| Year |
Citation |
Score |
| 2024 |
Mate de Gerando A, Khasnavis A, Welikovitch LA, Bhavsar H, Glynn C, Quittot N, Perbet R, Hyman BT. Aqueous extractable nonfibrillar and sarkosyl extractable fibrillar Alzheimer's disease tau seeds have distinct properties. Acta Neuropathologica Communications. 12: 145. PMID 39252090 DOI: 10.1186/s40478-024-01849-1 |
0.81 |
|
| 2024 |
Chung DC, Deng X, Yalamanchili HK, Revelli JP, Han AL, Tadros B, Richman R, Dias M, Naini FA, Boeynaems S, Hyman BT, Zoghbi HY. The big tau splice isoform resists Alzheimer's-related pathological changes. Biorxiv : the Preprint Server For Biology. PMID 39211086 DOI: 10.1101/2024.07.30.605685 |
0.406 |
|
| 2024 |
Jackson RJ, Melloni A, Fykstra DP, Serrano-Pozo A, Shinobu L, Hyman BT. Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription. Acta Neuropathologica Communications. 12: 132. PMID 39138580 DOI: 10.1186/s40478-024-01844-6 |
0.402 |
|
| 2024 |
Zwang TJ, Sastre ED, Wolf N, Ruiz-Uribe N, Woost B, Hoglund Z, Fan Z, Bailey J, Nfor L, Buée L, Nilsson KPR, Hyman BT, Bennett RE. Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology. Cell Reports. 43: 114574. PMID 39096489 DOI: 10.1016/j.celrep.2024.114574 |
0.736 |
|
| 2024 |
Perbet R, Mate de Gerando A, Glynn C, Donahue C, Gaona A, Taddei RN, Gomez-Isla T, Lathuiliere A, Hyman BT. In situ seeding assay: A novel technique for direct tissue localization of bioactive tau. Journal of Neuropathology and Experimental Neurology. PMID 38917443 DOI: 10.1093/jnen/nlae059 |
0.397 |
|
| 2024 |
Jackson RJ, Hyman BT, Serrano-Pozo A. Multifaceted roles of APOE in Alzheimer disease. Nature Reviews. Neurology. PMID 38906999 DOI: 10.1038/s41582-024-00988-2 |
0.36 |
|
| 2024 |
Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, Williams-Ramirez J, Herisse R, Deden-Binder LJ, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, ... ... Hyman BT, et al. Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology. Elife. 12. PMID 38896568 DOI: 10.7554/eLife.91398 |
0.718 |
|
| 2024 |
Hoglund Z, Ruiz-Uribe N, Del Sastre E, Woost B, Bader E, Bailey J, Hyman BT, Zwang T, Bennett RE. Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease. Acta Neuropathologica. 147: 101. PMID 38884806 DOI: 10.1007/s00401-024-02751-9 |
0.706 |
|
| 2024 |
Oakley DH, Chung M, Abrha S, Hyman BT, Frosch MP. β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains. Journal of Neuropathology and Experimental Neurology. PMID 38874454 DOI: 10.1093/jnen/nlae053 |
0.791 |
|
| 2024 |
Cooper JM, Lathuiliere A, Su EJ, Song Y, Torrente D, Jo Y, Weinrich N, Sales JD, Migliorini M, Sisson TH, Lawrence DA, Hyman BT, Strickland DK. SORL1 is a receptor for tau that promotes tau seeding. The Journal of Biological Chemistry. 107313. PMID 38657864 DOI: 10.1016/j.jbc.2024.107313 |
0.391 |
|
| 2024 |
Jaisa-Aad M, Muñoz-Castro C, Healey MA, Hyman BT, Serrano-Pozo A. Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias. Acta Neuropathologica. 147: 66. PMID 38568475 DOI: 10.1007/s00401-024-02712-2 |
0.818 |
|
| 2024 |
Wachter A, Woodbury ME, Lombardo S, Abdourahman A, Wuest C, McGlame E, Pastika T, Tamm J, Romanul N, Yanamandra K, Bennett R, Lin G, Kwon T, Liao F, Klein C, ... ... Hyman BT, et al. Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau. Acta Neuropathologica. 147: 65. PMID 38557897 DOI: 10.1007/s00401-024-02704-2 |
0.763 |
|
| 2024 |
Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Hajizadeh S, Kreuzer J, Morris R, Melloni A, Nakajima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Nishtar MA, ... ... Hyman BT, et al. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 38504517 DOI: 10.1016/j.ymthe.2024.03.024 |
0.408 |
|
| 2024 |
Marques C, Held A, Dorfman K, Sung J, Song C, Kavuturu AS, Aguilar C, Russo T, Oakley DH, Albers MW, Hyman BT, Petrucelli L, Lagier-Tourenne C, Wainger BJ. Neuronal STING activation in amyotrophic lateral sclerosis and frontotemporal dementia. Acta Neuropathologica. 147: 56. PMID 38478117 DOI: 10.1007/s00401-024-02688-z |
0.671 |
|
| 2024 |
Hoglund Z, Ruiz-Uribe N, Del Sastre E, Woost B, Bailey J, Hyman BT, Zwang T, Bennett RE. Brain Vasculature Accumulates Tau and Is Spatially Related to Tau Tangle Pathology in Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 38328111 DOI: 10.1101/2024.01.27.577088 |
0.706 |
|
| 2024 |
Noori A, Jayakumar R, Moturi V, Li Z, Liu R, Serrano-Pozo A, Hyman BT, Das S. Alzheimer DataLENS: An Open Data Analytics Portal for Alzheimer's Disease Research. Journal of Alzheimer's Disease : Jad. PMID 38306039 DOI: 10.3233/JAD-230884 |
0.327 |
|
| 2024 |
Greenberg ABW, Mekbib KY, Mehta NH, Kiziltug E, Duy PQ, Smith HR, Junkkari A, Leinonen V, Hyman BT, Chan D, Curry WT, Arnold SE, Barker Ii FG, Frosch MP, Kahle KT. Utility of cortical tissue analysis in normal pressure hydrocephalus. Cerebral Cortex (New York, N.Y. : 1991). PMID 38275188 DOI: 10.1093/cercor/bhae001 |
0.429 |
|
| 2024 |
Agarwal K, Backler W, Bayram E, Bloom L, Boeve BF, Cha JH, Denslow M, Ferman TJ, Galasko D, Galvin JE, Gomperts SN, Irizarry MC, Kantarci K, Kaushik H, Kietlinski M, ... ... Hyman BT, et al. Lewy body dementia: Overcoming barriers and identifying solutions. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38265159 DOI: 10.1002/alz.13674 |
0.681 |
|
| 2024 |
Kumar M, Quittot N, Dujardin S, Schlaffner CN, Viode A, Wiedmer A, Beerepoot P, Chun JE, Glynn C, Fernandes AR, Donahue C, Steen JA, Hyman BT. Alzheimer proteopathic tau seeds are biochemically a forme fruste of mature paired helical filaments. Brain : a Journal of Neurology. PMID 38236720 DOI: 10.1093/brain/awad378 |
0.73 |
|
| 2024 |
Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, Tcw J, Schellenberg GD, Tsai LH, Herz J, Holtzman DM. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of Neurology. PMID 38180638 DOI: 10.1002/ana.26864 |
0.342 |
|
| 2024 |
Agra Almeida Quadros AR, Li Z, Wang X, Ndayambaje IS, Aryal S, Ramesh N, Nolan M, Jayakumar R, Han Y, Stillman H, Aguilar C, Wheeler HJ, Connors T, Lopez-Erauskin J, Baughn MW, ... ... Hyman BT, et al. Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer's disease. Acta Neuropathologica. 147: 9. PMID 38175301 DOI: 10.1007/s00401-023-02655-0 |
0.733 |
|
| 2023 |
Olsen A, Locascio J, Tuncali I, Laroussi N, Abatzis E, Kamenskaya P, Kuras Y, Yi T, Videnovic A, Hayes M, Ho G, Paulson J, Khurana V, Herrington T, Hyman B, et al. Health phenome of Parkinson's patients reveals prominent mood-sleep cluster. Research Square. PMID 38196602 DOI: 10.21203/rs.3.rs-3683455/v1 |
0.578 |
|
| 2023 |
Glynn C, Chun JE, Donahue CC, Nadler MJS, Fan Z, Hyman BT. Reconstitution of the Alzheimer's Disease Tau Core Structure from Recombinant Tau Yields Variable Quaternary Structures as Seen by Negative Stain and Cryo-EM. Biochemistry. 63: 194-201. PMID 38154792 DOI: 10.1021/acs.biochem.3c00425 |
0.386 |
|
| 2023 |
Lee H, Fu JF, Gaudet K, Bryant AG, Price JC, Bennett RE, Johnson KA, Hyman BT, Hedden T, Salat DH, Yen YF, Huang SY. Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X231216144. PMID 38000018 DOI: 10.1177/0271678X231216144 |
0.668 |
|
| 2023 |
Greenberg ABW, Mehta NH, Mekbib KY, Kiziltug E, Smith HR, Hyman BT, Chan D, Curry WT, Arnold SE, Frosch MP, Duy PQ, Kahle KT. Cases of familial idiopathic normal pressure hydrocephalus implicate genetic factors in disease pathogenesis. Cerebral Cortex (New York, N.Y. : 1991). PMID 37814356 DOI: 10.1093/cercor/bhad374 |
0.423 |
|
| 2023 |
Mate de Gerando A, Quittot N, Frosch MP, Hyman BT. Reply: Soluble oligomers or insoluble fibrils? Acta Neuropathologica. 146: 863-866. PMID 37733036 DOI: 10.1007/s00401-023-02634-5 |
0.453 |
|
| 2023 |
Petrozziello T, Huntress SS, Castillo-Torres AL, Quinn JP, Connors TR, Auger CA, Mills AN, Kim SE, Liu S, Mahmood F, Boudi A, Wu M, Sapp E, Kivisäkk P, Sunderesh SR, ... ... Hyman BT, et al. Age-Dependent Increase in Tau Phosphorylation at Serine 396 in Huntington's Disease Prefrontal Cortex. Journal of Huntington's Disease. PMID 37694372 DOI: 10.3233/JHD-230588 |
0.32 |
|
| 2023 |
Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Melloni A, Nakajima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Holtzman DM, Davidson BL, Hyman BT. APOE2 gene therapy reduces amyloid deposition, and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease. Biorxiv : the Preprint Server For Biology. PMID 37645718 DOI: 10.1101/2023.08.14.552850 |
0.406 |
|
| 2023 |
Davies C, Tulloch J, Yip E, Currie L, Colom-Cadena M, Wegmann S, Hyman BT, Wilkins L, Hooley M, Tzioras M, Spires-Jones TL. Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model. Brain and Neuroscience Advances. 7: 23982128231191046. PMID 37600228 DOI: 10.1177/23982128231191046 |
0.836 |
|
| 2023 |
Lathuiliere A, Jo Y, Perbet R, Donahue C, Commins C, Quittot N, Fan Z, Bennett RE, Hyman BT. Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells. Molecular Neurodegeneration. 18: 53. PMID 37553663 DOI: 10.1186/s13024-023-00643-2 |
0.681 |
|
| 2023 |
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Hyman BT, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311 |
0.715 |
|
| 2023 |
Das S, Li Z, Wachter A, Alla S, Noori A, Abdourahman A, Tamm JA, Woodbury ME, Talanian RV, Biber K, Karran EH, Hyman BT, Serrano-Pozo A. Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 37461318 DOI: 10.1002/alz.13387 |
0.42 |
|
| 2023 |
Mate De Gerando A, Welikovitch LA, Khasnavis A, Commins C, Glynn C, Chun JE, Perbet R, Hyman BT. Tau seeding and spreading in vivo is supported by both AD-derived fibrillar and oligomeric tau. Acta Neuropathologica. 146: 191-210. PMID 37341831 DOI: 10.1007/s00401-023-02600-1 |
0.815 |
|
| 2023 |
Petrozziello T, Huntress SS, Castillo-Torres AL, Quinn JP, Connors TR, Auger CA, Mills AN, Kim SE, Liu S, Mahmood F, Boudi A, Wu M, Sapp E, Kivisäkk P, Sunderesh SR, ... ... Hyman BT, et al. Age-dependent increase in tau phosphorylation at serine 396 in Huntington's disease pre-frontal cortex. Medrxiv : the Preprint Server For Health Sciences. PMID 37333415 DOI: 10.1101/2023.06.03.23290851 |
0.326 |
|
| 2023 |
Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, William-Ramirez J, Herisse R, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, Connors TR, ... ... Hyman BT, et al. 3D analysis of dissection photographs with surface scanning and machine learning for quantitative neuropathology. Biorxiv : the Preprint Server For Biology. PMID 37333251 DOI: 10.1101/2023.06.08.544050 |
0.713 |
|
| 2023 |
Zwang TJ, Woost B, Bailey J, Hoglund Z, Richardson DS, Bennett RE, Hyman BT. Spatial characterization of tangle-bearing neurons and ghost tangles in the human inferior temporal gyrus with three-dimensional imaging. Brain Communications. 5: fcad130. PMID 37324243 DOI: 10.1093/braincomms/fcad130 |
0.658 |
|
| 2023 |
Bryant A, Li Z, Jayakumar R, Serrano-Pozo A, Woost B, Hu M, Woodbury ME, Wachter A, Lin G, Kwon T, Talanian RV, Biber K, Karran EH, Hyman BT, Das S, et al. Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 37208174 DOI: 10.1523/JNEUROSCI.0237-23.2023 |
0.674 |
|
| 2023 |
Mate de Gerando A, Welikovitch LA, Khasnavis A, Commins C, Glynn C, Perbet R, Hyman BT. Tau seeding and spreading in vivo is supported by both fibrillar and oligomeric tau. Biorxiv : the Preprint Server For Biology. PMID 37034629 DOI: 10.1101/2023.03.28.534418 |
0.808 |
|
| 2023 |
Das S, Li Z, Wachter A, Alla S, Noori A, Abdourahman A, Tamm JA, Woodbury ME, Talanian RV, Biber K, Karran EH, Hyman BT, Serrano-Pozo A. Distinct Transcriptomic Responses to Aβ plaques, Neurofibrillary Tangles, and in Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 36993332 DOI: 10.1101/2023.03.20.533303 |
0.415 |
|
| 2023 |
Kivisäkk P, Carlyle BC, Sweeney T, Trombetta BA, LaCasse K, El-Mufti L, Tuncali I, Chibnik LB, Das S, Scherzer CR, Johnson KA, Dickerson BC, Gomez-Isla T, Blacker D, Oakley DH, ... ... Hyman BT, et al. Plasma biomarkers for diagnosis of Alzheimer's disease and prediction of cognitive decline in individuals with mild cognitive impairment. Frontiers in Neurology. 14: 1069411. PMID 36937522 DOI: 10.3389/fneur.2023.1069411 |
0.752 |
|
| 2023 |
Bryant A, Li Z, Jayakumar R, Serrano-Pozo A, Woost B, Hu M, Woodbury ME, Wachter A, Lin G, Kwon T, Talanian RV, Biber K, Karran EH, Hyman BT, Das S, et al. Endothelial Cells are Heterogeneous in Different Brain Regions and are Dramatically Altered in Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 36824974 DOI: 10.1101/2023.02.16.528825 |
0.68 |
|
| 2023 |
Welikovitch LA, Dujardin S, Dunn AR, Fernandes AR, Khasnavis A, Chibnik LB, Kaczorowski CC, Hyman BT. Rate of tau propagation is a heritable disease trait in genetically diverse mouse strains. Iscience. 26: 105983. PMID 36756365 DOI: 10.1016/j.isci.2023.105983 |
0.828 |
|
| 2023 |
Wenger K, Viode A, Schlaffner CN, van Zalm P, Cheng L, Dellovade T, Langlois X, Bannon A, Chang R, Connors TR, Oakley D, Renard B, Rappsilber J, Hyman B, Steen H, et al. Common mouse models of tauopathy reflect early but not late human disease. Molecular Neurodegeneration. 18: 10. PMID 36732784 DOI: 10.1186/s13024-023-00601-y |
0.722 |
|
| 2023 |
Zwang TJ, Bennett RE, Lysandrou M, Woost B, Zhang A, Lieber CM, Richardson DS, Hyman BT. Tissue libraries enable rapid determination of conditions that preserve antibody labeling in cleared mouse and human tissue. Elife. 12. PMID 36656755 DOI: 10.7554/eLife.84112 |
0.558 |
|
| 2022 |
Dickson JR, Frosch MP, Hyman BT. Altered localization of nucleoporin 98 in primary tauopathies. Brain Communications. 5: fcac334. PMID 36601621 DOI: 10.1093/braincomms/fcac334 |
0.565 |
|
| 2022 |
Muñoz-Castro C, Noori A, Hyman BT, Serrano-Pozo A. Cyclic Multiplex Fluorescent Immunohistochemistry Protocol to Phenotype Glial Cells in Formalin-Fixed Paraffin-Embedded Human Brain Sections. Methods in Molecular Biology (Clifton, N.J.). 2593: 283-305. PMID 36513939 DOI: 10.1007/978-1-0716-2811-9_19 |
0.792 |
|
| 2022 |
Hyman B. All the Tau We Cannot See. Annual Review of Medicine. PMID 36378913 DOI: 10.1146/annurev-med-042921-023749 |
0.43 |
|
| 2022 |
Sommerer Y, Ohlei O, Dobricic V, Oakley DH, Wesse T, Sedghpour Sabet S, Demuth I, Franke A, Hyman BT, Lill CM, Bertram L. A correlation map of genome-wide DNA methylation patterns between paired human brain and buccal samples. Clinical Epigenetics. 14: 139. PMID 36320053 DOI: 10.1186/s13148-022-01357-w |
0.647 |
|
| 2022 |
Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, ... ... Hyman BT, et al. Author Correction: [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nature Communications. 13: 5833. PMID 36192402 DOI: 10.1038/s41467-022-33668-0 |
0.478 |
|
| 2022 |
Pascoal TA, Chamoun M, Lax E, Wey HY, Shin M, Ng KP, Kang MS, Mathotaarachchi S, Benedet AL, Therriault J, Lussier FZ, Schroeder FA, DuBois JM, Hightower BG, Gilbert TM, ... ... Hyman BT, et al. [C]Martinostat PET analysis reveals reduced HDAC I availability in Alzheimer's disease. Nature Communications. 13: 4171. PMID 35853847 DOI: 10.1038/s41467-022-30653-5 |
0.56 |
|
| 2022 |
Bashit AA, Nepal P, Connors T, Oakley DH, Hyman BT, Yang L, Makowski L. Mapping the Spatial Distribution of Fibrillar Polymorphs in Human Brain Tissue. Frontiers in Neuroscience. 16: 909542. PMID 35720706 DOI: 10.3389/fnins.2022.909542 |
0.715 |
|
| 2022 |
Miller MB, Huang AY, Kim J, Zhou Z, Kirkham SL, Maury EA, Ziegenfuss JS, Reed HC, Neil JE, Rento L, Ryu SC, Ma CC, Luquette LJ, Ames HM, Oakley DH, ... ... Hyman BT, et al. Somatic genomic changes in single Alzheimer's disease neurons. Nature. PMID 35444284 DOI: 10.1038/s41586-022-04640-1 |
0.772 |
|
| 2022 |
Dujardin S, Fernandes A, Bannon R, Commins C, De Los Santos M, Kamath TV, Hayashi M, Hyman BT. Tau propagation is dependent on the genetic background of mouse strains. Brain Communications. 4: fcac048. PMID 35350555 DOI: 10.1093/braincomms/fcac048 |
0.752 |
|
| 2022 |
Weng J, Muti IH, Zhong AB, Kivisäkk P, Hyman BT, Arnold SE, Cheng LL. A Nuclear Magnetic Resonance Spectroscopy Method in Characterization of Blood Metabolomics for Alzheimer's Disease. Metabolites. 12. PMID 35208255 DOI: 10.3390/metabo12020181 |
0.302 |
|
| 2022 |
Muñoz-Castro C, Noori A, Magdamo CG, Li Z, Marks JD, Frosch MP, Das S, Hyman BT, Serrano-Pozo A. Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer's disease. Journal of Neuroinflammation. 19: 30. PMID 35109872 DOI: 10.1186/s12974-022-02383-4 |
0.834 |
|
| 2021 |
Serrano-Pozo A, Li Z, Noori A, Nguyen HN, Mezlini A, Li L, Hudry E, Jackson RJ, Hyman BT, Das S. Effect of alleles on the glial transcriptome in normal aging and Alzheimer's disease. Nature Aging. 1: 919-931. PMID 36199750 DOI: 10.1038/s43587-021-00123-6 |
