☰

Bart De Strooper - Publications

Affiliations: 
Laboratory of Neuronal Cell Biology and Gene Transfer  Katholieke Universiteit Leuven, Leuven, Vlaanderen, Belgium 
Website:
http://med.kuleuven.be/cme-mg/lncb/index.html
Tree Info Grants Similar researchers PubMed Report error

133/411 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Mancuso R, Fattorelli N, Martinez-Muriana A, Davis E, Wolfs L, Van Den Daele J, Geric I, Premereur J, Polanco P, Bijnens B, Preman P, Serneels L, Poovathingal S, Balusu S, Verfaillie C, ... ... De Strooper B, et al. Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology. Nature Neuroscience. PMID 38539015 DOI: 10.1038/s41593-024-01600-y  0.322
2024 De Strooper B, Karran E. New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases. The Embo Journal. PMID 38396302 DOI: 10.1038/s44318-024-00057-w  0.34
2023 Hou P, Zielonka M, Serneels L, Martinez-Muriana A, Fattorelli N, Wolfs L, Poovathingal S, T'Syen D, Balusu S, Theys T, Fiers M, Mancuso R, Howden AJM, De Strooper B. The γ-secretase substrate proteome and its role in cell signaling regulation. Molecular Cell. 83: 4106-4122.e10. PMID 37977120 DOI: 10.1016/j.molcel.2023.10.029  0.334
2023 Aghaizu ND, Jolly S, Samra SK, Kalmar B, Craessaerts K, Greensmith L, Salinas PC, De Strooper B, Whiting PJ. Microglial Expression of the Wnt Signaling Modulator Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models. Eneuro. 10. PMID 36599670 DOI: 10.1523/ENEURO.0306-22.2022  0.364
2022 Moonen S, Koper MJ, Van Schoor E, Schaeverbeke JM, Vandenberghe R, von Arnim CAF, Tousseyn T, De Strooper B, Thal DR. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons. Acta Neuropathologica. 145: 175-195. PMID 36481964 DOI: 10.1007/s00401-022-02528-y  0.355
2022 Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, ... ... de Strooper B, et al. Microglia states and nomenclature: A field at its crossroads. Neuron. 110: 3458-3483. PMID 36327895 DOI: 10.1016/j.neuron.2022.10.020  0.427
2022 Koper MJ, Tomé SO, Gawor K, Belet A, Van Schoor E, Schaeverbeke J, Vandenberghe R, Vandenbulcke M, Ghebremedhin E, Otto M, von Arnim CAF, Balusu S, Blaschko MB, De Strooper B, Thal DR. LATE-NC aggravates GVD-mediated necroptosis in Alzheimer's disease. Acta Neuropathologica Communications. 10: 128. PMID 36057624 DOI: 10.1186/s40478-022-01432-6  0.329
2022 Karran E, De Strooper B. The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics. Nature Reviews. Drug Discovery. PMID 35177833 DOI: 10.1038/s41573-022-00391-w  0.336
2021 Benitez DP, Jiang S, Wood J, Wang R, Hall CM, Peerboom C, Wong N, Stringer KM, Vitanova KS, Smith VC, Joshi D, Saito T, Saido TC, Hardy J, Hanrieder J, ... De Strooper B, et al. Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia. Molecular Neurodegeneration. 16: 47. PMID 34266459 DOI: 10.1186/s13024-021-00457-0  0.328
2021 Vandenabeele M, Veys L, Lemmens S, Hadoux X, Gelders G, Masin L, Serneels L, Theunis J, Saito T, Saido TC, Jayapala M, De Boever P, De Strooper B, Stalmans I, van Wijngaarden P, et al. The App mouse retina is a site for preclinical Alzheimer's disease diagnosis and research. Acta Neuropathologica Communications. 9: 6. PMID 33407903 DOI: 10.1186/s40478-020-01102-5  0.309
2020 Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, et al. A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathologica. PMID 33319314 DOI: 10.1007/s00401-020-02249-0  0.355
2020 Chen WT, Lu A, Craessaerts K, Pavie B, Sala Frigerio C, Corthout N, Qian X, Laláková J, Kühnemund M, Voytyuk I, Wolfs L, Mancuso R, Salta E, Balusu S, Snellinx A, ... ... De Strooper B, et al. Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease. Cell. PMID 32702314 DOI: 10.1016/j.cell.2020.06.038  0.314
2020 Harris SS, Wolf F, De Strooper B, Busche MA. Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron. PMID 32579881 DOI: 10.1016/J.Neuron.2020.06.005  0.344
2020 Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, et al. The β-Secretase BACE1 in Alzheimer's Disease. Biological Psychiatry. PMID 32223911 DOI: 10.1016/J.Biopsych.2020.02.001  0.394
2020 Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology. Embo Molecular Medicine. e10606. PMID 31951107 DOI: 10.15252/Emmm.201910606  0.304
2020 Rice HC, Marcassa G, Chrysidou I, Horré K, Young-Pearse TL, Müller UC, Saito T, Saido TC, Vassar R, de Wit J, De Strooper B. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Molecular Neurodegeneration. 15: 3. PMID 31915042 DOI: 10.1186/S13024-019-0356-Y  0.4
2019 Koper MJ, Van Schoor E, Ospitalieri S, Vandenberghe R, Vandenbulcke M, von Arnim CAF, Tousseyn T, Balusu S, De Strooper B, Thal DR. Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer's disease. Acta Neuropathologica. PMID 31802237 DOI: 10.1007/S00401-019-02103-Y  0.34
2019 Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, ... ... De Strooper B, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/J.Celrep.2019.03.099  0.312
2018 Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B. Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice. Journal of Alzheimer's Disease : Jad. PMID 30320577 DOI: 10.3233/Jad-180410  0.318
2018 Shah D, Latif-Hernandez A, De Strooper B, Saito T, Saido T, Verhoye M, D'Hooge R, Van der Linden A. Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APP knock-in mice. Scientific Reports. 8: 6264. PMID 29674739 DOI: 10.1038/S41598-018-24657-9  0.314
2017 Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC. APP mouse models for Alzheimer's disease preclinical studies. The Embo Journal. PMID 28768718 DOI: 10.15252/Embj.201797397  0.386
2017 Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, ... De Strooper B, et al. Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions. Cell. 170: 443-456.e14. PMID 28753424 DOI: 10.1016/J.Cell.2017.07.004  0.334
2017 Acx H, Serneels L, Radaelli E, Muyldermans S, Vincke C, Pepermans E, Müller U, Chávez-Gutiérrez L, De Strooper B. Inactivation of γ-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. Embo Molecular Medicine. PMID 28588032 DOI: 10.15252/emmm.201707561  0.338
2017 Brownjohn PW, Smith J, Portelius E, Serneels L, Kvartsberg H, De Strooper B, Blennow K, Zetterberg H, Livesey FJ. Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease. Stem Cell Reports. PMID 28285880 DOI: 10.1016/j.stemcr.2017.02.006  0.349
2017 Guix FX, Sannerud R, Berditchevski F, Arranz AM, Horré K, Snellinx A, Thathiah A, Saido T, Saito T, Rajesh S, Overduin M, Kumar-Singh S, Radaelli E, Corthout N, Colombelli J, ... ... De Strooper B, et al. Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments. Molecular Neurodegeneration. 12: 25. PMID 28279219 DOI: 10.1186/S13024-017-0165-0  0.326
2017 Espuny-Camacho I, Arranz AM, Fiers M, Snellinx A, Ando K, Munck S, Bonnefont J, Lambot L, Corthout N, Omodho L, Vanden Eynden E, Radaelli E, Tesseur I, Wray S, Ebneth A, ... ... De Strooper B, et al. Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain. Neuron. PMID 28238547 DOI: 10.1016/J.Neuron.2017.02.001  0.695
2017 Timmers M, Barão S, Van Broeck B, Tesseur I, Slemmon J, De Waepenaert K, Bogert J, Shaw LM, Engelborghs S, Moechars D, Mercken M, Van Nueten L, Tritsmans L, de Strooper B, Streffer JR. BACE1 Dynamics Upon Inhibition with a BACE Inhibitor and Correlation to Downstream Alzheimer's Disease Markers in Elderly Healthy Participants. Journal of Alzheimer's Disease : Jad. PMID 28157093 DOI: 10.3233/Jad-160829  0.7
2016 Gallardo R, Ramakers M, De Smet F, Claes F, Khodaparast L, Khodaparast L, Couceiro JR, Langenberg T, Siemons M, Nyström S, Young LJ, Laine RF, Young L, Radaelli E, Benilova I, ... ... De Strooper B, et al. De novo design of a biologically active amyloid. Science (New York, N.Y.). 354. PMID 27846578 DOI: 10.1126/Science.Aah4949  0.308
2016 Sannerud R, Esselens C, Ejsmont P, Mattera R, Rochin L, Tharkeshwar AK, De Baets G, De Wever V, Habets R, Baert V, Vermeire W, Michiels C, Groot AJ, Wouters R, Dillen K, ... ... De Strooper B, et al. Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool. Cell. PMID 27293189 DOI: 10.1016/J.Cell.2016.05.020  0.355
2016 Karran E, De Strooper B. The amyloid cascade hypothesis: are we poised for success or failure? Journal of Neurochemistry. PMID 27255958 DOI: 10.1111/jnc.13632  0.324
2016 Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM. Alzheimer's disease. Lancet (London, England). PMID 26921134 DOI: 10.1016/S0140-6736(15)01124-1  0.313
2016 De Strooper B, Karran E. The Cellular Phase of Alzheimer's Disease. Cell. 164: 603-15. PMID 26871627 DOI: 10.1016/j.cell.2015.12.056  0.309
2016 Barão S, Moechars D, Lichtenthaler SF, De Strooper B. BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease. Trends in Neurosciences. PMID 26833257 DOI: 10.1016/j.tins.2016.01.003  0.35
2015 Szaruga M, Veugelen S, Benurwar M, Lismont S, Sepulveda-Falla D, Lleo A, Ryan NS, Lashley T, Fox NC, Murayama S, Gijsen H, De Strooper B, Chávez-Gutiérrez L. Qualitative changes in human γ-secretase underlie familial Alzheimer's disease. The Journal of Experimental Medicine. PMID 26481686 DOI: 10.1084/Jem.20150892  0.328
2015 Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, ... ... De Strooper B, et al. Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models. Science Translational Medicine. 7: 309ra164. PMID 26468326 DOI: 10.1126/Scitranslmed.Aab3492  0.423
2015 Brkic M, Balusu S, Van Wonterghem E, Gorlé N, Benilova I, Kremer A, Van Hove I, Moons L, De Strooper B, Kanazir S, Libert C, Vandenbroucke RE. Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 12766-78. PMID 26377465 DOI: 10.1523/JNEUROSCI.0006-15.2015  0.341
2014 Benilova I, Gallardo R, Ungureanu AA, Castillo Cano V, Snellinx A, Ramakers M, Bartic C, Rousseau F, Schymkowitz J, De Strooper B. The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation. The Journal of Biological Chemistry. 289: 30977-89. PMID 25253695 DOI: 10.1074/jbc.M114.599027  0.328
2014 Serneels L, Tesseur I, De Strooper B. Assay to probe proteolytic processing of Notch by γ-secretase. Methods in Molecular Biology (Clifton, N.J.). 1187: 223-9. PMID 25053493 DOI: 10.1007/978-1-4939-1139-4_17  0.644
2014 Pimenova AA, Thathiah A, De Strooper B, Tesseur I. Regulation of amyloid precursor protein processing by serotonin signaling. Plos One. 9: e87014. PMID 24466315 DOI: 10.1371/Journal.Pone.0087014  0.706
2013 Tesseur I, De Strooper B. When the dust settles: what did we learn from the bexarotene discussion? Alzheimer's Research & Therapy. 5: 54. PMID 24229456 DOI: 10.1186/Alzrt218  0.689
2013 Benilova I, De Strooper B. Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner. Science (New York, N.Y.). 341: 1354-5. PMID 24052299 DOI: 10.1126/science.1244166  0.312
2013 Lo AC, Tesseur I, Scopes DI, Nerou E, Callaerts-Vegh Z, Vermaercke B, Treherne JM, De Strooper B, D'Hooge R. Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500. Neuropharmacology. 75: 458-66. PMID 24035915 DOI: 10.1016/J.Neuropharm.2013.08.030  0.673
2013 Lo AC, Iscru E, Blum D, Tesseur I, Callaerts-Vegh Z, Buée L, De Strooper B, Balschun D, D'Hooge R. Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 37: 109-25. PMID 23788007 DOI: 10.3233/Jad-122296  0.702
2013 Rochin L, Hurbain I, Serneels L, Fort C, Watt B, Leblanc P, Marks MS, De Strooper B, Raposo G, van Niel G. BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 10658-63. PMID 23754390 DOI: 10.1073/pnas.1220748110  0.374
2013 Tesseur I, Lo AC, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M, Gijsen H, Moechars D, Mercken M, Kemp J, D'Hooge R, De Strooper B. Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science (New York, N.Y.). 340: 924-e. PMID 23704554 DOI: 10.1126/science.1233937  0.691
2013 Barao S, Zhou L, Adamczuk K, Vanhoutvin T, van Leuven F, Demedts D, Vijverman AC, Bossuyt X, Vandenberghe R, De Strooper B. BACE1 levels correlate with phospho-tau levels in human cerebrospinal fluid. Current Alzheimer Research. 10: 671-8. PMID 23566348 DOI: 10.2174/15672050113109990138  0.518
2013 Tesseur I, Pimenova AA, Lo AC, Ciesielska M, Lichtenthaler SF, De Maeyer JH, Schuurkes JA, D'Hooge R, De Strooper B. Chronic 5-HT4 receptor activation decreases Aβ production and deposition in hAPP/PS1 mice. Neurobiology of Aging. 34: 1779-89. PMID 23474291 DOI: 10.1016/J.Neurobiolaging.2013.01.020  0.675
2013 Thathiah A, Horré K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B. β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease. Nature Medicine. 19: 43-9. PMID 23202293 DOI: 10.1038/nm.3023  0.351
2013 Tesseur I, Lo A, Roberfroid A, Dietvorst S, Van Broeck B, Borgers M, Gijsen H, Moechars D, Mercken M, Kemp J, D’Hooge R, De Strooper B. Bexarotene treatment does not clear β-Amyloid in an AD mouse model and Beagle dogs Molecular Neurodegeneration. 8: P40. DOI: 10.1186/1750-1326-8-S1-P40  0.685
