Mark T Keating - Publications

Affiliations: 
Cell Biology and Pathology Harvard Medical School, Boston, MA, United States 

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Year Citation  Score
2007 JaźwiÅ„ska A, Badakov R, Keating MT. Activin-betaA signaling is required for zebrafish fin regeneration. Current Biology : Cb. 17: 1390-5. PMID 17683938 DOI: 10.1016/J.Cub.2007.07.019  0.394
2007 Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann SH, Timothy KW, Keating MT, Daut J, Sanguinetti MC, Splawski I. Impaired interaction between the slide helix and the C-terminus of Kir2.1: a novel mechanism of Andersen syndrome. Cardiovascular Research. 75: 748-57. PMID 17568571 DOI: 10.1016/J.Cardiores.2007.05.010  0.363
2006 Schebesta M, Lien CL, Engel FB, Keating MT. Transcriptional profiling of caudal fin regeneration in zebrafish. Thescientificworldjournal. 6: 38-54. PMID 17205186 DOI: 10.1100/Tsw.2006.326  0.381
2006 Engel FB, Hsieh PC, Lee RT, Keating MT. FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proceedings of the National Academy of Sciences of the United States of America. 103: 15546-51. PMID 17032753 DOI: 10.1073/Pnas.0607382103  0.317
2006 Tseng AS, Engel FB, Keating MT. The GSK-3 inhibitor BIO promotes proliferation in mammalian cardiomyocytes. Chemistry & Biology. 13: 957-63. PMID 16984885 DOI: 10.1016/J.Chembiol.2006.08.004  0.321
2006 Lien CL, Schebesta M, Makino S, Weber GJ, Keating MT. Gene expression analysis of zebrafish heart regeneration. Plos Biology. 4: e260. PMID 16869712 DOI: 10.1371/Journal.Pbio.0040260  0.384
2006 Splawski I, Yoo DS, Stotz SC, Cherry A, Clapham DE, Keating MT. CACNA1H mutations in autism spectrum disorders. The Journal of Biological Chemistry. 281: 22085-91. PMID 16754686 DOI: 10.1074/Jbc.M603316200  0.344
2006 Bayliss PE, Bellavance KL, Whitehead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O'Reilly T, Wood JM, Roberts TM, Chan J. Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2: 265-73. PMID 16565716 DOI: 10.1038/Nchembio778  0.33
2006 Kiehl TR, Nechiporuk A, Figueroa KP, Keating MT, Huynh DP, Pulst SM. Generation and characterization of Sca2 (ataxin-2) knockout mice. Biochemical and Biophysical Research Communications. 339: 17-24. PMID 16293225 DOI: 10.1016/J.Bbrc.2005.10.186  0.629
2005 Whitehead GG, Makino S, Lien CL, Keating MT. fgf20 is essential for initiating zebrafish fin regeneration. Science (New York, N.Y.). 310: 1957-60. PMID 16373575 DOI: 10.1126/Science.1117637  0.424
2005 Makino S, Whitehead GG, Lien CL, Kim S, Jhawar P, Kono A, Kawata Y, Keating MT. Heat-shock protein 60 is required for blastema formation and maintenance during regeneration. Proceedings of the National Academy of Sciences of the United States of America. 102: 14599-604. PMID 16204379 DOI: 10.1073/Pnas.0507408102  0.402
2005 Engel FB, Schebesta M, Duong MT, Lu G, Ren S, Madwed JB, Jiang H, Wang Y, Keating MT. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes & Development. 19: 1175-87. PMID 15870258 DOI: 10.1101/Gad.1306705  0.344
2005 Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC, Keating MT. Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations. Proceedings of the National Academy of Sciences of the United States of America. 102: 8089-96; discussion . PMID 15863612 DOI: 10.1073/Pnas.0502506102  0.373
2004 Ackerman MJ, Splawski I, Makielski JC, Tester DJ, Will ML, Timothy KW, Keating MT, Jones G, Chadha M, Burrow CR, Stephens JC, Xu C, Judson R, Curran ME. Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 1: 600-7. PMID 15851227 DOI: 10.1016/J.Hrthm.2004.07.013  0.377
2004 Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Molecular Cell. 16: 867-80. PMID 15610731 DOI: 10.1016/J.Molcel.2004.11.039  0.324
2004 Zhang L, Vincent GM, Baralle M, Baralle FE, Anson BD, Benson DW, Whiting B, Timothy KW, Carlquist J, January CT, Keating MT, Splawski I. An intronic mutation causes long QT syndrome. Journal of the American College of Cardiology. 44: 1283-91. PMID 15364333 DOI: 10.1016/J.Jacc.2004.06.045  0.345
2004 Keating MT. Genetic approaches to disease and regeneration. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 359: 795-8. PMID 15293807 DOI: 10.1098/Rstb.2004.1469  0.33
2004 Poss KD, Nechiporuk A, Stringer KF, Lee C, Keating MT. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes & Development. 18: 1527-32. PMID 15231734 DOI: 10.1101/Gad.1182604  0.721
2004 Mohler PJ, Splawski I, Napolitano C, Bottelli G, Sharpe L, Timothy K, Priori SG, Keating MT, Bennett V. A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proceedings of the National Academy of Sciences of the United States of America. 101: 9137-42. PMID 15178757 DOI: 10.1073/Pnas.0402546101  0.347
