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Bruce R. Conklin - Publications

Medical Genetics Gladstone Institute of Cardiovascular Disease (UCSF), San Francisco, CA, United States 
G protein-coupled receptors

102 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Fenix AM, Miyaoka Y, Bertero A, Blue SM, Spindler MJ, Tan KKB, Perez-Bermejo JA, Chan AH, Mayerl SJ, Nguyen TD, Russell CR, Lizarraga PP, Truong A, So PL, Kulkarni A, ... ... Conklin BR, et al. Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies. Nature Communications. 12: 6324. PMID 34732726 DOI: 10.1038/s41467-021-26623-y  0.761
2019 Song M, Yang X, Ren X, Maliskova L, Li B, Jones IR, Wang C, Jacob F, Wu K, Traglia M, Tam TW, Jamieson K, Lu SY, Ming GL, Li Y, ... ... Conklin BR, et al. Mapping cis-regulatory chromatin contacts in neural cells links neuropsychiatric disorder risk variants to target genes. Nature Genetics. 51: 1252-1262. PMID 31367015 DOI: 10.1038/S41588-019-0472-1  0.322
2019 Perez-Bermejo JA, Judge LM, Wu K, Jensen CL, Kaake RM, Swaney D, So P, Krogan NJ, Conklin BR. Abstract 934: Physical and Genetic Interaction Analyses in Human Pluripotent Stem Cell-Derived Cardiomyocytes to Study Protein Quality Control Disease in the Heart Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.934  0.326
2018 Ma Z, Huebsch N, Koo S, Mandegar MA, Siemons B, Boggess S, Conklin BR, Grigoropoulos CP, Healy KE. Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload. Nature Biomedical Engineering. 2: 955-967. PMID 31015724 DOI: 10.1038/S41551-018-0280-4  0.316
2018 Eskildsen TV, Ayoubi S, Thomassen M, Burton M, Mandegar MA, Conklin BR, Jensen CH, Andersen DC, Sheikh SP. MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification. Developmental Biology. PMID 30389344 DOI: 10.1016/J.Ydbio.2018.10.020  0.351
2018 Libby AR, Joy DA, So PL, Mandegar MA, Muncie JM, Mendoza-Camacho FN, Weaver VM, Conklin BR, McDevitt TC. Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference. Elife. 7. PMID 30298816 DOI: 10.7554/Elife.36045  0.35
2018 Hoang P, Wang J, Conklin BR, Healy KE, Ma Z. Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells. Nature Protocols. 13: 723-737. PMID 29543795 DOI: 10.1038/Nprot.2018.006  0.348
2017 Judge LM, Perez-Bermejo JA, Truong A, Ribeiro AJ, Yoo JC, Jensen CL, Mandegar MA, Huebsch N, Kaake RM, So PL, Srivastava D, Pruitt BL, Krogan NJ, Conklin BR. A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress. Jci Insight. 2. PMID 28724793 DOI: 10.1172/Jci.Insight.94623  0.363
2017 Ribeiro AJ, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes. Circulation Research. PMID 28400398 DOI: 10.1161/Circresaha.116.310363  0.35
2017 Huang M, Zheng T, Guo J, Sperring C, Miller M, McHenry L, Zhen Q, Moriarity B, Bronner M, Conklin B, Largaespada D, Maris J, Matthay K, Weiss W. TMOD-09. HUMAN PLURIPOTENT STEM CELL-BASED MODELS OF NEUROBLASTOMA Neuro-Oncology. 19: vi256-vi256. DOI: 10.1093/Neuonc/Nox168.1048  0.32
2016 Liu SJ, Horlbeck MA, Cho SW, Birk HS, Malatesta M, He D, Attenello FJ, Villalta JE, Cho MY, Chen Y, Mandegar MA, Olvera MP, Gilbert LA, Conklin BR, Chang HY, et al. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science (New York, N.Y.). PMID 27980086 DOI: 10.1126/Science.Aah7111  0.352
2016 Workman MJ, Mahe MM, Trisno S, Poling HM, Watson CL, Sundaram N, Chang CF, Schiesser J, Aubert P, Stanley EG, Elefanty AG, Miyaoka Y, Mandegar MA, Conklin BR, Neunlist M, et al. Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Nature Medicine. PMID 27869805 DOI: 10.1038/Nm.4233  0.323
