Year |
Citation |
Score |
2020 |
Maffioli E, Jiang Z, Nonnis S, Negri A, Romeo V, Lietz CB, Hook V, Ristagno G, Baselli G, Kistler EB, Aletti F, O'Donoghue AJ, Tedeschi G. High-Resolution Mass Spectrometry-Based Approaches for the Detection and Quantification of Peptidase Activity in Plasma. Molecules (Basel, Switzerland). 25. PMID 32899982 DOI: 10.3390/Molecules25184071 |
0.334 |
|
2020 |
Hook V, Yoon M, Mosier C, Ito G, Podvin S, Head BP, Rissman R, O'Donoghue AJ, Hook G. Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders. Biochimica Et Biophysica Acta. Proteins and Proteomics. 140428. PMID 32305689 DOI: 10.1016/J.Bbapap.2020.140428 |
0.322 |
|
2020 |
Podvin S, Jones A, Liu Q, Aulston B, Ransom LS, Ames J, Shen G, Lietz CB, Jiang Z, O'Donoghue AJ, Winston C, Ikezu T, Rissman R, Yuan S, Hook V. Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-Induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses. Molecular & Cellular Proteomics : McP. PMID 32295833 DOI: 10.1074/Mcp.Ra120.002079 |
0.348 |
|
2020 |
Boutte A, Hook V, Thangavelu B, Sarkis G, Abbatiello B, Hook G, Jacobsen JS, Robertson CS, Gilsdorf J, Yang Z, Wang KKW, Shear DA. Penetrating Traumatic Brain Injury Triggers Subacute Dysregulation of Cathepsin B Protein Levels Independently of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid. Journal of Neurotrauma. PMID 31973644 DOI: 10.1089/Neu.2019.6537 |
0.311 |
|
2019 |
Boudreau PD, Miller BW, McCall LI, Almaliti J, Reher R, Hirata K, Le T, Siqueira-Neto JL, Hook VYH, Gerwick WH. Design of gallinamide A analogs as potent inhibitors of the cysteine proteases human cathepsin L and Trypanosoma cruzi cruzain. Journal of Medicinal Chemistry. PMID 31539239 DOI: 10.1021/Acs.Jmedchem.9B00294 |
0.321 |
|
2019 |
Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki B, El-Sakkary N, Hook VYH, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ. The proteasome as a drug target in the metazoan pathogen, . Acs Infectious Diseases. PMID 31355632 DOI: 10.1021/Acsinfecdis.9B00237 |
0.344 |
|
2018 |
Podvin S, Wojnicz A, Hook V. Human brain gene expression profiles of the cathepsin V and cathepsin L cysteine proteases, with the PC1/3 and PC2 serine proteases, involved in neuropeptide production. Heliyon. 4: e00673. PMID 29998195 DOI: 10.1016/J.Heliyon.2018.E00673 |
0.342 |
|
2018 |
Hook V, Lietz CB, Podvin S, Cajka T, Fiehn O. Diversity of Neuropeptide Cell-Cell Signaling Molecules Generated by Proteolytic Processing Revealed by Neuropeptidomics Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 29667161 DOI: 10.1007/S13361-018-1914-1 |
0.423 |
|
2018 |
Lietz CB, Toneff T, Mosier C, Podvin S, O'Donoghue AJ, Hook V. Phosphopeptidomics Reveals Differential Phosphorylation States and Novel SxE Phosphosite Motifs of Neuropeptides in Dense Core Secretory Vesicles. Journal of the American Society For Mass Spectrometry. PMID 29556927 DOI: 10.1007/S13361-018-1915-0 |
0.383 |
|
2015 |
Hook V, Bandeira N. Neuropeptidomics Mass Spectrometry Reveals Signaling Networks Generated by Distinct Protease Pathways in Human Systems. Journal of the American Society For Mass Spectrometry. PMID 26483184 DOI: 10.1007/S13361-015-1251-6 |
0.343 |
|
2015 |
Hook V, Podvin S, Bundey R, Toneff T, Ziegler M. Profiles of secreted neuropeptides and catecholamines illustrate similarities and differences in response to stimulation by distinct secretagogues. Molecular and Cellular Neurosciences. PMID 26092702 DOI: 10.1016/J.Mcn.2015.06.008 |
0.301 |
|
2014 |
Cynis H, Funkelstein L, Toneff T, Mosier C, Ziegler M, Koch B, Demuth HU, Hook V. Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion. Neuro-Degenerative Diseases. 14: 85-97. PMID 24943989 DOI: 10.1159/000358430 |
