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Allen D. Roses, MD - Publications

Affiliations: 
Medicine Duke University, Durham, NC 
Area:
http://www.researchprofiles.collexis.com/jad/expert.asp?u_id=26
Website:
http://medicine.duke.edu/faculty/details/0098535

205 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pytte J, Flynn LL, Anderton RS, Mastaglia FL, Theunissen F, James I, Pfaff A, Koks S, Saunders AM, Bedlack R, Burns DK, Lutz MW, Siddique N, Siddique T, Roses AD, et al. Disease-modifying effects of an structural variant in a predominantly ALS cohort. Neurology. Genetics. 6: e470. PMID 32754644 DOI: 10.1212/Nxg.0000000000000470  0.571
2018 Zietlow K, Charalambous L, Ng I, Gagrani S, Mihovilovic M, Luo S, Rock DL, Saunders A, Roses AD, Kirby Gottschalk W. Corrigendum to "The Biological Foundation of the Genetic Association of TOMM40 with Late-onset Alzheimer's disease" [Biochim. Biophys. Acta 1863/11 (2017) 2973-2986]. Biochimica Et Biophysica Acta. PMID 29395737 DOI: 10.1016/J.Bbadis.2018.01.017  0.399
2017 Nishimura A, Nonomura H, Tanaka S, Yoshida M, Maruyama Y, Aritomi Y, Saunders AM, Burns DK, Lutz MW, Runyan G, Lai E, Budur K, Roses AD. Characterization of APOE and TOMM40 allele frequencies in the Japanese population. Alzheimer's & Dementia (New York, N. Y.). 3: 524-530. PMID 29124110 DOI: 10.1016/J.Trci.2017.07.003  0.377
2017 Zeitlow K, Charlambous L, Ng I, Gagrani S, Mihovilovic M, Luo S, Rock DL, Saunders A, Roses AD, Kirby Gottschalk W. The Biological Foundation of the Genetic Association of TOMM40 with Late-onset Alzheimer's disease. Biochimica Et Biophysica Acta. PMID 28768149 DOI: 10.1016/J.Bbadis.2017.07.031  0.318
2017 Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Yang J, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans. Plos One. 12: e0180356. PMID 28672022 DOI: 10.1371/Journal.Pone.0180356  0.353
2017 Willette AA, Webb JL, Lutz MW, Bendlin BB, Wennberg AM, Oh JM, Roses A, Koscik RL, Hermann BP, Dowling NM, Asthana S, Johnson SC. Family history and TOMM40 '523 interactive associations with memory in middle-aged and Alzheimer's disease cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28549947 DOI: 10.1016/J.Jalz.2017.03.009  0.365
2017 Bonini NM, Lee EB, Wasco W, Roses AD. Editorial overview: Molecular & genetic basis of disease. Current Opinion in Genetics & Development. PMID 28473186 DOI: 10.1016/J.Gde.2017.04.003  0.313
2017 Larsen PA, Lutz MW, Hunnicutt KE, Mihovilovic M, Saunders AM, Yoder AD, Roses AD. The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28242298 DOI: 10.1016/J.Jalz.2017.01.017  0.304
2017 Yu L, Lutz MW, Wilson RS, Burns DK, Roses AD, Saunders AM, Gaiteri C, De Jager PL, Barnes LL, Bennett DA. TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype. Neurology. PMID 28108637 DOI: 10.1212/Wnl.0000000000003614  0.356
2017 Subramanian S, Gottschalk WK, Kim SY, Roses AD, Chiba-Falek O. The effects of PPARγ on the regulation of the TOMM40-APOE-C1 genes cluster. Biochimica Et Biophysica Acta. PMID 28065845 DOI: 10.1016/J.Bbadis.2017.01.004  0.31
2017 Willette AA, Webb JL, Lutz MW, Bendlin BB, Wennberg AM, Oh JM, Roses AD, Koscik RL, Hermann BP, Dowling M, Asthana S, Johnson SC. [IC-P-066]: AD FAMILY HISTORY MODULATES EFFECTS OF TOMM40 ‘523’ POLY-T ON MTL ATROPHY AND HYPOMETABOLISM IN PRECLINICAL AND AD COHORTS Alzheimer's & Dementia. 13: P54-P55. DOI: 10.1016/J.Jalz.2017.06.2339  0.302
2016 Saul R, Lutz MW, Burns DK, Roses AD, Chiba-Falek O. The SSV Evaluation System: A Tool to Prioritize Short Structural Variants for Studies of Possible Regulatory and Causal Variants. Human Mutation. PMID 27279261 DOI: 10.1002/Humu.23023  0.312
2016 Wennberg AM, Spira AP, Pettigrew C, Soldan A, Zipunnikov V, Rebok GW, Roses AD, Lutz MW, Miller MM, Thambisetty M, Albert MS. Blood glucose levels and cortical thinning in cognitively normal, middle-aged adults. Journal of the Neurological Sciences. 365: 89-95. PMID 27206882 DOI: 10.1016/J.Jns.2016.04.017  0.31
2016 Roses A, Sundseth S, Saunders A, Gottschalk W, Burns D, Lutz M. Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27154058 DOI: 10.1016/J.Jalz.2016.03.015  0.415
2016 Gottschalk WK, Mihovilovic M, Roses AD, Chiba-Falek O. The Role of Upregulated APOE in Alzheimer's Disease Etiology. Journal of Alzheimer's Disease & Parkinsonism. 6. PMID 27104063 DOI: 10.4172/2161-0460.1000209  0.385
2016 Lutz MW, Sundseth SS, Burns DK, Saunders AM, Hayden KM, Burke JR, Welsh-Bohmer KA, Roses AD. A Genetics-based Biomarker Risk Algorithm for Predicting Risk of Alzheimer's Disease. Alzheimer's & Dementia : Translational Research & Clinical Interventions. 2: 30-44. PMID 27047990 DOI: 10.1016/J.Trci.2015.12.002  0.367
2016 Lutz MW, Crenshaw D, Welsh-Bohmer KA, Burns DK, Roses AD. New Genetic Approaches to AD: Lessons from APOE-TOMM40 Phylogenetics. Current Neurology and Neuroscience Reports. 16: 48. PMID 27039903 DOI: 10.1007/S11910-016-0643-8  0.366
2016 Roses AD, Akkari PA, Chiba-Falek O, Lutz MW, Gottschalk WK, Saunders AM, Saul B, Sundseth S, Burns D. Structural variants can be more informative for disease diagnostics, prognostics and translation than current SNP mapping and exon sequencing. Expert Opinion On Drug Metabolism & Toxicology. PMID 26727306 DOI: 10.1517/17425255.2016.1133586  0.304
2016 Charalambous LT, Ng I, Mihovilovic M, Saunders AM, Roses AD, Gottschalk WK. Tomm40 Overexpression And Ppar-Gamma Agonists Protect Cells From Pathophysiological Stress Associated With Late Onset Alzheimer'S Disease Alzheimers & Dementia. 12: 1149. DOI: 10.1016/J.Jalz.2016.07.044  0.341
2016 Weninger S, Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman R, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo M. F4-03-01: Collaboration for Alzheimer's Prevention (CAP): Advancing the Evaluation of Preclinical Alzheimer's Disease Treatments Alzheimer's & Dementia. 12: P325-P326. DOI: 10.1016/J.Jalz.2016.06.596  0.346
2016 Willette AA, Webb JL, Lutz MW, Wennberg AMV, Roses AD, Johnson SC, Bendlin BB. Alzheimer'S Disease Family History Modulates Effects Of '523 Tomm40 On Memory Decline And Medial Temporal Pathology Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1280  0.338
2016 Webb JL, Lutz MW, Wennberg AM, Roses AD, Johnson SC, Bendlin BB, Willette AA. IC-P-068: Family History Modulates TOMM40's Effect on Alzheimer's Disease Vascular Risk Factors and Neurodegeneration Alzheimer's & Dementia. 12: P54-P54. DOI: 10.1016/J.Jalz.2016.06.098  0.333
2015 Roses AD. Polyallelic structural variants can provide accurate, highly informative genetic markers focused on diagnosis and therapeutic targets: Accuracy versus precision. Clinical Pharmacology and Therapeutics. PMID 26517180 DOI: 10.1002/Cpt.288  0.305
