| Year |
Citation |
Score |
| 2022 |
Stoeger T, Grant RA, McQuattie-Pimentel AC, Anekalla KR, Liu SS, Tejedor-Navarro H, Singer BD, Abdala-Valencia H, Schwake M, Tetreault MP, Perlman H, Balch WE, Chandel NS, Ridge KM, Sznajder JI, ... Morimoto RI, et al. Aging is associated with a systemic length-associated transcriptome imbalance. Nature Aging. 2: 1191-1206. PMID 37118543 DOI: 10.1038/s43587-022-00317-6 |
0.651 |
|
| 2021 |
Lior C, Hodge F, De-Souza EA, Bourboulia D, Calderwood SK, David D, Allan Drummond D, Edkins A, Morimoto RI, Prahlad V, Rechavi O, Sistonen L, Wilson M, Wiseman RL, Zanetti M, et al. The 2021 FASEB Virtual Catalyst Conference on Extracellular and Organismal Proteostasis in Health and Disease, February 3-4, 2021. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21631. PMID 34046940 DOI: 10.1096/fj.202100566 |
0.741 |
|
| 2021 |
Sinnige T, Meisl G, Michaels TCT, Vendruscolo M, Knowles TPJ, Morimoto RI. Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in . Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33836595 DOI: 10.1073/pnas.2021888118 |
0.316 |
|
| 2020 |
Yamamoto YH, Kasai A, Omori H, Takino T, Sugihara M, Umemoto T, Hamasaki M, Hatta T, Natsume T, Morimoto RI, Arai R, Waguri S, Sato M, Sato K, Bar-Nun S, et al. ERdj8 governs the size of autophagosomes during the formation process. The Journal of Cell Biology. 219. PMID 32492081 DOI: 10.1083/Jcb.201903127 |
0.301 |
|
| 2020 |
Sinnige T, Yu A, Morimoto RI. Challenging Proteostasis: Role of the Chaperone Network to Control Aggregation-Prone Proteins in Human Disease. Advances in Experimental Medicine and Biology. 1243: 53-68. PMID 32297211 DOI: 10.1007/978-3-030-40204-4_4 |
0.514 |
|
| 2020 |
Sala AJ, Bott LC, Brielmann RM, Morimoto RI. Embryo integrity regulates maternal proteostasis and stress resilience. Genes & Development. PMID 32217667 DOI: 10.1101/Gad.335422.119 |
0.382 |
|
| 2020 |
Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP. Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 32067958 DOI: 10.1016/J.Jcf.2020.02.006 |
0.302 |
|
| 2019 |
Ciryam P, Antalek M, Cid F, Tartaglia GG, Dobson CM, Guettsches AK, Eggers B, Vorgerd M, Marcus K, Kley RA, Morimoto RI, Vendruscolo M, Weihl CC. A metastable subproteome underlies inclusion formation in muscle proteinopathies. Acta Neuropathologica Communications. 7: 197. PMID 31796104 DOI: 10.1186/S40478-019-0853-9 |
0.405 |
|
| 2019 |
Morimoto RI. Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease. Cold Spring Harbor Perspectives in Biology. PMID 30962274 DOI: 10.1101/Cshperspect.A034074 |
0.458 |
|
| 2019 |
Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, Morimoto RI. Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network. The Journal of Biological Chemistry. PMID 30936201 DOI: 10.1074/Jbc.Ra119.007527 |
0.535 |
|
| 2019 |
Grandjean JMD, Plate L, Morimoto RI, Bollong MJ, Powers ET, Wiseman RL. Deconvoluting Stress-Responsive Proteostasis Signaling Pathways for Pharmacologic Activation using Targeted RNA-sequencing. Acs Chemical Biology. PMID 30821953 DOI: 10.1021/Acschembio.9B00134 |
0.379 |
|
| 2018 |
Stoeger T, Gerlach M, Morimoto RI, Nunes Amaral LA. Large-scale investigation of the reasons why potentially important genes are ignored. Plos Biology. 16: e2006643. PMID 30226837 DOI: 10.1371/Journal.Pbio.2006643 |
0.663 |
|
| 2017 |
Labbadia J, Brielmann RM, Neto MF, Lin YF, Haynes CM, Morimoto RI. Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Cell Reports. 21: 1481-1494. PMID 29117555 DOI: 10.1016/J.Celrep.2017.10.038 |
0.813 |
|
| 2017 |
Kirstein J, Arnsburg K, Scior A, Szlachcic A, Guilbride DL, Morimoto RI, Bukau B, Nillegoda NB. In vivo properties of the disaggregase function of J-proteins and Hsc70 in Caenorhabditis elegans stress and aging. Aging Cell. PMID 29024389 DOI: 10.1111/Acel.12686 |
0.787 |
|
| 2017 |
Alves LGA, Winter PB, Ferreira LN, Brielmann RM, Morimoto RI, Amaral LAN. Long-range correlations and fractal dynamics in C. elegans: Changes with aging and stress. Physical Review. E. 96: 022417. PMID 28950588 DOI: 10.1103/Physreve.96.022417 |
0.341 |
|
| 2017 |
Li J, Labbadia J, Morimoto RI. Rethinking HSF1 in Stress, Development, and Organismal Health. Trends in Cell Biology. PMID 28890254 DOI: 10.1016/J.Tcb.2017.08.002 |
0.843 |
|
| 2017 |
Kundra R, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M. Protein homeostasis of a metastable subproteome associated with Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652376 DOI: 10.1073/Pnas.1618417114 |
0.414 |
|
| 2017 |
Sala AJ, Bott LC, Morimoto RI. Shaping proteostasis at the cellular, tissue, and organismal level. The Journal of Cell Biology. PMID 28400444 DOI: 10.1083/Jcb.201612111 |
0.381 |
|
| 2017 |
Ciryam P, Lambert-Smith IA, Bean DM, Freer R, Cid F, Tartaglia GG, Saunders DN, Wilson MR, Oliver SG, Morimoto RI, Dobson CM, Vendruscolo M, Favrin G, Yerbury JJ. Spinal motor neuron protein supersaturation patterns are associated with inclusion body formation in ALS. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396410 DOI: 10.1073/Pnas.1613854114 |
0.4 |
|
| 2017 |
Zhang Y, Benmohamed R, Zhang W, Kim J, Edgerly CK, Zhu Y, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS". Acs Medicinal Chemistry Letters. 8: 377. PMID 28337334 DOI: 10.1021/Acsmedchemlett.7B00070 |
0.309 |
|
| 2017 |
Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 168: 944. PMID 28235202 DOI: 10.1016/J.Cell.2016.12.041 |
0.316 |
|
| 2016 |
Li J, Chauve L, Phelps G, Brielmann RM, Morimoto RI. E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Genes & Development. PMID 27688402 DOI: 10.1101/Gad.283317.116 |
0.518 |
|
| 2016 |
Ciryam P, Kundra R, Freer R, Morimoto RI, Dobson CM, Vendruscolo M. A transcriptional signature of Alzheimer's disease is associated with a metastable subproteome at risk for aggregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27071083 DOI: 10.1073/Pnas.1516604113 |
0.421 |
|
| 2015 |
Teixeira-Castro A, Jalles A, Esteves S, Kang S, da Silva Santos L, Silva-Fernandes A, Neto MF, Brielmann RM, Bessa C, Duarte-Silva S, Miranda A, Oliveira S, Neves-Carvalho A, Bessa J, Summavielle T, ... ... Morimoto RI, et al. Serotonergic signalling suppresses ataxin 3 aggregation and neurotoxicity in animal models of Machado-Joseph disease. Brain : a Journal of Neurology. PMID 26373603 DOI: 10.1093/Brain/Awv262 |
0.317 |
|
| 2015 |
Nillegoda NB, Kirstein J, Szlachcic A, Berynskyy M, Stank A, Stengel F, Arnsburg K, Gao X, Scior A, Aebersold R, Guilbride DL, Wade RC, Morimoto RI, Mayer MP, Bukau B. Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation. Nature. 524: 247-51. PMID 26245380 DOI: 10.1038/Nature14884 |
0.775 |
|
| 2015 |
Kirstein J, Morito D, Kakihana T, Sugihara M, Minnen A, Hipp MS, Nussbaum-Krammer C, Kasturi P, Hartl FU, Nagata K, Morimoto RI. Proteotoxic stress and ageing triggers the loss of redox homeostasis across cellular compartments. The Embo Journal. 34: 2334-49. PMID 26228940 DOI: 10.15252/Embj.201591711 |
0.721 |
|
| 2015 |
Labbadia J, Morimoto RI. Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction. Molecular Cell. 59: 639-50. PMID 26212459 DOI: 10.1016/J.Molcel.2015.06.027 |
0.827 |
|
| 2015 |
Zhang Y, Zhao KT, Fox SG, Kim J, Kirsch DR, Ferrante RJ, Morimoto RI, Silverman RB. Tertiary amine pyrazolones and their salts as inhibitors of mutant superoxide dismutase 1-dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. PMID 26186011 DOI: 10.1021/Acs.Jmedchem.5B00561 |
0.333 |
|
| 2015 |
Brandvold KR, Morimoto RI. The Chemical Biology of Molecular Chaperones-Implications for Modulation of Proteostasis. Journal of Molecular Biology. 427: 2931-47. PMID 26003923 DOI: 10.1016/J.Jmb.2015.05.010 |
0.494 |
|
| 2015 |
Walther DM, Kasturi P, Zheng M, Pinkert S, Vecchi G, Ciryam P, Morimoto RI, Dobson CM, Vendruscolo M, Mann M, Hartl FU. Widespread Proteome Remodeling and Aggregation in Aging C. elegans. Cell. 161: 919-32. PMID 25957690 DOI: 10.1016/J.Cell.2015.03.032 |
0.472 |
|
| 2015 |
Labbadia J, Morimoto RI. The biology of proteostasis in aging and disease. Annual Review of Biochemistry. 84: 435-64. PMID 25784053 DOI: 10.1146/Annurev-Biochem-060614-033955 |