2012 Rogers K, Felsenstein KM, Hrdlicka L, Tu Z, Albayya F, Lee W, Hopp S, Miller MJ, Spaulding D, Yang Z, Hodgdon H, Nolan S, Wen M, Costa D, Blain JF, ... ... De Strooper B, et al. Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice. Molecular Neurodegeneration. 7: 61. PMID 23249765 DOI: 10.1186/1750-1326-7-61  0.348
2012 BorgegÃ¥rd T, Gustavsson S, Nilsson C, Parpal S, Klintenberg R, Berg AL, Rosqvist S, Serneels L, Svensson S, Olsson F, Jin S, Yan H, Wanngren J, Jureus A, Ridderstad-Wollberg A, ... ... De Strooper B, et al. Alzheimer's disease: presenilin 2-sparing γ-secretase inhibition is a tolerable Aβ peptide-lowering strategy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 17297-305. PMID 23197721 DOI: 10.1523/Jneurosci.1451-12.2012  0.327
2012 Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. Embo Molecular Medicine. 4: 660-73. PMID 22488900 DOI: 10.1002/Emmm.201200243  0.345
2012 De Strooper B, Iwatsubo T, Wolfe MS. Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harbor Perspectives in Medicine. 2: a006304. PMID 22315713 DOI: 10.1101/cshperspect.a006304  0.35
2012 Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization. The Journal of Biological Chemistry. 287: 1100-11. PMID 22086926 DOI: 10.1074/Jbc.M111.288258  0.326
2011 Moss ML, Powell G, Miller MA, Edwards L, Qi B, Sang QX, De Strooper B, Tesseur I, Lichtenthaler SF, Taverna M, Zhong JL, Dingwall C, Ferdous T, Schlomann U, Zhou P, et al. ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. The Journal of Biological Chemistry. 286: 40443-51. PMID 21956108 DOI: 10.1074/Jbc.M111.280495  0.684
2011 Sannerud R, Declerck I, Peric A, Raemaekers T, Menendez G, Zhou L, Veerle B, Coen K, Munck S, De Strooper B, Schiavo G, Annaert W. ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proceedings of the National Academy of Sciences of the United States of America. 108: E559-68. PMID 21825135 DOI: 10.1073/Pnas.1100745108  0.336
2011 Rabe S, Reichwald J, Ammaturo D, de Strooper B, Saftig P, Neumann U, Staufenbiel M. The Swedish APP mutation alters the effect of genetically reduced BACE1 expression on the APP processing. Journal of Neurochemistry. 119: 231-9. PMID 21812781 DOI: 10.1111/j.1471-4159.2011.07412.x  0.334
2011 Chong SA, Benilova I, Shaban H, De Strooper B, Devijver H, Moechars D, Eberle W, Bartic C, Van Leuven F, Callewaert G. Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study. Neurobiology of Disease. 44: 284-91. PMID 21807097 DOI: 10.1016/J.Nbd.2011.07.006  0.521
2011 Zhou L, Brouwers N, Benilova I, Vandersteen A, Mercken M, Van Laere K, Van Damme P, Demedts D, Van Leuven F, Sleegers K, Broersen K, Van Broeckhoven C, Vandenberghe R, De Strooper B. Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β'-site increases Aβ generation. Embo Molecular Medicine. 3: 291-302. PMID 21500352 DOI: 10.1002/Emmm.201100138  0.51
2011 Thathiah A, De Strooper B. The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nature Reviews. Neuroscience. 12: 73-87. PMID 21248787 DOI: 10.1038/nrn2977  0.366
2010 Benilova I, De Strooper B. Prion protein in Alzheimer's pathogenesis: a hot and controversial issue. Embo Molecular Medicine. 2: 289-90. PMID 20698011 DOI: 10.1002/emmm.201000088  0.321
2010 De Strooper B. Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process. Physiological Reviews. 90: 465-94. PMID 20393191 DOI: 10.1152/physrev.00023.2009  0.355
2010 Jorissen E, Prox J, Bernreuther C, Weber S, Schwanbeck R, Serneels L, Snellinx A, Craessaerts K, Thathiah A, Tesseur I, Bartsch U, Weskamp G, Blobel CP, Glatzel M, De Strooper B, et al. The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4833-44. PMID 20371803 DOI: 10.1523/Jneurosci.5221-09.2010  0.675
2010 De Strooper B, Vassar R, Golde T. The secretases: enzymes with therapeutic potential in Alzheimer disease. Nature Reviews. Neurology. 6: 99-107. PMID 20139999 DOI: 10.1038/nrneurol.2009.218  0.368
2010 Bergmans BA, De Strooper B. gamma-secretases: from cell biology to therapeutic strategies. The Lancet. Neurology. 9: 215-26. PMID 20129170 DOI: 10.1016/S1474-4422(09)70332-1  0.324
2010 Bergmans BA, Shariati SA, Habets RL, Verstreken P, Schoonjans L, Müller U, Dotti CG, De Strooper B. Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of the amyloid precursor protein in neuronal differentiation. Stem Cells (Dayton, Ohio). 28: 399-406. PMID 20049903 DOI: 10.1002/Stem.296  0.304
2009 Thathiah A, De Strooper B. G protein-coupled receptors, cholinergic dysfunction, and Abeta toxicity in Alzheimer's disease. Science Signaling. 2: re8. PMID 19843960 DOI: 10.1126/scisignal.293re8  0.37
2009 Guix FX, Ill-Raga G, Bravo R, Nakaya T, de Fabritiis G, Coma M, Miscione GP, Villà-Freixa J, Suzuki T, Fernàndez-Busquets X, Valverde MA, de Strooper B, Muñoz FJ. Amyloid-dependent triosephosphate isomerase nitrotyrosination induces glycation and tau fibrillation. Brain : a Journal of Neurology. 132: 1335-45. PMID 19251756 DOI: 10.1093/Brain/Awp023  0.384
2009 Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, Horré K, Vanbrabant M, Coun F, Baekelandt V, Delacourte A, Fischer DF, Pollet D, De Strooper B, Merchiers P. The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science (New York, N.Y.). 323: 946-51. PMID 19213921 DOI: 10.1126/Science.1160649  0.362
2008 O'Connor T, Sadleir KR, Maus E, Velliquette RA, Zhao J, Cole SL, Eimer WA, Hitt B, Bembinster LA, Lammich S, Lichtenthaler SF, Hébert SS, De Strooper B, Haass C, Bennett DA, et al. Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron. 60: 988-1009. PMID 19109907 DOI: 10.1016/J.Neuron.2008.10.047  0.337
2008 Tamboli IY, Prager K, Thal DR, Thelen KM, Dewachter I, Pietrzik CU, St George-Hyslop P, Sisodia SS, De Strooper B, Heneka MT, Filippov MA, Müller U, van Leuven F, Lütjohann D, Walter J. Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12097-106. PMID 19005074 DOI: 10.1523/Jneurosci.2635-08.2008  0.513
2008 Martins IC, Kuperstein I, Wilkinson H, Maes E, Vanbrabant M, Jonckheere W, Van Gelder P, Hartmann D, D'Hooge R, De Strooper B, Schymkowitz J, Rousseau F. Lipids revert inert Abeta amyloid fibrils to neurotoxic protofibrils that affect learning in mice. The Embo Journal. 27: 224-33. PMID 18059472 DOI: 10.1038/Sj.Emboj.7601953  0.322
2007 Imbimbo BP, Del Giudice E, Colavito D, D'Arrigo A, Dalle Carbonare M, Villetti G, Facchinetti F, Volta R, Pietrini V, Baroc MF, Serneels L, De Strooper B, Leon A. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. The Journal of Pharmacology and Experimental Therapeutics. 323: 822-30. PMID 17895400 DOI: 10.1124/jpet.107.129007  0.351
2006 Theuns J, Marjaux E, Vandenbulcke M, Van Laere K, Kumar-Singh S, Bormans G, Brouwers N, Van den Broeck M, Vennekens K, Corsmit E, Cruts M, De Strooper B, Van Broeckhoven C, Vandenberghe R. Alzheimer dementia caused by a novel mutation located in the APP C-terminal intracytosolic fragment. Human Mutation. 27: 888-96. PMID 16917905 DOI: 10.1002/Humu.20402  0.305
2006 Hébert SS, Serneels L, Tolia A, Craessaerts K, Derks C, Filippov MA, Müller U, De Strooper B. Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes. Embo Reports. 7: 739-45. PMID 16729020 DOI: 10.1038/sj.embor.7400704  0.31
2005 Reinhard C, Hébert SS, De Strooper B. The amyloid-beta precursor protein: integrating structure with biological function. The Embo Journal. 24: 3996-4006. PMID 16252002 DOI: 10.1038/sj.emboj.7600860  0.322
2005 Grimm MO, Grimm HS, Pätzold AJ, Zinser EG, Halonen R, Duering M, Tschäpe JA, De Strooper B, Müller U, Shen J, Hartmann T. Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nature Cell Biology. 7: 1118-23. PMID 16227967 DOI: 10.1038/Ncb1313  0.33
2005 Dominguez D, Tournoy J, Hartmann D, Huth T, Cryns K, Deforce S, Serneels L, Camacho IE, Marjaux E, Craessaerts K, Roebroek AJ, Schwake M, D'Hooge R, Bach P, Kalinke U, ... ... De Strooper B, et al. Phenotypic and biochemical analyses of BACE1- and BACE2-deficient mice. The Journal of Biological Chemistry. 280: 30797-806. PMID 15987683 DOI: 10.1074/Jbc.M505249200  0.326
2005 Wong HK, Sakurai T, Oyama F, Kaneko K, Wada K, Miyazaki H, Kurosawa M, De Strooper B, Saftig P, Nukina N. beta Subunits of voltage-gated sodium channels are novel substrates of beta-site amyloid precursor protein-cleaving enzyme (BACE1) and gamma-secretase. The Journal of Biological Chemistry. 280: 23009-17. PMID 15824102 DOI: 10.1074/Jbc.M414648200  0.316
2005 Serneels L, Dejaegere T, Craessaerts K, Horré K, Jorissen E, Tousseyn T, Hébert S, Coolen M, Martens G, Zwijsen A, Annaert W, Hartmann D, De Strooper B. Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 1719-24. PMID 15665098 DOI: 10.1073/Pnas.0408901102  0.313
2004 Dominguez DI, Hartmann D, De Strooper B. BACE1 and presenilin: two unusual aspartyl proteases involved in Alzheimer's disease. Neuro-Degenerative Diseases. 1: 168-74. PMID 16908986 DOI: 10.1159/000080982  0.34
2004 Abad-Rodriguez J, Ledesma MD, Craessaerts K, Perga S, Medina M, Delacourte A, Dingwall C, De Strooper B, Dotti CG. Neuronal membrane cholesterol loss enhances amyloid peptide generation. The Journal of Cell Biology. 167: 953-60. PMID 15583033 DOI: 10.1083/Jcb.200404149  0.313
2004 Camacho IE, Serneels L, Spittaels K, Merchiers P, Dominguez D, De Strooper B. Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10908-17. PMID 15574741 DOI: 10.1523/JNEUROSCI.3987-04.2004  0.321
2003 De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex. Neuron. 38: 9-12. PMID 12691659 DOI: 10.1016/S0896-6273(03)00205-8  0.333
2002 Kumar-Singh S, Julliams A, Nuydens R, Ceuterick C, Labeur C, Serneels S, Vennekens K, Van Osta P, Geerts H, De Strooper B, Van Broeckhoven C. In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity. Neurobiology of Disease. 11: 330-40. PMID 12505425 DOI: 10.1006/nbdi.2002.0529  0.321
2002 Annaert W, De Strooper B. A cell biological perspective on Alzheimer's disease. Annual Review of Cell and Developmental Biology. 18: 25-51. PMID 12142279 DOI: 10.1146/annurev.cellbio.18.020402.142302  0.363
2002 Sai X, Kawamura Y, Kokame K, Yamaguchi H, Shiraishi H, Suzuki R, Suzuki T, Kawaichi M, Miyata T, Kitamura T, De Strooper B, Yanagisawa K, Komano H. Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein. The Journal of Biological Chemistry. 277: 12915-20. PMID 11799129 DOI: 10.1074/Jbc.M112372200  0.352
2001 Cupers P, Orlans I, Craessaerts K, Annaert W, De Strooper B. The amyloid precursor protein (APP)-cytoplasmic fragment generated by gamma-secretase is rapidly degraded but distributes partially in a nuclear fraction of neurones in culture. Journal of Neurochemistry. 78: 1168-78. PMID 11553691  0.347
2001 Wiltfang J, Esselmann H, Cupers P, Neumann M, Kretzschmar H, Beyermann M, Schleuder D, Jahn H, Rüther E, Kornhuber J, Annaert W, De Strooper B, Saftig P. Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells. The Journal of Biological Chemistry. 276: 42645-57. PMID 11526104 DOI: 10.1074/Jbc.M102790200  0.33
2001 De Jonghe C, Esselens C, Kumar-Singh S, Craessaerts K, Serneels S, Checler F, Annaert W, Van Broeckhoven C, De Strooper B. Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability. Human Molecular Genetics. 10: 1665-71. PMID 11487570 DOI: 10.1093/Hmg/10.16.1665  0.312
2001 Dominguez DI, De Strooper B, Annaert W. Secretases as therapeutic targets for the treatment of Alzheimer's disease. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 124-42. PMID 11409035 DOI: 10.3109/13506120109007356  0.339
2001 Creemers JW, Ines Dominguez D, Plets E, Serneels L, Taylor NA, Multhaup G, Craessaerts K, Annaert W, De Strooper B. Processing of beta-secretase by furin and other members of the proprotein convertase family. The Journal of Biological Chemistry. 276: 4211-7. PMID 11071887 DOI: 10.1074/Jbc.M006947200  0.341
2000 Ledesma MD, Da Silva JS, Crassaerts K, Delacourte A, De Strooper B, Dotti CG. Brain plasmin enhances APP alpha-cleavage and Abeta degradation and is reduced in Alzheimer's disease brains. Embo Reports. 1: 530-5. PMID 11263499 DOI: 10.1093/Embo-Reports/Kvd107  0.38
2000 Annaert W, Cupers P, Saftig P, De Strooper B. Presenilin function in APP processing. Annals of the New York Academy of Sciences. 920: 158-64. PMID 11193144 DOI: 10.1111/J.1749-6632.2000.Tb06917.X  0.379
2000 Annaert W, De Strooper B. Neuronal models to study amyloid precursor protein expression and processing in vitro. Biochimica Et Biophysica Acta. 1502: 53-62. PMID 10899431 DOI: 10.1016/S0925-4439(00)00032-6  0.388
2000 De Strooper B, Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. Journal of Cell Science. 113: 1857-70. PMID 10806097  0.341
1999 Saftig P, Hartmann D, De Strooper B. The function of presenilin-1 in amyloid beta-peptide generation and brain development. European Archives of Psychiatry and Clinical Neuroscience. 249: 271-9. PMID 10653282 DOI: 10.1007/S004060050099  0.347
1999 Haass C, De Strooper B. The presenilins in Alzheimer's disease--proteolysis holds the key. Science (New York, N.Y.). 286: 916-9. PMID 10542139 DOI: 10.1126/Science.286.5441.916  0.41
