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Thomas J. McHugh - Publications

Affiliations: 
RIKEN Brain Science Institute, Wakō-shi, Saitama-ken, Japan 
Area:
Hippocampal Systems
Website:
http://www.brain.riken.go.jp/en/t_mchugh.html
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73 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Adaikkan C, Joseph J, Foustoukos G, Wang J, Polygalov D, Boehringer R, Middleton SJ, Huang AJY, Tsai LH, McHugh TJ. Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations. Nature Communications. 15: 2190. PMID 38467602 DOI: 10.1038/s41467-024-46478-3  0.386
2024 Li H, Tamura R, Hayashi D, Asai H, Koga J, Ando S, Yokota S, Kaneko J, Sakurai K, Sumiyoshi A, Yamamoto T, Hikishima K, Tanaka KZ, McHugh TJ, Hisatsune T. Silencing dentate newborn neurons alters excitatory/inhibitory balance and impairs behavioral inhibition and flexibility. Science Advances. 10: eadk4741. PMID 38198539 DOI: 10.1126/sciadv.adk4741  0.756
2023 He H, Wang Y, McHugh TJ. Behavioral status modulates CA2 influence on hippocampal network dynamics. Hippocampus. PMID 36594707 DOI: 10.1002/hipo.23498  0.393
2022 He H, Guan H, McHugh TJ. The expanded circuitry of hippocampal ripples and replay. Neuroscience Research. PMID 36572253 DOI: 10.1016/j.neures.2022.12.010  0.812
2022 Adaikkan C, Wang J, Abdelaal K, Middleton SJ, Bozzelli PL, Wickersham IR, McHugh TJ, Tsai LH. Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration. Neuron. PMID 35987206 DOI: 10.1016/j.neuron.2022.07.023  0.431
2022 Gros A, Lim AWH, Hohendorf V, White N, Eckert M, McHugh TJ, Wang SH. Behavioral and Cellular Tagging in Young and in Early Cognitive Aging. Frontiers in Aging Neuroscience. 14: 809879. PMID 35283750 DOI: 10.3389/fnagi.2022.809879  0.362
2021 Tomar A, McHugh TJ. The impact of stress on the hippocampal spatial code. Trends in Neurosciences. PMID 34916083 DOI: 10.1016/j.tins.2021.11.005  0.794
2021 Guan H, Middleton SJ, Inoue T, McHugh TJ. Lateralization of CA1 assemblies in the absence of CA3 input. Nature Communications. 12: 6114. PMID 34671042 DOI: 10.1038/s41467-021-26389-3  0.799
2021 He H, Boehringer R, Huang AJY, Overton ETN, Polygalov D, Okanoya K, McHugh TJ. CA2 inhibition reduces the precision of hippocampal assembly reactivation. Neuron. PMID 34555316 DOI: 10.1016/j.neuron.2021.08.034  0.527
2021 Tomar A, Polygalov D, McHugh TJ. Differential Impact of Acute and Chronic Stress on CA1 Spatial Coding and Gamma Oscillations. Frontiers in Behavioral Neuroscience. 15: 710725. PMID 34354574 DOI: 10.3389/fnbeh.2021.710725  0.794
2021 Nakajima K, Ishiwata M, Weitemier AZ, Shoji H, Monai H, Miyamoto H, Yamakawa K, Miyakawa T, McHugh TJ, Kato T. Brain-specific heterozygous loss-of-function of ATP2A2, endoplasmic reticulum Ca2+ pump responsible for Darier's disease, causes behavioral abnormalities and a hyper-dopaminergic state. Human Molecular Genetics. PMID 34104969 DOI: 10.1093/hmg/ddab137  0.768
2021 Yoshihara C, Tokita K, Maruyama T, Kaneko M, Tsuneoka Y, Fukumitsu K, Miyazawa E, Shinozuka K, Huang AJ, Nishimori K, McHugh TJ, Tanaka M, Itohara S, Touhara K, Miyamichi K, et al. Calcitonin receptor signaling in the medial preoptic area enables risk-taking maternal care. Cell Reports. 35: 109204. PMID 34077719 DOI: 10.1016/j.celrep.2021.109204  0.296
2021 Robert V, Therreau L, Chevaleyre V, Lepicard E, Viollet C, Cognet J, Huang AJ, Boehringer R, Polygalov D, McHugh TJ, Piskorowski RA. Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1. Elife. 10. PMID 34003113 DOI: 10.7554/eLife.63352  0.798