2015 Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S. CAP-advancing the evaluation of preclinical Alzheimer disease treatments. Nature Reviews. Neurology. PMID 26416539 DOI: 10.1038/Nrneurol.2015.177  0.339
2015 Lyall DM, Muñoz Maniega S, Harris SE, Bastin ME, Murray C, Lutz MW, Saunders AM, Roses AD, Valdés Hernández MD, Royle NA, Starr JM, Porteous DJ, Deary IJ, Wardlaw JM. APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds. International Journal of Stroke : Official Journal of the International Stroke Society. PMID 26310205 DOI: 10.1111/Ijs.12615  0.331
2015 Lutz MW, Saul R, Linnertz C, Glenn OC, Roses AD, Chiba-Falek O. A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 1133-43. PMID 26079410 DOI: 10.1016/J.Jalz.2015.05.011  0.401
2015 Roses AD. APOE and TOMM40 in Alzheimer's Disease: A Case of Mistaken Identity, Using Precision Tools but with Loss of Accuracy Journal of Pharmacogenomics and Pharmacoproteomics. 6. DOI: 10.4172/2153-0645.1000E148  0.378
2014 Gottschalk WK, Lutz MW, He YT, Saunders AM, Burns DK, Roses AD, Chiba-Falek O. The Broad Impact of TOM40 on Neurodegenerative Diseases in Aging. Journal of Parkinson's Disease and Alzheimer's Disease. 1. PMID 25745640 DOI: 10.13188/2376-922X.1000003  0.328
2014 Roses AD, Lutz MW, Saunders AM, Goldgaber D, Saul R, Sundseth SS, Akkari PA, Roses SM, Gottschalk WK, Whitfield KE, Vostrov AA, Hauser MA, Allingham RR, Burns DK, Chiba-Falek O, et al. African-American TOMM40'523-APOE haplotypes are admixture of West African and Caucasian alleles. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 592-601.e2. PMID 25260913 DOI: 10.1016/J.Jalz.2014.06.009  0.334
2014 Greenbaum L, Springer RR, Lutz MW, Heymann A, Lubitz I, Cooper I, Kravitz E, Sano M, Roses AD, Silverman JM, Saunders AM, Beeri MS. The TOMM40 poly-T rs10524523 variant is associated with cognitive performance among non-demented elderly with type 2 diabetes. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 1492-9. PMID 25044051 DOI: 10.1016/J.Euroneuro.2014.06.002  0.301
2014 Linnertz C, Lutz MW, Ervin JF, Allen J, Miller NR, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease. Human Molecular Genetics. 23: 4814-21. PMID 24777780 DOI: 10.1093/Hmg/Ddu196  0.377
2014 Romero HR, Welsh-Bohmer KA, Gwyther LP, Edmonds HL, Plassman BL, Germain CM, McCart M, Hayden KM, Pieper C, Roses AD. Community engagement in diverse populations for Alzheimer disease prevention trials. Alzheimer Disease and Associated Disorders. 28: 269-74. PMID 24614272 DOI: 10.1097/Wad.0000000000000029  0.309
2014 Roses AD, Saunders AM, Lutz MW, Zhang N, Hariri AR, Asin KE, Crenshaw DG, Budur K, Burns DK, Brannan SK. New applications of disease genetics and pharmacogenetics to drug development. Current Opinion in Pharmacology. 14: 81-9. PMID 24565016 DOI: 10.1016/J.Coph.2013.12.002  0.311
2014 Lyall DM, Harris SE, Bastin ME, Muñoz Maniega S, Murray C, Lutz MW, Saunders AM, Roses AD, Valdés Hernández Mdel C, Royle NA, Starr JM, Porteous DJ, Wardlaw JM, Deary IJ. Alzheimer's disease susceptibility genes APOE and TOMM40, and brain white matter integrity in the Lothian Birth Cohort 1936. Neurobiology of Aging. 35: 1513.e25-33. PMID 24508314 DOI: 10.1016/J.Neurobiolaging.2014.01.006  0.366
2014 Linnertz C, Anderson L, Gottschalk W, Crenshaw D, Lutz MW, Allen J, Saith S, Mihovilovic M, Burke JR, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. The cis-regulatory effect of an Alzheimer's disease-associated poly-T locus on expression of TOMM40 and apolipoprotein E genes. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 541-51. PMID 24439168 DOI: 10.1016/J.Jalz.2013.08.280  0.615
2014 Lutz MW, Saul R, Burns D, Saunders A, Roses A. P3-021: IDENTIFICATION AND CHARACTERIZATION OF POLYMORPHIC STRUCTURAL VARIANTS ASSOCIATED WITH ALZHEIMER'S DISEASE AND DISEASES OF AGING Alzheimer's & Dementia. 10: P635-P635. DOI: 10.1016/J.Jalz.2014.05.1108  0.34
2013 Lyall DM, Royle NA, Harris SE, Bastin ME, Maniega SM, Murray C, Lutz MW, Saunders AM, Roses AD, del Valdés Hernández MC, Starr JM, Porteous DJ, Wardlaw JM, Deary IJ. Alzheimer's disease susceptibility genes APOE and TOMM40, and hippocampal volumes in the Lothian birth cohort 1936. Plos One. 8: e80513. PMID 24260406 DOI: 10.1371/Journal.Pone.0080513  0.352
2013 Roses AD, Lutz MW, Crenshaw DG, Grossman I, Saunders AM, Gottschalk WK. TOMM40 and APOE: Requirements for replication studies of association with age of disease onset and enrichment of a clinical trial. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 132-6. PMID 23333464 DOI: 10.1016/J.Jalz.2012.10.009  0.392
2013 Crenshaw DG, Gottschalk WK, Lutz MW, Grossman I, Saunders AM, Burke JR, Welsh-Bohmer KA, Brannan SK, Burns DK, Roses AD. Using genetics to enable studies on the prevention of Alzheimer's disease. Clinical Pharmacology and Therapeutics. 93: 177-85. PMID 23249780 DOI: 10.1038/Clpt.2012.222  0.404
2013 Lutz M, Ogrinc F, Burns D, Saunders A, Roses A. P4-352: Performance of a genetics-based biomarker risk algorithm to support a clinical trial to delay onset of mild cognitive impairment due to Alzheimer's disease Alzheimer's & Dementia. 9: P860-P861. DOI: 10.1016/J.Jalz.2013.08.186  0.328
2012 Caselli RJ, Dueck AC, Huentelman MJ, Lutz MW, Saunders AM, Reiman EM, Roses AD. Longitudinal modeling of cognitive aging and the TOMM40 effect. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 490-5. PMID 23102119 DOI: 10.1016/J.Jalz.2011.11.006  0.366
2012 Chiba-Falek O, Linnertz C, Guyton J, Gardner SD, Roses AD, McCarthy JJ, Patel K. Pleiotropy and allelic heterogeneity in the TOMM40-APOE genomic region related to clinical and metabolic features of hepatitis C infection. Human Genetics. 131: 1911-20. PMID 22898894 DOI: 10.1007/S00439-012-1220-0  0.329
2012 Hayden KM, McEvoy JM, Linnertz C, Attix D, Kuchibhatla M, Saunders AM, Lutz MW, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 381-8. PMID 22863908 DOI: 10.1016/J.Jalz.2011.10.005  0.356
2012 Linnertz C, Saunders AM, Lutz MW, Crenshaw DM, Grossman I, Burns DK, Whitfield KE, Hauser MA, McCarthy JJ, Ulmer M, Allingham R, Welsh-Bohmer KA, Roses AD, Chiba-Falek O. Characterization of the poly-T variant in the TOMM40 gene in diverse populations. Plos One. 7: e30994. PMID 22359560 DOI: 10.1371/Journal.Pone.0030994  0.323
2012 Roses AD. Post-GWAS: Phylogenetic Analysis in the Hunt for Complex Disease- Associated Loci Journal of Pharmacogenomics & Pharmacoproteomics. 3. DOI: 10.4172/2153-0645.1000E120  0.334
