Year |
Citation |
Score |
2023 |
Xu X, Herdendorf TJ, Duan H, Rohlik DL, Roy S, Zhou H, Alkhateeb H, Khandelwal S, Zhou Q, Li P, Arepally GM, Walker JK, Garcia BL, Geisbrecht BV. Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs. Journal of Immunology (Baltimore, Md. : 1950). PMID 38149922 DOI: 10.4049/jimmunol.2300630 |
0.608 |
|
2023 |
Roy S, Booth CE, Powell-Pierce AD, Schulz AM, Skare JT, Garcia BL. Conformational dynamics of complement protease C1r inhibitor proteins from Lyme disease- and relapsing fever-causing spirochetes. The Journal of Biological Chemistry. 104972. PMID 37380082 DOI: 10.1016/j.jbc.2023.104972 |
0.392 |
|
2023 |
Roy S, Booth CE, Powell-Pierce AD, Schulz AM, Skare JT, Garcia BL. "Conformational dynamics of C1r inhibitor proteins from Lyme disease and relapsing fever spirochetes". Biorxiv : the Preprint Server For Biology. PMID 36909632 DOI: 10.1101/2023.03.01.530473 |
0.383 |
|
2022 |
Garrigues RJ, Thomas S, Leong JM, Garcia BL. Outer surface lipoproteins from the Lyme disease spirochete exploit the molecular switch mechanism of the complement protease C1s. The Journal of Biological Chemistry. 102557. PMID 36183830 DOI: 10.1016/j.jbc.2022.102557 |
0.424 |
|
2022 |
Zhang Y, Vontz AJ, Kallenberger EM, Xu X, Ploscariu NT, Ramyar KX, Garcia BL, Ghebrehiwet B, Geisbrecht BV. gC1qR/C1qBP/HABP-1: Structural Analysis of the Trimeric Core Region, Interactions With a Novel Panel of Monoclonal Antibodies, and Their Influence on Binding to FXII. Frontiers in Immunology. 13: 887742. PMID 35865516 DOI: 10.3389/fimmu.2022.887742 |
0.642 |
|
2022 |
Booth CE, Powell-Pierce AD, Skare JT, Garcia BL. FbpA and FbpB Are Immunomodulatory Outer Surface Lipoproteins With Distinct Structures and Functions. Frontiers in Immunology. 13: 886733. PMID 35693799 DOI: 10.3389/fimmu.2022.886733 |
0.382 |
|
2021 |
Garrigues RJ, Powell-Pierce AD, Hammel M, Skare JT, Garcia BL. A Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes. Journal of Immunology (Baltimore, Md. : 1950). 207: 2856-2867. PMID 34759015 DOI: 10.4049/jimmunol.2100815 |
0.382 |
|
2020 |
Rushing BR, Rohlik DL, Roy S, Skaff DA, Garcia BL. Targeting the Initiator Protease of the Classical Pathway of Complement Using Fragment-Based Drug Discovery. Molecules (Basel, Switzerland). 25. PMID 32899120 DOI: 10.3390/Molecules25174016 |
0.429 |
|
2020 |
Skare JT, Garcia BL. Complement Evasion by Lyme Disease Spirochetes. Trends in Microbiology. PMID 32482556 DOI: 10.1016/J.Tim.2020.05.004 |
0.397 |
|
2019 |
Pickering AC, Vitry P, Prystopiuk V, Garcia B, Hook M, Schoenebeck J, Geoghegan JA, Dufrêne YF, Fitzgerald JR. Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion. Plos Pathogens. 15: e1007816. PMID 31216354 DOI: 10.1371/Journal.Ppat.1007816 |
0.483 |
|
2019 |
Xie J, Zhi H, Garrigues RJ, Keightley A, Garcia BL, Skare JT. Structural determination of the complement inhibitory domain of Borrelia burgdorferi BBK32 provides insight into classical pathway complement evasion by lyme disease spirochetes. Plos Pathogens. 15: e1007659. PMID 30897158 DOI: 10.1371/Journal.Ppat.1007659 |
0.468 |
|
2018 |
Eng L, Garcia BL, Geisbrecht BV, Hanning A. Quantitative monitoring of two simultaneously binding species using Label-Enhanced surface plasmon resonance. Biochemical and Biophysical Research Communications. PMID 29427666 DOI: 10.1016/J.Bbrc.2018.02.040 |
0.609 |
|
2018 |
de Jong NWM, Vrieling M, Garcia BL, Koop G, Brettmann M, Aerts PC, Ruyken M, van Strijp JAG, Holmes M, Harrison EM, Geisbrecht BV, Rooijakkers SHM. Identification of a Staphylococcal Complement Inhibitor with broad host specificity in equid S. aureus strains. The Journal of Biological Chemistry. PMID 29414776 DOI: 10.1074/Jbc.Ra117.000599 |
0.651 |
|
2018 |
