| Year |
Citation |
Score |
| 2023 |
Gil-Henn H, Girault JA, Lev S. PYK2, a hub of signaling networks in breast cancer progression. Trends in Cell Biology. PMID 37586982 DOI: 10.1016/j.tcb.2023.07.006 |
0.669 |
|
| 2022 |
Nataraj NB, Noronha A, Lee JS, Ghosh S, Mohan Raju HR, Sekar A, Zuckerman B, Lindzen M, Tarcitano E, Srivastava S, Selitrennik M, Livneh I, Drago-Garcia D, Rueda O, Caldas C, Lev S, et al. Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors. Cell Reports. 38: 110418. PMID 35196484 DOI: 10.1016/j.celrep.2022.110418 |
0.787 |
|
| 2022 |
Müller AK, Köhler UA, Trzebanski S, Vinik Y, Raj HM, Girault JA, Ben-Chetrit N, Maraver A, Jung S, Lev S. Mouse Modeling Dissecting Macrophage-Breast Cancer Communication Uncovered Roles of PYK2 in Macrophage Recruitment and Breast Tumorigenesis. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2105696. PMID 35092356 DOI: 10.1002/advs.202105696 |
0.644 |
|
| 2021 |
Castellanet O, Ahmad F, Vinik Y, Mills GB, Habermann B, Borg JP, Lev S, Lamballe F, Maina F. BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators. Theranostics. 11: 9180-9197. PMID 34646365 DOI: 10.7150/thno.60503 |
0.714 |
|
| 2021 |
Khera L, Lev S. Accelerating AXL targeting for TNBC therapy. The International Journal of Biochemistry & Cell Biology. 106057. PMID 34403827 DOI: 10.1016/j.biocel.2021.106057 |
0.659 |
|
| 2021 |
Khera L, Vinik Y, Maina F, Lev S. The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBC. Life Science Alliance. 4. PMID 33785524 DOI: 10.26508/lsa.202000985 |
0.659 |
|
| 2021 |
Lamballe F, Ahmad F, Vinik Y, Castellanet O, Daian F, Müller AK, Köhler UA, Bailly AL, Josselin E, Castellano R, Cayrou C, Charafe-Jauffret E, Mills GB, Géli V, Borg JP, Lev S, et al. Modeling Heterogeneity of Triple-Negative Breast Cancer Uncovers a Novel Combinatorial Treatment Overcoming Primary Drug Resistance. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 8: 2003049. PMID 33552868 DOI: 10.1002/advs.202003049 |
0.696 |
|
| 2020 |
Vinik Y, Ortega FG, Mills GB, Lu Y, Jurkowicz M, Halperin S, Aharoni M, Gutman M, Lev S. Proteomic analysis of circulating extracellular vesicles identifies potential markers of breast cancer progression, recurrence, and response. Science Advances. 6. PMID 33008904 DOI: 10.1126/sciadv.aba5714 |
0.671 |
|
| 2020 |
Verma N, Vinik Y, Saroha A, Nair NU, Ruppin E, Mills G, Karn T, Dubey V, Khera L, Raj H, Maina F, Lev S. Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis. Science Advances. 6. PMID 32937365 DOI: 10.1126/Sciadv.Aba8968 |
0.79 |
|
| 2020 |
Shatz-Azoulay H, Vinik Y, Isaac R, Kohler U, Lev S, Zick Y. The Animal Lectin Galectin-8 Promotes Cytokine Expression and Metastatic Tumor Growth in Mice. Scientific Reports. 10: 7375. PMID 32355198 DOI: 10.1038/S41598-020-64371-Z |
0.628 |
|
| 2020 |
Lev S. Targeted therapy and drug resistance in triple-negative breast cancer: the EGFR axis. Biochemical Society Transactions. 48: 657-665. PMID 32311020 DOI: 10.1042/BST20191055 |
0.653 |
|
| 2020 |
Verma N, Müller AK, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S. Correction: Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4-NDRG1 Axis. Cancer Research. 80: 362. PMID 31941679 DOI: 10.1158/0008-5472.CAN-19-3573 |
0.745 |
|
| 2019 |