0.811 |
|
| 2015 |
Ciryam P, Kundra R, Morimoto RI, Dobson CM, Vendruscolo M. Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. Trends in Pharmacological Sciences. 36: 72-7. PMID 25636813 DOI: 10.1016/J.Tips.2014.12.004 |
0.452 |
|
| 2015 |
Nussbaum-Krammer CI, Neto MF, Brielmann RM, Pedersen JS, Morimoto RI. Investigating the spreading and toxicity of prion-like proteins using the metazoan model organism C. elegans. Journal of Visualized Experiments : Jove. 52321. PMID 25591151 DOI: 10.3791/52321 |
0.44 |
|
| 2015 |
Tatum MC, Ooi FK, Chikka MR, Chauve L, Martinez-Velazquez LA, Steinbusch HW, Morimoto RI, Prahlad V. Neuronal serotonin release triggers the heat shock response in C. elegans in the absence of temperature increase. Current Biology : Cb. 25: 163-74. PMID 25557666 DOI: 10.1016/J.Cub.2014.11.040 |
0.773 |
|
| 2014 |
Brehme M, Voisine C, Rolland T, Wachi S, Soper JH, Zhu Y, Orton K, Villella A, Garza D, Vidal M, Ge H, Morimoto RI. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Reports. 9: 1135-50. PMID 25437566 DOI: 10.1016/J.Celrep.2014.09.042 |
0.769 |
|
| 2014 |
Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 159: 709-13. PMID 25417146 DOI: 10.1016/J.Cell.2014.10.039 |
0.499 |
|
| 2014 |
Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE. Modulation of the maladaptive stress response to manage diseases of protein folding. Plos Biology. 12: e1001998. PMID 25406061 DOI: 10.1371/Journal.Pbio.1001998 |
0.48 |
|
| 2014 |
van Oosten-Hawle P, Morimoto RI. Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling. Genes & Development. 28: 1533-43. PMID 25030693 DOI: 10.1101/Gad.241125.114 |
0.443 |
|
| 2014 |
Trippier PC, Zhao KT, Fox SG, Schiefer IT, Benmohamed R, Moran J, Kirsch DR, Morimoto RI, Silverman RB. Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosis. Acs Chemical Neuroscience. 5: 823-9. PMID 25001311 DOI: 10.1021/Cn500147V |
0.427 |
|
| 2014 |
Shibata Y, Morimoto RI. How the nucleus copes with proteotoxic stress. Current Biology : Cb. 24: R463-74. PMID 24845679 DOI: 10.1016/J.Cub.2014.03.033 |
0.445 |
|
| 2014 |
Morimoto RI, Cuervo AM. Proteostasis and the aging proteome in health and disease. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 69: S33-8. PMID 24833584 DOI: 10.1093/Gerona/Glu049 |
0.444 |
|
| 2014 |
Yu A, Shibata Y, Shah B, Calamini B, Lo DC, Morimoto RI. Protein aggregation can inhibit clathrin-mediated endocytosis by chaperone competition. Proceedings of the National Academy of Sciences of the United States of America. 111: E1481-90. PMID 24706768 DOI: 10.1073/Pnas.1321811111 |
0.809 |
|
| 2014 |
Ryno LM, Genereux JC, Naito T, Morimoto RI, Powers ET, Shoulders MD, Wiseman RL. Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1. Acs Chemical Biology. 9: 1273-83. PMID 24689980 DOI: 10.1021/Cb500062N |
0.491 |
|
| 2014 |
Labbadia J, Morimoto RI. Proteostasis and longevity: when does aging really begin? F1000prime Reports. 6: 7. PMID 24592319 DOI: 10.12703/P6-7 |
0.789 |
|
| 2014 |
Kitamura A, Inada N, Kubota H, Matsumoto G, Kinjo M, Morimoto RI, Nagata K. Dysregulation of the proteasome increases the toxicity of ALS-linked mutant SOD1. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 19: 209-24. PMID 24450587 DOI: 10.1111/Gtc.12125 |
0.424 |
|
| 2014 |
Nussbaum-Krammer CI, Morimoto RI. Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases. Disease Models & Mechanisms. 7: 31-9. PMID 24396152 DOI: 10.1242/Dmm.013011 |
0.466 |
|
| 2014 |
Morimoto R. Creating a path from the heat shock response to therapeutics of protein-folding diseases: An interview with Rick Morimoto Dmm Disease Models and Mechanisms. 7: 5-8. PMID 24396148 DOI: 10.1242/Dmm.014753 |
0.5 |
|
| 2014 |
van Oosten-Hawle P, Morimoto RI. Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses. The Journal of Experimental Biology. 217: 129-36. PMID 24353212 DOI: 10.1242/Jeb.091249 |
0.392 |
|
| 2014 |
Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, O'Brien EP, Vendruscolo M. Proteome Metastability in Health, Aging, and Disease Biophysical Journal. 106: 59a. DOI: 10.1016/J.Bpj.2013.11.405 |
0.472 |
|
| 2014 |
Morimoto R. Cell Stress and Proteostasis Networks in Biology, Aging, and Disease Biophysical Journal. 106: 34a. DOI: 10.1016/J.Bpj.2013.11.259 |
0.485 |
|
| 2013 |
Ciryam P, Tartaglia GG, Morimoto RI, Dobson CM, Vendruscolo M. Widespread aggregation and neurodegenerative diseases are associated with supersaturated proteins. Cell Reports. 5: 781-90. PMID 24183671 DOI: 10.1016/J.Celrep.2013.09.043 |
0.475 |
|
| 2013 |
Gidalevitz T, Wang N, Deravaj T, Alexander-Floyd J, Morimoto RI. Natural genetic variation determines susceptibility to aggregation or toxicity in a C. elegans model for polyglutamine disease. Bmc Biology. 11: 100. PMID 24079614 DOI: 10.1186/1741-7007-11-100 |
0.769 |
|
| 2013 |
Silva MC, Amaral MD, Morimoto RI. Neuronal reprograming of protein homeostasis by calcium-dependent regulation of the heat shock response. Plos Genetics. 9: e1003711. PMID 24009518 DOI: 10.1371/Journal.Pgen.1003711 |
0.437 |
|
| 2013 |
Kirstein-Miles J, Morimoto RI. Ribosome-associated chaperones act as proteostasis sentinels. Cell Cycle (Georgetown, Tex.). 12: 2335-6. PMID 23856581 DOI: 10.4161/Cc.25703 |
0.474 |
|
| 2013 |
Bersuker K, Hipp MS, Calamini B, Morimoto RI, Kopito RR. Heat shock response activation exacerbates inclusion body formation in a cellular model of Huntington disease. The Journal of Biological Chemistry. 288: 23633-8. PMID 23839939 DOI: 10.1074/Jbc.C113.481945 |
0.814 |
|
| 2013 |
Labbadia J, Morimoto RI. Huntington's disease: underlying molecular mechanisms and emerging concepts. Trends in Biochemical Sciences. 38: 378-85. PMID 23768628 DOI: 10.1016/J.Tibs.2013.05.003 |
0.803 |
|
| 2013 |
van Oosten-Hawle P, Porter RS, Morimoto RI. Regulation of organismal proteostasis by transcellular chaperone signaling. Cell. 153: 1366-78. PMID 23746847 DOI: 10.1016/J.Cell.2013.05.015 |
0.428 |
|
| 2013 |
Guisbert E, Czyz DM, Richter K, McMullen PD, Morimoto RI. Identification of a tissue-selective heat shock response regulatory network. Plos Genetics. 9: e1003466. PMID 23637632 DOI: 10.1371/Journal.Pgen.1003466 |
0.836 |
|
| 2013 |
Kirstein-Miles J, Scior A, Deuerling E, Morimoto RI. The nascent polypeptide-associated complex is a key regulator of proteostasis. The Embo Journal. 32: 1451-68. PMID 23604074 DOI: 10.1038/Emboj.2013.87 |
0.523 |
|
| 2013 |
Nussbaum-Krammer CI, Park KW, Li L, Melki R, Morimoto RI. Spreading of a prion domain from cell-to-cell by vesicular transport in Caenorhabditis elegans. Plos Genetics. 9: e1003351. PMID 23555277 DOI: 10.1371/Journal.Pgen.1003351 |
0.421 |
|
| 2013 |
Zhang Y, Benmohamed R, Huang H, Chen T, Voisine C, Morimoto RI, Kirsch DR, Silverman RB. Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 56: 2665-75. PMID 23445362 DOI: 10.1021/Jm400079A |
0.324 |
|
| 2013 |
Ciryam P, Morimoto RI, Vendruscolo M, Dobson CM, O'Brien EP. In vivo translation rates can substantially delay the cotranslational folding of the Escherichia coli cytosolic proteome. Proceedings of the National Academy of Sciences of the United States of America. 110: E132-40. PMID 23256155 DOI: 10.1073/Pnas.1213624110 |
0.363 |
|
| 2012 |
Calamini B, Morimoto RI. Protein homeostasis as a therapeutic target for diseases of protein conformation. Current Topics in Medicinal Chemistry. 12: 2623-40. PMID 23339312 DOI: 10.2174/1568026611212220014 |
0.819 |
|
| 2012 |
Rampelt H, Kirstein-Miles J, Nillegoda NB, Chi K, Scholz SR, Morimoto RI, Bukau B. Metazoan Hsp70 machines use Hsp110 to power protein disaggregation. The Embo Journal. 31: 4221-35. PMID 22990239 DOI: 10.1038/Emboj.2012.264 |
0.527 |
|
| 2012 |
Lowth BR, Kirstein-Miles J, Saiyed T, Brötz-Oesterhelt H, Morimoto RI, Truscott KN, Dougan DA. Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX. Journal of Structural Biology. 179: 193-201. PMID 22710082 DOI: 10.1016/J.Jsb.2012.06.001 |
0.318 |
|
| 2012 |
