Mark T Keating - Publications

Affiliations: 
Cell Biology and Pathology Harvard Medical School, Boston, MA, United States 

109 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2007 JaźwiÅ„ska A, Badakov R, Keating MT. Activin-betaA signaling is required for zebrafish fin regeneration. Current Biology : Cb. 17: 1390-5. PMID 17683938 DOI: 10.1016/j.cub.2007.07.019  1
2007 Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Medicine. 13: 962-9. PMID 17632525 DOI: 10.1038/nm1619  1
2007 Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann SH, Timothy KW, Keating MT, Daut J, Sanguinetti MC, Splawski I. Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. Cardiovascular Research. 75: 748-57. PMID 17568571 DOI: 10.1016/j.cardiores.2007.05.010  1
2007 Keating M. Mending broken hearts: The future of drug-based cardiac regeneration Future Cardiology. 3: 493-495. DOI: 10.2217/14796678.3.5.493  1
2006 Schebesta M, Lien CL, Engel FB, Keating MT. Transcriptional profiling of caudal fin regeneration in zebrafish. Thescientificworldjournal. 6: 38-54. PMID 17205186 DOI: 10.1100/tsw.2006.326  1
2006 Engel FB, Hsieh PC, Lee RT, Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 103: 15546-51. PMID 17032753 DOI: 10.1073/pnas.0607382103  1
2006 Engel FB, Schebesta M, Keating MT. Anillin localization defect in cardiomyocyte binucleation. Journal of Molecular and Cellular Cardiology. 41: 601-12. PMID 16889791 DOI: 10.1016/j.yjmcc.2006.06.012  1
2006 Lien CL, Schebesta M, Makino S, Weber GJ, Keating MT. Gene expression analysis of zebrafish heart regeneration. Plos Biology. 4: e260. PMID 16869712 DOI: 10.1371/journal.pbio.0040260  1
2006 Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. The Journal of Biological Chemistry. 281: 22085-91. PMID 16754686 DOI: 10.1074/jbc.M603316200  1
2006 Bayliss PE, Bellavance KL, Whitehead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O'Reilly T, Wood JM, Roberts TM, Chan J. Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2: 265-73. PMID 16565716 DOI: 10.1038/nchembio778  1
2006 Stevenson TJ, Vinarsky V, Atkinson DL, Keating MT, Odelberg SJ. Tissue inhibitor of metalloproteinase 1 regulates matrix metalloproteinase activity during newt limb regeneration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 235: 606-16. PMID 16372340 DOI: 10.1002/dvdy.20654  1
2006 Kiehl TR, Nechiporuk A, Figueroa KP, Keating MT, Huynh DP, Pulst SM. Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochemical and Biophysical Research Communications. 339: 17-24. PMID 16293225 DOI: 10.1016/j.bbrc.2005.10.186  1
2005 Whitehead GG, Makino S, Lien CL, Keating MT. fgf20 is essential for initiating zebrafish fin regeneration. Science (New York, N.Y.). 310: 1957-60. PMID 16373575 DOI: 10.1126/science.1117637  1
2005 Makino S, Whitehead GG, Lien CL, Kim S, Jhawar P, Kono A, Kawata Y, Keating MT. Heat-shock protein 60 is required for blastema formation and maintenance during regeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 14599-604. PMID 16204379 DOI: 10.1073/pnas.0507408102  1
2005 Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, Keating MT. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes & Development. 19: 1175-87. PMID 15870258 DOI: 10.1101/gad.1306705  1
2005 Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating MT. Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Sciences of the United States of America. 102: 8089-96; discussion . PMID 15863612 DOI: 10.1073/pnas.0502506102  1
2005 Vinarsky V, Atkinson DL, Stevenson TJ, Keating MT, Odelberg SJ. Normal newt limb regeneration requires matrix metalloproteinase function. Developmental Biology. 279: 86-98. PMID 15708560 DOI: 10.1016/j.ydbio.2004.12.003  1
2004 Ackerman MJ, Splawski I, Makielski JC, Tester DJ, Will ML, Timothy KW, Keating MT, Jones G, Chadha M, Burrow CR, Stephens JC, Xu C, Judson R, Curran ME. Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 1: 600-7. PMID 15851227 DOI: 10.1016/j.hrthm.2004.07.013  1
2004 Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Molecular Cell. 16: 867-80. PMID 15610731 DOI: 10.1016/j.molcel.2004.11.039  1
2004 Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell. 119: 19-31. PMID 15454078 DOI: 10.1016/j.cell.2004.09.011  1