0.336 |
|
| 2021 |
Jackson RJ, Meltzer JC, Nguyen H, Commins C, Bennett RE, Hudry E, Hyman BT. APOE4 derived from astrocytes leads to blood-brain barrier impairment. Brain : a Journal of Neurology. PMID 34957486 DOI: 10.1093/brain/awab478 |
0.604 |
|
| 2021 |
Bryant AG, Manhard MK, Salat DH, Rosen BR, Hyman BT, Johnson KA, Huang S, Bennett RE, Yen YF. Heterogeneity of Tau Deposition and Microvascular Involvement in MCI and AD. Current Alzheimer Research. PMID 34825871 DOI: 10.2174/1567205018666211126113904 |
0.71 |
|
| 2021 |
Petrozziello T, Amaral AC, Dujardin S, Farhan SMK, Chan J, Trombetta BA, Kivisäkk P, Mills AN, Bordt EA, Kim SE, Dooley PM, Commins C, Connors TR, Oakley DH, Ghosal A, ... ... Hyman BT, et al. Novel genetic variants in MAPT and alterations in tau phosphorylation in amyotrophic lateral sclerosis post-mortem motor cortex and cerebrospinal fluid. Brain Pathology (Zurich, Switzerland). e13035. PMID 34779076 DOI: 10.1111/bpa.13035 |
0.804 |
|
| 2021 |
Petrozziello T, Bordt EA, Mills AN, Kim SE, Sapp E, Devlin BA, Obeng-Marnu AA, Farhan SMK, Amaral AC, Dujardin S, Dooley PM, Henstridge C, Oakley DH, Neueder A, Hyman BT, et al. Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. Molecular Neurobiology. PMID 34757590 DOI: 10.1007/s12035-021-02557-w |
0.791 |
|
| 2021 |
Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Hyman BT, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z |
0.593 |
|
| 2021 |
Meisl G, Hidari E, Allinson K, Rittman T, DeVos SL, Sanchez JS, Xu CK, Duff KE, Johnson KA, Rowe JB, Hyman BT, Knowles TPJ, Klenerman D. In vivo rate-determining steps of tau seed accumulation in Alzheimer's disease. Science Advances. 7: eabh1448. PMID 34714685 DOI: 10.1126/sciadv.abh1448 |
0.339 |
|
| 2021 |
Lee MJ, Wang C, Carroll MJ, Brubaker DK, Hyman BT, Lauffenburger DA. Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging. Frontiers in Neuroscience. 15: 727784. PMID 34658769 DOI: 10.3389/fnins.2021.727784 |
0.307 |
|
| 2021 |
Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, ... ... Hyman B, et al. Current directions in tau research: Highlights from Tau 2020. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34581500 DOI: 10.1002/alz.12452 |
0.538 |
|
| 2021 |
Fernandes AR, Dujardin S, Maté de Gérando A, Hyman BT, Frosch MP. Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. Journal of Neuropathology and Experimental Neurology. PMID 34498073 DOI: 10.1093/jnen/nlab087 |
0.768 |
|
| 2021 |
Devitt G, Crisford A, Rice W, Weismiller HA, Fan Z, Commins C, Hyman BT, Margittai M, Mahajan S, Mudher A. Conformational fingerprinting of tau variants and strains by Raman spectroscopy. Rsc Advances. 11: 8899-8915. PMID 34381596 DOI: 10.1039/d1ra00870f |
0.305 |
|
| 2021 |
de Navas LV, Noori A, Merrill E, Das S, Hyman BT, Serrano-Pozo A. Systematic review of human post-mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease. Neuropathology and Applied Neurobiology. PMID 34297416 DOI: 10.1111/nan.12753 |
0.303 |
|
| 2021 |
Rodriguez S, Sahin A, Schrank BR, Al-Lawati H, Costantino I, Benz E, Fard D, Albers AD, Cao L, Gomez AC, Evans K, Ratti E, Cudkowicz M, Frosch MP, Talkowski M, ... ... Hyman BT, et al. Genome-encoded cytoplasmic double-stranded RNAs, found in ALS-FTD brain, propagate neuronal loss. Science Translational Medicine. 13. PMID 34233951 DOI: 10.1126/scitranslmed.aaz4699 |
0.449 |
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| 2021 |
Kamath TV, Klickstein N, Commins C, Fernandes AR, Oakley DH, Frosch MP, Hyman BT, Dujardin S. Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases. Brain Communications. 3: fcab096. PMID 34222869 DOI: 10.1093/braincomms/fcab096 |
0.837 |
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| 2021 |
Kara E, Crimi A, Wiedmer A, Emmenegger M, Manzoni C, Bandres-Ciga S, D'Sa K, Reynolds RH, Botía JA, Losa M, Lysenko V, Carta M, Heinzer D, Avar M, Chincisan A, ... ... Hyman BT, et al. An integrated genomic approach to dissect the genetic landscape regulating the cell-to-cell transfer of α-synuclein. Cell Reports. 35: 109189. PMID 34107263 DOI: 10.1016/j.celrep.2021.109189 |
0.665 |
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| 2021 |
Dickson JR, Yoon H, Frosch MP, Hyman BT. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. Journal of Neuropathology and Experimental Neurology. PMID 33990839 DOI: 10.1093/jnen/nlab040 |
0.744 |
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| 2021 |
Knopman DS, Amieva H, Petersen RC, Chételat G, Holtzman DM, Hyman BT, Nixon RA, Jones DT. Alzheimer disease. Nature Reviews. Disease Primers. 7: 33. PMID 33986301 DOI: 10.1038/s41572-021-00269-y |
0.387 |
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| 2021 |
Madrasi K, Das R, Mohmmadabdul H, Lin L, Hyman BT, Lauffenburger DA, Albers MW, Rissman RA, Burke JM, Apgar JF, Wille L, Gruenbaum L, Hua F. Systematic in silico analysis of clinically tested drugs for reducing amyloid-beta plaque accumulation in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33938131 DOI: 10.1002/alz.12312 |
0.315 |
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| 2021 |
Cooper JM, Lathuiliere A, Migliorini M, Arai AL, Wani MM, Dujardin S, Muratoglu SC, Hyman BT, Strickland DK. Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism. The Journal of Biological Chemistry. 100715. PMID 33930462 DOI: 10.1016/j.jbc.2021.100715 |
0.762 |
|
| 2021 |
Oakley DH, Klickstein N, Commins C, Chung M, Dujardin S, Bennett RE, Hyman BT, Frosch MP. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33893219 DOI: 10.1523/JNEUROSCI.2590-20.2021 |
0.838 |
|
| 2021 |
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, ... ... Hyman BT, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238. PMID 33854069 DOI: 10.1038/s41467-021-22501-9 |
0.722 |
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| 2021 |
Lathuiliere A, Hyman BT. Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids. Frontiers in Neuroscience. 15: 654176. PMID 33828458 DOI: 10.3389/fnins.2021.654176 |
0.381 |
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| 2021 |
William CM, Stern MA, Pei X, Saqran L, Ramani M, Frosch MP, Hyman BT. Impairment of visual cortical plasticity by amyloid-beta species. Neurobiology of Disease. 154: 105344. PMID 33766652 DOI: 10.1016/j.nbd.2021.105344 |
0.571 |
|
| 2021 |
Wegmann S, DeVos SL, Zeitler B, Marlen K, Bennett RE, Perez-Rando M, MacKenzie D, Yu Q, Commins C, Bannon RN, Corjuc BT, Chase A, Diez L, Nguyen HB, Hinkley S, ... ... Hyman BT, et al. Persistent repression of tau in the brain using engineered zinc finger protein transcription factors. Science Advances. 7. PMID 33741591 DOI: 10.1126/sciadv.abe1611 |
0.815 |
|
| 2021 |
Litvinchuk A, Huynh TV, Shi Y, Jackson RJ, Finn MB, Manis M, Francis CM, Tran A, Sullivan PM, Ulrich JD, Hyman BT, Cole T, Holtzman DM. ApoE4 reduction with ASOs decreases neurodegeneration in a tauopathy model. Annals of Neurology. PMID 33550655 DOI: 10.1002/ana.26043 |
0.355 |
|
| 2021 |
Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, ... ... Hyman BT, et al. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 33514949 DOI: 10.1038/s41591-021-01251-7 |
0.831 |
|
| 2021 |
Serrano-Pozo A, Das S, Hyman BT. APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therapeutic approaches. The Lancet. Neurology. 20: 68-80. PMID 33340485 DOI: 10.1016/S1474-4422(20)30412-9 |
0.316 |
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| 2021 |
Lathuiliere A, Hyman BT. Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids Frontiers in Neuroscience. 15. DOI: 10.3389/fnins.2021.654176 |
0.358 |
|
| 2020 |
Noori A, Mezlini AM, Hyman BT, Serrano-Pozo A, Das S. Systematic review and meta-analysis of human Transcriptomics reveals Neuroinflammation, deficient energy metabolism, and Proteostasis failure across Neurodegeneration. Neurobiology of Disease. 105225. PMID 33347974 DOI: 10.1016/j.nbd.2020.105225 |
0.335 |
|
| 2020 |
Sepulveda-Falla D, Chavez-Gutierrez L, Portelius E, Vélez JI, Dujardin S, Barrera-Ocampo A, Dinkel F, Hagel C, Puig B, Mastronardi C, Lopera F, Hyman BT, Blennow K, Arcos-Burgos M, de Strooper B, et al. A multifactorial model of pathology for age of onset heterogeneity in familial Alzheimer's disease. Acta Neuropathologica. PMID 33319314 DOI: 10.1007/s00401-020-02249-0 |
0.77 |
|
| 2020 |
Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, ... ... Hyman BT, et al. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. PMID 33188775 DOI: 10.1016/j.cell.2020.10.029 |
0.784 |
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| 2020 |
Perez-Rando M, Dujardin S, Bennett RE, Commins C, Nibhanupudy T, Hyman BT. Synaptic and metabolic gene expression alterations in neurons that are recipients of proteopathic tau seeds. Acta Neuropathologica Communications. 8: 168. PMID 33076986 DOI: 10.1186/s40478-020-01049-7 |
0.809 |
|
| 2020 |
Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, ... ... Hyman BT, et al. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Jama Neurology. PMID 33074286 DOI: 10.1001/jamaneurol.2020.3536 |
0.536 |
|
| 2020 |
Bryant AG, Hu M, Carlyle BC, Arnold SE, Frosch MP, Das S, Hyman BT, Bennett RE. Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. Frontiers in Neurology. 11: 575953. PMID 33041998 DOI: 10.3389/Fneur.2020.575953 |
0.762 |
|
| 2020 |
Wurts A, Oakley DH, Hyman BT, Samsi S. Segmentation of Tau Stained Alzheimers Brain Tissue Using Convolutional Neural Networks. Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference. 2020: 1420-1423. PMID 33018256 DOI: 10.1109/EMBC44109.2020.9175832 |
0.702 |
|
| 2020 |
Asher DM, Belay E, Bigio E, Brandner S, Brubaker SA, Caughey B, Clark B, Damon I, Diamond M, Freund M, Hyman BT, Jucker M, Keene CD, Lieberman AP, Mackiewicz M, et al. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. Journal of Neuropathology and Experimental Neurology. PMID 33000167 DOI: 10.1093/jnen/nlaa109 |
0.477 |
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| 2020 |
Bennett RE, Hu M, Fernandes A, Perez-Rando M, Robbins A, Kamath T, Dujardin S, Hyman BT. Tau reduction in aged mice does not impact Microangiopathy. Acta Neuropathologica Communications. 8: 137. PMID 32811565 DOI: 10.1186/S40478-020-01014-4 |
0.837 |
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| 2020 |
Busche MA, Hyman BT. Synergy between amyloid-β and tau in Alzheimer's disease. Nature Neuroscience. PMID 32778792 DOI: 10.1038/S41593-020-0687-6 |
0.529 |
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| 2020 |
Das S, Li Z, Noori A, Hyman BT, Serrano-Pozo A. Meta-analysis of mouse transcriptomic studies supports a context-dependent astrocyte reaction in acute CNS injury versus neurodegeneration. Journal of Neuroinflammation. 17: 227. PMID 32736565 DOI: 10.1186/S12974-020-01898-Y |
0.692 |
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| 2020 |
Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, ... ... Hyman BT, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 32572268 DOI: 10.1038/S41591-020-0938-9 |
0.846 |
|
| 2020 |
Huh YE, Ruby Chiang MS, Locascio JJ, Liao Z, Liu G, Choudhury K, Kuras YI, Tuncali I, Videnovic A, Hunt AL, Schwarzschild MA, Hung AY, Herrington TM, Hayes MT, Hyman BT, et al. β-Glucocerebrosidase Activity in -linked Parkinson's Disease: The Type of Mutation Matters. Neurology. PMID 32540937 DOI: 10.1212/Wnl.0000000000009989 |
0.628 |
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| 2020 |
Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/Nyas.14371 |
0.445 |
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| 2020 |
Oakley DH, Chung M, Klickstein N, Commins C, Hyman BT, Frosch MP. The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aβ43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue. Journal of Neuropathology and Experimental Neurology. PMID 32388561 DOI: 10.1093/Jnen/Nlaa025 |
0.792 |
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| 2020 |
Rauch JN, Luna G, Guzman E, Audouard M, Challis C, Sibih YE, Leshuk C, Hernandez I, Wegmann S, Hyman BT, Gradinaru V, Kampmann M, Kosik KS. LRP1 is a master regulator of tau uptake and spread. Nature. 580: 381-385. PMID 32296178 DOI: 10.1038/S41586-020-2156-5 |
0.762 |
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| 2020 |
Bakshi R, Macklin EA, Hung AY, Hayes MT, Hyman BT, Wills AM, Gomperts SN, Growdon JH, Ascherio A, Scherzer CR, Schwarzschild MA. Associations of Lower Caffeine Intake and Plasma Urate Levels with Idiopathic Parkinson's Disease in the Harvard Biomarkers Study. Journal of Parkinson's Disease. 10: 505-510. PMID 32250320 DOI: 10.3233/Jpd-191882 |
0.612 |
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| 2020 |
Benetatos J, Bennett RE, Evans HT, Ellis SA, Hyman BT, Bodea LG, Götz J. PTEN activation contributes to neuronal and synaptic engulfment by microglia in tauopathy. Acta Neuropathologica. PMID 32236736 DOI: 10.1007/S00401-020-02151-9 |
0.704 |
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| 2020 |
Reiman EM, Arboleda-Velasquez JF, Quiroz YT, Huentelman MJ, Beach TG, Caselli RJ, Chen Y, Su Y, Myers AJ, Hardy J, Paul Vonsattel J, Younkin SG, Bennett DA, De Jager PL, Larson EB, ... ... Hyman BT, et al. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nature Communications. 11: 667. PMID 32015339 DOI: 10.1038/S41467-019-14279-8 |
0.602 |
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| 2019 |
Dujardin S, Hyman BT. Tau Prion-Like Propagation: State of the Art and Current Challenges. Advances in Experimental Medicine and Biology. 1184: 305-325. PMID 32096046 DOI: 10.1007/978-981-32-9358-8_23 |
0.755 |
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| 2019 |
Lau A, So RWL, Lau HHC, Sang JC, Ruiz-Riquelme A, Fleck SC, Stuart E, Menon S, Visanji NP, Meisl G, Faidi R, Marano MM, Schmitt-Ulms C, Wang Z, Fraser PE, ... ... Hyman BT, et al. α-Synuclein strains target distinct brain regions and cell types. Nature Neuroscience. PMID 31792467 DOI: 10.1038/S41593-019-0541-X |
0.339 |
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| 2019 |
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Hyman BT, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7 |
0.645 |
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| 2019 |
Gui Y, Marks JD, Das S, Hyman BT, Serrano-Pozo A. Characterization of the 18 kda translocator protein (tspo) expression in post-mortem normal and alzheimer's disease brains. Brain Pathology (Zurich, Switzerland). PMID 31276244 DOI: 10.1111/Bpa.12763 |
0.757 |
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| 2019 |
Wegmann S, Bennett RE, Delorme L, Robbins AB, Hu M, McKenzie D, Kirk MJ, Schiantarelli J, Tunio N, Amaral AC, Fan Z, Nicholls S, Hudry E, Hyman BT. Experimental evidence for the age dependence of tau protein spread in the brain. Science Advances. 5: eaaw6404. PMID 31249873 DOI: 10.1126/Sciadv.Aaw6404 |
0.844 |
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| 2019 |
Sala Frigerio C, Wolfs L, Fattorelli N, Thrupp N, Voytyuk I, Schmidt I, Mancuso R, Chen WT, Woodbury ME, Srivastava G, Möller T, Hudry E, Das S, Saido T, Karran E, ... Hyman B, et al. The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques. Cell Reports. 27: 1293-1306.e6. PMID 31018141 DOI: 10.1016/J.Celrep.2019.03.099 |
0.428 |
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| 2019 |
Bihlmeyer NA, Merrill E, Lambert Y, Srivastava GP, Clark TW, Hyman BT, Das S. Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30935898 DOI: 10.1016/J.Jalz.2019.01.011 |
0.407 |
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| 2019 |
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Hyman BT, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2 |
0.634 |
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| 2019 |
Hudry E, Klickstein J, Cannavo C, Jackson R, Muzikansky A, Gandhi S, Urick D, Sargent T, Wrobleski L, Roe AD, Hou SS, Kuchibhotla KV, Betensky RA, Spires-Jones T, Hyman BT. Opposing Roles of apolipoprotein E in aging and neurodegeneration. Life Science Alliance. 2. PMID 30760557 DOI: 10.26508/lsa.201900325 |
0.738 |
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| 2019 |
Hyman B, Tanzi RE. Effects of Species-Specific Genetics on Alzheimer's Mouse Models. Neuron. 101: 351-352. PMID 30731053 DOI: 10.1016/J.Neuron.2019.01.021 |
0.422 |
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| 2019 |
Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, ... ... Hyman BT, et al. Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain : a Journal of Neurology. PMID 30689776 DOI: 10.1093/Brain/Awy327 |
0.459 |
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| 2019 |
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Hyman BT, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031 |
0.83 |
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| 2019 |
Henstridge CM, Hyman BT, Spires-Jones TL. Beyond the neuron-cellular interactions early in Alzheimer disease pathogenesis. Nature Reviews. Neuroscience. 20: 94-108. PMID 30643230 DOI: 10.1038/S41583-018-0113-1 |
0.825 |
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| 2019 |
Busche MA, Wegmann S, Dujardin S, Commins C, Schiantarelli J, Klickstein N, Kamath TV, Carlson GA, Nelken I, Hyman BT. Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo. Nature Neuroscience. 22: 57-64. PMID 30559471 DOI: 10.1038/S41593-018-0289-8 |
0.849 |
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| 2019 |
Dujardin S, Commins C, Kamath TV, De Los Santos M, Dooley PM, Moore BD, Jean-Gilles D, Clark R, Kennedy M, Hyman BT. RELEVANCE OF TAU SEEDING FOR THE CLINICAL HETEROGENEITY OF ALZHEIMER’S DISEASE: IMPLICATION FOR THERAPEUTIC PERSPECTIVES Alzheimer's & Dementia. 15: P1623. DOI: 10.1016/J.Jalz.2019.06.4854 |
0.729 |
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| 2018 |
Dujardin S, Bégard S, Caillierez R, Lachaud C, Carrier S, Lieger S, Gonzalez JA, Deramecourt V, Déglon N, Maurage CA, Frosch MP, Hyman BT, Colin M, Buée L. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathologica Communications. 6: 132. PMID 30497516 DOI: 10.1186/S40478-018-0637-7 |
0.845 |
|
| 2018 |
Broce IJ, Tan CH, Fan CC, Jansen I, Savage JE, Witoelar A, Wen N, Hess CP, Dillon WP, Glastonbury CM, Glymour M, Yokoyama JS, Elahi FM, Rabinovici GD, Miller BL, ... ... Hyman BT, et al. Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathologica. PMID 30413934 DOI: 10.1007/S00401-018-1928-6 |
0.402 |
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| 2018 |
Bennett RE, Bryant A, Hu M, Robbins AB, Hopp SC, Hyman BT. Partial reduction of microglia does not affect tau pathology in aged mice. Journal of Neuroinflammation. 15: 311. PMID 30413160 DOI: 10.1186/S12974-018-1348-5 |
0.833 |
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| 2018 |
Hopp SC, Lin Y, Oakley D, Roe AD, DeVos SL, Hanlon D, Hyman BT. The role of microglia in processing and spreading of bioactive tau seeds in Alzheimer's disease. Journal of Neuroinflammation. 15: 269. PMID 30227881 DOI: 10.1186/S12974-018-1309-Z |
0.855 |
|
| 2018 |
Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Hyman BT, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039 |
0.859 |
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| 2018 |
Wu HY, Kuo PC, Wang YT, Lin HT, Roe AD, Wang BY, Han CL, Hyman BT, Chen YJ, Tai HC. β-Amyloid Induces Pathology-Related Patterns of Tau Hyperphosphorylation at Synaptic Terminals. Journal of Neuropathology and Experimental Neurology. PMID 30016458 DOI: 10.1093/Jnen/Nly059 |
0.493 |
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| 2018 |
Kara E, Marks JD, Roe AD, Commins C, Fan Z, Calvo-Rodriguez M, Wegmann S, Hudry E, Hyman BT. A flow cytometry-based in vitro assay reveals that formation of apolipoprotein E (ApoE)-amyloid beta complexes depends on ApoE isoform- and cell type. The Journal of Biological Chemistry. PMID 29950521 DOI: 10.1074/Jbc.Ra117.001388 |
0.723 |
|
| 2018 |
Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Hyman BT, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757 |
0.432 |
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| 2018 |
György B, Lööv C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, et al. CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Molecular Therapy. Nucleic Acids. 11: 429-440. PMID 29858078 DOI: 10.1016/J.Omtn.2018.03.007 |
0.484 |
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| 2018 |
Hopp SC, Bihlmeyer NA, Corradi JP, Vanderburg C, Cacace AM, Das S, Clark TW, Betensky RA, Hyman BT, Hudry E. Neuronal calcineurin transcriptional targets parallel changes observed in Alzheimer disease brain. Journal of Neurochemistry. PMID 29806693 DOI: 10.1111/Jnc.14469 |
0.769 |
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| 2018 |
Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of apolipoprotein E in β-amyloidogenesis: Isoform-specific effects on protofibril to fibril conversion of Aβ and brain Aβ deposition . The Journal of Biological Chemistry. 293: 7267. PMID 29752420 DOI: 10.1074/jbc.AAC118.003576 |
0.688 |
|
| 2018 |
DeVos SL, Corjuc BT, Oakley DH, Nobuhara CK, Bannon RN, Chase A, Commins C, Gonzalez JA, Dooley PM, Frosch MP, Hyman BT. Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. Frontiers in Neuroscience. 12: 267. PMID 29740275 DOI: 10.3389/Fnins.2018.00267 |
0.816 |
|
| 2018 |
DeVos SL, Corjuc BT, Commins C, Dujardin S, Bannon RN, Corjuc D, Moore BD, Bennett RE, Jorfi M, Gonzales JA, Dooley PM, Roe AD, Pitstick R, Irimia D, Frosch MP, ... ... Hyman BT, et al. Tau reduction in the presence of amyloid-β prevents tau pathology and neuronal death in vivo. Brain : a Journal of Neurology. PMID 29733334 DOI: 10.1093/Brain/Awy117 |
0.848 |
|
| 2018 |
Mari SA, Wegmann S, Tepper K, Hyman BT, Mandelkow EM, Mandelkow E, Müller DJ. Reversible Cation-Selective Attachment and Self-Assembly of Human Tau on Supported Brain Lipid Membranes. Nano Letters. PMID 29644863 DOI: 10.1021/Acs.Nanolett.8B01085 |
0.743 |
|
| 2018 |
Liao F, Li A, Xiong M, Bien-Ly N, Jiang H, Zhang Y, Finn MB, Hoyle R, Keyser J, Lefton KB, Robinson GO, Serrano JR, Silverman AP, Guo JL, Getz J, ... ... Hyman BT, et al. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation. The Journal of Clinical Investigation. PMID 29600961 DOI: 10.1172/Jci96429 |
0.469 |
|
| 2018 |
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, ... ... Hyman BT, et al. Tau protein liquid-liquid phase separation can initiate tau aggregation. The Embo Journal. PMID 29472250 DOI: 10.15252/Embj.201798049 |
0.84 |
|
| 2018 |
György B, Cruz L, Yellen D, Aufiero M, Alland I, Zhang X, Ericsson M, Fraefel C, Li YC, Takeda S, Hyman BT, Breakefield XO. Mutant torsinA in the heterozygous DYT1 state compromises HSV propagation in infected neurons and fibroblasts. Scientific Reports. 8: 2324. PMID 29396398 DOI: 10.1038/S41598-018-19865-2 |
0.331 |
|
| 2018 |
Bennett RE, Robbins AB, Hu M, Cao X, Betensky RA, Clark T, Das S, Hyman BT. Tau induces blood vessel abnormalities and angiogenesis-related gene expression in P301L transgenic mice and human Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29358399 DOI: 10.1073/Pnas.1710329115 |
0.708 |
|
| 2017 |
Tan CH, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Dillon WP, Bonham LW, Yokoyama JS, Karch CM, Brewer JB, Rabinovici GD, Miller BL, Schellenberg GD, Kauppi K, ... ... Hyman BT, et al. Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition. Acta Neuropathologica. PMID 29177679 DOI: 10.1007/S00401-017-1789-4 |
0.422 |
|
| 2017 |
Colom-Cadena M, Pegueroles J, Herrmann AG, Henstridge CM, Muñoz L, Querol-Vilaseca M, Martín-Paniello CS, Luque-Cabecerans J, Clarimon J, Belbin O, Núñez-Llaves R, Blesa R, Smith C, McKenzie CA, Frosch MP, ... ... Hyman BT, et al. Synaptic phosphorylated α-synuclein in dementia with Lewy bodies. Brain : a Journal of Neurology. 140: 3204-3214. PMID 29177427 DOI: 10.1093/Brain/Awx275 |
0.81 |
|
| 2017 |
Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T. Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. Journal of Alzheimer's Disease : Jad. PMID 29036824 DOI: 10.3233/Jad-170511 |
0.357 |
|
| 2017 |
Tan CH, Hyman BT, Tan JJX, Hess CP, Dillon WP, Schellenberg GD, Besser LM, Kukull WA, Kauppi K, McEvoy LK, Andreassen OA, Dale AM, Fan CC, Desikan RS. Polygenic hazard scores in preclinical Alzheimer disease. Annals of Neurology. 82: 484-488. PMID 28940650 DOI: 10.1002/Ana.25029 |
0.41 |
|
| 2017 |
William CM, Saqran L, Stern MA, Chiang CL, Herrick S, Rangwala A, Albers MW, Frosch MP, Hyman BT. Activity-dependent dysfunction in visual and olfactory sensory systems in mouse models of Down syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28899917 DOI: 10.1523/Jneurosci.1045-17.2017 |
0.504 |
|
| 2017 |
Wegmann S, Bennett RE, Amaral AS, Hyman BT. Studying tau protein propagation and pathology in the mouse brain using adeno-associated viruses. Methods in Cell Biology. 141: 307-322. PMID 28882310 DOI: 10.1016/Bs.Mcb.2017.06.014 |
0.83 |
|
| 2017 |
Hernández-Vega A, Braun M, Scharrel L, Jahnel M, Wegmann S, Hyman BT, Alberti S, Diez S, Hyman AA. Local Nucleation of Microtubule Bundles through Tubulin Concentration into a Condensed Tau Phase. Cell Reports. 20: 2304-2312. PMID 28877466 DOI: 10.1016/j.celrep.2017.08.042 |
0.65 |
|
| 2017 |
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Hyman BT, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916 |
0.8 |
|
| 2017 |
Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT. Isoform and cell type-specific structure of Apolipoprotein E lipoparticles as revealed by a novel Forster Resonance Energy Transfer assay. The Journal of Biological Chemistry. PMID 28684412 DOI: 10.1074/Jbc.M117.784264 |
0.793 |
|
| 2017 |
Nicholls SB, DeVos SL, Commins C, Nobuhara C, Bennett RE, Corjuc DL, Maury E, Eftekharzadeh B, Akingbade O, Fan Z, Roe AD, Takeda S, Wegmann S, Hyman BT. Characterization of TauC3 antibody and demonstration of its potential to block tau propagation. Plos One. 12: e0177914. PMID 28531180 DOI: 10.1371/Journal.Pone.0177914 |
0.823 |
|
| 2017 |
DeVos SL, Hyman BT. Tau at the Crossroads between Neurotoxicity and Neuroprotection. Neuron. 94: 703-704. PMID 28521124 DOI: 10.1016/J.Neuron.2017.05.001 |
0.366 |
|
| 2017 |
Bennett RE, DeVos SL, Dujardin S, Corjuc B, Gor R, Gonzalez J, Roe AD, Frosch MP, Pitstick R, Carlson GA, Hyman BT. Enhanced Tau Aggregation in the Presence of Amyloid β. The American Journal of Pathology. PMID 28500862 DOI: 10.1016/J.Ajpath.2017.03.011 |
0.848 |
|
| 2017 |
Nobuhara CK, DeVos SL, Commins C, Wegmann S, Moore BD, Roe AD, Costantino I, Frosch MP, Pitstick R, Carlson GA, Hock C, Nitsch RM, Montrasio F, Grimm J, Cheung AE, ... ... Hyman BT, et al. Tau Antibody-Targeting Pathological Species Block Neuronal Uptake and Interneuron Propagation of Tau in Vitro. The American Journal of Pathology. PMID 28408124 DOI: 10.1016/J.Ajpath.2017.01.022 |
0.78 |
|
| 2017 |
Williams EA, McGuone D, Frosch MP, Hyman BT, Laver N, Stemmer-Rachamimov A. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. Journal of Neuropathology and Experimental Neurology. PMID 28379416 DOI: 10.1093/Jnen/Nlx020 |
0.641 |
|
| 2017 |
Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ. Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Molecular Neurodegeneration. 12: 27. PMID 28327181 DOI: 10.1186/S13024-017-0169-9 |
0.778 |
|
| 2017 |
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... ... Hyman BT, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/Journal.Pmed.1002258 |
0.372 |
|
| 2017 |
Qian J, Hyman BT, Betensky RA. Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms: Modeling Using an Autopsy Cohort and Application to Clinical Trial Design. Jama Neurology. PMID 28288263 DOI: 10.1001/Jamaneurol.2016.5953 |
0.325 |
|
| 2017 |
Thaker AA, Weinberg BD, Dillon WP, Hess CP, Cabral HJ, Fleischman DA, Leurgans SE, Bennett DA, Hyman BT, Albert MS, Killiany RJ, Fischl B, Dale AM, Desikan RS. Entorhinal Cortex: Antemortem Cortical Thickness and Postmortem Neurofibrillary Tangles and Amyloid Pathology. Ajnr. American Journal of Neuroradiology. PMID 28279988 DOI: 10.3174/Ajnr.A5133 |
0.33 |
|
| 2017 |
Yokoyama JS, Karch CM, Fan CC, Bonham LW, Kouri N, Ross OA, Rademakers R, Kim J, Wang Y, Höglinger GU, Müller U, Ferrari R, Hardy J, Momeni P, ... ... Hyman BT, et al. Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia. Acta Neuropathologica. PMID 28271184 DOI: 10.1007/S00401-017-1693-Y |
0.579 |
|
| 2017 |
Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. Jama Neurology. PMID 28241163 DOI: 10.1001/Jamaneurol.2016.5755 |
0.477 |
|
| 2017 |
Pickett EK, Henstridge CM, Allison E, Pitstick R, Pooler A, Wegmann S, Carlson G, Hyman BT, Spires-Jones TL. Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease. Synapse (New York, N.Y.). PMID 28196395 DOI: 10.1002/Syn.21965 |
0.835 |
|
| 2017 |
Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production. Molecular Neurodegeneration. 12: 15. PMID 28193235 DOI: 10.1186/S13024-017-0159-Y |
0.43 |
|
| 2017 |
Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 6. PMID 28132667 DOI: 10.7554/Elife.19720 |
0.6 |
|
| 2016 |
Marquié M, Normandin MD, Meltzer AC, Siao Tick Chong M, Andrea NV, Antón-Fernández A, Klunk WE, Mathis CA, Ikonomovic MD, Debnath M, Bien EA, Vanderburg CR, Costantino I, Makaretz S, DeVos SL, ... ... Hyman BT, et al. Pathologic correlations of [F-18]-AV-1451 imaging in non-Alzheimer tauopathies. Annals of Neurology. PMID 27997036 DOI: 10.1002/Ana.24844 |
0.808 |
|
| 2016 |
Dashkoff J, Lerner EP, Truong N, Klickstein JA, Fan Z, Mu D, Maguire CA, Hyman BT, Hudry E. Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9. Molecular Therapy. Methods & Clinical Development. 3: 16081. PMID 27933308 DOI: 10.1038/Mtm.2016.81 |
0.329 |
|
| 2016 |
Jackson RJ, Rudinskiy N, Herrmann AG, Croft S, Kim JM, Petrova V, Ramos-Rodriguez JJ, Pitstick R, Wegmann S, Garcia-Alloza M, Carlson GA, Hyman BT, Spires-Jones TL. Human tau increases amyloid β plaque size but not amyloid β-mediated synapse loss in a novel mouse model of Alzheimer's disease. The European Journal of Neuroscience. PMID 27748574 DOI: 10.1111/Ejn.13442 |
0.848 |
|
| 2016 |
Wegmann S, Nicholls S, Takeda S, Fan Z, Hyman BT. Formation, release, and internalization of stable tau oligomers in cells. Journal of Neurochemistry. PMID 27731899 DOI: 10.1111/Jnc.13866 |
0.745 |
|
| 2016 |
Merkel SF, Andrews AM, Lutton EM, Mu D, Hudry E, Hyman BT, Maguire CA, Ramirez SH. Trafficking of AAV vectors across a model of the blood-brain barrier; a comparative study of transcytosis and transduction using primary human brain endothelial cells. Journal of Neurochemistry. PMID 27718541 DOI: 10.1111/Jnc.13861 |
0.311 |
|
| 2016 |
Albers AD, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic Memory of Odors Stratifies Alzheimer Biomarkers in Normal Elderly. Annals of Neurology. PMID 27696605 DOI: 10.1002/Ana.24792 |
0.385 |
|
| 2016 |
Liu J, Costantino I, Venugopalan N, Fischetti RF, Hyman BT, Frosch MP, Gomez-Isla T, Makowski L. Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue. Scientific Reports. 6: 33079. PMID 27629394 DOI: 10.1038/Srep33079 |
0.603 |
|
| 2016 |
Chung WS, Verghese PB, Chakraborty C, Joung J, Hyman BT, Ulrich JD, Holtzman DM, Barres BA. Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27559087 DOI: 10.1073/Pnas.1609896113 |
0.402 |
|
| 2016 |
Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. PMID 27473132 DOI: 10.1212/Wnl.0000000000003050 |
0.414 |
|
| 2016 |
Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, Duff KE. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. Plos One. 11: e0159463. PMID 27466814 DOI: 10.1371/Journal.Pone.0159463 |
0.789 |
|
| 2016 |
Takeda S, Commins C, DeVos SL, Nobuhara CK, Wegmann S, Roe AD, Costantino I, Fan Z, Nicholls SB, Sherman AE, Trisini Lipsanopoulos AT, Scherzer CR, Carlson GA, Pitstick R, Peskind ER, ... ... Hyman BT, et al. Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Annals of Neurology. PMID 27351289 DOI: 10.1002/Ana.24716 |
0.795 |
|
| 2016 |
Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-β within Synapses. Journal of Alzheimer's Disease : Jad. PMID 27258414 DOI: 10.3233/Jad-160007 |
0.834 |
|
| 2016 |
Beglopoulos V, Tulloch J, Roe AD, Daumas S, Ferrington L, Watson R, Fan Z, Hyman BT, Kelly PA, Bard F, Morris RG. Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice. Nature Communications. 7: 11761. PMID 27249364 DOI: 10.1038/Ncomms11761 |
0.391 |
|
| 2016 |
Rudinskiy N, Fuerer C, Demurtas D, Zamorano S, De Piano C, Herrmann A, Spires-Jones TL, Oeckl P, Otto M, Frosch MP, Moniatte M, Hyman BT, Schmid AW. Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27130892 DOI: 10.1016/J.Jalz.2016.03.011 |
0.837 |
|
| 2016 |
Serrano-Pozo A, Qian J, Muzikansky A, Monsell SE, Montine TJ, Frosch MP, Betensky RA, Hyman BT. Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum. Journal of Neuropathology and Experimental Neurology. PMID 27105663 DOI: 10.1093/Jnen/Nlw026 |
0.77 |
|
| 2016 |
