Steven L. Reiner - Publications

Affiliations: 
Cell and Molecular Biology University of Pennsylvania, Philadelphia, PA, United States 
Area:
Cell Biology, Immunology, Human Development

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wang PH, Washburn RS, Mariuzza DL, Lin WW, Gill AL, Ahmed R, Reiner SL. Reciprocal transmission of activating and inhibitory signals and cell fate in regenerating T cells. Cell Reports. 42: 113155. PMID 37756164 DOI: 10.1016/j.celrep.2023.113155  0.549
2023 Gill AL, Wang PH, Lee J, Hudson WH, Ando S, Araki K, Hu Y, Wieland A, Im S, Gavora A, Medina CB, Freeman GJ, Hashimoto M, Reiner SL, Ahmed R. PD-1 blockade increases the self-renewal of stem-like CD8 T cells to compensate for their accelerated differentiation into effectors. Science Immunology. 8: eadg0539. PMID 37624909 DOI: 10.1126/sciimmunol.adg0539  0.426
2023 Ho P, Melms JC, Rogava M, Frangieh CJ, Poźniak J, Shah SB, Walsh Z, Kyrysyuk O, Amin AD, Caprio L, Fullerton BT, Soni RK, Ager CR, Biermann J, Wang Y, ... ... Reiner SL, et al. The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity. Cancer Cell. PMID 37327789 DOI: 10.1016/j.ccell.2023.05.014  0.341
2022 Bukhari S, Henick BS, Winchester RJ, Lerrer S, Adam K, Gartshteyn Y, Maniar R, Lin Z, Khodadadi-Jamayran A, Tsirigos A, Salvatore MM, Lagos GG, Reiner SL, Dallos MC, Mathew M, et al. Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors. Cell Reports. Medicine. 100868. PMID 36513074 DOI: 10.1016/j.xcrm.2022.100868  0.517
2022 Maniar R, Wang PH, Washburn RS, Kratchmarov R, Coley SM, Saqi A, Pan SS, Hu J, Shu CA, Rizvi NA, Henick BS, Reiner SL. Self-Renewing CD8+ T-Cell Abundance in Blood Associates with Response to Immunotherapy. Cancer Immunology Research. PMID 36512052 DOI: 10.1158/2326-6066.CIR-22-0524  0.56
2022 Wang PH, Washburn R, Maniar R, Mu M, Ringham O, Kratchmarov R, Henick BS, Reiner SL. Cutting Edge: Promoting T Cell Factor 1 T Cell Self-Renewal to Improve Programmed Cell Death Protein 1 Blockade. Journal of Immunology (Baltimore, Md. : 1950). PMID 35905999 DOI: 10.4049/jimmunol.2200317  0.444
2021 Reiner SL. A Regenerative Perspective on Successful and Failed T-Cell Immunity. Cold Spring Harbor Perspectives in Biology. PMID 33558365 DOI: 10.1101/cshperspect.a037937  0.507
2021 Johnnidis JB, Muroyama Y, Ngiow SF, Chen Z, Manne S, Cai Z, Song S, Platt JM, Schenkel JM, Abdel-Hakeem M, Beltra JC, Greenplate AR, Ali MA, Nzingha K, Giles JR, ... ... Reiner SL, et al. Inhibitory signaling sustains a distinct early memory CD8 T cell precursor that is resistant to DNA damage. Science Immunology. 6. PMID 33452106 DOI: 10.1126/sciimmunol.abe3702  0.536
2018 Kumar BV, Kratchmarov R, Miron M, Carpenter DJ, Senda T, Lerner H, Friedman A, Reiner SL, Farber DL. Functional heterogeneity of human tissue-resident memory T cells based on dye efflux capacities. Jci Insight. 3. PMID 30429372 DOI: 10.1172/Jci.Insight.123568  0.488
2018 Fang D, Cui K, Mao K, Hu G, Li R, Zheng M, Riteau N, Reiner SL, Sher A, Zhao K, Zhu J. Transient T-bet expression functionally specifies a distinct T follicular helper subset. The Journal of Experimental Medicine. PMID 30232200 DOI: 10.1084/Jem.20180927  0.638
2018 Kratchmarov R, Magun AM, Reiner SL. TCF1 expression marks self-renewing human CD8 T cells. Blood Advances. 2: 1685-1690. PMID 30021780 DOI: 10.1182/Bloodadvances.2018016279  0.623
2018 Yen B, Fortson KT, Rothman NJ, Arpaia N, Reiner SL. Clonal Bifurcation of Foxp3 Expression Visualized in Thymocytes and T Cells. Immunohorizons. 2: 119-128. PMID 29707696 DOI: 10.4049/immunohorizons.1700064  0.579
2018 Kratchmarov R, Viragova S, Kim MJ, Rothman NJ, Liu K, Reizis B, Reiner SL. Metabolic control of cell fate bifurcations in a hematopoietic progenitor population. Immunology and Cell Biology. PMID 29570858 DOI: 10.1111/Imcb.12040  0.434
2018 Madera S, Geary CD, Lau CM, Pikovskaya O, Reiner SL, Sun JC. Divergent Requirement of T-Box Transcription Factors in Effector and Memory NK Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29440505 DOI: 10.4049/Jimmunol.1700416  0.642
2018 Reiner SL. Securing front-line T cell defense. Immunology and Cell Biology. PMID 29427338 DOI: 10.1111/Imcb.12013  0.501
2018 Chen YH, Kratchmarov R, Lin WW, Rothman NJ, Yen B, Adams WC, Nish SA, Rathmell JC, Reiner SL. Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Reports. 22: 860-868. PMID 29420173 DOI: 10.1016/J.Celrep.2017.12.087  0.375