2021 Tomar A, Polygalov D, Chattarji S, McHugh TJ. Stress enhances hippocampal neuronal synchrony and alters ripple-spike interaction. Neurobiology of Stress. 14: 100327. PMID 33937446 DOI: 10.1016/j.ynstr.2021.100327  0.802
2020 Chen S, McHugh TJ. Further-reaching optogenetics. Nature Biomedical Engineering. 4: 1028-1029. PMID 33159194 DOI: 10.1038/s41551-020-00648-y  0.229
2020 Chen S, He L, Huang AJY, Boehringer R, Robert V, Wintzer ME, Polygalov D, Weitemier AZ, Tao Y, Gu M, Middleton SJ, Namiki K, Hama H, Therreau L, Chevaleyre V, ... ... McHugh TJ, et al. A hypothalamic novelty signal modulates hippocampal memory. Nature. PMID 32999460 DOI: 10.1038/s41586-020-2771-1  0.814
2020 Goode TD, Tanaka KZ, Sahay A, McHugh TJ. An Integrated Index: Engrams, Place Cells, and Hippocampal Memory. Neuron. PMID 32763146 DOI: 10.1016/J.Neuron.2020.07.011  0.793
2020 Kumar D, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu TS, Vogt KE, Muratani M, Ohnishi T, Singh S, Teixeira CM, Chérasse Y, Naoi T, ... ... McHugh TJ, et al. Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation. Neuron. PMID 32502462 DOI: 10.1016/J.Neuron.2020.05.008  0.782
2020 Ohyama K, Kanda T, Miyazaki T, Tsujino N, Ishii R, Ishikawa Y, Muramoto H, Grenier F, Makino Y, McHugh TJ, Yanagisawa M, Greene RW, Vogt KE. Structure of cortical network activity across natural wake and sleep states in mice. Plos One. 15: e0233561. PMID 32470016 DOI: 10.1371/journal.pone.0233561  0.437
2020 Luchetti A, Bota A, Weitemier A, Mizuta K, Sato M, Islam T, McHugh TJ, Tashiro A, Hayashi Y. Two functionally distinct serotonergic projections into hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32414785 DOI: 10.1523/Jneurosci.2724-19.2020  0.774
2020 McHugh TJ, Tanaka KZ. Technologies advancing neuroscience. Neuroscience Research. 152: 1-2. PMID 32192709 DOI: 10.1016/J.Neures.2020.02.006  0.699
2020 Masuda A, Sano C, Zhang Q, Goto H, McHugh TJ, Fujisawa S, Itohara S. The hippocampus encodes delay and value information during delay-discounting decision making. Elife. 9. PMID 32077851 DOI: 10.7554/Elife.52466  0.509
2020 Oe Y, Wang X, Patriarchi T, Konno A, Ozawa K, Yahagi K, Hirai H, Tian L, McHugh TJ, Hirase H. Distinct temporal integration of noradrenaline signaling by astrocytic second messengers during vigilance. Nature Communications. 11: 471. PMID 31980655 DOI: 10.1038/S41467-020-14378-X  0.488
2020 Masuda A, Sano C, Zhang Q, Goto H, McHugh TJ, Fujisawa S, Itohara S. Author response: The hippocampus encodes delay and value information during delay-discounting decision making Elife. DOI: 10.7554/Elife.52466.Sa2  0.354
2019 Middleton SJ, McHugh TJ. CA2: A Highly Connected Intrahippocampal Relay. Annual Review of Neuroscience. PMID 31874067 DOI: 10.1146/annurev-neuro-080719-100343  0.652
2019 Makino Y, Polygalov D, Bolaños F, Benucci A, McHugh TJ. Physiological Signature of Memory Age in the Prefrontal-Hippocampal Circuit. Cell Reports. 29: 3835-3846.e5. PMID 31851917 DOI: 10.1016/j.celrep.2019.11.075  0.526
2019 Liu X, Zeng X, Chen S, Weitemier A, Han S, Blasiak A, Prasad A, Zheng K, Yi Z, Luo B, Yang IH, Thakor N, Chai C, Lim KL, McHugh T, et al. Visualization of Intra-neuronal Motor Protein Transport through Upconversion Microscopy. Angewandte Chemie (International Ed. in English). PMID 31087740 DOI: 10.1002/Anie.201904208  0.703
2019 Adaikkan C, Middleton SJ, Marco A, Pao PC, Mathys H, Kim DN, Gao F, Young JZ, Suk HJ, Boyden ES, McHugh TJ, Tsai LH. Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection. Neuron. PMID 31076275 DOI: 10.1016/j.neuron.2019.04.011  0.67