1999 Annaert WG, Levesque L, Craessaerts K, Dierinck I, Snellings G, Westaway D, George-Hyslop PS, Cordell B, Fraser P, De Strooper B. Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons. The Journal of Cell Biology. 147: 277-94. PMID 10525535 DOI: 10.1083/Jcb.147.2.277  0.322
1999 Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, ... ... De Strooper B, et al. Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proceedings of the National Academy of Sciences of the United States of America. 96: 11872-7. PMID 10518543 DOI: 10.1073/Pnas.96.21.11872  0.505
1999 Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1. Molecular Medicine (Cambridge, Mass.). 5: 542-54. PMID 10501657 DOI: 10.1007/Bf03401981  0.532
1998 Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F. Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder. Behavioural Brain Research. 95: 55-64. PMID 9754877 DOI: 10.1016/S0166-4328(97)00210-6  0.553
1998 Simons M, Keller P, De Strooper B, Beyreuther K, Dotti CG, Simons K. Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95: 6460-4. PMID 9600988 DOI: 10.1073/Pnas.95.11.6460  0.332
1998 De Strooper B, Saftig P, Craessaerts K, Vanderstichele H, Guhde G, Annaert W, Von Figura K, Van Leuven F. Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein. Nature. 391: 387-90. PMID 9450754 DOI: 10.1038/34910  0.576
1997 De Strooper B, Beullens M, Contreras B, Levesque L, Craessaerts K, Cordell B, Moechars D, Bollen M, Fraser P, George-Hyslop PS, Van Leuven F. Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins. The Journal of Biological Chemistry. 272: 3590-8. PMID 9013610 DOI: 10.1074/Jbc.272.6.3590  0.525
1996 Tienari PJ, De Strooper B, Ikonen E, Ida N, Simons M, Masters CL, Dotti CG, Beyreuther K. Neuronal sorting and processing of amyloid precursor protein: implications for Alzheimer's disease. Cold Spring Harbor Symposia On Quantitative Biology. 61: 575-85. PMID 9246484 DOI: 10.1101/Sqb.1996.061.01.058  0.325
1996 De Strooper B, Wu RR, Jaspers M, Van der Schueren B, Vekemans S, Carmeliet G, Van Leuven F, Van Den Oord J, Cassiman JJ. A 68-kD antigen, which is probably an N-terminal fragment of the VLA-5 alpha 5-subunit, is specific for differentiating keratinocytes. Dermatology (Basel, Switzerland). 193: 212-20. PMID 8944343  0.467
1996 Saftig P, Peters C, von Figura K, Craessaerts K, Van Leuven F, De Strooper B. Amyloidogenic processing of human amyloid precursor protein in hippocampal neurons devoid of cathepsin D. The Journal of Biological Chemistry. 271: 27241-4. PMID 8910296 DOI: 10.1074/jbc.271.44.27241  0.575
1996 Tienari PJ, De Strooper B, Ikonen E, Simons M, Weidemann A, Czech C, Hartmann T, Ida N, Multhaup G, Masters CL, Van Leuven F, Beyreuther K, Dotti CG. The beta-amyloid domain is essential for axonal sorting of amyloid precursor protein. The Embo Journal. 15: 5218-29. PMID 8895567  0.497
1996 Moechars D, Lorent K, De Strooper B, Dewachter I, Van Leuven F. Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice. The Embo Journal. 15: 1265-74. PMID 8635459  0.532
1995 De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 270: 30310-4. PMID 8530453  0.532
1995 De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease. The Journal of Biological Chemistry. 270: 4058-65. PMID 7876155  0.56
1995 De Strooper B, Creemers JW, Moechars D, Huylebroeck D, Van De Ven WJ, Van Leuven F, Van den Berghe H. Amyloid precursor protein is not processed by furin, PACE 4, PC1/3, PC2, PC4 and PC5/6 of the furin family of proprotein processing enzymes. Biochimica Et Biophysica Acta. 1246: 185-8. PMID 7819286  0.535
1995 Van Leuven F, Hilliker C, Serneels L, Umans L, Overbergh L, De Strooper B, Fryns JP, Van den Berghe H. Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein. Genomics. 25: 492-500. PMID 7789983  0.434
1995 Van Gool D, De Strooper B, Van Leuven F, Dom R. Amyloid precursor protein accumulation in Lewy body dementia and Alzheimer's disease. Dementia (Basel, Switzerland). 6: 63-8. PMID 7606281  0.577
1995 De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence. The Embo Journal. 14: 4932-8. PMID 7588622 DOI: 10.1002/J.1460-2075.1995.Tb00176.X  0.588
1995 Lorent K, Overbergh L, Moechars D, De Strooper B, Van Leuven F, Van den Berghe H. Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein. Neuroscience. 65: 1009-25. PMID 7542371  0.518
1994 Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B. Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein. Genomics. 24: 78-89. PMID 7534747  0.452
1994 Umans L, Serneels L, Hilliker C, Stas L, Overbergh L, De Strooper B, Van Leuven F, Van den Berghe H. Molecular cloning of the mouse gene coding for alpha 2-macroglobulin and targeting of the gene in embryonic stem cells. Genomics. 22: 519-29. PMID 7528166 DOI: 10.1006/geno.1994.1425  0.426
1993 Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S. Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA. Biochimica Et Biophysica Acta. 1173: 71-4. PMID 8485155  0.459
1993 De Strooper B, Umans L, Van Leuven F, Van Den Berghe H. Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway. The Journal of Cell Biology. 121: 295-304. PMID 8468348  0.572
1993 Van Gool D, De Strooper B, Van Leuven F, Triau E, Dom R. alpha 2-Macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease. Neurobiology of Aging. 14: 233-7. PMID 7686641  0.521
1993 De Strooper B, Van Leuven F. Alpha 2-macroglobulin and subacute-phase responses in Alzheimer's disease. Immunology Today. 14: 143-4. PMID 7682079  0.469
1993 Jaspers M, Vekemans S, Carmeliet G, van Leuven F, de Strooper B, Deckmyn H, Cassiman JJ. A monoclonal antibody to the alpha 2 integrin subunit cross-reacts with RGD-dependent epitopes in fibrinogen. Hybridoma. 12: 467-74. PMID 7503943  0.437
1992 Delabie J, Shipman R, Brüggen J, De Strooper B, van Leuven F, Tarcsay L, Cerletti N, Odink K, Diehl V, Bilbe G. Expression of the novel intermediate filament-associated protein restin in Hodgkin's disease and anaplastic large-cell lymphoma. Blood. 80: 2891-6. PMID 1450414  0.459
1992 De Strooper B, Van Leuven F, Van den Berghe H. Alpha 2-macroglobulin and other proteinase inhibitors do not interfere with the secretion of amyloid precursor protein in mouse neuroblastoma cells. Febs Letters. 308: 50-3. PMID 1379551  0.539
1992 van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H. The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA. European Journal of Biochemistry / Febs. 210: 319-27. PMID 1280217  0.442
1991 De Strooper B, Van Leuven F, Carmeliet G, Van Den Berghe H, Cassiman JJ. Cultured human fibroblasts contain a large pool of precursor beta 1-integrin but lack an intracellular pool of mature subunit. European Journal of Biochemistry / Febs. 199: 25-33. PMID 1906002  0.468
1991 De Strooper B, Van Leuven F, Van den Berghe H. The amyloid beta protein precursor or proteinase nexin II from mouse is closer related to its human homolog than previously reported. Biochimica Et Biophysica Acta. 1129: 141-3. PMID 1756177  0.519
1989 De Strooper B, Van der Schueren B, Jaspers M, Saison M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Distribution of the beta 1 subgroup of the integrins in human cells and tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 37: 299-307. PMID 2645360  0.445
1988 De Strooper B, Saison M, Jaspers M, Spaepen M, Van Leuven F, Van den Berghe H, Cassiman JJ. Monoclonal antibody DH12 reacts with a cell surface and a precursor form of the beta subunit of the human fibronectin receptor. Cell Biology International Reports. 12: 9-16. PMID 2969294  0.469
1988 Jaspers M, de Strooper B, Spaepen M, van Leuven F, David G, van den Berghe H, Cassiman JJ. Post-translational modification of the beta-subunit of the human fibronectin receptor. Febs Letters. 231: 402-6. PMID 2966078 DOI: 10.1016/0014-5793(88)80859-7  0.473
1988 Zhang Y, Saison M, Spaepen M, De Strooper B, Van Leuven F, David G, Van den Berghe H, Cassiman JJ. Mapping of human fibronectin receptor beta subunit gene to chromosome 10. Somatic Cell and Molecular Genetics. 14: 99-104. PMID 2963381  0.463
Low-probability matches (unlikely to be authored by this person)
2011 Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nature Reviews. Drug Discovery. 10: 698-712. PMID 21852788 DOI: 10.1038/nrd3505  0.3
2008 Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proceedings of the National Academy of Sciences of the United States of America. 105: 6415-20. PMID 18434550 DOI: 10.1073/Pnas.0710263105  0.299
2010 Annaert W, De Strooper B. Alzheimer's disease neurons fail the acid test. Cell. 141: 1112-4. PMID 20602994 DOI: 10.1016/J.Cell.2010.06.009  0.299
2016 Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B. Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds. Neuron. 90: 410-6. PMID 27100199 DOI: 10.1016/j.neuron.2016.03.010  0.298
2016 Ungureanu AA, Benilova I, Krylychkina O, Braeken D, De Strooper B, Van Haesendonck C, Dotti CG, Bartic C. Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons. Scientific Reports. 6: 25841. PMID 27173984 DOI: 10.1038/Srep25841  0.297
2021 McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nature Reviews. Neurology. PMID 34548654 DOI: 10.1038/s41582-021-00545-1  0.296
2019 Poppe L, Rué L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, Courtand G, de Boer A, Smolders S, Van Damme P, Van Den Bosch L, D'Hooge R, De Strooper B, Robberecht W, Lemmens R. EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease. Alzheimer's Research & Therapy. 11: 102. PMID 31831046 DOI: 10.1186/s13195-019-0554-4  0.295
2003 Lichtenthaler SF, Dominguez DI, Westmeyer GG, Reiss K, Haass C, Saftig P, De Strooper B, Seed B. The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. The Journal of Biological Chemistry. 278: 48713-9. PMID 14507929 DOI: 10.1074/Jbc.M303861200  0.294
2009 Dotti CG, De Strooper B. Alzheimer's dementia by circulation disorders: when trees hide the forest. Nature Cell Biology. 11: 114-6. PMID 19188916 DOI: 10.1038/Ncb0209-114  0.293
2002 Dominguez DI, De Strooper B. Novel therapeutic strategies provide the real test for the amyloid hypothesis of Alzheimer's disease. Trends in Pharmacological Sciences. 23: 324-30. PMID 12119153  0.291
2017 Le Guennec K, Veugelen S, Quenez O, Szaruga M, Rousseau S, Nicolas G, Wallon D, Fluchere F, Frébourg T, De Strooper B, Campion D, Chávez-Gutiérrez L, Rovelet-Lecrux A. Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds. Neurobiology of Disease. PMID 28461250 DOI: 10.1016/J.Nbd.2017.04.020  0.291
1998 Saftig P, de Strooper B. Downregulation of PS1 expression in neurons decreases beta-amyloid production: a biochemical link between the two major familial Alzheimer's disease genes. Molecular Psychiatry. 3: 287-9. PMID 9702732  0.291
2021 Scheltens P, De Strooper B, Kivipelto M, Holstege H, Chételat G, Teunissen CE, Cummings J, van der Flier WM. Alzheimer's disease. Lancet (London, England). PMID 33667416 DOI: 10.1016/S0140-6736(20)32205-4  0.291
2009 Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, ... ... De Strooper B, et al. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (New York, N.Y.). 324: 639-42. PMID 19299585 DOI: 10.1126/Science.1171176  0.29
2020 Serneels L, T'Syen D, Perez-Benito L, Theys T, Holt MG, De Strooper B. Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease. Molecular Neurodegeneration. 15: 60. PMID 33076948 DOI: 10.1186/s13024-020-00399-z  0.29
2019 Mancuso R, Van Den Daele J, Fattorelli N, Wolfs L, Balusu S, Burton O, Liston A, Sierksma A, Fourne Y, Poovathingal S, Arranz-Mendiguren A, Sala Frigerio C, Claes C, Serneels L, Theys T, ... ... De Strooper B, et al. Stem-cell-derived human microglia transplanted in mouse brain to study human disease. Nature Neuroscience. PMID 31659342 DOI: 10.1038/S41593-019-0525-X  0.289
2004 Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, Saftig P, Craessaerts K, De Strooper B, Hartmann D. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Human Molecular Genetics. 13: 1321-31. PMID 15128703 DOI: 10.1093/Hmg/Ddh151  0.289
2018 García-León JA, Cabrera-Socorro A, Eggermont K, Swijsen A, Terryn J, Fazal R, Nami F, Ordovás L, Quiles A, Lluis F, Serneels L, Wierda K, Sierksma A, Kreir M, Pestana F, ... ... De Strooper B, et al. Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein tau mutations which displays several phenotypes linked to neurodegeneration. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30036493 DOI: 10.1016/J.Jalz.2018.05.007  0.288
2015 Sala Frigerio C, Lau P, Troakes C, Deramecourt V, Gele P, Van Loo P, Voet T, De Strooper B. On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 25937274 DOI: 10.1016/j.jalz.2015.02.007  0.287
2023 Balusu S, Horré K, Thrupp N, Craessaerts K, Snellinx A, Serneels L, T'Syen D, Chrysidou I, Arranz AM, Sierksma A, Simrén J, Karikari TK, Zetterberg H, Chen WT, Thal DR, ... ... De Strooper B, et al. MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease. Science (New York, N.Y.). 381: 1176-1182. PMID 37708272 DOI: 10.1126/science.abp9556  0.287
