Bradley T. Hyman, MD PhD - Related publications

Affiliations: 
Neurology Massachusetts General Hospital and Harvard University, Boston, MA, United States 
Area:
neuropathophysiologic and genetic factors that underlie dementia.
Website:
http://dms.hms.harvard.edu/neuroscience/fac/hyman.php
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 Robakis NK. What Do Recent Clinical Trials Teach Us About the Etiology of AD. Advances in Experimental Medicine and Biology. 1195: 167. PMID 32468473 DOI: 10.1007/978-3-030-32633-3_23   
2020 Chen M, Xia W. Proteomic Profiling of Plasma and Brain Tissue from Alzheimer's Disease Patients Reveals Candidate Network of Plasma Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 32474469 DOI: 10.3233/JAD-200110   
2020 Mamun AA, Uddin MS, Bin Bashar MF, Zaman S, Begum Y, Bulbul IJ, Islam MS, Sarwar MS, Mathew B, Amran MS, Md Ashraf G, Bin-Jumah MN, Mousa SA, Abdel-Daim MM. Molecular Insight into the Therapeutic Promise of Targeting for Alzheimer's Disease. Oxidative Medicine and Cellular Longevity. 2020: 5086250. PMID 32509144 DOI: 10.1155/2020/5086250   
2020 Ng PY, Chang IS, Koh RY, Chye SM. Recent advances in tau-directed immunotherapy against Alzheimer's disease: an overview of pre-clinical and clinical development. Metabolic Brain Disease. PMID 32632666 DOI: 10.1007/s11011-020-00591-6   
2020 Volicer L. Physiological and pathological functions of beta-amyloid in the brain and alzheimer's disease: A review. The Chinese Journal of Physiology. 63: 95-100. PMID 32594062 DOI: 10.4103/CJP.CJP_10_20   
2020 Liang Y, Raven F, Ward JF, Zhen S, Zhang S, Sun H, Miller SJ, Choi SH, Tanzi RE, Zhang C. Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo. Journal of Alzheimer's Disease : Jad. PMID 32597805 DOI: 10.3233/JAD-200128   
2020 Harris SS, Wolf F, De Strooper B, Busche MA. Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease. Neuron. PMID 32579881 DOI: 10.1016/j.neuron.2020.06.005   
2020 Jang JW, Kim Y, Kim S, Park SW, Kwon SO, Park YH, Lim JS, Youn YC, Hun Kim S, Kim S, . Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum. Neuroimage. Clinical. 27: 102282. PMID 32590333 DOI: 10.1016/j.nicl.2020.102282   
2020 Vasanthakumar A, Davis JW, Idler K, Waring JF, Asque E, Riley-Gillis B, Grosskurth S, Srivastava G, Kim S, Nho K, Nudelman KNH, Faber K, Sun Y, Foroud TM, Estrada K, ... , et al. Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease. Clinical Epigenetics. 12: 84. PMID 32539856 DOI: 10.1186/s13148-020-00864-y   
2020 Zhou R, Hu W, Dai CL, Gong CX, Iqbal K, Zhu D, Liu F. Expression of Microtubule Associated Protein Tau in Mouse Pancreatic Islets Is Restricted to Autonomic Nerve Fibers. Journal of Alzheimer's Disease : Jad. PMID 32417779 DOI: 10.3233/JAD-200101   
2020 Eke CS, Jammeh E, Li X, Carroll C, Pearson S, Ifeachor E. Early Detection of Alzheimer's Disease with Blood Plasma Proteins using Support Vector Machines. Ieee Journal of Biomedical and Health Informatics. PMID 32340968 DOI: 10.1109/JBHI.2020.2984355   
2020 Cairns DM, Rouleau N, Parker RN, Walsh KG, Gehrke L, Kaplan DL. A 3D human brain-like tissue model of herpes-induced Alzheimer's disease. Science Advances. 6: eaay8828. PMID 32494701 DOI: 10.1126/sciadv.aay8828   