Peretti D, Kim S, Tufi R, Lev S. Lipid Transfer Proteins and Membrane Contact Sites in Human Cancer. Frontiers in Cell and Developmental Biology. 7: 371. PMID 32039198 DOI: 10.3389/Fcell.2019.00371 |
0.796 |
|
| 2019 |
Keinan O, Kedan A, Gavert N, Selitrennik M, Kim S, Karn T, Becker S, Lev S. Correction: The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis (doi:10.1242/jcs.155721). Journal of Cell Science. 132. PMID 30846603 DOI: 10.1242/Jcs.227868 |
0.756 |
|
| 2018 |
Kedan A, Verma N, Saroha A, Shreberk-Shaked M, Müller AK, Nair NU, Lev S. PYK2 negatively regulates the Hippo pathway in TNBC by stabilizing TAZ protein. Cell Death & Disease. 9: 985. PMID 30250159 DOI: 10.1038/S41419-018-1005-Z |
0.811 |
|
| 2018 |
Shin SY, Müller AK, Verma N, Lev S, Nguyen LK. Systems modelling of the EGFR-PYK2-c-Met interaction network predicts and prioritizes synergistic drug combinations for triple-negative breast cancer. Plos Computational Biology. 14: e1006192. PMID 29920512 DOI: 10.1371/Journal.Pcbi.1006192 |
0.806 |
|
| 2017 |
Panayotopoulou EG, Müller AK, Börries M, Busch H, Hu G, Lev S. Targeting of apoptotic pathways by SMAC or BH3 mimetics distinctly sensitizes paclitaxel-resistant triple negative breast cancer cells. Oncotarget. PMID 28187446 DOI: 10.18632/oncotarget.15125 |
0.795 |
|
| 2016 |
Yu J, Lei R, Zhuang X, Li X, Li G, Lev S, Segura MF, Zhang X, Hu G. MicroRNA-182 targets SMAD7 to potentiate TGFβ-induced epithelial-mesenchymal transition and metastasis of cancer cells. Nature Communications. 7: 13884. PMID 27996004 DOI: 10.1038/ncomms13884 |
0.638 |
|
| 2016 |
Verma N, Müller AK, Kothari C, Panayotopoulou E, Kedan A, Selitrennik M, Mills GB, Nguyen LK, Shin S, Karn T, Holtrich U, Lev S. Targeting of PYK2 synergizes with EGFR antagonists in basal-like TNBC and circumvents HER3-associated resistance via the NEDD4-NDRG1 axis. Cancer Research. PMID 27793840 DOI: 10.1158/0008-5472.Can-16-1797 |
0.78 |
|
| 2016 |
Selitrennik M, Lev S. The role of phosphatidylinositol-transfer proteins at membrane contact sites. Biochemical Society Transactions. 44: 419-24. PMID 27068949 DOI: 10.1042/BST20150182 |
0.805 |
|
| 2015 |
Selitrennik M, Lev S. PYK2 integrates growth factor and cytokine receptors signaling and potentiates breast cancer invasion via a positive feedback loop. Oncotarget. 6: 22214-26. PMID 26084289 DOI: 10.18632/oncotarget.4257 |
0.81 |
|
| 2015 |
Verma N, Keinan O, Selitrennik M, Karn T, Filipits M, Lev S. PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition. Nature Communications. 6: 6064. PMID 25648557 DOI: 10.1038/Ncomms7064 |
0.798 |
|
| 2014 |
Keinan O, Kedan A, Gavert N, Selitrennik M, Kim S, Karn T, Becker S, Lev S. The lipid-transfer protein Nir2 enhances epithelial-mesenchymal transition and facilitates breast cancer metastasis. Journal of Cell Science. 127: 4740-9. PMID 25179602 DOI: 10.1242/Jcs.155721 |
0.772 |
|
| 2014 |
Hong W, Lev S. Tethering the assembly of SNARE complexes. Trends in Cell Biology. 24: 35-43. PMID 24119662 DOI: 10.1016/j.tcb.2013.09.006 |
0.65 |
|
| 2013 |
Kim S, Kedan A, Marom M, Gavert N, Keinan O, Selitrennik M, Laufman O, Lev S. The phosphatidylinositol-transfer protein Nir2 binds phosphatidic acid and positively regulates phosphoinositide signalling. Embo Reports. 14: 891-9. PMID 23897088 DOI: 10.1038/Embor.2013.113 |
