Stephen L. Helfand - Publications

Molecular Biology, Cell Biology and Biochemistry Brown University, Providence, RI 

84 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Wood JG, Jones BC, Jiang N, Chang C, Hosier S, Wickremesinghe P, Garcia M, Hartnett DA, Burhenn L, Neretti N, Helfand SL. Chromatin-modifying genetic interventions suppress age-associated transposable element activation and extend life span in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. PMID 27621458 DOI: 10.1073/pnas.1604621113  1
2016 Willmes DM, Helfand SL, Birkenfeld AL. The longevity transporter mIndy (Slc13a5) as a target for treating hepatic steatosis and insulin resistance. Aging. PMID 26928109  1
2015 Pu M, Ni Z, Wang M, Wang X, Wood JG, Helfand SL, Yu H, Lee SS. Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span. Genes & Development. 29: 718-31. PMID 25838541 DOI: 10.1101/gad.254144.114  1
2014 Gorbunova V, Boeke JD, Helfand SL, Sedivy JM. Human Genomics. Sleeping dogs of the genome. Science (New York, N.Y.). 346: 1187-8. PMID 25477445 DOI: 10.1126/science.aaa3177  1
2014 Whitaker R, Gil MP, Ding F, Tatar M, Helfand SL, Neretti N. Dietary switch reveals fast coordinated gene expression changes in Drosophila melanogaster. Aging. 6: 355-68. PMID 24864304  1
2014 Ding F, Gil MP, Franklin M, Ferreira J, Tatar M, Helfand SL, Neretti N. Transcriptional response to dietary restriction in Drosophila melanogaster. Journal of Insect Physiology. 69: 101-6. PMID 24819200 DOI: 10.1016/j.jinsphys.2014.05.002  1
2014 Zhu CT, Chang C, Reenan RA, Helfand SL. Indy gene variation in natural populations confers fitness advantage and life span extension through transposon insertion. Aging. 6: 58-69. PMID 24519859  1
2013 Wood JG, Helfand SL. Chromatin structure and transposable elements in organismal aging. Frontiers in Genetics. 4: 274. PMID 24363663 DOI: 10.3389/fgene.2013.00274  1
2013 Jiang N, Du G, Tobias E, Wood JG, Whitaker R, Neretti N, Helfand SL. Dietary and genetic effects on age-related loss of gene silencing reveal epigenetic plasticity of chromatin repression during aging. Aging. 5: 813-24. PMID 24243774  1
2013 Savva YA, Jepson JE, Chang YJ, Whitaker R, Jones BC, St Laurent G, Tackett MR, Kapranov P, Jiang N, Du G, Helfand SL, Reenan RA. RNA editing regulates transposon-mediated heterochromatic gene silencing. Nature Communications. 4: 2745. PMID 24201902 DOI: 10.1038/ncomms3745  1
2013 Whitaker R, Faulkner S, Miyokawa R, Burhenn L, Henriksen M, Wood JG, Helfand SL. Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner. Aging. 5: 682-91. PMID 24036492  1
2013 Wood JG, Whitaker R, Helfand SL. Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster. Methods in Molecular Biology (Clifton, N.J.). 1077: 57-67. PMID 24014399 DOI: 10.1007/978-1-62703-637-5_4  1
2012 Chamseddin KH, Khan SQ, Nguyen ML, Antosh M, Morris SN, Kolli S, Neretti N, Helfand SL, Bauer JH. takeout-dependent longevity is associated with altered Juvenile Hormone signaling. Mechanisms of Ageing and Development. 133: 637-46. PMID 22940452 DOI: 10.1016/j.mad.2012.08.004  1
2011 Shulman GI, Helfand SL. Indy knockdown in mice mimics elements of dietary restriction. Aging. 3: 701. PMID 21937764  1
2011 Birkenfeld AL, Lee HY, Guebre-Egziabher F, Alves TC, Jurczak MJ, Jornayvaz FR, Zhang D, Hsiao JJ, Martin-Montalvo A, Fischer-Rosinsky A, Spranger J, Pfeiffer AF, Jordan J, Fromm MF, König J, ... ... Helfand SL, et al. Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice. Cell Metabolism. 14: 184-95. PMID 21803289 DOI: 10.1016/j.cmet.2011.06.009  1
2011 Antosh M, Fox D, Helfand SL, Cooper LN, Neretti N. New comparative genomics approach reveals a conserved health span signature across species. Aging. 3: 576-83. PMID 21775776  1