0.385 |
|
2014 |
Hook G, Yu J, Toneff T, Kindy M, Hook V. Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic. Journal of Alzheimer's Disease : Jad. 41: 129-49. PMID 24595198 DOI: 10.3233/Jad-131370 |
0.383 |
|
2014 |
Miller B, Friedman AJ, Choi H, Hogan J, McCammon JA, Hook V, Gerwick WH. The marine cyanobacterial metabolite gallinamide A is a potent and selective inhibitor of human cathepsin L. Journal of Natural Products. 77: 92-9. PMID 24364476 DOI: 10.1021/Np400727R |
0.339 |
|
2014 |
Hook G, Yu J, Kindy MS, Hook V. P1-396: CYSTEINE PROTEASE INHIBITOR, E64D, OF CATHEPSIN B REDUCES PGLU-ABETA AND ABETA, AND IMPROVES MEMORY DEFICITS IN THE APPLON MOUSE MODEL OF AD Alzheimer's & Dementia. 10: P459-P459. DOI: 10.1016/J.Jalz.2014.05.638 |
0.348 |
|
2013 |
Toneff T, Funkelstein L, Mosier C, Abagyan A, Ziegler M, Hook V. Beta-amyloid peptides undergo regulated co-secretion with neuropeptide and catecholamine neurotransmitters. Peptides. 46: 126-35. PMID 23747840 DOI: 10.1016/J.Peptides.2013.04.020 |
0.425 |
|
2013 |
Hook V, Yu J, Hook G, Kindy M. O1-08-02: Cathepsin B produces brain pyro-glu-beta-amyloid in a transgenic Alzheimer's disease mouse model Alzheimer's & Dementia. 9: P143-P143. DOI: 10.1016/J.Jalz.2013.04.093 |
0.312 |
|
2012 |
Bark SJ, Wegrzyn J, Taupenot L, Ziegler M, O'Connor DT, Ma Q, Smoot M, Ideker T, Hook V. The protein architecture of human secretory vesicles reveals differential regulation of signaling molecule secretion by protein kinases. Plos One. 7: e41134. PMID 22916103 DOI: 10.1371/Journal.Pone.0041134 |
0.362 |
|
2012 |
Lu WD, Funkelstein L, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin H functions as an aminopeptidase in secretory vesicles for production of enkephalin and galanin peptide neurotransmitters. Journal of Neurochemistry. 122: 512-22. PMID 22582844 DOI: 10.1111/J.1471-4159.2012.07788.X |
0.411 |
|
2012 |
Funkelstein L, Lu WD, Koch B, Mosier C, Toneff T, Taupenot L, O'Connor DT, Reinheckel T, Peters C, Hook V. Human cathepsin V protease participates in production of enkephalin and NPY neuropeptide neurotransmitters. The Journal of Biological Chemistry. 287: 15232-41. PMID 22393040 DOI: 10.1074/Jbc.M111.310607 |
0.376 |
|
2012 |
Kindy MS, Yu J, Zhu H, El-Amouri SS, Hook V, Hook GR. Deletion of the cathepsin B gene improves memory deficits in a transgenic ALZHeimer's disease mouse model expressing AβPP containing the wild-type β-secretase site sequence. Journal of Alzheimer's Disease : Jad. 29: 827-40. PMID 22337825 DOI: 10.3233/Jad-2012-111604 |
0.3 |
|
2012 |
Lu WD, Liu T, Li S, Woods VL, Hook V. The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Science : a Publication of the Protein Society. 21: 178-87. PMID 22102294 DOI: 10.1002/Pro.2000 |
0.387 |
|
2012 |
Hook V, Funkelstein L, Wegrzyn J, Bark S, Kindy M, Hook G. Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease. Biochimica Et Biophysica Acta. 1824: 89-104. PMID 21925292 DOI: 10.1016/J.Bbapap.2011.08.015 |
0.473 |
|
2012 |
Hook V, Toneff T, Funkelstein L. Beta-amyloid peptides undergo activity-dependent secretion with neurotransmitters Alzheimers & Dementia. 8: 241. DOI: 10.1016/J.Jalz.2012.05.640 |
0.364 |
|
2012 |
Hook G, Yu J, Zhu H, El-Amouri S, Hook V, Kindy M. P2-359: Cathepsin B gene deletion or inhibition improves memory deficits in a mouse model of Alzheimer's disease expressing APP with the wild-type beta-secretase site Alzheimer's & Dementia. 8: P386-P387. DOI: 10.1016/J.Jalz.2012.05.1069 |
0.308 |
|
2011 |
