Howard J. Federoff - Publications

Affiliations: 
Center for Aging and Developmental Biology University of Rochester Medical Center, Rochester, NY, United States 

206 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Heiss JD, Lungu C, Hammoud DA, Herscovitch P, Ehrlich DJ, Argersinger DP, Sinharay S, Scott G, Wu T, Federoff HJ, Zaghloul KA, Hallett M, Lonser RR, Bankiewicz KS. Trial of magnetic resonance-guided putaminal gene therapy for advanced Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31145831 DOI: 10.1002/Mds.27724  0.34
2017 Subramaniam SR, Federoff HJ. Targeting Microglial Activation States as a Therapeutic Avenue in Parkinson's Disease. Frontiers in Aging Neuroscience. 9: 176. PMID 28642697 DOI: 10.3389/Fnagi.2017.00176  0.319
2017 Su X, Fischer DL, Li X, Bankiewicz K, Sortwell CE, Federoff HJ. Alpha-Synuclein mRNA Is Not Increased. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28522034 DOI: 10.1016/J.Ymthe.2017.04.018  0.466
2015 Su X, Chu Y, Kordower JH, Li B, Cao H, Huang L, Nishida M, Song L, Wang D, Federoff HJ. PGC-1α Promoter Methylation in Parkinson's Disease. Plos One. 10: e0134087. PMID 26317511 DOI: 10.1371/Journal.Pone.0134087  0.524
2014 Gustafsson M, Nestor CE, Zhang H, Barabási AL, Baranzini S, Brunak S, Chung KF, Federoff HJ, Gavin AC, Meehan RR, Picotti P, Pujana MÀ, Rajewsky N, Smith KG, Sterk PJ, et al. Modules, networks and systems medicine for understanding disease and aiding diagnosis. Genome Medicine. 6: 82. PMID 25473422 DOI: 10.1186/S13073-014-0082-6  0.306
2014 Su X, Federoff HJ. Immune responses in Parkinson's disease: interplay between central and peripheral immune systems. Biomed Research International. 2014: 275178. PMID 24822191 DOI: 10.1155/2014/275178  0.525
2014 Fiandaca MS, Federoff HJ. Using viral-mediated gene delivery to model Parkinson's disease: do nonhuman primate investigations expand our understanding? Experimental Neurology. 256: 117-25. PMID 23524194 DOI: 10.1016/J.Expneurol.2013.03.014  0.344
2013 Huang L, Su X, Federoff HJ. Single-chain fragment variable passive immunotherapies for neurodegenerative diseases. International Journal of Molecular Sciences. 14: 19109-27. PMID 24048248 DOI: 10.3390/Ijms140919109  0.534
2013 Huang L, Shimoji M, Wang J, Shah S, Kamila S, Biehl ER, Lim S, Chang A, Maguire-Zeiss KA, Su X, Federoff HJ. Development of inducible leucine-rich repeat kinase 2 (LRRK2) cell lines for therapeutics development in Parkinson's disease. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 10: 840-51. PMID 23963789 DOI: 10.1007/S13311-013-0208-3  0.548
2013 MacArthur L, Ressom H, Shah S, Federoff HJ. Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease. Expert Review of Neurotherapeutics. 13: 685-93. PMID 23739005 DOI: 10.1586/Ern.13.59  0.304
2013 Béraud D, Hathaway HA, Trecki J, Chasovskikh S, Johnson DA, Johnson JA, Federoff HJ, Shimoji M, Mhyre TR, Maguire-Zeiss KA. Microglial activation and antioxidant responses induced by the Parkinson's disease protein α-synuclein. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 94-117. PMID 23054368 DOI: 10.1007/S11481-012-9401-0  0.322
2013 Fiandaca MS, Padilla RM, Conteh I, Federoff HJ. Can population genomics guide future therapeutic gene transfer strategies for Parkinson’s disease? Open Journal of Genetics. 3: 19-29. DOI: 10.4236/Ojgen.2013.32A1003  0.303
2012 Fiandaca MS, Bankiewicz KS, Federoff HJ. Gene therapy for the treatment of Parkinson's disease: the nature of the biologics expands the future indications. Pharmaceuticals (Basel, Switzerland). 5: 553-90. PMID 24281662 DOI: 10.3390/Ph5060553  0.307
2011 Hadaczek P, Beyer J, Kells A, Narrow W, Bowers W, Federoff HJ, Forsayeth J, Bankiewicz KS. Evaluation of an AAV2-based rapamycin-regulated glial cell line-derived neurotrophic factor (GDNF) expression vector system. Plos One. 6: e27728. PMID 22132130 DOI: 10.1371/Journal.Pone.0027728  0.576
2011 Schnell L, Hunanyan AS, Bowers WJ, Horner PJ, Federoff HJ, Gullo M, Schwab ME, Mendell LM, Arvanian VL. Combined delivery of Nogo-A antibody, neurotrophin-3 and the NMDA-NR2d subunit establishes a functional 'detour' in the hemisected spinal cord. The European Journal of Neuroscience. 34: 1256-67. PMID 21995852 DOI: 10.1111/J.1460-9568.2011.07862.X  0.548
2011 Shah S, Federoff HJ. Therapeutic potential of vaccines for Alzheimer's disease. Immunotherapy. 3: 287-98. PMID 21322764 DOI: 10.2217/Imt.10.94  0.314
2011 Philippidou P, Valdez G, Akmentin W, Bowers WJ, Federoff HJ, Halegoua S. Trk retrograde signaling requires persistent, Pincher-directed endosomes. Proceedings of the National Academy of Sciences of the United States of America. 108: 852-7. PMID 21187387 DOI: 10.1073/Pnas.1015981108  0.551
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-1481. PMID 28178507 DOI: 10.1038/mt.2010.111  0.691
2010 Zheng B, Liao Z, Locascio JJ, Lesniak KA, Roderick SS, Watt ML, Eklund AC, Zhang-James Y, Kim PD, Hauser MA, Grünblatt E, Moran LB, Mandel SA, Riederer P, Miller RM, ... Federoff HJ, et al. PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Science Translational Medicine. 2: 52ra73. PMID 20926834 DOI: 10.1126/Scitranslmed.3001059  0.36
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/Nm.2199  0.554
2010 Kells AP, Eberling J, Su X, Pivirotto P, Bringas J, Hadaczek P, Narrow WC, Bowers WJ, Federoff HJ, Forsayeth J, Bankiewicz KS. Regeneration of the MPTP-lesioned dopaminergic system after convection-enhanced delivery of AAV2-GDNF. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9567-77. PMID 20631185 DOI: 10.1523/Jneurosci.0942-10.2010  0.662
2010 Ryan DA, Mastrangelo MA, Narrow WC, Sullivan MA, Federoff HJ, Bowers WJ. Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1471-81. PMID 20551911 DOI: 10.1038/Mt.2010.111  0.711
2010 Maguire-Zeiss KA, Federoff HJ. Future directions for immune modulation in neurodegenerative disorders: focus on Parkinson's disease. Journal of Neural Transmission (Vienna, Austria : 1996). 117: 1019-25. PMID 20549523 DOI: 10.1007/S00702-010-0431-6  0.333
2010 Ryan DA, Narrow WC, Federoff HJ, Bowers WJ. An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies. Journal of Neuroscience Methods. 190: 171-9. PMID 20452375 DOI: 10.1016/J.Jneumeth.2010.05.001  0.689
2010 Halterman MW, Gill M, DeJesus C, Ogihara M, Schor NF, Federoff HJ. The endoplasmic reticulum stress response factor CHOP-10 protects against hypoxia-induced neuronal death. The Journal of Biological Chemistry. 285: 21329-40. PMID 20448044 DOI: 10.1074/Jbc.M109.095299  0.753