de Jong NWM, Ploscariu NT, Ramyar KX, Garcia BL, Herrera AI, Prakash O, Katz BB, Leidal KG, Nauseef WM, van Kessel KPM, van Strijp JAG, Geisbrecht BV. A Structurally Dynamic N-terminal Region Drives Function of the Staphylococcal Peroxidase Inhibitor (SPIN). The Journal of Biological Chemistry. PMID 29306874 DOI: 10.1074/Jbc.Ra117.000134 |
0.599 |
|
2018 |
Garcia B, Skare J, Xie J, Zhi H. Molecular mechanisms of classical pathway complement evasion by Borrelia spp. Molecular Immunology. 102: 153. DOI: 10.1016/J.Molimm.2018.06.075 |
0.306 |
|
2017 |
de Jong NWM, Ramyar KX, Guerra FE, Nijland R, Fevre C, Voyich JM, McCarthy AJ, Garcia BL, van Kessel KPM, van Strijp JAG, Geisbrecht BV, Haas PA. Immune evasion by a staphylococcal inhibitor of myeloperoxidase. Proceedings of the National Academy of Sciences of the United States of America. PMID 28808028 DOI: 10.1073/Pnas.1707032114 |
0.645 |
|
2017 |
Ye Z, Needham PG, Estabrooks SK, Whitaker SK, Garcia BL, Misra S, Brodsky JL, Camacho CJ. Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Scientific Reports. 7: 1789. PMID 28496195 DOI: 10.1038/S41598-017-01880-4 |
0.407 |
|
2017 |
Garcia BL, Skaff DA, Chatterjee A, Hanning A, Walker JK, Wyckoff GJ, Geisbrecht BV. Identification of C3b-Binding Small-Molecule Complement Inhibitors Using Cheminformatics. Journal of Immunology (Baltimore, Md. : 1950). PMID 28298523 DOI: 10.4049/Jimmunol.1601932 |
0.683 |
|
2016 |
Garcia BL, Zwarthoff SA, Rooijakkers SH, Geisbrecht BV. Novel Evasion Mechanisms of the Classical Complement Pathway. Journal of Immunology (Baltimore, Md. : 1950). 197: 2051-60. PMID 27591336 DOI: 10.4049/Jimmunol.1600863 |
0.668 |
|
2016 |
Liang X, Garcia BL, Visai L, Prabhakaran S, Meenan NA, Potts JR, Humphries MJ, Höök M. Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs. Plos One. 11: e0159118. PMID 27434228 DOI: 10.1371/Journal.Pone.0159118 |
0.455 |
|
2016 |
Garcia BL, Zhi H, Wager B, Höök M, Skare JT. Borrelia burgdorferi BBK32 Inhibits the Classical Pathway by Blocking Activation of the C1 Complement Complex. Plos Pathogens. 12: e1005404. PMID 26808924 DOI: 10.1371/Journal.Ppat.1005404 |
0.549 |
|
2015 |
Takahashi D, Garcia BL, Kanost MR. Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects. Proceedings of the National Academy of Sciences of the United States of America. 112: 13856-61. PMID 26504233 DOI: 10.1073/Pnas.1517236112 |
0.448 |
|
2015 |
Georgoutsou-Spyridonos M, Ricklin D, Pratsinis H, Perivolioti E, Pirmettis I, Garcia BL, Geisbrecht BV, Foukas PG, Lambris JD, Mastellos DC, Sfyroera G. Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb. Journal of Immunology (Baltimore, Md. : 1950). 195: 3946-58. PMID 26342032 DOI: 10.4049/Jimmunol.1500966 |
0.683 |
|
2015 |
Summers BJ, Garcia BL, Woehl JL, Ramyar KX, Yao X, Geisbrecht BV. Identification of peptidic inhibitors of the alternative complement pathway based on Staphylococcus aureus SCIN proteins. Molecular Immunology. PMID 26052070 DOI: 10.1016/J.Molimm.2015.05.012 |
0.699 |
|
2014 |
Woehl JL, Stapels DA, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SH, Geisbrecht BV. The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase. Journal of Immunology (Baltimore, Md. : 1950). 193: 6161-71. PMID 25381436 DOI: 10.4049/Jimmunol.1401600 |
0.711 |
|
2013 |
Garcia BL, Summers BJ, Ramyar KX, Tzekou A, Lin Z, Ricklin D, Lambris JD, Laity JH, Geisbrecht BV. A structurally dynamic N-terminal helix is a key functional determinant in staphylococcal complement inhibitor (SCIN) proteins. The Journal of Biological Chemistry. 288: 2870-81. PMID 23233676 DOI: 10.1074/Jbc.M112.426858 |
0.719 |
|
2013 |
Garcia B, Laity J. Backbone 1H, 13C, and 15N Chemical Shift Assignments for Staphylococcal Complement Inhibitor SCIN-A Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.13018/Bmr18772 |
0.333 |
|
2012 |