2011 Antosh M, Whitaker R, Kroll A, Hosier S, Chang C, Bauer J, Cooper L, Neretti N, Helfand SL. Comparative transcriptional pathway bioinformatic analysis of dietary restriction, Sir2, p53 and resveratrol life span extension in Drosophila. Cell Cycle (Georgetown, Tex.). 10: 904-11. PMID 21325893 DOI: 10.4161/cc.10.6.14912  1
2010 Wood JG, Hillenmeyer S, Lawrence C, Chang C, Hosier S, Lightfoot W, Mukherjee E, Jiang N, Schorl C, Brodsky AS, Neretti N, Helfand SL. Chromatin remodeling in the aging genome of Drosophila. Aging Cell. 9: 971-8. PMID 20961390 DOI: 10.1111/j.1474-9726.2010.00624.x  1
2010 Baur JA, Chen D, Chini EN, Chua K, Cohen HY, de Cabo R, Deng C, Dimmeler S, Gius D, Guarente LP, Helfand SL, Imai S, Itoh H, Kadowaki T, Koya D, et al. Dietary restriction: standing up for sirtuins. Science (New York, N.Y.). 329: 1012-3; author reply. PMID 20798296 DOI: 10.1126/science.329.5995.1012  1
2010 Bauer J, Antosh M, Chang C, Schorl C, Kolli S, Neretti N, Helfand SL. Comparative transcriptional profiling identifies takeout as a gene that regulates life span. Aging. 2: 298-310. PMID 20519778 DOI: v2/n5/full/100146.html  1
2010 Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, ... ... Helfand SL, et al. Impact papers on aging in 2009. Aging. 2: 111-21. PMID 20351400 DOI: v2/n3/full/100132.html  1
2010 Bauer JH, Chang C, Bae G, Morris SN, Helfand SL. Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster. Mechanisms of Ageing and Development. 131: 193-201. PMID 20117129 DOI: 10.1016/j.mad.2010.01.007  1
2009 Fridell YW, Hoh M, Kréneisz O, Hosier S, Chang C, Scantling D, Mulkey DK, Helfand SL. Increased uncoupling protein (UCP) activity in Drosophila insulin-producing neurons attenuates insulin signaling and extends lifespan. Aging. 1: 699-713. PMID 20195385  1
2009 Bauer JH, Morris SN, Chang C, Flatt T, Wood JG, Helfand SL. dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster. Aging. 1: 38-48. PMID 19851477  1
2009 Bauer JH, Helfand SL. Sir2 and longevity: the p53 connection. Cell Cycle (Georgetown, Tex.). 8: 1821. PMID 19471127  1
2009 Wang PY, Neretti N, Whitaker R, Hosier S, Chang C, Lu D, Rogina B, Helfand SL. Long-lived Indy and calorie restriction interact to extend life span. Proceedings of the National Academy of Sciences of the United States of America. 106: 9262-7. PMID 19470468 DOI: 10.1073/pnas.0904115106  1
2009 Neretti N, Wang PY, Brodsky AS, Nyguyen HH, White KP, Rogina B, Helfand SL. Long-lived Indy induces reduced mitochondrial reactive oxygen species production and oxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 106: 2277-82. PMID 19164521 DOI: 10.1073/pnas.0812484106  1
2009 Helfand SL, Neretti N, Wang PY, Rogina B. Reply to Partridge et al.: Longevity of Drosophila Indy mutant is influenced by caloric intake and genetic background Proceedings of the National Academy of Sciences of the United States of America. 106: E54. DOI: 10.1073/pnas.0902947106  1
2007 Bauer JH, Chang C, Morris SN, Hozier S, Andersen S, Waitzman JS, Helfand SL. Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 104: 13355-60. PMID 17686972 DOI: 10.1073/pnas.0706121104  1
2006 Bauer JH, Helfand SL. The humble fly: what a model system can reveal about the human biology of aging. Medicine and Health, Rhode Island. 89: 314-5. PMID 17036696  1
2006 Bauer JH, Helfand SL. New tricks of an old molecule: lifespan regulation by p53. Aging Cell. 5: 437-40. PMID 16968311 DOI: 10.1111/j.1474-9726.2006.00228.x  1