2018 Mittal P, Abblett R, Ryan JM, Hagymasi AT, Agyekum-Yamoah A, Svedova J, Reiner SL, St Rose MC, Hanley MP, Vella AT, Adler AJ. An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 29305435 DOI: 10.4049/Jimmunol.1701039  0.51
2017 Kratchmarov R, Nish SA, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Klein U, Reiner SL. IRF4 Couples Anabolic Metabolism to Th1 Cell Fate Determination. Immunohorizons. 1: 156-161. PMID 28944344 DOI: 10.4049/immunohorizons.1700012  0.576
2017 Nish SA, Lin WW, Reiner SL. Lymphocyte Fate and Metabolism: A Clonal Balancing Act. Trends in Cell Biology. PMID 28818395 DOI: 10.1016/J.Tcb.2017.07.005  0.407
2017 Collins A, Rothman N, Liu K, Reiner SL. Eomesodermin and T-bet mark developmentally distinct human natural killer cells. Jci Insight. 2: e90063. PMID 28289707 DOI: 10.1172/Jci.Insight.90063  0.564
2016 Adams WC, Chen YH, Kratchmarov R, Yen B, Nish SA, Lin WW, Rothman NJ, Luchsinger LL, Klein U, Busslinger M, Rathmell JC, Snoeck HW, Reiner SL. Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. Cell Reports. 17: 3142-3152. PMID 28009285 DOI: 10.1016/J.Celrep.2016.11.065  0.347
2016 Nish SA, Zens KD, Kratchmarov R, Lin WW, Adams WC, Chen YH, Yen B, Rothman NJ, Bhandoola A, Xue HH, Farber DL, Reiner SL. CD4+ T cell effector commitment coupled to self-renewal by asymmetric cell divisions. The Journal of Experimental Medicine. PMID 27923906 DOI: 10.1084/Jem.20161046  0.622
2016 Lin WW, Nish SA, Yen B, Chen YH, Adams WC, Kratchmarov R, Rothman NJ, Bhandoola A, Xue HH, Reiner SL. CD8(+) T Lymphocyte Self-Renewal during Effector Cell Determination. Cell Reports. 17: 1773-1782. PMID 27829149 DOI: 10.1016/J.Celrep.2016.10.032  0.577
2016 Barnett BE, Staupe RP, Odorizzi PM, Palko O, Tomov VT, Mahan AE, Gunn B, Chen D, Paley MA, Alter G, Reiner SL, Lauer GM, Teijaro JR, Wherry EJ. Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 27430722 DOI: 10.4049/Jimmunol.1500368  0.793
2016 Lau CM, Nish SA, Yogev N, Waisman A, Reiner SL, Reizis B. Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T cell responses. The Journal of Experimental Medicine. PMID 26903243 DOI: 10.1084/Jem.20150642  0.615
2016 Pikovskaya O, Chaix J, Rothman NJ, Collins A, Chen YH, Scipioni AM, Vivier E, Reiner SL. Cutting Edge: Eomesodermin Is Sufficient To Direct Type 1 Innate Lymphocyte Development into the Conventional NK Lineage. Journal of Immunology (Baltimore, Md. : 1950). PMID 26792802 DOI: 10.4049/Jimmunol.1502396  0.508
2015 Lin WW, Adams WC, Nish SA, Chen YH, Yen B, Rothman NJ, Kratchmarov R, Okada T, Klein U, Reiner SL. Asymmetric PI3K Signaling Driving Developmental and Regenerative Cell Fate Bifurcation. Cell Reports. PMID 26628372 DOI: 10.1016/J.Celrep.2015.10.072  0.496
2015 Reiner SL. T-bet transcendent: unmasking the faces of multifarious immunity. Journal of Immunology (Baltimore, Md. : 1950). 194: 2959-60. PMID 25795786 DOI: 10.4049/Jimmunol.1500289  0.411
2015 Harms Pritchard G, Hall AO, Christian DA, Wagage S, Fang Q, Muallem G, John B, Glatman Zaretsky A, Dunn WG, Perrigoue J, Reiner SL, Hunter CA. Diverse roles for T-bet in the effector responses required for resistance to infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 1131-40. PMID 25556247 DOI: 10.4049/Jimmunol.1401617  0.612
2014 Reiner SL, Adams WC. Lymphocyte fate specification as a deterministic but highly plastic process. Nature Reviews. Immunology. 14: 699-704. PMID 25190286 DOI: 10.1038/Nri3734  0.439
2014 Chaix J, Nish SA, Lin WH, Rothman NJ, Ding L, Wherry EJ, Reiner SL. Cutting edge: CXCR4 is critical for CD8+ memory T cell homeostatic self-renewal but not rechallenge self-renewal. Journal of Immunology (Baltimore, Md. : 1950). 193: 1013-6. PMID 24973450 DOI: 10.4049/Jimmunol.1400488  0.586
2013 Curran MA, Geiger TL, Montalvo W, Kim M, Reiner SL, Al-Shamkhani A, Sun JC, Allison JP. Systemic 4-1BB activation induces a novel T cell phenotype driven by high expression of Eomesodermin. The Journal of Experimental Medicine. 210: 743-55. PMID 23547098 DOI: 10.1084/Jem.20121190  0.683
2013 Hodge RD, Garcia AJ, Elsen GE, Nelson BR, Mussar KE, Reiner SL, Ramirez JM, Hevner RF. Tbr2 expression in Cajal-Retzius cells and intermediate neuronal progenitors is required for morphogenesis of the dentate gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4165-80. PMID 23447624 DOI: 10.1523/Jneurosci.4185-12.2013  0.402