Bannantine JP, Lingle CK, Stabel JR, Ramyar KX, Garcia BL, Raeber AJ, Schacher P, Kapur V, Geisbrecht BV. MAP1272c encodes an NlpC/P60 protein, an antigen detected in cattle with Johne's disease. Clinical and Vaccine Immunology : Cvi. 19: 1083-92. PMID 22593240 DOI: 10.1128/Cvi.00195-12 |
0.635 |
|
2012 |
Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV. Diversity in the C3b [corrected] contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family. The Journal of Biological Chemistry. 287: 628-40. PMID 22086928 DOI: 10.1074/Jbc.M111.298984 |
0.699 |
|
2012 |
Garcia BL, Ramyar KX, Ricklin D, Lambris JD, Geisbrecht BV. Advances in understanding the structure, function, and mechanism of the SCIN and Efb families of Staphylococcal immune evasion proteins. Advances in Experimental Medicine and Biology. 946: 113-33. PMID 21948365 DOI: 10.1007/978-1-4614-0106-3_7 |
0.665 |
|
2012 |
Garcia BL, Summers BJ, Lin Z, Ramyar KX, Ricklin D, Kamath DV, Fu ZQ, Lambris JD, Geisbrecht BV. Diversity in the C3b contact residues and tertiary structures of the staphylococcal complement inhibitor (SCIN) protein family (Journal of Biological Chemistry (2012) 287, (628-640)) Journal of Biological Chemistry. 287: 9329. DOI: 10.1074/jbc.A111.298984 |
0.599 |
|
2010 |
Chen H, Ricklin D, Hammel M, Garcia BL, McWhorter WJ, Sfyroera G, Wu YQ, Tzekou A, Li S, Geisbrecht BV, Woods VL, Lambris JD. Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proceedings of the National Academy of Sciences of the United States of America. 107: 17621-6. PMID 20876141 DOI: 10.1073/Pnas.1003750107 |
0.736 |
|
2010 |
Garcia BL, Ramyar KX, Tzekou A, Ricklin D, McWhorter WJ, Lambris JD, Geisbrecht BV. Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. Journal of Molecular Biology. 402: 17-29. PMID 20654625 DOI: 10.1016/J.Jmb.2010.07.029 |
0.721 |
|
2010 |
Jongerius I, Garcia BL, Geisbrecht BV, van Strijp JA, Rooijakkers SH. Convertase inhibitory properties of Staphylococcal extracellular complement-binding protein. The Journal of Biological Chemistry. 285: 14973-9. PMID 20304920 DOI: 10.1074/Jbc.M109.091975 |
0.689 |
|
2010 |
Garcia BL, Tzekou A, Ricklin D, Ramyar KX, McWhorter WJ, Geisbrecht BV, Lambris JD. Molecular basis for complement recognition and inhibition by staphylococcal complement inhibitors Molecular Immunology. 47: 2245-2245. DOI: 10.1016/J.Molimm.2010.05.145 |
0.628 |
|
2010 |
Ricklin D, Chen H, Hammel M, Garcia BL, McWhorter WJ, Sfyroera G, Wu Y, Tzekou A, Li S, Geisbrecht BV. Allosteric inhibition of complement function by the Staphylococcal immune evasion protein Efb Molecular Immunology. 47: 2244-2245. DOI: 10.1016/J.Molimm.2010.05.144 |
0.673 |
|
2009 |
Ricklin D, Tzekou A, Garcia BL, Hammel M, McWhorter WJ, Sfyroera G, Wu YQ, Holers VM, Herbert AP, Barlow PN, Geisbrecht BV, Lambris JD. A molecular insight into complement evasion by the staphylococcal complement inhibitor protein family. Journal of Immunology (Baltimore, Md. : 1950). 183: 2565-74. PMID 19625656 DOI: 10.4049/Jimmunol.0901443 |
0.715 |
|
2009 |
Garcia BL, Tzekou A, Ramyar KX, McWhorter WJ, Ricklin D, Lambris JD, Geisbrecht BV. Crystallization of human complement component C3b in the presence of a staphylococcal complement-inhibitor protein (SCIN). Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 482-5. PMID 19407382 DOI: 10.1107/S174430910901207X |
0.663 |
|
2008 |
Ricklin D, Ricklin-Lichtsteiner SK, Sfyroera G, Chen H, Tzekou A, Magotti P, Wu Y, Garcia BL, McWorther WJ, Haspel N, Kavraki LE, Geisbrecht BV, Lambris JD. Novel insights into target specificities and molecular mechanisms for two potent complement evasion proteins from Staphylococcus aureus Molecular Immunology. 45: 4114-4115. DOI: 10.1016/J.Molimm.2008.08.058 |
0.643 |
|
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