2012 Lutz M, Crenshaw D, Saunders A, Chiba-Falek O, Gottschalk K, Burns D, Grossman I, Roses A. P4-122: TOMM40-APOE regulatory haplotype and age of onset of late-onset Alzheimer's disease Alzheimer's & Dementia. 8: P674-P674. DOI: 10.1016/J.Jalz.2012.05.1825  0.39
2011 Johnson SC, La Rue A, Hermann BP, Xu G, Koscik RL, Jonaitis EM, Bendlin BB, Hogan KJ, Roses AD, Saunders AM, Lutz MW, Asthana S, Green RC, Sager MA. The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 456-65. PMID 21784354 DOI: 10.1016/J.Jalz.2010.11.012  0.342
2011 Roses AD, Crenshaw D, Saunders A. PPARgamma Agonists and Alzheimer's Disease: The Use of TOMM40 polyT Length Variations in Pharmacogenetic-Assisted Clinical Trial Designs Annual Review of Pharmacology and Toxicology. 52: 110301101444027. DOI: 10.1146/Annurev-Pharmtox-010510-100543  0.332
2011 Hayden K, Lutz M, Saunders A, Romero H, Burke J, Welsh-Bohmer K, Roses A. P1-235: TOMM40 “523” Genotype Affects Age of Alzheimer's Disease Onset Differentially by Race Alzheimer's & Dementia. 7: S186-S186. DOI: 10.1016/J.Jalz.2011.05.515  0.378
2010 Grossman I, Lutz MW, Crenshaw DG, Saunders AM, Burns DK, Roses AD. Alzheimer's disease: diagnostics, prognostics and the road to prevention. The Epma Journal. 1: 293-303. PMID 21124753 DOI: 10.1007/S13167-010-0024-3  0.396
2010 Lutz MW, Crenshaw DG, Saunders AM, Roses AD. Genetic variation at a single locus and age of onset for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 125-31. PMID 20298972 DOI: 10.1016/J.Jalz.2010.01.011  0.406
2010 Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA, Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P, Albert MS, Breitner JC, et al. Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 89-97. PMID 20298968 DOI: 10.1016/J.Jalz.2010.01.008  0.324
2010 Heinzen EL, Need AC, Hayden KM, Chiba-Falek O, Roses AD, Strittmatter WJ, Burke JR, Hulette CM, Welsh-Bohmer KA, Goldstein DB. Genome-wide scan of copy number variation in late-onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 19: 69-77. PMID 20061627 DOI: 10.3233/JAD-2010-1212  0.598
2010 Caselli RJ, Saunders A, Lutz M, Huentelman M, Reiman E, Roses A. P1-096: TOMM40, APOE, and age of onset of Alzheimer's disease Alzheimer's & Dementia. 6: S202-S202. DOI: 10.1016/J.Jalz.2010.05.644  0.382
2009 Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, KasperaviciÅ«te D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, ... ... Roses AD, et al. A genome-wide investigation of SNPs and CNVs in schizophrenia. Plos Genetics. 5: e1000373. PMID 19197363 DOI: 10.1371/Journal.Pgen.1000373  0.555
2009 Roses AD. The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 6-17. PMID 18923406 DOI: 10.1038/Npp.2008.153  0.31
2009 Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, Shianna KV, Yoon W, Kasperavičiūtė D, Gennarelli M, Strittmatter WJ, Bonvicini C, Rossi G, Jayathilake K, Cola PA, ... ... Roses AD, et al. Correction: A Genome-Wide Investigation of SNPs and CNVs in Schizophrenia Plos Genetics. 5. DOI: 10.1371/Annotation/E0196Ebb-De40-453F-8F8C-791B126618Da  0.523
2009 Roses AD, Lutz MW, Huentelman MJ, Chiba-Falek O, Welsh-Bohmer KA, Reiman EM. O1-06-01: Apoeϵ3 A3 nd Tomm-40 Haplotypes Determine Inheritance of Alzheimer's Disease Independently of Apoeϵ4 Risk Alzheimer's & Dementia. 5: e1-e1. DOI: 10.1016/J.Jalz.2009.07.119  0.329
2008 Akuffo EL, Davis JB, Fox SM, Gloger IS, Hosford D, Kinsey EE, Jones NA, Nock CM, Roses AD, Saunders AM, Skehel JM, Smith MA, Cutler P. The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 13: 618-36. PMID 18830857 DOI: 10.1080/13547500802445199  0.377
2008 Roses AD. Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium." An impending prevention clinical trial for Alzheimer's disease: roadmaps and realities. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 164-6. PMID 18631961 DOI: 10.1016/J.Jalz.2008.03.007  0.308
2008 Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proceedings of the National Academy of Sciences of the United States of America. 105: 1343-6. PMID 18212130 DOI: 10.1073/Pnas.0709906104  0.331
2008 Li H, Wetten S, Li L, St Jean PL, Upmanyu R, Surh L, Hosford D, Barnes MR, Briley JD, Borrie M, Coletta N, Delisle R, Dhalla D, Ehm MG, Feldman HH, ... ... Roses AD, et al. Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease. Archives of Neurology. 65: 45-53. PMID 17998437 DOI: 10.1001/Archneurol.2007.3  0.376
2006 Roses AD. On the discovery of the genetic association of Apolipoprotein E genotypes and common late-onset Alzheimer disease. Journal of Alzheimer's Disease : Jad. 9: 361-6. PMID 16914873  0.348
2004 Hosford DA, Lai EH, Riley JH, Xu CF, Danoff TM, Roses AD. Pharmacogenetics to predict drug-related adverse events. Toxicologic Pathology. 32: 9-12. PMID 15209398 DOI: 10.1080/01926230490424743  0.327
2004 Quan H, Haines JL, Sanchez-Boutard N, Small G, Roses A, Schmechel D, Welsh-Bohmer K, Xu P, Li Y, Gilbert JR, Vance JM, Pericak-Vance MA. P4-138 Genomic convergence on chromosome 12 in Alzheimer's disease Neurobiology of Aging. 25: S514. DOI: 10.1016/S0197-4580(04)81696-8  0.336
2004 Li Y, Oliveira SA, Qin X, Roses AD, Schmechel D, Welsh-Bohmer KA, Haines JL, Pericak-Vance MA, Vance JM. P4-088 Association analysis of interleukin 1 (IL-1) polymorphisms with age-at-onset and risk of Alzheimer disease Neurobiology of Aging. 25: S499. DOI: 10.1016/S0197-4580(04)81646-4  0.323
2004 Pericak-Vance MA, Bronson P, Martin ER, Browning C, Rayner M, Xu P, Small GW, Roses AD, Schmechel DE, Doraiswamy PM, Welsh-Bohmer KA, Haines JL, Gilbert JR. P4-080 Genetic studies of Alzheimer disease on chromosome 9P Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81638-5  0.335
2000 Riley JH, Allan CJ, Lai E, Roses A. The use of single nucleotide polymorphisms in the isolation of common disease genes. Pharmacogenomics. 1: 39-47. PMID 11258595 DOI: 10.1517/14622416.1.1.39  0.361
2000 Saunders AM, Trowers MK, Shimkets RA, Blakemore S, Crowther DJ, Mansfield TA, Wallace DM, Strittmatter WJ, Roses AD. The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection. Biochimica Et Biophysica Acta. 1502: 85-94. PMID 10899434 DOI: 10.1016/S0925-4439(00)00035-1  0.628
2000 Martin ER, Lai EH, Gilbert JR, Rogala AR, Afshari AJ, Riley J, Finch KL, Stevens JF, Livak KJ, Slotterbeck BD, Slifer SH, Warren LL, Conneally PM, Schmechel DE, Purvis I, ... ... Roses AD, et al. SNPing away at complex diseases: analysis of single-nucleotide polymorphisms around APOE in Alzheimer disease. American Journal of Human Genetics. 67: 383-94. PMID 10869235 DOI: 10.1086/303003  0.383