2013 Paley MA, Gordon SM, Bikoff EK, Robertson EJ, Wherry EJ, Reiner SL. Technical Advance: Fluorescent reporter reveals insights into eomesodermin biology in cytotoxic lymphocytes. Journal of Leukocyte Biology. 93: 307-15. PMID 23192430 DOI: 10.1189/jlb.0812400  0.535
2013 Du Rocher B, Smith OM, Intlekofer AM, Dudakov JA, Levy E, Kreiners F, Reiner S, Abdelhay E, van den Brink MR, Hanash AM. Eomesodermin Regulates The Early Activation Of Alloreactive CD4 T Cells and Is Critical For Both Gvh and GVL Responses Blood. 122: 133-133. DOI: 10.1182/Blood.V122.21.133.133  0.811
2012 Paley MA, Kroy DC, Odorizzi PM, Johnnidis JB, Dolfi DV, Barnett BE, Bikoff EK, Robertson EJ, Lauer GM, Reiner SL, Wherry EJ. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science (New York, N.Y.). 338: 1220-5. PMID 23197535 DOI: 10.1126/Science.1229620  0.798
2012 Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, ... ... Reiner SL, et al. The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity. 37: 511-23. PMID 22981537 DOI: 10.1016/j.immuni.2012.06.014  0.485
2012 Wang NS, McHeyzer-Williams LJ, Okitsu SL, Burris TP, Reiner SL, McHeyzer-Williams MG. Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα. Nature Immunology. 13: 604-11. PMID 22561605 DOI: 10.1038/Ni.2294  0.52
2012 Hodge RD, Nelson BR, Kahoud RJ, Yang R, Mussar KE, Reiner SL, Hevner RF. Tbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 6275-87. PMID 22553033 DOI: 10.1523/Jneurosci.0532-12.2012  0.335
2012 Ciocca ML, Barnett BE, Burkhardt JK, Chang JT, Reiner SL. Cutting edge: Asymmetric memory T cell division in response to rechallenge. Journal of Immunology (Baltimore, Md. : 1950). 188: 4145-8. PMID 22467651 DOI: 10.4049/Jimmunol.1200176  0.84
2012 Gordon SM, Chaix J, Rupp LJ, Wu J, Madera S, Sun JC, Lindsten T, Reiner SL. The transcription factors T-bet and Eomes control key checkpoints of natural killer cell maturation. Immunity. 36: 55-67. PMID 22261438 DOI: 10.1016/J.Immuni.2011.11.016  0.571
2012 Barnett BE, Ciocca ML, Goenka R, Barnett LG, Wu J, Laufer TM, Burkhardt JK, Cancro MP, Reiner SL. Asymmetric B cell division in the germinal center reaction. Science (New York, N.Y.). 335: 342-4. PMID 22174128 DOI: 10.1126/Science.1213495  0.781
2011 Qui HZ, Hagymasi AT, Bandyopadhyay S, St Rose MC, Ramanarasimhaiah R, Ménoret A, Mittler RS, Gordon SM, Reiner SL, Vella AT, Adler AJ. CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation. Journal of Immunology (Baltimore, Md. : 1950). 187: 3555-64. PMID 21880986 DOI: 10.4049/Jimmunol.1101244  0.532
2011 Kao C, Oestreich KJ, Paley MA, Crawford A, Angelosanto JM, Ali MA, Intlekofer AM, Boss JM, Reiner SL, Weinmann AS, Wherry EJ. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nature Immunology. 12: 663-71. PMID 21623380 DOI: 10.1038/Ni.2046  0.786
2011 Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, ... ... Reiner SL, et al. Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity. 34: 492-504. PMID 21497118 DOI: 10.1016/J.Immuni.2011.03.017  0.839
2011 Gordon SM, Carty SA, Kim JS, Zou T, Smith-Garvin J, Alonzo ES, Haimm E, Sant'Angelo DB, Koretzky GA, Reiner SL, Jordan MS. Requirements for eomesodermin and promyelocytic leukemia zinc finger in the development of innate-like CD8+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 186: 4573-8. PMID 21383242 DOI: 10.4049/Jimmunol.1100037  0.591
2010 Kinjyo I, Gordon SM, Intlekofer AM, Dowdell K, Mooney EC, Caricchio R, Grupp SA, Teachey DT, Rao VK, Lindsten T, Reiner SL. Cutting edge: Lymphoproliferation caused by Fas deficiency is dependent on the transcription factor eomesodermin. Journal of Immunology (Baltimore, Md. : 1950). 185: 7151-5. PMID 21076068 DOI: 10.4049/Jimmunol.1003193  0.815
2010 Banerjee A, Gordon SM, Intlekofer AM, Paley MA, Mooney EC, Lindsten T, Wherry EJ, Reiner SL. Cutting edge: The transcription factor eomesodermin enables CD8+ T cells to compete for the memory cell niche. Journal of Immunology (Baltimore, Md. : 1950). 185: 4988-92. PMID 20935204 DOI: 10.4049/Jimmunol.1002042  0.809
2010 Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, ... ... Reiner SL, et al. Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms. Journal of Immunology (Baltimore, Md. : 1950). 185: 367-75. PMID 20530266 DOI: 10.4049/Jimmunol.0903627  0.629
2010 Banerjee A, Schambach F, DeJong CS, Hammond SM, Reiner SL. Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. European Journal of Immunology. 40: 225-31. PMID 19877012 DOI: 10.1002/Eji.200939381  0.476