2016 Hayashi Y, Hsiao EC, Sami S, Lancero M, Schlieve CR, Nguyen T, Yano K, Nagahashi A, Ikeya M, Matsumoto Y, Nishimura K, Fukuda A, Hisatake K, Tomoda K, Asaka I, ... ... Conklin BR, et al. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence. Proceedings of the National Academy of Sciences of the United States of America. PMID 27794120 DOI: 10.1073/Pnas.1603668113  0.367
2016 Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nature Communications. 7: 12009. PMID 27363581 DOI: 10.1038/Ncomms12009  0.318
2016 Mandegar MA, Huebsch N, Frolov EB, Shin E, Truong A, Olvera MP, Chan AH, Miyaoka Y, Holmes K, Spencer CI, Judge LM, Gordon DE, Eskildsen TV, Villalta JE, Horlbeck MA, ... ... Conklin BR, et al. CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs. Cell Stem Cell. PMID 26971820 DOI: 10.1016/J.Stem.2016.01.022  0.39
2016 Huang M, Miller ML, McHenry LK, Zheng T, Zhen Q, Ilkhanizadeh S, Conklin BR, Bronner ME, Weiss WA. Generating trunk neural crest from human pluripotent stem cells. Scientific Reports. 6: 19727. PMID 26812940 DOI: 10.1038/Srep19727  0.331
2016 Kime C, Mandegar MA, Srivastava D, Yamanaka S, Conklin BR, Rand TA. Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells. Current Protocols in Human Genetics / Editorial Board, Jonathan L. Haines ... [Et Al.]. 88: 21.4.1-21.4.23. PMID 26724721 DOI: 10.1002/0471142905.Hg2104S88  0.336
2015 Ma Z, Wang J, Loskill P, Huebsch N, Koo S, Svedlund FL, Marks NC, Hua EW, Grigoropoulos CP, Conklin BR, Healy KE. Self-organizing human cardiac microchambers mediated by geometric confinement. Nature Communications. 6: 7413. PMID 26172574 DOI: 10.1038/Ncomms8413  0.335
2015 Wang L, Hsiao EC, Lieu S, Scott M, O'Carroll D, Urrutia A, Conklin BR, Colnot C, Nissenson RA. Loss of Gi G-Protein-Coupled Receptor Signaling in Osteoblasts Accelerates Bone Fracture Healing. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 25917236 DOI: 10.1002/Jbmr.2540  0.324
2015 Hayashi Y, Caboni L, Das D, Yumoto F, Clayton T, Deller MC, Nguyen P, Farr CL, Chiu HJ, Miller MD, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Tomoda K, ... Conklin BR, et al. Structure-based discovery of NANOG variant with enhanced properties to promote self-renewal and reprogramming of pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4666-71. PMID 25825768 DOI: 10.1073/Pnas.1502855112  0.347
2015 Maddah M, Heidmann JD, Mandegar MA, Walker CD, Bolouki S, Conklin BR, Loewke KE. A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing. Stem Cell Reports. 4: 621-31. PMID 25801505 DOI: 10.1016/J.Stemcr.2015.02.007  0.301
2015 Mathur A, Loskill P, Shao K, Huebsch N, Hong S, Marcus SG, Marks N, Mandegar M, Conklin BR, Lee LP, Healy KE. Human iPSC-based cardiac microphysiological system for drug screening applications. Scientific Reports. 5: 8883. PMID 25748532 DOI: 10.1038/Srep08883  0.326
2015 Wattanachanya L, Wang L, Millard SM, Lu WD, O'Carroll D, Hsiao EC, Conklin BR, Nissenson RA. Assessing the osteoblast transcriptome in a model of enhanced bone formation due to constitutive Gs-G protein signaling in osteoblasts. Experimental Cell Research. 333: 289-302. PMID 25704759 DOI: 10.1016/J.Yexcr.2015.02.009  0.357
2015 Huebsch N, Loskill P, Mandegar MA, Marks NC, Sheehan AS, Ma Z, Mathur A, Nguyen TN, Yoo JC, Judge LM, Spencer CI, Chukka AC, Russell CR, So PL, Conklin BR, et al. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales. Tissue Engineering. Part C, Methods. 21: 467-79. PMID 25333967 DOI: 10.1089/Ten.Tec.2014.0283  0.32