2003 Zareba W, Moss AJ, Sheu G, Kaufman ES, Priori S, Vincent GM, Towbin JA, Benhorin J, Schwartz PJ, Napolitano C, Hall WJ, Keating MT, Qi M, Robinson J, Andrews ML, et al. Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome. Journal of Cardiovascular Electrophysiology. 14: 1149-53. PMID 14678125 DOI: 10.1046/J.1540-8167.2003.03177.X  0.367
2003 Nechiporuk A, Poss KD, Johnson SL, Keating MT. Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. Developmental Biology. 258: 291-306. PMID 12798289 DOI: 10.1016/S0012-1606(03)00129-5  0.737
2003 Poss KD, Keating MT, Nechiporuk A. Tales of regeneration in zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 226: 202-10. PMID 12557199 DOI: 10.1002/Dvdy.10220  0.716
2002 Poss KD, Wilson LG, Keating MT. Heart regeneration in zebrafish. Science (New York, N.Y.). 298: 2188-90. PMID 12481136 DOI: 10.1126/Science.1077857  0.61
2002 Poss KD, Nechiporuk A, Hillam AM, Johnson SL, Keating MT. Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development (Cambridge, England). 129: 5141-9. PMID 12399306  0.735
2002 Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (New York, N.Y.). 297: 1333-6. PMID 12193783 DOI: 10.1126/Science.1073569  0.332
2002 Nechiporuk A, Keating MT. A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration. Development (Cambridge, England). 129: 2607-17. PMID 12015289  0.627
2002 Moss AJ, Zareba W, Kaufman ES, Gartman E, Peterson DR, Benhorin J, Towbin JA, Keating MT, Priori SG, Schwartz PJ, Vincent GM, Robinson JL, Andrews ML, Feng C, Hall WJ, et al. Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel. Circulation. 105: 794-9. PMID 11854117 DOI: 10.1161/Hc0702.105124  0.375
2002 Olson TM, Illenberger S, Kishimoto NY, Huttelmaier S, Keating MT, Jockusch BM. Metavinculin mutations alter actin interaction in dilated cardiomyopathy. Circulation. 105: 431-7. PMID 11815424 DOI: 10.1161/Hc0402.102930  0.377
2001 McGann CJ, Odelberg SJ, Keating MT. Mammalian myotube dedifferentiation induced by newt regeneration extract. Proceedings of the National Academy of Sciences of the United States of America. 98: 13699-704. PMID 11717431 DOI: 10.1073/Pnas.221297398  0.376
2001 Huang FD, Chen J, Lin M, Keating MT, Sanguinetti MC. Long-QT syndrome-associated missense mutations in the pore helix of the HERG potassium channel. Circulation. 104: 1071-5. PMID 11524404 DOI: 10.1161/Hc3501.093815  0.395
2001 Schwartz PJ, Priori SG, Spazzolini C, Moss AJ, Vincent GM, Napolitano C, Denjoy I, Guicheney P, Breithardt G, Keating MT, Towbin JA, Beggs AH, Brink P, Wilde AA, Toivonen L, et al. Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias. Circulation. 103: 89-95. PMID 11136691 DOI: 10.1161/01.Cir.103.1.89  0.345
2001 Nechiporuk T, Urness LD, Keating MT. ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily. The Journal of Biological Chemistry. 276: 4150-7. PMID 11050079 DOI: 10.1074/Jbc.M004814200  0.694
2000 Odelberg SJ, Kollhoff A, Keating MT. Dedifferentiation of mammalian myotubes induced by msx1. Cell. 103: 1099-109. PMID 11163185 DOI: 10.1016/S0092-8674(00)00212-9  0.321
2000 Poss KD, Shen J, Keating MT. Induction of lef1 during zebrafish fin regeneration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 219: 282-6. PMID 11002347 DOI: 10.1002/1097-0177(2000)9999:9999<::Aid-Dvdy1045>3.3.Co;2-3  0.601
2000 Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, Moss AJ, Schwartz PJ, Towbin JA, Vincent GM, Keating MT. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation. 102: 1178-85. PMID 10973849 DOI: 10.1161/01.Cir.102.10.1178  0.36
2000 Poss KD, Shen J, Nechiporuk A, McMahon G, Thisse B, Thisse C, Keating MT. Roles for Fgf signaling during zebrafish fin regeneration. Developmental Biology. 222: 347-58. PMID 10837124 DOI: 10.1006/Dbio.2000.9722  0.722
1999 Nechiporuk A, Finney JE, Keating MT, Johnson SL. Assessment of polymorphism in zebrafish mapping strains. Genome Research. 9: 1231-8. PMID 10613846 DOI: 10.1101/Gr.9.12.1231  0.603
1999 Franqueza L, Lin M, Shen J, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. The Journal of Biological Chemistry. 274: 21063-70. PMID 10409658 DOI: 10.1074/Jbc.274.30.21063  0.37
1999 Wang Z, Tristani-Firouzi M, Xu Q, Lin M, Keating MT, Sanguinetti MC. Functional effects of mutations in KvLQT1 that cause long QT syndrome. Journal of Cardiovascular Electrophysiology. 10: 817-26. PMID 10376919 DOI: 10.1111/J.1540-8167.1999.Tb00262.X  0.394
