'Neill MJ, de Strooper B. LRRK2 expression is enriched in the striosomal compartment of mouse striatum. Neurobiology of Disease. 48: 582-93. PMID 22850484 DOI: 10.1016/j.nbd.2012.07.017  1
2012 Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, Gevaer K, De Strooper B. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. The Journal of Biological Chemistry. 287: 25927-40. PMID 22692213 DOI: 10.1074/jbc.M112.377465  1
2012 Bezprozvanny I, Supnet C, Sun S, Zhang H, De Strooper B. Response to Shilling et al. (10.1074/jbc.M111.300491). The Journal of Biological Chemistry. 287: 20469; author reply . PMID 22685228 DOI: 10.1074/jbc.L112.356790  1
2012 Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, De Strooper B, Buée L. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7852-61. PMID 22674261 DOI: 10.1523/JNEUROSCI.5901-11.2012  1
2012 Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De Strooper B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W. Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3765-78. PMID 22661005 DOI: 10.1096/fj.11-201368  1
2012 Carmeliet P, De Strooper B. Alzheimer's disease: A breach in the blood-brain barrier. Nature. 485: 451-2. PMID 22622564 DOI: 10.1038/485451a  1
2012 Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken P. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (New York, N.Y.). 336: 1306-10. PMID 22582012 DOI: 10.1126/science.1218632  1
2012 Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, ... ... De Strooper B, et al. The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. The Embo Journal. 31: 2261-74. PMID 22505025 DOI: 10.1038/emboj.2012.79  1
2012 Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. Embo Molecular Medicine. 4: 660-73. PMID 22488900 DOI: 10.1002/emmm.201200243  1
2012 De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine. 2: a006304. PMID 22315713 DOI: 10.1101/cshperspect.a006304  1
2012 Benilova I, Karran E, De Strooper B. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nature Neuroscience. 15: 349-57. PMID 22286176 DOI: 10.1038/nn.3028  1
2012 Salta E, De Strooper B. Non-coding RNAs with essential roles in neurodegenerative disorders. The Lancet. Neurology. 11: 189-200. PMID 22265214 DOI: 10.1016/S1474-4422(11)70286-1  1
2012 Vilain S, Esposito G, Haddad D, Schaap O, Dobreva MP, Vos M, Van Meensel S, Morais VA, De Strooper B, Verstreken P. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. Plos Genetics. 8: e1002456. PMID 22242018 DOI: 10.1371/journal.pgen.1002456  1
2012 Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, Zuklys S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A. The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nature Immunology. 13: 181-7. PMID 22179202 DOI: 10.1038/ni.2193  1
2012 Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. The Journal of Biological Chemistry. 287: 1100-11. PMID 22086926 DOI: 10.1074/jbc.M111.288258  1
2012 Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin F, De Strooper B, Dotti CG, Wahle T. Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell. 11: 63-72. PMID 22023223 DOI: 10.1111/j.1474-9726.2011.00760.x  1
2012 Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, De Strooper B. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo (Journal of Biological Chemistry (2012) 287, (25927-25940)) Journal of Biological Chemistry. 287: 33719. DOI: 10.1074/jbc.A112.377465  1
2011 Thimiri Govinda Raj DB, Ghesquière B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, et al. A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Molecular Systems Biology. 7: 541. PMID 22027552 DOI: 10.1038/msb.2011.74  1
2011 Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/jbc.M111.280495  1
2011 Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proceedings of the National Academy of Sciences of the United States of America. 108: E559-68. PMID 21825135 DOI: 10.1073/pnas.1100745108  1
2011 Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. Journal of Neurochemistry. 119: 231-9. PMID 21812781 DOI: 10.1111/j.1471-4159.2011.07412.x  1
2011 Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G. Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiology of Disease. 44: 284-91. PMID 21807097 DOI: 10.1016/j.nbd.2011.07.006  1
2011 Benilova I, De Strooper B. An overlooked neurotoxic species in Alzheimer's disease. Nature Neuroscience. 14: 949-50. PMID 21792191 DOI: 10.1038/nn.2871  1