2015 Huang M, McHenry LK, Miller ML, Kim GE, Moriarity BS, Miyaoka Y, Bronner ME, Largaespada DA, Conklin BR, Ji HP, Maris JM, Matthay KK, Weiss WA. Abstract 3230: Human stem cell-based model of MYCN-driven neuroblastoma Cancer Research. 75: 3230-3230. DOI: 10.1158/1538-7445.Am2015-3230  0.351
2014 Spencer CI, Baba S, Nakamura K, Hua EA, Sears MA, Fu CC, Zhang J, Balijepalli S, Tomoda K, Hayashi Y, Lizarraga P, Wojciak J, Scheinman MM, Aalto-Setälä K, Makielski JC, ... ... Conklin BR, et al. Calcium transients closely reflect prolonged action potentials in iPSC models of inherited cardiac arrhythmia. Stem Cell Reports. 3: 269-81. PMID 25254341 DOI: 10.1016/J.Stemcr.2014.06.003  0.317
2014 Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proceedings of the National Academy of Sciences of the United States of America. 111: 5896-901. PMID 24711398 DOI: 10.1073/Pnas.1402087111  0.638
2014 Miyaoka Y, Chan AH, Judge LM, Yoo J, Huang M, Nguyen TD, Lizarraga PP, So PL, Conklin BR. Isolation of single-base genome-edited human iPS cells without antibiotic selection. Nature Methods. 11: 291-3. PMID 24509632 DOI: 10.1038/Nmeth.2840  0.32
2014 Ma Z, Koo S, Finnegan MA, Loskill P, Huebsch N, Marks NC, Conklin BR, Grigoropoulos CP, Healy KE. Three-dimensional filamentous human diseased cardiac tissue model. Biomaterials. 35: 1367-77. PMID 24268663 DOI: 10.1016/J.Biomaterials.2013.10.052  0.321
2014 Taglieri DM, Johnson KR, Burmeister BT, Monasky MM, Spindler MJ, DeSantiago J, Banach K, Conklin BR, Carnegie GK. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 66: 27-40. PMID 24161911 DOI: 10.1016/J.Yjmcc.2013.10.010  0.763
2013 Mathur A, Loskill P, Hong S, Lee J, Marcus SG, Dumont L, Conklin BR, Willenbring H, Lee LP, Healy KE. Human induced pluripotent stem cell-based microphysiological tissue models of myocardium and liver for drug development. Stem Cell Research & Therapy. 4: S14. PMID 24565415 DOI: 10.1186/Scrt375  0.314
2013 Matsumoto Y, Hayashi Y, Schlieve CR, Ikeya M, Kim H, Nguyen TD, Sami S, Baba S, Barruet E, Nasu A, Asaka I, Otsuka T, Yamanaka S, Conklin BR, Toguchida J, et al. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation. Orphanet Journal of Rare Diseases. 8: 190. PMID 24321451 DOI: 10.1186/1750-1172-8-190  0.343
2013 Kreitzer FR, Salomonis N, Sheehan A, Huang M, Park JS, Spindler MJ, Lizarraga P, Weiss WA, So PL, Conklin BR. A robust method to derive functional neural crest cells from human pluripotent stem cells. American Journal of Stem Cells. 2: 119-31. PMID 23862100  0.774
2013 Spindler MJ, Burmeister BT, Huang Y, Hsiao EC, Salomonis N, Scott MJ, Srivastava D, Carnegie GK, Conklin BR. AKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophy. Plos One. 8: e62705. PMID 23658642 DOI: 10.1371/Journal.Pone.0062705  0.763
2012 Zambon AC, Gaj S, Ho I, Hanspers K, Vranizan K, Evelo CT, Conklin BR, Pico AR, Salomonis N. GO-Elite: a flexible solution for pathway and ontology over-representation. Bioinformatics (Oxford, England). 28: 2209-10. PMID 22743224 DOI: 10.1093/Bioinformatics/Bts366  0.71
2012 Kelder T, van Iersel MP, Hanspers K, Kutmon M, Conklin BR, Evelo CT, Pico AR. WikiPathways: building research communities on biological pathways. Nucleic Acids Research. 40: D1301-7. PMID 22096230 DOI: 10.1093/Nar/Gkr1074  0.617
2011 Hsiao EC, Nguyen TD, Ng JK, Scott MJ, Chang WC, Zahed H, Conklin BR. Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice. Stem Cell Research & Therapy. 2: 11. PMID 21375737 DOI: 10.1186/Scrt52  0.546