Beam M, Silva MC, Morimoto RI. Dynamic imaging by fluorescence correlation spectroscopy identifies diverse populations of polyglutamine oligomers formed in vivo. The Journal of Biological Chemistry. 287: 26136-45. PMID 22669943 DOI: 10.1074/Jbc.M112.362764 |
0.801 |
|
| 2012 |
Klaić L, Morimoto RI, Silverman RB. Celastrol analogues as inducers of the heat shock response. Design and synthesis of affinity probes for the identification of protein targets. Acs Chemical Biology. 7: 928-37. PMID 22380712 DOI: 10.1021/Cb200539U |
0.445 |
|
| 2012 |
McMullen PD, Aprison EZ, Winter PB, Amaral LA, Morimoto RI, Ruvinsky I. Macro-level modeling of the response of C. elegans reproduction to chronic heat stress. Plos Computational Biology. 8: e1002338. PMID 22291584 DOI: 10.1371/Journal.Pcbi.1002338 |
0.702 |
|
| 2012 |
Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, Morimoto RI. Small-molecule proteostasis regulators for protein conformational diseases. Nature Chemical Biology. 8: 185-96. PMID 22198733 DOI: 10.1038/Nchembio.763 |
0.819 |
|
| 2012 |
Chen T, Benmohamed R, Kim J, Smith K, Amante D, Morimoto RI, Kirsch DR, Ferrante RJ, Silverman RB. ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 55: 515-27. PMID 22191331 DOI: 10.1021/Jm2014277 |
0.304 |
|
| 2012 |
Zhang W, Benmohamed R, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells. Bioorganic & Medicinal Chemistry. 20: 1029-45. PMID 22189273 DOI: 10.1016/J.Bmc.2011.11.039 |
0.309 |
|
| 2011 |
Morimoto RI. The heat shock response: systems biology of proteotoxic stress in aging and disease. Cold Spring Harbor Symposia On Quantitative Biology. 76: 91-9. PMID 22371371 DOI: 10.1101/Sqb.2012.76.010637 |
0.524 |
|
| 2011 |
Silva MC, Fox S, Beam M, Thakkar H, Amaral MD, Morimoto RI. A genetic screening strategy identifies novel regulators of the proteostasis network. Plos Genetics. 7: e1002438. PMID 22242008 DOI: 10.1371/Journal.Pgen.1002438 |
0.824 |
|
| 2011 |
Klaić L, Trippier PC, Mishra RK, Morimoto RI, Silverman RB. Remarkable stereospecific conjugate additions to the Hsp90 inhibitor celastrol. Journal of the American Chemical Society. 133: 19634-7. PMID 22087583 DOI: 10.1021/Ja208359A |
0.338 |
|
| 2011 |
Prahlad V, Morimoto RI. Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins. Proceedings of the National Academy of Sciences of the United States of America. 108: 14204-9. PMID 21844355 DOI: 10.1073/Pnas.1106557108 |
0.801 |
|
| 2011 |
Teixeira-Castro A, Ailion M, Jalles A, Brignull HR, Vilaça JL, Dias N, Rodrigues P, Oliveira JF, Neves-Carvalho A, Morimoto RI, Maciel P. Neuron-specific proteotoxicity of mutant ataxin-3 in C. elegans: rescue by the DAF-16 and HSF-1 pathways. Human Molecular Genetics. 20: 2996-3009. PMID 21546381 DOI: 10.1093/Hmg/Ddr203 |
0.799 |
|
| 2011 |
Gidalevitz T, Prahlad V, Morimoto RI. The stress of protein misfolding: from single cells to multicellular organisms. Cold Spring Harbor Perspectives in Biology. 3. PMID 21536706 DOI: 10.1101/Cshperspect.A009704 |
0.832 |
|
| 2011 |
Xia G, Benmohamed R, Kim J, Arvanites AC, Morimoto RI, Ferrante RJ, Kirsch DR, Silverman RB. Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 54: 2409-21. PMID 21375347 DOI: 10.1021/Jm101549K |
0.327 |
|
| 2011 |
Morimoto RI, Driessen AJ, Hegde RS, Langer T. The life of proteins: the good, the mostly good and the ugly. Nature Structural & Molecular Biology. 18: 1-4. PMID 21209622 DOI: 10.1038/Nsmb0111-1 |
0.367 |
|
| 2011 |
Benmohamed R, Arvanites AC, Kim J, Ferrante RJ, Silverman RB, Morimoto RI, Kirsch DR. Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group On Motor Neuron Diseases. 12: 87-96. PMID 21073276 DOI: 10.3109/17482968.2010.522586 |
0.328 |
|
| 2011 |
Petre I, Mizera A, Hyder CL, Meinander A, Mikhailov A, Morimoto RI, Sistonen L, Eriksson JE, Back RJ. A simple mass-action model for the eukaryotic heat shock response and its mathematical validation Natural Computing. 10: 595-612. DOI: 10.1007/S11047-010-9216-Y |
0.69 |
|
| 2010 |
Kikis EA, Gidalevitz T, Morimoto RI. Protein homeostasis in models of aging and age-related conformational disease. Advances in Experimental Medicine and Biology. 694: 138-59. PMID 20886762 DOI: 10.1007/978-1-4419-7002-2_11 |
0.787 |
|
| 2010 |
McMullen PD, Morimoto RI, Amaral LA. Physically grounded approach for estimating gene expression from microarray data. Proceedings of the National Academy of Sciences of the United States of America. 107: 13690-5. PMID 20643961 DOI: 10.1073/Pnas.1000938107 |
0.66 |
|
| 2010 |
Akerfelt M, Morimoto RI, Sistonen L. Heat shock factors: integrators of cell stress, development and lifespan. Nature Reviews. Molecular Cell Biology. 11: 545-55. PMID 20628411 DOI: 10.1038/Nrm2938 |
0.703 |
|
| 2010 |
Voisine C, Pedersen JS, Morimoto RI. Chaperone networks: tipping the balance in protein folding diseases. Neurobiology of Disease. 40: 12-20. PMID 20472062 DOI: 10.1016/J.Nbd.2010.05.007 |
0.471 |
|
| 2010 |
Kirstein-Miles J, Morimoto RI. Caenorhabditis elegans as a model system to study intercompartmental proteostasis: Interrelation of mitochondrial function, longevity, and neurodegenerative diseases. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 239: 1529-38. PMID 20419784 DOI: 10.1002/Dvdy.22292 |
0.388 |
|
| 2010 |
Kirstein-Miles J, Morimoto RI. Peptides signal mitochondrial stress. Cell Metabolism. 11: 177-8. PMID 20197049 DOI: 10.1016/J.Cmet.2010.02.011 |
0.359 |
|
| 2010 |
Gidalevitz T, Kikis EA, Morimoto RI. A cellular perspective on conformational disease: the role of genetic background and proteostasis networks. Current Opinion in Structural Biology. 20: 23-32. PMID 20053547 DOI: 10.1016/J.Sbi.2009.11.001 |
0.779 |
|
| 2010 |
Morimoto RI, Westerheide SD. The heat shock response and the stress of misfolded proteins Handbook of Cell Signaling, 2/E. 3: 2231-2239. DOI: 10.1016/B978-0-12-374145-5.00268-0 |
0.764 |
|
| 2010 |
Kikis EA, Ben-Zvi A, Morimoto RI. Caenorhabditis Elegans as a Model System to Study the Biology of Protein Aggregation and Toxicity Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 175-190. DOI: 10.1002/9780470572702.ch9 |
0.718 |
|
| 2009 |
Ben-Zvi A, Miller EA, Morimoto RI. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proceedings of the National Academy of Sciences of the United States of America. 106: 14914-9. PMID 19706382 DOI: 10.1073/Pnas.0902882106 |
0.767 |
|
| 2009 |
Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and chemical approaches to diseases of proteostasis deficiency. Annual Review of Biochemistry. 78: 959-91. PMID 19298183 DOI: 10.1146/Annurev.Biochem.052308.114844 |
0.444 |
|
| 2009 |
Gidalevitz T, Krupinski T, Garcia S, Morimoto RI. Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity. Plos Genetics. 5: e1000399. PMID 19266020 DOI: 10.1371/Journal.Pgen.1000399 |
0.767 |
|
| 2009 |
Sharabi K, Hurwitz A, Simon AJ, Beitel GJ, Morimoto RI, Rechavi G, Sznajder JI, Gruenbaum Y. Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 106: 4024-9. PMID 19237558 DOI: 10.1073/Pnas.0900309106 |
0.405 |
|
| 2009 |
Westerheide SD, Anckar J, Stevens SM, Sistonen L, Morimoto RI. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science (New York, N.Y.). 323: 1063-6. PMID 19229036 DOI: 10.1126/Science.1165946 |
0.832 |
|
| 2009 |
Morimoto RI, Cuervo AM. Protein homeostasis and aging: taking care of proteins from the cradle to the grave. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 64: 167-70. PMID 19228787 DOI: 10.1093/Gerona/Gln071 |
0.406 |
|
| 2009 |
Prahlad V, Morimoto RI. Integrating the stress response: lessons for neurodegenerative diseases from C. elegans. Trends in Cell Biology. 19: 52-61. PMID 19112021 DOI: 10.1016/J.Tcb.2008.11.002 |
0.799 |
|
| 2008 |
Morimoto RI. Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes & Development. 22: 1427-38. PMID 18519635 DOI: 10.1101/Gad.1657108 |
0.491 |
|
| 2008 |
Prahlad V, Cornelius T, Morimoto RI. Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons. Science (New York, N.Y.). 320: 811-4. PMID 18467592 DOI: 10.1126/Science.1156093 |
0.785 |
|
| 2008 |
Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting proteostasis for disease intervention. Science (New York, N.Y.). 319: 916-9. PMID 18276881 DOI: 10.1126/Science.1141448 |
0.412 |
|
| 2008 |
Trott A, West JD, Klai? L, Westerheide SD, Silverman RB, Morimoto RI, Morano KA. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Molecular Biology of the Cell. 19: 1104-12. PMID 18199679 DOI: 10.1091/Mbc.E07-10-1004 |
0.799 |
|
| 2008 |
Kim S, Morley JF, Ben-Zvi A, Morimoto RI. Polyglutamine Aggregates as a Model for Protein-misfolding Diseases Protein Folding Handbook. 3: 1175-1199. DOI: 10.1002/9783527619498.ch69 |
0.805 |
|
| 2007 |
Garcia SM, Casanueva MO, Silva MC, Amaral MD, Morimoto RI. Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells. Genes & Development. 21: 3006-16. PMID 18006691 DOI: 10.1101/Gad.1575307 |
0.417 |
|
| 2007 |
Zourlidou A, Gidalevitz T, Kristiansen M, Landles C, Woodman B, Wells DJ, Latchman DS, de Belleroche J, Tabrizi SJ, Morimoto RI, Bates GP. Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation. Human Molecular Genetics. 16: 1078-90. PMID 17360721 DOI: 10.1093/Hmg/Ddm057 |
0.794 |
|
| 2007 |
Brignull HR, Morley JF, Morimoto RI. The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging. Advances in Experimental Medicine and Biology. 594: 167-89. PMID 17205684 DOI: 10.1007/978-0-387-39975-1_15 |
0.828 |
|
| 2007 |
Voisine C, Orton K, Morimoto RI. Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System Molecular Neurology. 59-76. DOI: 10.1016/B978-012369509-3.50007-X |
0.796 |
|
| 2006 |
Morimoto RI. Stress, aging, and neurodegenerative disease. The New England Journal of Medicine. 355: 2254-5. PMID 17124027 DOI: 10.1056/Nejmcibr065573 |
0.314 |
|
| 2006 |
Brignull HR, Morley JF, Garcia SM, Morimoto RI. Modeling polyglutamine pathogenesis in C. elegans. Methods in Enzymology. 412: 256-82. PMID 17046663 DOI: 10.1016/S0076-6879(06)12016-9 |
0.819 |
|
| 2006 |
Finkbeiner S, Cuervo AM, Morimoto RI, Muchowski PJ. Disease-modifying pathways in neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10349-57. PMID 17035516 DOI: 10.1523/Jneurosci.3829-06.2006 |
0.351 |
|
| 2006 |
Kitamura A, Kubota H, Pack CG, Matsumoto G, Hirayama S, Takahashi Y, Kimura H, Kinjo M, Morimoto RI, Nagata K. Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. Nature Cell Biology. 8: 1163-70. PMID 16980958 DOI: 10.1038/Ncb1478 |
0.436 |
|
| 2006 |
Brignull HR, Moore FE, Tang SJ, Morimoto RI. Polyglutamine proteins at the pathogenic threshold display neuron-specific aggregation in a pan-neuronal Caenorhabditis elegans model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7597-606. PMID 16855087 DOI: 10.1523/Jneurosci.0990-06.2006 |
0.788 |
|
| 2006 |
Gidalevitz T, Ben-Zvi A, Ho KH, Brignull HR, Morimoto RI. Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science (New York, N.Y.). 311: 1471-4. PMID 16469881 DOI: 10.1126/Science.1124514 |
0.813 |
|
| 2006 |
Westerheide SD, Kawahara TL, Orton K, Morimoto RI. Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death. The Journal of Biological Chemistry. 281: 9616-22. PMID 16469748 DOI: 10.1074/Jbc.M512044200 |
0.839 |
|
| 2006 |
Matsumoto G, Kim S, Morimoto RI. Huntingtin and mutant SOD1 form aggregate structures with distinct molecular properties in human cells. The Journal of Biological Chemistry. 281: 4477-85. PMID 16371362 DOI: 10.1074/Jbc.M509201200 |
0.439 |
|
| 2006 |
Rieger TR, Morimoto RI, Hatzimanikatis V. Bistability explains threshold phenomena in protein aggregation both in vitro and in vivo. Biophysical Journal. 90: 886-95. PMID 16299080 DOI: 10.1529/Biophysj.105.066662 |
0.499 |
|
| 2006 |
Bukau B, Craig EA, Morimoto RI, Horwich AL. Stress-Induced Expression of Heat Shock Proteins and Action of the Heat Shock Protein Effectors Reviews in Cell Biology and Molecular Medicine. 463-516. DOI: 10.1002/3527600906.Mcb.200500068 |
0.538 |
|
| 2005 |
Matsumoto G, Stojanovic A, Holmberg CI, Kim S, Morimoto RI. Structural properties and neuronal toxicity of amyotrophic lateral sclerosis-associated Cu/Zn superoxide dismutase 1 aggregates. The Journal of Cell Biology. 171: 75-85. PMID 16216923 DOI: 10.1083/Jcb.200504050 |
0.393 |
|
| 2005 |
Westerheide SD, Morimoto RI. Heat shock response modulators as therapeutic tools for diseases of protein conformation. The Journal of Biological Chemistry. 280: 33097-100. PMID 16076838 DOI: 10.1074/Jbc.R500010200 |
0.804 |
|
| 2005 |
Rieger TR, Morimoto RI, Hatzimanikatis V. Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter. Biophysical Journal. 88: 1646-58. PMID 15626701 DOI: 10.1529/Biophysj.104.055301 |
0.58 |
|
| 2004 |
Westerheide SD, Bosman JD, Mbadugha BN, Kawahara TL, Matsumoto G, Kim S, Gu W, Devlin JP, Silverman RB, Morimoto RI. Celastrols as inducers of the heat shock response and cytoprotection. The Journal of Biological Chemistry. 279: 56053-60. PMID 15509580 DOI: 10.1074/Jbc.M409267200 |
0.8 |
|
| 2004 |
Holmberg CI, Staniszewski KE, Mensah KN, Matouschek A, Morimoto RI. Inefficient degradation of truncated polyglutamine proteins by the proteasome. The Embo Journal. 23: 4307-18. PMID 15470501 DOI: 10.1038/Sj.Emboj.7600426 |
0.451 |
|
| 2004 |
Solomon A, Bandhakavi S, Jabbar S, Shah R, Beitel GJ, Morimoto RI. Caenorhabditis elegans OSR-1 regulates behavioral and physiological responses to hyperosmotic environments. Genetics. 167: 161-70. PMID 15166144 DOI: 10.1534/Genetics.167.1.161 |
0.363 |
|
| 2004 |
Nollen EA, Garcia SM, van Haaften G, Kim S, Chavez A, Morimoto RI, Plasterk RH. Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation. Proceedings of the National Academy of Sciences of the United States of America. 101: 6403-8. PMID 15084750 DOI: 10.1073/Pnas.0307697101 |
0.739 |
|
| 2004 |
Mosser DD, Morimoto RI. Molecular chaperones and the stress of oncogenesis. Oncogene. 23: 2907-18. PMID 15077153 DOI: 10.1038/Sj.Onc.1207529 |
0.533 |
|
| 2004 |
Morley JF, Morimoto RI. Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones. Molecular Biology of the Cell. 15: 657-64. PMID 14668486 DOI: 10.1091/Mbc.E03-07-0532 |
0.729 |
|
| 2003 |
Colón-Ramos DA, Irusta PM, Gan EC, Olson MR, Song J, Morimoto RI, Elliott RM, Lombard M, Hollingsworth R, Hardwick JM, Smith GK, Kornbluth S. Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. Molecular Biology of the Cell. 14: 4162-72. PMID 14517326 DOI: 10.1091/Mbc.E03-03-0139 |
0.422 |
|
| 2003 |
Morimoto RI, Nollen EAA. The Heat-Shock Response: Sensing the Stress of Misfolded Proteins Handbook of Cell Signaling. 3: 269-275. DOI: 10.1016/B978-012124546-7/50672-0 |
0.734 |
|
| 2002 |
Kim S, Nollen EA, Kitagawa K, Bindokas VP, Morimoto RI. Polyglutamine protein aggregates are dynamic. Nature Cell Biology. 4: 826-31. PMID 12360295 DOI: 10.1038/Ncb863 |
0.742 |
|
| 2002 |
Morimoto RI. Dynamic remodeling of transcription complexes by molecular chaperones. Cell. 110: 281-4. PMID 12176314 DOI: 10.1016/S0092-8674(02)00860-7 |
0.433 |
|
| 2002 |
Morley JF, Brignull HR, Weyers JJ, Morimoto RI. The threshold for polyglutamine-expansion protein aggregation and cellular toxicity is dynamic and influenced by aging in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 99: 10417-22. PMID 12122205 DOI: 10.1073/Pnas.152161099 |
0.814 |
|
| 2002 |
Nollen EA, Morimoto RI. Chaperoning signaling pathways: molecular chaperones as stress-sensing 'heat shock' proteins. Journal of Cell Science. 115: 2809-16. PMID 12082142 |
0.753 |
|
| 2002 |
Jolly C, Konecny L, Grady DL, Kutskova YA, Cotto JJ, Morimoto RI, Vourc'h C. In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress. The Journal of Cell Biology. 156: 775-81. PMID 11877455 DOI: 10.1083/Jcb.200109018 |
0.44 |
|
| 2002 |
Tai LJ, McFall SM, Huang K, Demeler B, Fox SG, Brubaker K, Radhakrishnan I, Morimoto RI. Structure-function analysis of the heat shock factor-binding protein reveals a protein composed solely of a highly conserved and dynamic coiled-coil trimerization domain. The Journal of Biological Chemistry. 277: 735-45. PMID 11679589 DOI: 10.1074/Jbc.M108604200 |
0.697 |
|
| 2001 |
Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 107: 893-903. PMID 11779465 DOI: 10.1016/S0092-8674(01)00612-2 |