0.758 |
|
| 2013 |
Laufman O, Freeze HH, Hong W, Lev S. Deficiency of the Cog8 subunit in normal and CDG-derived cells impairs the assembly of the COG and Golgi SNARE complexes. Traffic (Copenhagen, Denmark). 14: 1065-77. PMID 23865579 DOI: 10.1111/Tra.12093 |
0.777 |
|
| 2013 |
Laufman O, Hong W, Lev S. The COG complex interacts with multiple Golgi SNAREs and enhances fusogenic assembly of SNARE complexes. Journal of Cell Science. 126: 1506-16. PMID 23378023 DOI: 10.1242/Jcs.122101 |
0.783 |
|
| 2012 |
Rao M, Song W, Jiang A, Shyr Y, Lev S, Greenstein D, Brantley-Sieders D, Chen J. VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity. Plos One. 7: e46281. PMID 23049696 DOI: 10.1371/Journal.Pone.0046281 |
0.66 |
|
| 2012 |
Lev S. Nonvesicular lipid transfer from the endoplasmic reticulum. Cold Spring Harbor Perspectives in Biology. 4. PMID 23028121 DOI: 10.1101/cshperspect.a013300 |
0.633 |
|
| 2011 |
Laufman O, Hong W, Lev S. The COG complex interacts directly with Syntaxin 6 and positively regulates endosome-to-TGN retrograde transport. The Journal of Cell Biology. 194: 459-72. PMID 21807881 DOI: 10.1083/Jcb.201102045 |
0.793 |
|
| 2010 |
Lev S. Non-vesicular lipid transport by lipid-transfer proteins and beyond. Nature Reviews. Molecular Cell Biology. 11: 739-50. PMID 20823909 DOI: 10.1038/nrm2971 |
0.631 |
|
| 2010 |
Kim S, Leal SS, Ben Halevy D, Gomes CM, Lev S. Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity. The Journal of Biological Chemistry. 285: 13839-49. PMID 20207736 DOI: 10.1074/Jbc.M109.097345 |
0.775 |
|
| 2009 |
Laufman O, Kedan A, Hong W, Lev S. Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. The Embo Journal. 28: 2006-17. PMID 19536132 DOI: 10.1038/Emboj.2009.168 |
0.778 |
|
| 2008 |
Krishnan MN, Ng A, Sukumaran B, Gilfoy FD, Uchil PD, Sultana H, Brass AL, Adametz R, Tsui M, Qian F, Montgomery RR, Lev S, Mason PW, Koski RA, Elledge SJ, et al. RNA interference screen for human genes associated with West Nile virus infection. Nature. 455: 242-5. PMID 18690214 DOI: 10.1038/Nature07207 |
0.605 |
|
| 2008 |
Peretti D, Dahan N, Shimoni E, Hirschberg K, Lev S. Coordinated lipid transfer between the endoplasmic reticulum and the Golgi complex requires the VAP proteins and is essential for Golgi-mediated transport. Molecular Biology of the Cell. 19: 3871-84. PMID 18614794 DOI: 10.1091/Mbc.E08-05-0498 |
0.793 |
|
| 2008 |
Lev S, Ben Halevy D, Peretti D, Dahan N. The VAP protein family: from cellular functions to motor neuron disease. Trends in Cell Biology. 18: 282-90. PMID 18468439 DOI: 10.1016/J.Tcb.2008.03.006 |
0.776 |
|
| 2006 |
Lev S. Lipid homoeostasis and Golgi secretory function Biochemical Society Transactions. 34: 363-366. PMID 16709162 DOI: 10.1042/BST0340363 |
0.645 |
|
| 2005 |
Litvak V, Dahan N, Ramachandran S, Sabanay H, Lev S. Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function. Nature Cell Biology. 7: 225-34. PMID 15723057 DOI: 10.1038/Ncb1221 |
0.804 |
|
| 2005 |
Amarilio R, Ramachandran S, Sabanay H, Lev S. Differential regulation of endoplasmic reticulum structure through VAP-Nir protein interaction. The Journal of Biological Chemistry. 280: 5934-44. PMID 15545272 DOI: 10.1074/jbc.M409566200 |
0.632 |
|
| 2005 |