2009 Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, et al. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. The Journal of Experimental Medicine. 206: 2469-81. PMID 19808259 DOI: 10.1084/Jem.20090525  0.459
2009 Ahmed R, Bevan MJ, Reiner SL, Fearon DT. The precursors of memory: models and controversies. Nature Reviews. Immunology. 9: 662-8. PMID 19680250 DOI: 10.1038/Nri2619  0.545
2009 Shin H, Blackburn SD, Intlekofer AM, Kao C, Angelosanto JM, Reiner SL, Wherry EJ. A role for the transcriptional repressor Blimp-1 in CD8(+) T cell exhaustion during chronic viral infection. Immunity. 31: 309-20. PMID 19664943 DOI: 10.1016/J.Immuni.2009.06.019  0.795
2009 Weinreich MA, Takada K, Skon C, Reiner SL, Jameson SC, Hogquist KA. KLF2 transcription-factor deficiency in T cells results in unrestrained cytokine production and upregulation of bystander chemokine receptors. Immunity. 31: 122-30. PMID 19592277 DOI: 10.1016/J.Immuni.2009.05.011  0.61
2009 Kambayashi T, Allenspach EJ, Chang JT, Zou T, Shoag JE, Reiner SL, Caton AJ, Koretzky GA. Inducible MHC class II expression by mast cells supports effector and regulatory T cell activation. Journal of Immunology (Baltimore, Md. : 1950). 182: 4686-95. PMID 19342644 DOI: 10.4049/Jimmunol.0803180  0.563
2009 Hegel JK, Knieke K, Kolar P, Reiner SL, Brunner-Weinzierl MC. CD152 (CTLA-4) regulates effector functions of CD8+ T lymphocytes by repressing Eomesodermin. European Journal of Immunology. 39: 883-93. PMID 19224637 DOI: 10.1002/Eji.200838770  0.553
2009 Reiner SL. Decision making during the conception and career of CD4+ T cells. Nature Reviews. Immunology. 9: 81-2. PMID 19172726 DOI: 10.1038/Nri2490  0.607
2009 Debes GF, Reiner SL. Helping and harming have something in common. Nature Immunology. 10: 138-40. PMID 19148197 DOI: 10.1038/Ni0209-138  0.673
2009 Banerjee A, Gordon SM, Intlekofer AM, Wherry EJ, Reiner SL. Defective Central Memory CD8+ T Cell Differentiation in the Absence of Eomesodermin. Blood. 114: 2662-2662. DOI: 10.1182/Blood.V114.22.2662.2662  0.804
2008 Mrass P, Kinjyo I, Ng LG, Reiner SL, Puré E, Weninger W. CD44 mediates successful interstitial navigation by killer T cells and enables efficient antitumor immunity. Immunity. 29: 971-85. PMID 19100702 DOI: 10.1016/J.Immuni.2008.10.015  0.616
2008 Chang JT, Reiner SL. Asymmetric division and stem cell renewal without a permanent niche: Lessons from lymphocytes Cold Spring Harbor Symposia On Quantitative Biology. 73: 73-79. PMID 19022740 DOI: 10.1101/Sqb.2008.73.008  0.476
2008 Reiner SL. Inducing the T cell fates required for immunity. Immunologic Research. 42: 160-5. PMID 18806935 DOI: 10.1007/S12026-008-8054-9  0.635
2008 Intlekofer AM, Banerjee A, Takemoto N, Gordon SM, Dejong CS, Shin H, Hunter CA, Wherry EJ, Lindsten T, Reiner SL. Anomalous type 17 response to viral infection by CD8+ T cells lacking T-bet and eomesodermin. Science (New York, N.Y.). 321: 408-11. PMID 18635804 DOI: 10.1126/Science.1159806  0.815
2008 Chang JT, Reiner SL. Specifying helper T cell fates during immunity. Journal of Pediatric Gastroenterology and Nutrition. 46: E19-20. PMID 18354322 DOI: 10.1097/01.Mpg.0000313832.47207.0E  0.6
2008 Ng LG, Mrass P, Kinjyo I, Reiner SL, Weninger W. Two-photon imaging of effector T-cell behavior: lessons from a tumor model. Immunological Reviews. 221: 147-62. PMID 18275480 DOI: 10.1111/J.1600-065X.2008.00596.X  0.561
2007 Chang JT, Reiner SL. Protection one cell thick. Immunity. 27: 832-4. PMID 18093536 DOI: 10.1016/J.Immuni.2007.11.009  0.325
2007 Wei J, Duramad O, Perng OA, Reiner SL, Liu YJ, Qin FX. Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 18169-74. PMID 17978190 DOI: 10.1073/Pnas.0703642104  0.622
2007 Intlekofer AM, Takemoto N, Kao C, Banerjee A, Schambach F, Northrop JK, Shen H, Wherry EJ, Reiner SL. Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells. The Journal of Experimental Medicine. 204: 2015-21. PMID 17698591 DOI: 10.1084/Jem.20070841  0.804
2007 Schambach F, Schupp M, Lazar MA, Reiner SL. Activation of retinoic acid receptor-alpha favours regulatory T cell induction at the expense of IL-17-secreting T helper cell differentiation. European Journal of Immunology. 37: 2396-9. PMID 17694576 DOI: 10.1002/Eji.200737621  0.58