2019 Nasrallah K, Therreau L, Robert V, Huang AJY, McHugh TJ, Piskorowski RA, Chevaleyre V. Routing Hippocampal Information Flow through Parvalbumin Interneuron Plasticity in Area CA2. Cell Reports. 27: 86-98.e3. PMID 30943417 DOI: 10.1016/J.Celrep.2019.03.014  0.795
2019 Middleton SJ, McHugh TJ. Memory: Sequences Take Time. Current Biology : Cb. 29: R158-R160. PMID 30836085 DOI: 10.1016/j.cub.2019.01.024  0.573
2019 Sakaguchi M, Koyanagi I, Carrier-Ruiz A, Vergara P, Srinivasan S, Sugaya Y, Kasuya M, Yu T, Vogt K, Muratani M, Ohnishi T, Singh S, Teixeira CM, Chérasse Y, Naoi T, ... ... Mchugh TJ, et al. Function of adult-born neurons in maturation of fear memory engram during sleep Ibro Reports. 6: S23-S24. DOI: 10.1016/J.Ibror.2019.07.062  0.764
2018 Tanaka KZ, McHugh TJ. The Hippocampal Engram as a Memory Index. Journal of Experimental Neuroscience. 12: 1179069518815942. PMID 30546263 DOI: 10.1177/1179069518815942  0.811
2018 Tanaka KZ, He H, Tomar A, Niisato K, Huang AJY, McHugh TJ. The hippocampal engram maps experience but not place. Science (New York, N.Y.). 361: 392-397. PMID 30049878 DOI: 10.1126/Science.Aat5397  0.791
2018 Luo R, Uematsu A, Weitemier A, Aquili L, Koivumaa J, McHugh TJ, Johansen JP. A dopaminergic switch for fear to safety transitions. Nature Communications. 9: 2483. PMID 29950562 DOI: 10.1038/S41467-018-04784-7  0.722
2018 Kamiki E, Boehringer R, Polygalov D, Ohshima T, McHugh TJ. Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability. Frontiers in Cellular Neuroscience. 12: 138. PMID 29867369 DOI: 10.3389/Fncel.2018.00138  0.638
2018 Middleton SJ, Kneller EM, Chen S, Ogiwara I, Montal M, Yamakawa K, McHugh TJ. Altered hippocampal replay is associated with memory impairment in mice heterozygous for the Scn2a gene. Nature Neuroscience. PMID 29867081 DOI: 10.1038/S41593-018-0163-8  0.615
2018 Raveau M, Polygalov D, Boehringer R, Amano K, Yamakawa K, McHugh TJ. Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice. Elife. 7. PMID 29485402 DOI: 10.7554/eLife.31543  0.497
2018 Iwano S, Sugiyama M, Hama H, Watakabe A, Hasegawa N, Kuchimaru T, Tanaka KZ, Takahashi M, Ishida Y, Hata J, Shimozono S, Namiki K, Fukano T, Kiyama M, Okano H, ... ... McHugh TJ, et al. Single-cell bioluminescence imaging of deep tissue in freely moving animals. Science (New York, N.Y.). 359: 935-939. PMID 29472486 DOI: 10.1126/Science.Aaq1067  0.74
2018 Chen S, Weitemier AZ, Zeng X, He L, Wang X, Tao Y, Huang AJY, Hashimotodani Y, Kano M, Iwasaki H, Parajuli LK, Okabe S, Teh DBL, All AH, Tsutsui-Kimura I, ... ... McHugh TJ, et al. Near-infrared deep brain stimulation via upconversion nanoparticle-mediated optogenetics. Science (New York, N.Y.). 359: 679-684. PMID 29439241 DOI: 10.1126/Science.Aaq1144  0.788
2018 Chiang MC, Huang AJY, Wintzer ME, Ohshima T, McHugh TJ. A role for CA3 in social recognition memory. Behavioural Brain Research. PMID 29355673 DOI: 10.1016/J.Bbr.2018.01.019  0.791
2017 Soya S, Takahashi TM, McHugh TJ, Maejima T, Herlitze S, Abe M, Sakimura K, Sakurai T. Orexin modulates behavioral fear expression through the locus coeruleus. Nature Communications. 8: 1606. PMID 29151577 DOI: 10.1038/S41467-017-01782-Z  0.457
2017 Boehringer R, Polygalov D, Huang AJY, Middleton SJ, Robert V, Wintzer ME, Piskorowski RA, Chevaleyre V, McHugh TJ. Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability. Neuron. 94: 642-655.e9. PMID 28472661 DOI: 10.1016/J.Neuron.2017.04.014  0.811