2004 Zhang L, Vincent GM, Baralle M, Baralle FE, Anson BD, Benson DW, Whiting B, Timothy KW, Carlquist J, January CT, Keating MT, Splawski I. An intronic mutation causes long QT syndrome. Journal of the American College of Cardiology. 44: 1283-91. PMID 15364333 DOI: 10.1016/j.jacc.2004.06.045  1
2004 Keating MT. Genetic approaches to disease and regeneration. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 795-8. PMID 15293807 DOI: 10.1098/rstb.2004.1469  1
2004 Poss KD, Nechiporuk A, Stringer KF, Lee C, Keating MT. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes & Development. 18: 1527-32. PMID 15231734 DOI: 10.1101/gad.1182604  1
2004 Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proceedings of the National Academy of Sciences of the United States of America. 101: 9137-42. PMID 15178757 DOI: 10.1073/pnas.0402546101  1
2004 Glatter KA, Wang Q, Keating M, Chen S, Chiamvimonvat N, Scheinman MM. Effectiveness of sotalol treatment in symptomatic Brugada syndrome American Journal of Cardiology. 93: 1320-1322. PMID 15135718 DOI: 10.1016/j.amjcard.2004.02.023  1
2004 Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, Timur AA, Keating MT, Kirsch GE. The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. Journal of Medical Genetics. 41: e66. PMID 15121794  1
2004 Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC. Compound mutations: a common cause of severe long-QT syndrome. Circulation. 109: 1834-41. PMID 15051636 DOI: 10.1161/01.CIR.0000125524.34234.13  1
2004 Goldstein SAN, Keating MT, Sanguinetti MC. Cardiac Arrhythmias: Inherited Molecular Mechanisms Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 336-348. DOI: 10.1016/B978-0-7216-9428-3.50024-X  1
2003 Zareba W, Moss AJ, Sheu G, Kaufman ES, Priori S, Vincent GM, Towbin JA, Benhorin J, Schwartz PJ, Napolitano C, Hall WJ, Keating MT, Qi M, Robinson J, Andrews ML, et al. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. Journal of Cardiovascular Electrophysiology. 14: 1149-53. PMID 14678125 DOI: 10.1046/j.1540-8167.2003.03177.x  1
2003 Morris CA, Mervis CB, Hobart HH, Gregg RG, Bertrand J, Ensing GJ, Sommer A, Moore CA, Hopkin RJ, Spallone PA, Keating MT, Osborne L, Kimberley KW, Stock AD. GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Williams syndrome region. American Journal of Medical Genetics. Part A. 123: 45-59. PMID 14556246 DOI: 10.1002/ajmg.a.20496  1
2003 Nechiporuk A, Poss KD, Johnson SL, Keating MT. Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. Developmental Biology. 258: 291-306. PMID 12798289 DOI: 10.1016/S0012-1606(03)00129-5  1
2003 Poss KD, Keating MT, Nechiporuk A. Tales of regeneration in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 226: 202-10. PMID 12557199 DOI: 10.1002/dvdy.10220  1
2003 Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li DY. A critical role for elastin signaling in vascular morphogenesis and disease. Development (Cambridge, England). 130: 411-23. PMID 12466207 DOI: 10.1242/dev.00223  1
2002 Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science (New York, N.Y.). 298: 2188-90. PMID 12481136 DOI: 10.1126/science.1077857  1
2002 Poss KD, Nechiporuk A, Hillam AM, Johnson SL, Keating MT. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development (Cambridge, England). 129: 5141-9. PMID 12399306  1
2002 Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (New York, N.Y.). 297: 1333-6. PMID 12193783 DOI: 10.1126/science.1073569  1
2002 Nechiporuk A, Keating MT. A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration. Development (Cambridge, England). 129: 2607-17. PMID 12015289  1
2002 Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, et al. Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation. 105: 794-9. PMID 11854117 DOI: 10.1161/hc0702.105124  1
2002 Olson TM, Illenberger S, Kishimoto NY, Huttelmaier S, Keating MT, Jockusch BM. Metavinculin mutations alter actin interaction in dilated cardiomyopathy. Circulation. 105: 431-7. PMID 11815424 DOI: 10.1161/hc0402.102930  1
2001 McGann CJ, Odelberg SJ, Keating MT. Mammalian myotube dedifferentiation induced by newt regeneration extract. Proceedings of the National Academy of Sciences of the United States of America. 98: 13699-704. PMID 11717431 DOI: 10.1073/pnas.221297398  1