2007 Reiner SL, Sallusto F, Lanzavecchia A. Division of labor with a workforce of one: challenges in specifying effector and memory T cell fate. Science (New York, N.Y.). 317: 622-5. PMID 17673652 DOI: 10.1126/Science.1143775  0.62
2007 Reiner SL. Development in motion: helper T cells at work. Cell. 129: 33-6. PMID 17418783 DOI: 10.1016/J.Cell.2007.03.019  0.582
2007 Chang JT, Palanivel VR, Kinjyo I, Schambach F, Intlekofer AM, Banerjee A, Longworth SA, Vinup KE, Mrass P, Oliaro J, Killeen N, Orange JS, Russell SM, Weninger W, Reiner SL. Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science (New York, N.Y.). 315: 1687-91. PMID 17332376 DOI: 10.1126/Science.1139393  0.859
2007 Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-gamma production by gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 2730-6. PMID 17312115 DOI: 10.4049/Jimmunol.178.5.2730  0.816
2007 Jenkinson SR, Intlekofer AM, Sun G, Feigenbaum L, Reiner SL, Bosselut R. Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation. The Journal of Experimental Medicine. 204: 267-72. PMID 17296789 DOI: 10.1084/Jem.20061982  0.754
2007 Chen L, He W, Kim ST, Tao J, Gao Y, Chi H, Intlekofer AM, Harvey B, Reiner SL, Yin Z, Flavell RA, Craft J. Epigenetic and transcriptional programs lead to default IFN-γ production by γδ T cells The Journal of Immunology. 178: 5401.2-5401. DOI: 10.4049/jimmunol.178.8.5401-a  0.718
2007 Banerjee A, Reiner S. The Significance of MicroRNA-155 in Lymphocytic Malignancy. Blood. 110: 4166-4166. DOI: 10.1182/Blood.V110.11.4166.4166  0.321
2006 Takemoto N, Intlekofer AM, Northrup JT, Wherry EJ, Reiner SL. Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiation. Journal of Immunology (Baltimore, Md. : 1950). 177: 7515-9. PMID 17114419 DOI: 10.4049/Jimmunol.177.11.7515  0.81
2006 Suto A, Wurster AL, Reiner SL, Grusby MJ. IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. Journal of Immunology (Baltimore, Md. : 1950). 177: 3721-7. PMID 16951332 DOI: 10.4049/Jimmunol.177.6.3721  0.512
2006 Atherly LO, Lucas JA, Felices M, Yin CC, Reiner SL, Berg LJ. The Tec family tyrosine kinases Itk and Rlk regulate the development of conventional CD8+ T cells. Immunity. 25: 79-91. PMID 16860759 DOI: 10.1016/J.Immuni.2006.05.012  0.611
2006 Intlekofer AM, Wherry EJ, Reiner SL. Not-so-great expectations: re-assessing the essence of T-cell memory. Immunological Reviews. 211: 203-13. PMID 16824129 DOI: 10.1111/J.0105-2896.2006.00396.X  0.756
2006 Gray PM, Reiner SL, Smith DF, Kaye PM, Scott P. Antigen-experienced T cells limit the priming of naive T cells during infection with Leishmania major. Journal of Immunology (Baltimore, Md. : 1950). 177: 925-33. PMID 16818747 DOI: 10.4049/Jimmunol.177.2.925  0.591
2006 Long M, Slaiby AM, Hagymasi AT, Mihalyo MA, Lichtler AC, Reiner SL, Adler AJ. T-bet down-modulation in tolerized Th1 effector CD4 cells confers a TCR-distal signaling defect that selectively impairs IFN-gamma expression. Journal of Immunology (Baltimore, Md. : 1950). 176: 1036-45. PMID 16393991 DOI: 10.1182/Blood.V106.11.3321.3321  0.526
2006 Banerjee A, Schambach F, Hammond S, Reiner S. Micro-RNA Profiling in CD4+ T Cell Differentiation. Blood. 108: 3887-3887. DOI: 10.1182/Blood.V108.11.3887.3887  0.566
2006 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, ... ... Reiner SL, et al. Erratum: Corrigendum: Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin Nature Immunology. 7: 113-113. DOI: 10.1038/Ni0106-113  0.806
2005 Intlekofer AM, Takemoto N, Wherry EJ, Longworth SA, Northrup JT, Palanivel VR, Mullen AC, Gasink CR, Kaech SM, Miller JD, Gapin L, Ryan K, Russ AP, Lindsten T, Orange JS, ... ... Reiner SL, et al. Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin. Nature Immunology. 6: 1236-44. PMID 16273099 DOI: 10.1038/Ni1268  0.844
2005 Martins GA, Hutchins AS, Reiner SL. Transcriptional activators of helper T cell fate are required for establishment but not maintenance of signature cytokine expression. Journal of Immunology (Baltimore, Md. : 1950). 175: 5981-5. PMID 16237092 DOI: 10.4049/Jimmunol.175.9.5981  0.863
2005 Hutchins AS, Artis D, Hendrich BD, Bird AP, Scott P, Reiner SL. Cutting edge: a critical role for gene silencing in preventing excessive type 1 immunity. Journal of Immunology (Baltimore, Md. : 1950). 175: 5606-10. PMID 16237047 DOI: 10.4049/Jimmunol.175.9.5606  0.844
2005 Reiner SL. Epigenetic control in the immune response. Human Molecular Genetics. 14: R41-6. PMID 15809272 DOI: 10.1093/Hmg/Ddi115  0.586