2006 Bentahir M, Nyabi O, Verhamme J, Tolia A, Horré K, Wiltfang J, Esselmann H, De Strooper B. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. Journal of Neurochemistry. 96: 732-42. PMID 16405513 DOI: 10.1111/J.1471-4159.2005.03578.X  0.286
2012 Benilova I, Karran E, De Strooper B. The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes. Nature Neuroscience. 15: 349-57. PMID 22286176 DOI: 10.1038/nn.3028  0.286
2001 Tomita T, Watabiki T, Takikawa R, Morohashi Y, Takasugi N, Kopan R, De Strooper B, Iwatsubo T. The first proline of PALP motif at the C terminus of presenilins is obligatory for stabilization, complex formation, and gamma-secretase activities of presenilins. The Journal of Biological Chemistry. 276: 33273-81. PMID 11432849 DOI: 10.1074/jbc.M011152200  0.285
2022 Shah D, Gsell W, Wahis J, Luckett ES, Jamoulle T, Vermaercke B, Preman P, Moechars D, Hendrickx V, Jaspers T, Craessaerts K, Horré K, Wolfs L, Fiers M, Holt M, ... ... De Strooper B, et al. Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease. Cell Reports. 40: 111280. PMID 36001964 DOI: 10.1016/j.celrep.2022.111280  0.285
2018 Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG. High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease. Neurobiology of Disease. PMID 29427755 DOI: 10.1016/J.Nbd.2018.02.001  0.285
2021 Liu T, Zhang T, Nicolas M, Boussicault L, Rice H, Soldano A, Claeys A, Petrova I, Fradkin L, De Strooper B, Potier MC, Hassan BA. The amyloid precursor protein is a conserved Wnt receptor. Elife. 10. PMID 34515635 DOI: 10.7554/eLife.69199  0.284
2020 Lauwers E, Lalli G, Brandner S, Collinge J, Compernolle V, Duyckaerts C, Edgren G, Haïk S, Hardy J, Helmy A, Ivinson AJ, Jaunmuktane Z, Jucker M, Knight R, Lemmens R, ... ... De Strooper B, et al. Potential human transmission of amyloid β pathology: surveillance and risks. The Lancet. Neurology. 19: 872-878. PMID 32949547 DOI: 10.1016/S1474-4422(20)30238-6  0.283
2021 Preman P, Tcw J, Calafate S, Snellinx A, Alfonso-Triguero M, Corthout N, Munck S, Thal DR, Goate AM, De Strooper B, Arranz AM. Human iPSC-derived astrocytes transplanted into the mouse brain undergo morphological changes in response to amyloid-β plaques. Molecular Neurodegeneration. 16: 68. PMID 34563212 DOI: 10.1186/s13024-021-00487-8  0.283
2017 Hernandez AL, Shah D, Craessaerts K, Saido T, Saito T, De Strooper B, Van der Linden A, D'Hooge R. Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP(NL-G-F) mice before prominent plaque deposition. Behavioural Brain Research. PMID 29158112 DOI: 10.1016/j.bbr.2017.11.017  0.282
2022 Stevenson-Hoare J, Heslegrave A, Leonenko G, Fathalla D, Bellou E, Luckcuck L, Marshall R, Sims R, Morgan BP, Hardy J, de Strooper B, Williams J, Zetterberg H, Escott-Price V. Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease. Brain : a Journal of Neurology. PMID 35383826 DOI: 10.1093/brain/awac128  0.282
2009 Wakabayashi T, Craessaerts K, Bammens L, Bentahir M, Borgions F, Herdewijn P, Staes A, Timmerman E, Vandekerckhove J, Rubinstein E, Boucheix C, Gevaert K, De Strooper B. Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nature Cell Biology. 11: 1340-6. PMID 19838174 DOI: 10.1038/Ncb1978  0.282
2001 Sisodia SS, Annaert W, Kim SH, De Strooper B. Gamma-secretase: never more enigmatic. Trends in Neurosciences. 24: S2-6. PMID 11881741 DOI: 10.1016/S0166-2236(00)01987-1  0.281
2007 De Strooper B. Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. Embo Reports. 8: 141-6. PMID 17268505 DOI: 10.1038/sj.embor.7400897  0.281
2010 Espuny-Camacho I, Dominguez D, Merchiers P, Van Rompaey L, Selkoe D, De Strooper B. Peroxisome proliferator-activated receptor gamma enhances the activity of an insulin degrading enzyme-like metalloprotease for amyloid-beta clearance. Journal of Alzheimer's Disease : Jad. 20: 1119-32. PMID 20413872 DOI: 10.3233/JAD-2010-091633  0.28
2000 Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C. Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease. Human Molecular Genetics. 9: 2589-98. PMID 11063718  0.28
2005 Leyssen M, Ayaz D, Hébert SS, Reeve S, De Strooper B, Hassan BA. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. The Embo Journal. 24: 2944-55. PMID 16052209 DOI: 10.1038/sj.emboj.7600757  0.28
2003 Kahle PJ, De Strooper B. Attack on amyloid. Embo Reports. 4: 747-51. PMID 12897797 DOI: 10.1038/sj.embor.embor905  0.28
2021 Lalli G, Schott JM, Hardy J, De Strooper B. Aducanumab: a new phase in therapeutic development for Alzheimer's disease? Embo Molecular Medicine. e14781. PMID 34338436 DOI: 10.15252/emmm.202114781  0.279
2014 De Strooper B. Lessons from a failed γ-secretase Alzheimer trial. Cell. 159: 721-6. PMID 25417150 DOI: 10.1016/j.cell.2014.10.016  0.279
1999 De Strooper B, Annaert W, Cupers P, Saftig P, Craessaerts K, Mumm JS, Schroeter EH, Schrijvers V, Wolfe MS, Ray WJ, Goate A, Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature. 398: 518-22. PMID 10206645 DOI: 10.1038/19083  0.279
2022 Marino M, Zhou L, Rincon MY, Callaerts-Vegh Z, Verhaert J, Wahis J, Creemers E, Yshii L, Wierda K, Saito T, Marneffe C, Voytyuk I, Wouters Y, Dewilde M, Duqué SI, ... ... De Strooper B, et al. AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model. Embo Molecular Medicine. 14: e09824. PMID 35352880 DOI: 10.15252/emmm.201809824  0.279
2004 Dejaegere T, de Strooper B. [Secretases as therapeutic targets for the treatment of Alzheimer's disease]. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgiã«. 66: 29-58; discussion 58. PMID 15074081  0.278
2021 Guerrero A, De Strooper B, Arancibia-Cárcamo IL. Cellular senescence at the crossroads of inflammation and Alzheimer's disease. Trends in Neurosciences. 44: 714-727. PMID 34366147 DOI: 10.1016/j.tins.2021.06.007  0.276
2018 Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, ... ... de Strooper B, et al. Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP. Brain : a Journal of Neurology. PMID 29945247 DOI: 10.1093/Brain/Awy159  0.275
2002 Flood DG, Reaume AG, Dorfman KS, Lin YG, Lang DM, Trusko SP, Savage MJ, Annaert WG, De Strooper B, Siman R, Scott RW. FAD mutant PS-1 gene-targeted mice: increased A beta 42 and A beta deposition without APP overproduction. Neurobiology of Aging. 23: 335-48. PMID 11959395 DOI: 10.1016/S0197-4580(01)00330-X  0.274
2014 Acx H, Chávez-Gutiérrez L, Serneels L, Lismont S, Benurwar M, Elad N, De Strooper B. Signature amyloid β profiles are produced by different γ-secretase complexes. The Journal of Biological Chemistry. 289: 4346-55. PMID 24338474 DOI: 10.1074/jbc.M113.530907  0.272
2008 Wakabayashi T, De Strooper B. Presenilins: members of the gamma-secretase quartets, but part-time soloists too. Physiology (Bethesda, Md.). 23: 194-204. PMID 18697993 DOI: 10.1152/physiol.00009.2008  0.272
2012 Brouillette J, Caillierez R, Zommer N, Alves-Pires C, Benilova I, Blum D, De Strooper B, Buée L. Neurotoxicity and memory deficits induced by soluble low-molecular-weight amyloid-β1-42 oligomers are revealed in vivo by using a novel animal model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7852-61. PMID 22674261 DOI: 10.1523/Jneurosci.5901-11.2012  0.272
2016 Sala Frigerio C, De Strooper B. Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics. Annual Review of Neuroscience. PMID 27050320 DOI: 10.1146/annurev-neuro-070815-014015  0.272
2009 Huysseune S, Kienlen-Campard P, Hébert S, Tasiaux B, Leroy K, Devuyst O, Brion JP, De Strooper B, Octave JN. Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 4158-67. PMID 19687153 DOI: 10.1096/fj.09-140012  0.272
1996 Simons M, de Strooper B, Multhaup G, Tienari PJ, Dotti CG, Beyreuther K. Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 899-908. PMID 8558258 DOI: 10.1523/Jneurosci.16-03-00899.1996  0.272
2013 Prox J, Bernreuther C, Altmeppen H, Grendel J, Glatzel M, D'Hooge R, Stroobants S, Ahmed T, Balschun D, Willem M, Lammich S, Isbrandt D, Schweizer M, Horré K, De Strooper B, et al. Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 12915-28, 12928a. PMID 23926248 DOI: 10.1523/Jneurosci.5910-12.2013  0.271
1999 Hartmann D, De Strooper B, Saftig P. Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly. Current Biology : Cb. 9: 719-27. PMID 10421573 DOI: 10.1016/S0960-9822(99)80331-5  0.271
2020 Enzlein T, Cordes J, Munteanu B, Michno W, Serneels L, De Strooper B, Hanrieder J, Wolf I, Chávez-Gutiérrez L, Hopf C. Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images. Analytical Chemistry. 92: 14484-14493. PMID 33138378 DOI: 10.1021/acs.analchem.0c02585  0.269
2018 Voytyuk I, Mueller SA, Herber J, Snellinx A, Moechars D, van Loo G, Lichtenthaler SF, De Strooper B. BACE2 distribution in major brain cell types and identification of novel substrates. Life Science Alliance. 1: e201800026. PMID 30456346 DOI: 10.26508/lsa.201800026  0.268
2004 Marjaux E, Hartmann D, De Strooper B. Presenilins in memory, Alzheimer's disease, and therapy. Neuron. 42: 189-92. PMID 15091335 DOI: 10.1016/S0896-6273(04)00218-1  0.268
2010 De Strooper B. The molecular study of Alzheimer's disease: The road to a causal treatment | De moleculaire studie van de ziekte van Alzheimer: Op weg naar een causale behandeling Tijdschrift Voor Geneeskunde. 66: 1150-1155. DOI: 10.2143/TVG.66.23.2000874  0.266
2014 Finoulst M, Vankrunkelsven P, De Strooper B, De Lepeleire J. Does it make sense for the early detection of Alzheimer's disease? | Heeft het zin om de ziekte van Alzheimer vroegtijdig op te sporen? Tijdschrift Voor Geneeskunde. 70: 917-919. DOI: 10.2143/TVG.70.00.2001671  0.265
2011 Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimer's Research & Therapy. 3: 1. PMID 21211070 DOI: 10.1186/Alzrt59  0.264
2013 Soldano A, Okray Z, Janovska P, Tmejová K, Reynaud E, Claeys A, Yan J, Atak ZK, De Strooper B, Dura JM, Bryja V, Hassan BA. The Drosophila homologue of the amyloid precursor protein is a conserved modulator of Wnt PCP signaling. Plos Biology. 11: e1001562. PMID 23690751 DOI: 10.1371/journal.pbio.1001562  0.264
1999 Annaert W, De Strooper B. Presenilins: molecular switches between proteolysis and signal transduction. Trends in Neurosciences. 22: 439-43. PMID 10481190 DOI: 10.1016/S0166-2236(99)01455-1  0.263
2003 Schroeter EH, Ilagan MX, Brunkan AL, Hecimovic S, Li YM, Xu M, Lewis HD, Saxena MT, De Strooper B, Coonrod A, Tomita T, Iwatsubo T, Moore CL, Goate A, Wolfe MS, et al. A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 100: 13075-80. PMID 14566063 DOI: 10.1073/Pnas.1735338100  0.262
2021 Walgrave H, Balusu S, Snoeck S, Vanden Eynden E, Craessaerts K, Thrupp N, Wolfs L, Horré K, Fourne Y, Ronisz A, Silajdžić E, Penning A, Tosoni G, Callaerts-Vegh Z, D'Hooge R, ... ... De Strooper B, et al. Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease. Cell Stem Cell. PMID 34033742 DOI: 10.1016/j.stem.2021.05.001  0.262
2013 Shariati SA, De Strooper B. Redundancy and divergence in the amyloid precursor protein family. Febs Letters. 587: 2036-45. PMID 23707420 DOI: 10.1016/j.febslet.2013.05.026  0.261
2017 Hardy J, De Strooper B. Alzheimer's disease: where next for anti-amyloid therapies? Brain : a Journal of Neurology. 140: 853-855. PMID 28375461 DOI: 10.1093/Brain/Awx059  0.261
2010 Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, ... ... De Strooper B, et al. Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. The Embo Journal. 29: 3408-20. PMID 20818335 DOI: 10.1038/Emboj.2010.211  0.259
2004 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T. Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. The Journal of Biological Chemistry. 279: 24343-54. PMID 15037614 DOI: 10.1074/Jbc.M401925200  0.259
2000 De Strooper B. Alzheimer's disease. Closing in on gamma-secretase. Nature. 405: 627, 629. PMID 10864307 DOI: 10.1038/35015193  0.258
2003 Herreman A, Van Gassen G, Bentahir M, Nyabi O, Craessaerts K, Mueller U, Annaert W, De Strooper B. gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation. Journal of Cell Science. 116: 1127-36. PMID 12584255 DOI: 10.1242/Jcs.00292  0.255
2020 Cerofolini L, Ravera E, Bologna S, Wiglenda T, Böddrich A, Purfürst B, Benilova I, Korsak M, Gallo G, Rizzo D, Gonnelli L, Fragai M, De Strooper B, Wanker EE, Luchinat C. Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils. Chemical Communications (Cambridge, England). 56: 8830-8833. PMID 32749391 DOI: 10.1039/d0cc02463e  0.253
2012 Chávez-Gutiérrez L, Bammens L, Benilova I, Vandersteen A, Benurwar M, Borgers M, Lismont S, Zhou L, Van Cleynenbreugel S, Esselmann H, Wiltfang J, Serneels L, Karran E, Gijsen H, Schymkowitz J, ... ... De Strooper B, et al. The mechanism of γ-Secretase dysfunction in familial Alzheimer disease. The Embo Journal. 31: 2261-74. PMID 22505025 DOI: 10.1038/emboj.2012.79  0.253
2016 Salta E, Sierksma A, Vanden Eynden E, De Strooper B. miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain. Embo Molecular Medicine. PMID 27485122 DOI: 10.15252/emmm.201606520  0.253