1999 Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 97: 175-87. PMID 10219239 DOI: 10.1016/S0092-8674(00)80728-X  0.359
1999 Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. The Journal of Biological Chemistry. 274: 10113-8. PMID 10187793 DOI: 10.1074/Jbc.274.15.10113  0.377
1999 Morris CA, Mervis CB, Robinson BF, Keating MT, Lu X, Meng X, Spallone P, Dennis TR, Stock AD. Long deletions of the Williams syndrome region on chromosome 7 result in more severe mental retardation Genetics in Medicine. 1: 59-59. DOI: 10.1097/00125817-199901000-00071  0.316
1998 Meng X, Lu X, Li Z, Green ED, Massa H, Trask BJ, Morris CA, Keating MT. Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes. Human Genetics. 103: 590-9. PMID 9860302 DOI: 10.1007/S004390050874  0.36
1998 Lu X, Meng X, Morris CA, Keating MT. A novel human gene, WSTF, is deleted in Williams syndrome. Genomics. 54: 241-9. PMID 9828126 DOI: 10.1006/Geno.1998.5578  0.381
1998 Meng X, Lu X, Morris CA, Keating MT. A novel human gene FKBP6 is deleted in Williams syndrome. Genomics. 52: 130-7. PMID 9782077 DOI: 10.1006/Geno.1998.5412  0.37
1998 Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Robinson JL, Priori SG, Benhorin J, Locati EH, Towbin JA, Keating MT, Lehmann MH, Hall WJ. Influence of genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. The New England Journal of Medicine. 339: 960-5. PMID 9753711 DOI: 10.1056/Nejm199810013391404  0.388
1998 Splawski I, Shen J, Timothy KW, Vincent GM, Lehmann MH, Keating MT. Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1. Genomics. 51: 86-97. PMID 9693036 DOI: 10.1006/Geno.1998.5361  0.395
1998 Olson TM, Michels VV, Thibodeau SN, Tai YS, Keating MT. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science (New York, N.Y.). 280: 750-2. PMID 9563954 DOI: 10.1126/Science.280.5364.750  0.355
1998 Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, ... Keating MT, et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 392: 293-6. PMID 9521325 DOI: 10.1038/32675  0.396
1997 Olson TM, Keating MT. Defining the molecular genetic basis of idiopathic dilated cardiomyopathy. Trends in Cardiovascular Medicine. 7: 60-3. PMID 21235865 DOI: 10.1016/S1050-1738(96)00139-9  0.372
1997 Keating MT. On the trail of genetic culprits in Williams syndrome. Cardiovascular Research. 36: 134-7. PMID 9463625 DOI: 10.1016/S0008-6363(97)00027-8  0.393
1997 Splawski I, Tristani-Firouzi M, Lehmann MH, Sanguinetti MC, Keating MT. Mutations in the hminK gene cause long QT syndrome and suppress IKs function. Nature Genetics. 17: 338-40. PMID 9354802 DOI: 10.1038/Ng1197-338  0.357
1997 Qian N, Frank D, O'Keefe D, Dao D, Zhao L, Yuan L, Wang Q, Keating M, Walsh C, Tycko B. The IPL gene on chromosome 11p15.5 is imprinted in humans and mice and is similar to TDAG51, implicated in Fas expression and apoptosis. Human Molecular Genetics. 6: 2021-9. PMID 9328465 DOI: 10.1093/Hmg/6.12.2021  0.352
1997 Li DY, Toland AE, Boak BB, Atkinson DL, Ensing GJ, Morris CA, Keating MT. Elastin point mutations cause an obstructive vascular disease, supravalvular aortic stenosis. Human Molecular Genetics. 6: 1021-8. PMID 9215670 DOI: 10.1093/Hmg/6.7.1021  0.35
1997 Orias M, Bray-Ward P, Curran ME, Keating MT, Desir GV. Genomic localization of the human gene for KCNA10, a cGMP-activated K channel. Genomics. 42: 33-7. PMID 9177773 DOI: 10.1006/Geno.1997.4712  0.335
1997 Sanguinetti MC, Keating MT. Role of delayed rectifier potassium channels in cardiac repolarization and arrhythmias News in Physiological Sciences. 12: 152-157. DOI: 10.1152/Physiologyonline.1997.12.4.152  0.3
1996 Keating MT, Sanguinetti MC. Pathophysiology of ion channel mutations. Current Opinion in Genetics & Development. 6: 326-33. PMID 8791523 DOI: 10.1016/S0959-437X(96)80010-4  0.311
1996 Sanguinetti MC, Curran ME, Spector PS, Keating MT. Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proceedings of the National Academy of Sciences of the United States of America. 93: 2208-12. PMID 8700910 DOI: 10.1073/Pnas.93.5.2208  0.396
1996 Frangiskakis JM, Ewart AK, Morris CA, Mervis CB, Bertrand J, Robinson BF, Klein BP, Ensing GJ, Everett LA, Green ED, Pröschel C, Gutowski NJ, Noble M, Atkinson DL, Odelberg SJ, ... Keating MT, et al. LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition. Cell. 86: 59-69. PMID 8689688 DOI: 10.1016/S0092-8674(00)80077-X  0.302
1996 Wang Q, Li Z, Shen J, Keating MT. Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics. 34: 9-16. PMID 8661019 DOI: 10.1006/Geno.1996.0236  0.385
1996 Dumaine R, Wang Q, Keating MT, Hartmann HA, Schwartz PJ, Brown AM, Kirsch GE. Multiple mechanisms of Na+ channel--linked long-QT syndrome. Circulation Research. 78: 916-24. PMID 8620612 DOI: 10.1161/01.Res.78.5.916  0.391