2005 Sallusto F, Reiner SL. Sliding doors in the immune response. Nature Immunology. 6: 10-2. PMID 15611774 DOI: 10.1038/Ni0105-10  0.448
2004 Hewitt SL, High FA, Reiner SL, Fisher AG, Merkenschlager M. Nuclear repositioning marks the selective exclusion of lineage-inappropriate transcription factor loci during T helper cell differentiation. European Journal of Immunology. 34: 3604-13. PMID 15484194 DOI: 10.1002/Eji.200425469  0.52
2004 Anfossi N, Robbins SH, Ugolini S, Georgel P, Hoebe K, Bouneaud C, Ronet C, Kaser A, DiCioccio CB, Tomasello E, Blumberg RS, Beutler B, Reiner SL, Alexopoulou L, Lantz O, et al. Expansion and function of CD8+ T cells expressing Ly49 inhibitory receptors specific for MHC class I molecules. Journal of Immunology (Baltimore, Md. : 1950). 173: 3773-82. PMID 15356124 DOI: 10.4049/Jimmunol.173.6.3773  0.627
2004 Tato CM, Martins GA, High FA, DiCioccio CB, Reiner SL, Hunter CA. Cutting Edge: Innate production of IFN-gamma by NK cells is independent of epigenetic modification of the IFN-gamma promoter. Journal of Immunology (Baltimore, Md. : 1950). 173: 1514-7. PMID 15265878 DOI: 10.4049/Jimmunol.173.3.1514  0.493
2004 Lieberman LA, Banica M, Reiner SL, Hunter CA. STAT1 plays a critical role in the regulation of antimicrobial effector mechanisms, but not in the development of Th1-type responses during toxoplasmosis. Journal of Immunology (Baltimore, Md. : 1950). 172: 457-63. PMID 14688355 DOI: 10.4049/Jimmunol.172.1.457  0.543
2003 Reiner SL. Immunity and the animation of the genome. Immunity. 19: 775-80. PMID 14670295 DOI: 10.1016/S1074-7613(03)00333-9  0.395
2003 Pearce EL, Mullen AC, Martins GA, Krawczyk CM, Hutchins AS, Zediak VP, Banica M, DiCioccio CB, Gross DA, Mao CA, Shen H, Cereb N, Yang SY, Lindsten T, Rossant J, ... ... Reiner SL, et al. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Science (New York, N.Y.). 302: 1041-3. PMID 14605368 DOI: 10.1126/Science.1090148  0.86
2003 Reiner SL, Mullen AC, Hutchins AS, Pearce EL. Helper T cell differentiation and the problem of cellular inheritance. Immunologic Research. 27: 463-8. PMID 12857989 DOI: 10.1385/Ir:27:2-3:463  0.843
2002 Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nature Reviews. Immunology. 2: 933-44. PMID 12461566 DOI: 10.1038/Nri954  0.635
2002 Hutchins AS, Mullen AC, Lee HW, Sykes KJ, High FA, Hendrich BD, Bird AP, Reiner SL. Gene silencing quantitatively controls the function of a developmental trans-activator. Molecular Cell. 10: 81-91. PMID 12150909 DOI: 10.1016/S1097-2765(02)00564-6  0.806
2002 Mullen AC, Hutchins AS, High FA, Lee HW, Sykes KJ, Chodosh LA, Reiner SL. Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction. Nature Immunology. 3: 652-8. PMID 12055627 DOI: 10.1038/Ni807  0.842
2001 Mullen AC, Hutchins AS, Villarino AV, Lee HW, High FA, Cereb N, Yang SY, Hua X, Reiner SL. Cell cycle controlling the silencing and functioning of mammalian activators. Current Biology : Cb. 11: 1695-9. PMID 11696328 DOI: 10.1016/S0960-9822(01)00533-4  0.858
2001 Doyle AM, Mullen AC, Villarino AV, Hutchins AS, High FA, Lee HW, Thompson CB, Reiner SL. Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells. The Journal of Experimental Medicine. 194: 893-902. PMID 11581312 DOI: 10.1084/Jem.194.7.893  0.873
2001 Reiner SL. Helper T cell differentiation, inside and out Current Opinion in Immunology. 13: 351-355. PMID 11406368 DOI: 10.1016/S0952-7915(00)00226-0  0.55
2001 Mullen AC, High FA, Hutchins AS, Lee HW, Villarino AV, Livingston DM, Kung AL, Cereb N, Yao TP, Yang SY, Reiner SL. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science (New York, N.Y.). 292: 1907-10. PMID 11397944 DOI: 10.1126/Science.1059835  0.822
2000 Hunter CA, Reiner SL. Cytokines and T cells in host defense Current Opinion in Immunology. 12: 413-418. PMID 10899023 DOI: 10.1016/S0952-7915(00)00110-2  0.566
2000 Masteller EL, Chuang E, Mullen AC, Reiner SL, Thompson CB. Structural analysis of CTLA-4 function in vivo. Journal of Immunology (Baltimore, Md. : 1950). 164: 5319-27. PMID 10799894 DOI: 10.4049/Jimmunol.164.10.5319  0.737
2000 Finkelman FD, Morris SC, Orekhova T, Mori M, Donaldson D, Reiner SL, Reilly NL, Schopf L, Urban JF. Stat6 regulation of in vivo IL-4 responses Journal of Immunology. 164: 2303-2310. PMID 10679064 DOI: 10.4049/Jimmunol.164.5.2303  0.455