2006 Knauf F, Mohebbi N, Teichert C, Herold D, Rogina B, Helfand S, Gollasch M, Luft FC, Aronson PS. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates. The Biochemical Journal. 397: 25-9. PMID 16608441 DOI: 10.1042/BJ20060409  1
2006 Sánchez-Blanco A, Fridell YW, Helfand SL. Involvement of Drosophila uncoupling protein 5 in metabolism and aging. Genetics. 172: 1699-710. PMID 16387864 DOI: 10.1534/genetics.105.053389  1
2006 Cowen T, Miller R, Sedivy J, Antebi A, Helfand S. Editorial Aging Cell. 5: 575. DOI: 10.1111/j.1474-9726.2006.00253.x  1
2006 Cowen T, Miller R, Sedivy J, Antebi A, Helfand S, Waller S. Welcome to the new Editorial Board Aging Cell. 5: 201. DOI: 10.1111/j.1474-9726.2006.00217.x  1
2005 Bauer JH, Poon PC, Glatt-Deeley H, Abrams JM, Helfand SL. Neuronal expression of p53 dominant-negative proteins in adult Drosophila melanogaster extends life span. Current Biology : Cb. 15: 2063-8. PMID 16303568 DOI: 10.1016/j.cub.2005.10.051  1
2005 Bross TG, Rogina B, Helfand SL. Behavioral, physical, and demographic changes in Drosophila populations through dietary restriction. Aging Cell. 4: 309-17. PMID 16300483 DOI: 10.1111/j.1474-9726.2005.00181.x  1
2005 Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL. Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly. Cell Metabolism. 1: 145-52. PMID 16054055 DOI: 10.1016/j.cmet.2005.01.005  1
2005 Zheng J, Mutcherson R, Helfand SL. Calorie restriction delays lipid oxidative damage in Drosophila melanogaster. Aging Cell. 4: 209-16. PMID 16026335 DOI: 10.1111/j.1474-9726.2005.00159.x  1
2004 Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proceedings of the National Academy of Sciences of the United States of America. 101: 15998-6003. PMID 15520384 DOI: 10.1073/pnas.0404184101  1
2004 Fridell YW, Sánchez-Blanco A, Silvia BA, Helfand SL. Functional characterization of a Drosophila mitochondrial uncoupling protein. Journal of Bioenergetics and Biomembranes. 36: 219-28. PMID 15337852 DOI: 10.1023/B:JOBB.0000031973.20153.c6  1
2004 Bauer JH, Goupil S, Garber GB, Helfand SL. An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 101: 12980-5. PMID 15328413 DOI: 10.1073/pnas.0403493101  1
2004 Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature. 430: 686-9. PMID 15254550 DOI: 10.1038/nature02789  1
2003 Helfand SL, Rogina B. Genetics of aging in the fruit fly, Drosophila melanogaster. Annual Review of Genetics. 37: 329-48. PMID 14616064 DOI: 10.1146/annurev.genet.37.040103.095211  1
2003 Butler RN, Austad SN, Barzilai N, Braun A, Helfand S, Larsen PL, McCormick AM, Perls TT, Shuldiner AR, Sprott RL, Warner HR. Longevity genes: from primitive organisms to humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 58: 581-4. PMID 12865472  1
2003 Helfand SL, Rogina B. From genes to aging in Drosophila. Advances in Genetics. 49: 67-109. PMID 12779251 DOI: 10.1016/S0065-2660(03)01002-2  1
2003 Marden JH, Rogina B, Montooth KL, Helfand SL. Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Proceedings of the National Academy of Sciences of the United States of America. 100: 3369-73. PMID 12626742 DOI: 10.1073/pnas.0634985100  1
2003 Helfand SL, Rogina B. Molecular genetics of aging in the fly: is this the end of the beginning? Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 25: 134-41. PMID 12539239 DOI: 10.1002/bies.10225  1
2003 Helfand SL, Inouye SK. Aging, life span, genetics and the fruit fly Clinical Neuroscience Research. 2: 270-278. DOI: 10.1016/S1566-2772(03)00003-3  1
2002 Rogina B, Helfand SL, Frankel S. Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science (New York, N.Y.). 298: 1745. PMID 12459580 DOI: 10.1126/science.1078986  1