Kim Y, Bark S, Hook V, Bandeira N. NeuroPedia: neuropeptide database and spectral library. Bioinformatics (Oxford, England). 27: 2772-3. PMID 21821666 DOI: 10.1093/Bioinformatics/Btr445 |
0.329 |
|
2011 |
Funkelstein L, Hook V. The novel role of cathepsin L for neuropeptide production illustrated by research strategies in chemical biology with protease gene knockout and expression. Methods in Molecular Biology (Clifton, N.J.). 768: 107-25. PMID 21805239 DOI: 10.1007/978-1-61779-204-5_5 |
0.393 |
|
2011 |
Hook G, Hook V, Kindy M. The cysteine protease inhibitor, E64d, reduces brain amyloid-β and improves memory deficits in Alzheimer's disease animal models by inhibiting cathepsin B, but not BACE1, β-secretase activity. Journal of Alzheimer's Disease : Jad. 26: 387-408. PMID 21613740 DOI: 10.3233/Jad-2011-110101 |
0.368 |
|
2011 |
Pham VL, Gouzy-Darmon C, Pernier J, Hanquez C, Hook V, Beinfeld MC, Nicolas P, Etchebest C, Foulon T, Cadel S. Mutation in the substrate-binding site of aminopeptidase B confers new enzymatic properties. Biochimie. 93: 730-41. PMID 21237246 DOI: 10.1016/J.Biochi.2010.12.015 |
0.306 |
|
2010 |
Funkelstein L, Beinfeld M, Minokadeh A, Zadina J, Hook V. Unique biological function of cathepsin L in secretory vesicles for biosynthesis of neuropeptides. Neuropeptides. 44: 457-66. PMID 21047684 DOI: 10.1016/J.Npep.2010.08.003 |
0.39 |
|
2010 |
Hook V, Bark S, Gupta N, Lortie M, Lu WD, Bandeira N, Funkelstein L, Wegrzyn J, O'Connor DT, Pevzner P. Neuropeptidomic components generated by proteomic functions in secretory vesicles for cell-cell communication. The Aaps Journal. 12: 635-45. PMID 20734175 DOI: 10.1208/S12248-010-9223-Z |
0.547 |
|
2010 |
Gupta N, Bark SJ, Lu WD, Taupenot L, O'Connor DT, Pevzner P, Hook V. Mass spectrometry-based neuropeptidomics of secretory vesicles from human adrenal medullary pheochromocytoma reveals novel peptide products of prohormone processing. Journal of Proteome Research. 9: 5065-75. PMID 20704348 DOI: 10.1021/Pr100358B |
0.562 |
|
2010 |
Wegrzyn JL, Bark SJ, Funkelstein L, Mosier C, Yap A, Kazemi-Esfarjani P, La Spada AR, Sigurdson C, O'Connor DT, Hook V. Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication. Journal of Proteome Research. 9: 5002-24. PMID 20695487 DOI: 10.1021/Pr1003104 |
0.35 |
|
2010 |
Hook V, Hook G, Kindy M. Pharmacogenetic features of cathepsin B inhibitors that improve memory deficit and reduce beta-amyloid related to Alzheimer's disease. Biological Chemistry. 391: 861-72. PMID 20536395 DOI: 10.1515/Bc.2010.110 |
0.349 |
|
2010 |
Watrous J, Burns K, Liu WT, Patel A, Hook V, Bafna V, Barry CE, Bark S, Dorrestein PC. Expansion of the mycobacterial "PUPylome". Molecular Biosystems. 6: 376-85. PMID 20094657 DOI: 10.1039/B916104J |
0.327 |
|
2010 |
Minokadeh A, Funkelstein L, Toneff T, Hwang SR, Beinfeld M, Reinheckel T, Peters C, Zadina J, Hook V. Cathepsin L participates in dynorphin production in brain cortex, illustrated by protease gene knockout and expression. Molecular and Cellular Neurosciences. 43: 98-107. PMID 19837164 DOI: 10.1016/J.Mcn.2009.10.001 |
0.348 |
|
2009 |
Lortie M, Bark S, Blantz R, Hook V. Detecting low-abundance vasoactive peptides in plasma: progress toward absolute quantitation using nano liquid chromatography-mass spectrometry. Analytical Biochemistry. 394: 164-70. PMID 19615967 DOI: 10.1016/J.Ab.2009.07.021 |
0.384 |
|
2009 |
Beinfeld MC, Funkelstein L, Foulon T, Cadel S, Kitagawa K, Toneff T, Reinheckel T, Peters C, Hook V. Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies. Peptides. 30: 1882-91. PMID 19589362 DOI: 10.1016/J.Peptides.2009.06.030 |
0.386 |
|
2009 |