2010 Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. Plos One. 5: e9002. PMID 20126313 DOI: 10.1371/Journal.Pone.0009002  0.342
2010 de Silva S, Mastrangelo MA, Lotta LT, Burris CA, Federoff HJ, Bowers WJ. Extending the transposable payload limit of Sleeping Beauty (SB) using the Herpes Simplex Virus (HSV)/SB amplicon-vector platform. Gene Therapy. 17: 424-31. PMID 19865178 DOI: 10.1038/Gt.2009.144  0.711
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-2040. PMID 28178451 DOI: 10.1038/mt.2009.174  0.553
2009 Luo Y, Sarabi SA, Backman C, Shan L, Hoffer B, Federoff H. Expression pattern of NuIP gene in adult mouse brain. Brain Research. 1302: 42-53. PMID 19765553 DOI: 10.1016/J.Brainres.2009.09.026  0.529
2009 Su X, Kells AP, Huang EJ, Lee HS, Hadaczek P, Beyer J, Bringas J, Pivirotto P, Penticuff J, Eberling J, Federoff HJ, Forsayeth J, Bankiewicz KS. Safety evaluation of AAV2-GDNF gene transfer into the dopaminergic nigrostriatal pathway in aged and parkinsonian rhesus monkeys. Human Gene Therapy. 20: 1627-40. PMID 19671001 DOI: 10.1089/Hum.2009.103  0.524
2009 Sudol KL, Mastrangelo MA, Narrow WC, Frazer ME, Levites YR, Golde TE, Federoff HJ, Bowers WJ. Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 2031-40. PMID 19638957 DOI: 10.1038/Mt.2009.174  0.587
2009 Su X, Federoff HJ, Maguire-Zeiss KA. Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotoxicity Research. 16: 238-54. PMID 19526281 DOI: 10.1007/S12640-009-9053-X  0.544
2009 Federoff HJ. Nur(R1)turing a notion on the etiopathogenesis of Parkinson's disease. Neurotoxicity Research. 16: 261-70. PMID 19526279 DOI: 10.1007/S12640-009-9056-7  0.324
2009 Federoff HJ. Development of vaccination approaches for the treatment of neurological diseases. The Journal of Comparative Neurology. 515: 4-14. PMID 19399901 DOI: 10.1002/Cne.22034  0.355
2009 Eberling JL, Kells AP, Pivirotto P, Beyer J, Bringas J, Federoff HJ, Forsayeth J, Bankiewicz KS. Functional effects of AAV2-GDNF on the dopaminergic nigrostriatal pathway in parkinsonian rhesus monkeys. Human Gene Therapy. 20: 511-8. PMID 19254173 DOI: 10.1089/Hum.2008.201  0.318
2009 Ryan DA, Federoff HJ. Immune responses to herpesviral vectors. Human Gene Therapy. 20: 434-41. PMID 19216681 DOI: 10.1089/Hum.2009.019  0.608
2009 Johnston LC, Eberling J, Pivirotto P, Hadaczek P, Federoff HJ, Forsayeth J, Bankiewicz KS. Clinically relevant effects of convection-enhanced delivery of AAV2-GDNF on the dopaminergic nigrostriatal pathway in aged rhesus monkeys. Human Gene Therapy. 20: 497-510. PMID 19203243 DOI: 10.1089/Hum.2008.137  0.335
2009 Chiu YG, Bowers WJ, Lim ST, Ryan DA, Federoff HJ. Effects of herpes simplex virus amplicon transduction on murine dendritic cells. Human Gene Therapy. 20: 442-52. PMID 19199821 DOI: 10.1089/Hum.2008.160  0.708
2009 Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain Neuroimage. 47: T27-T35. PMID 19095069 DOI: 10.1016/J.Neuroimage.2008.11.012  0.56
2009 Daubeuf S, Singh D, Tan Y, Liu H, Federoff HJ, Bowers WJ, Tolba K. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 113: 3264-75. PMID 18952891 DOI: 10.1182/Blood-2008-07-168203  0.568
2009 Maguire-Zeiss KA, Federoff HJ. Immune-directed gene therapeutic development for Alzheimer's, prion, and Parkinson's diseases. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 298-308. PMID 18931916 DOI: 10.1007/S11481-008-9133-3  0.382
2009 Federoff HJ, Chiu YG, Bowers WJ, Lim ST, Ryan DA. Effects of HSV amplicon transduction on murine dendritic cells Human Gene Therapy. 90126111624022. DOI: 10.1089/Hgt.2008.160  0.69
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced Pathology and Improved Behavioral Performance in Alzheimer's Disease Mice Vaccinated With HSV Amplicons Expressing Amyloid-β and Interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-853. PMID 28178487 DOI: 10.1038/Mt.2008.39  0.604
2008 Schubert M, Breakefield X, Federoff H, Frederickson RM, Lowenstein PR. Gene Delivery to the Nervous System: NINDS Workshop on Gene Delivery to the Nervous System Washington, DC, 12-13 November 2007. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 640-646. PMID 28178462 DOI: 10.1038/Mt.2008.42  0.325
2008 Janelsins MC, Mastrangelo MA, Park KM, Sudol KL, Narrow WC, Oddo S, LaFerla FM, Callahan LM, Federoff HJ, Bowers WJ. Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. The American Journal of Pathology. 173: 1768-82. PMID 18974297 DOI: 10.2353/Ajpath.2008.080528  0.739
2008 Luo Y, Xing F, Guiliano R, Federoff HJ. Identification of a novel nurr1-interacting protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 9277-86. PMID 18784308 DOI: 10.1523/Jneurosci.3021-08.2008  0.33
2008 Johnston LC, Su X, Maguire-Zeiss K, Horovitz K, Ankoudinova I, Guschin D, Hadaczek P, Federoff HJ, Bankiewicz K, Forsayeth J. Human interleukin-10 gene transfer is protective in a rat model of Parkinson's disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1392-9. PMID 18545225 DOI: 10.1038/Mt.2008.113  0.561
2008 Halterman MW, De Jesus C, Rempe DA, Schor NF, Federoff HJ. Loss of c/EBP-beta activity promotes the adaptive to apoptotic switch in hypoxic cortical neurons. Molecular and Cellular Neurosciences. 38: 125-37. PMID 18439838 DOI: 10.1016/J.Mcn.2008.01.014  0.736
2008 Frazer ME, Hughes JE, Mastrangelo MA, Tibbens JL, Federoff HJ, Bowers WJ. Reduced pathology and improved behavioral performance in Alzheimer's disease mice vaccinated with HSV amplicons expressing amyloid-beta and interleukin-4. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 845-53. PMID 18388924 DOI: 10.1038/mt.2008.39  0.556
2008 Vangeison G, Carr D, Federoff HJ, Rempe DA. The good, the bad, and the cell type-specific roles of hypoxia inducible factor-1 alpha in neurons and astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1988-93. PMID 18287515 DOI: 10.1523/Jneurosci.5323-07.2008  0.303
2008 Lim ST, Lim KC, Giuliano RE, Federoff HJ. Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons. The Journal of Comparative Neurology. 507: 1228-44. PMID 18181141 DOI: 10.1002/Cne.21608  0.538
2008 Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 481-6. PMID 18180775 DOI: 10.1038/Sj.Mt.6300387  0.796
2008 Burris CA, de Silva S, Narrow WC, Casey AE, Lotta LT, Federoff HJ, Bowers WJ. Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. The Journal of Gene Medicine. 10: 152-64. PMID 18058952 DOI: 10.1002/Jgm.1130  0.726
2008 Maguire-Zeiss KA, Mhyre TR, Federoff HJ. Gazing into the future: Parkinson's disease gene therapeutics to modify natural history. Experimental Neurology. 209: 101-13. PMID 18035353 DOI: 10.1016/J.Expneurol.2007.09.030  0.328