2002 Knauf F, Rogina B, Jiang Z, Aronson PS, Helfand SL. Functional characterization and immunolocalization of the transporter encoded by the life-extending gene Indy. Proceedings of the National Academy of Sciences of the United States of America. 99: 14315-9. PMID 12391301 DOI: 10.1073/pnas.222531899  1
2002 Helfand SL, Inouye SK. Rejuvenating views of the ageing process. Nature Reviews. Genetics. 3: 149-53. PMID 11836509 DOI: 10.1038/nrg726  1
2002 Helfand SL. Neurobiology. Chaperones take flight. Science (New York, N.Y.). 295: 809-10. PMID 11823628 DOI: 10.1126/science.1069544  1
2002 Hoopengardner B, Helfand SL. Temperature compensation and temporal expression mediated by an enhancer element in Drosophila. Mechanisms of Development. 110: 27-37. PMID 11744366 DOI: 10.1016/S0925-4773(01)00588-3  1
2000 Rogina B, Helfand SL. Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster. Biogerontology. 1: 163-9. PMID 11707932  1
2000 Rogina B, Reenan RA, Nilsen SP, Helfand SL. Extended life-span conferred by cotransporter gene mutations in Drosophila. Science (New York, N.Y.). 290: 2137-40. PMID 11118146 DOI: 10.1126/science.290.5499.2137  1
2000 Helfand SL, Rogina B. Regulation of gene expression during aging. Results and Problems in Cell Differentiation. 29: 67-80. PMID 10838695  1
1998 Rogina B, Vaupel JW, Partridge L, Helfand SL. Regulation of gene expression is preserved in aging Drosophila melanogaster. Current Biology : Cb. 8: 475-8. PMID 9550706  1
1997 Rogina B, Helfand SL. Spatial and temporal pattern of expression of the wingless and engrailed genes in the adult antenna is regulated by age-dependent mechanisms. Mechanisms of Development. 63: 89-97. PMID 9178259 DOI: 10.1016/S0925-4773(97)00033-6  1
1997 Rogina B, Benzer S, Helfand SL. Drosophila drop-dead mutations accelerate the time course of age-related markers. Proceedings of the National Academy of Sciences of the United States of America. 94: 6303-6. PMID 9177212  1
1996 Blake KJ, Hoopengardner B, Centurion A, Helfand SL. A molecular marker confirms that the rate of adult maturation is largely independent of the rate of pre-adult development in Drosophila melanogaster. Developmental Genetics. 18: 125-30. PMID 8934874 DOI: 10.1002/(SICI)1520-6408(1996)18:2<125::AID-DVG5>3.0.CO;2-B  1
1996 Rogina B, Helfand SL. Timing of expression of a gene in the adult Drosophila is regulated by mechanisms independent of temperature and metabolic rate. Genetics. 143: 1643-51. PMID 8844152  1
1996 Helfand SL, Naprta B. The expression of a reporter protein, beta-galactosidase, is preserved during maturation and aging in some cells of the adult Drosophila melanogaster. Mechanisms of Development. 55: 45-51. PMID 8734498 DOI: 10.1016/0925-4773(95)00489-0  1
1995 Rogina B, Helfand SL. Regulation of gene expression is linked to life span in adult Drosophila. Genetics. 141: 1043-8. PMID 8582611  1
1995 Blake KJ, Rogina B, Centurion A, Helfand SL. Changes in gene expression during post-eclosional development in the olfactory system of Drosophila melanogaster. Mechanisms of Development. 52: 179-85. PMID 8541207 DOI: 10.1016/0925-4773(95)00398-K  1
1995 Helfand SL, Blake KJ, Rogina B, Stracks MD, Centurion A, Naprta B. Temporal patterns of gene expression in the antenna of the adult Drosophila melanogaster. Genetics. 140: 549-55. PMID 7498736  1
1991 Irvine KD, Helfand SL, Hogness DS. The large upstream control region of the Drosophila homeotic gene Ultrabithorax. Development (Cambridge, England). 111: 407-24. PMID 1680046  1
1989 Woodard C, Huang T, Sun H, Helfand SL, Carlson J. Genetic analysis of olfactory behavior in Drosophila: a new screen yields the ota mutants. Genetics. 123: 315-26. PMID 2511068  1