2010 Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 8566-80. PMID 20573903 DOI: 10.1523/Jneurosci.1554-10.2010  0.252
2004 Wilquet V, De Strooper B. Amyloid-beta precursor protein processing in neurodegeneration. Current Opinion in Neurobiology. 14: 582-8. PMID 15464891 DOI: 10.1016/j.conb.2004.08.001  0.252
2015 Ryan NS, Biessels GJ, Kim L, Nicholas JM, Barber PA, Walsh P, Gami P, Morris HR, Bastos-Leite AJ, Schott JM, Beck J, Mead S, Chavez-Gutierrez L, de Strooper B, Rossor MN, et al. Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer's disease. Neurobiology of Aging. PMID 26410308 DOI: 10.1016/J.Neurobiolaging.2015.08.026  0.25
2003 De Strooper B, Woodgett J. Alzheimer's disease: Mental plaque removal. Nature. 423: 392-3. PMID 12761533 DOI: 10.1038/423392A  0.249
2020 Sierksma A, Escott-Price V, De Strooper B. Translating genetic risk of Alzheimer's disease into mechanistic insight and drug targets. Science (New York, N.Y.). 370: 61-66. PMID 33004512 DOI: 10.1126/science.abb8575  0.249
2018 Sierksma A, Lu A, Salta E, Vanden Eynden E, Callaerts-Vegh Z, D'Hooge R, Blum D, Buée L, Fiers M, De Strooper B. Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology. Molecular Neurodegeneration. 13: 54. PMID 30314521 DOI: 10.1186/S13024-018-0285-1  0.249
2010 De Strooper B, Annaert W. Novel research horizons for presenilins and γ-secretases in cell biology and disease. Annual Review of Cell and Developmental Biology. 26: 235-60. PMID 20604710 DOI: 10.1146/Annurev-Cellbio-100109-104117  0.249
2001 Hartmann D, Tournoy J, Saftig P, Annaert W, De Strooper B. Implication of APP secretases in notch signaling. Journal of Molecular Neuroscience : Mn. 17: 171-81. PMID 11816790 DOI: 10.1385/Jmn:17:2:171  0.248
2006 Avila J, Nitsch RM, Haass C, De Strooper B. European Alzheimer disease funding. Nature Medicine. 12: 776-7. PMID 16829945 DOI: 10.1038/nm0706-776  0.248
2011 Altmeppen HC, Prox J, Puig B, Kluth MA, Bernreuther C, Thurm D, Jorissen E, Petrowitz B, Bartsch U, De Strooper B, Saftig P, Glatzel M. Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo. Molecular Neurodegeneration. 6: 36. PMID 21619641 DOI: 10.1186/1750-1326-6-36  0.248
2007 Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS. Active gamma-secretase complexes contain only one of each component. The Journal of Biological Chemistry. 282: 33985-93. PMID 17911105 DOI: 10.1074/Jbc.M705248200  0.248
1998 Zhang Z, Hartmann H, Do VM, Abramowski D, Sturchler-Pierrat C, Staufenbiel M, Sommer B, van de Wetering M, Clevers H, Saftig P, De Strooper B, He X, Yankner BA. Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 395: 698-702. PMID 9790190 DOI: 10.1038/27208  0.247
2010 Lau P, de Strooper B. Dysregulated microRNAs in neurodegenerative disorders. Seminars in Cell & Developmental Biology. 21: 768-73. PMID 20080199 DOI: 10.1016/j.semcdb.2010.01.009  0.247
2012 De Strooper B, Scorrano L. Close encounter: mitochondria, endoplasmic reticulum and Alzheimer's disease. The Embo Journal. 31: 4095-7. PMID 23047154 DOI: 10.1038/emboj.2012.279  0.247
2013 Reinhard C, Borgers M, David G, De Strooper B. Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans. Journal of Cell Science. 126: 4856-61. PMID 23986479 DOI: 10.1242/jcs.137919  0.247
2001 Cupers P, Bentahir M, Craessaerts K, Orlans I, Vanderstichele H, Saftig P, De Strooper B, Annaert W. The discrepancy between presenilin subcellular localization and gamma-secretase processing of amyloid precursor protein. The Journal of Cell Biology. 154: 731-40. PMID 11502763 DOI: 10.1083/jcb.200104045  0.246
2005 Nakaya Y, Yamane T, Shiraishi H, Wang HQ, Matsubara E, Sato T, Dolios G, Wang R, De Strooper B, Shoji M, Komano H, Yanagisawa K, Ihara Y, Fraser P, St George-Hyslop P, et al. Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. The Journal of Biological Chemistry. 280: 19070-7. PMID 15764596 DOI: 10.1074/jbc.M501130200  0.246
2003 Nyabi O, Bentahir M, Horré K, Herreman A, Gottardi-Littell N, Van Broeckhoven C, Merchiers P, Spittaels K, Annaert W, De Strooper B. Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin. The Journal of Biological Chemistry. 278: 43430-6. PMID 12885769 DOI: 10.1074/Jbc.M306957200  0.245
2004 Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. The Journal of Cell Biology. 166: 1041-54. PMID 15452145 DOI: 10.1083/Jcb.200406060  0.244
2015 Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, et al. Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome. Neuron. 87: 382-98. PMID 26182420 DOI: 10.1016/J.Neuron.2015.06.032  0.243
2009 Tousseyn T, Thathiah A, Jorissen E, Raemaekers T, Konietzko U, Reiss K, Maes E, Snellinx A, Serneels L, Nyabi O, Annaert W, Saftig P, Hartmann D, De Strooper B. ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase. The Journal of Biological Chemistry. 284: 11738-47. PMID 19213735 DOI: 10.1074/Jbc.M805894200  0.242
2007 De Strooper B. Alzheimer research forum discussion: Gain or loss of function - Time to shake up assumptions on γ-secretase in Alzheimer disease? Commentary Journal of Alzheimer's Disease. 11: 403-405.  0.242
2011 Brodaty H, Breteler MM, Dekosky ST, Dorenlot P, Fratiglioni L, Hock C, Kenigsberg PA, Scheltens P, De Strooper B. The world of dementia beyond 2020. Journal of the American Geriatrics Society. 59: 923-7. PMID 21488846 DOI: 10.1111/J.1532-5415.2011.03365.X  0.241
2019 Arranz AM, De Strooper B. The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications. The Lancet. Neurology. PMID 30795987 DOI: 10.1016/S1474-4422(18)30490-3  0.24
2019 Rice HC, de Malmazet D, Schreurs A, Frere S, Van Molle I, Volkov AN, Creemers E, Vertkin I, Nys J, Ranaivoson FM, Comoletti D, Savas JN, Remaut H, Balschun D, Wierda KD, ... ... De Strooper B, et al. Secreted amyloid-β precursor protein functions as a GABAR1a ligand to modulate synaptic transmission. Science (New York, N.Y.). 363. PMID 30630900 DOI: 10.1126/Science.Aao4827  0.24
2020 Arranz AM, Preman P, T.C.W. J, Snellinx A, Calafate S, Thal DR, Goate AM, De Strooper B. Chimeric models to analyze human neuron and astroglia responses in Alzheimer's disease Alzheimer's & Dementia. 16. DOI: 10.1002/alz.042678  0.239
2023 Balusu S, Praschberger R, Lauwers E, De Strooper B, Verstreken P. Neurodegeneration cell per cell. Neuron. 111: 767-786. PMID 36787752 DOI: 10.1016/j.neuron.2023.01.016  0.239
2021 Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, ... De Strooper B, et al. Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions. Cell. 184: 2257-2258. PMID 33861967 DOI: 10.1016/j.cell.2021.03.058  0.238
2018 Claes C, Van Den Daele J, Boon R, Schouteden S, Colombo A, Monasor LS, Fiers M, Ordovás L, Nami F, Bohrmann B, Tahirovic S, De Strooper B, Verfaillie CM. Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30442540 DOI: 10.1016/J.Jalz.2018.09.006  0.237
2016 Pigoni M, Wanngren J, Kuhn PH, Munro KM, Gunnersen JM, Takeshima H, Feederle R, Voytyuk I, De Strooper B, Levasseur MD, Hrupka BJ, Müller SA, Lichtenthaler SF. Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons. Molecular Neurodegeneration. 11: 67. PMID 27716410 DOI: 10.1186/s13024-016-0134-z  0.237
2017 Veugelen S, Dewilde M, De Strooper B, Chávez-Gutiérrez L. Screening and Characterization Strategies for Nanobodies Targeting Membrane Proteins. Methods in Enzymology. 584: 59-97. PMID 28065273 DOI: 10.1016/bs.mie.2016.10.029  0.237
2015 De Strooper B, Chávez Gutiérrez L. Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond. Annual Review of Pharmacology and Toxicology. 55: 419-37. PMID 25292430 DOI: 10.1146/annurev-pharmtox-010814-124309  0.236
2014 Lau P, Frigerio CS, De Strooper B. Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets. Ageing Research Reviews. 17: 43-53. PMID 24607832 DOI: 10.1016/j.arr.2014.02.006  0.236
2008 Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU. Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription. Experimental Cell Research. 314: 2419-33. PMID 18559276 DOI: 10.1016/J.Yexcr.2008.05.003  0.234
2005 De Strooper B. Nicastrin: gatekeeper of the gamma-secretase complex. Cell. 122: 318-20. PMID 16096051 DOI: 10.1016/j.cell.2005.07.021  0.233
2018 McInnes J, Wierda K, Snellinx A, Bounti L, Wang YC, Stancu IC, Apóstolo N, Gevaert K, Dewachter I, Spires-Jones TL, De Strooper B, De Wit J, Zhou L, Verstreken P. Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron. PMID 29398363 DOI: 10.1016/J.Neuron.2018.01.022  0.232
2015 Calafate S, Buist A, Miskiewicz K, Vijayan V, Daneels G, de Strooper B, de Wit J, Verstreken P, Moechars D. Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Reports. 11: 1176-83. PMID 25981034 DOI: 10.1016/j.celrep.2015.04.043  0.231
2012 Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, Gevaer K, De Strooper B. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo. The Journal of Biological Chemistry. 287: 25927-40. PMID 22692213 DOI: 10.1074/Jbc.M112.377465  0.23
2002 Hartmann D, de Strooper B, Serneels L, Craessaerts K, Herreman A, Annaert W, Umans L, Lübke T, Lena Illert A, von Figura K, Saftig P. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. Human Molecular Genetics. 11: 2615-24. PMID 12354787 DOI: 10.1093/Hmg/11.21.2615  0.23
2012 Esselens C, Sannerud R, Gallardo R, Baert V, Kaden D, Serneels L, De Strooper B, Rousseau F, Multhaup G, Schymkowitz J, Langedijk JP, Annaert W. Peptides based on the presenilin-APP binding domain inhibit APP processing and Aβ production through interfering with the APP transmembrane domain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3765-78. PMID 22661005 DOI: 10.1096/Fj.11-201368  0.23
2004 Marjaux E, De Strooper B. γ-secretase inhibitors: Still in the running as Alzheimer's therapeutics Drug Discovery Today: Therapeutic Strategies. 1: 1-6. DOI: 10.1016/j.ddstr.2004.05.001  0.228
2020 Koper MJ, Van Schoor E, Ospitalieri S, Vandenberghe R, Vandenbulcke M, von Arnim C, Tousseyn T, Reichwald J, Rabe S, Staufenbiel M, Balusu S, De Strooper B, Thal DR. Alzheimer’s disease‐related necroptotic pathology: An exclusive presence of the necrosome in granulovacuolar degeneration inclusions in human and transgenic mouse brains Alzheimer's & Dementia. 16. DOI: 10.1002/alz.042460  0.228
2023 Calafate S, Özturan G, Thrupp N, Vanderlinden J, Santa-Marinha L, Morais-Ribeiro R, Ruggiero A, Bozic I, Rusterholz T, Lorente-Echeverría B, Dias M, Chen WT, Fiers M, Lu A, Vlaeminck I, ... ... De Strooper B, et al. Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease. Nature Neuroscience. PMID 37188873 DOI: 10.1038/s41593-023-01325-4  0.228
2012 Vandersteen A, Masman MF, De Baets G, Jonckheere W, van der Werf K, Marrink SJ, Rozenski J, Benilova I, De Strooper B, Subramaniam V, Schymkowitz J, Rousseau F, Broersen K. Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool. The Journal of Biological Chemistry. 287: 36732-43. PMID 22992745 DOI: 10.1074/jbc.M112.394635  0.228
2023 Rué L, Jaspers T, Degors IMS, Noppen S, Schols D, De Strooper B, Dewilde M. Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics. Pharmaceutics. 15. PMID 37376196 DOI: 10.3390/pharmaceutics15061748  0.226
2004 Wrigley JD, Nunn EJ, Nyabi O, Clarke EE, Hunt P, Nadin A, De Strooper B, Shearman MS, Beher D. Conserved residues within the putative active site of gamma-secretase differentially influence enzyme activity and inhibitor binding. Journal of Neurochemistry. 90: 1312-20. PMID 15341515 DOI: 10.1111/j.1471-4159.2004.02596.x  0.222
2017 Voytyuk I, De Strooper B, Chávez-Gutiérrez L. Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease. Biological Psychiatry. PMID 28918941 DOI: 10.1016/j.biopsych.2017.08.001  0.22
2001 Annaert WG, Esselens C, Baert V, Boeve C, Snellings G, Cupers P, Craessaerts K, De Strooper B. Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins. Neuron. 32: 579-89. PMID 11719200 DOI: 10.1016/S0896-6273(01)00512-8  0.219
2019 Sachse SM, Lievens S, Ribeiro LF, Dascenco D, Masschaele D, Horré K, Misbaer A, Vanderroost N, De Smet AS, Salta E, Erfurth ML, Kise Y, Nebel S, Van Delm W, Plaisance S, ... ... De Strooper B, et al. Nuclear import of the DSCAM-cytoplasmic domain drives signaling capable of inhibiting synapse formation. The Embo Journal. PMID 30745319 DOI: 10.15252/embj.201899669  0.217
2011 Nelson O, Supnet C, Tolia A, Horré K, De Strooper B, Bezprozvanny I. Mutagenesis mapping of the presenilin 1 calcium leak conductance pore. The Journal of Biological Chemistry. 286: 22339-47. PMID 21531718 DOI: 10.1074/Jbc.M111.243063  0.217
2006 Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I. Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations. Cell. 126: 981-93. PMID 16959576 DOI: 10.1016/J.Cell.2006.06.059  0.216
2021 Fattorelli N, Martinez-Muriana A, Wolfs L, Geric I, De Strooper B, Mancuso R. Stem-cell-derived human microglia transplanted into mouse brain to study human disease. Nature Protocols. PMID 33424025 DOI: 10.1038/s41596-020-00447-4  0.216