0.429 |
|
| 2001 |
Mathew A, Mathur SK, Jolly C, Fox SG, Kim S, Morimoto RI. Stress-specific activation and repression of heat shock factors 1 and 2. Molecular and Cellular Biology. 21: 7163-71. PMID 11585899 DOI: 10.1128/Mcb.21.21.7163-7171.2001 |
0.522 |
|
| 2001 |
Ahn SG, Liu PC, Klyachko K, Morimoto RI, Thiele DJ. The loop domain of heat shock transcription factor 1 dictates DNA-binding specificity and responses to heat stress. Genes & Development. 15: 2134-45. PMID 11511544 DOI: 10.1101/Gad.894801 |
0.474 |
|
| 2001 |
Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, Sistonen L. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. The Embo Journal. 20: 3800-10. PMID 11447121 DOI: 10.1093/Emboj/20.14.3800 |
0.648 |
|
| 2001 |
Carr VM, Menco BP, Yankova MP, Morimoto RI, Farbman AI. Odorants as cell-type specific activators of a heat shock response in the rat olfactory mucosa. The Journal of Comparative Neurology. 432: 425-39. PMID 11268007 DOI: 10.1002/Cne.1112 |
0.441 |
|
| 2001 |
Song J, Takeda M, Morimoto RI. Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth. Nature Cell Biology. 3: 276-82. PMID 11231577 DOI: 10.1038/35060068 |
0.455 |
|
| 2001 |
Thress K, Song J, Morimoto RI, Kornbluth S. Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. The Embo Journal. 20: 1033-41. PMID 11230127 DOI: 10.1093/Emboj/20.5.1033 |
0.459 |
|
| 2000 |
Jolly C, Morimoto RI. Role of the heat shock response and molecular chaperones in oncogenesis and cell death. Journal of the National Cancer Institute. 92: 1564-72. PMID 11018092 DOI: 10.1093/Jnci/92.19.1564 |
0.532 |
|
| 2000 |
Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B. The chaperone function of hsp70 is required for protection against stress-induced apoptosis. Molecular and Cellular Biology. 20: 7146-59. PMID 10982831 DOI: 10.1128/Mcb.20.19.7146-7159.2000 |
0.471 |
|
| 2000 |
Beere HM, Wolf BB, Cain K, Mosser DD, Mahboubi A, Kuwana T, Tailor P, Morimoto RI, Cohen GM, Green DR. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nature Cell Biology. 2: 469-75. PMID 10934466 DOI: 10.1038/35019501 |
0.464 |
|
| 2000 |
Mathew A, Shi Y, Jolly C, Morimoto RI. Analysis of the mammalian heat-shock response. Inducible gene expression and heat-shock factor activity. Methods in Molecular Biology (Clifton, N.J.). 99: 217-55. PMID 10909088 DOI: 10.1385/1-59259-054-3:217 |
0.465 |
|
| 2000 |
Satyal SH, Schmidt E, Kitagawa K, Sondheimer N, Lindquist S, Kramer JM, Morimoto RI. Polyglutamine aggregates alter protein folding homeostasis in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 97: 5750-5. PMID 10811890 DOI: 10.1073/Pnas.100107297 |
0.84 |
|
| 2000 |
Nollen EA, Brunsting JF, Song J, Kampinga HH, Morimoto RI. Bag1 functions in vivo as a negative regulator of Hsp70 chaperone activity. Molecular and Cellular Biology. 20: 1083-8. PMID 10629065 DOI: 10.1128/Mcb.20.3.1083-1088.2000 |
0.755 |
|
| 1999 |
Wang SM, Khandekar JD, Kaul KL, Winchester DJ, Morimoto RI. A method for the quantitative analysis of human heat shock gene expression using a multiplex RT-PCR assay. Cell Stress & Chaperones. 4: 153-61. PMID 10547064 DOI: 10.1379/1466-1268(1999)004<0153:Amftqa>2.3.Co;2 |
0.456 |
|
| 1999 |
Jolly C, Vourc'h C, Robert-Nicoud M, Morimoto RI. Intron-independent association of splicing factors with active genes. The Journal of Cell Biology. 145: 1133-43. PMID 10366587 DOI: 10.1083/Jcb.145.6.1133 |
0.426 |
|
| 1999 |
Jolly C, Usson Y, Morimoto RI. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proceedings of the National Academy of Sciences of the United States of America. 96: 6769-74. PMID 10359787 DOI: 10.1073/Pnas.96.12.6769 |
0.48 |
|
| 1999 |
Osipiuk J, Walsh MA, Freeman BC, Morimoto RI, Joachimiak A. Structure of a new crystal form of human Hsp70 ATPase domain. Acta Crystallographica. Section D, Biological Crystallography. 55: 1105-7. PMID 10216320 DOI: 10.1107/S0907444999002103 |
0.442 |
|
| 1999 |
Cotto JJ, Morimoto RI. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors. Biochemical Society Symposium. 64: 105-18. PMID 10207624 |
0.469 |
|
| 1999 |
Carr VM, Morimoto RI, Farbman AI. Development and further characterization of a small subclass of rat olfactory receptor neurons that shows immunoreactivity for the HSP70 heat shock protein. The Journal of Comparative Neurology. 404: 375-86. PMID 9952354 DOI: 10.1002/(Sici)1096-9861(19990215)404:3<375::Aid-Cne7>3.0.Co;2-8 |
0.315 |
|
| 1999 |
Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG. The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. The Journal of Biological Chemistry. 274: 3797-803. PMID 9920933 DOI: 10.1074/Jbc.274.6.3797 |
0.427 |
|
| 1999 |
Shi Y, Morimoto RI. Autoregulation of the Heat Shock Response Handbook of Experimental Pharmacology. 136: 225-241. DOI: 10.1007/978-3-642-58259-2_10 |
0.516 |
|
| 1998 |
Morimoto RI. Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators. Genes & Development. 12: 3788-96. PMID 9869631 DOI: 10.1101/Gad.12.24.3788 |
0.474 |
|
| 1998 |
Bimston D, Song J, Winchester D, Takayama S, Reed JC, Morimoto RI. BAG-1, a negative regulator of Hsp70 chaperone activity, uncouples nucleotide hydrolysis from substrate release. The Embo Journal. 17: 6871-8. PMID 9843493 DOI: 10.1093/Emboj/17.23.6871 |
0.479 |
|
| 1998 |
Morimoto RI, Santoro MG. Stress-inducible responses and heat shock proteins: new pharmacologic targets for cytoprotection. Nature Biotechnology. 16: 833-8. PMID 9743115 DOI: 10.1038/Nbt0998-833 |
0.523 |
|
| 1998 |
Mathew A, Mathur SK, Morimoto RI. Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Molecular and Cellular Biology. 18: 5091-8. PMID 9710593 DOI: 10.1128/Mcb.18.9.5091 |
0.537 |
|
| 1998 |
Mathew A, Morimoto RI. Role of the heat-shock response in the life and death of proteins. Annals of the New York Academy of Sciences. 851: 99-111. PMID 9668611 DOI: 10.1111/J.1749-6632.1998.Tb08982.X |
0.556 |
|
| 1998 |
Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI. Negative regulation of the heat shock transcriptional response by HSBP1. Genes & Development. 12: 1962-74. PMID 9649501 DOI: 10.1101/Gad.12.13.1962 |
0.846 |
|
| 1998 |
Furukawa M, Uchiumi T, Nomoto M, Takano H, Morimoto RI, Naito S, Kuwano M, Kohno K. The role of an inverted CCAAT element in transcriptional activation of the human DNA topoisomerase IIalpha gene by heat shock. The Journal of Biological Chemistry. 273: 10550-5. PMID 9553115 DOI: 10.1074/Jbc.273.17.10550 |
0.48 |
|
| 1998 |
Tanabe M, Kawazoe Y, Takeda S, Morimoto RI, Nagata K, Nakai A. Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. The Embo Journal. 17: 1750-8. PMID 9501096 DOI: 10.1093/Emboj/17.6.1750 |
0.689 |
|
| 1998 |
Shi Y, Mosser DD, Morimoto RI. Molecular chaperones as HSF1-specific transcriptional repressors. Genes & Development. 12: 654-66. PMID 9499401 DOI: 10.1101/Gad.12.5.654 |
0.513 |
|
| 1998 |
Satyal SH, Morimoto RI. Biochemical events in the activation and attenuation of the heat shock transcriptional response Journal of Biosciences. 23: 303-311. DOI: 10.1007/Bf02936123 |
0.842 |
|
| 1997 |
Morimoto RI, Kline MP, Bimston DN, Cotto JJ. The heat-shock response: regulation and function of heat-shock proteins and molecular chaperones. Essays in Biochemistry. 32: 17-29. PMID 9493008 |
0.486 |
|
| 1997 |
Jolly C, Morimoto RI, Robert-Nicoud M, Vourc'h C. HSF1 transcription factor concentrates in nuclear foci during heat shock: Relationship with transcription sites Journal of Cell Science. 110: 2935-2941. PMID 9359877 |
0.359 |
|
| 1997 |
Cotto JJ, Fox SG, Morimoto RI. HSF1 granules: A novel stress-induced nuclear compartment of human cells Journal of Cell Science. 110: 2925-2934. PMID 9359875 |
0.419 |
|
| 1997 |
Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. The Embo Journal. 16: 4887-96. PMID 9305631 DOI: 10.1093/Emboj/16.16.4887 |
0.52 |
|
| 1997 |
Kimura Y, Rutherford SL, Miyata Y, Yahara I, Freeman BC, Yue L, Morimoto RI, Lindquist S. Cdc37 is a molecular chaperone with specific functions in signal transduction. Genes & Development. 11: 1775-85. PMID 9242486 DOI: 10.1101/Gad.11.14.1775 |
0.575 |
|