1996 Spector PS, Curran ME, Keating MT, Sanguinetti MC. Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides. Circulation Research. 78: 499-503. PMID 8593709 DOI: 10.1161/01.Res.78.3.499  0.305
1996 Keating MT. The long QT syndrome. A review of recent molecular genetic and physiologic discoveries. Medicine. 75: 1-5. PMID 8569466 DOI: 10.1097/00005792-199601000-00001  0.346
1996 Olson TM, Keating MT. Mapping a cardiomyopathy locus to chromosome 3p22-p25. The Journal of Clinical Investigation. 97: 528-32. PMID 8567977 DOI: 10.1172/Jci118445  0.36
1996 Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, VanRaay TJ, Shen J, Timothy KW, Vincent GM, de Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, ... ... Keating MT, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nature Genetics. 12: 17-23. PMID 8528244 DOI: 10.1038/Ng0196-17  0.418
1996 Priori SG, Napolitano C, Locati EH, Cantù F, Stramba-Badiale M, Keating MT, Towbin JA, Colatsky TJ, Chen LSK, Schwartz PJ. Long QT syndrome patients genetically linked to defective genes on chromosomes 11, 7 and 3 present differential response to changes in heart rate Journal of the American College of Cardiology. 27: 171-172. DOI: 10.1016/S0735-1097(96)81534-8  0.347
1995 Wang Q, Shen J, Li Z, Timothy K, Vincent GM, Priori SG, Schwartz PJ, Keating MT. Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Human Molecular Genetics. 4: 1603-7. PMID 8541846 DOI: 10.1093/Hmg/4.9.1603  0.392
1995 Schwartz PJ, Priori SG, Locati EH, Napolitano C, Cantù F, Towbin JA, Keating MT, Hammoude H, Brown AM, Chen LS. Long QT syndrome patients with mutations of the SCN5A and HERG genes have differential responses to Na+ channel blockade and to increases in heart rate. Implications for gene-specific therapy. Circulation. 92: 3381-6. PMID 8521555 DOI: 10.1161/01.Cir.92.12.3381  0.334
1995 Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell. 80: 805-11. PMID 7889574 DOI: 10.1016/0092-8674(95)90359-3  0.412
1995 Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell. 80: 795-803. PMID 7889573 DOI: 10.1016/0092-8674(95)90358-5  0.422
1995 Landes GM, Curran ME, Keating MT. Molecular characterization and refined genomic localization of three human potassium ion channel genes. Cytogenetics and Cell Genetics. 70: 280-4. PMID 7789190 DOI: 10.1159/000134052  0.305
1995 Keating MT. Genetic approaches to cardiovascular disease. Supravalvular aortic stenosis, Williams syndrome, and long-QT syndrome. Circulation. 92: 142-7. PMID 7788908 DOI: 10.1161/01.Cir.92.1.142  0.417
1995 Sanguinetti MC, Jiang C, Curran ME, Keating MT. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel. Cell. 81: 299-307. PMID 7736582 DOI: 10.1016/0092-8674(95)90340-2  0.351
1994 Keating M. Elastin and vascular disease. Trends in Cardiovascular Medicine. 4: 165-169. PMID 21244882 DOI: 10.1016/1050-1738(94)90053-1  0.327
1994 Ewart AK, Jin W, Atkinson D, Morris CA, Keating MT. Supravalvular aortic stenosis associated with a deletion disrupting the elastin gene. The Journal of Clinical Investigation. 93: 1071-7. PMID 8132745 DOI: 10.1172/Jci117057  0.38
1994 Jiang C, Atkinson D, Towbin JA, Splawski I, Lehmann MH, Li H, Timothy K, Taggart RT, Schwartz PJ, Vincent GM, Moss AJ, Keating MT. Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity Nature Genetics. 8: 141-147. PMID 7842012 DOI: 10.1038/Ng1094-141  0.358
1993 Ewart AK, Morris CA, Ensing GJ, Loker J, Moore C, Leppert M, Keating M. A human vascular disorder, supravalvular aortic stenosis, maps to chromosome 7. Proceedings of the National Academy of Sciences of the United States of America. 90: 3226-3230. PMID 8475063 DOI: 10.1073/Pnas.90.8.3226  0.33
1993 Curran M, Atkinson D, Timothy K, Vincent GM, Moss AJ, Leppert M, Keating M. Locus heterogeneity of autosomal dominant long QT syndrome. Journal of Clinical Investigation. 92: 799-803. PMID 8102381 DOI: 10.1172/Jci116653  0.361
1993 Curran ME, Atkinson DL, Ewart AK, Morris CA, Leppert MF, Keating MT. The elastin gene is disrupted by a translocation associated with supravalvular aortic stenosis. Cell. 73: 159-68. PMID 8096434 DOI: 10.1016/0092-8674(93)90168-P  0.336
1992 Vincent GM, Timothy KW, Leppert M, Keating M. The Spectrum of Symptoms and QT Intervals in Carriers of the Gene for the Long-QT Syndrome The New England Journal of Medicine. 327: 846-852. PMID 1508244 DOI: 10.1056/Nejm199209173271204  0.341
1992 Keating M. Linkage analysis and long QT syndrome. Using genetics to study cardiovascular disease. Circulation. 85: 1973-1986. PMID 1350520 DOI: 10.1161/01.Cir.85.6.1973  0.351