2012 Mandemakers W, Snellinx A, O'Neill MJ, de Strooper B. LRRK2 expression is enriched in the striosomal compartment of mouse striatum. Neurobiology of Disease. 48: 582-93. PMID 22850484 DOI: 10.1016/j.nbd.2012.07.017  0.216
2021 Walgrave H, Zhou L, De Strooper B, Salta E. The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives. Molecular Neurodegeneration. 16: 76. PMID 34742333 DOI: 10.1186/s13024-021-00496-7  0.213
2011 Benilova I, De Strooper B. An overlooked neurotoxic species in Alzheimer's disease. Nature Neuroscience. 14: 949-50. PMID 21792191 DOI: 10.1038/nn.2871  0.213
2017 Zhou L, McInnes J, Wierda K, Holt M, Herrmann AG, Jackson RJ, Wang YC, Swerts J, Beyens J, Miskiewicz K, Vilain S, Dewachter I, Moechars D, De Strooper B, Spires-Jones TL, et al. Tau association with synaptic vesicles causes presynaptic dysfunction. Nature Communications. 8: 15295. PMID 28492240 DOI: 10.1038/Ncomms15295  0.212
2012 Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin F, De Strooper B, Dotti CG, Wahle T. Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell. 11: 63-72. PMID 22023223 DOI: 10.1111/J.1474-9726.2011.00760.X  0.212
2010 Jorissen E, De Strooper B. Gamma-secretase and the intramembrane proteolysis of Notch. Current Topics in Developmental Biology. 92: 201-30. PMID 20816396 DOI: 10.1016/S0070-2153(10)92006-1  0.21
2002 Leissring MA, Murphy MP, Mead TR, Akbari Y, Sugarman MC, Jannatipour M, Anliker B, Müller U, Saftig P, De Strooper B, Wolfe MS, Golde TE, LaFerla FM. A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proceedings of the National Academy of Sciences of the United States of America. 99: 4697-702. PMID 11917117 DOI: 10.1073/Pnas.072033799  0.21
2011 Zhou L, Chávez-Gutiérrez L, Bockstael K, Sannerud R, Annaert W, May PC, Karran E, De Strooper B. Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. The Journal of Biological Chemistry. 286: 8677-87. PMID 21209097 DOI: 10.1074/Jbc.M110.194860  0.209
2012 De Strooper B, Voet T. Alzheimer's disease: A protective mutation. Nature. 488: 38-9. PMID 22859199 DOI: 10.1038/488038a  0.209
2012 Carmeliet P, De Strooper B. Alzheimer's disease: A breach in the blood-brain barrier. Nature. 485: 451-2. PMID 22622564 DOI: 10.1038/485451a  0.208
2003 Lauwers E, Debyser Z, Van Dorpe J, De Strooper B, Nuttin B, Baekelandt V. Neuropathology and neurodegeneration in rodent brain induced by lentiviral vector-mediated overexpression of alpha-synuclein. Brain Pathology (Zurich, Switzerland). 13: 364-72. PMID 12946025 DOI: 10.1111/J.1750-3639.2003.Tb00035.X  0.207
2013 Thathiah A, Horre K, Snellinx A, Vandewyer E, Huang Y, Ciesielska M, De Kloe G, Munck S, De Strooper B. β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer’s disease Molecular Neurodegeneration. 8: P41. DOI: 10.1186/1750-1326-8-S1-P41  0.205
2006 Tolia A, Chávez-Gutiérrez L, De Strooper B. Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex. The Journal of Biological Chemistry. 281: 27633-42. PMID 16844686 DOI: 10.1074/jbc.M604997200  0.204
2009 Hébert SS, Horré K, Nicolaï L, Bergmans B, Papadopoulou AS, Delacourte A, De Strooper B. MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiology of Disease. 33: 422-8. PMID 19110058 DOI: 10.1016/J.Nbd.2008.11.009  0.201
2013 Sala Frigerio C, Lau P, Salta E, Tournoy J, Bossers K, Vandenberghe R, Wallin A, Bjerke M, Zetterberg H, Blennow K, De Strooper B. Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease. Neurology. 81: 2103-6. PMID 24212398 DOI: 10.1212/01.Wnl.0000437306.37850.22  0.2
2017 Schoonaert L, Rué L, Roucourt B, Timmers M, Little S, Chávez Gutiérrez L, Dewilde M, Joyce P, Curnock A, Weber P, Haustraete J, Hassanzadeh-Ghassabeh G, De Strooper B, Van Den Bosch L, Van Damme P, et al. Identification and Characterisation of Nanobodies targeting the EphA4 receptor. The Journal of Biological Chemistry. PMID 28526745 DOI: 10.1074/jbc.M116.774141  0.2
2006 Spasic D, Tolia A, Dillen K, Baert V, De Strooper B, Vrijens S, Annaert W. Presenilin-1 maintains a nine-transmembrane topology throughout the secretory pathway. The Journal of Biological Chemistry. 281: 26569-77. PMID 16846981 DOI: 10.1074/Jbc.M600592200  0.2
2011 Van Humbeeck C, Cornelissen T, Hofkens H, Mandemakers W, Gevaert K, De Strooper B, Vandenberghe W. Parkin interacts with Ambra1 to induce mitophagy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10249-61. PMID 21753002 DOI: 10.1523/JNEUROSCI.1917-11.2011  0.199
2013 Shariati SA, Lau P, Hassan BA, Müller U, Dotti CG, De Strooper B, Gärtner A. APLP2 regulates neuronal stem cell differentiation during cortical development. Journal of Cell Science. 126: 1268-77. PMID 23345401 DOI: 10.1242/Dev.098384  0.198
2016 Ryan NS, Nicholas JM, Weston PS, Liang Y, Lashley T, Guerreiro R, Adamson G, Kenny J, Beck J, Chavez-Gutierrez L, de Strooper B, Revesz T, Holton J, Mead S, Rossor MN, et al. Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series. The Lancet. Neurology. PMID 27777022 DOI: 10.1016/S1474-4422(16)30193-4  0.197
2004 Hébert SS, Serneels L, Dejaegere T, Horré K, Dabrowski M, Baert V, Annaert W, Hartmann D, De Strooper B. Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity. Neurobiology of Disease. 17: 260-72. PMID 15474363 DOI: 10.1016/J.Nbd.2004.08.002  0.197
2016 Katsnelson A, De Strooper B, Zoghbi HY. Neurodegeneration: From cellular concepts to clinical applications. Science Translational Medicine. 8: 364ps18. PMID 27831899 DOI: 10.1126/scitranslmed.aal2074  0.196
2014 De Kloe GE, De Strooper B. Small molecules that inhibit Notch signaling. Methods in Molecular Biology (Clifton, N.J.). 1187: 311-22. PMID 25053499 DOI: 10.1007/978-1-4939-1139-4_23  0.195
2015 Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L. The dynamic conformational landscape of gamma-secretase Nadav. Journal of Cell Science. 128: 589-98. PMID 25501811 DOI: 10.1242/jcs.164384  0.195
1999 De Strooper B, König G. Alzheimer's disease. A firm base for drug development. Nature. 402: 471-2. PMID 10591201 DOI: 10.1038/44973  0.194
2002 Baekelandt V, Claeys A, Eggermont K, Lauwers E, De Strooper B, Nuttin B, Debyser Z. Characterization of lentiviral vector-mediated gene transfer in adult mouse brain. Human Gene Therapy. 13: 841-53. PMID 11975850 DOI: 10.1089/10430340252899019  0.193
2001 Vincent B, Paitel E, Saftig P, Frobert Y, Hartmann D, De Strooper B, Grassi J, Lopez-Perez E, Checler F. The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. The Journal of Biological Chemistry. 276: 37743-6. PMID 11477090 DOI: 10.1074/jbc.M105677200  0.192
2022 Guo W, Wang H, Kumar Tharkeshwar A, Couthouis J, Braems E, Masrori P, Van Schoor E, Fan Y, Ahuja K, Moisse M, Jacquemyn M, Furtado Madeiro da Costa R, Gajjar M, Balusu S, Tricot T, ... ... De Strooper B, et al. CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35993441 DOI: 10.1002/alz.12760  0.191
2018 Gasse C, Zaarour M, Noppen S, Abramov M, Marlière P, Liekens S, De Strooper B, Herdewijn P. Modulation of BACE1 activity by chemically modified aptamers. Chembiochem : a European Journal of Chemical Biology. PMID 29327496 DOI: 10.1002/Cbic.201700461  0.189
2007 Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, Lichtenthaler SF. Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. The Journal of Biological Chemistry. 282: 11982-95. PMID 17307738 DOI: 10.1074/Jbc.M700356200  0.188
2010 Hébert SS, Papadopoulou AS, Smith P, Galas MC, Planel E, Silahtaroglu AN, Sergeant N, Buée L, De Strooper B. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Human Molecular Genetics. 19: 3959-69. PMID 20660113 DOI: 10.1093/Hmg/Ddq311  0.188
2002 Kang DE, Soriano S, Xia X, Eberhart CG, De Strooper B, Zheng H, Koo EH. Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell. 110: 751-62. PMID 12297048 DOI: 10.1016/S0092-8674(02)00970-4  0.186
2008 Tolia A, Horré K, De Strooper B. Transmembrane domain 9 of presenilin determines the dynamic conformation of the catalytic site of gamma-secretase. The Journal of Biological Chemistry. 283: 19793-803. PMID 18482978 DOI: 10.1074/jbc.M802461200  0.186
2013 Delbroek L, Van Kolen K, Steegmans L, da Cunha R, Mandemakers W, Daneels G, De Bock PJ, Zhang J, Gevaert K, De Strooper B, Alessi DR, Verstreken P, Moechars DW. Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. Journal of Pharmaceutical and Biomedical Analysis. 76: 49-58. PMID 23313773 DOI: 10.1016/J.Jpba.2012.12.002  0.184
2015 Barão S, Gärtner A, Leyva-Díaz E, Demyanenko G, Munck S, Vanhoutvin T, Zhou L, Schachner M, López-Bendito G, Maness PF, De Strooper B. Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse. Cell Reports. 12: 1367-76. PMID 26299962 DOI: 10.1016/J.Celrep.2015.07.059  0.184
2012 Cai J, Qi X, Kociok N, Skosyrski S, Emilio A, Ruan Q, Han S, Liu L, Chen Z, Bowes Rickman C, Golde T, Grant MB, Saftig P, Serneels L, de Strooper B, et al. β-Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment. Embo Molecular Medicine. 4: 980-91. PMID 22903875 DOI: 10.1002/Emmm.201101084  0.182
2008 Dejaegere T, Serneels L, Schäfer MK, Van Biervliet J, Horré K, Depboylu C, Alvarez-Fischer D, Herreman A, Willem M, Haass C, Höglinger GU, D'Hooge R, De Strooper B. Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment. Proceedings of the National Academy of Sciences of the United States of America. 105: 9775-80. PMID 18626010 DOI: 10.1073/Pnas.0800507105  0.181
2023 Serneels L, Narlawar R, Benito LP, Municoy M, Guallar V, T'Syen D, Dewilde M, Bischoff F, Fraiponts E, Tresadern G, Roevens PWM, Gijsen HJM, De Strooper B. Selective inhibitors of the PSEN1-gamma-secretase complex. The Journal of Biological Chemistry. 104794. PMID 37164155 DOI: 10.1016/j.jbc.2023.104794  0.18
2011 Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. Functional and topological analysis of Pen-2, the fourth subunit of the gamma-secretase complex. The Journal of Biological Chemistry. 286: 12271-82. PMID 21296884 DOI: 10.1074/jbc.M110.216978  0.18
2008 Chávez-Gutiérrez L, Tolia A, Maes E, Li T, Wong PC, de Strooper B. Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity. The Journal of Biological Chemistry. 283: 20096-105. PMID 18502756 DOI: 10.1074/Jbc.M803040200  0.18
2023 Serneels L, Bammens L, Zwijsen A, Tolia A, Chávez-Gutiérrez L, De Strooper B. Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex. The Journal of Biological Chemistry. 300: 105533. PMID 38072061 DOI: 10.1016/j.jbc.2023.105533  0.179
2016 Aerts L, Craessaerts K, De Strooper B, Morais VA. In Vitro Comparison of the Activity Requirements and Substrate Specificity of Human and Triboleum castaneum PINK1 Orthologues. Plos One. 11: e0146083. PMID 26784449 DOI: 10.1371/journal.pone.0146083  0.178
2000 Baekelandt V, De Strooper B, Nuttin B, Debyser Z. Gene therapeutic strategies for neurodegenerative diseases. Current Opinion in Molecular Therapeutics. 2: 540-54. PMID 11249757  0.178
2021 Largo-Barrientos P, Apóstolo N, Creemers E, Callaerts-Vegh Z, Swerts J, Davies C, McInnes J, Wierda K, De Strooper B, Spires-Jones T, de Wit J, Uytterhoeven V, Verstreken P. Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation. Neuron. PMID 33472038 DOI: 10.1016/j.neuron.2020.12.016  0.177
2014 Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch KP, Fitzsimons CP, De Strooper B, Rutten BP. Epigenetically regulated microRNAs in Alzheimer's disease. Neurobiology of Aging. 35: 731-45. PMID 24238656 DOI: 10.1016/j.neurobiolaging.2013.10.082  0.175
2022 Wouters Y, Jaspers T, Rué L, Serneels L, De Strooper B, Dewilde M. VHHs as tools for therapeutic protein delivery to the central nervous system. Fluids and Barriers of the Cns. 19: 79. PMID 36192747 DOI: 10.1186/s12987-022-00374-4  0.174
2020 Thrupp N, Sala Frigerio C, Wolfs L, Skene NG, Fattorelli N, Poovathingal S, Fourne Y, Matthews PM, Theys T, Mancuso R, de Strooper B, Fiers M. Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans. Cell Reports. 32: 108189. PMID 32997994 DOI: 10.1016/j.celrep.2020.108189  0.174
2005 Reiss K, Maretzky T, Ludwig A, Tousseyn T, de Strooper B, Hartmann D, Saftig P. ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. The Embo Journal. 24: 742-52. PMID 15692570 DOI: 10.1038/sj.emboj.7600671  0.172
2023 Walgrave H, Penning A, Tosoni G, Snoeck S, Davie K, Davis E, Wolfs L, Sierksma A, Mars M, Bu T, Thrupp N, Zhou L, Moechars D, Mancuso R, Fiers M, ... ... De Strooper B, et al. microRNA-132 regulates gene expression programs involved in microglial homeostasis. Iscience. 26: 106829. PMID 37250784 DOI: 10.1016/j.isci.2023.106829  0.17
2015 O'Flanagan CH, Morais VA, Wurst W, De Strooper B, O'Neill C. The Parkinson's gene PINK1 regulates cell cycle progression and promotes cancer-associated phenotypes. Oncogene. 34: 1363-74. PMID 24681957 DOI: 10.1038/Onc.2014.81  0.169
2017 Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG. Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. Plos One. 12: e0171968. PMID 28207852 DOI: 10.1371/Journal.Pone.0171968  0.168
2010 Morais VA, De Strooper B. Mitochondria dysfunction and neurodegenerative disorders: cause or consequence. Journal of Alzheimer's Disease : Jad. 20: S255-63. PMID 20463408 DOI: 10.3233/JAD-2010-100345  0.166