2000 Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, ... ... Roses AD, et al. Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 97: 6037-42. PMID 10811879 DOI: 10.1073/Pnas.090106797  0.331
2000 Riley KP, Snowdon DA, Saunders AM, Roses AD, Mortimer JA, Nanayakkara N. Cognitive function and apolipoprotein E in very old adults: findings from the Nun Study. The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences. 55: S69-75. PMID 10794191 DOI: 10.1093/Geronb/55.2.S69  0.326
2000 Martin ER, Gilbert JR, Lai EH, Riley J, Rogala AR, Slotterbeck BD, Sipe CA, Grubber JM, Warren LL, Conneally PM, Saunders AM, Schmechel DE, Purvis I, Pericak-Vance MA, Roses AD, et al. Analysis of association at single nucleotide polymorphisms in the APOE region. Genomics. 63: 7-12. PMID 10662539 DOI: 10.1006/Geno.1999.6057  0.341
1999 Small GW, Scott WK, Komo S, Yamaoka LH, Farrer LA, Auerbach SH, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA. No association between the HLA-A2 allele and Alzheimer disease. Neurogenetics. 2: 177-82. PMID 10541592 DOI: 10.1007/S100480050080  0.327
1999 Grubber JM, Saunders AM, Crane-Gatherum AR, Scott WK, Martin ER, Haynes CS, Conneally PM, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). Neuroscience Letters. 269: 115-9. PMID 10430518 DOI: 10.1016/S0304-3940(99)00426-7  0.317
1999 Rogaeva EA, Premkumar S, Grubber J, Serneels L, Scott WK, Kawarai T, Song Y, Hill DL, Abou-Donia SM, Martin ER, Vance JJ, Yu G, Orlacchio A, Pei Y, Nishimura M, ... ... Roses AD, et al. An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. Nature Genetics. 22: 19-22. PMID 10319855 DOI: 10.1038/8729  0.383
1998 Cooper AJ, Sheu KF, Burke JR, Onodera O, Strittmatter WJ, Roses AD, Blass JP. Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly-Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions? Age. 21: 25-30. PMID 23604331 DOI: 10.1007/S11357-998-0004-X  0.641
1998 Scott WK, Yamaoka LH, Bass MP, Gaskell PC, Conneally PM, Small GW, Farrer LA, Auerbach SA, Saunders AM, Roses AD, Haines JL, Pericak-Vance MA. No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease. Neurogenetics. 1: 179-83. PMID 10737120 DOI: 10.1007/S100480050026  0.399
1998 Roses AD. Apolipoprotein E and Alzheimer's disease. The tip of the susceptibility iceberg. Annals of the New York Academy of Sciences. 855: 738-43. PMID 9929679  0.3
1998 Einstein G, Patel V, Bautista P, Kenna M, Melone L, Fader R, Karson K, Mann S, Saunders AM, Hulette C, Mash D, Roses AD, Schmechel DE. Intraneuronal ApoE in human visual cortical areas reflects the staging of Alzheimer disease pathology. Journal of Neuropathology and Experimental Neurology. 57: 1190-201. PMID 9862642 DOI: 10.1097/00005072-199812000-00011  0.372
1998 Farrer LA, Abraham CR, Haines JL, Rogaeva EA, Song Y, McGraw WT, Brindle N, Premkumar S, Scott WK, Yamaoka LH, Saunders AM, Roses AD, Auerbach SA, Sorbi S, Duara R, et al. Association between bleomycin hydrolase and Alzheimer's disease in caucasians. Annals of Neurology. 44: 808-11. PMID 9818937 DOI: 10.1002/Ana.410440515  0.403
1998 Bass MP, Yamaoka LH, Scott WK, Gaskell PC, Welsh-Bohmer KA, Roses AD, Saunders AM, Haines JL, Pericak-Vance MA. No association of alpha1-antichymotrypsin flanking region polymorphism and Alzheimer disease risk in early- and late-onset Alzheimer disease patients. Neuroscience Letters. 250: 79-82. PMID 9697923 DOI: 10.1016/S0304-3940(98)00398-X  0.4
1998 Mihovilovic M, Denning S, Mai Y, Fisher CM, Whichard LP, Patel DD, Roses AD. Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5, and beta-4 subunits of neuronal nicotinic acetylcholine receptors. Preferential transcription of the alpha-3 and beta-4 genes by immature CD4+8+ thymocytes and evidence for response to nicotine in thymocytes. Annals of the New York Academy of Sciences. 841: 388-92. PMID 9668263 DOI: 10.1111/J.1749-6632.1998.Tb10951.X  0.458
1998 Thomas AM, Cohen G, Cook-Deegan RM, O'Sullivan J, Post SG, Roses AD, Schaffner KF, Green RM. Alzheimer testing at Silver Years. Cambridge Quarterly of Healthcare Ethics : Cq : the International Journal of Healthcare Ethics Committees. 7: 294-307. PMID 9663350 DOI: 10.1017/S096318019870310X  0.34
1998 Scott BL, Welch K, deSerrano V, Moss NC, Roses AD, Strittmatter WJ. Human apolipoprotein E accelerates microtubule polymerization in vitro. Neuroscience Letters. 245: 105-8. PMID 9605496 DOI: 10.1016/S0304-3940(98)00180-3  0.62
1998 Laskowitz DT, Horsburgh K, Roses AD. Apolipoprotein E and the CNS response to injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 465-71. PMID 9591838 DOI: 10.1097/00004647-199805000-00001  0.408
1998 Sheng H, Laskowitz DT, Bennett E, Schmechel DE, Bart RD, Saunders AM, Pearlstein RD, Roses AD, Warner DS. Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 18: 361-6. PMID 9538900 DOI: 10.1097/00004647-199804000-00003  0.303
1998 Guyton JR, Miller SE, Martin ME, Khan WA, Roses AD, Strittmatter WJ. Novel large apolipoprotein E-containing lipoproteins of density 1.006-1.060 g/ml in human cerebrospinal fluid. Journal of Neurochemistry. 70: 1235-40. PMID 9489746 DOI: 10.1046/J.1471-4159.1998.70031235.X  0.569
1998 Mayeux R, Saunders AM, Shea S, Mirra S, Evans D, Roses AD, Hyman BT, Crain B, Tang MX, Phelps CH. Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease. The New England Journal of Medicine. 338: 506-11. PMID 9468467 DOI: 10.1056/Nejm199802193380804  0.436
1998 Cooper AJL, Sheu KFR, Burke JR, Onodera O, Strittmatter WJ, Roses AD, Blass JP. Inhibition of α-ketoglutarate-and pyruvate dehydrogenase complexes in E. coli by a glutathione S-transferase containing a pathological length poly- Q domain: A possible role of energy deficit in neurological diseases associated with poly-Q expansions? Age. 21: 25-30.  0.547
1997 Roses AD. A model for susceptibility polymorphisms for complex diseases: apolipoprotein E and Alzheimer disease. Neurogenetics. 1: 3-11. PMID 10735268 DOI: 10.1007/S100480050001  0.423
1997 Roses AD, Saunders AM. Apolipoprotein E genotyping as a diagnostic adjunct for Alzheimer's disease. International Psychogeriatrics / Ipa. 9: 277-88; discussion 3. PMID 9447448 DOI: 10.1017/S1041610297005012  0.414
1997 Cooper AJ, Sheu KR, Burke JR, Onodera O, Strittmatter WJ, Roses AD, Blass JP. Transglutaminase-catalyzed inactivation of glyceraldehyde 3-phosphate dehydrogenase and alpha-ketoglutarate dehydrogenase complex by polyglutamine domains of pathological length. Proceedings of the National Academy of Sciences of the United States of America. 94: 12604-9. PMID 9356496 DOI: 10.1073/Pnas.94.23.12604  0.588