2020 Singh M, Singh SP, Dubey PK, Rachana R, Mani S, Yadav D, Agarwal M, Agarwal S, Agarwal V, Kaur H. Advent of Proteomic Tools For Diagnostic Biomarker Analysis in Alzheimer's Disease. Current Protein & Peptide Science. PMID 32538723 DOI: 10.2174/1389203721666200615173213   
2020 Cheng X, Song C, Du Y, Gaur U, Yang M. Pharmacological Treatment of Alzheimer's Disease: Insights from . International Journal of Molecular Sciences. 21. PMID 32610577 DOI: 10.3390/ijms21134621   
2020 Uddin MS, Kabir MT, Al Mamun A, Behl T, Mansouri RA, Aloqbi AA, Perveen A, Hafeez A, Ashraf GM. Exploring Potential of Alkaloidal Phytochemicals Targeting Neuroinflammatory Signaling of Alzheimer's Disease. Current Pharmaceutical Design. PMID 32473620 DOI: 10.2174/1381612826666200531151004   
2020 Puzzo D, Argyrousi EK, Staniszewski A, Zhang H, Calcagno E, Zuccarello E, Acquarone E, Fà M, Li Puma DD, Grassi C, D'Adamio L, Kanaan NM, Fraser PE, Arancio O. Tau is not necessary for amyloid-beta-induced synaptic and memory impairments. The Journal of Clinical Investigation. PMID 32544084 DOI: 10.1172/JCI137040   
2020 Hammond TC, Xing X, Wang C, Ma D, Nho K, Crane PK, Elahi F, Ziegler DA, Liang G, Cheng Q, Yanckello LM, Jacobs N, Lin AL. β-amyloid and tau drive early Alzheimer's disease decline while glucose hypometabolism drives late decline. Communications Biology. 3: 352. PMID 32632135 DOI: 10.1038/s42003-020-1079-x   
2020 Gericke C, Mallone A, Engelhardt B, Nitsch RM, Ferretti MT. Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation. Frontiers in Immunology. 11: 1029. PMID 32582162 DOI: 10.3389/fimmu.2020.01029   
2020 Li D, Zhang J, Li X, Chen Y, Yu F, Liu Q. Insights into lncRNAs in Alzheimer's Disease Mechanisms. Rna Biology. PMID 32605500 DOI: 10.1080/15476286.2020.1788848   
2020 Khalaf NEA, El Banna FM, Youssef MY, Mosaad YM, Daba MY, Ashour RH. Clopidogrel combats neuroinflammation and enhances learning behavior and memory in a rat model of Alzheimer's disease. Pharmacology, Biochemistry, and Behavior. 172956. PMID 32474163 DOI: 10.1016/j.pbb.2020.172956   
2020 Dujardin S, Commins C, Lathuiliere A, Beerepoot P, Fernandes AR, Kamath TV, De Los Santos MB, Klickstein N, Corjuc DL, Corjuc BT, Dooley PM, Viode A, Oakley DH, Moore BD, Mullin K, et al. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nature Medicine. PMID 32572268 DOI: 10.1038/s41591-020-0938-9   
2020 Liu M, Qian T, Zhou W, Tao X, Sang S, Zhao L. Beneficial effects of low-dose lithium on cognitive ability and pathological alteration of Alzheimer's disease transgenic mice model. Neuroreport. PMID 32639272 DOI: 10.1097/WNR.0000000000001499   
2020 Cable J, Holtzman DM, Hyman BT, Tansey MG, Colonna M, Kellis M, Brinton RD, Albert M, Wellington CL, Sisodia SS, Tanzi RE. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Annals of the New York Academy of Sciences. PMID 32472577 DOI: 10.1111/nyas.14371   
2020 Pérez-González M, Mendioroz M, Badesso S, Sucunza D, Roldan M, Espelosín M, Ursua S, Luján R, Cuadrado-Tejedor M, Garcia-Osta A. PLA2G4E, a candidate gene for resilience in Alzheimer´s disease and a new target for dementia treatment. Progress in Neurobiology. 101818. PMID 32380223 DOI: 10.1016/j.pneurobio.2020.101818   