2011 Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W. Parkin interacts with Ambra1 to induce mitophagy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10249-61. PMID 21753002 DOI: 10.1523/JNEUROSCI.1917-11.2011  1
2011 Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP. Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. Blood. 118: 1163-74. PMID 21652679 DOI: 10.1182/blood-2011-04-348557  1
2011 Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M. Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo. Molecular Neurodegeneration. 6: 36. PMID 21619641 DOI: 10.1186/1750-1326-6-36  1
2011 Nelson O, Supnet C, Tolia A, Horré K, De Strooper B, Bezprozvanny I. Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. The Journal of Biological Chemistry. 286: 22339-47. PMID 21531718 DOI: 10.1074/jbc.M111.243063  1
2011 Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B. Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. Embo Molecular Medicine. 3: 291-302. PMID 21500352 DOI: 10.1002/emmm.201100138  1
2011 Brodaty H, Breteler MM, Dekosky ST, Dorenlot P, Fratiglioni L, Hock C, Kenigsberg PA, Scheltens P, De Strooper B. The world of dementia beyond 2020. Journal of the American Geriatrics Society. 59: 923-7. PMID 21488846 DOI: 10.1111/j.1532-5415.2011.03365.x  1
2011 Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. The Journal of Biological Chemistry. 286: 12271-82. PMID 21296884 DOI: 10.1074/jbc.M110.216978  1
2011 Thathiah A, De Strooper B. The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nature Reviews. Neuroscience. 12: 73-87. PMID 21248787 DOI: 10.1038/nrn2977  1
2011 Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimer's Research & Therapy. 3: 1. PMID 21211070 DOI: 10.1186/alzrt59  1
2011 Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B. Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. The Journal of Biological Chemistry. 286: 8677-87. PMID 21209097 DOI: 10.1074/jbc.M110.194860  1
2011 Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development (Cambridge, England). 138: 495-505. PMID 21205794 DOI: 10.1242/dev.055210  1
2011 Bergmans BA, Dotti CG, De Strooper B. Neuronal differentiation of murine embryonic stem cells Human Mesenchymal and Embryonic Stem Cells. 175-190.  1
2010 Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, ... ... De Strooper B, et al. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. The Embo Journal. 29: 3408-20. PMID 20818335 DOI: 10.1038/emboj.2010.211  1
2010 Jorissen E, De Strooper B. Gamma-secretase and the intramembrane proteolysis of Notch. Current Topics in Developmental Biology. 92: 201-30. PMID 20816396 DOI: 10.1016/S0070-2153(10)92006-1  1
2010 Benilova I, De Strooper B. Prion protein in Alzheimer's pathogenesis: a hot and controversial issue. Embo Molecular Medicine. 2: 289-90. PMID 20698011 DOI: 10.1002/emmm.201000088  1
2010 Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, De Strooper B. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Human Molecular Genetics. 19: 3959-69. PMID 20660113 DOI: 10.1093/hmg/ddq311  1
2010 De Strooper B, Annaert W. Novel research horizons for presenilins and γ-secretases in cell biology and disease. Annual Review of Cell and Developmental Biology. 26: 235-60. PMID 20604710 DOI: 10.1146/annurev-cellbio-100109-104117  1
2010 Annaert W, De Strooper B. Alzheimer's disease neurons fail the acid test. Cell. 141: 1112-4. PMID 20602994 DOI: 10.1016/j.cell.2010.06.009  1
2010 de Strooper B. Cancer and neurodegeneration meet. Embo Molecular Medicine. 2: 245-6. PMID 20583009 DOI: 10.1002/emmm.201000078  1
2010 Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8566-80. PMID 20573903 DOI: 10.1523/JNEUROSCI.1554-10.2010  1
2010 Morais VA, De Strooper B. Mitochondria dysfunction and neurodegenerative disorders: cause or consequence. Journal of Alzheimer's Disease : Jad. 20: S255-63. PMID 20463408 DOI: 10.3233/JAD-2010-100345  1
2010 Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D, De Strooper B. Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. Journal of Alzheimer's Disease : Jad. 20: 1119-32. PMID 20413872 DOI: 10.3233/JAD-2010-091633  1
2010 De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiological Reviews. 90: 465-94. PMID 20393191 DOI: 10.1152/physrev.00023.2009  1
2010 Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, et al. The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4833-44. PMID 20371803 DOI: 10.1523/JNEUROSCI.5221-09.2010  1