2013 Haddad DM, Vilain S, Vos M, Esposito G, Matta S, Kalscheuer VM, Craessaerts K, Leyssen M, Nascimento RM, Vianna-Morgante AM, De Strooper B, Van Esch H, Morais VA, Verstreken P. Mutations in the intellectual disability gene Ube2a cause neuronal dysfunction and impair parkin-dependent mitophagy. Molecular Cell. 50: 831-43. PMID 23685073 DOI: 10.1016/J.Molcel.2013.04.012  0.165
2018 Salas IH, De Strooper B. Diabetes and Alzheimer's Disease: A Link not as Simple as it Seems. Neurochemical Research. PMID 30523576 DOI: 10.1007/s11064-018-2690-9  0.165
2007 Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, de Strooper B, Janssen O, Saftig P. ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death and Differentiation. 14: 1040-9. PMID 17290285 DOI: 10.1038/sj.cdd.4402101  0.165
2007 Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I. Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1. The Journal of Clinical Investigation. 117: 1230-9. PMID 17431506 DOI: 10.1172/Jci30447  0.164
2014 Morais VA, Haddad D, Craessaerts K, De Bock PJ, Swerts J, Vilain S, Aerts L, Overbergh L, Grünewald A, Seibler P, Klein C, Gevaert K, Verstreken P, De Strooper B. PINK1 loss-of-function mutations affect mitochondrial complex I activity via NdufA10 ubiquinone uncoupling. Science (New York, N.Y.). 344: 203-7. PMID 24652937 DOI: 10.1126/Science.1249161  0.163
2011 Weber S, Niessen MT, Prox J, Lüllmann-Rauch R, Schmitz A, Schwanbeck R, Blobel CP, Jorissen E, de Strooper B, Niessen CM, Saftig P. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling. Development (Cambridge, England). 138: 495-505. PMID 21205794 DOI: 10.1242/Dev.055210  0.162
2017 Salta E, De Strooper B. microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 31: 424-433. PMID 28148775 DOI: 10.1096/fj.201601308  0.162
2016 Soukup SF, Kuenen S, Vanhauwaert R, Manetsberger J, Hernández-Díaz S, Swerts J, Schoovaerts N, Vilain S, Gounko NV, Vints K, Geens A, De Strooper B, Verstreken P. A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals. Neuron. PMID 27720484 DOI: 10.1016/J.Neuron.2016.09.037  0.161
2005 Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proceedings of the National Academy of Sciences of the United States of America. 102: 9182-7. PMID 15958533 DOI: 10.1073/Pnas.0500918102  0.16
2017 Salta E, De Strooper B. Noncoding RNAs in neurodegeneration. Nature Reviews. Neuroscience. PMID 28855739 DOI: 10.1038/nrn.2017.90  0.159
2005 Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. Developmental Cell. 8: 677-88. PMID 15866159 DOI: 10.1016/J.Devcel.2005.02.019  0.159
2009 Benilova I, Kuperstein I, Broersen K, Schymkowitz J, Rousseau F, Bartic C, De Strooper B. MEA neurosensor, the tool for synaptic activity detection: Acute amyloid- β oligomers synaptotoxicity study Ifmbe Proceedings. 25: 314-316. DOI: 10.1007/978-3-642-03887-7-91  0.158
2007 Mandemakers W, Morais VA, De Strooper B. A cell biological perspective on mitochondrial dysfunction in Parkinson disease and other neurodegenerative diseases. Journal of Cell Science. 120: 1707-16. PMID 17502481 DOI: 10.1242/jcs.03443  0.158
2020 Wouters Y, Jaspers T, De Strooper B, Dewilde M. Identification and in vivo characterization of a brain-penetrating nanobody. Fluids and Barriers of the Cns. 17: 62. PMID 33054787 DOI: 10.1186/s12987-020-00226-z  0.156
2013 Acx H, Gutiérrez LC, Serneels L, De Strooper B. The composition of the γ-secretase complex defines its Aβ product profile Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-P2  0.155
2017 Kemmerling N, Wunderlich P, Theil S, Linnartz-Gerlach B, Hersch N, Hoffmann B, Heneka MT, de Strooper B, Neumann H, Walter J. Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia. Glia. PMID 28370426 DOI: 10.1002/Glia.23147  0.155
2003 Schulz JG, Annaert W, Vandekerckhove J, Zimmermann P, De Strooper B, David G. Syndecan 3 intramembrane proteolysis is presenilin/gamma-secretase-dependent and modulates cytosolic signaling. The Journal of Biological Chemistry. 278: 48651-7. PMID 14504279 DOI: 10.1074/Jbc.M308424200  0.154
2005 Coolen MW, Van Loo KM, Van Bakel NN, Pulford DJ, Serneels L, De Strooper B, Ellenbroek BA, Cools AR, Martens GJ. Gene dosage effect on gamma-secretase component Aph-1b in a rat model for neurodevelopmental disorders. Neuron. 45: 497-503. PMID 15721236 DOI: 10.1016/j.neuron.2004.12.054  0.154
2019 Habets RA, de Bock CE, Serneels L, Lodewijckx I, Verbeke D, Nittner D, Narlawar R, Demeyer S, Dooley J, Liston A, Taghon T, Cools J, de Strooper B. Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Science Translational Medicine. 11. PMID 31142678 DOI: 10.1126/scitranslmed.aau6246  0.152
2020 Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, et al. LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. PMID 32894860 DOI: 10.1038/S41586-020-2715-9  0.152
2009 Tolia A, De Strooper B. Structure and function of gamma-secretase. Seminars in Cell & Developmental Biology. 20: 211-8. PMID 19007897 DOI: 10.1016/j.semcdb.2008.10.007  0.151
2021 Leonenko G, Baker E, Stevenson-Hoare J, Sierksma A, Fiers M, Williams J, de Strooper B, Escott-Price V. Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores. Nature Communications. 12: 4506. PMID 34301930 DOI: 10.1038/s41467-021-24082-z  0.15
2014 Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A, Shariati SA, Balschun D, De Strooper B. Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling. Elife. 3. PMID 24891237 DOI: 10.7554/Elife.02196  0.15
2003 Dabrowski M, Aerts S, Van Hummelen P, Craessaerts K, De Moor B, Annaert W, Moreau Y, De Strooper B. Gene profiling of hippocampal neuronal culture. Journal of Neurochemistry. 85: 1279-88. PMID 12753086 DOI: 10.1046/J.1471-4159.2003.01753.X  0.147
2021 Policarpo R, Sierksma A, De Strooper B, d'Ydewalle C. From Junk to Function: LncRNAs in CNS Health and Disease. Frontiers in Molecular Neuroscience. 14: 714768. PMID 34349622 DOI: 10.3389/fnmol.2021.714768  0.147
2022 Hardy J, de Strooper B, Escott-Price V. Diabetes and Alzheimer's disease: shared genetic susceptibility? The Lancet. Neurology. 21: 962-964. PMID 36270305 DOI: 10.1016/S1474-4422(22)00395-7  0.146
2016 Spinazzi M, De Strooper B. PARL: The mitochondrial rhomboid protease. Seminars in Cell & Developmental Biology. PMID 27502471 DOI: 10.1016/j.semcdb.2016.07.034  0.145
2019 Spinazzi M, Radaelli E, Horré K, Arranz AM, Gounko NV, Agostinis P, Maia TM, Impens F, Morais VA, Lopez-Lluch G, Serneels L, Navas P, De Strooper B. PARL deficiency in mouse causes Complex III defects, coenzyme Q depletion, and Leigh-like syndrome. Proceedings of the National Academy of Sciences of the United States of America. 116: 277-286. PMID 30578322 DOI: 10.1073/pnas.1811938116  0.142
2009 Ferjentsik Z, Hayashi S, Dale JK, Bessho Y, Herreman A, De Strooper B, del Monte G, de la Pompa JL, Maroto M. Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites. Plos Genetics. 5: e1000662. PMID 19779553 DOI: 10.1371/journal.pgen.1000662  0.14
2020 Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W. CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Human Molecular Genetics. PMID 32068847 DOI: 10.1093/hmg/ddaa028  0.14
2009 Morais VA, Verstreken P, Roethig A, Smet J, Snellinx A, Vanbrabant M, Haddad D, Frezza C, Mandemakers W, Vogt-Weisenhorn D, Van Coster R, Wurst W, Scorrano L, De Strooper B. Parkinson's disease mutations in PINK1 result in decreased Complex I activity and deficient synaptic function. Embo Molecular Medicine. 1: 99-111. PMID 20049710 DOI: 10.1002/Emmm.200900006  0.139
2011 Thimiri Govinda Raj DB, Ghesquière B, Tharkeshwar AK, Coen K, Derua R, Vanderschaeghe D, Rysman E, Bagadi M, Baatsen P, De Strooper B, Waelkens E, Borghs G, Callewaert N, Swinnen J, Gevaert K, et al. A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes. Molecular Systems Biology. 7: 541. PMID 22027552 DOI: 10.1038/Msb.2011.74  0.137
2013 Lau P, Bossers K, Janky R, Salta E, Frigerio CS, Barbash S, Rothman R, Sierksma AS, Thathiah A, Greenberg D, Papadopoulou AS, Achsel T, Ayoubi T, Soreq H, Verhaagen J, ... ... De Strooper B, et al. Alteration of the microRNA network during the progression of Alzheimer's disease. Embo Molecular Medicine. 5: 1613-34. PMID 24014289 DOI: 10.1002/Emmm.201201974  0.137
2023 Zhao J, Rostgaard K, Lauwers E, Dahlén T, Ostrowski SR, Erikstrup C, Pedersen OB, de Strooper B, Lemmens R, Hjalgrim H, Edgren G. Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients. Jama. 330: 941-950. PMID 37698562 DOI: 10.1001/jama.2023.14445  0.136
2000 Herreman A, Serneels L, Annaert W, Collen D, Schoonjans L, De Strooper B. Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nature Cell Biology. 2: 461-2. PMID 10878813 DOI: 10.1038/35017105  0.134
2022 Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, Dooley J, Kouser L, Verschoren S, Lagou V, Kemps H, Gervois P, de Boer A, Burton OT, Wahis J, ... ... De Strooper B, et al. Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation. Nature Immunology. 23: 878-891. PMID 35618831 DOI: 10.1038/s41590-022-01208-z  0.133
2014 Dorval V, Mandemakers W, Jolivette F, Coudert L, Mazroui R, De Strooper B, Hébert SS. Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. Plos One. 9: e85510. PMID 24427314 DOI: 10.1371/journal.pone.0085510  0.132
2023 Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, ... ... De Strooper B, et al. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. PMID 37100955 DOI: 10.1038/s41418-023-01153-w  0.13
2006 Debrock S, De Strooper B, Vander Perre S, Hill JA, D'Hooghe TM. Tumour necrosis factor-alpha, interleukin-6 and interleukin-8 do not promote adhesion of human endometrial epithelial cells to mesothelial cells in a quantitative in vitro model. Human Reproduction (Oxford, England). 21: 605-9. PMID 16253962 DOI: 10.1093/humrep/dei375  0.129
2017 Vos M, Geens A, Böhm C, Deaulmerie L, Swerts J, Rossi M, Craessaerts K, Leites EP, Seibler P, Rakovic A, Lohnau T, De Strooper B, Fendt SM, Morais VA, Klein C, et al. Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency. The Journal of Cell Biology. PMID 28137779 DOI: 10.1083/jcb.201511044  0.129
2002 Nyabi O, Pype S, Mercken M, Herreman A, Saftig P, Craessaerts K, Serneels L, Annaert W, De Strooper B. No endogenous A beta production in presenilin-deficient fibroblasts. Nature Cell Biology. 4: E164; author reply E. PMID 12105423 DOI: 10.1038/Ncb0702-E164A  0.127
2023 Ho H, Kejzar N, Sasaguri H, Saito T, Saido TC, De Strooper B, Bauza M, Krupic J. A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior. Cell Reports Methods. 3: 100532. PMID 37533650 DOI: 10.1016/j.crmeth.2023.100532  0.125
2017 Fazzari P, Horre K, Arranz AM, Frigerio CS, Saito T, Saido TC, De Strooper B. PLD3 gene and processing of APP. Nature. 541: E1-E2. PMID 28128235 DOI: 10.1038/Nature21030  0.125
2015 Arranz AM, Delbroek L, Van Kolen K, Guimarães MR, Mandemakers W, Daneels G, Matta S, Calafate S, Shaban H, Baatsen P, De Bock PJ, Gevaert K, Berghe PV, Verstreken P, De Strooper B, et al. LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism. Journal of Cell Science. 128: 541–52. PMID 25501810 DOI: 10.1242/Jcs.158196  0.125
2012 Matta S, Van Kolen K, da Cunha R, van den Bogaart G, Mandemakers W, Miskiewicz K, De Bock PJ, Morais VA, Vilain S, Haddad D, Delbroek L, Swerts J, Chávez-Gutiérrez L, Esposito G, Daneels G, ... ... De Strooper B, et al. LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron. 75: 1008-21. PMID 22998870 DOI: 10.1016/J.Neuron.2012.08.022  0.125
2004 Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Notch pathway is dispensable for adipocyte specification. Genesis (New York, N.Y. : 2000). 40: 40-4. PMID 15354292 DOI: 10.1002/Gene.20061  0.125
2011 Glomski K, Monette S, Manova K, De Strooper B, Saftig P, Blobel CP. Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. Blood. 118: 1163-74. PMID 21652679 DOI: 10.1182/Blood-2011-04-348557  0.125
2014 Fazzari P, Snellinx A, Sabanov V, Ahmed T, Serneels L, Gartner A, Shariati SAM, Balschun D, De Strooper B. Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling Elife. 2014. DOI: 10.7554/eLife.02196.001  0.124
2016 Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, ... ... de Strooper B, et al. Melanoma addiction to the long non-coding RNA SAMMSON. Nature. 531: 518-22. PMID 27008969 DOI: 10.1038/Nature17161  0.122
2012 Bezprozvanny I, Supnet C, Sun S, Zhang H, De Strooper B. Response to Shilling et al. (10.1074/jbc.M111.300491). The Journal of Biological Chemistry. 287: 20469; author reply . PMID 22685228 DOI: 10.1074/Jbc.L112.356790  0.122
2021 Escartin C, Galea E, Lakatos A, O'Callaghan JP, Petzold GC, Serrano-Pozo A, Steinhäuser C, Volterra A, Carmignoto G, Agarwal A, Allen NJ, Araque A, Barbeito L, Barzilai A, Bergles DE, ... ... De Strooper B, et al. Reactive astrocyte nomenclature, definitions, and future directions. Nature Neuroscience. PMID 33589835 DOI: 10.1038/s41593-020-00783-4  0.122