2008 Nechushtan H, Pham D, Zhang Y, Morgensztern D, Yi KH, Shin SU, Federoff HJ, Bowers WJ, Tolba KA, Rosenblatt JD. Augmentation of anti-tumor responses of adoptively transferred CD8+T cells in the lymphopenic setting by HSV amplicon transduction. Cancer Immunology, Immunotherapy : Cii. 57: 663-75. PMID 17952436 DOI: 10.1007/S00262-007-0405-1  0.579
2008 Su X, Maguire-Zeiss KA, Giuliano R, Prifti L, Venkatesh K, Federoff HJ. Synuclein activates microglia in a model of Parkinson's disease. Neurobiology of Aging. 29: 1690-701. PMID 17537546 DOI: 10.1016/J.Neurobiolaging.2007.04.006  0.544
2008 Miller RM, Federoff HJ. Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiology of Aging. 29: 71-7. PMID 17101197 DOI: 10.1016/J.Neurobiolaging.2006.09.006  0.36
2008 Bowers WJ, Janelsins MC, Federoff HJ. Gene therapy and vaccination Neuroimmune Pharmacology. 709-724. DOI: 10.1007/978-0-387-72573-4_48  0.637
2007 Yi KH, Nechushtan H, Bowers WJ, Walker GR, Zhang Y, Pham DG, Podack ER, Federoff HJ, Tolba KA, Rosenblatt JD. Adoptively transferred tumor-specific T cells stimulated ex vivo using herpes simplex virus amplicons encoding 4-1BBL persist in the host and show antitumor activity in vivo. Cancer Research. 67: 10027-37. PMID 17942937 DOI: 10.1158/0008-5472.Can-06-2391  0.589
2007 Duke CM, Maguire CA, Keefer MC, Federoff HJ, Bowers WJ, Dewhurst S. HSV-1 amplicon vectors elicit polyfunctional T cell responses to HIV-1 Env, and strongly boost responses to an adenovirus prime. Vaccine. 25: 7410-21. PMID 17868958 DOI: 10.1016/J.Vaccine.2007.08.015  0.579
2007 Lim KC, Tyler CM, Lim ST, Giuliano R, Federoff HJ. Proteolytic processing of proNGF is necessary for mature NGF regulated secretion from neurons. Biochemical and Biophysical Research Communications. 361: 599-604. PMID 17673176 DOI: 10.1016/J.Bbrc.2007.07.039  0.704
2007 Peterson EB, Mastrangelo MA, Federoff HJ, Bowers WJ. Neuronal specificity of HSV/sleeping beauty amplicon transduction in utero is driven primarily by tropism and cell type composition. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1848-55. PMID 17653102 DOI: 10.1038/Sj.Mt.6300267  0.633
2007 Weimer JM, Benedict JW, Elshatory YM, Short DW, Ramirez-Montealegre D, Ryan DA, Alexander NA, Federoff HJ, Cooper JD, Pearce DA. Alterations in striatal dopamine catabolism precede loss of substantia nigra neurons in a mouse model of juvenile neuronal ceroid lipofuscinosis. Brain Research. 1162: 98-112. PMID 17617387 DOI: 10.1016/J.Brainres.2007.05.018  0.707
2007 Santos K, Sanfilippo CM, Narrow WC, Casey AE, Rodriguez-Colon SM, McDermott MP, Federoff HJ, Bowers WJ, Dewhurst S. Infectivity of herpes simplex virus type-1 (HSV-1) amplicon vectors in dendritic cells is determined by the helper virus strain used for packaging. Journal of Virological Methods. 145: 37-46. PMID 17606303 DOI: 10.1016/J.Jviromet.2007.05.013  0.579
2007 Ryan DA, Federoff HJ. Translational considerations for CNS gene therapy. Expert Opinion On Biological Therapy. 7: 305-18. PMID 17309323 DOI: 10.1517/14712598.7.3.305  0.611
2007 Santos K, Simon DA, Conway E, Bowers WJ, Mitra S, Foster TH, Lugade A, Lord EM, Federoff HJ, Dewhurst S, Frelinger JG. Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors. Human Gene Therapy. 18: 93-105. PMID 17298238 DOI: 10.1089/Hum.2006.082  0.644
2007 Federoff HJ, Mhyre TR. Reversal of misfolding: prion disease behavioral and physiological impairments recover following postnatal neuronal deletion of the PrP gene. Neuron. 53: 315-7. PMID 17270727 DOI: 10.1016/J.Neuron.2007.01.013  0.338
2007 Miller RM, Kiser GL, Kaysser-Kranich T, Casaceli C, Colla E, Lee MK, Palaniappan C, Federoff HJ. Wild-type and mutant alpha-synuclein induce a multi-component gene expression profile consistent with shared pathophysiology in different transgenic mouse models of PD. Experimental Neurology. 204: 421-32. PMID 17254569 DOI: 10.1016/J.Expneurol.2006.12.005  0.366
2007 Sortwell CE, Bowers WJ, Counts SE, Pitzer MR, Fleming MF, McGuire SO, Maguire-Zeiss KA, Federoff HJ, Collier TJ. Effects of ex vivo transduction of mesencephalic reaggregates with bcl-2 on grafted dopamine neuron survival. Brain Research. 1134: 33-44. PMID 17196186 DOI: 10.1016/J.Brainres.2006.11.079  0.633
2007 Santos K, Duke CM, Rodriguez-Colon SM, Dakwar A, Fan S, Keefer MC, Federoff HJ, Frelinger JG, Bowers WJ, Dewhurst S. Effect of promoter strength on protein expression and immunogenicity of an HSV-1 amplicon vector encoding HIV-1 Gag. Vaccine. 25: 1634-46. PMID 17145123 DOI: 10.1016/J.Vaccine.2006.11.004  0.615
2007 Luo Y, Henricksen LA, Giuliano RE, Prifti L, Callahan LM, Federoff HJ. VIP is a transcriptional target of Nurr1 in dopaminergic cells. Experimental Neurology. 203: 221-32. PMID 16999955 DOI: 10.1016/J.Expneurol.2006.08.005  0.349
2007 Tan Y, Rosenblatt JD, Federoff HJ, Bowers WJ, Tolba KA. Regulation of TLR Signaling by USP7. Blood. 110: 2300-2300. DOI: 10.1182/Blood.V110.11.2300.2300  0.582
2006 Halterman MW, Giuliano RE, Bowers WJ, Federoff HJ. Improved HSV-1 amplicon packaging using virion host shutoff mutants lacking mRNAse activity. The Journal of Gene Medicine. 8: 1320-8. PMID 16989006 DOI: 10.1002/Jgm.972  0.764
2006 Maguire-Zeiss KA, Wang CI, Yehling E, Sullivan MA, Short DW, Su X, Gouzer G, Henricksen LA, Wuertzer CA, Federoff HJ. Identification of human alpha-synuclein specific single chain antibodies. Biochemical and Biophysical Research Communications. 349: 1198-205. PMID 16973126 DOI: 10.1016/J.Bbrc.2006.08.127  0.775
2006 Miller RM, Federoff HJ. Microarrays in Parkinson's disease: a systematic approach. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 3: 319-26. PMID 16815215 DOI: 10.1016/J.Nurx.2006.05.008  0.321
2006 Tyler CM, Wuertzer CA, Bowers WJ, Federoff HJ. HSV amplicons: neuro applications. Current Gene Therapy. 6: 337-50. PMID 16787185 DOI: 10.2174/156652306777592045  0.792
2006 Tyler CM, Federoff HJ. CNS gene therapy and a nexus of complexity: systems and biology at a crossroads. Cell Transplantation. 15: 267-73. PMID 16719061 DOI: 10.3727/000000006783982007  0.665
2006 Rempe D, Vangeison G, Hamilton J, Li Y, Jepson M, Federoff HJ. Synapsin I Cre transgene expression in male mice produces germline recombination in progeny. Genesis (New York, N.Y. : 2000). 44: 44-9. PMID 16419044 DOI: 10.1002/Gene.20183  0.33
2006 Bowers WJ, Mastrangelo MA, Howard DF, Southerland HA, Maguire-Zeiss KA, Federoff HJ. Neuronal precursor-restricted transduction via in utero CNS gene delivery of a novel bipartite HSV amplicon/transposase hybrid vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 580-8. PMID 16412694 DOI: 10.1016/J.Ymthe.2005.11.011  0.644