2010 Kelder T, Conklin BR, Evelo CT, Pico AR. Finding the right questions: exploratory pathway analysis to enhance biological discovery in large datasets. Plos Biology. 8. PMID 20824171 DOI: 10.1371/Journal.Pbio.1000472  0.609
2010 Salomonis N, Conklin BR. Stem cell pluripotency: alternative modes of transcription regulation. Cell Cycle (Georgetown, Tex.). 9: 3133-4. PMID 20814242 DOI: 10.4161/Cc.9.16.12888  0.636
2010 van Laake LW, Qian L, Cheng P, Huang Y, Hsiao EC, Conklin BR, Srivastava D. Reporter-based isolation of induced pluripotent stem cell- and embryonic stem cell-derived cardiac progenitors reveals limited gene expression variance. Circulation Research. 107: 340-7. PMID 20558827 DOI: 10.1161/Circresaha.109.215434  0.371
2010 Emig D, Salomonis N, Baumbach J, Lengauer T, Conklin BR, Albrecht M. AltAnalyze and DomainGraph: analyzing and visualizing exon expression data. Nucleic Acids Research. 38: W755-62. PMID 20513647 DOI: 10.1093/Nar/Gkq405  0.601
2010 Salomonis N, Schlieve CR, Pereira L, Wahlquist C, Colas A, Zambon AC, Vranizan K, Spindler MJ, Pico AR, Cline MS, Clark TA, Williams A, Blume JE, Samal E, Mercola M, ... ... Conklin BR, et al. Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 107: 10514-9. PMID 20498046 DOI: 10.1073/Pnas.0912260107  0.772
2010 Hsiao EC, Boudignon BM, Halloran BP, Nissenson RA, Conklin BR. Gs G protein-coupled receptor signaling in osteoblasts elicits age-dependent effects on bone formation. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 25: 584-93. PMID 20200944 DOI: 10.1002/Jbmr.3  0.306
2010 van Iersel MP, Pico AR, Kelder T, Gao J, Ho I, Hanspers K, Conklin BR, Evelo CT. The BridgeDb framework: standardized access to gene, protein and metabolite identifier mapping services. Bmc Bioinformatics. 11: 5. PMID 20047655 DOI: 10.1186/1471-2105-11-5  0.58
2010 Iersel MPv, Pico AR, Kelder T, Gao J, Ho I, Hanspers K, Conklin BR, Evelo CTA. BridgeDb: standardized access to gene, protein and metabolite identifier mapping services Nature Precedings. DOI: 10.1038/Npre.2010.5023.1  0.594
2009 Nakamura K, Salomonis N, Tomoda K, Yamanaka S, Conklin BR. G(i)-coupled GPCR signaling controls the formation and organization of human pluripotent colonies. Plos One. 4: e7780. PMID 19936228 DOI: 10.1371/Journal.Pone.0007780  0.622
2009 Salomonis N, Nelson B, Vranizan K, Pico AR, Hanspers K, Kuchinsky A, Ta L, Mercola M, Conklin BR. Alternative splicing in the differentiation of human embryonic stem cells into cardiac precursors. Plos Computational Biology. 5: e1000553. PMID 19893621 DOI: 10.1371/Journal.Pcbi.1000553  0.747
2009 Kelder T, Pico AR, Hanspers K, van Iersel MP, Evelo C, Conklin BR. Mining biological pathways using WikiPathways web services. Plos One. 4: e6447. PMID 19649250 DOI: 10.1371/Journal.Pone.0006447  0.588
2009 Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, Jacot JG, Nelson B, Spiering S, Haverslag R, Kim C, Talantova M, Bajpai R, Calzolari D, Terskikh A, McCulloch AD, ... ... Conklin BR, et al. Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes. Plos One. 4: e5046. PMID 19352491 DOI: 10.1371/Journal.Pone.0005046  0.609
2009 Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M. SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic Acids Research. 37: D803-9. PMID 18984625 DOI: 10.1093/Nar/Gkn756  0.6