2020 Dahal E, Ghammraoui B, Badano A. Feasibility of a label-free X-ray method to estimate brain amyloid load in small animals. Journal of Neuroscience Methods. 343: 108822. PMID 32574641 DOI: 10.1016/j.jneumeth.2020.108822   
2020 Sinsky J, Majerova P, Kovac A, Kotlyar M, Jurisica I, Hanes J. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Journal of Proteome Research. 19: 2429-2442. PMID 32357304 DOI: 10.1021/acs.jproteome.0c00137   
2020 Bhute S, Sarmah D, Datta A, Rane P, Shard A, Goswami A, Borah A, Kalia K, Dave KR, Bhattacharya P. Molecular Pathogenesis and Interventional Strategies for Alzheimer's Disease: Promises and Pitfalls. Acs Pharmacology & Translational Science. 3: 472-488. PMID 32566913 DOI: 10.1021/acsptsci.9b00104   
2020 Uddin MS, Kabir MT, Mamun AA, Barreto GE, Rashid M, Perveen A, Ashraf GM. Pharmacological approaches to mitigate neuroinflammation in Alzheimer's disease. International Immunopharmacology. 84: 106479. PMID 32353686 DOI: 10.1016/j.intimp.2020.106479   
2020 Venkataraman L, He P, Schulz P, Sierks MR. Isolation and characterization of antibody fragment selective for human Alzheimer's disease brain-derived tau variants. Neurobiology of Aging. 94: 7-14. PMID 32497877 DOI: 10.1016/j.neurobiolaging.2020.04.014   
2020 Rafii MS. Alzheimer's Disease in Down Syndrome: Progress in the Design and Conduct of Drug Prevention Trials. Cns Drugs. PMID 32506291 DOI: 10.1007/s40263-020-00740-6   
2020 Yuan C, Aierken A, Xie Z, Li N, Zhao J, Qing H. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiology of Aging. 92: 82-91. PMID 32408056 DOI: 10.1016/j.neurobiolaging.2020.03.024   
2020 Nanjundaiah S, Chidambaram H, Chandrashekar M, Chinnathambi S. Role of Microglia in Regulating Cholesterol and Tau Pathology in Alzheimer's Disease. Cellular and Molecular Neurobiology. PMID 32468440 DOI: 10.1007/s10571-020-00883-6   
2020 Plascencia-Villa G, Perry G. Preventive and therapeutic strategies in Alzheimer's disease: focus on oxidative stress, redox metals and ferroptosis. Antioxidants & Redox Signaling. PMID 32486897 DOI: 10.1089/ars.2020.8134   
2020 Yang Y, Zhang Z. Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer's Disease. Frontiers in Aging Neuroscience. 12: 110. PMID 32477095 DOI: 10.3389/fnagi.2020.00110   
2020 Paraskevaidi M, Allsop D, Karim S, Martin FL, Crean S. Diagnostic Biomarkers for Alzheimer's Disease Using Non-Invasive Specimens. Journal of Clinical Medicine. 9. PMID 32492907 DOI: 10.3390/jcm9061673   
2020 Konijnenberg E, Tijms BM, Gobom J, Dobricic V, Bos I, Vos S, Tsolaki M, Verhey F, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Frölich L, Lovestone S, Streffer J, et al. APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer's disease. Alzheimer's Research & Therapy. 12: 65. PMID 32460813 DOI: 10.1186/s13195-020-00628-z   
2020 Gorantla NV, Balaraman E, Chinnathambi S. Cobalt-based metal complexes prevent Repeat Tau aggregation and nontoxic to neuronal cells. International Journal of Biological Macromolecules. 152: 171-179. PMID 32105696 DOI: 10.1016/j.ijbiomac.2020.02.278   