2022 De Strooper B, Zoghbi H. Editorial overview: Neurobiology of disease. Current Opinion in Neurobiology. 72: iv-ix. PMID 35248249 DOI: 10.1016/j.conb.2022.02.001  0.122
2006 Cipolat S, Rudka T, Hartmann D, Costa V, Serneels L, Craessaerts K, Metzger K, Frezza C, Annaert W, D'Adamio L, Derks C, Dejaegere T, Pellegrini L, D'Hooge R, Scorrano L, ... De Strooper B, et al. Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell. 126: 163-75. PMID 16839884 DOI: 10.1016/J.Cell.2006.06.021  0.119
2009 Hébert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends in Neurosciences. 32: 199-206. PMID 19268374 DOI: 10.1016/j.tins.2008.12.003  0.118
2012 Vilain S, Esposito G, Haddad D, Schaap O, Dobreva MP, Vos M, Van Meensel S, Morais VA, De Strooper B, Verstreken P. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. Plos Genetics. 8: e1002456. PMID 22242018 DOI: 10.1371/Journal.Pgen.1002456  0.117
2012 Salta E, De Strooper B. Non-coding RNAs with essential roles in neurodegenerative disorders. The Lancet. Neurology. 11: 189-200. PMID 22265214 DOI: 10.1016/S1474-4422(11)70286-1  0.117
2014 Cornelissen T, Haddad D, Wauters F, Van Humbeeck C, Mandemakers W, Koentjoro B, Sue C, Gevaert K, De Strooper B, Verstreken P, Vandenberghe W. The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Human Molecular Genetics. 23: 5227-42. PMID 24852371 DOI: 10.1093/hmg/ddu244  0.117
2014 Papadopoulou AS, Serneels L, Achsel T, Mandemakers W, Callaerts-Vegh Z, Dooley J, Lau P, Ayoubi T, Radaelli E, Spinazzi M, Neumann M, Hébert SS, Silahtaroglu A, Liston A, D'Hooge R, ... ... De Strooper B, et al. Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice. Neurobiology of Disease. 73: 275-288. PMID 25315682 DOI: 10.1016/J.Nbd.2014.10.006  0.117
2020 Pasciuto E, Burton OT, Roca CP, Lagou V, Rajan WD, Theys T, Mancuso R, Tito RY, Kouser L, Callaerts-Vegh Z, de la Fuente AG, Prezzemolo T, Mascali LG, Brajic A, Whyte CE, ... ... De Strooper B, et al. Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition. Cell. PMID 32702313 DOI: 10.1016/J.Cell.2020.06.026  0.116
2015 Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, et al. Errata to Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to SynapticDeficits in Fragile X Syndrome [Neuron, 87, (2015), 382-398] Neuron. 87: 908. DOI: 10.1016/J.Neuron.2015.08.010  0.115
2023 Narlawar R, Serneels L, Gaffric C, Gijsen HJM, De Strooper B, Bischoff F. Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors. European Journal of Medicinal Chemistry. 260: 115725. PMID 37657269 DOI: 10.1016/j.ejmech.2023.115725  0.115
2022 Aerts L, Miccoli B, Delahanty A, Witters H, Verstraelen S, De Strooper B, Braeken D, Verstreken P. Do we still need animals? Surveying the role of animal-free models in Alzheimer's and Parkinson's disease research. The Embo Journal. 41: e110002. PMID 35199384 DOI: 10.15252/embj.2021110002  0.115
2006 De Strooper B. S2-03-05: Cellular role of distinct Y-secretase complexes Alzheimer's & Dementia. 2: S27-S27. DOI: 10.1016/j.jalz.2006.05.092  0.113
2017 Hammad H, Vanderkerken M, Pouliot P, Deswarte K, Toussaint W, Vergote K, Vandersarren L, Janssens S, Ramou I, Savvides SN, Haigh JJ, Hendriks R, Kopf M, Craessaerts K, de Strooper B, et al. Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10. Nature Immunology. PMID 28068307 DOI: 10.1038/Ni.3657  0.112
2003 Murakami D, Okamoto I, Nagano O, Kawano Y, Tomita T, Iwatsubo T, De Strooper B, Yumoto E, Saya H. Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44. Oncogene. 22: 1511-6. PMID 12629514 DOI: 10.1038/sj.onc.1206298  0.109
2013 Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, ... ... De Strooper B, et al. The fragile X protein binds mRNAs involved in cancer progression and modulates metastasis formation. Embo Molecular Medicine. 5: 1523-36. PMID 24092663 DOI: 10.1002/Emmm.201302847  0.109
2015 Aerts L, De Strooper B, Morais VA. PINK1 activation-turning on a promiscuous kinase. Biochemical Society Transactions. 43: 280-6. PMID 25849930 DOI: 10.1042/BST20150002  0.108
2015 Aerts L, Craessaerts K, De Strooper B, Morais VA. PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402. The Journal of Biological Chemistry. 290: 2798-811. PMID 25527497 DOI: 10.1074/jbc.M114.620906  0.108
2021 Lalli G, Rossor M, Rowe JB, De Strooper B. The Dementia UK Ecosystem: a call to action. The Lancet. Neurology. 20: 699-700. PMID 34418390 DOI: 10.1016/S1474-4422(21)00246-5  0.105
2000 Baekelandt V, Claeys A, Cherepanov P, De Clercq E, De Strooper B, Nuttin B, Debyser Z. DNA-Dependent protein kinase is not required for efficient lentivirus integration. Journal of Virology. 74: 11278-85. PMID 11070027 DOI: 10.1128/Jvi.74.23.11278-11285.2000  0.102
2011 Bergmans BA, Dotti CG, De Strooper B. Neuronal differentiation of murine embryonic stem cells Human Mesenchymal and Embryonic Stem Cells. 175-190.  0.098
2004 Nagano O, Murakami D, Hartmann D, De Strooper B, Saftig P, Iwatsubo T, Nakajima M, Shinohara M, Saya H. Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation. The Journal of Cell Biology. 165: 893-902. PMID 15197174 DOI: 10.1083/jcb.200310024  0.097
2014 Lucá R, Averna M, Zalfa F, Vecchi M, Bianchi F, La Fata G, Del Nonno F, Nardacci R, Bianchi M, Nuciforo P, Munck S, Parrella P, Moura R, Signori E, Alston R, ... ... De Strooper B, et al. The Fragile X Protein binds mRNAs involved in cancer progression and modulates metastasis formation [EMBO Mol Med, 5, (2013) 1523-1536, DOI: 10.1002/emmm.201302847] Embo Molecular Medicine. 6: 567-568. DOI: 10.1002/Emmm.201470030  0.096
2023 Bammens L, Chávez-Gutiérrez L, Tolia A, Zwijsen A, De Strooper B. Withdrawal: Functional and topological analysis of Pen-2, the fourth subunit of the γ-secretase complex. The Journal of Biological Chemistry. 299: 104985. PMID 37413955 DOI: 10.1016/j.jbc.2023.104985  0.087
2005 Winters K, De Keersmaecker K, Bartic C, Braeken D, De Strooper B, Borghs G. Neuronal lithography with single cell resolution on chemically and topographically functionalised surfaces Proceedings of Spie - the International Society For Optical Engineering. 5839: 410-419. DOI: 10.1117/12.608208  0.086
2012 Zhou L, Barão S, Laga M, Bockstael K, Borgers M, Gijsen H, Annaert W, Moechars D, Mercken M, Gevaert K, De Strooper B. The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo (Journal of Biological Chemistry (2012) 287, (25927-25940)) Journal of Biological Chemistry. 287: 33719. DOI: 10.1074/jbc.A112.377465  0.082
2018 De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Smidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Dominguez Gonzalez E, Mack M, Depoortere I, De Strooper B, et al. Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis. Cell. PMID 30173915 DOI: 10.1016/j.cell.2018.07.048  0.081
2013 Vos M, Lovisa B, Geens A, Morais VA, Wagnières G, van den Bergh H, Ginggen A, De Strooper B, Tardy Y, Verstreken P. Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model. Plos One. 8: e78562. PMID 24244323 DOI: 10.1371/journal.pone.0078562  0.08
2006 Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko GV, Rudka T, Bartoli D, Polishuck RS, Danial NN, De Strooper B, Scorrano L. OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion. Cell. 126: 177-89. PMID 16839885 DOI: 10.1016/J.Cell.2006.06.025  0.078
2019 Zamparo I, Francia S, Franchi SA, Redolfi N, Costanzi E, Kerstens A, Fukutani Y, Battistutta R, Polverino de Laureto P, Munck S, De Strooper B, Matsunami H, Lodovichi C. Axonal Odorant Receptors Mediate Axon Targeting. Cell Reports. 29: 4334-4348.e7. PMID 31875544 DOI: 10.1016/j.celrep.2019.11.099  0.077
2012 Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, Zuklys S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A. The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor. Nature Immunology. 13: 181-7. PMID 22179202 DOI: 10.1038/ni.2193  0.07
2016 Chávez-Gutiérrez L, De Strooper B. Probing γ-secretase-substrate interactions at the single amino acid residue level. The Embo Journal. PMID 27370209 DOI: 10.15252/embj.201694978  0.069
2021 Aerts L, Lauwers E, De Strooper B. Dementia and COVID-19: a health and research funding crisis. The Lancet. Neurology. 20: 90. PMID 33484651 DOI: 10.1016/S1474-4422(21)00002-8  0.067
2020 Largo‐Barrientos P, de Strooper B, Spires‐Jones T, de Wit J, Uytterhoeven V, Verstreken P. Loss of synaptogyrin‐3 rescues tau‐induced memory defects and synaptic loss in the presence of microglial activation Alzheimer's & Dementia. 16. DOI: 10.1002/alz.047527  0.066
2001 De Strooper B, Annaert W. Where Notch and Wnt signaling meet. The presenilin hub. The Journal of Cell Biology. 152: F17-20. PMID 11266476 DOI: 10.1083/Jcb.152.4.F17  0.062
2014 Salta E, Lau P, Sala Frigerio C, Coolen M, Bally-Cuif L, De Strooper B. A self-organizing miR-132/Ctbp2 circuit regulates bimodal notch signals and glial progenitor fate choice during spinal cord maturation. Developmental Cell. 30: 423-36. PMID 25132384 DOI: 10.1016/j.devcel.2014.07.006  0.061
2003 Moreau Y, Aerts S, De Moor B, De Strooper B, Dabrowski M. Comparison and meta-analysis of microarray data: from the bench to the computer desk. Trends in Genetics : Tig. 19: 570-7. PMID 14550631 DOI: 10.1016/J.Tig.2003.08.006  0.058
2015 Hu W, Dooley J, Chung SS, Chandramohan D, Cimmino L, Mukherjee S, Mason CE, de Strooper B, Liston A, Park CY. miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a. Blood. 125: 2206-16. PMID 25634742 DOI: 10.1182/Blood-2014-06-585273  0.057
2021 Rajewsky N, Almouzni G, Gorski SA, Aerts S, Amit I, Bertero MG, Bock C, Bredenoord AL, Cavalli G, Chiocca S, Clevers H, De Strooper B, Eggert A, Ellenberg J, Fernández XM, et al. Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Nature. PMID 33731935 DOI: 10.1038/s41586-021-03287-8  0.056
2013 Mandemakers W, Abuhatzira L, Xu H, Caromile LA, Hébert SS, Snellinx A, Morais VA, Matta S, Cai T, Notkins AL, De Strooper B. Co-regulation of intragenic microRNA miR-153 and its host gene Ia-2 β: identification of miR-153 target genes with functions related to IA-2β in pancreas and brain. Diabetologia. 56: 1547-56. PMID 23595248 DOI: 10.1007/S00125-013-2901-5  0.055
2012 Vos M, Esposito G, Edirisinghe JN, Vilain S, Haddad DM, Slabbaert JR, Van Meensel S, Schaap O, De Strooper B, Meganathan R, Morais VA, Verstreken P. Vitamin K2 is a mitochondrial electron carrier that rescues pink1 deficiency. Science (New York, N.Y.). 336: 1306-10. PMID 22582012 DOI: 10.1126/Science.1218632  0.053
2017 Sassi Y, Avramopoulos P, Ramanujam D, Grüter L, Werfel S, Giosele S, Brunner AD, Esfandyari D, Papadopoulou AS, De Strooper B, Hübner N, Kumarswamy R, Thum T, Yin X, Mayr M, et al. Cardiac myocyte miR-29 promotes pathological remodeling of the heart by activating Wnt signaling. Nature Communications. 8: 1614. PMID 29158499 DOI: 10.1038/S41467-017-01737-4  0.051
2017 Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG. Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. Plos One. 12: e0187179. PMID 29065158 DOI: 10.1371/journal.pone.0187179  0.046
2017 Salas IH, Callaerts-Vegh Z, Arranz AM, Guix FX, D'Hooge R, Esteban JA, De Strooper B, Dotti CG. Correction: Tetraspanin 6: A novel regulator of hippocampal synaptic transmission and long term plasticity. Plos One. 12: e0178016. PMID 28686613 DOI: 10.1371/Journal.Pone.0178016  0.046
2016 Dooley J, Garcia-Perez JE, Sreenivasan J, Schlenner SM, Vangoitsenhoven R, Papadopoulou AS, Tian L, Schonefeldt S, Serneels L, Deroose C, Staats KA, Van der Schueren B, De Strooper B, McGuinness OP, Mathieu C, et al. The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity. Diabetes. 65: 53-61. PMID 26696639 DOI: 10.2337/Db15-0770  0.045
2007 Wakabayashi T, Iwatsubo T, De Strooper B. The biology of the presenilin complexes Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 35-58. DOI: 10.1007/978-0-387-35135-3_3  0.041
2013 De Strooper B. Secretases: potential and roadblocks on the way to therapy Molecular Neurodegeneration. 8. DOI: 10.1186/1750-1326-8-S1-O22  0.035
2001 De Strooper B, König G. An inflammatory drug prospect. Nature. 414: 159-60. PMID 11700538 DOI: 10.1038/35102656  0.03
2010 de Strooper B. Cancer and neurodegeneration meet. Embo Molecular Medicine. 2: 245-6. PMID 20583009 DOI: 10.1002/emmm.201000078  0.025
2019 De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, Voytyuk I, Schmidt I, Boeckx B, Dierckx de Casterlé I, Baekelandt V, Gonzalez Dominguez E, Mack M, Depoortere I, De Strooper B, et al. Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis. Cell. 176: 676. PMID 30682373 DOI: 10.1016/j.cell.2019.01.010  0.021
2007 Hébert SS, De Strooper B. Molecular biology. miRNAs in neurodegeneration. Science (New York, N.Y.). 317: 1179-80. PMID 17761871 DOI: 10.1126/science.1148530  0.02
1992 De Strooper B. [University education is more than higher education]. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van Belgiã«. 54: 631-6. PMID 1296407  0.01
Hide low-probability matches.