Yokoyama JS, Wang Y, Schork AJ, Thompson WK, Karch CM, Cruchaga C, McEvoy LK, Witoelar A, Chen CH, Holland D, Brewer JB, Franke A, Dillon WP, Wilson DM, Mukherjee P, ... ... Hyman BT, et al. Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease. Jama Neurology. PMID 27088644 DOI: 10.1001/Jamaneurol.2016.0150 |
0.449 |
|
| 2016 |
Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. Bmc Biology. 14: 25. PMID 27036734 DOI: 10.1186/S12915-016-0248-3 |
0.423 |
|
| 2016 |
Eftekharzadeh B, Hyman BT, Wegmann S. Structural studies on the mechanism of protein aggregation in age related neurodegenerative diseases. Mechanisms of Ageing and Development. 156: 1-13. PMID 27005270 DOI: 10.1016/J.Mad.2016.03.001 |
0.691 |
|
| 2016 |
Lööv C, Scherzer CR, Hyman BT, Breakefield XO, Ingelsson M. α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities. Cellular and Molecular Neurobiology. PMID 26993503 DOI: 10.1007/S10571-015-0317-0 |
0.326 |
|
| 2016 |
Hudry E, Martin C, Gandhi S, György B, Scheffer DI, Mu D, Merkel SF, Mingozzi F, Fitzpatrick Z, Dimant H, Masek M, Ragan T, Tan S, Brisson AR, Ramirez SH, ... Hyman BT, et al. Exosome-associated AAV vector as a robust and convenient neuroscience tool. Gene Therapy. PMID 26836117 DOI: 10.1038/Gt.2016.11 |
0.772 |
|
| 2016 |
Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Author response: Pathogenic PS1 phosphorylation at Ser367 Elife. DOI: 10.7554/Elife.19720.023 |
0.501 |
|
| 2016 |
Silvestri L, Rudinskiy N, Paciscopi M, Müllenbroich MC, Costantini I, Sacconi L, Frasconi P, Hyman BT, Pavone FS. Mapping whole-brain activity with cellular resolution by light-sheet microscopy and high-throughput image analysis (Conference Presentation) Proceedings of Spie. 9690: 969012. DOI: 10.1117/12.2208603 |
0.321 |
|
| 2016 |
Hudry E, Dashkoff J, Lerner P, Takeda S, Truong N, Maguire C, Hyman BT. 616. Tailored Expression of a Transgene to Specific Cell Types in the Central Nervous System After Peripheral Injection of AAV9 Molecular Therapy. 24: S244. DOI: 10.1016/S1525-0016(16)33424-4 |
0.346 |
|
| 2016 |
Gyorgy B, Ingelsson M, Loov C, Takeda S, Lannfelt L, Hyman BT, Breakefield XO. 567. CRISPR-Cas9 Mediated Gene Editing in a Monogenic Form of Alzheimer's Disease Molecular Therapy. 24: S226-S227. DOI: 10.1016/S1525-0016(16)33375-5 |
0.324 |
|
| 2016 |
Hyman B. Tau and Alzheimer pathobiology Neurobiology of Aging. 39: S16. DOI: 10.1016/J.Neurobiolaging.2016.01.076 |
0.502 |
|
| 2016 |
Pickett E, Henstridge C, Jackson RJ, Herrmann AG, Wegmann S, Hyman BT, Carlson GA, Spires-Jones TL. EC-03-03: Tau Spreading and Toxicity Alzheimer's & Dementia. 12: P269-P269. DOI: 10.1016/J.Jalz.2016.06.2381 |
0.814 |
|
| 2015 |
Feke GT, Hyman BT, Stern RA, Pasquale LR. Retinal blood flow in mild cognitive impairment and Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 144-51. PMID 27239502 DOI: 10.1016/J.Dadm.2015.01.004 |
0.346 |
|
| 2015 |
Serrano-Pozo A, Betensky RA, Frosch MP, Hyman BT. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. The American Journal of Pathology. PMID 26687817 DOI: 10.1016/J.Ajpath.2015.10.010 |
0.792 |
|
| 2015 |
Galea E, Morrison W, Hudry E, Arbel-Ornath M, Bacskai BJ, Gómez-Isla T, Stanley HE, Hyman BT. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644572 DOI: 10.1073/Pnas.1516779112 |
0.611 |
|
| 2015 |
Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Scientific Reports. 5: 16622. PMID 26564777 DOI: 10.1038/Srep16622 |
0.837 |
|
| 2015 |
Serrano-Pozo A, Hyman BT. Alzheimer Disease: Alzheimer dementia with sparse amyloid-AD mimic or variant? Nature Reviews. Neurology. PMID 26553593 DOI: 10.1038/Nrneurol.2015.221 |
0.776 |
|
| 2015 |
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe A, DeVos SL, Nicholls S, Fan Z, Takeda S, Cagsal-Getkin O, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler AM, ... Hyman BT, et al. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. The Embo Journal. PMID 26538322 DOI: 10.15252/Embj.201592748 |
0.849 |
|
| 2015 |
Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, ... ... Hyman B, et al. Tau PET imaging in aging and early Alzheimer's disease. Annals of Neurology. PMID 26505746 DOI: 10.1002/Ana.24546 |
0.477 |
|
| 2015 |
Takeda S, Wegmann S, Cho H, DeVos SL, Commins C, Roe AD, Nicholls SB, Carlson GA, Pitstick R, Nobuhara CK, Costantino I, Frosch MP, Müller DJ, Irimia D, Hyman BT. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nature Communications. 6: 8490. PMID 26458742 DOI: 10.1038/Ncomms9490 |
0.796 |
|
| 2015 |
Marquié M, Normandin MD, Vanderburg CR, Costantino IM, Bien EA, Rycyna LG, Klunk WE, Mathis CA, Ikonomovic MD, Debnath ML, Vasdev N, Dickerson BC, Gomperts SN, Growdon JH, Johnson KA, ... ... Hyman BT, et al. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Annals of Neurology. PMID 26344059 DOI: 10.1002/Ana.24517 |
0.643 |
|
| 2015 |
Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, ... ... Hyman BT, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/J.Jalz.2015.07.492 |
0.599 |
|
| 2015 |
Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887 |
0.581 |
|
| 2015 |
Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Hyman BT, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a Journal of Neurology. 138: 2701-15. PMID 26220940 DOI: 10.1093/Brain/Awv199 |
0.439 |
|
| 2015 |
Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... ... Hyman BT, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease. Brain : a Journal of Neurology. 138: 2659-71. PMID 26220939 DOI: 10.1093/Brain/Awv202 |
0.671 |
|
| 2015 |
Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiology of Disease. PMID 26102023 DOI: 10.1016/J.Nbd.2015.06.013 |
0.38 |
|
| 2015 |
Bachhuber T, Katzmarski N, McCarter JF, Loreth D, Tahirovic S, Kamp F, Abou-Ajram C, Nuscher B, Serrano-Pozo A, Müller A, Prinz M, Steiner H, Hyman BT, Haass C, Meyer-Luehmann M. Inhibition of amyloid-β plaque formation by α-synuclein. Nature Medicine. 21: 802-7. PMID 26099047 DOI: 10.1038/Nm.3885 |
0.762 |
|
| 2015 |
Yang Y, Keene CD, Peskind ER, Galasko DR, Hu SC, Cudaback E, Wilson AM, Li G, Yu CE, Montine KS, Zhang J, Baird GS, Hyman BT, Montine TJ. Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease. Journal of Neuropathology and Experimental Neurology. 74: 672-87. PMID 26083568 DOI: 10.1097/Nen.0000000000000207 |
0.392 |
|
| 2015 |
von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper C, Boeckers TM, Rueck A, Wirth T, Hyman BT, Danzer KM, Thal DR, von Arnim CA. The Golgi-Localized γ-Ear-Containing ARF-Binding (GGA) Proteins Alter Amyloid-β Precursor Protein (APP) Processing through Interaction of Their GAE Domain with the Beta-Site APP Cleaving Enzyme 1 (BACE1). Plos One. 10: e0129047. PMID 26053850 DOI: 10.1371/Journal.Pone.0129047 |
0.817 |
|
| 2015 |
Hori Y, Hashimoto T, Nomoto H, Hyman BT, Iwatsubo T. Role of Apolipoprotein E in β-Amyloidogenesis: ISOFORM-SPECIFIC EFFECTS ON PROTOFIBRIL TO FIBRIL CONVERSION OF Aβ IN VITRO AND BRAIN Aβ DEPOSITION IN VIVO. The Journal of Biological Chemistry. 290: 15163-74. PMID 25918154 DOI: 10.1074/Jbc.M114.622209 |
0.748 |
|
| 2015 |
Desikan RS, Schork AJ, Wang Y, Thompson WK, Dehghan A, Ridker PM, Chasman DI, McEvoy LK, Holland D, Chen CH, Karow DS, Brewer JB, Hess CP, Williams J, Sims R, ... ... Hyman BT, et al. Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease. Circulation. 131: 2061-9. PMID 25862742 DOI: 10.1161/Circulationaha.115.015489 |
0.438 |
|
| 2015 |
Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, William C, Saqran L, Cagsal-Getkin O, Pitstick R, Beier DR, Carlson GA, Spires-Jones TL, Hyman BT. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer's disease. Acta Neuropathologica Communications. 3: 14. PMID 25853174 DOI: 10.1186/S40478-015-0199-X |
0.847 |
|
| 2015 |
Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid. Alzheimer's Research & Therapy. 7: 14. PMID 25802556 DOI: 10.1186/S13195-015-0100-Y |
0.401 |
|
| 2015 |
Jellinger KA, Alafuzoff I, Attems J, Beach TG, Cairns NJ, Crary JF, Dickson DW, Hof PR, Hyman BT, Jack CR, Jicha GA, Knopman DS, Kovacs GG, Mackenzie IR, Masliah E, et al. PART, a distinct tauopathy, different from classical sporadic Alzheimer disease. Acta Neuropathologica. 129: 757-62. PMID 25778618 DOI: 10.1007/S00401-015-1407-2 |
0.492 |
|
| 2015 |
Kaushal V, Dye R, Pakavathkumar P, Foveau B, Flores J, Hyman B, Ghetti B, Koller BH, LeBlanc AC. Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation. Cell Death and Differentiation. PMID 25744023 DOI: 10.1038/Cdd.2015.16 |
0.395 |
|
| 2015 |
Desikan RS, Schork AJ, Wang Y, Witoelar A, Sharma M, McEvoy LK, Holland D, Brewer JB, Chen CH, Thompson WK, Harold D, Williams J, Owen MJ, O'Donovan MC, Pericak-Vance MA, ... ... Hyman BT, et al. Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus. Molecular Psychiatry. PMID 25687773 DOI: 10.1038/Mp.2015.6 |
0.408 |
|
| 2015 |
Serrano-Pozo A, Qian J, Monsell SE, Betensky RA, Hyman BT. APOEε2 is associated with milder clinical and pathological Alzheimer disease. Annals of Neurology. 77: 917-29. PMID 25623662 DOI: 10.1002/Ana.24369 |
0.764 |
|
| 2015 |
Hyman BT, Holtzman DM. Apolipoprotein E levels and Alzheimer risk. Annals of Neurology. 77: 204-5. PMID 25583643 DOI: 10.1002/Ana.24355 |
0.322 |
|
| 2015 |
Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Hyman BT, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157 |
0.693 |
|
| 2015 |
Hori Y, Takeda S, Cho H, Wegmann S, Shoup TM, Takahashi K, Irimia D, Elmaleh DR, Hyman BT, Hudry E. A Food and Drug Administration-approved asthma therapeutic agent impacts amyloid β in the brain in a transgenic model of Alzheimer disease. The Journal of Biological Chemistry. 290: 1966-78. PMID 25468905 DOI: 10.1074/Jbc.M114.586602 |
0.717 |
|
| 2015 |
Saidi LJ, Polydoro M, Kay KR, Sanchez L, Mandelkow EM, Hyman BT, Spires-Jones TL. Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes. Journal of Alzheimer's Disease : Jad. 44: 937-47. PMID 25374103 DOI: 10.3233/Jad-142094 |
0.841 |
|
| 2015 |
Albers MW, Gilmore GC, Kaye J, Murphy C, Wingfield A, Bennett DA, Boxer AL, Buchman AS, Cruickshanks KJ, Devanand DP, Duffy CJ, Gall CM, Gates GA, Granholm AC, Hensch T, ... ... Hyman BT, et al. At the interface of sensory and motor dysfunctions and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 70-98. PMID 25022540 DOI: 10.1016/J.Jalz.2014.04.514 |
0.358 |
|
| 2015 |
Silvestri L, Rudinskiy N, Paciscopi M, Müllenbroich MC, Costantini I, Sacconi L, Frasconi P, Hyman BT, Pavone FS. Brain-wide charting of neuronal activation maps with cellular resolution Optics and the Brain, Brain 2015. DOI: 10.1364/Brain.2015.Brm3B.6 |
0.32 |
|
| 2015 |
Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, ... ... Hyman BT, et al. Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease Brain. 138: 2659-2671. DOI: 10.1093/brain/awv202 |
0.616 |
|
| 2015 |
Toledo JB, Zetterberg H, Van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, ... ... Hyman BT, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects Brain. 138: 2701-2715. DOI: 10.1093/brain/awv199 |
0.327 |
|
| 2015 |
Hudry EM, Martin C, Mu D, Mingozzi F, Hyman BT, Maguire CA. 312. Highly-Efficient CNS Transduction With Vesicle-Associated AAV Vector Molecular Therapy. 23: S126. DOI: 10.1016/S1525-0016(16)33921-1 |
0.311 |
|
| 2015 |
Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. O4-01-04: Entorhinal, parahippocampal, and inferior temporal F18-T807 SUVR correlates with CSF total tau and tau T181P in cognitively normal elderly Alzheimer's & Dementia. 11: P267-P267. DOI: 10.1016/J.Jalz.2015.07.348 |
0.33 |
|
| 2015 |
Hyman BT. S4-02-02: Modeling braak-like progression of tangles in the medial temporal lobe Alzheimer's & Dementia. 11: P258-P258. DOI: 10.1016/J.Jalz.2015.07.326 |
0.306 |
|
| 2015 |
Wegmann S, Maury EA, Kirk MJ, Saqran L, Roe AD, Fan Z, Nicholls SB, DeVos SL, Takeda S, William CM, Spires-Jones TL, Pitstick R, Carlson GA, Pooler A, Hyman BT. O2-06-01: Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice Alzheimer's & Dementia. 11: P186-P186. DOI: 10.1016/J.Jalz.2015.07.159 |
0.816 |
|
| 2015 |
Takeda S, Commins C, Wegmann S, Roe AD, Fan Z, DeVos SL, Costantino I, Trisini Lipsanopoulos A, Frosch MP, Hyman BT. P3-071: A unique high-molecular-weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer's disease patients Alzheimer's & Dementia. 11: P644-P644. DOI: 10.1016/J.Jalz.2015.06.938 |
0.751 |
|
| 2015 |
Fol R, Hudry E, Audrain M, Burlot M, Dufayet-Chaffaud G, Bemelmans A, Hyman BT, Cartier N, Braudeau J. Improved amyloid pathology contrasting with unexpected memory defects following astrocytic ApoE-e2 overexpression in hippocampus of Alzheimer’s mice Alzheimers & Dementia. 11: 347. DOI: 10.1016/J.Jalz.2015.06.223 |
0.357 |
|
| 2015 |
Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NHH, Hsiung GYR, Hyman B, Iqbal K, Kaeser SA, Lachno DR, et al. Erratum: CSF biomarker variability in the Alzheimer's Association quality control program (Alzheimer's and Dementia (2013) 9 (251-261)) Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2014.12.004 |
0.391 |
|
| 2014 |
Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, ... Hyman BT, et al. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathologica. 128: 755-66. PMID 25348064 DOI: 10.1007/S00401-014-1349-0 |
0.769 |
|
| 2014 |
Tai HC, Wang BY, Serrano-Pozo A, Frosch MP, Spires-Jones TL, Hyman BT. Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease. Acta Neuropathologica Communications. 2: 146. PMID 25330988 DOI: 10.1186/S40478-014-0146-2 |
0.807 |
|
| 2014 |
Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, et al. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathologica Communications. 2: 133. PMID 25200117 DOI: 10.1186/S40478-014-0133-7 |
0.588 |
|
| 2014 |
Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Hyman BT, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491 |
0.643 |
|
| 2014 |
Beecham GW, Hamilton K, Naj AC, Martin ER, Huentelman M, Myers AJ, Corneveaux JJ, Hardy J, Vonsattel JP, Younkin SG, Bennett DA, De Jager PL, Larson EB, Crane PK, Kamboh MI, ... ... Hyman BT, et al. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. Plos Genetics. 10: e1004606. PMID 25188341 DOI: 10.1371/Journal.Pgen.1004606 |
0.615 |
|
| 2014 |
Hyman BT. Tau propagation, different tau phenotypes, and prion-like properties of tau. Neuron. 82: 1189-90. PMID 24945760 DOI: 10.1016/J.Neuron.2014.06.004 |
0.469 |
|
| 2014 |
Rudinskiy N, Hawkes JM, Wegmann S, Kuchibhotla KV, Muzikansky A, Betensky RA, Spires-Jones TL, Hyman BT. Tau pathology does not affect experience-driven single-neuron and network-wide Arc/Arg3.1 responses. Acta Neuropathologica Communications. 2: 63. PMID 24915991 DOI: 10.1186/2051-5960-2-63 |
0.828 |
|
| 2014 |
Gu C, Chang J, Shchedrina VA, Pham VA, Hartwig JH, Suphamungmee W, Lehman W, Hyman BT, Bacskai BJ, Sever S. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic (Copenhagen, Denmark). 15: 819-38. PMID 24891099 DOI: 10.1111/Tra.12178 |
0.536 |
|
| 2014 |
Spires-Jones TL, Hyman BT. The intersection of amyloid beta and tau at synapses in Alzheimer's disease. Neuron. 82: 756-71. PMID 24853936 DOI: 10.1016/J.Neuron.2014.05.004 |
0.776 |
|
| 2014 |
Liao F, Hori Y, Hudry E, Bauer AQ, Jiang H, Mahan TE, Lefton KB, Zhang TJ, Dearborn JT, Kim J, Culver JP, Betensky R, Wozniak DF, Hyman BT, Holtzman DM. Anti-ApoE antibody given after plaque onset decreases Aβ accumulation and improves brain function in a mouse model of Aβ amyloidosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7281-92. PMID 24849360 DOI: 10.1523/Jneurosci.0646-14.2014 |
0.672 |
|
| 2014 |
Bit-Ivan EN, Suh E, Shim HS, Weintraub S, Hyman BT, Arnold SE, McCarty-Wood E, Van Deerlin VM, Schneider JA, Trojanowski JQ, Frosch MP, Baker MC, Rademakers R, Mesulam M, Bigio EH. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. Journal of Neuropathology and Experimental Neurology. 73: 467-73. PMID 24709683 DOI: 10.1097/Nen.0000000000000070 |
0.506 |
|
| 2014 |
Donovan NJ, Amariglio RE, Zoller AS, Rudel RK, Gomez-Isla T, Blacker D, Hyman BT, Locascio JJ, Johnson KA, Sperling RA, Marshall GA, Rentz DM. Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 22: 1642-51. PMID 24698445 DOI: 10.1016/J.Jagp.2014.02.007 |
0.387 |
|
| 2014 |
Marshall GA, Lorius N, Locascio JJ, Hyman BT, Rentz DM, Johnson KA, Sperling RA. Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum. Journal of Alzheimer's Disease : Jad. 41: 719-28. PMID 24685624 DOI: 10.3233/Jad-132768 |
0.356 |
|
| 2014 |