1989 McKenna M, Monte P, Helfand SL, Woodard C, Carlson J. A simple chemosensory response in Drosophila and the isolation of acj mutants in which it is affected. Proceedings of the National Academy of Sciences of the United States of America. 86: 8118-22. PMID 2510161  1
1989 Helfand SL, Carlson JR. Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect. Proceedings of the National Academy of Sciences of the United States of America. 86: 2908-12. PMID 2495539  1
1985 Hogness DS, Lipshitz HD, Beachy PA, Peattie DA, Saint RB, Goldschmidt-Clermont M, Harte PJ, Gavis ER, Helfand SL. Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harbor Symposia On Quantitative Biology. 50: 181-94. PMID 3938361  1
1985 Beachy PA, Helfand SL, Hogness DS. Segmental distribution of bithorax complex proteins during Drosophila development. Nature. 313: 545-51. PMID 3918274 DOI: 10.1038/313545a0  1
1985 Bastiani MJ, Doe CQ, Helfand SL, Goodman CS. Neuronal specificity and growth cone guidance in grasshopper and Drosophila embryos Trends in Neurosciences. 8: 257-266. DOI: 10.1016/0166-2236(85)90099-2  1
1984 Goodman CS, Bastiani MJ, Doe CQ, du Lac S, Helfand SL, Kuwada JY, Thomas JB. Cell recognition during neuronal development. Science (New York, N.Y.). 225: 1271-9. PMID 6474176  1
1983 Roder JC, Todd RF, Rubin P, Haliotis T, Helfand SL, Werkmeister J, Pross HF, Boxer LA, Schlossman SF, Fauci AS. The Chediak-Higashi gene in humans. III. Studies on the mechanisms of NK impairment. Clinical and Experimental Immunology. 51: 359-68. PMID 6839545  1
1983 Werkmeister J, Helfand S, Roder J, Pross H. The chemiluminescence response of human natural killer cells. II. Association of a decreased response with low natural killer activity. European Journal of Immunology. 13: 514-20. PMID 6574914 DOI: 10.1002/eji.1830130615  1
1983 McGarry RC, Helfand SL, Quarles RH, Roder JC. Recognition of myelin-associated glycoprotein by the monoclonal antibody HNK-1. Nature. 306: 376-8. PMID 6196641 DOI: 10.1038/306376a0  1
1983 Helfand SL, Werkmeister J, Pross H, Roder JC. Oxygen intermediates are required for interferon activation of NK cells. Journal of Interferon Research. 3: 143-51. PMID 6192183  1
1982 Werkmeister J, Helfand SL, Haliotis T, Rubin P, Pross H, Roder J. Tumor cell differentiation modulates susceptibility to natural killer cells. Cellular Immunology. 69: 122-7. PMID 6955028 DOI: 10.1016/0008-8749(82)90056-9  1
1982 Roder JC, Helfand SL, Werkmeister J, McGarry R, Beaumont TJ, Duwe A. Oxygen intermediates are triggered early in the cytolytic pathway of human NK cells. Nature. 298: 569-72. PMID 6178976 DOI: 10.1038/298569a0  1
1982 Helfand SL, Werkmeister J, Roder JC. Chemiluminescence response of human natural killer cells. I. The relationship between target cell binding, chemiluminescence, and cytolysis. The Journal of Experimental Medicine. 156: 492-505. PMID 6178787  1
1982 Werkmeister JA, Helfand SL, Haliotis T, Pross HF, Roder JC. The effect of target cell differentiation on human natural killer cell activity: a specific defect in target cell binding and early activation events. Journal of Immunology (Baltimore, Md. : 1950). 129: 413-8. PMID 6177758  1
1978 Helfand SL, Riopelle RJ, Wessells NK. Non-equivalence of conditioned medium and nerve growth factor for sympathetic, parasympathetic, and sensory neurons. Experimental Cell Research. 113: 39-45. PMID 25192 DOI: 10.1016/0014-4827(78)90085-X  1
1976 Helfand SL, Smith GA, Wessells NK. Survival and development in culture of dissociated parasympathetic neurons from ciliary ganglia. Developmental Biology. 50: 541-7. PMID 1278600 DOI: 10.1016/0012-1606(76)90174-3  1
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