2010 De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews. Neurology. 6: 99-107. PMID 20139999 DOI: 10.1038/nrneurol.2009.218  1
2010 Bergmans BA, De Strooper B. gamma-secretases: from cell biology to therapeutic strategies. The Lancet. Neurology. 9: 215-26. PMID 20129170 DOI: 10.1016/S1474-4422(09)70332-1  1
2010 Lau P, de Strooper B. Dysregulated microRNAs in neurodegenerative disorders. Seminars in Cell & Developmental Biology. 21: 768-73. PMID 20080199 DOI: 10.1016/j.semcdb.2010.01.009  1
2010 Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B. Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation. Stem Cells (Dayton, Ohio). 28: 399-406. PMID 20049903 DOI: 10.1002/stem.296  1
2010 De Strooper B. The molecular study of Alzheimer's disease: The road to a causal treatment | De moleculaire studie van de ziekte van Alzheimer: Op weg naar een causale behandeling Tijdschrift Voor Geneeskunde. 66: 1150-1155. DOI: 10.2143/TVG.66.23.2000874  1
2009 Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W, Scorrano L, De Strooper B. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. Embo Molecular Medicine. 1: 99-111. PMID 20049710 DOI: 10.1002/emmm.200900006  1
2009 Thathiah A, De Strooper B. G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. Science Signaling. 2: re8. PMID 19843960 DOI: 10.1126/scisignal.293re8  1
2009 Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nature Cell Biology. 11: 1340-6. PMID 19838174 DOI: 10.1038/ncb1978  1
2009 Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M. Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. Plos Genetics. 5: e1000662. PMID 19779553 DOI: 10.1371/journal.pgen.1000662  1
2009 Huysseune S, Kienlen-Campard P, Hébert S, Tasiaux B, Leroy K, Devuyst O, Brion JP, De Strooper B, Octave JN. Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 4158-67. PMID 19687153 DOI: 10.1096/fj.09-140012  1
2009 Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, ... ... De Strooper B, et al. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (New York, N.Y.). 324: 639-42. PMID 19299585 DOI: 10.1126/science.1171176  1
2009 Hébert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends in Neurosciences. 32: 199-206. PMID 19268374 DOI: 10.1016/j.tins.2008.12.003  1
2009 Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a Journal of Neurology. 132: 1335-45. PMID 19251756 DOI: 10.1093/brain/awp023  1
2009 Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (New York, N.Y.). 323: 946-51. PMID 19213921 DOI: 10.1126/science.1160649  1
2009 Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B. ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. The Journal of Biological Chemistry. 284: 11738-47. PMID 19213735 DOI: 10.1074/jbc.M805894200  1
2009 Dotti CG, De Strooper B. Alzheimer's dementia by circulation disorders: when trees hide the forest. Nature Cell Biology. 11: 114-6. PMID 19188916 DOI: 10.1038/ncb0209-114  1
2009 Hébert SS, Horré K, Nicolaï L, Bergmans B, Papadopoulou AS, Delacourte A, De Strooper B. MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiology of Disease. 33: 422-8. PMID 19110058 DOI: 10.1016/j.nbd.2008.11.009  1
2009 Tolia A, De Strooper B. Structure and function of gamma-secretase. Seminars in Cell & Developmental Biology. 20: 211-8. PMID 19007897 DOI: 10.1016/j.semcdb.2008.10.007  1
2009 Benilova I, Kuperstein I, Broersen K, Schymkowitz J, Rousseau F, Bartic C, De Strooper B. MEA neurosensor, the tool for synaptic activity detection: Acute amyloid- β oligomers synaptotoxicity study Ifmbe Proceedings. 25: 314-316. DOI: 10.1007/978-3-642-03887-7-91  1
2008 O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/j.neuron.2008.10.047  1
2008 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/JNEUROSCI.2635-08.2008  1
2008 Wakabayashi T, De Strooper B. Presenilins: members of the gamma-secretase quartets, but part-time soloists too. Physiology (Bethesda, Md.). 23: 194-204. PMID 18697993 DOI: 10.1152/physiol.00009.2008  1
2008 Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proceedings of the National Academy of Sciences of the United States of America. 105: 9775-80. PMID 18626010 DOI: 10.1073/pnas.0800507105  1
2008 Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. Experimental Cell Research. 314: 2419-33. PMID 18559276 DOI: 10.1016/j.yexcr.2008.05.003  1
2008 Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B. Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. The Journal of Biological Chemistry. 283: 20096-105. PMID 18502756 DOI: 10.1074/jbc.M803040200  1