Dimant H, Zhu L, Kibuuka LN, Fan Z, Hyman BT, McLean PJ. Direct visualization of CHIP-mediated degradation of alpha-synuclein in vivo: implications for PD therapeutics. Plos One. 9: e92098. PMID 24664141 DOI: 10.1371/Journal.Pone.0092098 |
0.81 |
|
| 2014 |
Farrar CT, William CM, Hudry E, Hashimoto T, Hyman BT. RNA aptamer probes as optical imaging agents for the detection of amyloid plaques. Plos One. 9: e89901. PMID 24587111 DOI: 10.1371/Journal.Pone.0089901 |
0.616 |
|
| 2014 |
Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson KA, Frosch MP, Sperling RA, Hyman BT. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Annals of Neurology. 75: 597-601. PMID 24585367 DOI: 10.1002/Ana.24125 |
0.819 |
|
| 2014 |
Spires-Jones TL, Friedman T, Pitstick R, Polydoro M, Roe A, Carlson GA, Hyman BT. Methylene blue does not reverse existing neurofibrillary tangle pathology in the rTg4510 mouse model of tauopathy. Neuroscience Letters. 562: 63-8. PMID 24462887 DOI: 10.1016/J.Neulet.2014.01.013 |
0.854 |
|
| 2014 |
Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. The role of clusterin in amyloid-β-associated neurodegeneration. Jama Neurology. 71: 180-7. PMID 24378367 DOI: 10.1001/Jamaneurol.2013.4560 |
0.414 |
|
| 2014 |
Kuchibhotla KV, Wegmann S, Kopeikina KJ, Hawkes J, Rudinskiy N, Andermann ML, Spires-Jones TL, Bacskai BJ, Hyman BT. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proceedings of the National Academy of Sciences of the United States of America. 111: 510-4. PMID 24368848 DOI: 10.1073/Pnas.1318807111 |
0.851 |
|
| 2014 |
Growdon JH, Hyman BT. APOE genotype and brain development. Jama Neurology. 71: 7-8. PMID 24276019 DOI: 10.1001/Jamaneurol.2013.5200 |
0.617 |
|
| 2014 |
Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathologica. 127: 257-70. PMID 24271788 DOI: 10.1007/S00401-013-1215-5 |
0.852 |
|
| 2014 |
Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, et al. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure (London, England : 1993). 22: 125-35. PMID 24210759 DOI: 10.1016/J.Str.2013.09.018 |
0.442 |
|
| 2014 |
Ren Y, Lin WL, Sanchez L, Ceballos C, Polydoro M, Spires-Jones TL, Hyman BT, Dickson DW, Sahara N. Endogenous tau aggregates in oligodendrocytes of rTg4510 mice induced by human P301L tau. Journal of Alzheimer's Disease : Jad. 38: 589-600. PMID 24028867 DOI: 10.3233/Jad-130986 |
0.838 |
|
| 2014 |
Johnson KA, Mormino E, Rentz DM, Schultz A, Becker JA, Sepulcre J, Chhatwal J, Amariglio R, Papp K, Marshall G, Shoup T, Yokell D, Brady T, Hyman B, Vasdev N, et al. DT-01-02: TEMPORAL NEOCORTICAL TAU DEPOSITION MEASURED WITH PET IS ASSOCIATED WITH LONGITUDINAL DECLINE IN MEMORY PERFORMANCE AMONG CLINICALLY NORMAL ELDERLY Alzheimer's & Dementia. 10: P280-P280. DOI: 10.1016/J.Jalz.2014.07.150 |
0.429 |
|
| 2014 |
Fol RR, Hudry E, Audrain M, Burlot M, Dufayet-Chaffaud G, Bemelmans AP, Hyman BT, Cartier N, Braudeau J. Consequences Of Apoe2 Overexpression In Astrocytes In An Alzheimer'S Disease Mouse Model Alzheimers & Dementia. 10: 313. DOI: 10.1016/J.Jalz.2014.05.260 |
0.45 |
|
| 2014 |
Hudry E, Kuchibhotla K, Wrobleski L, Wegmann S, Arbel-Ornath M, Hyman B. O4-09-04: UNRAVELING THE ROLE OF APOLIPOPROTEIN E IN AGE- AND ABETA-RELATED NEURONAL DYSFUNCTION Alzheimer's & Dementia. 10: P269-P269. DOI: 10.1016/J.Jalz.2014.04.436 |
0.661 |
|
| 2013 |
Kopeikina KJ, Wegmann S, Pitstick R, Carlson GA, Bacskai BJ, Betensky RA, Hyman BT, Spires-Jones TL. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. Plos One. 8: e80834. PMID 24278327 DOI: 10.1371/Journal.Pone.0080834 |
0.824 |
|
| 2013 |
Hudry E, Dashkoff J, Roe AD, Takeda S, Koffie RM, Hashimoto T, Scheel M, Spires-Jones T, Arbel-Ornath M, Betensky R, Davidson BL, Hyman BT. Gene transfer of human Apoe isoforms results in differential modulation of amyloid deposition and neurotoxicity in mouse brain. Science Translational Medicine. 5: 212ra161. PMID 24259049 DOI: 10.1126/Scitranslmed.3007000 |
0.838 |
|
| 2013 |
Dimant H, Kalia SK, Kalia LV, Zhu LN, Kibuuka L, Ebrahimi-Fakhari D, McFarland NR, Fan Z, Hyman BT, McLean PJ. Direct detection of alpha synuclein oligomers in vivo. Acta Neuropathologica Communications. 1: 6. PMID 24252244 DOI: 10.1186/2051-5960-1-6 |
0.799 |
|
| 2013 |
Serrano-Pozo A, Qian J, Monsell SE, Frosch MP, Betensky RA, Hyman BT. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. Journal of Neuropathology and Experimental Neurology. 72: 1182-92. PMID 24226270 DOI: 10.1097/Nen.0000000000000016 |
0.789 |
|
| 2013 |
Pooler AM, Polydoro M, Wegmann S, Nicholls SB, Spires-Jones TL, Hyman BT. Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets. Alzheimer's Research & Therapy. 5: 49. PMID 24152385 DOI: 10.1186/Alzrt214 |
0.863 |
|
| 2013 |
Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635 |
0.71 |
|
| 2013 |
Desikan RS, Thompson WK, Holland D, Hess CP, Brewer JB, Zetterberg H, Blennow K, Andreassen OA, McEvoy LK, Hyman BT, Dale AM. Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration. Molecular Neurodegeneration. 8: 39. PMID 24088526 DOI: 10.1186/1750-1326-8-39 |
0.449 |
|
| 2013 |
Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, ... ... Hyman BT, et al. Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study. Neurology. 81: 1531-7. PMID 24068787 DOI: 10.1212/Wnl.0B013E3182A95818 |
0.603 |
|
| 2013 |
Kim T, Vidal GS, Djurisic M, William CM, Birnbaum ME, Garcia KC, Hyman BT, Shatz CJ. Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model. Science (New York, N.Y.). 341: 1399-404. PMID 24052308 DOI: 10.1126/Science.1242077 |
0.457 |
|
| 2013 |
Polydoro M, de Calignon A, Suárez-Calvet M, Sanchez L, Kay KR, Nicholls SB, Roe AD, Pitstick R, Carlson GA, Gómez-Isla T, Spires-Jones TL, Hyman BT. Reversal of neurofibrillary tangles and tau-associated phenotype in the rTgTauEC model of early Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13300-11. PMID 23946388 DOI: 10.1523/Jneurosci.0881-13.2013 |
0.847 |
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| 2013 |
Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, Tannous BA. Mouse gender influences brain transduction by intravascularly administered AAV9. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1470-1. PMID 23903572 DOI: 10.1038/Mt.2013.95 |
0.692 |
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| 2013 |
Herskovits AZ, Locascio JJ, Peskind ER, Li G, Hyman BT. A Luminex assay detects amyloid β oligomers in Alzheimer's disease cerebrospinal fluid. Plos One. 8: e67898. PMID 23844122 DOI: 10.1371/Journal.Pone.0067898 |
0.471 |
|
| 2013 |
Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. The Journal of Comparative Neurology. 521: 4236-48. PMID 23839581 DOI: 10.1002/Cne.23411 |
0.84 |
|
| 2013 |
Perez-Nievas BG, Stein TD, Tai HC, Dols-Icardo O, Scotton TC, Barroeta-Espar I, Fernandez-Carballo L, de Munain EL, Perez J, Marquie M, Serrano-Pozo A, Frosch MP, Lowe V, Parisi JE, Petersen RC, ... ... Hyman BT, et al. Dissecting phenotypic traits linked to human resilience to Alzheimer's pathology. Brain : a Journal of Neurology. 136: 2510-26. PMID 23824488 DOI: 10.1093/Brain/Awt171 |
0.826 |
|
| 2013 |
Kay KR, Smith C, Wright AK, Serrano-Pozo A, Pooler AM, Koffie R, Bastin ME, Bak TH, Abrahams S, Kopeikina KJ, McGuone D, Frosch MP, Gillingwater TH, Hyman BT, Spires-Jones TL. Studying synapses in human brain with array tomography and electron microscopy. Nature Protocols. 8: 1366-80. PMID 23787894 DOI: 10.1038/Nprot.2013.078 |
0.791 |
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| 2013 |
McCarter JF, Liebscher S, Bachhuber T, Abou-Ajram C, Hübener M, Hyman BT, Haass C, Meyer-Luehmann M. Clustering of plaques contributes to plaque growth in a mouse model of Alzheimer's disease. Acta Neuropathologica. 126: 179-88. PMID 23775142 DOI: 10.1007/S00401-013-1137-2 |
0.461 |
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| 2013 |
Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-β on microglial accumulation. Scientific Reports. 3: 1823. PMID 23665843 DOI: 10.1038/Srep01823 |
0.68 |
|
| 2013 |
Serrano-Pozo A, Muzikansky A, Gómez-Isla T, Growdon JH, Betensky RA, Frosch MP, Hyman BT. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 72: 462-71. PMID 23656989 DOI: 10.1097/Nen.0B013E3182933788 |
0.822 |
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| 2013 |
Takeda S, Hashimoto T, Roe AD, Hori Y, Spires-Jones TL, Hyman BT. Brain interstitial oligomeric amyloid β increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 3239-48. PMID 23640054 DOI: 10.1096/Fj.13-229666 |
0.82 |
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| 2013 |
Macklin EA, Blacker D, Hyman BT, Betensky RA. Improved design of prodromal Alzheimer's disease trials through cohort enrichment and surrogate endpoints. Journal of Alzheimer's Disease : Jad. 36: 475-86. PMID 23629586 DOI: 10.3233/Jad-122212 |
0.392 |
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| 2013 |
Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, Mullin K, Hooli B, Choi SH, Hyman BT, Tanzi RE. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 78: 631-43. PMID 23623698 DOI: 10.1016/J.Neuron.2013.04.014 |
0.724 |
|
| 2013 |
Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, et al. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 251-61. PMID 23622690 DOI: 10.1016/J.Jalz.2013.01.010 |
0.41 |
|
| 2013 |
Serrano-Pozo A, Gómez-Isla T, Growdon JH, Frosch MP, Hyman BT. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. The American Journal of Pathology. 182: 2332-44. PMID 23602650 DOI: 10.1016/J.Ajpath.2013.02.031 |
0.82 |
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| 2013 |
Walker LC, Diamond MI, Duff KE, Hyman BT. Mechanisms of protein seeding in neurodegenerative diseases. Jama Neurology. 70: 304-10. PMID 23599928 DOI: 10.1001/Jamaneurol.2013.1453 |
0.458 |
|
| 2013 |
Wahler A, Beyer AS, Keller IE, Schnack C, von Einem B, Pröpper C, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CA. Engulfment adaptor phosphotyrosine-binding-domain-containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and is transactivationally active together with low-density lipoprotein receptor-related protein 1 (LRP1). The Biochemical Journal. 450: 333-43. PMID 23167255 DOI: 10.1042/Bj20121100 |
0.343 |
|
| 2013 |
Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions. Neurobiology of Disease. 50: 127-34. PMID 23064434 DOI: 10.1016/J.Nbd.2012.10.002 |
0.682 |
|
| 2013 |
Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R, Hyman BT, Spires-Jones TL. Synaptic alterations in the rTg4510 mouse model of tauopathy. The Journal of Comparative Neurology. 521: 1334-53. PMID 23047530 DOI: 10.1002/Cne.23234 |
0.825 |
|
| 2013 |
Desikan RS, McEvoy LK, Holland D, Thompson WK, Brewer JB, Aisen PS, Andreassen OA, Hyman BT, Sperling RA, Dale AM. Apolipoprotein E epsilon4 does not modulate amyloid-β-associated neurodegeneration in preclinical Alzheimer disease. Ajnr. American Journal of Neuroradiology. 34: 505-10. PMID 22976236 DOI: 10.3174/Ajnr.A3267 |
0.415 |
|
| 2013 |
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Constructs used in this study and complementation results. Plos One. DOI: 10.1371/Journal.Pone.0001867.T001 |
0.673 |
|
| 2013 |
Okereke O, O'Brien J, Rentz D, Hyman B, Blacker D. P2-263: Planning large-scale Alzheimer's disease questionnaire-aided studies (PLAQUES): Concordance of remote assessment methods with in-person diagnosis Alzheimer's & Dementia. 9: P454-P454. DOI: 10.1016/J.Jalz.2013.05.910 |
0.338 |
|
| 2013 |
Bachhuber T, McCarter J, Tahirovic S, Nuscher B, Kamp F, Abou-Ajram C, Serrano-Pozo A, Hyman B, Haass C, Meyer-Luehmann M. Cross-inhibition of beta-amyloid plaque formation by alpha-synuclein Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1398 |
0.712 |
|
| 2013 |
Polydoro M, Hudry E, Perez-Nievas B, Arbel-Ornath M, Sanchez L, Spires-Jones T, Reumers V, Gómez-Isla T, Hyman B. P3-048: Caspase cleavage of tau is critical for oligomeric beta-amyloid-induced sub-lethal apoptotic cascade Alzheimer's & Dementia. 9: P568-P569. DOI: 10.1016/J.Jalz.2013.05.1117 |
0.8 |
|
| 2013 |
Kuchibhotla K, Wegmann S, Spires-Jones T, Bacskai B, Hyman B. O2-01-01: Neurofibrillary tangles remain functionally integrated in cortical networks Alzheimer's & Dementia. 9: P314-P314. DOI: 10.1016/J.Jalz.2013.04.135 |
0.768 |
|
| 2013 |
Hudry E, Arbel-Ornath M, Hashimoto T, Boivin J, Lattarulo C, Bacskai B, Hyman B. O1-01-03: Oligomeric soluble beta-amyloid species induce calcium dyshomeostasis in the healthy living mouse brain Alzheimer's & Dementia. 9: P126-P126. DOI: 10.1016/J.Jalz.2013.04.051 |
0.705 |
|
| 2012 |
Hashimoto T, Serrano-Pozo A, Hori Y, Adams KW, Takeda S, Banerji AO, Mitani A, Joyner D, Thyssen DH, Bacskai BJ, Frosch MP, Spires-Jones TL, Finn MB, Holtzman DM, Hyman BT. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid β peptide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 15181-92. PMID 23100439 DOI: 10.1523/Jneurosci.1542-12.2012 |
0.838 |
|
| 2012 |
Kopeikina KJ, Hyman BT, Spires-Jones TL. Soluble forms of tau are toxic in Alzheimer's disease. Translational Neuroscience. 3: 223-233. PMID 23029602 DOI: 10.2478/S13380-012-0032-Y |
0.857 |
|
| 2012 |
Rudinskiy N, Hawkes JM, Betensky RA, Eguchi M, Yamaguchi S, Spires-Jones TL, Hyman BT. Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer's disease. Nature Neuroscience. 15: 1422-9. PMID 22922786 DOI: 10.1038/Nn.3199 |
0.726 |
|
| 2012 |
Cao L, Schrank BR, Rodriguez S, Benz EG, Moulia TW, Rickenbacher GT, Gomez AC, Levites Y, Edwards SR, Golde TE, Hyman BT, Barnea G, Albers MW. Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo. Nature Communications. 3: 1009. PMID 22910355 DOI: 10.1038/Ncomms2013 |
0.403 |
|
| 2012 |
Tai HC, Serrano-Pozo A, Hashimoto T, Frosch MP, Spires-Jones TL, Hyman BT. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. The American Journal of Pathology. 181: 1426-35. PMID 22867711 DOI: 10.1016/J.Ajpath.2012.06.033 |
0.846 |
|
| 2012 |
Serrano-Pozo A, Mielke ML, Muzitansky A, Gómez-Isla T, Growdon JH, Bacskai BJ, Betensky RA, Frosch MP, Hyman BT. Stable size distribution of amyloid plaques over the course of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 71: 694-701. PMID 22805771 DOI: 10.1097/Nen.0B013E31825E77De |
0.831 |
|
| 2012 |
Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Hyman BT, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801 |
0.601 |
|
| 2012 |
William CM, Andermann ML, Goldey GJ, Roumis DK, Reid RC, Shatz CJ, Albers MW, Frosch MP, Hyman BT. Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8004-11. PMID 22674275 DOI: 10.1523/JNEUROSCI.5369-11.2012 |
0.536 |
|
| 2012 |
Klucken J, Poehler AM, Ebrahimi-Fakhari D, Schneider J, Nuber S, Rockenstein E, Schlötzer-Schrehardt U, Hyman BT, McLean PJ, Masliah E, Winkler J. Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway. Autophagy. 8: 754-66. PMID 22647715 DOI: 10.4161/Auto.19371 |
0.764 |
|
| 2012 |
Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/Brain/Aws127 |
0.835 |
|
| 2012 |
Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5298-309. PMID 22496575 DOI: 10.1523/Jneurosci.0227-12.2012 |
0.736 |
|
| 2012 |
Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, ... Hyman BT, et al. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. Journal of Neuropathology and Experimental Neurology. 71: 362-81. PMID 22487856 DOI: 10.1097/Nen.0B013E31825018F7 |
0.716 |
|
| 2012 |
Hudry E, Wu HY, Arbel-Ornath M, Hashimoto T, Matsouaka R, Fan Z, Spires-Jones TL, Betensky RA, Bacskai BJ, Hyman BT. Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3176-92. PMID 22378890 DOI: 10.1523/Jneurosci.6439-11.2012 |
0.835 |
|
| 2012 |
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of tau pathology in a model of early Alzheimer's disease. Neuron. 73: 685-97. PMID 22365544 DOI: 10.1016/J.Neuron.2011.11.033 |
0.845 |
|
| 2012 |
Hyman BT, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Carrillo MC, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Thies B, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 1-13. PMID 22265587 DOI: 10.1016/J.Jalz.2011.10.007 |
0.641 |
|
| 2012 |
Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, et al. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. 39: 209-19. PMID 22218879 DOI: 10.1007/S00259-011-2045-0 |
0.402 |
|
| 2012 |
Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, ... Hyman BT, et al. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathologica. 123: 1-11. PMID 22101365 DOI: 10.1007/S00401-011-0910-3 |
0.634 |
|
| 2012 |