2006 Weimer JM, Custer AW, Benedict JW, Alexander NA, Kingsley E, Federoff HJ, Cooper JD, Pearce DA. Visual deficits in a mouse model of Batten disease are the result of optic nerve degeneration and loss of dorsal lateral geniculate thalamic neurons. Neurobiology of Disease. 22: 284-93. PMID 16412658 DOI: 10.1016/J.Nbd.2005.11.008  0.598
2006 Arvanian VL, Bowers WJ, Anderson A, Horner PJ, Federoff HJ, Mendell LM. Combined delivery of neurotrophin-3 and NMDA receptors 2D subunit strengthens synaptic transmission in contused and staggered double hemisected spinal cord of neonatal rat. Experimental Neurology. 197: 347-52. PMID 16289170 DOI: 10.1016/J.Expneurol.2005.10.008  0.538
2006 Miller RM, Kiser GL, Kaysser-Kranich TM, Lockner RJ, Palaniappan C, Federoff HJ. Robust dysregulation of gene expression in substantia nigra and striatum in Parkinson's disease. Neurobiology of Disease. 21: 305-13. PMID 16143538 DOI: 10.1016/J.Nbd.2005.07.010  0.366
2006 Tolba KA, Bowers W, Tan Y, Daubeuf S, Federoff HJ, Rosenblatt JD. HSV ICP0 Inhibits TLR-Mediated NF-κB Response to TLR Signaling. Blood. 108: 5487-5487. DOI: 10.1182/blood.v108.11.5487.5487  0.517
2006 Janelsins MC, Mastrangelo MA, Park KM, Fowlkes KL, Kinsky M, Narrow WC, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. 248. Revealing the Role(s) of TNF-alpha in Early Alzheimer's Disease Via rAAV-Mediated Hippocampal Gene Transfer in a Triple Transgenic Mouse Model Molecular Therapy. 13: S95. DOI: 10.1016/J.Ymthe.2006.08.275  0.701
2006 Fowlkes KL, Mastrangelo MA, Narrow WC, Levites Y, Golde TE, Federoff HJ, Bowers WJ. 247. Devising Aβ-Specific Passive Immunization Strategies for Alzheimer's Disease Using rAAV Vector-Mediated scFv Antibody Delivery Molecular Therapy. 13: S94-S95. DOI: 10.1016/J.Ymthe.2006.08.274  0.593
2005 Maguire-Zeiss KA, Federoff HJ. Novel gene therapeutic strategies for neurodegenerative diseases. Ernst Schering Research Foundation Workshop. 147-71. PMID 16315613 DOI: 10.1007/3-540-27626-2_9  0.336
2005 Federoff HJ, Bowers WJ. Immune shaping and the development of Alzheimer's disease vaccines. Science of Aging Knowledge Environment : Sage Ke. 2005: pe35. PMID 16293586 DOI: 10.1126/Sageke.2005.46.Pe35  0.575
2005 Miller RM, Federoff HJ. Altered gene expression profiles reveal similarities and differences between Parkinson disease and model systems. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 11: 539-49. PMID 16282595 DOI: 10.1177/1073858405278330  0.38
2005 Reinblatt M, Pin RH, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible soluble vascular endothelial growth factor receptor (sFlk-1) inhibits angiogenesis and tumor growth in pancreatic adenocarcinoma. Annals of Surgical Oncology. 12: 1025-36. PMID 16244806 DOI: 10.1245/Aso.2005.03.081  0.577
2005 Janelsins MC, Mastrangelo MA, Oddo S, LaFerla FM, Federoff HJ, Bowers WJ. Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. Journal of Neuroinflammation. 2: 23. PMID 16232318 DOI: 10.1186/1742-2094-2-23  0.686
2005 Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ. beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Research. Molecular Brain Research. 133: 286-98. PMID 15710246 DOI: 10.1016/J.Molbrainres.2004.10.026  0.338
2005 Miller RM, Chen LL, Kiser GL, Giesler TL, Kaysser-Kranich TM, Palaniappan C, Federoff HJ. Temporal evolution of mouse striatal gene expression following MPTP injury. Neurobiology of Aging. 26: 765-75. PMID 15708451 DOI: 10.1016/J.Neurobiolaging.2004.12.002  0.328
2005 Gorantla S, Santos K, Meyer V, Dewhurst S, Bowers WJ, Federoff HJ, Gendelman HE, Poluektova L. Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge. Journal of Virology. 79: 2124-32. PMID 15681415 DOI: 10.1128/Jvi.79.4.2124-2132.2005  0.58
2005 Bowers WJ, Mastrangelo MA, Stanley HA, Casey AE, Milo LJ, Federoff HJ. HSV amplicon-mediated Abeta vaccination in Tg2576 mice: differential antigen-specific immune responses. Neurobiology of Aging. 26: 393-407. PMID 15653168 DOI: 10.1016/J.Neurobiolaging.2004.04.006  0.593
2005 Daubeuf S, Rosenblatt JD, Bowers WJ, Federoff HJ, Tolba KA. HSV Encoded ICP-0 Inhibits TLR Signaling in CLL Cells by Targeting TRAF-6. Blood. 106: 2953-2953. DOI: 10.1182/Blood.V106.11.2953.2953  0.608
2005 Wuertzer CA, Sullivan MA, Federoff HJ. 966. AAV Delivered Single-Chain Antibodies as Passive Immuno-Therapy for Prion Disease Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.509  0.788
2005 Bowers WJ, Mastrangelo MA, Casey AE, Southerland HA, Maguire-Zeiss KA, Federoff HJ. 431. In Utero CNS Delivery of an Integrating HSV-1 Amplicon Vector Leads to Prolonged, Neuron-Specific Gene Expression Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.433  0.631
2004 Wang H, Yu SW, Koh DW, Lew J, Coombs C, Bowers W, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10963-73. PMID 15574746 DOI: 10.1523/Jneurosci.3461-04.2004  0.553
2004 Pin RH, Reinblatt M, Bowers WJ, Federoff HJ, Fong Y. Herpes simplex virus amplicon delivery of a hypoxia-inducible angiogenic inhibitor blocks capillary formation in hepatocellular carcinoma. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 8: 812-22; discussion 8. PMID 15531234 DOI: 10.1016/J.Gassur.2004.08.007  0.588
2004 Miller RM, Callahan LM, Casaceli C, Chen L, Kiser GL, Chui B, Kaysser-Kranich TM, Sendera TJ, Palaniappan C, Federoff HJ. Dysregulation of gene expression in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mouse substantia nigra. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7445-54. PMID 15329391 DOI: 10.1523/Jneurosci.4204-03.2004  0.367
2004 Reinblatt M, Pin RH, Federoff HJ, Fong Y. Utilizing tumor hypoxia to enhance oncolytic viral therapy in colorectal metastases. Annals of Surgery. 239: 892-9; discussion 89. PMID 15166969 DOI: 10.1097/01.Sla.0000128308.36393.38  0.319
2004 Arvanian VL, Bowers WJ, Petruska JC, Motin V, Manuzon H, Narrow WC, Federoff HJ, Mendell LM. Viral delivery of NR2D subunits reduces Mg2+ block of NMDA receptor and restores NT-3-induced potentiation of AMPA-kainate responses in maturing rat motoneurons. Journal of Neurophysiology. 92: 2394-404. PMID 15152019 DOI: 10.1152/Jn.00278.2004  0.56
2004 Abeysinghe HR, Pollock SJ, Guckert NL, Veyberman Y, Keng P, Halterman M, Federoff HJ, Rosenblatt JP, Wang N. The role of the THY1 gene in human ovarian cancer suppression based on transfection studies. Cancer Genetics and Cytogenetics. 149: 1-10. PMID 15104276 DOI: 10.1016/S0165-4608(03)00234-6  0.667