| 1997 |
Kanei-Ishii C, Tanikawa J, Nakai A, Morimoto RI, Ishii S. Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science (New York, N.Y.). 277: 246-8. PMID 9211854 DOI: 10.1126/Science.277.5323.246 |
0.653 |
|
| 1997 |
Rallu M, Loones M, Lallemand Y, Morimoto R, Morange M, Mezger V. Function and regulation of heat shock factor 2 during mouse embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 94: 2392-7. PMID 9122205 DOI: 10.1073/Pnas.94.6.2392 |
0.523 |
|
| 1997 |
Kline MP, Morimoto RI. Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Molecular and Cellular Biology. 17: 2107-15. PMID 9121459 DOI: 10.1128/Mcb.17.4.2107 |
0.428 |
|
| 1997 |
Sriram, Osipiuk J, Freeman BC, Morimoto RI, Joachimiak A. Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain Structure. 5: 403-414. PMID 9083109 DOI: 10.1016/S0969-2126(97)00197-4 |
0.6 |
|
| 1997 |
Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Molecular and Cellular Biology. 17: 469-81. PMID 8972228 DOI: 10.1128/Mcb.17.1.469 |
0.685 |
|
| 1997 |
Sistonen L, Morimoto RI. Characterization of in Vivo DNA-Protein Interactions in the Transcriptional Regulation of Human Heat Shock Genes Advances in Molecular and Cell Biology. 21: 111-134. DOI: 10.1016/S1569-2558(08)60284-2 |
0.701 |
|
| 1996 |
Hansen S, Midgley CA, Lane DP, Freeman BC, Morimoto RI, Hupp TR. Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70. The Journal of Biological Chemistry. 271: 30922-8. PMID 8940078 DOI: 10.1074/Jbc.271.48.30922 |
0.344 |
|
| 1996 |
Freeman BC, Toft DO, Morimoto RI. Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23. Science (New York, N.Y.). 274: 1718-20. PMID 8939864 DOI: 10.1126/Science.274.5293.1718 |
0.411 |
|
| 1996 |
Morimoto RI, Kroeger PE, Cotto JJ. The transcriptional regulation of heat shock genes: a plethora of heat shock factors and regulatory conditions. Exs. 77: 139-63. PMID 8856973 |
0.396 |
|
| 1996 |
Freeman BC, Morimoto RI. The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. The Embo Journal. 15: 2969-79. PMID 8670798 DOI: 10.1002/J.1460-2075.1996.Tb00660.X |
0.435 |
|
| 1996 |
Cotto JJ, Kline M, Morimoto RI. Activation of heat shock factor 1 DNA binding precedes stress-induced serine phosphorylation. Evidence for a multistep pathway of regulation. The Journal of Biological Chemistry. 271: 3355-8. PMID 8631933 DOI: 10.1074/Jbc.271.7.3355 |
0.442 |
|
| 1996 |
Marcuccilli CJ, Mathur SK, Morimoto RI, Miller RJ. Regulatory differences in the stress response of hippocampal neurons and glial cells after heat shock. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 478-85. PMID 8551332 DOI: 10.1523/Jneurosci.16-02-00478.1996 |
0.466 |
|
| 1995 |
Bhattacharyya T, Karnezis AN, Murphy SP, Hoang T, Freeman BC, Phillips B, Morimoto RI. Cloning and subcellular localization of human mitochondrial hsp70. The Journal of Biological Chemistry. 270: 1705-10. PMID 7829505 DOI: 10.1074/Jbc.270.4.1705 |
0.386 |
|
| 1995 |
Freeman BC, Myers MP, Schumacher R, Morimoto RI. Identification of a regulatory motif in Hsp70 that affects ATPase activity, substrate binding and interaction with HDJ-1. The Embo Journal. 14: 2281-92. PMID 7774586 DOI: 10.1002/J.1460-2075.1995.Tb07222.X |
0.411 |
|
| 1995 |
Lee BS, Chen J, Angelidis C, Jurivich DA, Morimoto RI. Pharmacological modulation of heat shock factor 1 by antiinflammatory drugs results in protection against stress-induced cellular damage. Proceedings of the National Academy of Sciences of the United States of America. 92: 7207-11. PMID 7638169 DOI: 10.1073/Pnas.92.16.7207 |
0.489 |
|
| 1995 |
Shi Y, Kroeger PE, Morimoto RI. The carboxyl-terminal transactivation domain of heat shock factor 1 is negatively regulated and stress responsive. Molecular and Cellular Biology. 15: 4309-18. PMID 7623825 DOI: 10.1128/Mcb.15.8.4309 |
0.386 |
|
| 1995 |
Nakai A, Kawazoe Y, Tanabe M, Nagata K, Morimoto RI. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Molecular and Cellular Biology. 15: 5268-78. PMID 7565675 DOI: 10.1128/Mcb.15.10.5268 |
0.653 |
|
| 1994 |
Jurivich DA, Sistonen L, Sarge KD, Morimoto RI. Arachidonate is a potent modulator of human heat shock gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 91: 2280-4. PMID 8134388 DOI: 10.1073/Pnas.91.6.2280 |
0.673 |
|
| 1994 |
Sistonen L, Sarge KD, Morimoto RI. Human heat shock factors 1 and 2 are differentially activated and can synergistically induce hsp70 gene transcription. Molecular and Cellular Biology. 14: 2087-99. PMID 8114740 DOI: 10.1128/mcb.14.3.2087-2099.1994 |
0.692 |
|
| 1994 |
Sarge KD, Park-Sarge OK, Kirby JD, Mayo KE, Morimoto RI. Expression of heat shock factor 2 in mouse testis: potential role as a regulator of heat-shock protein gene expression during spermatogenesis. Biology of Reproduction. 50: 1334-43. PMID 8080921 DOI: 10.1095/Biolreprod50.6.1334 |
0.455 |
|
| 1994 |
Mathur SK, Sistonen L, Brown IR, Murphy SP, Sarge KD, Morimoto RI. Deficient induction of human hsp70 heat shock gene transcription in Y79 retinoblastoma cells despite activation of heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 91: 8695-9. PMID 8078944 DOI: 10.1073/Pnas.91.18.8695 |
0.709 |
|
| 1994 |
Li WW, Sistonen L, Morimoto RI, Lee AS. Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element. Molecular and Cellular Biology. 14: 5533-46. PMID 8035828 DOI: 10.1128/mcb.14.8.5533-5546.1994 |
0.647 |
|
| 1994 |
Kroeger PE, Morimoto RI. Selection of new HSF1 and HSF2 DNA-binding sites reveals difference in trimer cooperativity. Molecular and Cellular Biology. 14: 7592-603. PMID 7935474 DOI: 10.1128/mcb.14.11.7592-7603.1994 |
0.369 |
|
| 1994 |
Carr VM, Murphy SP, Morimoto RI, Farbman AI. Small subclass of rat olfactory neurons with specific bulbar projections is reactive with monoclonal antibodies to the HSP70 heat shock protein. The Journal of Comparative Neurology. 348: 150-60. PMID 7814683 DOI: 10.1002/Cne.903480109 |
0.338 |
|
| 1994 |
Mezger V, Rallu M, Morimoto RI, Morange M, Renard JP. Heat shock factor 2-like activity in mouse blastocysts. Developmental Biology. 166: 819-22. PMID 7813800 DOI: 10.1006/Dbio.1994.1361 |
0.478 |
|
| 1994 |
Fawcett TW, Sylvester SL, Sarge KD, Morimoto RI, Holbrook NJ. Effects of neurohormonal stress and aging on the activation of mammalian heat shock factor 1. The Journal of Biological Chemistry. 269: 32272-8. PMID 7798227 |
0.303 |
|
| 1994 |
Morimoto RI, Jurivich DA, Kroeger PE, Mathur SK, Murphy SP, Nakai A, Sarge K, Abravaya K, Sistonen LT. 17 Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors Cold Spring Harbor Monograph Archive. 26: 417-455. DOI: 10.1101/087969427.26.417 |
0.835 |
|
| 1994 |
Morimoto RI, Tissières A, Georgopoulos C. 1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones Cold Spring Harbor Monograph Archive. 26: 1-30. DOI: 10.1101/087969427.26.1 |
0.506 |
|
| 1993 |
Kroeger PE, Sarge KD, Morimoto RI. Mouse heat shock transcription factors 1 and 2 prefer a trimeric binding site but interact differently with the HSP70 heat shock element. Molecular and Cellular Biology. 13: 3370-83. PMID 8497256 DOI: 10.1128/mcb.13.6.3370-3383.1993 |
0.361 |
|
| 1993 |
Nakai A, Morimoto RI. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Molecular and Cellular Biology. 13: 1983-97. PMID 8455593 DOI: 10.1128/mcb.13.4.1983-1997.1993 |
0.649 |
|
| 1993 |
Morimoto RI. Cells in stress: transcriptional activation of heat shock genes. Science (New York, N.Y.). 259: 1409-10. PMID 8451637 DOI: 10.1126/Science.8451637 |
0.465 |
|
| 1993 |
Sarge KD, Murphy SP, Morimoto RI. Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress. Molecular and Cellular Biology. 13: 1392-407. PMID 8441385 DOI: 10.1128/mcb.13.3.1392-1407.1993 |
0.485 |
|
| 1993 |
Beere HM, Morimoto RI, Hickman JA. Investigations of mechanisms of drug-induced changes in gene expression: N-methylformamide-induced changes in synthesis of the M(r) 72,000 constitutive heat shock protein during commitment of HL-60 cells to granulocyte differentiation. Cancer Research. 53: 3034-9. PMID 8319210 |
0.415 |
|
| 1992 |