Okereke OI, Pantoja-Galicia N, Copeland M, Hyman BT, Wanggaard T, Albert MS, Betensky RA, Blacker D. The SIST-M: predictive validity of a brief structured clinical dementia rating interview. Alzheimer Disease and Associated Disorders. 26: 225-31. PMID 21986342 DOI: 10.1097/Wad.0B013E318231Cd30 |
0.31 |
|
| 2012 |
DaRocha-Souto B, Coma M, Pérez-Nievas BG, Scotton TC, Siao M, Sánchez-Ferrer P, Hashimoto T, Fan Z, Hudry E, Barroeta I, Serenó L, RodrÃguez M, Sánchez MB, Hyman BT, Gómez-Isla T. Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease. Neurobiology of Disease. 45: 425-37. PMID 21945540 DOI: 10.1016/J.Nbd.2011.09.002 |
0.714 |
|
| 2012 |
Beyer AS, von Einem B, Schwanzar D, Keller IE, Hellrung A, Thal DR, Ingelsson M, Makarova A, Deng M, Chhabra ES, Pröpper C, Böckers TM, Hyman BT, von Arnim CA. Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-β precursor protein. Neurobiology of Aging. 33: 732-43. PMID 20674096 DOI: 10.1016/J.Neurobiolaging.2010.06.006 |
0.395 |
|
| 2012 |
de Calignon A, Polydoro M, Suárez-Calvet M, William C, Adamowicz DH, Kopeikina KJ, Pitstick R, Sahara N, Ashe KH, Carlson GA, Spires-Jones TL, Hyman BT. Propagation of Tau Pathology in a Model of Early Alzheimer's Disease Neuron. 76: 461. DOI: 10.1016/j.neuron.2012.10.005 |
0.746 |
|
| 2012 |
Desikan R, McEvoy L, Schork A, Thompson W, Brewer J, Van De Bunt M, Morris A, McCarthy M, Owen M, O'Donovan M, Williams J, Hyman B, Andreassen O, Dale A. O1-09-05: On genetic pleiotropy between Alzheimer's disease and cardiovascular risk factors Alzheimer's & Dementia. 8: P101-P102. DOI: 10.1016/J.Jalz.2012.05.255 |
0.323 |
|
| 2011 |
Serrano-Pozo A, Frosch MP, Masliah E, Hyman BT. Neuropathological alterations in Alzheimer disease. Cold Spring Harbor Perspectives in Medicine. 1: a006189. PMID 22229116 DOI: 10.1101/Cshperspect.A006189 |
0.814 |
|
| 2011 |
Koffie RM, Farrar CT, Saidi LJ, William CM, Hyman BT, Spires-Jones TL. Nanoparticles enhance brain delivery of blood-brain barrier-impermeable probes for in vivo optical and magnetic resonance imaging. Proceedings of the National Academy of Sciences of the United States of America. 108: 18837-42. PMID 22065785 DOI: 10.1073/Pnas.1111405108 |
0.791 |
|
| 2011 |
Desikan RS, McEvoy LK, Thompson WK, Holland D, Roddey JC, Blennow K, Aisen PS, Brewer JB, Hyman BT, Dale AM. Amyloid-β associated volume loss occurs only in the presence of phospho-tau. Annals of Neurology. 70: 657-61. PMID 22002658 DOI: 10.1002/Ana.22509 |
0.442 |
|
| 2011 |
Ebrahimi-Fakhari D, Cantuti-Castelvetri I, Fan Z, Rockenstein E, Masliah E, Hyman BT, McLean PJ, Unni VK. Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14508-20. PMID 21994367 DOI: 10.1523/Jneurosci.1560-11.2011 |
0.816 |
|
| 2011 |
Ding H, Sarokhan AK, Roderick SS, Bakshi R, Maher NE, Ashourian P, Kan CG, Chang S, Santarlasci A, Swords KE, Ravina BM, Hayes MT, Sohur US, Wills AM, Flaherty AW, ... ... Hyman BT, et al. Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study. Movement Disorders : Official Journal of the Movement Disorder Society. 26: 2283-6. PMID 21953863 DOI: 10.1002/Mds.23934 |
0.79 |
|
| 2011 |
Koffie RM, Hyman BT, Spires-Jones TL. Alzheimer's disease: synapses gone cold. Molecular Neurodegeneration. 6: 63. PMID 21871088 DOI: 10.1186/1750-1326-6-63 |
0.841 |
|
| 2011 |
Kopeikina KJ, Carlson GA, Pitstick R, Ludvigson AE, Peters A, Luebke JI, Koffie RM, Frosch MP, Hyman BT, Spires-Jones TL. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. The American Journal of Pathology. 179: 2071-82. PMID 21854751 DOI: 10.1016/J.Ajpath.2011.07.004 |
0.84 |
|
| 2011 |
Ranganathan S, Noyes NC, Migliorini M, Winkles JA, Battey FD, Hyman BT, Smith E, Yepes M, Mikhailenko I, Strickland DK. LRAD3, a novel low-density lipoprotein receptor family member that modulates amyloid precursor protein trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10836-46. PMID 21795536 DOI: 10.1523/Jneurosci.5065-10.2011 |
0.365 |
|
| 2011 |
Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, ... ... Hyman BT, et al. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 386-395.e6. PMID 21784349 DOI: 10.1016/J.Jalz.2011.05.2243 |
0.409 |
|
| 2011 |
Sperling RA, Jack CR, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, et al. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 367-85. PMID 21784348 DOI: 10.1016/J.Jalz.2011.05.2351 |
0.604 |
|
| 2011 |
Serrano-Pozo A, Mielke ML, Gómez-Isla T, Betensky RA, Growdon JH, Frosch MP, Hyman BT. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. The American Journal of Pathology. 179: 1373-84. PMID 21777559 DOI: 10.1016/J.Ajpath.2011.05.047 |
0.837 |
|
| 2011 |
Growdon JH, Hyman BT. Plasma beta-amyloid linked to cognitive decline. Archives of Neurology. 68: 799-801. PMID 21670404 DOI: 10.1001/Archneurol.2011.114 |
0.503 |
|
| 2011 |
Fox LM, William CM, Adamowicz DH, Pitstick R, Carlson GA, Spires-Jones TL, Hyman BT. Soluble tau species, not neurofibrillary aggregates, disrupt neural system integration in a tau transgenic model. Journal of Neuropathology and Experimental Neurology. 70: 588-95. PMID 21666499 DOI: 10.1097/Nen.0B013E318220A658 |
0.749 |
|
| 2011 |
Hashimoto T, Adams KW, Fan Z, McLean PJ, Hyman BT. Characterization of oligomer formation of amyloid-beta peptide using a split-luciferase complementation assay. The Journal of Biological Chemistry. 286: 27081-91. PMID 21652708 DOI: 10.1074/Jbc.M111.257378 |
0.837 |
|
| 2011 |
Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT. Are tangles as toxic as they look? Journal of Molecular Neuroscience : Mn. 45: 438-44. PMID 21638071 DOI: 10.1007/S12031-011-9566-7 |
0.846 |
|
| 2011 |
McKhann GM, Knopman DS, Chertkow H, Hyman BT, Jack CR, Kawas CH, Klunk WE, Koroshetz WJ, Manly JJ, Mayeux R, Mohs RC, Morris JC, Rossor MN, Scheltens P, Carrillo MC, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 263-9. PMID 21514250 DOI: 10.1016/J.Jalz.2011.03.005 |
0.438 |
|
| 2011 |
Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 76: 1395-402. PMID 21490323 DOI: 10.1212/Wnl.0B013E3182166E96 |
0.431 |
|
| 2011 |
DaRocha-Souto B, Scotton TC, Coma M, Serrano-Pozo A, Hashimoto T, Serenó L, RodrÃguez M, Sánchez B, Hyman BT, Gómez-Isla T. Brain oligomeric β-amyloid but not total amyloid plaque burden correlates with neuronal loss and astrocyte inflammatory response in amyloid precursor protein/tau transgenic mice. Journal of Neuropathology and Experimental Neurology. 70: 360-76. PMID 21487307 DOI: 10.1097/Nen.0B013E318217A118 |
0.831 |
|
| 2011 |
Hyman BT. Amyloid-dependent and amyloid-independent stages of Alzheimer disease. Archives of Neurology. 68: 1062-4. PMID 21482918 DOI: 10.1001/Archneurol.2011.70 |
0.496 |
|
| 2011 |
Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Hyman BT, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801 |
0.591 |
|
| 2011 |
Okereke OI, Copeland M, Hyman BT, Wanggaard T, Albert MS, Blacker D. The Structured Interview & Scoring Tool-Massachusetts Alzheimer's Disease Research Center (SIST-M): development, reliability, and cross-sectional validation of a brief structured clinical dementia rating interview. Archives of Neurology. 68: 343-50. PMID 21403019 DOI: 10.1001/Archneurol.2010.375 |
0.303 |
|
| 2011 |
Meyer-Luehmann M, Mora JR, Mielke M, Spires-Jones TL, de Calignon A, von Andrian UH, Hyman BT. T cell mediated cerebral hemorrhages and microhemorrhages during passive Aβ immunization in APPPS1 transgenic mice. Molecular Neurodegeneration. 6: 22. PMID 21388539 DOI: 10.1186/1750-1326-6-22 |
0.692 |
|
| 2011 |
Kalia LV, Kalia SK, Chau H, Lozano AM, Hyman BT, McLean PJ. Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5). Plos One. 6: e14695. PMID 21358815 DOI: 10.1371/Journal.Pone.0014695 |
0.8 |
|
| 2011 |
Jones PB, Adams KW, Rozkalne A, Spires-Jones TL, Hshieh TT, Hashimoto T, von Armin CA, Mielke M, Bacskai BJ, Hyman BT. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-β in human Alzheimer brain. Plos One. 6: e14586. PMID 21297948 DOI: 10.1371/Journal.Pone.0014586 |
0.829 |
|
| 2011 |
Hyman BT. Caspase activation without apoptosis: insight into Aβ initiation of neurodegeneration. Nature Neuroscience. 14: 5-6. PMID 21187847 DOI: 10.1038/Nn0111-5 |
0.339 |
|
| 2011 |
Unni VK, Ebrahimi-Fakhari D, Vanderburg CR, McLean PJ, Hyman BT. Studying protein degradation pathways in vivo using a cranial window-based approach. Methods (San Diego, Calif.). 53: 194-200. PMID 21187150 DOI: 10.1016/J.Ymeth.2010.12.032 |
0.812 |
|
| 2011 |
Spires-Jones TL, de Calignon A, Meyer-Luehmann M, Bacskai BJ, Hyman BT. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods (San Diego, Calif.). 53: 201-7. PMID 21163350 DOI: 10.1016/J.Ymeth.2010.12.009 |
0.821 |
|
| 2011 |
Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, et al. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic (Copenhagen, Denmark). 12: 330-48. PMID 21143716 DOI: 10.1111/J.1600-0854.2010.01149.X |
0.49 |
|
| 2011 |
Rozkalne A, Hyman BT, Spires-Jones TL. Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice. Neurobiology of Disease. 41: 650-4. PMID 21134458 DOI: 10.1016/J.Nbd.2010.11.014 |
0.725 |
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| 2011 |
Skoglund L, Matsui T, Freeman SH, Wallin A, Blom ES, Frosch MP, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A. Novel progranulin mutation detected in 2 patients with FTLD. Alzheimer Disease and Associated Disorders. 25: 173-8. PMID 20975516 DOI: 10.1097/Wad.0B013E3181Fbc22C |
0.585 |
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| 2011 |
Spires-Jones TL, Kay K, Matsouka R, Rozkalne A, Betensky RA, Hyman BT. Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. Neuroscience Letters. 487: 260-3. PMID 20970476 DOI: 10.1016/J.Neulet.2010.10.033 |
0.694 |
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| 2011 |
Danzer KM, Ruf WP, Putcha P, Joyner D, Hashimoto T, Glabe C, Hyman BT, McLean PJ. Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 326-36. PMID 20876215 DOI: 10.1096/Fj.10-164624 |
0.807 |
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| 2011 |
Holtzman D, Hyman B, Lee V, Spires-Jones T, Koffie R, Hashimoto T, Joyner D, Hou S, Kopeikina K, Frosch M. O1-05-01: APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease Alzheimer's & Dementia. 7: S103-S104. DOI: 10.1016/J.Jalz.2011.05.256 |
0.821 |
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| 2011 |
Wahlster L, Arimon M, Nasser-Ghodsi N, Serrano-Pozo A, Hyman B, Berezovska O. γ-Secretase conformational changes in the Alzheimer's Disease brain Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1636 |
0.745 |
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| 2011 |
Hudry E, Hashimoto T, Scheel M, Dashkoff J, Spires-Jones T, Bacskai B, Davidson B, Hyman B. P2-465: Changes in the progression of amyloid deposition in APP/PS mice after overexpression of different ApoE isoforms through intraventricular injection of an adeno-associated virus serotype 4 Alzheimer's & Dementia. 7: S461-S462. DOI: 10.1016/J.Jalz.2011.05.1337 |
0.81 |
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| 2011 |
Spires-Jones TL, Kopeikina KJ, Koffie RM, de Calignon A, Hyman BT. Erratum to: Are Tangles as Toxic as They Look? Journal of Molecular Neuroscience. 45: 742-742. DOI: 10.1007/S12031-011-9581-8 |
0.791 |
|
| 2010 |
Blom ES, Wang Y, Skoglund L, Hansson AC, Ubaldi M, Lourdusamy A, Sommer WH, Mielke M, Hyman BT, Heilig M, Lannfelt L, Nilsson LN, Ingelsson M. Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain. International Journal of Alzheimer's Disease. 2011: 936580. PMID 21234373 DOI: 10.4061/2011/936580 |
0.416 |
|
| 2010 |
Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nature Communications. 1: 130. PMID 21119643 DOI: 10.1038/Ncomms1129 |
0.613 |
|
| 2010 |
de Calignon A, Spires-Jones TL, Hyman BT. [Caspase activation precedes and leads to neurodegeneration in a murine model of Alzheimer's disease]. Mã©Decine Sciences : M/S. 26: 787-9. PMID 20929661 DOI: 10.1051/Medsci/20102610787 |
0.733 |
|
| 2010 |
Unni VK, Weissman TA, Rockenstein E, Masliah E, McLean PJ, Hyman BT. In vivo imaging of alpha-synuclein in mouse cortex demonstrates stable expression and differential subcellular compartment mobility. Plos One. 5: e10589. PMID 20485674 DOI: 10.1371/Journal.Pone.0010589 |
0.807 |
|
| 2010 |
Serrano-Pozo A, Vega GL, Lütjohann D, Locascio JJ, Tennis MK, Deng A, Atri A, Hyman BT, Irizarry MC, Growdon JH. Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers. Alzheimer Disease and Associated Disorders. 24: 220-6. PMID 20473136 DOI: 10.1097/Wad.0B013E3181D61Fea |
0.79 |
|
| 2010 |
Serrano-Pozo A, William CM, Ferrer I, Uro-Coste E, Delisle MB, Maurage CA, Hock C, Nitsch RM, Masliah E, Growdon JH, Frosch MP, Hyman BT. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain : a Journal of Neurology. 133: 1312-27. PMID 20360050 DOI: 10.1093/Brain/Awq056 |
0.818 |
|
| 2010 |
de Calignon A, Fox LM, Pitstick R, Carlson GA, Bacskai BJ, Spires-Jones TL, Hyman BT. Caspase activation precedes and leads to tangles. Nature. 464: 1201-4. PMID 20357768 DOI: 10.1038/Nature08890 |
0.81 |
|
| 2010 |
Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. Plos One. 5: e9505. PMID 20209079 DOI: 10.1371/Journal.Pone.0009505 |
0.46 |
|
| 2010 |
Wu HY, Hudry E, Hashimoto T, Kuchibhotla K, Rozkalne A, Fan Z, Spires-Jones T, Xie H, Arbel-Ornath M, Grosskreutz CL, Bacskai BJ, Hyman BT. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 2636-49. PMID 20164348 DOI: 10.1523/Jneurosci.4456-09.2010 |
0.84 |
|
| 2010 |
Coma M, Serenó L, Da Rocha-Souto B, Scotton TC, España J, Sánchez MB, RodrÃguez M, Agulló J, Guardia-Laguarta C, Garcia-Alloza M, Borrelli LA, Clarimón J, Lleó A, Bacskai BJ, Saura CA, ... Hyman BT, et al. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 38: 482-91. PMID 20149872 DOI: 10.1016/J.Nbd.2010.01.019 |
0.647 |
|
| 2010 |
Putcha P, Danzer KM, Kranich LR, Scott A, Silinski M, Mabbett S, Hicks CD, Veal JM, Steed PM, Hyman BT, McLean PJ. Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity. The Journal of Pharmacology and Experimental Therapeutics. 332: 849-57. PMID 19934398 DOI: 10.1124/Jpet.109.158436 |
0.803 |
|
| 2010 |
Hillmer AS, Putcha P, Levin J, Högen T, Hyman BT, Kretzschmar H, McLean PJ, Giese A. Converse modulation of toxic alpha-synuclein oligomers in living cells by N'-benzylidene-benzohydrazide derivates and ferric iron. Biochemical and Biophysical Research Communications. 391: 461-6. PMID 19914207 DOI: 10.1016/J.Bbrc.2009.11.080 |
0.741 |
|
| 2010 |
Fukumoto N, Fujii T, Combarros O, Kamboh MI, Tsai SJ, Matsushita S, Nacmias B, Comings DE, Arboleda H, Ingelsson M, Hyman BT, Akatsu H, Grupe A, Nishimura AL, Zatz M, et al. Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 235-42. PMID 19504537 DOI: 10.1002/Ajmg.B.30986 |
0.366 |
|
| 2010 |
Garcia-Alloza M, Borrelli LA, Hyman BT, Bacskai BJ. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiology of Aging. 31: 2058-68. PMID 19124175 DOI: 10.1016/J.Neurobiolaging.2008.11.006 |
0.635 |
|
| 2010 |
Hyman BT, de Calignon A, Suarez-Calvet M, William C, Pitstick R, Carlson GA, Spires-Jones TL. PL-05-01: A transgenic model of the earliest stage of Alzheimer's disease Alzheimer's & Dementia. 6: S165-S165. DOI: 10.1016/J.Jalz.2010.05.513 |
0.726 |
|
| 2010 |
Bacskai BJ, Kuchibhotla KV, Lattarulo C, Hyman BT. Dysregulation of Intracellular Calcium in Alzheimer's Disease Biophysical Journal. 98: 3a. DOI: 10.1016/J.Bpj.2009.12.015 |
0.602 |
|
| 2009 |
Skoglund L, Ingvast S, Matsui T, Freeman SH, Frosch MP, Brundin R, Giedraitis V, Growdon JH, Hyman BT, Lannfelt L, Ingelsson M, Glaser A. No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration. Dementia and Geriatric Cognitive Disorders. 28: 471-5. PMID 19940479 DOI: 10.1159/000260046 |
0.648 |
|
| 2009 |
Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. Plos One. 4: e7893. PMID 19924286 DOI: 10.1371/Journal.Pone.0007893 |
0.605 |
|
| 2009 |
Chen L, Periquet M, Wang X, Negro A, McLean PJ, Hyman BT, Feany MB. Tyrosine and serine phosphorylation of alpha-synuclein have opposing effects on neurotoxicity and soluble oligomer formation. The Journal of Clinical Investigation. 119: 3257-65. PMID 19855133 DOI: 10.1172/Jci39088 |
0.74 |
|
| 2009 |
Meyer-Luehmann M, Mielke M, Spires-Jones TL, Stoothoff W, Jones P, Bacskai BJ, Hyman BT. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12636-40. PMID 19812338 DOI: 10.1523/Jneurosci.1948-09.2009 |
0.772 |
|
| 2009 |
Outeiro TF, Klucken J, Bercury K, Tetzlaff J, Putcha P, Oliveira LM, Quintas A, McLean PJ, Hyman BT. Dopamine-induced conformational changes in alpha-synuclein. Plos One. 4: e6906. PMID 19730729 DOI: 10.1371/Journal.Pone.0006906 |