2008 Tolia A, Horré K, De Strooper B. Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase. The Journal of Biological Chemistry. 283: 19793-803. PMID 18482978 DOI: 10.1074/jbc.M802461200  1
2008 Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proceedings of the National Academy of Sciences of the United States of America. 105: 6415-20. PMID 18434550 DOI: 10.1073/pnas.0710263105  1
2008 Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F. Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. The Embo Journal. 27: 224-33. PMID 18059472 DOI: 10.1038/sj.emboj.7601953  1
2007 Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/jbc.M705248200  1
2007 Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. The Journal of Pharmacology and Experimental Therapeutics. 323: 822-30. PMID 17895400 DOI: 10.1124/jpet.107.129007  1
2007 Hébert SS, De Strooper B. Molecular biology. miRNAs in neurodegeneration. Science (New York, N.Y.). 317: 1179-80. PMID 17761871 DOI: 10.1126/science.1148530  1
2007 Mandemakers W, Morais VA, De Strooper B. A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. Journal of Cell Science. 120: 1707-16. PMID 17502481 DOI: 10.1242/jcs.03443  1
2007 Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. The Journal of Clinical Investigation. 117: 1230-9. PMID 17431506 DOI: 10.1172/JCI30447  1
2007 Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. The Journal of Biological Chemistry. 282: 11982-95. PMID 17307738 DOI: 10.1074/jbc.M700356200  1
2007 Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death and Differentiation. 14: 1040-9. PMID 17290285 DOI: 10.1038/sj.cdd.4402101  1
2007 De Strooper B. Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. Embo Reports. 8: 141-6. PMID 17268505 DOI: 10.1038/sj.embor.7400897  1
2007 Wakabayashi T, Iwatsubo T, De Strooper B. The biology of the presenilin complexes Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 35-58. DOI: 10.1007/978-0-387-35135-3_3  1
2007 De Strooper B. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 403-405.  1
2006 Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 126: 981-93. PMID 16959576 DOI: 10.1016/j.cell.2006.06.059  1
2006 Theuns J, Marjaux E, Vandenbulcke M, Van Laere K, Kumar-Singh S, Bormans G, Brouwers N, Van den Broeck M, Vennekens K, Corsmit E, Cruts M, De Strooper B, Van Broeckhoven C, Vandenberghe R. Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment. Human Mutation. 27: 888-96. PMID 16917905 DOI: 10.1002/humu.20402  1
2006 Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. The Journal of Biological Chemistry. 281: 26569-77. PMID 16846981 DOI: 10.1074/jbc.M600592200  1
2006 Tolia A, Chávez-Gutiérrez L, De Strooper B. Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex. The Journal of Biological Chemistry. 281: 27633-42. PMID 16844686 DOI: 10.1074/jbc.M604997200  1
2006 Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko GV, Rudka T, Bartoli D, Polishuck RS, Danial NN, De Strooper B, Scorrano L. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell. 126: 177-89. PMID 16839885 DOI: 10.1016/j.cell.2006.06.025  1
2006 Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, ... De Strooper B, et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell. 126: 163-75. PMID 16839884 DOI: 10.1016/j.cell.2006.06.021  1
2006 Avila J, Nitsch RM, Haass C, De Strooper B. European Alzheimer disease funding. Nature Medicine. 12: 776-7. PMID 16829945 DOI: 10.1038/nm0706-776  1
2006 Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA, Müller U, De Strooper B. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. Embo Reports. 7: 739-45. PMID 16729020 DOI: 10.1038/sj.embor.7400704  1
2006 Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. Journal of Neurochemistry. 96: 732-42. PMID 16405513 DOI: 10.1111/j.1471-4159.2005.03578.x  1
2006 Debrock S, De Strooper B, Vander Perre S, Hill JA, D'Hooghe TM. Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model. Human Reproduction (Oxford, England). 21: 605-9. PMID 16253962 DOI: 10.1093/humrep/dei375  1
2005 Reinhard C, Hébert SS, De Strooper B. The amyloid-beta precursor protein: integrating structure with biological function. The Embo Journal. 24: 3996-4006. PMID 16252002 DOI: 10.1038/sj.emboj.7600860  1
2005 Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M, Tschäpe JA, De Strooper B, Müller U, Shen J, Hartmann T. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nature Cell Biology. 7: 1118-23. PMID 16227967 DOI: 10.1038/ncb1313  1