1999 Pippig SD, Peña-Rossi C, Long J, Godfrey WR, Fowell DJ, Reiner SL, Birkeland ML, Locksley RM, Barclay AN, Killeen N. Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40). Journal of Immunology (Baltimore, Md. : 1950). 163: 6520-9. PMID 10586044  0.548
1999 Reiner SL, Seder RA. Dealing from the evolutionary pawnshop: How lymphocytes make decisions Immunity. 11: 1-10. PMID 10435574 DOI: 10.1016/S1074-7613(00)80076-X  0.398
1999 Coffman RL, Reiner SL. Instruction, selection, or tampering with the odds? Science. 284: 1283-1285. PMID 10383307 DOI: 10.1126/Science.284.5418.1283  0.573
1999 Brown CR, Reiner SL. Experimental lyme arthritis in the absence of interleukin-4 or gamma interferon. Infection and Immunity. 67: 3329-33. PMID 10377109 DOI: 10.1128/Iai.67.7.3329-3333.1999  0.314
1999 Brown CR, Reiner SL. Genetic control of experimental lyme arthritis in the absence of specific immunity. Infection and Immunity. 67: 1967-73. PMID 10085044 DOI: 10.1128/Iai.67.4.1967-1973.1999  0.308
1999 Brown DR, Reiner SL. Polarized helper-T-cell responses against Leishmania major in the absence of B cells Infection and Immunity. 67: 266-270. PMID 9864225 DOI: 10.1128/Iai.67.1.266-270.1999  0.492
1998 Brown CR, Reiner SL. Activation of natural killer cells in arthritis-susceptible but not arthritis-resistant mouse strains following Borrelia burgdorferi infection. Infection and Immunity. 66: 5208-14. PMID 9784524 DOI: 10.1128/Iai.66.11.5208-5214.1998  0.392
1998 Noel PJ, Alegre ML, Reiner SL, Thompson CB. Impaired negative selection in CD28-deficient mice Cellular Immunology. 187: 131-138. PMID 9732701 DOI: 10.1006/Cimm.1998.1332  0.547
1998 Bird JJ, Brown DR, Mullen AC, Moskowitz NH, Mahowald MA, Sider JR, Gajewski TF, Wang CR, Reiner SL. Helper T cell differentiation is controlled by the cell cycle. Immunity. 9: 229-37. PMID 9729043 DOI: 10.1016/S1074-7613(00)80605-6  0.797
1998 Reiner SL, Fowell DJ, Moskowitz NH, Swier K, Brown DR, Brown CR, Turck CW, Scott PA, Killeen N, Locksley RM. Control of Leishmania major by a monoclonal alpha beta T cell repertoire. Journal of Immunology (Baltimore, Md. : 1950). 160: 884-9. PMID 9551925  0.373
1998 Gilffillan MC, Noel PJ, Podack ER, Reiner SL, Thompson CB. Expression of the costimulatory receptor CD30 is regulated by both CD28 and cytokines Journal of Immunology. 160: 2180-2187. PMID 9498756  0.448
1998 Khoruts A, Mondino A, Pape KA, Reiner SL, Jenkins MK. A natural immunological adjuvant enhances T cell clonal expansion through a CD28-dependent, interleukin (IL)-2-independent mechanism. The Journal of Experimental Medicine. 187: 225-36. PMID 9432980 DOI: 10.1084/Jem.187.2.225  0.603
1997 Gurunathan S, Sacks DL, Brown DR, Reiner SL, Charest H, Glaichenhaus N, Seder RA. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. The Journal of Experimental Medicine. 186: 1137-47. PMID 9314562 DOI: 10.1084/Jem.186.7.1137  0.327
1997 Brown DR, Moskowitz NH, Killeen N, Reiner SL. A role for CD4 in peripheral T cell differentiation Journal of Experimental Medicine. 186: 101-107. PMID 9207001 DOI: 10.1084/Jem.186.1.101  0.577
1997 Sato S, Reiner SL, Jensen MA, Roos RP. Central nervous system cytokine mRNA expression following Theiler's murine encephalomyelitis virus infection. Journal of Neuroimmunology. 76: 213-23. PMID 9184653 DOI: 10.1016/S0165-5728(97)00059-3  0.351
1997 Moskowitz NH, Brown DR, Reiner SL. Efficient immunity against Leishmania major in the absence of interleukin-6 Infection and Immunity. 65: 2448-2450. PMID 9169788  0.304
1997 Brown DR, Swier K, Moskowitz NH, Naujokas MF, Locksley RM, Reiner SL. T helper subset differentiation in the absence of invariant chain Journal of Experimental Medicine. 185: 31-41. PMID 8996239 DOI: 10.1084/Jem.185.1.31  0.736
1996 Brown DR, Green JM, Moskowitz NH, Davis M, Thompson CB, Reiner SL. Limited role of CD28-mediated signals in T helper subset differentiation Journal of Experimental Medicine. 184: 803-810. PMID 9064340 DOI: 10.1084/Jem.184.3.803  0.465
1996 Alegre ML, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, Thompson CB. Regulation of Surface and Intracellular Expression of CTLA4 on Mouse T Cells Journal of Immunology. 157: 4762-4770. PMID 8943377  0.412
1996 Brown DR, Fowell DJ, Corry DB, Wynn TA, Moskowitz NH, Cheever AW, Locksley RM, Reiner SL. β2-Microglobulin-dependent NK1.1+ T cells are not essential for T helper cell 2 immune responses Journal of Experimental Medicine. 184: 1295-1304. PMID 8879201 DOI: 10.1084/Jem.184.4.1295  0.714