0.798 |
|
| 2009 |
Stoothoff W, Jones PB, Spires-Jones TL, Joyner D, Chhabra E, Bercury K, Fan Z, Xie H, Bacskai B, Edd J, Irimia D, Hyman BT. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. Journal of Neurochemistry. 111: 417-27. PMID 19686388 DOI: 10.1111/J.1471-4159.2009.06316.X |
0.81 |
|
| 2009 |
Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63: 178-88. PMID 19640477 DOI: 10.1016/J.Neuron.2009.07.003 |
0.444 |
|
| 2009 |
de Calignon A, Spires-Jones TL, Pitstick R, Carlson GA, Hyman BT. Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy. Journal of Neuropathology and Experimental Neurology. 68: 757-61. PMID 19535996 DOI: 10.1097/Nen.0B013E3181A9Fc66 |
0.723 |
|
| 2009 |
McFarland NR, Fan Z, Xu K, Schwarzschild MA, Feany MB, Hyman BT, McLean PJ. Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease. Journal of Neuropathology and Experimental Neurology. 68: 515-24. PMID 19525899 DOI: 10.1097/Nen.0B013E3181A24B53 |
0.801 |
|
| 2009 |
Hoe HS, Lee KJ, Carney RS, Lee J, Markova A, Lee JY, Howell BW, Hyman BT, Pak DT, Bu G, Rebeck GW. Interaction of reelin with amyloid precursor protein promotes neurite outgrowth. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7459-73. PMID 19515914 DOI: 10.1523/Jneurosci.4872-08.2009 |
0.642 |
|
| 2009 |
Rozkalne A, Spires-Jones TL, Stern EA, Hyman BT. A single dose of passive immunotherapy has extended benefits on synapses and neurites in an Alzheimer's disease mouse model. Brain Research. 1280: 178-85. PMID 19465012 DOI: 10.1016/J.Brainres.2009.05.045 |
0.766 |
|
| 2009 |
Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. Journal of Neurochemistry. 110: 220-30. PMID 19457132 DOI: 10.1111/J.1471-4159.2009.06126.X |
0.344 |
|
| 2009 |
Blom ES, Giedraitis V, Zetterberg H, Fukumoto H, Blennow K, Hyman BT, Irizarry MC, Wahlund LO, Lannfelt L, Ingelsson M. Rapid progression from mild cognitive impairment to Alzheimer's disease in subjects with elevated levels of tau in cerebrospinal fluid and the APOE epsilon4/epsilon4 genotype. Dementia and Geriatric Cognitive Disorders. 27: 458-64. PMID 19420940 DOI: 10.1159/000216841 |
0.482 |
|
| 2009 |
Garcia-Alloza M, Subramanian M, Thyssen D, Borrelli LA, Fauq A, Das P, Golde TE, Hyman BT, Bacskai BJ. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Molecular Neurodegeneration. 4: 19. PMID 19419556 DOI: 10.1186/1750-1326-4-19 |
0.646 |
|
| 2009 |
Fischl B, Stevens AA, Rajendran N, Yeo BT, Greve DN, Van Leemput K, Polimeni JR, Kakunoori S, Buckner RL, Pacheco J, Salat DH, Melcher J, Frosch MP, Hyman BT, Grant PE, et al. Predicting the location of entorhinal cortex from MRI. Neuroimage. 47: 8-17. PMID 19376238 DOI: 10.1016/J.Neuroimage.2009.04.033 |
0.564 |
|
| 2009 |
Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, et al. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science (New York, N.Y.). 324: 639-42. PMID 19299585 DOI: 10.1126/Science.1171176 |
0.42 |
|
| 2009 |
Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Molecular and Cellular Neurosciences. 41: 166-74. PMID 19281847 DOI: 10.1016/J.Mcn.2009.02.008 |
0.408 |
|
| 2009 |
Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science (New York, N.Y.). 323: 1211-5. PMID 19251629 DOI: 10.1126/Science.1169096 |
0.62 |
|
| 2009 |
McFarland NR, Lee JS, Hyman BT, McLean PJ. Comparison of transduction efficiency of recombinant AAV serotypes 1, 2, 5, and 8 in the rat nigrostriatal system. Journal of Neurochemistry. 109: 838-45. PMID 19250335 DOI: 10.1111/J.1471-4159.2009.06010.X |
0.803 |
|
| 2009 |
Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/Pnas.0811698106 |
0.828 |
|
| 2009 |
Okereke OI, Xia W, Irizarry MC, Sun X, Qiu WQ, Fagan AM, Mehta PD, Hyman BT, Selkoe DJ, Grodstein F. Performance characteristics of plasma amyloid-beta 40 and 42 assays. Journal of Alzheimer's Disease : Jad. 16: 277-85. PMID 19221417 DOI: 10.3233/Jad-2009-0948 |
0.377 |
|
| 2009 |
Hoe HS, Fu Z, Makarova A, Lee JY, Lu C, Feng L, Pajoohesh-Ganji A, Matsuoka Y, Hyman BT, Ehlers MD, Vicini S, Pak DT, Rebeck GW. The effects of amyloid precursor protein on postsynaptic composition and activity. The Journal of Biological Chemistry. 284: 8495-506. PMID 19164281 DOI: 10.1074/Jbc.M900141200 |
0.615 |
|
| 2009 |
Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT. Tau pathophysiology in neurodegeneration: a tangled issue. Trends in Neurosciences. 32: 150-9. PMID 19162340 DOI: 10.1016/J.Tins.2008.11.007 |
0.753 |
|
| 2009 |
Desikan RS, Cabral HJ, Fischl B, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease. Ajnr. American Journal of Neuroradiology. 30: 532-8. PMID 19112067 DOI: 10.3174/Ajnr.A1397 |
0.38 |
|
| 2009 |
Spoelgen R, Adams KW, Koker M, Thomas AV, Andersen OM, Hallett PJ, Bercury KK, Joyner DF, Deng M, Stoothoff WH, Strickland DK, Willnow TE, Hyman BT. Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11. Neuroscience. 158: 1460-8. PMID 19047013 DOI: 10.1016/J.Neuroscience.2008.10.061 |
0.779 |
|
| 2009 |
Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. Journal of Neurochemistry. 108: 350-60. PMID 19046403 DOI: 10.1111/J.1471-4159.2008.05760.X |
0.358 |
|
| 2009 |
Spires-Jones TL, Mielke ML, Rozkalne A, Meyer-Luehmann M, de Calignon A, Bacskai BJ, Schenk D, Hyman BT. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiology of Disease. 33: 213-20. PMID 19028582 DOI: 10.1016/J.Nbd.2008.10.011 |
0.805 |
|
| 2009 |
Lu A, Hiltunen M, Romano DM, Soininen H, Hyman BT, Bertram L, Tanzi RE. Effects of ubiquilin 1 on the unfolded protein response. Journal of Molecular Neuroscience : Mn. 38: 19-30. PMID 18953672 DOI: 10.1007/S12031-008-9155-6 |
0.365 |
|
| 2009 |
Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, et al. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cerebral Cortex (New York, N.Y. : 1991). 19: 497-510. PMID 18632739 DOI: 10.1093/Cercor/Bhn113 |
0.6 |
|
| 2009 |
Freeman SH, Hyman BT, Sims KB, Hedley-Whyte ET, Vossough A, Frosch MP, Schmahmann JD. Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations. Brain Pathology (Zurich, Switzerland). 19: 39-47. PMID 18422757 DOI: 10.1111/J.1750-3639.2008.00163.X |
0.636 |
|
| 2009 |
Philipson O, Hammarström P, Nilsson KP, Portelius E, Olofsson T, Ingelsson M, Hyman BT, Blennow K, Lannfelt L, Kalimo H, Nilsson LN. A highly insoluble state of Abeta similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice. Neurobiology of Aging. 30: 1393-405. PMID 18192084 DOI: 10.1016/J.Neurobiolaging.2007.11.022 |
0.44 |
|
| 2009 |
Jones PB, Bacskai BJ, Hyman BT. Chapter 11 Biomedical FRET-FLIM applications Laboratory Techniques in Biochemistry and Molecular Biology. 33: 447-474. DOI: 10.1016/S0075-7535(08)00011-9 |
0.401 |
|
| 2008 |
Stoothoff WH, Bacskai BJ, Hyman BT. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. Journal of Biomedical Optics. 13: 064039. PMID 19123685 DOI: 10.1117/1.3050422 |
0.622 |
|
| 2008 |
Koenigsknecht-Talboo J, Meyer-Luehmann M, Parsadanian M, Garcia-Alloza M, Finn MB, Hyman BT, Bacskai BJ, Holtzman DM. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 14156-64. PMID 19109498 DOI: 10.1523/Jneurosci.4147-08.2008 |
0.632 |
|
| 2008 |
Mandal AK, Jones PB, Bair AM, Christmas P, Miller D, Yamin TT, Wisniewski D, Menke J, Evans JF, Hyman BT, Bacskai B, Chen M, Lee DM, Nikolic B, Soberman RJ. The nuclear membrane organization of leukotriene synthesis. Proceedings of the National Academy of Sciences of the United States of America. 105: 20434-9. PMID 19075240 DOI: 10.1073/Pnas.0808211106 |
0.495 |
|
| 2008 |
Freeman SH, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Locascio JJ, Lipsitz LA, Hyman BT. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 67: 1205-12. PMID 19018241 DOI: 10.1097/Nen.0B013E31818Fc72F |
0.686 |
|
| 2008 |
Grodstein F, van Oijen M, Irizarry MC, Rosas HD, Hyman BT, Growdon JH, De Vivo I. Shorter telomeres may mark early risk of dementia: preliminary analysis of 62 participants from the nurses' health study. Plos One. 3: e1590. PMID 18795148 DOI: 10.1371/Journal.Pone.0001590 |
0.516 |
|
| 2008 |
Gomperts SN, Rentz DM, Moran E, Becker JA, Locascio JJ, Klunk WE, Mathis CA, Elmaleh DR, Shoup T, Fischman AJ, Hyman BT, Growdon JH, Johnson KA. Imaging amyloid deposition in Lewy body diseases. Neurology. 71: 903-10. PMID 18794492 DOI: 10.1212/01.Wnl.0000326146.60732.D6 |
0.619 |
|
| 2008 |
Hyman B. In reply to Zou et al. "New amyloid plaques or a game of hide-and-seek?". International Journal of Biological Sciences. 4: 245. PMID 18726000 DOI: 10.7150/Ijbs.4.245 |
0.317 |
|
| 2008 |
Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD. Neurology. 71: 819-25. PMID 18672473 DOI: 10.1212/01.Wnl.0000320055.57329.34 |
0.372 |
|
| 2008 |
Kuchibhotla KV, Goldman ST, Lattarulo CR, Wu HY, Hyman BT, Bacskai BJ. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 59: 214-25. PMID 18667150 DOI: 10.1016/J.Neuron.2008.06.008 |
0.612 |
|
| 2008 |
Khachaturian ZS, Petersen RC, Gauthier S, Buckholtz N, Corey-Bloom JP, Evans B, Fillit H, Foster N, Greenberg B, Grundman M, Sano M, Simpkins J, Schneider LS, Weiner MW, Galasko D, ... Hyman B, et al. A roadmap for the prevention of dementia: the inaugural Leon Thal Symposium. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 156-63. PMID 18631960 DOI: 10.1016/J.Jalz.2008.03.005 |
0.369 |
|
| 2008 |
Gomez-Isla T, Spires T, De Calignon A, Hyman BT. Neuropathology of Alzheimer's disease. Handbook of Clinical Neurology. 89: 233-43. PMID 18631748 DOI: 10.1016/S0072-9752(07)01222-5 |
0.376 |
|
| 2008 |
Steinerman JR, Irizarry M, Scarmeas N, Raju S, Brandt J, Albert M, Blacker D, Hyman B, Stern Y. Distinct pools of beta-amyloid in Alzheimer disease-affected brain: a clinicopathologic study. Archives of Neurology. 65: 906-12. PMID 18625856 DOI: 10.1001/Archneur.65.7.906 |
0.435 |
|
| 2008 |
Makarova A, Bercury KK, Adams KW, Joyner D, Deng M, Spoelgen R, Koker M, Strickland DK, Hyman BT. The LDL receptor-related protein can form homo-dimers in neuronal cells. Neuroscience Letters. 442: 91-5. PMID 18602448 DOI: 10.1016/J.Neulet.2008.06.070 |
0.78 |
|
| 2008 |
Locascio JJ, Fukumoto H, Yap L, Bottiglieri T, Growdon JH, Hyman BT, Irizarry MC. Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. Archives of Neurology. 65: 776-85. PMID 18541797 DOI: 10.1001/Archneur.65.6.776 |
0.576 |
|
| 2008 |
Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. CHIP targets toxic alpha-Synuclein oligomers for degradation. The Journal of Biological Chemistry. 283: 17962-8. PMID 18436529 DOI: 10.1074/Jbc.M802283200 |
0.802 |
|
| 2008 |
O'Callaghan P, Sandwall E, Li JP, Yu H, Ravid R, Guan ZZ, van Kuppevelt TH, Nilsson LN, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. Brain Pathology (Zurich, Switzerland). 18: 548-61. PMID 18422760 DOI: 10.1111/J.1750-3639.2008.00152.X |
0.454 |
|
| 2008 |
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric alpha-synuclein species in living cells. Plos One. 3: e1867. PMID 18382657 DOI: 10.1371/Journal.Pone.0001867 |
0.794 |
|
| 2008 |
Thomas AV, Berezovska O, Hyman BT, von Arnim CA. Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. Methods (San Diego, Calif.). 44: 299-303. PMID 18374273 DOI: 10.1016/J.Ymeth.2007.02.003 |
0.481 |
|
| 2008 |
Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. Journal of Biomedical Optics. 13: 014008. PMID 18315366 DOI: 10.1117/1.2837169 |
0.699 |
|
| 2008 |
Sundelöf J, Giedraitis V, Irizarry MC, Sundström J, Ingelsson E, Rönnemaa E, Arnlöv J, Gunnarsson MD, Hyman BT, Basun H, Ingelsson M, Lannfelt L, Kilander L. Plasma beta amyloid and the risk of Alzheimer disease and dementia in elderly men: a prospective, population-based cohort study. Archives of Neurology. 65: 256-63. PMID 18268197 DOI: 10.1001/Archneurol.2007.57 |
0.452 |
|
| 2008 |
Meyer-Luehmann M, Spires-Jones TL, Prada C, Garcia-Alloza M, de Calignon A, Rozkalne A, Koenigsknecht-Talboo J, Holtzman DM, Bacskai BJ, Hyman BT. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 451: 720-4. PMID 18256671 DOI: 10.1038/Nature06616 |
0.826 |
|
| 2008 |
Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/Jneurosci.3072-08.2008 |
0.764 |
|
| 2008 |
Yacoubian TA, Cantuti-Castelvetri I, Bouzou B, Asteris G, McLean PJ, Hyman BT, Standaert DG. Transcriptional dysregulation in a transgenic model of Parkinson disease. Neurobiology of Disease. 29: 515-28. PMID 18191405 DOI: 10.1016/J.Nbd.2007.11.008 |
0.727 |
|
| 2008 |
Freeman SH, Spires-Jones T, Hyman BT, Growdon JH, Frosch MP. TAR-DNA binding protein 43 in Pick disease. Journal of Neuropathology and Experimental Neurology. 67: 62-7. PMID 18091558 DOI: 10.1097/Nen.0B013E3181609361 |
0.812 |
|
| 2008 |
Hoe HS, Minami SS, Makarova A, Lee J, Hyman BT, Matsuoka Y, Rebeck GW. Fyn modulation of Dab1 effects on amyloid precursor protein and ApoE receptor 2 processing. The Journal of Biological Chemistry. 283: 6288-99. PMID 18089558 DOI: 10.1074/Jbc.M704140200 |
0.798 |
|
| 2008 |
Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Correction: Formation of Toxic Oligomeric α-Synuclein Species in Living Cells Plos One. 3. DOI: 10.1371/Annotation/9282F173-Df82-4B70-9120-B4E62B3Dacb1 |
0.775 |
|
| 2008 |
Stoothoff WH, Hyman BT. P4-256: Monitoring of tau-tubulin interactions with second harmonic generation Alzheimer's & Dementia. 4: T746-T746. DOI: 10.1016/J.Jalz.2008.05.2325 |
0.302 |
|
| 2008 |
Freeman S, Kandel R, Cruz L, Rozkalne A, Newell K, Frosch MP, Hedley-Whyte ET, Lipsitz L, Hyman BT. P4-154: Neuronal atrophy and neuropil loss, rather than neuronal loss, underlies age-related cortical brain atrophy in elderly subjects without Alzheimer's disease Alzheimer's & Dementia. 4: T715-T715. DOI: 10.1016/J.Jalz.2008.05.2221 |
0.573 |
|
| 2008 |
Sundelöf JE, Ärnlöv J, Ingelsson E, Sundström J, Basu S, Zethelius B, Larsson A, Irizarry MC, Giedraitis V, Rönnemaa E, Degerman-Gunnarsson M, Hyman BT, Basun H, Kilander L, Lannfelt L. P4-108: Serum cystatin C and the risk of Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.2174 |
0.353 |
|
| 2008 |
Callaghan PO, Sandwall E, Li J, Yu H, Ravid R, Guan Z, Kuppevelt THv, Nilsson LNG, Ingelsson M, Hyman BT, Kalimo H, Lindahl U, Lannfelt L, Zhang X. P3-416: Aβ stimulation leads to elevated levels of heparan sulfate proteoglycans in glial cells Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1987 |
0.309 |
|
| 2008 |
Blom ES, Wang Y, Hansson A, Sommer W, Hyman BT, Heilig M, Lannfelt L, Nisson LNG, Ingelsson M. P3-205: Upregulation of genes in the Wnt pathway in tg-ArcSwe mice and Alzheimer's disease brain Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1772 |
0.401 |
|
| 2008 |
Ingelsson M, Blom E, Zetterberg H, Fukumoto H, Hyman BT, Irizarry MC, Blennow K, Wahlund L, Lannfelt L. P3-076: CSF Tau levels and APOEϵ4 carriership predict the progression of mild cognitive impairment to Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1640 |
0.405 |
|
| 2008 |
Kowa H, Matsui T, Bouzou B, Clark T, Freeman S, Frosch M, Hyman B. P2-194: Complement pathways are upregulated in angular gyrus of primary progressive aphasia cases Alzheimer's & Dementia. 4: T427-T428. DOI: 10.1016/J.Jalz.2008.05.1268 |
0.449 |
|
| 2008 |
de Calignon A, Spires-Jones T, Hyman BT. P2-164: In vivo
multiphoton imaging of neurofibrillary tangles: Relationship to cell death cascades Alzheimer's & Dementia. 4: T418-T418. DOI: 10.1016/J.Jalz.2008.05.1238 |
0.671 |
|
| 2008 |
Meyer-Luehmann M, Stoothoff W, Spires-Jones TL, Kowa T, Koker M, Han K, Hyman BT. P1-486: Decreased neuronal activity in APP transgenic mice measured via dendritic protein synthesis Alzheimer's & Dementia. 4: T362-T362. DOI: 10.1016/J.Jalz.2008.05.1069 |
0.693 |
|
| 2008 |
Kuchibhotla KV, Goldman ST, Lattarulo CR, Hyman BT, Bacskai BJ. P1-473: Aβ disrupts spinodendritic calcium regulation in vivo Alzheimer's & Dementia. 4: T358-T358. DOI: 10.1016/J.Jalz.2008.05.1056 |
0.542 |
|
| 2007 |
Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Archives of General Psychiatry. 64: 1443-50. PMID 18056553 DOI: 10.1001/Archpsyc.64.12.1443 |
0.344 |
|
| 2007 |
Giedraitis V, Sundelöf J, Irizarry MC, Gårevik N, Hyman BT, Wahlund LO, Ingelsson M, Lannfelt L. The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease. Neuroscience Letters. 427: 127-31. PMID 17936506 DOI: 10.1016/J.Neulet.2007.09.023 |
0.426 |
|
| 2007 |
Irizarry MC, Yao Y, Hyman BT, Growdon JH, Praticò D. Plasma F2A isoprostane levels in Alzheimer's and Parkinson's disease. Neuro-Degenerative Diseases. 4: 403-5. PMID 17934322 DOI: 10.1159/000107699 |
0.576 |
|
| 2007 |