2004 Daubeuf S, Rosenblatt JD, Bowers WJ, Urbistondo NT, Federoff HJ, Tolba KA. HSV Amplicon Transduction Activates an Innate Immune Response in CLL B Cells;Implications for Immune Therapy and Vaccine Development. Blood. 104: 2514-2514. DOI: 10.1182/Blood.V104.11.2514.2514  0.605
2004 Bowers WJ, Mastrangelo MA, Stanley HA, Chiu Y, Federoff HJ. P4-340 Immunological assessment of acute CNS inflammatory processes elicited in an Alzheimer's disease mouse model following HSV amplicon-based Aβ vaccination Neurobiology of Aging. 25: S572. DOI: 10.1016/S0197-4580(04)81898-0  0.572
2004 Callahan LM, Edwards K, Maguire-Zeiss KA, Bowers WJ, Narrow WC, Kang S, Mastrangelo MA, Giuliano RE, Federoff HJ. P3-259 Expression of pathogenic tau, P301L, leads to microtubule disruption in hippocampal neurons Neurobiology of Aging. 25: S428. DOI: 10.1016/S0197-4580(04)81409-X  0.57
2004 Wuertzer CA, Sullivan MA, Federoff HJ. 552. Single-Chain Antibodies for Viral-Based Passive Immuno-Therapy for Prion Disease: Linear Epitope Mapping and Clearance from Thalamic Injection Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.471  0.785
2004 Janelsins MC, Mastrangelo MA, Federoff HJ, Bowers WJ. 226. Developing a CNS-Specific Inflammatory Model To Investigate Gene Therapy/Inflammation Interactions in the Context of Neurodegeneration|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.170  0.726
2004 Maguire-Zeiss KA, Yehling E, Giuliano R, Sullivan M, Federoff HJ. 222. HSV Amplicon Expression of Single Chain Antibodies Directed Against |[alpha]|-Synuclein Conformers Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.165  0.311
2004 Stanley HA, Bowers WJ, Mastrangelo MA, Federoff HJ. 211. Creation of a HSV VP22-Sleeping Beauty Fusion Protein To Facilitate Integration of HSV-1 Amplicon Vectors|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.152  0.616
2004 Bowers WJ, Mastrangelo MA, Stanley HA, Chiu Y, Federoff HJ. 43. Immunological Response Characterization in an Alzheimer's Disease Mouse Model Following HSV Amplicon-Based A|[beta]| Vaccination|[ast]| Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.05.068  0.6
2003 Lim KC, Lim ST, Federoff HJ. Neurotrophin secretory pathways and synaptic plasticity. Neurobiology of Aging. 24: 1135-45. PMID 14643385 DOI: 10.1016/J.Neurobiolaging.2003.09.003  0.529
2003 Kyrkanides S, Miller Jn, Bowers WJ, Federoff HJ. Transcriptional and posttranslational regulation of Cre recombinase by RU486 as the basis for an enhanced inducible expression system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 790-5. PMID 14599812 DOI: 10.1016/J.Ymthe.2003.07.005  0.588
2003 Kyrkanides S, Miller JH, Federoff HJ. Systemic FIV vector administration: transduction of CNS immune cells and Purkinje neurons. Brain Research. Molecular Brain Research. 119: 1-9. PMID 14597224 DOI: 10.1016/J.Molbrainres.2003.08.016  0.383
2003 Tariot PN, Federoff HJ. Current treatment for Alzheimer disease and future prospects. Alzheimer Disease and Associated Disorders. 17: S105-13. PMID 14512816 DOI: 10.1097/00002093-200307004-00005  0.321
2003 Harvey BK, Chang CF, Chiang YH, Bowers WJ, Morales M, Hoffer BJ, Wang Y, Federoff HJ. HSV amplicon delivery of glial cell line-derived neurotrophic factor is neuroprotective against ischemic injury. Experimental Neurology. 183: 47-55. PMID 12957487 DOI: 10.1016/S0014-4886(03)00080-3  0.745
2003 Zhang Y, Hong Y, Bounhar Y, Blacker M, Roucou X, Tounekti O, Vereker E, Bowers WJ, Federoff HJ, Goodyer CG, LeBlanc A. p75 neurotrophin receptor protects primary cultures of human neurons against extracellular amyloid beta peptide cytotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7385-94. PMID 12917374 DOI: 10.1523/Jneurosci.23-19-07385.2003  0.54
2003 Maguire-Zeiss KA, Federoff HJ. Convergent pathobiologic model of Parkinson's disease. Annals of the New York Academy of Sciences. 991: 152-66. PMID 12846984 DOI: 10.1111/J.1749-6632.2003.Tb07473.X  0.308
2003 Bowers WJ, Olschowka JA, Federoff HJ. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Therapy. 10: 941-5. PMID 12756414 DOI: 10.1038/Sj.Gt.3302047  0.637
2003 Wang X, Wiley RD, Evans TG, Bowers WJ, Federoff HJ, Dewhurst S. Cellular immune responses to helper-free HSV-1 amplicon particles encoding HIV-1 gp120 are enhanced by DNA priming. Vaccine. 21: 2288-97. PMID 12744859 DOI: 10.1016/S0264-410X(03)00099-9  0.579
2003 Jarnagin WR, Zager JS, Klimstra D, Delman KA, Malhotra S, Ebright M, Little S, DeRubertis B, Stanziale SF, Hezel M, Federoff H, Fong Y. Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects against recurrence-after resection. Cancer Gene Therapy. 10: 215-23. PMID 12637943 DOI: 10.1038/Sj.Cgt.7700558  0.327
2003 Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 218-27. PMID 12597910 DOI: 10.1016/S1525-0016(02)00036-9  0.64
2003 Snyder JE, Bowers WJ, Livingstone AM, Lee FE, Federoff HJ, Mosmann TR. Measuring the frequency of mouse and human cytotoxic T cells by the Lysispot assay: independent regulation of cytokine secretion and short-term killing. Nature Medicine. 9: 231-5. PMID 12539041 DOI: 10.1038/Nm821  0.602
2003 Miller RM, Casaceli C, Chen L, Federoff HJ. Gene expression analysis of the MPTP-lesioned substantia nigra in mice Annals of the New York Academy of Sciences. 991: 315-318. DOI: 10.1111/J.1749-6632.2003.Tb07494.X  0.301
2002 Tolba KA, Bowers WJ, Muller J, Housekneckt V, Giuliano RE, Federoff HJ, Rosenblatt JD. Herpes simplex virus (HSV) amplicon-mediated codelivery of secondary lymphoid tissue chemokine and CD40L results in augmented antitumor activity. Cancer Research. 62: 6545-51. PMID 12438249  0.553
2002 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. Somatic mosaic approaches and the aging brain. Neurobiology of Aging. 23: 977-84. PMID 12392799 DOI: 10.1016/S0197-4580(02)00077-5  0.588
2002 Bowers WJ, Federoff HJ. Amyloid immunotherapy-engendered CNS inflammation. Neurobiology of Aging. 23: 675-6; discussion 68. PMID 12392770 DOI: 10.1016/S0197-4580(02)00035-0  0.547
2002 Bennett JJ, Delman KA, Burt BM, Mariotti A, Malhotra S, Zager J, Petrowsky H, Mastorides S, Federoff H, Fong Y. Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer. Cancer Gene Therapy. 9: 935-45. PMID 12386832 DOI: 10.1038/Sj.Cgt.7700510  0.342
2002 Tolba KA, Bowers WJ, Eling DJ, Casey AE, Kipps TJ, Federoff HJ, Rosenblatt JD. HSV amplicon-mediated delivery of LIGHT enhances the antigen-presenting capacity of chronic lymphocytic leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 455-63. PMID 12377186 DOI: 10.1006/Mthe.2002.0693  0.593