2008 van Iersel MP, Kelder T, Pico AR, Hanspers K, Coort S, Conklin BR, Evelo C. Presenting and exploring biological pathways with PathVisio. Bmc Bioinformatics. 9: 399. PMID 18817533 DOI: 10.1186/1471-2105-9-399  0.618
2008 Conklin BR, Hsiao EC, Claeysen S, Dumuis A, Srinivasan S, Forsayeth JR, Guettier JM, Chang WC, Pei Y, McCarthy KD, Nissenson RA, Wess J, Bockaert J, Roth BL. Engineering GPCR signaling pathways with RASSLs. Nature Methods. 5: 673-8. PMID 18668035 DOI: 10.1038/Nmeth.1232  0.503
2008 Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin BR, Evelo C. WikiPathways: pathway editing for the people. Plos Biology. 6: e184. PMID 18651794 DOI: 10.1371/Journal.Pbio.0060184  0.602
2008 Ivey KN, Muth A, Arnold J, King FW, Yeh RF, Fish JE, Hsiao EC, Schwartz RJ, Conklin BR, Bernstein HS, Srivastava D. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell. 2: 219-29. PMID 18371447 DOI: 10.1016/J.Stem.2008.01.016  0.336
2008 Hsiao EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proceedings of the National Academy of Sciences of the United States of America. 105: 1209-14. PMID 18212126 DOI: 10.1073/Pnas.0707457105  0.47
2008 Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. The Journal of Biological Chemistry. 283: 4304-13. PMID 18048352 DOI: 10.1074/Jbc.M708673200  0.361
2008 Hanspers K, Pico AR, Salomonis N, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Conklin BR. An Introduction to Pathway Analysis with GenMAPP Nci Nature Pathway Interaction Database. DOI: 10.1038/Pid.2008.1  0.704
2007 Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao EC, Conklin BR. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. Plos One. 2: e1317. PMID 18338032 DOI: 10.1371/Journal.Pone.0001317  0.502
2007 Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, ... ... Conklin BR, et al. Integration of biological networks and gene expression data using Cytoscape. Nature Protocols. 2: 2366-82. PMID 17947979 DOI: 10.1038/Nprot.2007.324  0.612
2007 Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. Plos One. 2: e668. PMID 17668051 DOI: 10.1371/Journal.Pone.0000668  0.35
2007 Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. Plos One. 2: e617. PMID 17637833 DOI: 10.1371/Journal.Pone.0000617  0.331
2007 Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Stuart J, Conklin BR, Pico AR. GenMAPP 2: new features and resources for pathway analysis. Bmc Bioinformatics. 8: 217. PMID 17588266 DOI: 10.1186/1471-2105-8-217  0.724
2007 Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proceedings of the National Academy of Sciences of the United States of America. 104: 10894-9. PMID 17576928 DOI: 10.1073/Pnas.0704044104  0.381
2007 Tingley WG, Pawlikowska L, Zaroff JG, Kim T, Nguyen T, Young SG, Vranizan K, Kwok PY, Whooley MA, Conklin BR. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proceedings of the National Academy of Sciences of the United States of America. 104: 8461-6. PMID 17485678 DOI: 10.1073/Pnas.0610393104  0.378
2007 Sweger EJ, Casper KB, Scearce-Levie K, Conklin BR, McCarthy KD. Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2309-17. PMID 17329428 DOI: 10.1523/Jneurosci.4565-06.2007  0.317
2006 Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, et al. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Research. 34: D642-8. PMID 16381950 DOI: 10.1093/Nar/Gkj097  0.35
2006 Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ. Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. American Journal of Physiology. Heart and Circulatory Physiology. 290: H1103-9. PMID 16243914 DOI: 10.1152/Ajpheart.00732.2005  0.31