2005 De Strooper B. Nicastrin: gatekeeper of the gamma-secretase complex. Cell. 122: 318-20. PMID 16096051 DOI: 10.1016/j.cell.2005.07.021  1
2005 Leyssen M, Ayaz D, Hébert SS, Reeve S, De Strooper B, Hassan BA. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. The Embo Journal. 24: 2944-55. PMID 16052209 DOI: 10.1038/sj.emboj.7600757  1
2005 Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, ... ... De Strooper B, et al. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. The Journal of Biological Chemistry. 280: 30797-806. PMID 15987683 DOI: 10.1074/jbc.M505249200  1
2005 Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9182-7. PMID 15958533 DOI: 10.1073/pnas.0500918102  1
2005 Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental Cell. 8: 677-88. PMID 15866159 DOI: 10.1016/j.devcel.2005.02.019  1
2005 Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N. beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. The Journal of Biological Chemistry. 280: 23009-17. PMID 15824102 DOI: 10.1074/jbc.M414648200  1
2005 Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. The Journal of Biological Chemistry. 280: 19070-7. PMID 15764596 DOI: 10.1074/jbc.M501130200  1
2005 Coolen MW, Van Loo KM, Van Bakel NN, Pulford DJ, Serneels L, De Strooper B, Ellenbroek BA, Cools AR, Martens GJ. Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders. Neuron. 45: 497-503. PMID 15721236 DOI: 10.1016/j.neuron.2004.12.054  1
2005 Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P. ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. The Embo Journal. 24: 742-52. PMID 15692570 DOI: 10.1038/sj.emboj.7600548  1
2005 Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 1719-24. PMID 15665098 DOI: 10.1073/pnas.0408901102  1
2005 Winters K, De Keersmaecker K, Bartic C, Braeken D, De Strooper B, Borghs G. Neuronal lithography with single cell resolution on chemically and topographically functionalised surfaces Proceedings of Spie - the International Society For Optical Engineering. 5839: 410-419. DOI: 10.1117/12.608208  1
2004 Dominguez DI, Hartmann D, De Strooper B. BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease. Neuro-Degenerative Diseases. 1: 168-74. PMID 16908986 DOI: 10.1159/000080982  1
2004 Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG. Neuronal membrane cholesterol loss enhances amyloid peptide generation. The Journal of Cell Biology. 167: 953-60. PMID 15583033 DOI: 10.1083/jcb.200404149  1
2004 Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B. Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10908-17. PMID 15574741 DOI: 10.1523/JNEUROSCI.3987-04.2004  1
2004 Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiology of Disease. 17: 260-72. PMID 15474363 DOI: 10.1016/j.nbd.2004.08.002  1
2004 Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. The Journal of Cell Biology. 166: 1041-54. PMID 15452145 DOI: 10.1083/jcb.200406060  1
2004 Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000). 40: 40-4. PMID 15354292 DOI: 10.1002/gene.20061  1
2004 Wrigley JD, Nunn EJ, Nyabi O, Clarke EE, Hunt P, Nadin A, De Strooper B, Shearman MS, Beher D. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding. Journal of Neurochemistry. 90: 1312-20. PMID 15341515 DOI: 10.1111/j.1471-4159.2004.02596.x  1
2004 Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H. Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. The Journal of Cell Biology. 165: 893-902. PMID 15197174 DOI: 10.1083/jcb.200310024  1
2004 Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, Saftig P, Craessaerts K, De Strooper B, Hartmann D. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Human Molecular Genetics. 13: 1321-31. PMID 15128703 DOI: 10.1093/hmg/ddh151  1
2004 Marjaux E, Hartmann D, De Strooper B. Presenilins in memory, Alzheimer's disease, and therapy. Neuron. 42: 189-92. PMID 15091335 DOI: 10.1016/S0896-6273(04)00218-1  1
2004 Dejaegere T, de Strooper B. [Secretases as therapeutic targets for the treatment of Alzheimer's disease]. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van België. 66: 29-58; discussion 58. PMID 15074081  1
2004 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T. Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. The Journal of Biological Chemistry. 279: 24343-54. PMID 15037614 DOI: 10.1074/jbc.M401925200  1