2002 Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Annals of Surgery. 236: 337-42; discussion 3. PMID 12192320 DOI: 10.1097/00000658-200209000-00010  0.667
2002 Casper D, Engstrom SJ, Mirchandani GR, Pidel A, Palencia D, Cho PH, Brownlee M, Edelstein D, Federoff HJ, Sonstein WJ. Enhanced vascularization and survival of neural transplants with ex vivo angiogenic gene transfer. Cell Transplantation. 11: 331-49. PMID 12162374 DOI: 10.3727/000000002783985828  0.305
2002 Yu SW, Wang H, Poitras MF, Coombs C, Bowers WJ, Federoff HJ, Poirier GG, Dawson TM, Dawson VL. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science (New York, N.Y.). 297: 259-63. PMID 12114629 DOI: 10.1126/Science.1072221  0.548
2002 Bowers WJ, Chen X, Guo H, Frisina DR, Federoff HJ, Frisina RD. Neurotrophin-3 transduction attenuates cisplatin spiral ganglion neuron ototoxicity in the cochlea. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 12-8. PMID 12095298 DOI: 10.1006/Mthe.2002.0627  0.631
2002 Detrait ER, Bowers WJ, Halterman MW, Giuliano RE, Bennice L, Federoff HJ, Richfield EK. Reporter gene transfer induces apoptosis in primary cortical neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 723-30. PMID 12027556 DOI: 10.1006/Mthe.2002.0609  0.758
2002 Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Experimental Neurology. 175: 35-48. PMID 12009758 DOI: 10.1006/Exnr.2002.7882  0.78
2002 Hocknell PK, Wiley RD, Wang X, Evans TG, Bowers WJ, Hanke T, Federoff HJ, Dewhurst S. Expression of human immunodeficiency virus type 1 gp120 from herpes simplex virus type 1-derived amplicons results in potent, specific, and durable cellular and humoral immune responses. Journal of Virology. 76: 5565-80. PMID 11991985 DOI: 10.1128/Jvi.76.11.5565-5580.2002  0.604
2002 Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff HJ, Davidson BL. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proceedings of the National Academy of Sciences of the United States of America. 99: 6216-21. PMID 11959904 DOI: 10.1073/Pnas.082011999  0.364
2002 Halaby IA, Lyden SP, Davies MG, Roztocil E, Salamone LJ, Brooks AI, Green RM, Federoff HJ, Bowers WJ. Glucocorticoid-regulated VEGF expression in ischemic skeletal muscle. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 300-6. PMID 11863420 DOI: 10.1006/Mthe.2002.0539  0.576
2002 Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development (Cambridge, England). 129: 467-77. PMID 11807038  0.502
2001 Maguire-Zeiss KA, Bowers WJ, Federoff HJ. HSV vector-mediated gene delivery to the central nervous system. Current Opinion in Molecular Therapeutics. 3: 482-90. PMID 11699893  0.594
2001 Willis RA, Bowers WJ, Turner MJ, Fisher TL, Abdul-Alim CS, Howard DF, Federoff HJ, Lord EM, Frelinger JG. Dendritic cells transduced with HSV-1 amplicons expressing prostate-specific antigen generate antitumor immunity in mice. Human Gene Therapy. 12: 1867-79. PMID 11589829 DOI: 10.1089/104303401753153929  0.608
2001 Carew JF, Kooby DA, Halterman MW, Kim SH, Federoff HJ, Fong Y. A novel approach to cancer therapy using an oncolytic herpes virus to package amplicons containing cytokine genes. Molecular Therapy : the Journal of the American Society of Gene Therapy. 4: 250-6. PMID 11545616 DOI: 10.1006/Mthe.2001.0448  0.661
2001 Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G. Regulation of neuronal traits by a novel transcriptional complex. Neuron. 31: 353-65. PMID 11516394 DOI: 10.1016/S0896-6273(01)00371-3  0.59
2001 Petrowsky H, Roberts GD, Kooby DA, Burt BM, Bennett JJ, Delman KA, Stanziale SF, Delohery TM, Tong WP, Federoff HJ, Fong Y. Functional interaction between fluorodeoxyuridine-induced cellular alterations and replication of a ribonucleotide reductase-negative herpes simplex virus. Journal of Virology. 75: 7050-8. PMID 11435585 DOI: 10.1128/Jvi.75.15.7050-7058.2001  0.333
2001 Tolba KA, Bowers WJ, Hilchey SP, Halterman MW, Howard DF, Giuliano RE, Federoff HJ, Rosenblatt JD. Development of herpes simplex virus-1 amplicon-based immunotherapy for chronic lymphocytic leukemia. Blood. 98: 287-95. PMID 11435295 DOI: 10.1182/Blood.V98.2.287  0.754
2001 Chen X, Frisina RD, Bowers WJ, Frisina DR, Federoff HJ. HSV amplicon-mediated neurotrophin-3 expression protects murine spiral ganglion neurons from cisplatin-induced damage. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 958-63. PMID 11407910 DOI: 10.1006/Mthe.2001.0334  0.643
2001 Cozzi PJ, Malhotra S, McAuliffe P, Kooby DA, Federoff HJ, Huryk B, Johnson P, Scardino PT, Heston WD, Fong Y. Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 1306-8. PMID 11344122 DOI: 10.1096/Fj.00-0533Fje  0.333
2001 Bowers WJ, Howard DF, Brooks AI, Halterman MW, Federoff HJ. Expression of vhs and VP16 during HSV-1 helper virus-free amplicon packaging enhances titers. Gene Therapy. 8: 111-20. PMID 11313780 DOI: 10.1038/Sj.Gt.3301340  0.756
2001 Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410: 89-93. PMID 11242047 DOI: 10.1038/35065091  0.536
2001 Brooks AD, Ng B, Liu D, Brownlee M, Burt M, Federoff HJ, Fong Y. Specific organ gene transfer in vivo by regional organ perfusion with herpes viral amplicon vectors: implications for local gene therapy. Surgery. 129: 324-34. PMID 11231461 DOI: 10.1067/Msy.2001.111697  0.336
2001 Bowers WJ, Maguire-Zeiss KA, Harvey BK, Federoff HJ. Gene therapeutic approaches to the treatment of Parkinson's disease Clinical Neuroscience Research. 1: 483-495. DOI: 10.1016/S1566-2772(01)00026-3  0.714
2001 Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. Combination Vascular Delivery of Herpes Simplex Oncolytic Viruses and Amplicon Mediated Cytokine Gene Transfer Is Effective Therapy for Experimental Liver Cancer Molecular Medicine. 7: 561-568. DOI: 10.1007/Bf03401862  0.664
2000 McAuliffe PF, Jarnagin WR, Johnson P, Delman KA, Federoff H, Fong Y. Effective Treatment of Pancreatic Tumors with Two Multimutated Herpes Simplex Oncolytic Viruses Journal of Gastrointestinal Surgery. 4: 580-588. PMID 11307092 DOI: 10.1016/S1091-255X(00)80106-7  0.327
2000 Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Human Gene Therapy. 11: 2341-52. PMID 11096439 DOI: 10.1089/104303400750038453  0.561
2000 Brooks AI, Cory-Slechta DA, Federoff HJ. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proceedings of the National Academy of Sciences of the United States of America. 97: 13378-83. PMID 11078505 DOI: 10.1073/Pnas.230169397  0.345
2000 Bowers WJ, Howard DF, Federoff HJ. Discordance between expression and genome transfer titering of HSV amplicon vectors: recommendation for standardized enumeration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 1: 294-9. PMID 10933945 DOI: 10.1006/Mthe.2000.0039  0.632