1992 Curran ME, Landes GM, Keating MT. Molecular cloning, characterization, and genomic localization of a human potassium channel gene. Genomics. 12: 729-37. PMID 1349297 DOI: 10.1016/0888-7543(92)90302-9  0.329
1991 Keating M, Atkinson D, Dunn C, Timothy K, Vincent G, Leppert M. Linkage of a cardiac arrhythmia, the long QT syndrome, and the Harvey ras-1 gene Science. 252: 704-706. PMID 1673802 DOI: 10.1126/Science.1673802  0.312
1989 Coughlin SR, Keating MT. The platelet-derived growth factor system. Cancer Treatment and Research. 47: 169-76. PMID 2576996 DOI: 10.1007/978-1-4613-1599-5_7  0.312
1987 Williams LT, Escobedo JA, Keating MT, Coughlin SR. The stimulation of paracrine and autocrine mitogenic pathways by the platelet-derived growth factor receptor. Journal of Cellular Physiology. Supplement. 27-30. PMID 2824531 DOI: 10.1002/Jcp.1041330406  0.303
Low-probability matches (unlikely to be authored by this person)
2003 Karnik SK, Brooke BS, Bayes-Genis A, Sorensen L, Wythe JD, Schwartz RS, Keating MT, Li DY. A critical role for elastin signaling in vascular morphogenesis and disease. Development (Cambridge, England). 130: 411-23. PMID 12466207 DOI: 10.1242/Dev.00223  0.299
2005 Bloise R, Timothy KW, Napolitano C, Splawski I, Schwartz PJ, Keating MT, Priori SG. Phenotypic characterization of Timothy syndrome - a complex cardiac and multisystem disorder Heart Rhythm. 2: S44-S45. DOI: 10.1016/J.Hrthm.2005.02.146  0.298
2004 Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC, Keating MT. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell. 119: 19-31. PMID 15454078 DOI: 10.1016/J.Cell.2004.09.011  0.297
1996 Keating MT, Sanguinetti MC. Molecular genetic insights into cardiovascular disease. Science (New York, N.Y.). 272: 681-5. PMID 8614827 DOI: 10.1126/Science.272.5262.681  0.297
1998 Giuli L, Zhang L, Timothy K, Fox J, Handrahan D, Moss A, Zareba W, Schwartz P, Lehmann M, Keating M, Towbin J, Vincent G. Long QT genotype can be identified by ECG phenotype Journal of the American College of Cardiology. 31: 192. DOI: 10.1016/S0735-1097(98)81475-7  0.295
1995 Marks ML, Whisler SL, Clericuzio C, Keating M. A new form of long QT syndrome associated with syndactyly Journal of the American College of Cardiology. 25: 59-64. PMID 7798527 DOI: 10.1016/0735-1097(94)00318-K  0.294
1997 Zou A, Curran ME, Keating MT, Sanguinetti MC. Single HERG delayed rectifier K+ channels expressed in Xenopus oocytes. The American Journal of Physiology. 272: H1309-14. PMID 9087606 DOI: 10.1152/Ajpheart.1997.272.3.H1309  0.29
1995 Keating MT. Molecular genetics of long QT syndrome. Society of General Physiologists Series. 50: 53-60. PMID 7676324  0.287
1998 Zareba W, Moss A, Robinson J, Schwart P, Vincent G, Priori S, Benhorin J, Locati E, Towbin J, Keating M, Lehmann M, Hall W, Napolitano C, Andrews M. Cardiac events in genotyped long QT syndrome patients Journal of the American College of Cardiology. 31: 349. DOI: 10.1016/S0735-1097(98)82157-8  0.287
1998 Li DY, Faury G, Taylor DG, Davis EC, Boyle WA, Mecham RP, Stenzel P, Boak B, Keating MT. Novel arterial pathology in mice and humans hemizygous for elastin. The Journal of Clinical Investigation. 102: 1783-7. PMID 9819363 DOI: 10.1172/Jci4487  0.281
1996 Compton SJ, Lux RL, Ramsey MR, Strelich KR, Sanguinetti MC, Green LS, Keating MT, Mason JW. Genetically defined therapy of inherited long-QT syndrome. Correction of abnormal repolarization by potassium. Circulation. 94: 1018-22. PMID 8790040 DOI: 10.1161/01.Cir.94.5.1018  0.279
2006 Stevenson TJ, Vinarsky V, Atkinson DL, Keating MT, Odelberg SJ. Tissue inhibitor of metalloproteinase 1 regulates matrix metalloproteinase activity during newt limb regeneration. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 235: 606-16. PMID 16372340 DOI: 10.1002/Dvdy.20654  0.271
1996 Spector PS, Curran ME, Zou A, Keating MT, Sanguinetti MC. Fast inactivation causes rectification of the IKr channel. The Journal of General Physiology. 107: 611-9. PMID 8740374 DOI: 10.1085/Jgp.107.5.611  0.269
1997 Lehmann MH, Timothy KW, Frankovich D, Fromm BS, Keating M, Locati EH, Taggart RT, Towbin JA, Moss AJ, Schwartz PJ, Vincent GM. Age-gender influence on the rate-corrected QT interval and the QT-heart rate relation in families with genotypically characterized long QT syndrome. Journal of the American College of Cardiology. 29: 93-9. PMID 8996300 DOI: 10.1016/S0735-1097(96)00454-8  0.265
1995 Marks ML, Trippel DL, Keating MT. Long QT syndrome associated with syndactyly identified in females. The American Journal of Cardiology. 76: 744-5. PMID 7572644 DOI: 10.1016/S0002-9149(99)80216-1  0.264