1996 Brown DR, Kileen N, Reiner SL. Balb cd4-deficient mice default from th2 to th1 responses during murine leishmaniasis Faseb Journal. 10.  0.48
1995 Reiner SL, Locksley RM. The regulation of immunity to Leishmania major Annual Review of Immunology. 13: 151-177. PMID 7612219 DOI: 10.1146/Annurev.Iy.13.040195.001055  0.602
1995 Reiner SL, Seder RA. T helper cell differentiation in immune response Current Opinion in Immunology. 7: 360-366. PMID 7546401 DOI: 10.1016/0952-7915(95)80111-1  0.579
1995 Pearce EJ, Reiner SL. Induction of Th2 responses in infectious diseases Current Opinion in Immunology. 7: 497-504. PMID 7495513 DOI: 10.1016/0952-7915(95)80094-8  0.535
1994 Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR. J. Immunol. Methods 165 (1993) 37-46 (PII:0022-1759(93)90104-F) Journal of Immunological Methods. 173: 133. PMID 8034981 DOI: 10.1016/0022-1759(94)90291-7  0.378
1994 Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR. (J. Immunol. Methods 165 (1993) 37-46; 173 (1994) 133) (PII:0022-1759(94)00210-X) Journal of Immunological Methods. 175: 275. PMID 7930655 DOI: 10.1016/0022-1759(94)90370-0  0.382
1994 Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM. CD4+ effector cells default to the Th2 pathway in interferon γ-deficient mice infected with Leishmania major Journal of Experimental Medicine. 179: 1367-1371. PMID 7908325 DOI: 10.1084/Jem.179.4.1367  0.656
1994 Reiner SL, Zheng S, Wang ZE, Stowring L, Locksley RM. Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection Journal of Experimental Medicine. 179: 447-456. PMID 7905017 DOI: 10.1084/Jem.179.2.447  0.556
1994 Wang ZE, Zheng S, Corry DB, Dalton DK, Seder RA, Reiner SL, Locksley RM. Interferon γ-independent effects of interleukin 12 administered during acute or established infection due to Leishmania major Proceedings of the National Academy of Sciences of the United States of America. 91: 12932-12936. PMID 7809149 DOI: 10.1073/Pnas.91.26.12932  0.557
1994 Corry DB, Reiner SL, Linsley PS, Locksley RM. Differential effects of blockade of CD28-B7 on the development of Th1 or Th2 effector cells in experimental Leishmaniasis Journal of Immunology. 153: 4142-4148. PMID 7523517  0.395
1994 Reiner SL. Parasites and T helper cell development: Some insights Parasitology Today. 10: 485-488. DOI: 10.1016/0169-4758(94)90162-7  0.431
1993 Reiner SL, Wang ZE, Hatam F, Scott P, Locksley RM. TH1 and TH2 cell antigen receptors in experimental leishmaniasis Science. 259: 1457-1463. PMID 8451641 DOI: 10.1126/Science.8451641  0.607
1993 Reiner SL, Zheng S, Corry DB, Locksley RM. Constructing polycompetitor cDNAs for quantitative PCR Journal of Immunological Methods. 165: 37-46. PMID 8409467 DOI: 10.1016/0022-1759(93)90104-F  0.46
1993 Locksley RM, Reiner SL, Hatam F, Littman DR, Killeen N. Helper T cells without CD4: Control of leishmaniasis in CD4-deficient mice Science. 261: 1448-1451. PMID 8367726 DOI: 10.1126/Science.8367726  0.682
1993 Wang ZE, Reiner SL, Hatam F, Heinzel FP, Bouvier J, Turck CW, Locksley RM. Targeted activation of CD8 cells and infection of β2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental Leishmaniasis Journal of Immunology. 151: 2077-2086. PMID 8102158  0.426
1993 Tobin JF, Reiner SL, Hatam F, Zheng S, Leptak CL, Wirth DF, Locksley RM. Transfected Leishmania expressing biologically active IFN-γ Journal of Immunology. 150: 5059-5069. PMID 8098724  0.321
1993 Reiner SL, Locksley RM. Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis Journal of Cellular Biochemistry. 53: 323-328. PMID 7905485 DOI: 10.1002/Jcb.240530409  0.576
1993 Reiner SL, Locksley RM. The worm and the protozoa: Stereotyped responses or distinct antigens? Parasitology Today. 9: 258-260. DOI: 10.1016/0169-4758(93)90071-M  0.656
1992 Reiner SL, Locksley RM. Lessons from Leishmania: a model for investigations of CD4+ subset differentiation Infectious Agents and Disease. 1: 33-42. PMID 1365527  0.337
1991 Holaday BJ, Sadick MD, Wang ZE, Reiner SL, Heinzel FP, Parslow TG, Locksley RM. Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines Journal of Immunology. 147: 1653-1658. PMID 1831830  0.406
1991 Locksley RM, Heinzel FP, Holaday BJ, Mutha SS, Reiner SL, Sadick MD. Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection Research in Immunology. 142: 28-32. PMID 1829257 DOI: 10.1016/0923-2494(91)90007-6  0.503
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