Corvol JC, Valjent E, Toutant M, Enslen H, Irinopoulou T, Lev S, Hervé D, Girault JA. Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices. The Journal of Biological Chemistry. 280: 660-8. PMID 15537634 DOI: 10.1074/jbc.M411312200 |
0.653 |
|
| 2004 |
Rolls A, Avidan H, Cahalon L, Schori H, Bakalash S, Litvak V, Lev S, Lider O, Schwartz M. A disaccharide derived from chondroitin sulphate proteoglycan promotes central nervous system repair in rats and mice. The European Journal of Neuroscience. 20: 1973-83. PMID 15450076 DOI: 10.1111/J.1460-9568.2004.03676.X |
0.704 |
|
| 2004 |
Lev S. The role of the Nir/rdgB protein family in membrane trafficking and cytoskeleton remodeling. Experimental Cell Research. 297: 1-10. PMID 15194420 DOI: 10.1016/j.yexcr.2004.02.033 |
0.649 |
|
| 2004 |
Litvak V, Argov R, Dahan N, Ramachandran S, Amarilio R, Shainskaya A, Lev S. Mitotic phosphorylation of the peripheral Golgi protein Nir2 by Cdk1 provides a docking mechanism for Plk1 and affects cytokinesis completion. Molecular Cell. 14: 319-30. PMID 15125835 DOI: 10.1016/S1097-2765(04)00214-X |
0.796 |
|
| 2003 |
Rubin C, Litvak V, Medvedovsky H, Zwang Y, Lev S, Yarden Y. Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. Current Biology : Cb. 13: 297-307. PMID 12593795 DOI: 10.1016/S0960-9822(03)00053-8 |
0.81 |
|
| 2002 |
Litvak V, Shaul YD, Shulewitz M, Amarilio R, Carmon S, Lev S. Targeting of Nir2 to lipid droplets is regulated by a specific threonine residue within its PI-transfer domain. Current Biology : Cb. 12: 1513-8. PMID 12225667 DOI: 10.1016/S0960-9822(02)01107-7 |
0.743 |
|
| 2002 |
Litvak V, Tian D, Carmon S, Lev S. Nir2, a human homolog of Drosophila melanogaster retinal degeneration B protein, is essential for cytokinesis. Molecular and Cellular Biology. 22: 5064-75. PMID 12077336 DOI: 10.1128/Mcb.22.14.5064-5075.2002 |
0.751 |
|
| 2002 |
Tian D, Lev S. Cellular and developmental distribution of human homologues of the Drosophilia rdgB protein in the rat retina. Investigative Ophthalmology & Visual Science. 43: 1946-53. PMID 12037004 |
0.566 |
|
| 2002 |
Tian D, Litvak V, Toledo-Rodriguez M, Carmon S, Lev S. Nir2, a novel regulator of cell morphogenesis. Molecular and Cellular Biology. 22: 2650-62. PMID 11909959 DOI: 10.1128/Mcb.22.8.2650-2662.2002 |
0.744 |
|
| 2001 |
Lev S. Molecular aspects of retinal degenerative diseases Cellular and Molecular Neurobiology. 21: 575-589. PMID 12043834 DOI: 10.1023/A:1015183500719 |
0.558 |
|
| 2000 |
Tian D, Litvak V, Lev S. Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6478-87. PMID 10964954 DOI: 10.1523/Jneurosci.20-17-06478.2000 |
0.731 |
|
| 2000 |
Litvak V, Tian D, Shaul YD, Lev S. Targeting of PYK2 to focal adhesions as a cellular mechanism for convergence between integrins and G protein-coupled receptor signaling cascades. The Journal of Biological Chemistry. 275: 32736-46. PMID 10915788 DOI: 10.1074/Jbc.M004200200 |
0.766 |
|
| 2000 |
Ling S, Woronuk G, Sy L, Lev S, Braun AP. Enhanced activity of a large conductance, calcium-sensitive K+ channel in the presence of Src tyrosine kinase. The Journal of Biological Chemistry. 275: 30683-9. PMID 10893418 DOI: 10.1074/Jbc.M004292200 |
0.608 |
|
| 1996 |