2001 Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC. Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation. 104: 1071-5. PMID 11524404  1
2001 Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell. 104: 569-80. PMID 11239413 DOI: 10.1016/S0092-8674(01)00243-4  1
2001 Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 103: 89-95. PMID 11136691  1
2001 Nechiporuk T, Urness LD, Keating MT. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. The Journal of Biological Chemistry. 276: 4150-7. PMID 11050079 DOI: 10.1074/jbc.M004814200  1
2000 Odelberg SJ, Kollhoff A, Keating MT. Dedifferentiation of mammalian myotubes induced by msx1. Cell. 103: 1099-109. PMID 11163185 DOI: 10.1016/S0092-8674(00)00212-9  1
2000 Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Splawski I, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, ... ... Keating MT, et al. Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation. 102: 2849-55. PMID 11104743  1
2000 Poss KD, Shen J, Keating MT. Induction of lef1 during zebrafish fin regeneration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 219: 282-6. PMID 11002347 DOI: 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1045>3.0.CO;2-C  1
2000 Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, Moss AJ, Schwartz PJ, Towbin JA, Vincent GM, Keating MT. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation. 102: 1178-85. PMID 10973849  1
2000 Wendel DP, Taylor DG, Albertine KH, Keating MT, Li DY. Impaired distal airway development in mice lacking elastin. American Journal of Respiratory Cell and Molecular Biology. 23: 320-6. PMID 10970822 DOI: 10.1165/ajrcmb.23.3.3906  1
2000 Poss KD, Shen J, Nechiporuk A, McMahon G, Thisse B, Thisse C, Keating MT. Roles for Fgf signaling during zebrafish fin regeneration. Developmental Biology. 222: 347-58. PMID 10837124 DOI: 10.1006/dbio.2000.9722  1
1999 Nechiporuk A, Finney JE, Keating MT, Johnson SL. Assessment of polymorphism in zebrafish mapping strains. Genome Research. 9: 1231-8. PMID 10613846 DOI: 10.1101/gr.9.12.1231  1
1999 Faury G, Maher GM, Li DY, Keating MT, Mecham RP, Boyle WA. Relation between outer and luminal diameter in cannulated arteries. The American Journal of Physiology. 277: H1745-53. PMID 10564127  1
1999 Franqueza L, Lin M, Shen J, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. The Journal of Biological Chemistry. 274: 21063-70. PMID 10409658 DOI: 10.1074/jbc.274.30.21063  1
1999 Wang Z, Tristani-Firouzi M, Xu Q, Lin M, Keating MT, Sanguinetti MC. Functional effects of mutations in KvLQT1 that cause long QT syndrome. Journal of Cardiovascular Electrophysiology. 10: 817-26. PMID 10376919  1
1999 Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 97: 175-87. PMID 10219239  1
1999 Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. The Journal of Biological Chemistry. 274: 10113-8. PMID 10187793 DOI: 10.1074/jbc.274.15.10113  1
1998 Meng X, Lu X, Li Z, Green ED, Massa H, Trask BJ, Morris CA, Keating MT. Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes. Human Genetics. 103: 590-9. PMID 9860302 DOI: 10.1007/s004390050874  1
1998 Lu X, Meng X, Morris CA, Keating MT. A novel human gene, WSTF, is deleted in Williams syndrome. Genomics. 54: 241-9. PMID 9828126 DOI: 10.1006/geno.1998.5578  1
1998 Li DY, Faury G, Taylor DG, Davis EC, Boyle WA, Mecham RP, Stenzel P, Boak B, Keating MT. Novel arterial pathology in mice and humans hemizygous for elastin. The Journal of Clinical Investigation. 102: 1783-7. PMID 9819363 DOI: 10.1172/JCI4487  1
1998 Meng X, Lu X, Morris CA, Keating MT. A novel human gene FKBP6 is deleted in Williams syndrome. Genomics. 52: 130-7. PMID 9782077 DOI: 10.1006/geno.1998.5412  1
1998 Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Robinson JL, Priori SG, Benhorin J, Locati EH, Towbin JA, Keating MT, Lehmann MH, Hall WJ. Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. The New England Journal of Medicine. 339: 960-5. PMID 9753711 DOI: 10.1056/NEJM199810013391404  1
1998 Splawski I, Shen J, Timothy KW, Vincent GM, Lehmann MH, Keating MT. Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. Genomics. 51: 86-97. PMID 9693036 DOI: 10.1006/geno.1998.5361  1
1998 Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, Keating MT. Elastin is an essential determinant of arterial morphogenesis. Nature. 393: 276-80. PMID 9607766 DOI: 10.1038/30522  1