2004 Marjaux E, De Strooper B. γ-secretase inhibitors: Still in the running as Alzheimer's therapeutics Drug Discovery Today: Therapeutic Strategies. 1: 1-6. DOI: 10.1016/j.ddstr.2004.05.001  1
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/pnas.1735338100  1
2003 Moreau Y, Aerts S, De Moor B, De Strooper B, Dabrowski M. Comparison and meta-analysis of microarray data: from the bench to the computer desk. Trends in Genetics : Tig. 19: 570-7. PMID 14550631 DOI: 10.1016/j.tig.2003.08.006  1
2003 Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. The Journal of Biological Chemistry. 278: 48713-9. PMID 14507929 DOI: 10.1074/jbc.M303861200  1
2003 Schulz JG, Annaert W, Vandekerckhove J, Zimmermann P, De Strooper B, David G. Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. The Journal of Biological Chemistry. 278: 48651-7. PMID 14504279 DOI: 10.1074/jbc.M308424200  1
2003 Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B, Baekelandt V. Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain Pathology (Zurich, Switzerland). 13: 364-72. PMID 12946025  1
2003 Kahle PJ, De Strooper B. Attack on amyloid. Embo Reports. 4: 747-51. PMID 12897797 DOI: 10.1038/sj.embor.embor905  1
2003 Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. The Journal of Biological Chemistry. 278: 43430-6. PMID 12885769 DOI: 10.1074/jbc.M306957200  1
2003 De Strooper B, Woodgett J. Alzheimer's disease: Mental plaque removal. Nature. 423: 392-3. PMID 12761533 DOI: 10.1038/423392a  1
2003 Dabrowski M, Aerts S, Van Hummelen P, Craessaerts K, De Moor B, Annaert W, Moreau Y, De Strooper B. Gene profiling of hippocampal neuronal culture. Journal of Neurochemistry. 85: 1279-88. PMID 12753086 DOI: 10.1046/j.1471-4159.2003.01753.x  1
2003 De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron. 38: 9-12. PMID 12691659 DOI: 10.1016/S0896-6273(03)00205-8  1
2003 Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298  1
2003 Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. Journal of Cell Science. 116: 1127-36. PMID 12584255 DOI: 10.1242/jcs.00292  1
2002 Kumar-Singh S, Julliams A, Nuydens R, Ceuterick C, Labeur C, Serneels S, Vennekens K, Van Osta P, Geerts H, De Strooper B, Van Broeckhoven C. In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity. Neurobiology of Disease. 11: 330-40. PMID 12505425 DOI: 10.1006/nbdi.2002.0529  1
2002 Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Human Molecular Genetics. 11: 2615-24. PMID 12354787  1
2002 Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 110: 751-62. PMID 12297048 DOI: 10.1016/S0092-8674(02)00970-4  1
2002 Annaert W, De Strooper B. A cell biological perspective on Alzheimer's disease. Annual Review of Cell and Developmental Biology. 18: 25-51. PMID 12142279 DOI: 10.1146/annurev.cellbio.18.020402.142302  1
2002 Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B. No endogenous A beta production in presenilin-deficient fibroblasts. Nature Cell Biology. 4: E164; author reply E. PMID 12105423 DOI: 10.1038/ncb0702-e164a  1
2002 Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B, Nuttin B, Debyser Z. Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Human Gene Therapy. 13: 841-53. PMID 11975850 DOI: 10.1089/10430340252899019  1
2002 Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage MJ, Annaert WG, De Strooper B, Siman R, Scott RW. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. Neurobiology of Aging. 23: 335-48. PMID 11959395 DOI: 10.1016/S0197-4580(01)00330-X  1
2002 Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America. 99: 4697-702. PMID 11917117 DOI: 10.1073/pnas.072033799  1
2001 Sisodia SS, Annaert W, Kim SH, De Strooper B. Gamma-secretase: never more enigmatic. Trends in Neurosciences. 24: S2-6. PMID 11881741  1
2001 Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Implication of APP secretases in notch signaling. Journal of Molecular Neuroscience : Mn. 17: 171-81. PMID 11816790 DOI: 10.1385/JMN:17:2:171  0.32
2001 Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron. 32: 579-89. PMID 11719200  0.44
2001 Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. Journal of Neurochemistry. 78: 1168-78. PMID 11553691  0.44
2001 Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. The Journal of Biological Chemistry. 276: 42645-57. PMID 11526104 DOI: 10.1074/jbc.M102790200  0.32
2001 Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. The Journal of Cell Biology. 154: 731-40. PMID 11502763 DOI: 10.1083/jcb.200104045  0.44