2005 Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA. Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 102: 8561-6. PMID 15939874 DOI: 10.1073/Pnas.0503363102  0.621
2005 McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiological Genomics. 22: 118-26. PMID 15797971 DOI: 10.1152/Physiolgenomics.00016.2005  0.356
2005 Scearce-Levie K, Lieberman MD, Elliott HH, Conklin BR. Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. Bmc Biology. 3: 3. PMID 15707483 DOI: 10.1186/1741-7007-3-3  0.317
2005 Salomonis N, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR. Identifying genetic networks underlying myometrial transition to labor. Genome Biology. 6: R12. PMID 15693941 DOI: 10.1186/Gb-2005-6-2-R12  0.625
2004 Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. The Journal of Clinical Investigation. 114: 1158-64. PMID 15489963 DOI: 10.1172/Jci21927  0.311
2004 Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J. A public gene trap resource for mouse functional genomics. Nature Genetics. 36: 543-4. PMID 15167922 DOI: 10.1038/Ng0604-543  0.343
2003 Zambon AC, McDearmon EL, Salomonis N, Vranizan KM, Johansen KL, Adey D, Takahashi JS, Schambelan M, Conklin BR. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biology. 4: R61. PMID 14519196 DOI: 10.1186/Gb-2003-4-10-R61  0.571
2003 Srinivasan S, Vaisse C, Conklin BR. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Annals of the New York Academy of Sciences. 994: 225-32. PMID 12851320 DOI: 10.1111/J.1749-6632.2003.Tb03184.X  0.346
2003 Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biology. 4: R7. PMID 12540299 DOI: 10.1186/Gb-2003-4-1-R7  0.595
2002 Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nature Genetics. 31: 19-20. PMID 11984561 DOI: 10.1038/Ng0502-19  0.585
2002 Scearce-Levie K, Coward P, Redfern CH, Conklin BR. Tools for dissecting signaling pathways in vivo: receptors activated solely by synthetic ligands. Methods in Enzymology. 343: 232-48. PMID 11665570 DOI: 10.1016/S0076-6879(02)43139-4  0.348
2001 Scearce-Levie K, Coward P, Redfern CH, Conklin BR. Engineering receptors activated solely by synthetic ligands (RASSLs). Trends in Pharmacological Sciences. 22: 414-20. PMID 11479004 DOI: 10.1016/S0165-6147(00)01743-0  0.35
2001 Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. Abnormal contraction caused by expression of G(i)-coupled receptor in transgenic model of dilated cardiomyopathy. American Journal of Physiology. Heart and Circulatory Physiology. 280: H1653-9. PMID 11247776 DOI: 10.1152/Ajpheart.2001.280.4.H1653  0.316
2000 Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, ... ... Conklin BR, et al. Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 97: 4826-31. PMID 10781088 DOI: 10.1073/Pnas.97.9.4826  0.618
1999 Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nature Biotechnology. 17: 165-9. PMID 10052353 DOI: 10.1038/6165  0.349
1999 Cotte N, Redfern CH, Mikus P, Salomonis N, Degtyarev MY, Coward PS, Kwa A, Shioi T, Shah N, McKinsey T, Olson E, Izumo S, Warrington J, Baker AJ, Conklin BR. A critical period of vulnerability to hyperactive Gq signaling revealed by inducible and heart-specific expression of Gq∗ in transgenic mice Journal of Cardiac Failure. 5: 12. DOI: 10.1016/S1071-9164(99)91387-8  0.571
1998 Coward P, Wada HG, Falk MS, Chan SD, Meng F, Akil H, Conklin BR. Controlling signaling with a specifically designed Gi-coupled receptor. Proceedings of the National Academy of Sciences of the United States of America. 95: 352-7. PMID 9419379 DOI: 10.1073/Pnas.95.1.352  0.333