2020 Yang J, Wise L, Fukuchi KI. TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease. Frontiers in Immunology. 11: 724. PMID 32391019 DOI: 10.3389/fimmu.2020.00724   
2020 Barthet G, Mulle C. Presynaptic failure in Alzheimer's disease. Progress in Neurobiology. 101801. PMID 32428558 DOI: 10.1016/j.pneurobio.2020.101801   
2020 Park SY, Kang JY, Lee T, Nam D, Jeon CJ, Kim JB. Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model. Cells. 9. PMID 32455709 DOI: 10.3390/cells9051275   
2020 Schnöder L, Gasparoni G, Nordström K, Schottek A, Tomic I, Christmann A, Schäfer KH, Menger MD, Walter J, Fassbender K, Liu Y. Neuronal deficiency of p38α-MAPK ameliorates symptoms and pathology of APP or Tau-transgenic Alzheimer's mouse models. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32475008 DOI: 10.1096/fj.201902731RR   
2020 Hammes J, Bischof GN, Bohn KP, Onur O, Schneider A, Fliessbach K, Hoenig MC, Jessen F, Neumaier B, Drzezga AE, van Eimeren T. One stop shop: Flortaucipir PET differentiates amyloid positive and negative forms of neurodegenerative diseases. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 32620704 DOI: 10.2967/jnumed.120.244061   
2020 Wang L, Zhou Y, Chen D, Lee TH. Peptidyl-Prolyl Isomerase Pin1 and Alzheimer's Disease. Frontiers in Cell and Developmental Biology. 8: 355. PMID 32500074 DOI: 10.3389/fcell.2020.00355   
2020 Kloske CM, Wilcock DM. The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer's Disease. Frontiers in Immunology. 11: 754. PMID 32425941 DOI: 10.3389/fimmu.2020.00754   
2020 Choi JW, Ju YH, Choi Y, Hyeon SJ, Gadhe CG, Park JH, Kim MS, Baek S, Kim Y, Park KD, Pae AN, Ryu H, Lee CJ, Cho BR. PyrPeg, a Blood-Brain Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, not Tau Aggregates. Acs Chemical Neuroscience. PMID 32421307 DOI: 10.1021/acschemneuro.0c00211   
2020 Golub JS, Sharma RK, Rippon BQ, Brickman AM, Luchsinger JA. The Association Between Early Age-Related Hearing Loss and Brain β-Amyloid. The Laryngoscope. PMID 32644260 DOI: 10.1002/lary.28859   
2020 Stefanescu R, Stanciu GD, Luca A, Paduraru L, Tamba BI. Secondary Metabolites from Plants Possessing Inhibitory Properties against Beta-Amyloid Aggregation as Revealed by Thioflavin-T Assay and Correlations with Investigations on Transgenic Mouse Models of Alzheimer's Disease. Biomolecules. 10. PMID 32517180 DOI: 10.3390/biom10060870   
2020 Shah H, Patel A, Parikh V, Nagani A, Bhimani B, Shah U, Bambharoliya T. The β-secretase enzyme BACE1: A biochemical enigma for Alzheimer's disease. Cns & Neurological Disorders Drug Targets. PMID 32452328 DOI: 10.2174/1871527319666200526144141   
2020 Kim JW, Byun MS, Yi D, Lee JH, Jeon SY, Ko K, Jung G, Lee HN, Lee JY, Sohn CH, Lee YS, Shin SA, Kim YK, Lee DY, . Serum Uric Acid, Alzheimer-Related Brain Changes, and Cognitive Impairment. Frontiers in Aging Neuroscience. 12: 160. PMID 32581770 DOI: 10.3389/fnagi.2020.00160   
2020 Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, et al. Tau PET imaging with F-PI-2620 in aging and neurodegenerative diseases. European Journal of Nuclear Medicine and Molecular Imaging. PMID 32572562 DOI: 10.1007/s00259-020-04923-7