2001 De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. Human Molecular Genetics. 10: 1665-71. PMID 11487570  0.44
2001 Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F. The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. The Journal of Biological Chemistry. 276: 37743-6. PMID 11477090 DOI: 10.1074/jbc.M105677200  0.32
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  1
2001 Dominguez DI, De Strooper B, Annaert W. Secretases as therapeutic targets for the treatment of Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 124-42. PMID 11409035  0.32
2001 De Strooper B, Annaert W. Where Notch and Wnt signaling meet. The presenilin hub. The Journal of Cell Biology. 152: F17-20. PMID 11266476  0.32
2001 Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B. Processing of beta-secretase by furin and other members of the proprotein convertase family. The Journal of Biological Chemistry. 276: 4211-7. PMID 11071887 DOI: 10.1074/jbc.M006947200  0.6
2000 Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG. Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. Embo Reports. 1: 530-5. PMID 11263499 DOI: 10.1093/embo-reports/kvd107  1
2000 Baekelandt V, De Strooper B, Nuttin B, Debyser Z. Gene therapeutic strategies for neurodegenerative diseases. Current Opinion in Molecular Therapeutics. 2: 540-54. PMID 11249757  0.68
2000 Annaert W, Cupers P, Saftig P, De Strooper B. Presenilin function in APP processing. Annals of the New York Academy of Sciences. 920: 158-64. PMID 11193144  0.32
2000 Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z. DNA-Dependent protein kinase is not required for efficient lentivirus integration. Journal of Virology. 74: 11278-85. PMID 11070027  0.68
2000 Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C. Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Human Molecular Genetics. 9: 2589-98. PMID 11063718  0.32
2000 Annaert W, De Strooper B. Neuronal models to study amyloid precursor protein expression and processing in vitro. Biochimica Et Biophysica Acta. 1502: 53-62. PMID 10899431  0.32
2000 Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B. Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nature Cell Biology. 2: 461-2. PMID 10878813 DOI: 10.1038/35017105  0.6
2000 De Strooper B, Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. Journal of Cell Science. 113: 1857-70. PMID 10806097  0.32
1999 Saftig P, Hartmann D, De Strooper B. The function of presenilin-1 in amyloid beta-peptide generation and brain development. European Archives of Psychiatry and Clinical Neuroscience. 249: 271-9. PMID 10653282  0.32
1999 Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. The Journal of Cell Biology. 147: 277-94. PMID 10525535  0.44
1999 Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, ... ... De Strooper B, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 11872-7. PMID 10518543 DOI: 10.1073/pnas.96.21.11872  1
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657  1
1999 Annaert W, De Strooper B. Presenilins: molecular switches between proteolysis and signal transduction. Trends in Neurosciences. 22: 439-43. PMID 10481190  0.32
1999 Hartmann D, De Strooper B, Saftig P. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Current Biology : Cb. 9: 719-27. PMID 10421573  0.32
1999 De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398: 518-22. PMID 10206645 DOI: 10.1038/19083  1
1998 Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 395: 698-702. PMID 9790190 DOI: 10.1038/27208  1
1998 Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F. Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. Behavioural Brain Research. 95: 55-64. PMID 9754877 DOI: 10.1016/S0166-4328(97)00210-6  1
1998 Saftig P, de Strooper B. Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes. Molecular Psychiatry. 3: 287-9. PMID 9702732  0.32
1998 Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 6460-4. PMID 9600988 DOI: 10.1073/pnas.95.11.6460  1
1998 De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391: 387-90. PMID 9450754 DOI: 10.1038/34910  1
1997 De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. The Journal of Biological Chemistry. 272: 3590-8. PMID 9013610 DOI: 10.1074/jbc.272.6.3590  1
1996 Tienari PJ, De Strooper B, Ikonen E, Ida N, Simons M, Masters CL, Dotti CG, Beyreuther K. Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 575-85. PMID 9246484  1