Dikic I, Tokiwa G, Lev S, Courtneidge SA, Schlessinger J. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature. 383: 547-50. PMID 8849729 DOI: 10.1038/383547A0 |
0.785 |
|
| 1996 |
Tokiwa G, Dikic I, Lev S, Schlessinger J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science (New York, N.Y.). 273: 792-4. PMID 8670418 DOI: 10.1126/Science.273.5276.792 |
0.783 |
|
| 1995 |
Blechman JM, Lev S, Barg J, Eisenstein M, Vaks B, Vogel Z, Givol D, Yarden Y.. The fourth immunoglobulin domain of the stem cell factor receptor couples ligand binding to signal transduction. Cell. 80: 103-113. PMID 7529140 DOI: 10.1016/0092-8674(95)90455-7 |
0.747 |
|
| 1994 |
Lev S, Blechman JM, Givol D, Yarden Y. Steel factor and c-kit protooncogene: Genetic lessons in signal transduction Critical Reviews in Oncogenesis. 5: 141-168. PMID 7531500 DOI: 10.1615/Critrevoncog.V5.I2-3.30 |
0.658 |
|
| 1994 |
Lev S, Blechman JM, Givol D, Yarden Y.. Steel factor and c-kit protooncogene: genetic lessons in signal transduction. Crit Rev Oncog.. 5: 141-68. PMID 7531500 DOI: 10.1615/critrevoncog.v5.i2-3.30 |
0.777 |
|
| 1993 |
Blechman JM, Lev S, Givol D, Yarden Y.. Structure-function analyses of the kit receptor for the steel factor. Stem Cells.. 12-21. PMID 7691317 DOI: 10.1002/stem.5530110804 |
0.755 |
|
| 1993 |
Blechman JM, Lev S, Givol D, Yarden Y. Structure-function analyses of the Kit receptor for the steel factor Stem Cells. 11: 12-21. PMID 7691317 DOI: 10.1002/Stem.5530110804 |
0.623 |
|
| 1993 |
Lev S, Blechman J, Nishikawa S, Givol D, Yarden Y.. Interspecies molecular chimeras of kit help define the binding site of the stem cell factor. Mol Cell Biol.. 13: 2224-34.. PMID 7681144 DOI: 10.1128/mcb.13.4.2224 |
0.731 |
|
| 1992 |
Lev S, Yarden Y, Givol D. Dimerization and activation of the kit receptor by monovalent and bivalent binding of the stem cell factor Journal of Biological Chemistry. 267: 15970-15977. PMID 1379243 |
0.624 |
|
| 1992 |
Lev S, Yarden Y, Givol D. A recombinant ectodomain of the receptor for the Stem Cell Factor (SCF) retains ligand-induced receptor dimerization and antagonizes SCF-stimulated cellular responses Journal of Biological Chemistry. 267: 10866-10873. PMID 1375232 |
0.63 |
|
| 1992 |
Lev S, Givol D, Yarden Y. Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase Proceedings of the National Academy of Sciences of the United States of America. 89: 678-682. PMID 1370584 DOI: 10.1073/Pnas.89.2.678 |
0.648 |
|
| 1992 |
Lev S, Givol D, Yarden Y.. Interkinase domain of kit contains the binding site for phosphatidylinositol 3' kinase. Proc Natl Acad Sci U S a.. 89: 678-82. PMID 1370584 DOI: 10.1073/pnas.89.2.678 |
0.771 |
|
| 1991 |
Lev S, Givol D, Yarden Y. A specific combination of substrates is involved in signal transduction by the kit-encoded receptor Embo Journal. 10: 647-654. PMID 1705885 DOI: 10.1002/J.1460-2075.1991.Tb07993.X |
0.77 |
|
| 1990 |
Lev S, Yarden Y, Givol D.. Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene. Mol Cell Biol.. 10: 6064-8.. PMID 1700279 DOI: 10.1128/mcb.10.11.6064 |
0.762 |
|
| 1990 |
Lev S, Yarden Y, Givol D. Receptor functions and ligand-dependent transforming potential of a chimeric kit proto-oncogene Molecular and Cellular Biology. 10: 6064-6068. PMID 1700279 DOI: 10.1128/Mcb.10.11.6064 |
0.632 |
|
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