1997 Roses AD. Genetic testing for Alzheimer disease. Practical and ethical issues. Archives of Neurology. 54: 1226-9. PMID 9341568 DOI: 10.1001/Archneur.1997.00550220036011  0.419
1997 Pericak-Vance MA, Bass MP, Yamaoka LH, Gaskell PC, Scott WK, Terwedow HA, Menold MM, Conneally PM, Small GW, Vance JM, Saunders AM, Roses AD, Haines JL. Complete genomic screen in late-onset familial Alzheimer disease. Evidence for a new locus on chromosome 12. Jama. 278: 1237-41. PMID 9333264 DOI: 10.1001/Jama.1997.03550150041033  0.389
1997 Roses AD, Saunders AM. ApoE, Alzheimer's disease, and recovery from brain stress. Annals of the New York Academy of Sciences. 826: 200-12. PMID 9329691 DOI: 10.1111/J.1749-6632.1997.Tb48471.X  0.41
1997 Tardiff BE, Newman MF, Saunders AM, Strittmatter WJ, Blumenthal JA, White WD, Croughwell ND, Davis RD, Roses AD, Reves JG. Preliminary report of a genetic basis for cognitive decline after cardiac operations. The Neurologic Outcome Research Group of the Duke Heart Center. The Annals of Thoracic Surgery. 64: 715-20. PMID 9307463 DOI: 10.1016/S0003-4975(97)00757-1  0.568
1997 Welsh-Bohmer KA, Gearing M, Saunders AM, Roses AD, Mirra S. Apolipoprotein E genotypes in a neuropathological series from the Consortium to Establish a Registry for Alzheimer's Disease. Annals of Neurology. 42: 319-25. PMID 9307253 DOI: 10.1002/Ana.410420308  0.388
1997 Onodera O, Burke JR, Miller SE, Hester S, Tsuji S, Roses AD, Strittmatter WJ. Oligomerization of expanded-polyglutamine domain fluorescent fusion proteins in cultured mammalian cells. Biochemical and Biophysical Research Communications. 238: 599-605. PMID 9299559 DOI: 10.1006/Bbrc.1997.7337  0.594
1997 Roses AD. Alzheimer's disease: the genetics of risk. Hospital Practice (1995). 32: 51-5, 58-63, 67-9. PMID 9227658 DOI: 10.1080/21548331.1997.11443525  0.39
1997 Alexander GE, Saunders AM, Szczepanik J, Strassburger TL, Pietrini P, Dani A, Furey ML, Mentis MJ, Roses AD, Rapoport SI, Schapiro MB. Relation of age and apolipoprotein E to cognitive function in Down syndrome adults. Neuroreport. 8: 1835-40. PMID 9223061 DOI: 10.1097/00001756-199705260-00009  0.344
1997 Cooper AJ, Sheu KF, Burke JR, Onodera O, Strittmatter WJ, Roses AD, Blass JP. Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? Journal of Neurochemistry. 69: 431-4. PMID 9202340 DOI: 10.1046/J.1471-4159.1997.69010431.X  0.59
1997 Post SG, Whitehouse PJ, Binstock RH, Bird TD, Eckert SK, Farrer LA, Fleck LM, Gaines AD, Juengst ET, Karlinsky H, Miles S, Murray TH, Quaid KA, Relkin NR, Roses AD, et al. The clinical introduction of genetic testing for Alzheimer disease. An ethical perspective. Jama. 277: 832-6. PMID 9052715 DOI: 10.1001/Jama.1997.03540340066035  0.372
1996 Strittmatter WJ, Burke JR, DeSerrano VS, Huang DY, Matthew W, Saunders AM, Scott BL, Vance JM, Weisgraber KH, Roses AD. Protein: protein interactions in Alzheimer's disease and the CAG triplet repeat diseases. Cold Spring Harbor Symposia On Quantitative Biology. 61: 597-605. PMID 9246486 DOI: 10.1101/Sqb.1996.061.01.060  0.759
1996 Small GW, Komo S, La Rue A, Saxena S, Phelps ME, Mazziotta JC, Saunders AM, Haines JL, Pericak-Vance MA, Roses AD. Early detection of Alzheimer's disease by combining apolipoprotein E and neuroimaging. Annals of the New York Academy of Sciences. 802: 70-8. PMID 8993486 DOI: 10.1111/J.1749-6632.1996.Tb32600.X  0.399
1996 Roses AD. Apolipoprotein E and Alzheimer's disease. A rapidly expanding field with medical and epidemiological consequences. Annals of the New York Academy of Sciences. 802: 50-7. PMID 8993484 DOI: 10.1111/J.1749-6632.1996.Tb32598.X  0.406
1996 Haines JL, Pritchard ML, Saunders AM, Schildkraut JM, Growdon JH, Gaskell PC, Farrer LA, Auerbach SA, Gusella JF, Locke PA, Rosi BL, Yamaoka L, Small GW, Conneally PM, Roses AD, et al. No association between alpha 1-antichymotrypsin and familial Alzheimer's disease. Annals of the New York Academy of Sciences. 802: 35-41. PMID 8993482 DOI: 10.1111/J.1749-6632.1996.Tb32596.X  0.39
1996 Onodera O, Roses AD, Tsuji S, Vance JM, Strittmatter WJ, Burke JR. Toxicity of expanded polyglutamine-domain proteins in Escherichia coli. Febs Letters. 399: 135-9. PMID 8980137 DOI: 10.1016/S0014-5793(96)01301-4  0.561
1996 Roses AD, Bryan J, Bryan K. Apolipoprotein E genotype: utility in clinical practice in Alzheimer's disease. Journal of the American Geriatrics Society. 44: 1479-81. PMID 8951322 DOI: 10.1111/J.1532-5415.1996.Tb04077.X  0.391
1996 Roses AD. The Alzheimer diseases. Current Opinion in Neurobiology. 6: 644-50. PMID 8937829 DOI: 10.1016/S0959-4388(96)80098-5  0.424
1996 Roses AD. Apolipoprotein E in neurology. Current Opinion in Neurology. 9: 265-70. PMID 8858183 DOI: 10.1097/00019052-199608000-00004  0.367
1996 Strittmatter WJ, Roses AD. Apolipoprotein E and Alzheimer's disease. Annual Review of Neuroscience. 19: 53-77. PMID 8833436 DOI: 10.1146/Annurev.Ne.19.030196.000413  0.66
1996 Okuizumi K, Onodera O, Seki K, Tanaka H, Namba Y, Ikeda K, Saunders AM, Pericak-Vance MA, Roses AD, Tsuji S. Lack of association of very low density lipoprotein receptor gene polymorphism with Caucasian Alzheimer's disease. Annals of Neurology. 40: 251-4. PMID 8773610 DOI: 10.1002/Ana.410400220  0.381
1996 Xia Y, Rohan de Silva HA, Rosi BL, Yamaoka LH, Rimmler JB, Pericak-Vance MA, Roses AD, Chen X, Masliah E, DeTeresa R, Iwai A, Sundsmo M, Thomas RG, Hofstetter CR, Gregory E, et al. Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism. Annals of Neurology. 40: 207-15. PMID 8773602 DOI: 10.1002/Ana.410400212  0.438
1996 Roses AD, Einstein G, Gilbert J, Goedert M, Han SH, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi PT. Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Annals of the New York Academy of Sciences. 777: 146-57. PMID 8624078 DOI: 10.1111/J.1749-6632.1996.Tb34413.X  0.681
1996 Burke JR, Enghild JJ, Martin ME, Jou YS, Myers RM, Roses AD, Vance JM, Strittmatter WJ. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Medicine. 2: 347-50. PMID 8612237 DOI: 10.1038/Nm0396-347  0.615
1996 Corder EH, Roses AD. No increased risk of the apolipoprotein E epsilon2 allele with early-onset Alzheimer's disease. Annals of Neurology. 39: 414-6. PMID 8602768 DOI: 10.1002/Ana.410390327  0.408
1996 Roses AD, Burke JR, Vance JM, Strittmatter WJ. Reply to “A role for GAPDH in apoptosis and neurodegeneration” Nature Medicine. 2: 610-610. DOI: 10.1038/Nm0696-610A  0.51
1996 Roses A, Saunders A, Hulette C, Welsh K, Crain B, Burke J, Alberts M, Strittmatter W, Breitner J, Earl N, Clark C, Heyman A, Gaskell P, Pericak-Vance M. 295 Predictive value of APOE genotyping in a consecutive series of autopsied sporadic probable Alzheimer disease patients Neurobiology of Aging. 17: S74. DOI: 10.1016/S0197-4580(96)80297-1  0.586