1988 Keating MT, Williams LT. Autocrine stimulation of intracellular PDGF receptors in v-sis-transformed cells. Science (New York, N.Y.). 239: 914-6. PMID 2829358 DOI: 10.1126/Science.2829358  0.261
2004 Westenskow P, Splawski I, Timothy KW, Keating MT, Sanguinetti MC. Compound mutations: a common cause of severe long-QT syndrome. Circulation. 109: 1834-41. PMID 15051636 DOI: 10.1161/01.Cir.0000125524.34234.13  0.26
2001 Keating MT, Sanguinetti MC. Molecular and cellular mechanisms of cardiac arrhythmias. Cell. 104: 569-80. PMID 11239413 DOI: 10.1016/S0092-8674(01)00243-4  0.257
2005 Vinarsky V, Atkinson DL, Stevenson TJ, Keating MT, Odelberg SJ. Normal newt limb regeneration requires matrix metalloproteinase function. Developmental Biology. 279: 86-98. PMID 15708560 DOI: 10.1016/J.Ydbio.2004.12.003  0.255
2000 Wendel DP, Taylor DG, Albertine KH, Keating MT, Li DY. Impaired distal airway development in mice lacking elastin. American Journal of Respiratory Cell and Molecular Biology. 23: 320-6. PMID 10970822 DOI: 10.1165/Ajrcmb.23.3.3906  0.254
1997 Splawski I, Timothy KW, Vincent GM, Atkinson DL, Keating MT. George M. Cober Lecturer: Mark T. Keating. Molecular basis of the long-QT syndrome associated with deafness. Proceedings of the Association of American Physicians. 109: 504-11. PMID 9285950  0.251
1993 Ewart AK, Morris CA, Atkinson D, Jin W, Sternes K, Spallone P, Stock AD, Leppert M, Keating MT. Hemizygosity at the elastin locus in a developmental disorder, Williams syndrome. Nature Genetics. 5: 11-6. PMID 7693128 DOI: 10.1038/ng0993-11  0.25
1998 Li DY, Brooke B, Davis EC, Mecham RP, Sorensen LK, Boak BB, Eichwald E, Keating MT. Elastin is an essential determinant of arterial morphogenesis. Nature. 393: 276-80. PMID 9607766 DOI: 10.1038/30522  0.249
1996 Zareba W, Narins CR, Moss AJ, Benhorin J, Locati EH, Priori SG, Schwartz PJ, Vincent G, Lehmann M, Jackson Hall W, Robinson JL, Zhang L, Towbin JA, Keating MT, MacCluer JW, et al. Dispersion of repolarization and the genotype of long QT syndrome Journal of the American College of Cardiology. 27: 20. DOI: 10.1016/S0735-1097(96)80265-8  0.247
1987 KEATING M, WILLIAMS L. Platelet-derived growth factor receptor biosynthesis and degradation Journal of Molecular and Cellular Cardiology. 19: S3-S3. DOI: 10.1016/S0022-2828(87)80632-6  0.238
2004 Wang Q, Chen S, Chen Q, Wan X, Shen J, Hoeltge GA, Timur AA, Keating MT, Kirsch GE. The common SCN5A mutation R1193Q causes LQTS-type electrophysiological alterations of the cardiac sodium channel. Journal of Medical Genetics. 41: e66. PMID 15121794  0.232
2007 Kühn B, del Monte F, Hajjar RJ, Chang YS, Lebeche D, Arab S, Keating MT. Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair. Nature Medicine. 13: 962-9. PMID 17632525 DOI: 10.1038/nm1619  0.218
1994 Curran M, Keating M. A polymorphic dinucleotide repeat in the second intron of HUMCLC Human Molecular Genetics. 3: 2264-2264. PMID 7881436 DOI: 10.1093/Hmg/3.12.2264-A  0.214
1999 Faury G, Maher GM, Li DY, Keating MT, Mecham RP, Boyle WA. Relation between outer and luminal diameter in cannulated arteries. The American Journal of Physiology. 277: H1745-53. PMID 10564127 DOI: 10.1152/Ajpheart.1999.277.5.H1745  0.208
2003 Morris CA, Mervis CB, Hobart HH, Gregg RG, Bertrand J, Ensing GJ, Sommer A, Moore CA, Hopkin RJ, Spallone PA, Keating MT, Osborne L, Kimberley KW, Stock AD. GTF2I hemizygosity implicated in mental retardation in Williams syndrome: genotype-phenotype analysis of five families with deletions in the Williams syndrome region. American Journal of Medical Genetics. Part A. 123: 45-59. PMID 14556246 DOI: 10.1002/Ajmg.A.20496  0.201
1996 Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL, Keating MT. Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature. 384: 80-3. PMID 8900283 DOI: 10.1038/384080a0  0.2
2006 Engel FB, Schebesta M, Keating MT. Anillin localization defect in cardiomyocyte binucleation. Journal of Molecular and Cellular Cardiology. 41: 601-12. PMID 16889791 DOI: 10.1016/j.yjmcc.2006.06.012  0.195
2016 Fong AH, Romero-López M, Heylman CM, Keating M, Tran D, Sobrino A, Tran AQ, Pham HH, Fimbres C, Gershon PD, Botvinick EL, George SC, Hughes CC. Three-dimensional adult cardiac extracellular matrix promotes maturation of human induced pluripotent stem cell-derived cardiomyocytes. Tissue Engineering. Part A. PMID 27392582 DOI: 10.1089/Ten.Tea.2016.0027  0.189