2000 Bennett JJ, Kooby DA, Delman K, McAuliffe P, Halterman MW, Federoff H, Fong Y. Antitumor efficacy of regional oncolytic viral therapy for peritoneally disseminated cancer Journal of Molecular Medicine. 78: 166-174. PMID 10868479 DOI: 10.1007/S001090000092  0.671
2000 Karpoff HM, Kooby D, D'Angelica M, Mack J, Presky DH, Brownlee MD, Federoff H, Fong Y. Efficient cotransduction of tumors by multiple herpes simplex vectors: implications for tumor vaccine production. Cancer Gene Therapy. 7: 581-8. PMID 10811476 DOI: 10.1038/Sj.Cgt.7700135  0.367
2000 Jarnagin WR, Delman K, Kooby D, Mastorides S, Zager J, Brennan MF, Blumgart LH, Federoff H, Fong Y. Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. Annals of Surgery. 231: 762-71. PMID 10767798 DOI: 10.1097/00000658-200005000-00017  0.321
1999 Van de Water TR, Staecker H, Halterman MW, Federoff HJ. Gene therapy in the inner ear. Mechanisms and clinical implications. Annals of the New York Academy of Sciences. 884: 345-60. PMID 10842605 DOI: 10.1111/J.1749-6632.1999.Tb08653.X  0.691
1999 Halterman MW, Federoff HJ. HIF-1alpha and p53 promote hypoxia-induced delayed neuronal death in models of CNS ischemia. Experimental Neurology. 159: 65-72. PMID 10486175 DOI: 10.1006/Exnr.1999.7160  0.676
1999 Lee JH, Federoff HJ, Schoeniger LO. G207, modified herpes simplex virus type 1, kills human pancreatic cancer cells in vitro. Journal of Gastrointestinal Surgery : Official Journal of the Society For Surgery of the Alimentary Tract. 3: 127-31; discussion 1. PMID 10457334 DOI: 10.1016/S1091-255X(99)80021-3  0.348
1999 Halterman MW, Miller CC, Federoff HJ. Hypoxia-inducible factor-1alpha mediates hypoxia-induced delayed neuronal death that involves p53. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6818-24. PMID 10436039  0.645
1999 Kooby DA, Carew JF, Halterman MW, Mack JE, Bertino JR, Blumgart LH, Federoff HJ, Fong Y. Oncolytic viral therapy for human colorectal cancer and liver metastases using a multi-mutated herpes simplex virus type-1 (G207). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 1325-34. PMID 10428757 DOI: 10.1096/Fasebj.13.11.1325  0.65
1999 Carew JF, Kooby DA, Halterman MW, Federoff HJ, Fong Y. Selective infection and cytolysis of human head and neck squamous cell carcinoma with sparing of normal mucosa by a cytotoxic herpes simplex virus type 1 (G207). Human Gene Therapy. 10: 1599-606. PMID 10428205 DOI: 10.1089/10430349950017608  0.663
1999 Brooks AI, Halterman MW, Federoff HJ. Focal hippocampal gain of NGF function elicits specific septal cholinergic reorganization. Neuroreport. 10: 337-44. PMID 10203332 DOI: 10.1097/00001756-199902050-00024  0.662
1999 Antonawich FJ, Federoff HJ, Davis JN. BCL-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Experimental Neurology. 156: 130-7. PMID 10192784 DOI: 10.1006/Exnr.1998.7004  0.319
1999 D'Angelica M, Karpoff H, Halterman M, Ellis J, Klimstra D, Edelstein D, Brownlee M, Federoff H, Fong Y. In vivo interleukin-2 gene therapy of established tumors with herpes simplex amplicon vectors. Cancer Immunology, Immunotherapy : Cii. 47: 265-71. PMID 10022470 DOI: 10.1007/S002620050530  0.679
1999 Kutubuddin M, Federoff HJ, Challita-Eid PM, Halterman M, Day B, Atkinson M, Planelles V, Rosenblatt JD. Eradication of pre-established lymphoma using herpes simplex virus amplicon vectors. Blood. 93: 643-54. PMID 9885227 DOI: 10.1182/Blood.V93.2.643.402K24_643_654  0.673
1999 Halterman MW, Miller CC, Federoff HJ. Hypoxia-Inducible Factor-1α Mediates Hypoxia-Induced Delayed Neuronal Death That Involves p53 The Journal of Neuroscience. 19: 6818-6824. DOI: 10.1523/Jneurosci.19-16-06818.1999  0.671
1999 Federoff HJ, Myers G. Gene Therapy for Neurological Disorders and Brain Tumors Neurology. 52: 678-678. DOI: 10.1212/Wnl.52.3.678  0.394
1999 Tolba K, Federoff HJ, Bowers W, Facciponte J, Baka J, Challita-Eid P, Rosenblatt JD. Helper-Free Herpes Simplex Virus Amplicons allow Efficient Transduction of Leukemia Cells with a costimulatory ligand without Loss of MHC-I Expression Journla of Immunotherapy. 22: 466. DOI: 10.1097/00002371-199909000-00058  0.59
1999 Tolba K, Federoff HJ, Halterman M, Newman C, Challita-Eid P, Rosenblatt JD. SDF-1 MEDIATED IMMUNE EFFECTOR CELL RECRUITMENT USING HSV AMPLICON VECTORS Journla of Immunotherapy. 22: 466. DOI: 10.1097/00002371-199909000-00057  0.333
1999 D’Angelica M, Tung C, Allen P, Halterman M, Delman K, Delohery T, Klimstra D, Brownlee M, Federoff H, Fong Y. Herpes Simplex Virus (HSV)-Mediated ICAM-1 Gene Transfer Abrogates Tumorigenicity and Induces Anti-Tumor Immunity Molecular Medicine. 5: 606-616. DOI: 10.1007/Bf03402073  0.684
1998 Carew JF, Federoff H, Halterman M, Kraus DH, Savage H, Sacks PG, Schantz SP, Shah JP, Fong Y. Efficient gene transfer to human squamous cell carcinomas by the herpes simplex virus type 1 amplicon vector. American Journal of Surgery. 176: 404-8. PMID 9874422 DOI: 10.1016/S0002-9610(98)00231-1  0.672
1998 Staecker H, Gabaizadeh R, Federoff H, Van De Water TR. Brain-derived neurotrophic factor gene therapy prevents spiral ganglion degeneration after hair cell loss. Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery. 119: 7-13. PMID 9674508 DOI: 10.1016/S0194-5998(98)70194-9  0.332
1998 Brooks AI, Halterman MW, Chadwick CA, Davidson BL, Haak-Frendscho M, Radel C, Porter C, Federoff HJ. Reproducible and efficient murine CNS gene delivery using a microprocessor-controlled injector. Journal of Neuroscience Methods. 80: 137-47. PMID 9667386 DOI: 10.1016/S0165-0270(97)00207-0  0.673
1997 Federoff HJ, Halterman MW, Brooks AI. Use of the herpes amplicon system as a vehicle for somatic gene transfer. Advanced Drug Delivery Reviews. 27: 29-39. PMID 10837549 DOI: 10.1016/S0169-409X(97)00020-3  0.693
1997 Lu B, Federoff HJ, Wang Y, Goldsmith LA, Scott G. Topical application of viral vectors for epidermal gene transfer. The Journal of Investigative Dermatology. 108: 803-8. PMID 9129236 DOI: 10.1111/1523-1747.Ep12292254  0.385
1997 Bowers WJ, Howard DF, Federoff HJ. Gene therapeutic strategies for neuroprotection: implications for Parkinson's disease. Experimental Neurology. 144: 58-68. PMID 9126153 DOI: 10.1006/Exnr.1996.6389  0.639
1997 Federoff HJ, Brooks A, Muhkerjee B, Corden T. Somatic gene transfer approaches to manipulate neural networks. Journal of Neuroscience Methods. 71: 133-42. PMID 9125382 DOI: 10.1016/S0165-0270(96)00133-1  0.339