1996 Roses A, Saunders A, Pericak-Vance M, Einstein G, Hulette C, Schmechel D, Huang D, Strittmatter W. Apolipoprotein is a susceptibility genetic locus that affects the expression of late-onset familial and sporadic Alzheimer's disease Biological Psychiatry. 39: 562. DOI: 10.1016/0006-3223(96)84162-X  0.672
1995 Breitner JC, Welsh KA, Helms MJ, Gaskell PC, Gau BA, Roses AD, Pericak-Vance MA, Saunders AM. Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs. Neurobiology of Aging. 16: 523-30. PMID 8544901 DOI: 10.1016/0197-4580(95)00049-K  0.337
1995 Roses AD, Saunders AM, Alberts MA, Strittmatter WJ, Schmechel D, Gorder E, Pericak-Vance MA. Apolipoprotein E E4 allele and risk of dementia. Jama. 273: 374-5; author reply . PMID 7823377 DOI: 10.1001/Jama.1995.03520290026015  0.623
1995 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Roses AD, Pericak-Vance MA, Small GW, Haines JL. The apolipoprotein E E4 allele and sex-specific risk of Alzheimer's disease. Jama. 273: 373-4. PMID 7823376 DOI: 10.1001/jama.1995.03520290025013  0.594
1995 Roses AD, Saunders AM, Strittmatter WJ, Schmechel DE, Pericak-Vance MA, Hyman B. Apolipoprotein E in Creutzfeldt-Jacob disease. Lancet. 345: 69. PMID 7799733  0.576
1995 Roses AD. On the metabolism of apolipoprotein E and the Alzheimer diseases. Experimental Neurology. 132: 149-56. PMID 7789455 DOI: 10.1016/0014-4886(95)90019-5  0.375
1995 Roses AD, Saunders AM, Corder EH, Pericak-Vance MA, Han SH, Einstein G, Hulette C, Schmechel DE, Holsti M, Huang D. Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease. Arzneimittel-Forschung. 45: 413-7. PMID 7763336  0.537
1995 Strittmatter WJ, Roses AD. Apolipoprotein E and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 92: 4725-7. PMID 7761390 DOI: 10.1073/pnas.92.11.4725  0.642
1995 Alberts MJ, Graffagnino C, McClenny C, DeLong D, Strittmatter W, Saunders AM, Roses AD. ApoE genotype and survival from intracerebral haemorrhage. Lancet. 346: 575. PMID 7658797 DOI: 10.1016/S0140-6736(95)91411-0  0.51
1995 Corder EH, Saunders AM, Pericak-Vance MA, Roses AD. There is a pathologic relationship between ApoE-epsilon 4 and Alzheimer's disease. Archives of Neurology. 52: 650-1. PMID 7619017 DOI: 10.1001/Archneur.1995.00540310012003  0.403
1995 Roses AD. Apolipoprotein E genotyping in the differential diagnosis, not prediction, of Alzheimer's disease. Annals of Neurology. 38: 6-14. PMID 7611727 DOI: 10.1002/Ana.410380105  0.389
1995 Chen X, de Silva HA, Pettenati MJ, Rao PN, St George-Hyslop P, Roses AD, Xia Y, Horsburgh K, Uéda K, Saitoh T. The human NACP/alpha-synuclein gene: chromosome assignment to 4q21.3-q22 and TaqI RFLP analysis. Genomics. 26: 425-7. PMID 7601479 DOI: 10.1016/0888-7543(95)80237-G  0.368
1995 Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, Tsuda T, Mar L, Foncin JF, Bruni AC, Montesi MP, ... ... Roses AD, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 375: 754-60. PMID 7596406 DOI: 10.1038/375754A0  0.316
1995 Roses AD, Saunders A. Head injury, amyloid beta and Alzheimer's disease. Nature Medicine. 1: 603-4. PMID 7585131 DOI: 10.1038/Nm0795-603  0.328
1995 Huang DY, Weisgraber KH, Goedert M, Saunders AM, Roses AD, Strittmatter WJ. ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. Neuroscience Letters. 192: 209-12. PMID 7566652 DOI: 10.1016/0304-3940(95)11649-H  0.68
1995 Masliah E, Mallory M, Ge N, Alford M, Veinbergs I, Roses AD. Neurodegeneration in the central nervous system of apoE-deficient mice. Experimental Neurology. 136: 107-22. PMID 7498401 DOI: 10.1006/Exnr.1995.1088  0.301
1995 Strittmatter WJ, Roses AD. Apolipoprotein E: Emerging Story in the Pathogenesis of Alzheimer's Disease The Neuroscientist. 1: 298-306. DOI: 10.1177/107385849500100507  0.671
1995 Roses A, Saunders A, Pericak-Vance M, Schmechel D, Strittmatter W. Apoliporotein E is a susceptibility locus for Alzheimer disease Pharmacological Research. 31: 16. DOI: 10.1016/1043-6618(95)86323-0  0.614
1994 Roses AD, Pericak-Vance MA, Saunders AM, Schmechel D, Goldgaber D, Strittmatter W. Complex genetic disease: can genetic strategies in Alzheimer's disease and new genetic mechanisms be applied to epilepsy? Epilepsia. 35: S20-8. PMID 8293721 DOI: 10.1111/J.1528-1157.1994.Tb05925.X  0.642
1994 Peacock ML, Murman DL, Sima AA, Warren JT, Roses AD, Fink JK. Novel amyloid precursor protein gene mutation (codon 665Asp) in a patient with late-onset Alzheimer's disease. Annals of Neurology. 35: 432-8. PMID 8154870 DOI: 10.1002/Ana.410350410  0.42
1994 Han SH, Einstein G, Weisgraber KH, Strittmatter WJ, Saunders AM, Pericak-Vance M, Roses AD, Schmechel DE. Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study. Journal of Neuropathology and Experimental Neurology. 53: 535-44. PMID 8083695 DOI: 10.1097/00005072-199409000-00013  0.602
1994 Roses AD. Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease. Journal of Neuropathology and Experimental Neurology. 53: 429-37. PMID 8083686 DOI: 10.1097/00005072-199409000-00002  0.408
1994 Han SH, Hulette C, Saunders AM, Einstein G, Pericak-Vance M, Strittmatter WJ, Roses AD, Schmechel DE. Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. Experimental Neurology. 128: 13-26. PMID 8070517 DOI: 10.1006/Exnr.1994.1108  0.644
1994 Weisgraber KH, Roses AD, Strittmatter WJ. The role of apolipoprotein E in the nervous system. Current Opinion in Lipidology. 5: 110-6. PMID 8044413 DOI: 10.1097/00041433-199404000-00007  0.624
1994 Sanan DA, Weisgraber KH, Russell SJ, Mahley RW, Huang D, Saunders A, Schmechel D, Wisniewski T, Frangione B, Roses AD. Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3. The Journal of Clinical Investigation. 94: 860-9. PMID 8040342 DOI: 10.1172/Jci117407  0.495
1994 Strittmatter WJ, Saunders AM, Goedert M, Weisgraber KH, Dong LM, Jakes R, Huang DY, Pericak-Vance M, Schmechel D, Roses AD. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 91: 11183-6. PMID 7972031 DOI: 10.1073/Pnas.91.23.11183  0.693
1994 Goedert M, Strittmatter WJ, Roses AD. Alzheimer's disease. Risky apolipoprotein in brain. Nature. 372: 45-6. PMID 7969418 DOI: 10.1038/372045A0  0.575
1994 Burke JR, Wingfield MS, Lewis KE, Roses AD, Lee JE, Hulette C, Pericak-Vance MA, Vance JM. The Haw River syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family. Nature Genetics. 7: 521-4. PMID 7951323 DOI: 10.1038/Ng0894-521  0.352
1994 Graffagnino C, Herbstreith MH, Roses AD, Alberts MJ. A molecular genetic study of intracerebral hemorrhage. Archives of Neurology. 51: 981-4. PMID 7945009 DOI: 10.1001/Archneur.1994.00540220027011  0.305