1996 Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR. Carboxyl-terminal mutations of Gq alpha and Gs alpha that alter the fidelity of receptor activation. Molecular Pharmacology. 50: 885-90. PMID 8863834  0.454
1995 Liu J, Conklin BR, Blin N, Yun J, Wess J. Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proceedings of the National Academy of Sciences of the United States of America. 92: 11642-6. PMID 8524820 DOI: 10.1073/Pnas.92.25.11642  0.317
1994 Conklin BR, Bourne HR. Homeostatic signals. Marriage of the flytrap and the serpent. Nature. 367: 22. PMID 8107768 DOI: 10.1038/367022A0  0.512
1994 Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. G alpha 13 stimulates Na-H exchange. The Journal of Biological Chemistry. 269: 4721-4. PMID 8106440  0.476
1994 Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. Coupling of the alpha 2A-adrenergic receptor to multiple G-proteins. A simple approach for estimating receptor-G-protein coupling efficiency in a transient expression system. The Journal of Biological Chemistry. 269: 5730-4. PMID 7907086  0.497
1994 Conklin BR, Bourne HR. Marriage of the flytrap and the serpent Nature. 367: 22.  0.454
1993 Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR. Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. The Journal of Biological Chemistry. 268: 13900-5. PMID 8390980  0.482
1993 Conklin BR, Bourne HR. Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell. 73: 631-41. PMID 8388779 DOI: 10.1016/0092-8674(93)90245-L  0.512
1993 Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature. 363: 274-6. PMID 8387644 DOI: 10.1038/363274A0  0.507
1993 Conklin BR, Bourne HR. Mouse coat colour reconsidered. Nature. 364: 110. PMID 8321283 DOI: 10.1038/364110B0  0.512
1992 Wong YH, Conklin BR, Bourne HR. Gz-mediated hormonal inhibition of cyclic AMP accumulation. Science (New York, N.Y.). 255: 339-42. PMID 1347957 DOI: 10.1126/Science.1347957  0.535
1992 Bourne HR, Lustig KD, Wong YH, Conklin BR. Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harbor Symposia On Quantitative Biology. 57: 145-8. PMID 1339653 DOI: 10.1101/Sqb.1992.057.01.018  0.522
1992 Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR. A recombinant calcitonin receptor independently stimulates 3',5'-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Molecular Endocrinology (Baltimore, Md.). 6: 551-6. PMID 1316547 DOI: 10.1210/Mend.6.4.1316547  0.53
1992 Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature. 356: 159-61. PMID 1312225 DOI: 10.1038/356159A0  0.519
1992 Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. Recombinant Gq alpha. Mutational activation and coupling to receptors and phospholipase C. The Journal of Biological Chemistry. 267: 31-4. PMID 1309740  0.455
1989 Felder CC, Ma AL, Conklin BR. Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor. Febs Letters. 245: 75-9. PMID 2466702 DOI: 10.1016/0014-5793(89)80195-4  0.557
1988 Conklin BR, Burch RM, Steranka LR, Axelrod J. Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts. The Journal of Pharmacology and Experimental Therapeutics. 244: 646-9. PMID 2894457  0.382
1988 Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI, Axelrod J. Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 8698-702. PMID 2847172 DOI: 10.1073/Pnas.85.22.8698  0.426
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