Lee JC, Hook V. Proteolytic fragments of chromogranins A and B represent major soluble components of chromaffin granules, illustrated by two-dimensional proteomics with NH(2)-terminal Edman peptide sequencing and MALDI-TOF MS. Biochemistry. 48: 5254-62. PMID 19405523 DOI: 10.1021/Bi9002953 |
0.431 |
|
2009 |
Hook V, Funkelstein L, Toneff T, Mosier C, Hwang SR. Human pituitary contains dual cathepsin L and prohormone convertase processing pathway components involved in converting POMC into the peptide hormones ACTH, alpha-MSH, and beta-endorphin. Endocrine. 35: 429-37. PMID 19343278 DOI: 10.1007/s12020-009-9163-5 |
0.318 |
|
2009 |
Bark SJ, Lu WD, Hook V. Linear and accurate quantitation of proenkephalin-derived peptides by isotopic labeling with internal standards and mass spectrometry. Analytical Biochemistry. 389: 18-26. PMID 19289094 DOI: 10.1016/J.Ab.2009.03.010 |
0.376 |
|
2009 |
Lu WD, Asmus K, Hwang SR, Li S, Woods VL, Hook V. Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry. Biochemistry. 48: 1604-12. PMID 19173595 DOI: 10.1021/Bi801888J |
0.329 |
|
2009 |
Hwang SR, Bundey R, Toneff T, Hook V. Endopin serpin protease inhibitors localize with neuropeptides in secretory vesicles and neuroendocrine tissues. Neuroendocrinology. 89: 210-6. PMID 18840998 DOI: 10.1159/000162916 |
0.31 |
|
2008 |
Hook V, Schechter I, Demuth HU, Hook G. Alternative pathways for production of beta-amyloid peptides of Alzheimer's disease. Biological Chemistry. 389: 993-1006. PMID 18979625 DOI: 10.1515/Bc.2008.124 |
0.386 |
|
2008 |
Funkelstein L, Toneff T, Mosier C, Hwang SR, Beuschlein F, Lichtenauer UD, Reinheckel T, Peters C, Hook V. Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression. The Journal of Biological Chemistry. 283: 35652-9. PMID 18849346 DOI: 10.1074/Jbc.M709010200 |
0.388 |
|
2008 |
Hook V, Toneff T, Baylon S, Sei C. Differential activation of enkephalin, galanin, somatostatin, NPY, and VIP neuropeptide production by stimulators of protein kinases A and C in neuroendocrine chromaffin cells. Neuropeptides. 42: 503-11. PMID 18619673 DOI: 10.1016/J.Npep.2008.05.001 |
0.345 |
|
2008 |
Funkelstein L, Toneff T, Hwang SR, Reinheckel T, Peters C, Hook V. Cathepsin L participates in the production of neuropeptide Y in secretory vesicles, demonstrated by protease gene knockout and expression. Journal of Neurochemistry. 106: 384-91. PMID 18410501 DOI: 10.1111/J.1471-4159.2008.05408.X |
0.41 |
|
2008 |
Hook V, Funkelstein L, Lu D, Bark S, Wegrzyn J, Hwang SR. Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annual Review of Pharmacology and Toxicology. 48: 393-423. PMID 18184105 DOI: 10.1146/Annurev.Pharmtox.48.113006.094812 |
0.43 |
|
2007 |
Wegrzyn J, Lee J, Neveu JM, Lane WS, Hook V. Proteomics of neuroendocrine secretory vesicles reveal distinct functional systems for biosynthesis and exocytosis of peptide hormones and neurotransmitters. Journal of Proteome Research. 6: 1652-65. PMID 17408250 DOI: 10.1021/Pr060503P |
0.406 |
|
2007 |
Hook V, Kindy M, Hook G. Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease. Biological Chemistry. 388: 247-52. PMID 17261088 DOI: 10.1515/Bc.2007.027 |
0.364 |
|
2007 |
Hwang SR, Garza C, Mosier C, Toneff T, Wunderlich E, Goldsmith P, Hook V. Cathepsin L expression is directed to secretory vesicles for enkephalin neuropeptide biosynthesis and secretion. The Journal of Biological Chemistry. 282: 9556-63. PMID 17244622 DOI: 10.1074/Jbc.M605510200 |
0.416 |
|
2007 |
Hwang SR, O'Neill A, Bark S, Foulon T, Hook V. Secretory vesicle aminopeptidase B related to neuropeptide processing: molecular identification and subcellular localization to enkephalin- and NPY-containing chromaffin granules. Journal of Neurochemistry. 100: 1340-50. PMID 17241125 DOI: 10.1111/J.1471-4159.2006.04325.X |