Garcia-Alloza M, Ferrara BJ, Dodwell SA, Hickey GA, Hyman BT, Bacskai BJ. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiology of Disease. 28: 286-92. PMID 17822910 DOI: 10.1016/J.Nbd.2007.07.019 |
0.63 |
|
| 2007 |
Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, Hubbard JL, Koepsell TD, Morris JC, Kukull WA, Reiman EM, Kowall N, Landreth G, Shelanski M, Welsh-Bohmer K, ... ... Hyman B, et al. The National Alzheimer's Coordinating Center (NACC) database: The uniform data set Alzheimer Disease and Associated Disorders. 21: 249-258. PMID 17804958 DOI: 10.1097/Wad.0B013E318142774E |
0.312 |
|
| 2007 |
Conrad C, Zhu J, Conrad C, Schoenfeld D, Fang Z, Ingelsson M, Stamm S, Church G, Hyman BT. Single molecule profiling of tau gene expression in Alzheimer's disease. Journal of Neurochemistry. 103: 1228-36. PMID 17727636 DOI: 10.1111/J.1471-4159.2007.04857.X |
0.542 |
|
| 2007 |
Ingelsson M, Ramasamy K, Russ C, Freeman SH, Orne J, Raju S, Matsui T, Growdon JH, Frosch MP, Ghetti B, Brown RH, Irizarry MC, Hyman BT. Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta Neuropathologica. 114: 471-9. PMID 17721707 DOI: 10.1007/S00401-007-0280-Z |
0.692 |
|
| 2007 |
Spires-Jones TL, Meyer-Luehmann M, Osetek JD, Jones PB, Stern EA, Bacskai BJ, Hyman BT. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. The American Journal of Pathology. 171: 1304-11. PMID 17717139 DOI: 10.2353/Ajpath.2007.070055 |
0.794 |
|
| 2007 |
Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain : a Journal of Neurology. 130: 2310-9. PMID 17638859 DOI: 10.1093/Brain/Awm156 |
0.687 |
|
| 2007 |
Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.). 317: 516-9. PMID 17588900 DOI: 10.1126/Science.1143780 |
0.734 |
|
| 2007 |
Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Research. 1161: 116-23. PMID 17586478 DOI: 10.1016/J.Brainres.2007.05.050 |
0.615 |
|
| 2007 |
Garcia-Alloza M, Borrelli LA, Rozkalne A, Hyman BT, Bacskai BJ. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. Journal of Neurochemistry. 102: 1095-104. PMID 17472706 DOI: 10.1111/J.1471-4159.2007.04613.X |
0.662 |
|
| 2007 |
Outeiro TF, Grammatopoulos TN, Altmann S, Amore A, Standaert DG, Hyman BT, Kazantsev AG. Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. Biochemical and Biophysical Research Communications. 357: 596-602. PMID 17449015 DOI: 10.1016/J.Bbrc.2007.03.163 |
0.318 |
|
| 2007 |
Freeman SH, Raju S, Hyman BT, Frosch MP, Irizarry MC. Plasma Abeta levels do not reflect brain Abeta levels. Journal of Neuropathology and Experimental Neurology. 66: 264-71. PMID 17413317 DOI: 10.1097/Nen.0B013E31803D3Ae4 |
0.577 |
|
| 2007 |
Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Archives of Neurology. 64: 431-4. PMID 17353389 DOI: 10.1001/Archneur.64.3.431 |
0.746 |
|
| 2007 |
Kim M, Hersh LB, Leissring MA, Ingelsson M, Matsui T, Farris W, Lu A, Hyman BT, Selkoe DJ, Bertram L, Tanzi RE. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. The Journal of Biological Chemistry. 282: 7825-32. PMID 17244626 DOI: 10.1074/Jbc.M609168200 |
0.394 |
|
| 2007 |
St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of Neurochemistry. 100: 1449-57. PMID 17241127 DOI: 10.1111/J.1471-4159.2006.04310.X |
0.749 |
|
| 2007 |
Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biology. 9: 139-48. PMID 17187063 DOI: 10.1038/Ncb1528 |
0.467 |
|
| 2007 |
Klucken J, McLean P, Hyman B, Bogdahn U, Winkler J. Chaperon Proteine steuern die alpha-Synuclein Aggregation und Degradation Aktuelle Neurologie. 34. DOI: 10.1055/S-2007-987900 |
0.717 |
|
| 2007 |
Meyer-Lühmann M, Hyman B, Jucker M. S.19.03 Exploring the early pathogenesis in Alzheimer's disease: insights from transgenic mouse models European Neuropsychopharmacology. 17: S205. DOI: 10.1016/S0924-977X(07)70249-3 |
0.306 |
|
| 2007 |
Desikan RS, Fischl B, Cabral HJ, Kemper TL, Guttmann CR, Blacker D, Hyman BT, Albert MS, Killiany RJ. P-030: MRI-based longitudinal measures of temporoparietal regions show differential rates of atrophy during prodromal Alzheimer's disease Alzheimer's & Dementia. 3: S106-S106. DOI: 10.1016/J.Jalz.2007.04.246 |
0.364 |
|
| 2007 |
Outeiro TF, McLean PJ, Hyman BT. Protein aggregation disorders Neurobiology of Disease. 111-123. DOI: 10.1016/B978-012088592-3/50012-8 |
0.773 |
|
| 2006 |
Hyman BT. The natural history of Alzheimer disease dissected through multiphoton imaging of transgenic mice. Alzheimer Disease and Associated Disorders. 20: 206-9. PMID 17132963 DOI: 10.1097/01.Wad.0000213850.51495.0F |
0.382 |
|
| 2006 |
Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. Journal of Biomedical Optics. 11: 054024. PMID 17092173 DOI: 10.1117/1.2363367 |
0.553 |
|
| 2006 |
Garcia-Alloza M, Dodwell SA, Meyer-Luehmann M, Hyman BT, Bacskai BJ. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. Journal of Neuropathology and Experimental Neurology. 65: 1082-9. PMID 17086105 DOI: 10.1097/01.Jnen.0000240468.12543.Af |
0.617 |
|
| 2006 |
Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochemical and Biophysical Research Communications. 351: 631-8. PMID 17081499 DOI: 10.1016/J.Bbrc.2006.10.085 |
0.751 |
|
| 2006 |
Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT. Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2050-7. PMID 17012257 DOI: 10.1096/Fj.05-5422Com |
0.714 |
|
| 2006 |
von Arnim CA, Spoelgen R, Peltan ID, Deng M, Courchesne S, Koker M, Matsui T, Kowa H, Lichtenthaler SF, Irizarry MC, Hyman BT. GGA1 acts as a spatial switch altering amyloid precursor protein trafficking and processing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9913-22. PMID 17005855 DOI: 10.1523/Jneurosci.2290-06.2006 |
0.405 |
|
| 2006 |
Sever S, Skoch J, Newmyer S, Ramachandran R, Ko D, McKee M, Bouley R, Ausiello D, Hyman BT, Bacskai BJ. Physical and functional connection between auxilin and dynamin during endocytosis. The Embo Journal. 25: 4163-74. PMID 16946707 DOI: 10.1038/Sj.Emboj.7601298 |
0.506 |
|
| 2006 |
Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. The Journal of Biological Chemistry. 281: 32240-53. PMID 16945923 DOI: 10.1074/Jbc.M603106200 |
0.438 |
|
| 2006 |
Peltan ID, Thomas AV, Mikhailenko I, Strickland DK, Hyman BT, von Arnim CA. Fluorescence lifetime imaging microscopy (FLIM) detects stimulus-dependent phosphorylation of the low density lipoprotein receptor-related protein (LRP) in primary neurons. Biochemical and Biophysical Research Communications. 349: 24-30. PMID 16930548 DOI: 10.1016/J.Bbrc.2006.07.212 |
0.33 |
|
| 2006 |
Skoch J, Hyman BT, Bacskai BJ. Preclinical characterization of amyloid imaging probes with multiphoton microscopy. Journal of Alzheimer's Disease : Jad. 9: 401-7. PMID 16914878 DOI: 10.3233/Jad-2006-9S345 |
0.602 |
|
| 2006 |
Hyman BT, Growdon JH. Can the immune system fight Alzheimer disease? Nature Medicine. 12: 755-6; discussion 75. PMID 16829929 DOI: 10.1038/Nm0706-755 |
0.549 |
|
| 2006 |
Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. The Journal of Biological Chemistry. 281: 26400-7. PMID 16815845 DOI: 10.1074/Jbc.M601085200 |
0.424 |
|
| 2006 |
Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, ... ... Hyman BT, et al. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathologica. 112: 439-49. PMID 16802167 DOI: 10.1007/S00401-006-0095-3 |
0.717 |
|
| 2006 |
Matsui T, Ramasamy K, Ingelsson M, Fukumoto H, Conrad C, Frosch MP, Irizarry MC, Yuan J, Hyman BT. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. Journal of Neuropathology and Experimental Neurology. 65: 508-15. PMID 16772874 DOI: 10.1097/01.Jnen.0000229238.05748.12 |
0.595 |
|
| 2006 |
Spires TL, Orne JD, SantaCruz K, Pitstick R, Carlson GA, Ashe KH, Hyman BT. Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy. The American Journal of Pathology. 168: 1598-607. PMID 16651626 DOI: 10.2353/Ajpath.2006.050840 |
0.436 |
|
| 2006 |
Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 4246-51. PMID 16537516 DOI: 10.1073/Pnas.0511256103 |
0.752 |
|
| 2006 |
Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, McKinstry WJ, Parker MW, Masters CL, Hyman BT, Cappai R, Willnow TE. Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. Biochemistry. 45: 2618-28. PMID 16489755 DOI: 10.1021/Bi052120V |
0.44 |
|
| 2006 |
Klucken J, Ingelsson M, Shin Y, Irizarry MC, Hedley-Whyte ET, Frosch M, Growdon J, McLean P, Hyman BT. Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. Acta Neuropathologica. 111: 101-8. PMID 16482476 DOI: 10.1007/S00401-005-0027-7 |
0.805 |
|
| 2006 |
Holtzer R, Irizarry MC, Sanders J, Hyman BT, Wegesin DJ, Riba A, Brandt J, Albert M, Stern Y. Relation of quantitative indexes of concurrent alpha-synuclein abnormalities to clinical outcome in autopsy-proven Alzheimer disease. Archives of Neurology. 63: 226-30. PMID 16476811 DOI: 10.1001/Archneur.63.2.226 |
0.429 |
|
| 2006 |
Spoelgen R, von Arnim CA, Thomas AV, Peltan ID, Koker M, Deng A, Irizarry MC, Andersen OM, Willnow TE, Hyman BT. Interaction of the cytosolic domains of sorLA/LR11 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 418-28. PMID 16407538 DOI: 10.1523/Jneurosci.3882-05.2006 |
0.394 |
|
| 2006 |
Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 365-71. PMID 16407531 DOI: 10.1523/Jneurosci.3854-05.2006 |
0.774 |
|
| 2006 |
Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochemical and Biophysical Research Communications. 340: 668-74. PMID 16376853 DOI: 10.1016/J.Bbrc.2005.12.063 |
0.301 |
|
| 2006 |
Ingelsson M, Blom E, Fukumoto H, Zetterberg H, Gårevik N, Blennow K, Hyman BT, Lannfelt L, Wahlund L, Irizarry MC. P2-160: Csf Aβ and tau levels in Alzheimer’s disease and mild cognitive impairment Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.998 |
0.401 |
|
| 2006 |
Callaghan PO, Yu H, Nilsson LNG, Ingelsson M, Hyman BT, Li J, Lindahl U, Lannfelt L, Zhang X. P1-387: Comparative analysis of heparan sulfate co-localization with Aβ40 and Aβ42 in different Aβ deposits of APP transgenic mice and Alzheimer’s disease patients Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.765 |
0.443 |
|
| 2006 |
Meyer-Luehmann M, Spires TL, Bacskai BJ, Hyman BT. P1-090: Observation of new senile plaque formation and associated neuritic abnormalities using multiphoton microscopy Alzheimer's & Dementia. 2: S121-S121. DOI: 10.1016/J.Jalz.2006.05.465 |
0.576 |
|
| 2006 |
Matsui T, Ingelsson M, Fukumoto H, Ramasamy K, Kowa H, Frosch MP, Irizarry MC, Hyman BT. P4-079: Coordinated expression of APP pathway mRNA and protein in AD Alzheimer's & Dementia. 2: S537-S537. DOI: 10.1016/J.Jalz.2006.05.1817 |
0.531 |
|
| 2006 |
Spires TL, Meyer-Luehmann M, Orne JD, Backskai BJ, Hyman BT. P3-434: In vivo multiphoton imaging reveals plaque-related deficits in structural plasticity, underlying dendritic spine loss in Tg2576 mice Alzheimer's & Dementia. 2: S503-S504. DOI: 10.1016/J.Jalz.2006.05.1705 |
0.303 |
|
| 2006 |
Thomas AV, Deng A, Herl L, Spoelgen R, Irizarry MC, Hyman BT. O2-03-03: Modulation of neuronal activity results in altered APP processing and spatial alignment of PS1 and APP Alzheimer's & Dementia. 2: S35-S35. DOI: 10.1016/J.Jalz.2006.05.122 |
0.307 |
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| 2006 |
Hyman BT, Spires T, Matsui T, Orne J, Pitstik R, Carlson GA, Ashe K. S2-02-05: Neuritic alterations and dysfunctions in Alzheimer's disease Alzheimer's & Dementia. 2: S26-S26. DOI: 10.1016/J.Jalz.2006.05.085 |
0.412 |
|
| 2005 |
Spires TL, Hyman BT. Transgenic models of Alzheimer's disease: learning from animals. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 423-37. PMID 16389306 DOI: 10.1602/Neurorx.2.3.423 |
0.495 |
|
| 2005 |
Cantuti-Castelvetri I, Klucken J, Ingelsson M, Ramasamy K, McLean PJ, Frosch MP, Hyman BT, Standaert DG. Alpha-synuclein and chaperones in dementia with Lewy bodies. Journal of Neuropathology and Experimental Neurology. 64: 1058-66. PMID 16319716 DOI: 10.1097/01.Jnen.0000190063.90440.69 |
0.767 |
|
| 2005 |
Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology. 65: 1402-8. PMID 16275827 DOI: 10.1212/01.Wnl.0000183063.99107.5C |
0.515 |
|
| 2005 |
Andersen OM, Reiche J, Schmidt V, Gotthardt M, Spoelgen R, Behlke J, von Arnim CA, Breiderhoff T, Jansen P, Wu X, Bales KR, Cappai R, Masters CL, Gliemann J, Mufson EJ, ... Hyman BT, et al. Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein. Proceedings of the National Academy of Sciences of the United States of America. 102: 13461-6. PMID 16174740 DOI: 10.1073/Pnas.0503689102 |
0.456 |
|
| 2005 |
Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. Journal of Neurochemistry. 95: 446-56. PMID 16086682 DOI: 10.1111/J.1471-4159.2005.03381.X |
0.407 |
|
| 2005 |
Spires TL, Meyer-Luehmann M, Stern EA, McLean PJ, Skoch J, Nguyen PT, Bacskai BJ, Hyman BT. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 7278-87. PMID 16079410 DOI: 10.1523/Jneurosci.1879-05.2005 |
0.82 |
|
| 2005 |
Nesterov EE, Skoch J, Hyman BT, Klunk WE, Bacskai BJ, Swager TM. In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angewandte Chemie (International Ed. in English). 44: 5452-6. PMID 16059955 DOI: 10.1002/Anie.200500845 |
0.574 |
|
| 2005 |
Xiang Z, Nesterov EE, Skoch J, Lin T, Hyman BT, Swager TM, Bacskai BJ, Reeves SA. Detection of myelination using a novel histological probe. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 53: 1511-6. PMID 16046669 DOI: 10.1369/Jhc.5A6704.2005 |
0.505 |
|
| 2005 |
Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 64: 588-94. PMID 16042310 DOI: 10.1097/01.Jnen.0000171644.00180.Fc |
0.788 |
|
| 2005 |
Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G. BACE is degraded via the lysosomal pathway. The Journal of Biological Chemistry. 280: 32499-504. PMID 16033761 DOI: 10.1074/Jbc.M506199200 |
0.366 |
|
| 2005 |
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, ... ... Hyman B, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science (New York, N.Y.). 309: 476-81. PMID 16020737 DOI: 10.1126/Science.1113694 |
0.423 |
|
| 2005 |
Skoch J, Hickey GA, Kajdasz ST, Hyman BT, Bacskai BJ. In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods in Molecular Biology (Clifton, N.J.). 299: 349-63. PMID 15980616 DOI: 10.1385/1-59259-874-9:349 |
0.624 |
|
| 2005 |
Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. The Journal of Biological Chemistry. 280: 27303-9. PMID 15917251 DOI: 10.1074/Jbc.M413969200 |
0.363 |
|
| 2005 |
Lee J, Fukumoto H, Orne J, Klucken J, Raju S, Vanderburg CR, Irizarry MC, Hyman BT, Ingelsson M. Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms. Experimental Neurology. 194: 91-6. PMID 15899246 DOI: 10.1016/J.Expneurol.2005.01.026 |
0.403 |
|
| 2005 |
Skoch J, Dunn A, Hyman BT, Bacskai BJ. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. Journal of Biomedical Optics. 10: 11007. PMID 15847573 DOI: 10.1117/1.1846075 |
0.612 |
|
| 2005 |
Shin Y, Klucken J, Patterson C, Hyman BT, McLean PJ. The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways. The Journal of Biological Chemistry. 280: 23727-34. PMID 15845543 DOI: 10.1074/Jbc.M503326200 |
0.724 |
|
| 2005 |
Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3009-17. PMID 15772361 DOI: 10.1523/Jneurosci.0364-05.2005 |
0.683 |
|
| 2005 |
von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, ... Hyman BT, et al. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. The Journal of Biological Chemistry. 280: 17777-85. PMID 15749709 DOI: 10.1074/Jbc.M414248200 |
0.587 |
|
| 2005 |
Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, et al. Family-based association between Alzheimer's disease and variants in UBQLN1. The New England Journal of Medicine. 352: 884-94. PMID 15745979 DOI: 10.1056/Nejmoa042765 |
0.395 |
|
| 2005 |
Moir RD, Tseitlin KA, Soscia S, Hyman BT, Irizarry MC, Tanzi RE. Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. The Journal of Biological Chemistry. 280: 17458-63. PMID 15728175 DOI: 10.1074/Jbc.M414176200 |
0.456 |
|
| 2005 |
Brendza RP, Bacskai BJ, Cirrito JR, Simmons KA, Skoch JM, Klunk WE, Mathis CA, Bales KR, Paul SM, Hyman BT, Holtzman DM. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. The Journal of Clinical Investigation. 115: 428-33. PMID 15668737 DOI: 10.1172/Jci23269 |
0.665 |
|
| 2005 |
Hyman BT, Augustinack JC, Ingelsson M. Transcriptional and conformational changes of the tau molecule in Alzheimer's disease. Biochimica Et Biophysica Acta. 1739: 150-7. PMID 15615634 DOI: 10.1016/J.Bbadis.2004.06.015 |
0.482 |
|
| 2004 |
Spires TL, Hyman BT. Neuronal structure is altered by amyloid plaques. Reviews in the Neurosciences. 15: 267-78. PMID 15526551 DOI: 10.1515/Revneuro.2004.15.4.267 |
0.508 |
|
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