2017 Yasuda K, Hayashi Y, Yoshida T, Kashiwagi M, Nakagawa N, Michikawa T, Tanaka M, Ando R, Huang A, Hosoya T, McHugh TJ, Kuwahara M, Itohara S. Schizophrenia-like phenotypes in mice with NMDA receptor ablation in intralaminar thalamic nucleus cells and gene therapy-based reversal in adults. Translational Psychiatry. 7: e1047. PMID 28244984 DOI: 10.1038/tp.2017.19  0.315
2017 Raveau M, Polygalov D, Boehringer R, Amano K, Yamakawa K, McHugh TJ. Author response: Alterations of in vivo CA1 network activity in Dp(16)1Yey Down syndrome model mice Elife. DOI: 10.7554/Elife.31543.023  0.466
2016 Weitemier AZ, McHugh TJ. Noradrenergic modulation of evoked dopamine release and pH shift in the mouse dorsal hippocampus and ventral striatum. Brain Research. PMID 27919729 DOI: 10.1016/j.brainres.2016.12.002  0.728
2016 Middleton SJ, McHugh TJ. Silencing CA3 disrupts temporal coding in the CA1 ensemble. Nature Neuroscience. PMID 27239937 DOI: 10.1038/nn.4311  0.617
2016 Miyamoto D, Hirai D, Fung CC, Inutsuka A, Odagawa M, Suzuki T, Boehringer R, Adaikkan C, Matsubara C, Matsuki N, Fukai T, McHugh TJ, Yamanaka A, Murayama M. Top-down cortical input during NREM sleep consolidates perceptual memory. Science (New York, N.Y.). PMID 27229145 DOI: 10.1126/Science.Aaf0902  0.341
2016 Yu LM, Polygalov D, Wintzer ME, Chiang MC, McHugh TJ. CA3 Synaptic Silencing Attenuates Kainic Acid-Induced Seizures and Hippocampal Network Oscillations. Eneuro. 3. PMID 27022627 DOI: 10.1523/ENEURO.0003-16.2016  0.777
2015 Sakaguchi M, Kim K, Yu LM, Hashikawa Y, Sekine Y, Okumura Y, Kawano M, Hayashi M, Kumar D, Boyden ES, McHugh TJ, Hayashi Y. Inhibiting the Activity of CA1 Hippocampal Neurons Prevents the Recall of Contextual Fear Memory in Inducible ArchT Transgenic Mice. Plos One. 10: e0130163. PMID 26075894 DOI: 10.1371/Journal.Pone.0130163  0.588
2015 Tomar A, Polygalov D, Chattarji S, McHugh TJ. The dynamic impact of repeated stress on the hippocampal spatial map. Hippocampus. 25: 38-50. PMID 25139366 DOI: 10.1002/hipo.22348  0.796
2014 Chinnakkaruppan A, Wintzer ME, McHugh TJ, Rosenblum K. Differential contribution of hippocampal subfields to components of associative taste learning. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 11007-15. PMID 25122900 DOI: 10.1523/JNEUROSCI.0956-14.2014  0.554
2014 Wintzer ME, Boehringer R, Polygalov D, McHugh TJ. The hippocampal CA2 ensemble is sensitive to contextual change. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 3056-66. PMID 24553945 DOI: 10.1523/JNEUROSCI.2563-13.2014  0.487
2013 Shih PY, Savtchenko LP, Kamasawa N, Dembitskaya Y, McHugh TJ, Rusakov DA, Shigemoto R, Semyanov A. Retrograde synaptic signaling mediated by K+ efflux through postsynaptic NMDA receptors. Cell Reports. 5: 941-51. PMID 24268779 DOI: 10.1016/J.Celrep.2013.10.026  0.368
2013 Aizawa H, Yanagihara S, Kobayashi M, Niisato K, Takekawa T, Harukuni R, McHugh TJ, Fukai T, Isomura Y, Okamoto H. The synchronous activity of lateral habenular neurons is essential for regulating hippocampal theta oscillation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8909-21. PMID 23678132 DOI: 10.1523/Jneurosci.4369-12.2013  0.793
2012 Wu YW, Grebenyuk S, McHugh TJ, Rusakov DA, Semyanov A. Backpropagating action potentials enable detection of extrasynaptic glutamate by NMDA receptors. Cell Reports. 1: 495-505. PMID 22832274 DOI: 10.1016/J.Celrep.2012.03.007  0.397
2012 Place R, Lykken C, Beer Z, Suh J, McHugh TJ, Tonegawa S, Eichenbaum H, Sauvage MM. NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. Learning & Memory (Cold Spring Harbor, N.Y.). 19: 164-9. PMID 22419815 DOI: 10.1101/Lm.025254.111  0.798