1998 Zhang L, Timothy K, Fox J, Lehmann M, Meyer K, Moss A, Robinson J, Schwartz P, Keating M, Towbin J, Vincent G. Prevalence of the bifid T waves in genotyped LQTS children Journal of the American College of Cardiology. 31: 193. DOI: 10.1016/S0735-1097(98)81477-0  0.185
2000 Zhang L, Timothy KW, Vincent GM, Lehmann MH, Fox J, Giuli LC, Shen J, Splawski I, Priori SG, Compton SJ, Yanowitz F, Benhorin J, Moss AJ, Schwartz PJ, Robinson JL, ... ... Keating MT, et al. Spectrum of ST-T-wave patterns and repolarization parameters in congenital long-QT syndrome: ECG findings identify genotypes. Circulation. 102: 2849-55. PMID 11104743 DOI: 10.1161/01.Cir.102.23.2849  0.181
2016 Arulmoli J, Wright HJ, Phan DT, Sheth U, Que RA, Botten GA, Keating M, Botvinick EL, Pathak MM, Zarembinski TI, Yanni DS, Razorenova OV, Hughes CC, Flanagan LA. Combination scaffolds of salmon fibrin, hyaluronic acid, and laminin for human neural stem cell and vascular tissue engineering. Acta Biomaterialia. PMID 27475528 DOI: 10.1016/J.Actbio.2016.07.043  0.178
2007 Keating M. Mending broken hearts: the future of drug-based cardiac regeneration. Future Cardiology. 3: 493-5. PMID 19804302 DOI: 10.2217/14796678.3.5.493  0.176
1990 Harsh GR, Keating MT, Escobedo JA, Williams LT. Platelet derived growth factor (PDGF) autocrine components in human tumor cell lines. Journal of Neuro-Oncology. 8: 1-12. PMID 2156959 DOI: 10.1007/Bf00182081  0.172
1995 Nickerson E, Greenberg F, Keating MT, McCaskill C, Shaffer LG. Deletions of the elastin gene at 7q11.23 occur in approximately 90% of patients with Williams syndrome. American Journal of Human Genetics. 56: 1156-61. PMID 7726172  0.17
2004 Glatter KA, Wang Q, Keating M, Chen S, Chiamvimonvat N, Scheinman MM. Effectiveness of sotalol treatment in symptomatic Brugada syndrome American Journal of Cardiology. 93: 1320-1322. PMID 15135718 DOI: 10.1016/J.Amjcard.2004.02.023  0.167
2004 Goldstein SAN, Keating MT, Sanguinetti MC. Cardiac Arrhythmias: Inherited Molecular Mechanisms Molecular Basis of Cardiovascular Disease: a Companion to Braunwald's Heart Disease. 336-348. DOI: 10.1016/B978-0-7216-9428-3.50024-X  0.163
1988 Escobedo JA, Keating MT, Ives HE, Williams LT. Platelet-derived growth factor receptors expressed by cDNA transfection couple to a diverse group of cellular responses associated with cell proliferation. The Journal of Biological Chemistry. 263: 1482-7. PMID 2826480  0.154
2018 Juliar BA, Keating MT, Kong YP, Botvinick EL, Putnam AJ. Sprouting angiogenesis induces significant mechanical heterogeneities and ECM stiffening across length scales in fibrin hydrogels. Biomaterials. 162: 99-108. PMID 29438884 DOI: 10.1016/J.Biomaterials.2018.02.012  0.15
1997 Keating MT, Curran ME, Wang Q. Long QT syndrome genes Biotechnology Advances. 15: 724.  0.15
2007 Keating M. Mending broken hearts: The future of drug-based cardiac regeneration Future Cardiology. 3: 493-495. DOI: 10.2217/14796678.3.5.493  0.137
1977 Keating MT, Bonner JT. Negative chemotaxis in cellular slime molds. Journal of Bacteriology. 130: 144-7. PMID 558186 DOI: 10.1128/Jb.130.1.144-147.1977  0.137
2016 Romero-López M, Trinh AL, Sobrino A, Hatch MM, Keating MT, Fimbres C, Lewis DE, Gershon PD, Botvinick EL, Digman M, Lowengrub JS, Hughes CC. Recapitulating the human tumor microenvironment: Colon tumor-derived extracellular matrix promotes angiogenesis and tumor cell growth. Biomaterials. 116: 118-129. PMID 27914984 DOI: 10.1016/J.Biomaterials.2016.11.034  0.125
1997 Bitner-Glindzicz M, Tyson J, Jamieson R, Keating MT. Molecular basis of the long-QT syndrome [5] (multiple letters) New England Journal of Medicine. 337: 1011-1013. PMID 9312674 DOI: 10.1056/NEJM199710023371416  0.12
2019 Keating M, Lim M, Hu Q, Botvinick E. Selective Stiffening of Fibrin Hydrogels with Micron Resolution Via Photocrosslinking. Acta Biomaterialia. PMID 30660778 DOI: 10.1016/J.Actbio.2019.01.034  0.118
1997 Splawski I, Timothy KW, Vincent GM, Atkinson DL, Keating MT. Molecular basis of the long-QT syndrome associated with deafness. The New England Journal of Medicine. 336: 1562-7. PMID 9164812 DOI: 10.1056/NEJM199705293362204  0.115
2021 Thrivikraman G, Jagiełło A, Lai VK, Johnson SL, Keating M, Nelson A, Schultz B, Wang CM, Levine AJ, Botvinick EL, Tranquillo RT. Cell contact guidance via sensing anisotropy of network mechanical resistance. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34266950 DOI: 10.1073/pnas.2024942118  0.113
2017 Gurlin RE, Keating MT, Li S, Lakey JR, de Feraudy S, Shergill BS, Botvinick EL. Vascularization and innervation of slits within polydimethylsiloxane sheets in the subcutaneous space of athymic nude mice. Journal of Tissue Engineering. 8: 2041731417691645. PMID 28228933 DOI: 10.1177/2041731417691645  0.111