1998 Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science (New York, N.Y.). 280: 750-2. PMID 9563954 DOI: 10.1126/science.280.5364.750  1
1998 Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, ... Keating MT, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 392: 293-6. PMID 9521325 DOI: 10.1038/32675  1
1997 Olson TM, Keating MT. Defining the molecular genetic basis of idiopathic dilated cardiomyopathy. Trends in Cardiovascular Medicine. 7: 60-3. PMID 21235865 DOI: 10.1016/S1050-1738(96)00139-9  1
1997 Keating MT. On the trail of genetic culprits in Williams syndrome. Cardiovascular Research. 36: 134-7. PMID 9463625 DOI: 10.1016/S0008-6363(97)00027-8  1
1997 Splawski I, Tristani-Firouzi M, Lehmann MH, Sanguinetti MC, Keating MT. Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nature Genetics. 17: 338-40. PMID 9354802 DOI: 10.1038/ng1197-338  1
1997 Qian N, Frank D, O'Keefe D, Dao D, Zhao L, Yuan L, Wang Q, Keating M, Walsh C, Tycko B. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Human Molecular Genetics. 6: 2021-9. PMID 9328465 DOI: 10.1093/hmg/6.12.2021  1
1997 Bitner-Glindzicz M, Tyson J, Jamieson R, Keating MT. Molecular basis of the long-QT syndrome [5] (multiple letters) New England Journal of Medicine. 337: 1011-1013. PMID 9312674 DOI: 10.1056/NEJM199710023371416  1
1997 Splawski I, Timothy KW, Vincent GM, Atkinson DL, Keating MT. George M. Cober Lecturer: Mark T. Keating. Molecular basis of the long-QT syndrome associated with deafness. Proceedings of the Association of American Physicians. 109: 504-11. PMID 9285950  1
1997 Li DY, Toland AE, Boak BB, Atkinson DL, Ensing GJ, Morris CA, Keating MT. Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis. Human Molecular Genetics. 6: 1021-8. PMID 9215670 DOI: 10.1093/hmg/6.7.1021  1
1997 Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics. 42: 33-7. PMID 9177773 DOI: 10.1006/geno.1997.4712  1
1997 Splawski I, Timothy KW, Vincent GM, Atkinson DL, Keating MT. Molecular basis of the long-QT syndrome associated with deafness. The New England Journal of Medicine. 336: 1562-7. PMID 9164812 DOI: 10.1056/NEJM199705293362204  1
1997 Zou A, Curran ME, Keating MT, Sanguinetti MC. Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. The American Journal of Physiology. 272: H1309-14. PMID 9087606  1
1997 Lehmann MH, Timothy KW, Frankovich D, Fromm BS, Keating M, Locati EH, Taggart RT, Towbin JA, Moss AJ, Schwartz PJ, Vincent GM. Age-gender influence on the rate-corrected QT interval and the QT-heart rate relation in families with genotypically characterized long QT syndrome. Journal of the American College of Cardiology. 29: 93-9. PMID 8996300 DOI: 10.1016/S0735-1097(96)00454-8  1
1997 Sanguinetti MC, Keating MT. Role of delayed rectifier potassium channels in cardiac repolarization and arrhythmias News in Physiological Sciences. 12: 152-157.  1
1997 Keating MT, Curran ME, Wang Q. Long QT syndrome genes Biotechnology Advances. 15: 724.  1
1996 Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature. 384: 80-3. PMID 8900283 DOI: 10.1038/384080a0  1
1996 Keating MT, Sanguinetti MC. Pathophysiology of ion channel mutations. Current Opinion in Genetics & Development. 6: 326-33. PMID 8791523 DOI: 10.1016/S0959-437X(96)80010-4  1
1996 Compton SJ, Lux RL, Ramsey MR, Strelich KR, Sanguinetti MC, Green LS, Keating MT, Mason JW. Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium. Circulation. 94: 1018-22. PMID 8790040  1
1996 Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC. Fast inactivation causes rectification of the IKr channel. The Journal of General Physiology. 107: 611-9. PMID 8740374  1
1996 Sanguinetti MC, Curran ME, Spector PS, Keating MT. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 93: 2208-12. PMID 8700910 DOI: 10.1073/pnas.93.5.2208  1
1996 Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, ... Keating MT, et al. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. Cell. 86: 59-69. PMID 8689688 DOI: 10.1016/S0092-8674(00)80077-X  1
1996 Wang Q, Li Z, Shen J, Keating MT. Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics. 34: 9-16. PMID 8661019 DOI: 10.1006/geno.1996.0236  1
1996 Dumaine R, Wang Q, Keating MT, Hartmann HA, Schwartz PJ, Brown AM, Kirsch GE. Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation Research. 78: 916-24. PMID 8620612  1