1996 De Strooper B, Wu RR, Jaspers M, Van der Schueren B, Vekemans S, Carmeliet G, Van Leuven F, Van Den Oord J, Cassiman JJ. A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes. Dermatology (Basel, Switzerland). 193: 212-20. PMID 8944343  1
1996 Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. The Journal of Biological Chemistry. 271: 27241-4. PMID 8910296 DOI: 10.1074/jbc.271.44.27241  1
1996 Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. The Embo Journal. 15: 5218-29. PMID 8895567  1
1996 Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. The Embo Journal. 15: 1265-74. PMID 8635459  1
1996 Simons M, de Strooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K. Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 899-908. PMID 8558258  1
1995 De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 30310-4. PMID 8530453  1
1995 De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. The Journal of Biological Chemistry. 270: 4058-65. PMID 7876155  1
1995 De Strooper B, Creemers JW, Moechars D, Huylebroeck D, Van De Ven WJ, Van Leuven F, Van den Berghe H. Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. Biochimica Et Biophysica Acta. 1246: 185-8. PMID 7819286  1
1995 Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. Genomics. 25: 492-500. PMID 7789983  1
1995 Van Gool D, De Strooper B, Van Leuven F, Dom R. Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. Dementia (Basel, Switzerland). 6: 63-8. PMID 7606281  1
1995 De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. The Embo Journal. 14: 4932-8. PMID 7588622  1
1995 Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 65: 1009-25. PMID 7542371  1
1994 Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B. Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. Genomics. 24: 78-89. PMID 7534747  1
1994 Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H. Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells. Genomics. 22: 519-29. PMID 7528166 DOI: 10.1006/geno.1994.1425  1
1993 Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S. Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. Biochimica Et Biophysica Acta. 1173: 71-4. PMID 8485155  1
1993 De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway. The Journal of Cell Biology. 121: 295-304. PMID 8468348  1
1993 Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiology of Aging. 14: 233-7. PMID 7686641  1
1993 De Strooper B, Van Leuven F. Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease. Immunology Today. 14: 143-4. PMID 7682079  1
1993 Jaspers M, Vekemans S, Carmeliet G, van Leuven F, de Strooper B, Deckmyn H, Cassiman JJ. A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen. Hybridoma. 12: 467-74. PMID 7503943  1
1992 Delabie J, Shipman R, Brüggen J, De Strooper B, van Leuven F, Tarcsay L, Cerletti N, Odink K, Diehl V, Bilbe G. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. Blood. 80: 2891-6. PMID 1450414  1
1992 De Strooper B, Van Leuven F, Van den Berghe H. Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells. Febs Letters. 308: 50-3. PMID 1379551  1
1992 van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H. The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA. European Journal of Biochemistry / Febs. 210: 319-27. PMID 1280217  1
1991 De Strooper B, Van Leuven F, Carmeliet G, Van Den Berghe H, Cassiman JJ. Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit. European Journal of Biochemistry / Febs. 199: 25-33. PMID 1906002  1
1991 De Strooper B, Van Leuven F, Van den Berghe H. The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochimica Et Biophysica Acta. 1129: 141-3. PMID 1756177  1
1989 De Strooper B, Van der Schueren B, Jaspers M, Saison M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Distribution of the beta 1 subgroup of the integrins in human cells and tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 299-307. PMID 2645360  1
1988 De Strooper B, Saison M, Jaspers M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor. Cell Biology International Reports. 12: 9-16. PMID 2969294  1
1988 Jaspers M, de Strooper B, Spaepen M, van Leuven F, David G, van den Berghe H, Cassiman JJ. Post-translational modification of the beta-subunit of the human fibronectin receptor. Febs Letters. 231: 402-6. PMID 2966078  1
1988 Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ. Mapping of human fibronectin receptor beta subunit gene to chromosome 10. Somatic Cell and Molecular Genetics. 14: 99-104. PMID 2963381  1
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