2012 Nakashiba T, Cushman JD, Pelkey KA, Renaudineau S, Buhl DL, McHugh TJ, Rodriguez Barrera V, Chittajallu R, Iwamoto KS, McBain CJ, Fanselow MS, Tonegawa S. Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion. Cell. 149: 188-201. PMID 22365813 DOI: 10.1016/J.Cell.2012.01.046  0.774
2011 Jones MW, McHugh TJ. Updating hippocampal representations: CA2 joins the circuit. Trends in Neurosciences. 34: 526-35. PMID 21880379 DOI: 10.1016/J.Tins.2011.07.007  0.626
2011 Yoshimi K, Naya Y, Mitani N, Kato T, Inoue M, Natori S, Takahashi T, Weitemier A, Nishikawa N, McHugh T, Einaga Y, Kitazawa S. Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes. Neuroscience Research. 71: 49-62. PMID 21645558 DOI: 10.1016/J.Neures.2011.05.013  0.706
2011 Kobayashi Y, Lee K, Goto H, McHugh T, Kawasaki H, Itohara S. The role of cAMP-GEF II/RapGEF4/Epac2 in neural function related to memory and impulsive behavior Neuroscience Research. 71: e181. DOI: 10.1016/j.neures.2011.07.781  0.356
2011 Wintzer ME, Boehringer R, McHugh TJ. The role of CA3 and DG synaptic plasticity on the environmental specific expression of the IEGs Arc and Homer1a Neuroscience Research. 71: e179. DOI: 10.1016/j.neures.2011.07.772  0.472
2010 Kamsler A, McHugh TJ, Gerber D, Huang SY, Tonegawa S. Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 107: 1618-23. PMID 20080609 DOI: 10.1073/pnas.0912540107  0.807
2009 McHugh TJ, Tonegawa S. CA3 NMDA receptors are required for the rapid formation of a salient contextual representation. Hippocampus. 19: 1153-8. PMID 19650121 DOI: 10.1002/hipo.20684  0.685
2009 Nakashiba T, Buhl DL, McHugh TJ, Tonegawa S. Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory. Neuron. 62: 781-7. PMID 19555647 DOI: 10.1016/j.neuron.2009.05.013  0.845
2009 McHugh T, Nakashiba T, Buhl DL, Young JZ, Tonegawa S. The role of CA3 transmission in the acquisition and consolidation of spatial memory Neuroscience Research. 65: S31. DOI: 10.1016/j.neures.2009.09.1674  0.832
2008 Nakashiba T, Young JZ, McHugh TJ, Buhl DL, Tonegawa S. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science (New York, N.Y.). 319: 1260-4. PMID 18218862 DOI: 10.1126/science.1151120  0.832
2008 Tonegawa S, McHugh TJ. The ins and outs of hippocampal circuits. Neuron. 57: 175-7. PMID 18215616 DOI: 10.1016/j.neuron.2008.01.005  0.721
2007 McHugh TJ, Jones MW, Quinn JJ, Balthasar N, Coppari R, Elmquist JK, Lowell BB, Fanselow MS, Wilson MA, Tonegawa S. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science (New York, N.Y.). 317: 94-9. PMID 17556551 DOI: 10.1126/Science.1140263  0.749
2007 McHugh TJ, Tonegawa S. Spatial exploration is required for the formation of contextual fear memory. Behavioral Neuroscience. 121: 335-9. PMID 17469922 DOI: 10.1037/0735-7044.121.2.335  0.667
2004 Nakazawa K, McHugh TJ, Wilson MA, Tonegawa S. NMDA receptors, place cells and hippocampal spatial memory. Nature Reviews. Neuroscience. 5: 361-72. PMID 15100719 DOI: 10.1038/nrn1385  0.811
1996 Tonegawa S, Tsien JZ, McHugh TJ, Huerta P, Blum KI, Wilson MA. Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning. Cold Spring Harbor Symposia On Quantitative Biology. 61: 225-38. PMID 9246451 DOI: 10.1101/Sqb.1996.061.01.025  0.807
1996 McHugh TJ, Blum KI, Tsien JZ, Tonegawa S, Wilson MA. Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell. 87: 1339-49. PMID 8980239 DOI: 10.1016/S0092-8674(00)81828-0  0.827
1994 Hastings G, Kleinherenbrink FA, Lin S, McHugh TJ, Blankenship RE. Observation of the reduction and reoxidation of the primary electron acceptor in photosystem I. Biochemistry. 33: 3193-200. PMID 8136354 DOI: 10.1021/Bi00177A008  0.212
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