1996 Keating MT, Sanguinetti MC. Molecular genetic insights into cardiovascular disease. Science (New York, N.Y.). 272: 681-5. PMID 8614827  1
1996 Spector PS, Curran ME, Keating MT, Sanguinetti MC. Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circulation Research. 78: 499-503. PMID 8593709  1
1996 Keating MT. The long QT syndrome. A review of recent molecular genetic and physiologic discoveries. Medicine. 75: 1-5. PMID 8569466 DOI: 10.1097/00005792-199601000-00001  1
1996 Olson TM, Keating MT. Mapping a cardiomyopathy locus to chromosome 3p22-p25. The Journal of Clinical Investigation. 97: 528-32. PMID 8567977 DOI: 10.1172/JCI118445  1
1996 Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, ... ... Keating MT, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nature Genetics. 12: 17-23. PMID 8528244 DOI: 10.1038/ng0196-17  1
1995 Wang Q, Shen J, Li Z, Timothy K, Vincent GM, Priori SG, Schwartz PJ, Keating MT. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Human Molecular Genetics. 4: 1603-7. PMID 8541846  1
1995 Schwartz PJ, Priori SG, Locati EH, Napolitano C, Cantù F, Towbin JA, Keating MT, Hammoude H, Brown AM, Chen LS. Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation. 92: 3381-6. PMID 8521555  1
1995 Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 80: 805-11. PMID 7889574 DOI: 10.1016/0092-8674(95)90359-3  1
1995 Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 80: 795-803. PMID 7889573 DOI: 10.1016/0092-8674(95)90358-5  1
1995 Landes GM, Curran ME, Keating MT. Molecular characterization and refined genomic localization of three human potassium ion channel genes. Cytogenetics and Cell Genetics. 70: 280-4. PMID 7789190 DOI: 10.1159/000134052  1
1995 Keating MT. Genetic approaches to cardiovascular disease. Supravalvular aortic stenosis, Williams syndrome, and long-QT syndrome. Circulation. 92: 142-7. PMID 7788908  1
1995 Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81: 299-307. PMID 7736582 DOI: 10.1016/0092-8674(95)90340-2  1
1995 Nickerson E, Greenberg F, Keating MT, McCaskill C, Shaffer LG. Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome. American Journal of Human Genetics. 56: 1156-61. PMID 7726172  1
1995 Keating MT. Molecular genetics of long QT syndrome. Society of General Physiologists Series. 50: 53-60. PMID 7676324  1
1995 Moss AJ, Zareba W, Benhorin J, Locati EH, Hall WJ, Robinson JL, Schwartz PJ, Towbin JA, Vincent GM, Lehmann MH. ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. Circulation. 92: 2929-34. PMID 7586261  1
1995 Marks ML, Trippel DL, Keating MT. Long QT syndrome associated with syndactyly identified in females. The American Journal of Cardiology. 76: 744-5. PMID 7572644 DOI: 10.1016/S0002-9149(99)80216-1  1
1994 Ewart AK, Jin W, Atkinson D, Morris CA, Keating MT. Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. The Journal of Clinical Investigation. 93: 1071-7. PMID 8132745 DOI: 10.1172/JCI117057  1
1994 Wang Q, Keating MT. Isolation of P1 insert ends by direct sequencing. Biotechniques. 17: 282, 284. PMID 7980927  1
1994 Jiang C, Atkinson D, Towbin JA, Splawski I, Lehmann MH, Li H, Timothy K, Taggart RT, Schwartz PJ, Vincent GM, Moss AJ, Keating MT. Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity Nature Genetics. 8: 141-147. PMID 7842012 DOI: 10.1038/ng1094-141  1
1993 Phromchotikul T, Browne DL, Curran ME, Keating MT, Litt M. Dinucleotide repeat polymorphism at the KCNA5 locus. Human Molecular Genetics. 2: 1512. PMID 8242092 DOI: 10.1093/hmg/2.9.1512-a  1
1993 Curran ME, Atkinson DL, Ewart AK, Morris CA, Leppert MF, Keating MT. The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis. Cell. 73: 159-68. PMID 8096434 DOI: 10.1016/0092-8674(93)90168-P  1
1993 Ewart AK, Morris CA, Atkinson D, Jin W, Sternes K, Spallone P, Stock AD, Leppert M, Keating MT. Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nature Genetics. 5: 11-6. PMID 7693128 DOI: 10.1038/ng0993-11  1
1992 Curran ME, Landes GM, Keating MT. Molecular cloning, characterization, and genomic localization of a human potassium channel gene. Genomics. 12: 729-37. PMID 1349297 DOI: 10.1016/0888-7543(92)90302-9  1
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