1994 Roses AD, Strittmatter WJ, Pericak-Vance MA, Corder EH, Saunders AM, Schmechel DE. Clinical application of apolipoprotein E genotyping to Alzheimer's disease. Lancet. 343: 1564-5. PMID 7911881 DOI: 10.1016/S0140-6736(94)92960-2  0.603
1994 Huang DY, Goedert M, Jakes R, Weisgraber KH, Garner CC, Saunders AM, Pericak-Vance MA, Schmechel DE, Roses AD, Strittmatter WJ. Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease. Neuroscience Letters. 182: 55-8. PMID 7891887 DOI: 10.1016/0304-3940(94)90204-6  0.701
1994 Roses AD. Hereditary components in the neurodegerative diseases: Alzheimer's disease and myotonic dystrophy. Neurobiology of Aging. 15: 243-5. PMID 7838301 DOI: 10.1016/0197-4580(94)90122-8  0.402
1994 Roses AD, Saunders AM. APOE is a major susceptibility gene for Alzheimer's disease. Current Opinion in Biotechnology. 5: 663-7. PMID 7765750 DOI: 10.1016/0958-1669(94)90091-4  0.402
1994 Jensen TG, Roses AD, Jørgensen AL. Apolipoprotein E uptake and degradation via chloroquine-sensitive pathway in cultivated monkey cells overexpressing low density lipoprotein receptor. Neuroscience Letters. 180: 193-6. PMID 7700578 DOI: 10.1016/0304-3940(94)90519-3  0.331
1994 Roses AD. Apolipoprotein E is a relevant susceptibility gene that affects the rate of expression of Alzheimer's disease. Neurobiology of Aging. 15: S165-7. PMID 7700444 DOI: 10.1016/0197-4580(94)90197-X  0.392
1994 Roses AD, Saunders AM, Alberts MJ, Strittmatter WJ, Schmechel DE. Apolipoprotein E  4 Neurology. 44: 2421-2421. DOI: 10.1212/Wnl.44.12.2421  0.517
1994 Roses A, Saunders A, Corder E, Risch N, Haines J, Pericak-Vance M, Han S, Einstein G, Hulette C, Schmechel D, Goedert M, Jakes R, Dong L, Weisgraber K, Holsti M, et al. Apolipoprotein E-e4 and apolipoprotein E-e2 are susceptibility genes that affect the rate of disease expressivity of late-onset familial and sporadic Alzheimer disease Journal of the Neurological Sciences. 127: 2. DOI: 10.1016/0022-510X(94)90109-0  0.66
1993 Strittmatter WJ, Saunders AM, Schmechel D, Pericak-Vance M, Enghild J, Salvesen GS, Roses AD. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 1977-81. PMID 8446617 DOI: 10.1073/Pnas.90.5.1977  0.664
1993 Schmechel DE, Saunders AM, Strittmatter WJ, Crain BJ, Hulette CM, Joo SH, Pericak-Vance MA, Goldgaber D, Roses AD. Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 9649-53. PMID 8415756 DOI: 10.1073/Pnas.90.20.9649  0.589
1993 Ben Othmane K, Middleton LT, Loprest LJ, Wilkinson KM, Lennon F, Rozear MP, Stajich JM, Gaskell PC, Roses AD, Pericak-Vance MA. Localization of a gene (CMT2A) for autosomal dominant Charcot-Marie-Tooth disease type 2 to chromosome 1p and evidence of genetic heterogeneity. Genomics. 17: 370-5. PMID 8406488 DOI: 10.1006/Geno.1993.1334  0.34
1993 Strittmatter WJ, Huang DY, Bhasin R, Roses AD, Goldgaber D. Avid binding of beta A amyloid peptide to its own precursor. Experimental Neurology. 122: 327-34. PMID 8405269 DOI: 10.1006/Exnr.1993.1132  0.649
1993 Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 8098-102. PMID 8367470 DOI: 10.1073/Pnas.90.17.8098  0.659
1993 Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, Getzoff ED, Hu P, Herzfeldt B, Roos RP, Warner C, Deng G, Soriano E, Smyth C, Parge HE, ... ... Roses AD, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase Science. 261: 1047-1051. PMID 8351519 DOI: 10.1126/Science.8351519  0.509
1993 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science (New York, N.Y.). 261: 921-3. PMID 8346443 DOI: 10.1126/Science.8346443  0.609
1993 Liepnieks JJ, Ghetti B, Farlow M, Roses AD, Benson MD. Characterization of amyloid fibril beta-peptide in familial Alzheimer's disease with APP717 mutations. Biochemical and Biophysical Research Communications. 197: 386-92. PMID 8267572 DOI: 10.1006/Bbrc.1993.2491  0.301
1993 Goldgaber D, Schwarzman AI, Bhasin R, Gregori L, Schmechel D, Saunders AM, Roses AD, Strittmatter WJ. Sequestration of amyloid beta-peptide. Annals of the New York Academy of Sciences. 695: 139-43. PMID 8239272 DOI: 10.1111/J.1749-6632.1993.Tb23042.X  0.541
1993 Huang D, Martin M, Hu D, Roses AD, Goldgaber D, Strittmatter WJ. Binding of IgG to amyloid beta A4 peptide via the heavy-chain hinge region with preservation of antigen binding. Journal of Neuroimmunology. 48: 199-203. PMID 8227317 DOI: 10.1016/0165-5728(93)90192-2  0.635
1992 Alberts MJ, Ioannou P, Deucher R, Gilbert J, Lee J, Middleton L, Roses AD. Isolation of a cytochrome oxidase gene overexpressed in Alzheimer's disease brain. Molecular and Cellular Neurosciences. 3: 461-70. PMID 19912889 DOI: 10.1016/1044-7431(92)90057-9  0.359
1992 Small KW, Weber JL, Hung WY, Vance J, Roses A, Pericak-Vance M. North Carolina macular dystrophy: exclusion map using RFLPs and microsatellites. Genomics. 11: 763-6. PMID 1685483 DOI: 10.1016/0888-7543(91)90087-U  0.325
1992 Small KW, Weber JL, Roses A, Lennon F, Vance JM, Pericak-Vance MA. North Carolina macular dystrophy is assigned to chromosome 6. Genomics. 13: 681-5. PMID 1639395 DOI: 10.1016/0888-7543(92)90141-E  0.327
1992 Roses A, Alberts M, Strittmatter W. Alzheimer's disease - reassessing the data Current Biology. 2: 7-9. DOI: 10.1016/0960-9822(92)90400-5  0.626
1991 Alberts MJ, Kandt RS, Pericak-Vance MA, Bebout J, Speer MC, Siddique TS, Yamaoka L, Hung WY, Gaskell PC, Roses AD. MspI RFLP for microtubule associated protein-2 (MAP2). Nucleic Acids Research. 19: 960. PMID 1708129 DOI: 10.1093/Nar/19.4.960  0.44
1991 Alberts MJ, Pericak-Vance MA, Royal V, Bebout J, Gaskell P, Thomas J, Hung WY, Clark C, Earl N, Roses AD. Genetic linkage analysis of nerve growth factor (beta) in familial Alzheimer's disease. Annals of Neurology. 30: 216-9. PMID 1680304 DOI: 10.1002/Ana.410300217  0.333
1991 Vance JM, Barker D, Yamaoka LH, Stajich JM, Loprest L, Hung WY, Fischbeck K, Roses AD, Pericak-Vance MA. Localization of Charcot-Marie-Tooth disease type 1a (CMT1A) to chromosome 17p11.2. Genomics. 9: 623-8. PMID 1674726 DOI: 10.1016/0888-7543(91)90355-I  0.306
1989 Roses AD. A conservative viewpoint on linkage in Alzheimer's disease. Neurobiology of Aging. 10: 427-9; discussion 44. PMID 2812200 DOI: 10.1016/0197-4580(89)90083-3  0.394
1989 Laing NG, Siddique T, Bartlett R, Yamaoka LH, Hung WY, Pericak-Vance MA, Roses AD. Duchenne muscular dystrophy: detection of deletion carriers by spectrophotometric densitometry. Clinical Genetics. 35: 393-8. PMID 2736788 DOI: 10.1111/J.1399-0004.1989.Tb02963.X  0.531