Amici C, Sistonen L, Santoro MG, Morimoto RI. Antiproliferative prostaglandins activate heat shock transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 89: 6227-31. PMID 1631114 DOI: 10.1073/Pnas.89.14.6227 |
0.695 |
|
| 1992 |
Abravaya K, Myers MP, Murphy SP, Morimoto RI. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes & Development. 6: 1153-64. PMID 1628823 DOI: 10.1101/Gad.6.7.1153 |
0.78 |
|
| 1992 |
Jurivich DA, Sistonen L, Kroes RA, Morimoto RI. Effect of sodium salicylate on the human heat shock response. Science (New York, N.Y.). 255: 1243-5. PMID 1546322 DOI: 10.1126/Science.1546322 |
0.696 |
|
| 1992 |
Sistonen L, Sarge KD, Phillips B, Abravaya K, Morimoto RI. Activation of heat shock factor 2 during hemin-induced differentiation of human erythroleukemia cells. Molecular and Cellular Biology. 12: 4104-11. PMID 1508207 DOI: 10.1128/mcb.12.9.4104-4111.1992 |
0.824 |
|
| 1992 |
Morimoto RI. Transcription factors: positive and negative regulators of cell growth and disease. Current Opinion in Cell Biology. 4: 480-7. PMID 1497920 DOI: 10.1016/0955-0674(92)90015-5 |
0.372 |
|
| 1992 |
Morimoto RI, Sarge KD, Abravaya K. Transcriptional regulation of heat shock genes. A paradigm for inducible genomic responses. The Journal of Biological Chemistry. 267: 21987-90. PMID 1429548 |
0.766 |
|
| 1992 |
Beere H, Morimoto R, Waters C, Parmar R, Hickman J. 118. Changes in the levels of constitutively expressed but not stress-induced heat shock proteins during terminal differentiation of HL-60 human leukemia cells Biomedicine & Pharmacotherapy. 46: 297. DOI: 10.1016/0753-3322(92)90203-J |
0.486 |
|
| 1991 |
Kroes RA, Abravaya K, Seidenfeld J, Morimoto RI. Selective activation of human heat shock gene transcription by nitrosourea antitumor drugs mediated by isocyanate-induced damage and activation of heat shock transcription factor. Proceedings of the National Academy of Sciences of the United States of America. 88: 4825-9. PMID 2052560 DOI: 10.1073/Pnas.88.11.4825 |
0.786 |
|
| 1991 |
Watowich SS, Morimoto RI, Lamb RA. Flux of the paramyxovirus hemagglutinin-neuraminidase glycoprotein through the endoplasmic reticulum activates transcription of the GRP78-BiP gene. Journal of Virology. 65: 3590-7. PMID 2041085 DOI: 10.1128/Jvi.65.7.3590-3597.1991 |
0.657 |
|
| 1991 |
Abravaya K, Phillips B, Morimoto RI. Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting. Molecular and Cellular Biology. 11: 586-92. PMID 1986252 DOI: 10.1128/Mcb.11.1.586 |
0.763 |
|
| 1991 |
Fujita H, Yamamoto M, Yamagami T, Hayashi N, Bishop TR, De Verneuil H, Yoshinaga T, Shibahara S, Morimoto R, Sassa S. Sequential activation of genes for heme pathway enzymes during erythroid differentiation of mouse Friend virus-transformed erythroleukemia cells. Biochimica Et Biophysica Acta. 1090: 311-6. PMID 1954253 DOI: 10.1016/0167-4781(91)90195-R |
0.372 |
|
| 1991 |
Abravaya K, Phillips B, Morimoto RI. Attenuation of the heat shock response in HeLa cells is mediated by the release of bound heat shock transcription factor and is modulated by changes in growth and in heat shock temperatures. Genes & Development. 5: 2117-27. PMID 1936996 DOI: 10.1101/Gad.5.11.2117 |
0.762 |
|
| 1991 |
Sarge KD, Morimoto RI. Surprising features of transcriptional regulation of heat shock genes. Gene Expression. 1: 169-73. PMID 1820215 |
0.317 |
|
| 1991 |
Phillips B, Morimoto RI. Transcriptional regulation of human hsp70 genes: relationship between cell growth, differentiation, virus infection, and the stress response. Results and Problems in Cell Differentiation. 17: 167-87. PMID 1803419 DOI: 10.1007/978-3-540-46712-0_12 |
0.381 |
|
| 1991 |
Sarge KD, Zimarino V, Holm K, Wu C, Morimoto RI. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes & Development. 5: 1902-11. PMID 1717345 DOI: 10.1101/Gad.5.10.1902 |
0.456 |
|
| 1991 |
Phillips B, Abravaya K, Morimoto RI. Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses. Journal of Virology. 65: 5680-92. PMID 1656064 DOI: 10.1128/Jvi.65.11.5680-5692.1991 |
0.734 |
|
| 1991 |
Koskinen PJ, Sistonen L, Evan G, Morimoto R, Alitalo K. Nuclear colocalization of cellular and viral myc proteins with HSP70 in myc-overexpressing cells. Journal of Virology. 65: 842-851. DOI: 10.1128/Jvi.65.2.842-851.1991 |
0.69 |
|
| 1990 |
Alvares K, Carrillo A, Yuan PM, Kawano H, Morimoto RI, Reddy JK. Identification of cytosolic peroxisome proliferator binding protein as a member of the heat shock protein HSP70 family. Proceedings of the National Academy of Sciences of the United States of America. 87: 5293-7. PMID 2371272 DOI: 10.1073/Pnas.87.14.5293 |
0.439 |
|
| 1990 |
Ovsenek N, Williams GT, Morimoto RI, Heikkila JJ. cis-acting sequences and trans-acting factors required for constitutive expression of a microinjected HSP70 gene after the midblastula transition of Xenopus laevis embryogenesis. Developmental Genetics. 11: 97-109. PMID 2361336 DOI: 10.1002/Dvg.1020110111 |
0.368 |
|
| 1990 |
Williams GT, Morimoto RI. Maximal stress-induced transcription from the human HSP70 promoter requires interactions with the basal promoter elements independent of rotational alignment. Molecular and Cellular Biology. 10: 3125-36. PMID 2342471 DOI: 10.1128/mcb.10.6.3125-3136.1990 |
0.435 |
|
| 1990 |
Mosser DD, Kotzbauer PT, Sarge KD, Morimoto RI. In vitro activation of heat shock transcription factor DNA-binding by calcium and biochemical conditions that affect protein conformation. Proceedings of the National Academy of Sciences of the United States of America. 87: 3748-52. PMID 2339118 DOI: 10.1073/Pnas.87.10.3748 |
0.472 |
|
| 1990 |
Morimoto RI, Tissières A, Georgopoulos C. Preface/Front Matter Cold Spring Harbor Monograph Archive. 19. DOI: 10.1101/087969337.19.I |
0.53 |
|
| 1990 |
Morimoto RI, Milarski KL. 14 Expression and Function of Vertebrate hsp70 Genes Cold Spring Harbor Monograph Archive. 19: 323-359. DOI: 10.1101/087969337.19.323 |
0.481 |
|
| 1990 |
Morimoto RI, Tissières A, Georgopoulos C. 1 The Stress Response, Function of the Proteins, and Perspectives Cold Spring Harbor Monograph Archive. 19: 1-36. DOI: 10.1101/087969337.19.1 |
0.493 |
|
| 1990 |
MORIMOTO R. Transcriptional regulation of human HSP70 genes Cell Biology International Reports. 14: 7. DOI: 10.1016/0309-1651(90)90139-P |
0.37 |
|
| 1989 |
Theodorakis NG, Zand DJ, Kotzbauer PT, Williams GT, Morimoto RI. Hemin-induced transcriptional activation of the HSP70 gene during erythroid maturation in K562 cells is due to a heat shock factor-mediated stress response. Molecular and Cellular Biology. 9: 3166-73. PMID 2796986 DOI: 10.1128/mcb.9.8.3166-3173.1989 |
0.515 |
|
| 1989 |
Milarski KL, Morimoto RI. Mutational analysis of the human HSP70 protein: distinct domains for nucleolar localization and adenosine triphosphate binding. The Journal of Cell Biology. 109: 1947-62. PMID 2681224 DOI: 10.1083/Jcb.109.5.1947 |
0.464 |
|
| 1989 |
Milarski KL, Welch WJ, Morimoto RI. Cell cycle-dependent association of HSP70 with specific cellular proteins. The Journal of Cell Biology. 108: 413-23. PMID 2645297 DOI: 10.1083/Jcb.108.2.413 |
0.486 |
|
| 1989 |
Williams GT, McClanahan TK, Morimoto RI. E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex. Molecular and Cellular Biology. 9: 2574-87. PMID 2474756 DOI: 10.1128/mcb.9.6.2574-2587.1989 |
0.365 |
|
| 1988 |
Ferris DK, Harel-Bellan A, Morimoto RI, Welch WJ, Farrar WL. Mitogen and lymphokine stimulation of heat shock proteins in T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 85: 3850-4. PMID 3287377 DOI: 10.1073/Pnas.85.11.3850 |
0.44 |
|
| 1988 |
Watowich SS, Morimoto RI. Complex regulation of heat shock- and glucose-responsive genes in human cells. Molecular and Cellular Biology. 8: 393-405. PMID 3275876 DOI: 10.1128/mcb.8.1.393-405.1988 |
0.676 |
|
| 1988 |
Mosser DD, Theodorakis NG, Morimoto RI. Coordinate changes in heat shock element-binding activity and HSP70 gene transcription rates in human cells. Molecular and Cellular Biology. 8: 4736-44. PMID 3211126 DOI: 10.1128/mcb.8.11.4736-4744.1988 |
0.491 |
|
| 1988 |