2015 Kurup A, Ravindranath S, Tran T, Keating M, Gascard P, Valdevit L, Tlsty TD, Botvinick EL. Novel insights from 3D models: the pivotal role of physical symmetry in epithelial organization. Scientific Reports. 5: 15153. PMID 26472542 DOI: 10.1038/Srep15153  0.108
1989 Keating MT, Harryman CC, Williams LT. Platelet-derived growth factor receptor inducibility is acquired immediately after translation and does not require glycosylation. The Journal of Biological Chemistry. 264: 9129-32. PMID 2542300  0.105
2022 Brown KM, Nair JK, Janas MM, Anglero-Rodriguez YI, Dang LTH, Peng H, Theile CS, Castellanos-Rizaldos E, Brown C, Foster D, Kurz J, Allen J, Maganti R, Li J, Matsuda S, ... ... Keating M, et al. Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates. Nature Biotechnology. PMID 35654979 DOI: 10.1038/s41587-022-01334-x  0.103
1988 Williams LT, Escobedo JA, Keating MT, Coughlin SR. Signal transduction by the platelet-derived growth factor receptor. Cold Spring Harbor Symposia On Quantitative Biology. 53: 455-65. PMID 2855486 DOI: 10.1101/Sqb.1988.053.01.053  0.094
1988 Keating MT, Escobedo JA, Williams LT. Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation. The Journal of Biological Chemistry. 263: 12805-8. PMID 2843499  0.094
1988 Keating MT, Escobedo JA, Fantl WJ, Williams LT. Ligand activation causes a phosphorylation-dependent change in platelet-derived growth factor receptor conformation. Transactions of the Association of American Physicians. 101: 24-32. PMID 2480016  0.094
2019 Hsieh JY, Keating MT, Smith TD, Meli VS, Botvinick EL, Liu WF. Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation. Apl Bioengineering. 3: 016103. PMID 31069336 DOI: 10.1063/1.5067301  0.093
1993 Phromchotikul T, Browne DL, Curran ME, Keating MT, Litt M. Dinucleotide repeat polymorphism at the KCNA5 locus. Human Molecular Genetics. 2: 1512. PMID 8242092 DOI: 10.1093/hmg/2.9.1512-a  0.075
1987 Keating MT, Williams LT. Processing of the platelet-derived growth factor receptor. Biosynthetic and degradation studies using anti-receptor antibodies. The Journal of Biological Chemistry. 262: 7932-7. PMID 3034910  0.075
2015 Brown AC, Baker SR, Douglas AM, Keating M, Alvarez-Elizondo MB, Botvinick EL, Guthold M, Barker TH. Molecular interference of fibrin's divalent polymerization mechanism enables modulation of multiscale material properties. Biomaterials. 49: 27-36. PMID 25725552 DOI: 10.1016/J.Biomaterials.2015.01.010  0.06
1980 Garn SM, Keating MT. Effect of various prenatal determinants on size and growth through seven years Ecology of Food and Nutrition. 9: 109-112. DOI: 10.1080/03670244.1980.9990588  0.059
1999 Faury G, Maher GM, Li DY, Keating MT, Mecham RP, Boyle WA. Relation between outer and luminal diameter in cannulated arteries. American Journal of Physiology. Heart and Circulatory Physiology. 277: H1745-H1753. PMID 29591995 DOI: 10.1152/ajpheart.1999.277.5.H1745  0.056
2022 Nishimura JI, Ando K, Masuko M, Noji H, Ito Y, Mayer J, Griskevicius L, Bucher C, Müllershausen F, Gergely P, Rozenberg I, Schubart A, Chawla R, Rondeau JM, Roguska M, ... ... Keating MT, et al. Tesidolumab (LFG316) for treatment of C5-variant patients with paroxysmal nocturnal hemoglobinuria. Haematologica. PMID 35263983 DOI: 10.3324/haematol.2020.265868  0.05
1994 Wang Q, Keating MT. Isolation of P1 insert ends by direct sequencing. Biotechniques. 17: 282, 284. PMID 7980927  0.046
2022 Nguyen D, Lawrence MM, Berg H, Lyons MA, Shreim S, Keating MT, Weidling J, Botvinick EL. Transcutaneous Flexible Sensor for Photonic Detection of pH and Lactate. Acs Sensors. PMID 35175733 DOI: 10.1021/acssensors.1c01720  0.041
2021 Dror N, Weidling J, White S, Ortenzio F, Shreim S, Keating MT, Pham H, Radom-Aizik S, Botvinick E. Clinical evaluation of a novel subcutaneous lactate monitor. Journal of Clinical Monitoring and Computing. PMID 33837904 DOI: 10.1007/s10877-021-00685-1  0.037
1982 Lamb ME, Garn SM, Keating MT. Correlations between sociability and motor performance scores in 8-month-olds Infant Behavior and Development. 5: 97-101. DOI: 10.1016/S0163-6383(82)80019-2  0.024
1974 Boyle PH, Keating MT. Asymmetric hydrogenation of a carbon-nitrogen double bond in folic acid Journal of the Chemical Society, Chemical Communications. 375-376. DOI: 10.1039/C39740000375  0.012
1981 Garn SM, Keating MT, Falkner F. Hematological status and pregnancy outcomes. The American Journal of Clinical Nutrition. 34: 115-7. PMID 7446451  0.01
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