1989 Siddique T, Roper H, Pericak-Vance MA, Shaw J, Warner KL, Hung WY, Phillips KL, Lunt P, Cumming WJ, Roses AD. Linkage analysis in the spinal muscular atrophy type of facioscapulohumeral disease. Journal of Medical Genetics. 26: 487-9. PMID 2570155 DOI: 10.1136/Jmg.26.8.487  0.5
1989 Siddique T, Phillips K, Betz H, Grenningloh G, Warner K, Hung WY, Laing N, Roses AD. RFLPs of the gene for the human glycine receptor on the X-chromosome. Nucleic Acids Research. 17: 1785. PMID 2564191 DOI: 10.1093/Nar/17.4.1785  0.435
1988 Gilchrist JM, Pericak-Vance M, Silverman L, Roses AD. Clinical and genetic investigation in autosomal dominant limb-girdle muscular dystrophy. Neurology. 38: 5-9. PMID 3275904 DOI: 10.1212/Wnl.38.1.5  0.317
1988 Bartlett RJ, Pericak-Vance MA, Koh J, Yamaoka LH, Chen JC, Hung WY, Speer MC, Wapenaar MC, Van Ommen GJB, Bakker E, Pearson PL, Kandt RS, Siddique T, Gilbert JR, Lee JE, ... ... Roses AD, et al. Duchenne muscular dystrophy: High frequency of deletions Neurology. 38: 1-4. PMID 3275902 DOI: 10.1212/Wnl.38.1.1  0.478
1988 Siddique T, Bartlett R, Pericak-Vance M, Yamaoka L, Koh J, Chen J, Hung WY, Kandt R, Roses AD. Update on the molecular genetics of Duchenne muscular dystrophy. Australian Paediatric Journal. 24: 9-14. PMID 3060079  0.478
1988 Walker AP, Bartlett RJ, Laing NG, Siddique T, Yamaoka LH, Chen JC, Hung WY, Roses AD. RFLP for Duchenne muscular dystrophy cDNA clone 30-2. Nucleic Acids Research. 16: 9072. PMID 2902573 DOI: 10.1093/Nar/16.18.9072  0.434
1988 Laing NG, Siddique T, Bartlett RJ, Yamaoka LH, Chen JC, Walker AP, Hung WY, Roses AD. RFLP for Duchenne muscular dystrophy cDNA clone 44-1. Nucleic Acids Research. 16: 7209. PMID 2900496 DOI: 10.1093/Nar/16.14.7209  0.434
1988 Siddique T, McKinney R, Hung WY, Bartlett RJ, Bruns G, Mohandas TK, Ropers HH, Wilfert C, Roses AD. The poliovirus sensitivity (PVS) gene is on chromosome 19q12----q13.2. Genomics. 3: 156-60. PMID 2852161 DOI: 10.1016/0888-7543(88)90147-4  0.519
1987 Vance JM, Pericak-Vance MA, Bowman MH, Payne CS, Fredane L, Siddique T, Roses AD, Massey EW. Chorea-acanthocytosis: a report of three new families and implications for genetic counselling. American Journal of Medical Genetics. 28: 403-10. PMID 3322006 DOI: 10.1002/Ajmg.1320280219  0.459
1986 Roses AD, Pericak-Vance MA, Yamaoka LH, Herbstreith MH, Bartlett RJ, Siddique T, Hung WY, Ross DA, Mohandas TK, Bruns G. A new tightly linked DNA probe for myotonic dystrophy. Neurology. 36: 1146. PMID 3736889 DOI: 10.1212/Wnl.36.8.1146  0.478
1986 Roses AD. Alzheimer's disease: New genetic research strategies Neurobiology of Aging. 7: 466-468. DOI: 10.1016/0197-4580(86)90072-2  0.383
1983 Roses AD, Pericak-Vance MA, Yamaoka LH, Stubblefield E, Stajich J, Vance JM, Roses MJ, Carter DB. Recombinant DNA strategies in genetic neurological diseases. Muscle & Nerve. 6: 339-55. PMID 6310392 DOI: 10.1002/Mus.880060503  0.354
1976 Roses AD, Roses MJ, Miller SE, Hull KL, Appel SH. Carrier detection in Duchenne muscular dystrophy. The New England Journal of Medicine. 294: 193-8. PMID 1244534 DOI: 10.1056/Nejm197601222940404  0.468
1976 Roses AD, Appel SH. Erythrocyte spectrin peak II phosphorylation in Duchenne muscular dystrophy. Journal of the Neurological Sciences. 29: 185-93. PMID 978207 DOI: 10.1016/0022-510X(76)90170-2  0.474
1976 Butterfield DA, Roses AD, Appel SH, Chesnut DB. Electron spin resonance studies of membrane proteins in erythrocytes in myotonic muscular dystrophy. Archives of Biochemistry and Biophysics. 177: 226-34. PMID 187121 DOI: 10.1016/0003-9861(76)90432-X  0.451
1976 Butterfield DA, Chesnut DB, Appel SH, Roses AD. Spin label study of erythrocyte membrane fluidity in myotonic and Duchenne muscular dystrophy and congenital myotonia. Nature. 263: 159-61. PMID 184394 DOI: 10.1038/263159A0  0.383
1976 Roses AD, Herbstreith M, Metcalf B, Appel SH. Increased phosphorylated components of erythrocyte membrane spectrin band II with reference to Duchenne muscular dystrophy. Journal of the Neurological Sciences. 30: 167-78. PMID 10352 DOI: 10.1016/0022-510X(76)90264-1  0.438
1976 Miller SE, Roses AD, Appel SH. Scanning electron microscopy studies in muscular dystrophy. Archives of Neurology. 33: 172-4. PMID 3154 DOI: 10.1001/Archneur.1976.00500030028005  0.45
1975 Miller SE, Roses AD, Appel SH. Letter: Erythrocytes in human muscular dystrophy. Science (New York, N.Y.). 188: 1131. PMID 1215993 DOI: 10.1126/Science.1215993  0.436
1975 Roses AD, Herbstreith MH, Appel SH. Membrane protein kinase alteration in Duchenne muscular dystrophy. Nature. 254: 350-1. PMID 1118019 DOI: 10.1038/254350A0  0.478
1975 Roses AD, Appel SH, Butterfield DA, Miller SE, Chesnut DB. Specificity of biochemical and biophysical tests in Duchenne and myotonic muscular dystrophy, carrier states, and congenital myotonia. Transactions of the American Neurological Association. 100: 131-4. PMID 179179  0.371
1975 Roses AD, Butterfield A, Appel SH, Chestnut DB. Phenytoin and membrane fluidity in myotonic dystrophy. Archives of Neurology. 32: 535-8. PMID 168843 DOI: 10.1001/Archneur.1975.00490500055006  0.446
1975 Roses AD, Appel SH. Phosphorylation of component a of the human erythrocyte membrane in myotonic muscular dystrophy. The Journal of Membrane Biology. 20: 51-8. PMID 123592 DOI: 10.1007/Bf01870627  0.475
1974 Butterfield DA, Roses AD, Cooper ML, Appel SH, Chesnut DB. A comparative electron spin resonance study of the erythrocyte membrane in myotonic muscular dystrophy. Biochemistry. 13: 5078-82. PMID 4373028  0.361
1974 Butterfield DA, Chesnut DB, Roses AD, Appel SH. Electron spin resonance studies of erythrocytes from patients with myotonic muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 71: 909-13. PMID 4362637 DOI: 10.1073/Pnas.71.3.909  0.464
1974 Roses AD, Appel SH. Muscle membrane protein kinase in myotonic muscular dystrophy. Nature. 250: 245-7. PMID 4277586 DOI: 10.1038/250245A0  0.475
1974 Roses AD, Appel SH. Letter: Muscular dystrophies. Lancet (London, England). 2: 1400. PMID 4143368  0.36
1973 Andrew CG, Roses AD, Almon RR, Appel SH. Phosphorylation of muscle membranes: identification of a membrane-bound protein kinase. Science (New York, N.Y.). 182: 927-9. PMID 4355523 DOI: 10.1126/Science.182.4115.927  0.456
1973 Roses AD, Appel SH. Protein kinase activity in erythrocyte ghosts of patients with myotonic muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 70: 1855-9. PMID 4352659 DOI: 10.1073/Pnas.70.6.1855  0.478
1973 Roses AD, Appel SH. Erythrocyte protein phosphorylation. The Journal of Biological Chemistry. 248: 1408-11. PMID 4346955  0.378
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