0.389 |
|
2006 |
Hook VY. Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biological Chemistry. 387: 1429-39. PMID 17081116 DOI: 10.1515/BC.2006.179 |
0.355 |
|
2006 |
Hook VY. Protease pathways in peptide neurotransmission and neurodegenerative diseases. Cellular and Molecular Neurobiology. 26: 449-69. PMID 16724274 DOI: 10.1007/s10571-006-9047-7 |
0.332 |
|
2006 |
Hook VY. Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 20: 105-19. PMID 16626168 DOI: 10.2165/00063030-200620020-00005 |
0.32 |
|
2005 |
Hook V, Toneff T, Bogyo M, Greenbaum D, Medzihradszky KF, Neveu J, Lane W, Hook G, Reisine T. Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. Biological Chemistry. 386: 931-40. PMID 16164418 DOI: 10.1515/Bc.2005.108 |
0.351 |
|
2004 |
Hook V, Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Troutner K, Toneff T, Bundey R, Logrinova A, Reinheckel T, Peters C, Bogyo M. Cathepsin L and Arg/Lys aminopeptidase: a distinct prohormone processing pathway for the biosynthesis of peptide neurotransmitters and hormones. Biological Chemistry. 385: 473-80. PMID 15255178 DOI: 10.1515/Bc.2004.055 |
0.427 |
|
2003 |
Yasothornsrikul S, Greenbaum D, Medzihradszky KF, Toneff T, Bundey R, Miller R, Schilling B, Petermann I, Dehnert J, Logvinova A, Goldsmith P, Neveu JM, Lane WS, Gibson B, Reinheckel T, ... ... Hook V, et al. Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter. Proceedings of the National Academy of Sciences of the United States of America. 100: 9590-5. PMID 12869695 DOI: 10.1073/Pnas.1531542100 |
0.446 |
|
2003 |
Lee JC, Taylor CV, Gaucher SP, Toneff T, Taupenot L, Yasothornsrikul S, Mahata SK, Sei C, Parmer RJ, Neveu JM, Lane WS, Gibson BW, O'Connor DT, Hook VY. Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells. Biochemistry. 42: 6938-46. PMID 12795588 DOI: 10.1021/Bi0300433 |
0.307 |
|
2002 |
Hook V, Metz-Boutigue MH. Protein trafficking to chromaffin granules and proteolytic processing within regulated secretory vesicles of neuroendocrine chromaffin cells. Annals of the New York Academy of Sciences. 971: 397-405. PMID 12438158 DOI: 10.1111/J.1749-6632.2002.Tb04502.X |
0.399 |
|
2000 |
Taylor CV, Taupenot L, Mahata SK, Mahata M, Wu H, Yasothornsrikul S, Toneff T, Caporale C, Jiang Q, Parmer RJ, Hook VY, O'Connor DT. Formation of the catecholamine release-inhibitory peptide catestatin from chromogranin A. Determination of proteolytic cleavage sites in hormone storage granules. The Journal of Biological Chemistry. 275: 22905-15. PMID 10781584 DOI: 10.1074/Jbc.M001232200 |
0.301 |
|
1999 |
Hook VY, Sei C, Yasothornsrikul S, Toneff T, Kang YH, Efthimiopoulos S, Robakis NK, Van Nostrand W. The kunitz protease inhibitor form of the amyloid precursor protein (KPI/APP) inhibits the proneuropeptide processing enzyme prohormone thiol protease (PTP). Colocalization of KPI/APP and PTP in secretory vesicles. The Journal of Biological Chemistry. 274: 3165-72. PMID 9915856 DOI: 10.1074/jbc.274.5.3165 |
0.317 |
|
1994 |
Azaryan AV, Hook VY. Distinct properties of prohormone thiol protease (PTP) compared to cathepsins B, L, and H: evidence for PTP as a novel cysteine protease. Archives of Biochemistry and Biophysics. 314: 171-7. PMID 7944391 DOI: 10.1006/abbi.1994.1426 |
0.309 |
|
1993 |
Hook VY, Purviance RT, Azaryan AV, Hubbard G, Krieger TJ. Purification and characterization of alpha 1-antichymotrypsin-like protease inhibitor that regulates prohormone thiol protease involved in enkephalin precursor processing. The Journal of Biological Chemistry. 268: 20570-7. PMID 8376411 |
0.334 |
|
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