Theodorakis NG, Banerji SS, Morimoto RI. HSP70 mRNA translation in chicken reticulocytes is regulated at the level of elongation. The Journal of Biological Chemistry. 263: 14579-85. PMID 3170555 |
0.793 |
|
| 1988 |
Schaefer EL, Morimoto RI, Theodorakis NG, Seidenfeld J. Chemical specificity for induction of stress response genes by DNA-damaging drugs in human adenocarcinoma cells. Carcinogenesis. 9: 1733-8. PMID 3168151 DOI: 10.1093/Carcin/9.10.1733 |
0.403 |
|
| 1987 |
Morgan WD, Williams GT, Morimoto RI, Greene J, Kingston RE, Tjian R. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Molecular and Cellular Biology. 7: 1129-38. PMID 3561411 DOI: 10.1128/mcb.7.3.1129-1138.1987 |
0.439 |
|
| 1987 |
Harrison GS, Drabkin HA, Kao FT, Hartz J, Hart IM, Chu EH, Wu BJ, Morimoto RI. Chromosomal location of human genes encoding major heat-shock protein HSP70. Somatic Cell and Molecular Genetics. 13: 119-30. PMID 3470951 DOI: 10.1007/Bf01534692 |
0.494 |
|
| 1987 |
Moore M, Schaack J, Baim SB, Morimoto RI, Shenk T. Induced heat shock mRNAs escape the nucleocytoplasmic transport block in adenovirus-infected HeLa cells. Molecular and Cellular Biology. 7: 4505-12. PMID 3437895 DOI: 10.1128/mcb.7.12.4505-4512.1987 |
0.364 |
|
| 1987 |
Theodorakis NG, Morimoto RI. Posttranscriptional regulation of hsp70 expression in human cells: effects of heat shock, inhibition of protein synthesis, and adenovirus infection on translation and mRNA stability. Molecular and Cellular Biology. 7: 4357-68. PMID 3437893 DOI: 10.1128/mcb.7.12.4357-4368.1987 |
0.48 |
|
| 1987 |
Banerji SS, Laing K, Morimoto RI. Erythroid lineage-specific expression and inducibility of the major heat shock protein HSP70 during avian embryogenesis. Genes & Development. 1: 946-53. PMID 3428602 DOI: 10.1101/Gad.1.9.946 |
0.817 |
|
| 1987 |
Wu BJ, Williams GT, Morimoto RI. Detection of three protein binding sites in the serum-regulated promoter of the human gene encoding the 70-kDa heat shock protein. Proceedings of the National Academy of Sciences of the United States of America. 84: 2203-7. PMID 3031671 DOI: 10.1073/Pnas.84.8.2203 |
0.487 |
|
| 1986 |
Banerji SS, Berg L, Morimoto RI. Transcription and post-transcriptional regulation of avian HSP70 gene expression. The Journal of Biological Chemistry. 261: 15740-5. PMID 3782087 |
0.808 |
|
| 1986 |
Milarski KL, Morimoto RI. Expression of human HSP70 during the synthetic phase of the cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 83: 9517-21. PMID 3540942 DOI: 10.1073/Pnas.83.24.9517 |
0.467 |
|
| 1986 |
Wu BJ, Hurst HC, Jones NC, Morimoto RI. The E1A 13S product of adenovirus 5 activates transcription of the cellular human HSP70 gene. Molecular and Cellular Biology. 6: 2994-9. PMID 3491295 DOI: 10.1128/mcb.6.8.2994-2999.1986 |
0.426 |
|
| 1986 |
Wu BJ, Kingston RE, Morimoto RI. Human HSP70 promoter contains at least two distinct regulatory domains. Proceedings of the National Academy of Sciences of the United States of America. 83: 629-33. PMID 3456160 DOI: 10.1073/Pnas.83.3.629 |
0.446 |
|
| 1986 |
Kingston RE, Cowie A, Morimoto RI, Gwinn KA. Binding of polyomavirus large T antigen to the human hsp70 promoter is not required for trans activation. Molecular and Cellular Biology. 6: 3180-90. PMID 3023966 DOI: 10.1128/mcb.6.9.3180-3190.1986 |
0.402 |
|
| 1986 |
Morimoto RI, Hunt C, Huang SY, Berg KL, Banerji SS. Organization, nucleotide sequence, and transcription of the chicken HSP70 gene. The Journal of Biological Chemistry. 261: 12692-9. PMID 3017985 |
0.795 |
|
| 1985 |
Hunt C, Morimoto RI. Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70. Proceedings of the National Academy of Sciences of the United States of America. 82: 6455-9. PMID 3931075 DOI: 10.1073/Pnas.82.19.6455 |
0.369 |
|
| 1985 |
Wu BJ, Morimoto RI. Transcription of the human hsp70 gene is induced by serum stimulation. Proceedings of the National Academy of Sciences of the United States of America. 82: 6070-4. PMID 3862119 DOI: 10.1073/Pnas.82.18.6070 |
0.409 |
|
| 1985 |
Wu B, Hunt C, Morimoto RI. Structure and expression of the human gene encoding major heat shock protein HSP70. Molecular and Cellular Biology. 5: 330-341. PMID 2858050 DOI: 10.1128/mcb.5.2.330-341.1985 |
0.481 |
|
| 1984 |
Banerji SS, Theodorakis NG, Morimoto RI. Heat shock-induced translational control of HSP70 and globin synthesis in chicken reticulocytes. Molecular and Cellular Biology. 4: 2437-48. PMID 6513924 DOI: 10.1128/mcb.4.11.2437-2448.1984 |
0.816 |
|
| 1984 |
Morimoto R, Fodor E. Cell-specific Expression of Heat Shock Proteins in Chicken Reticulocytes and Lymphocytes Journal of Cell Biology. 99: 1316-1323. PMID 6480695 DOI: 10.1083/Jcb.99.4.1316 |
0.517 |
|
| 1981 |
Holmgren R, Corces V, Morimoto R, Blackman R, Meselson M. Sequence homologies in the 5' regions of four Drosophila heat-shock genes. Proceedings of the National Academy of Sciences of the United States of America. 78: 3775-8. PMID 6791161 DOI: 10.1073/Pnas.78.6.3775 |
0.81 |
|
| 1981 |
Levens D, Morimoto R, Rabinowitz M. Mitochondrial transcription complex from Saccharomyces cerevisiae. Journal of Biological Chemistry. 256: 1466-1473. DOI: 10.1016/s0021-9258(19)69986-2 |
0.505 |
|
| 1980 |
Locker J, Morimoto R, Synenki RM, Rabinowitz M. Analysis of mitochondrial RNA in Saccharomyces cerevisiae. Current Genetics. 1: 163-72. PMID 24190840 DOI: 10.1007/Bf00446962 |
0.54 |
|
| 1980 |
Corces V, Holmgren R, Freund R, Morimoto R, Meselson M. Four heat shock proteins of Drosophila melanogaster coded within a 12-kilobase region in chromosome subdivision 67B Proceedings of the National Academy of Sciences of the United States of America. 77: 5390-5393. PMID 6254079 DOI: 10.1073/Pnas.77.9.5390 |
0.828 |
|
| 1979 |
Lewin AS, Morimoto R, Rabinowitz M. Stable heterogeneity of mitochondrial DNA in grande and petite strains of S. cerevisiae Plasmid. 2: 474-484. PMID 384424 DOI: 10.1016/0147-619X(79)90031-3 |
0.655 |
|
| 1979 |
Morimoto R, Rabinowitz M. Physical mapping of the yeast mitochondrial genome - Derivation of the fine structure and gene map of strain D273-10B and comparison with a strain (MH41-7B) differing in genome size Mgg Molecular &Amp; General Genetics. 170: 25-48. PMID 375015 DOI: 10.1007/Bf00268578 |
0.546 |
|
| 1979 |
Morimoto R, Rabinowitz M. Physical mapping of the Xba I, Hinc II, Bgl II, Xho I, Sst I, and Pvu II restriction endonuclease cleavage fragments of mitochondrial DNA of S. cerevisiae Mgg Molecular &Amp; General Genetics. 170: 11-23. PMID 375013 DOI: 10.1007/Bf00268577 |
0.546 |
|
| 1979 |
Morimoto R, Lewin A, Rabinowitz M. Physical mapping and characterization of the mitochondrial DNA and RNA sequences from mit- mutants defective in cytochrome oxidase peptide 1 (OXI 3). Molecular & General Genetics : Mgg. 170: 1-9. PMID 220509 DOI: 10.1007/Bf00268576 |
0.556 |
|
| 1979 |
Holmgren R, Livak K, Morimoto R, Freund R, Meselson M. Studies of cloned sequences from four Drosophila heat shock loci. Cell. 18: 1359-70. PMID 117907 DOI: 10.1016/0092-8674(79)90246-0 |
0.811 |
|
| 1978 |
Lewin A, Morimoto R, Rabinowitz M, Fukuhara H. Restriction enzyme analysis of mitochondrial DNAs of petite mutants of yeast: Classification of petites, and deletion mapping of mitochondrial genes Mgg Molecular &Amp; General Genetics. 163: 257-275. PMID 355853 DOI: 10.1007/Bf00271955 |
0.546 |
|
| 1978 |
Morimoto R, Merten S, Lewin A, Martin NC, Rabinowitz M. Physical mapping of genes on yeast mitochondrial DNA: localization of antibiotic resistance loci, and rRNA and tRNA genes. Molecular & General Genetics : Mgg. 163: 241-55. PMID 355852 DOI: 10.1007/Bf00271954 |
0.663 |
|
| 1977 |
Morimoto R, Lewin A, Rabinowitz M. Restriction cleavage map of mitochonrial DNA from the yeast Saccharomyces cerevisiae. Nucleic Acids Research. 4: 2331-51. PMID 333388 DOI: 10.1093/Nar/4.7.2331 |
0.652 |
|
| 1975 |
Morimoto R, Lewin A, Hsu HJ, Rabinowitz M, Fukuhara H. Restriction endonuclease analysis of mitochondrial DNA from grande and genetically characterized cytoplasmic petite clones of Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 72: 3868-3872. PMID 1105566 DOI: 10.1073/Pnas.72.10.3868 |
0.664 |
|
| Show low-probability matches. |