1997 Karpoff HM, D'Angelica M, Blair S, Brownlee MD, Federoff H, Fong Y. Prevention of hepatic tumor metastases in rats with herpes viral vaccines and gamma-interferon. Journal of Clinical Investigation. 99: 799-804. PMID 9045885 DOI: 10.1172/Jci119226  0.306
1997 Brooks AI, Muhkerjee B, Panahian N, Cory-Slechta D, Federoff HJ. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nature Biotechnology. 15: 57-62. PMID 9035107 DOI: 10.1038/Nbt0197-57  0.369
1997 Halterman MW, Federoff HJ. Molecular Modification of Neural Networks: Altering Synaptic Function Through the use of Viral Mediated Gene Transfer Advances in Organ Biology. 2: 113-135. DOI: 10.1016/S1569-2590(08)60183-4  0.639
1996 Tung C, Federoff HJ, Brownlee M, Karpoff H, Weigel T, Brennan MF, Fong Y. Rapid production of interleukin-2-secreting tumor cells by herpes simplex virus-mediated gene transfer: implications for autologous vaccine production. Human Gene Therapy. 7: 2217-24. PMID 8953312 DOI: 10.1089/Hum.1996.7.18-2217  0.359
1996 Jin BK, Belloni M, Conti B, Federoff HJ, Starr R, Son JH, Baker H, Joh TH. Prolonged in vivo gene expression driven by a tyrosine hydroxylase promoter in a defective herpes simplex virus amplicon vector. Human Gene Therapy. 7: 2015-24. PMID 8930662 DOI: 10.1089/Hum.1996.7.16-2015  0.408
1996 Geschwind MD, Hartnick CJ, Liu W, Amat J, Van De Water TR, Federoff HJ. Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: model for treatment of neuron loss following cochlear degeneration. Human Gene Therapy. 7: 173-82. PMID 8788168 DOI: 10.1089/Hum.1996.7.2-173  0.384
1996 Goodman LJ, Valverde J, Lim F, Geschwind MD, Federoff HJ, Geller AI, Hefti F. Regulated release and polarized localization of brain-derived neurotrophic factor in hippocampal neurons. Molecular and Cellular Neurosciences. 7: 222-38. PMID 8726105 DOI: 10.1006/Mcne.1996.0017  0.32
1995 Andrade-Rozental AF, Rozental R, Hassankhani A, Spray DC, Federoff HJ. Characterization of two populations of ectopic cells isolated from the hearts of NGF transgenic mice. Developmental Biology. 169: 533-46. PMID 7781897 DOI: 10.1006/Dbio.1995.1167  0.303
1995 Hassankhani A, Steinhelper ME, Soonpaa MH, Katz EB, Taylor DA, Andrade-Rozental A, Factor SM, Steinberg JJ, Field LJ, Federoff HJ. Overexpression of NGF within the heart of transgenic mice causes hyperinnervation, cardiac enlargement, and hyperplasia of ectopic cells. Developmental Biology. 169: 309-21. PMID 7750647 DOI: 10.1006/Dbio.1995.1146  0.32
1995 Fong Y, Federoff HJ, Brownlee M, Blumberg D, Blumgart LH, Brennan MF. Rapid and efficient gene transfer in Human hepatocytes by herpes viral vectors. Hepatology (Baltimore, Md.). 22: 723-9. PMID 7657275 DOI: 10.1002/Hep.1840220306  0.365
1995 Lu B, Federoff HJ. Herpes simplex virus type 1 amplicon vectors with glucocorticoid-inducible gene expression. Human Gene Therapy. 6: 419-28. PMID 7612699 DOI: 10.1089/Hum.1995.6.4-419  0.356
1995 Linnik MD, Zahos P, Geschwind MD, Federoff HJ. Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke; a Journal of Cerebral Circulation. 26: 1670-4; discussion 1. PMID 7544927 DOI: 10.1161/01.Str.26.9.1670  0.326
1995 Mesri EA, Federoff HJ, Brownlee M. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circulation Research. 76: 161-7. PMID 7530606 DOI: 10.1161/01.Res.76.2.161  0.332
1995 Fong Y, Federoff HJ, Brownlee M, Blumberg D, Blumgart LH, Brennan MF. Other clinical studyRapid and efficient gene transfer in human hepatocytes by herpes viral vectors Hepatology. 22. DOI: 10.1016/0270-9139(95)90289-9  0.366
1994 De Leon JR, Federoff HJ, Dickson DW, Vikstrom KL, Fishman GI. Cardiac and skeletal myopathy in beta myosin heavy-chain simian virus 40 tsA58 transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 519-23. PMID 8290557 DOI: 10.1073/Pnas.91.2.519  0.326
1994 Starr RG, Lu B, Federoff HJ. Functional characterization of the rat GAP-43 promoter. Brain Research. 638: 211-20. PMID 8199862 DOI: 10.1016/0006-8993(94)90652-1  0.323
1994 Xu H, Federoff H, Maragos J, Parada LF, Kessler JA. Viral transduction of trkA into cultured nodose and spinal motor neurons conveys NGF responsiveness. Developmental Biology. 163: 152-61. PMID 8174770 DOI: 10.1006/Dbio.1994.1131  0.314
1994 Geschwind MD, Kessler JA, Geller AI, Federoff HJ. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Transfer of the NGF gene into cells by a HSV-1 vector. Brain Research. Molecular Brain Research. 24: 327-35. PMID 7968372 DOI: 10.1016/0169-328X(94)90146-5  0.37
1994 Geschwind MD, Lu B, Federoff HJ. Expression of Neurotrophic Genes from Herpes Simplex Virus Type 1 Vectors: Modifying Neuronal Phenotype Methods in Neurosciences. 21: 462-482. DOI: 10.1016/B978-0-12-185291-7.50033-3  0.404
1993 Bergold PJ, Casaccia-Bonnefil P, Zeng XL, Federoff HJ. Transsynaptic neuronal loss induced in hippocampal slice cultures by a herpes simplex virus vector expressing the GluR6 subunit of the kainate receptor. Proceedings of the National Academy of Sciences of the United States of America. 90: 6165-9. PMID 8392189 DOI: 10.1073/Pnas.90.13.6165  0.323
1993 Casaccia-Bonnefil P, Benedikz E, Shen H, Stelzer A, Edelstein D, Geschwind M, Brownlee M, Federoff HJ, Bergold PJ. Localized gene transfer into organotypic hippocampal slice cultures and acute hippocampal slices. Journal of Neuroscience Methods. 50: 341-51. PMID 8152244 DOI: 10.1016/0165-0270(93)90040-X  0.35
1992 Federoff HJ, Geschwind MD, Geller AI, Kessler JA. Expression of nerve growth factor in vivo from a defective herpes simplex virus 1 vector prevents effects of axotomy on sympathetic ganglia. Proceedings of the National Academy of Sciences of the United States of America. 89: 1636-40. PMID 1311846 DOI: 10.1073/Pnas.89.5.1636  0.371
1990 Grabczyk E, Zuber MX, Federoff HJ, Ng SC, Pack A, Fishman MC. Cloning and Characterization of the Rat Gene Encoding GAP-43. The European Journal of Neuroscience. 2: 822-827. PMID 12106089 DOI: 10.1111/J.1460-9568.1990.Tb00393.X  0.328
1989 De la Monte SM, Federoff HJ, Ng SC, Grabczyk E, Fishman MC. GAP-43 gene expression during development: persistence in a distinctive set of neurons in the mature central nervous system. Brain Research. Developmental Brain Research. 46: 161-8. PMID 2720952 DOI: 10.1016/0165-3806(89)90279-4  0.323
1980 Cohen JD, Eccleshall TR, Needleman RB, Federoff H, Buchferer BA, Marmur J. Functional expression in yeast of the Escherichia coli plasmid gene coding for chloramphenicol acetyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 77: 1078-82. PMID 6987664 DOI: 10.1073/Pnas.77.2.1078  0.307
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