Ken-ichi Arai - Publications

Affiliations: 
Institute of Medical Science University of Tokyo, Bunkyō-ku, Tōkyō-to, Japan 

143 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Arai K, Nakagawa Y, Iwata T, Horiguchi H, Murata K. Relationships between QT interval and heart rate variability at rest and the covariates in healthy young adults. Autonomic Neuroscience : Basic & Clinical. 173: 53-7. PMID 23206810 DOI: 10.1016/j.autneu.2012.11.006  0.377
2009 Toma-Hirano M, Namiki S, Shibata Y, Ishida K, Arase H, Miyatake S, Arai K, Kamogawa-Schifter Y. Ly49Q ligand expressed by activated B cells induces plasmacytoid DC maturation. European Journal of Immunology. 39: 1344-52. PMID 19350550 DOI: 10.1002/Eji.200838363  0.322
2008 Chen J, Namiki S, Toma-Hirano M, Miyatake S, Ishida K, Shibata Y, Arai N, Arai K, Kamogawa-Schifter Y. The role of CD11b in phagocytosis and dendritic cell development. Immunology Letters. 120: 42-8. PMID 18674565 DOI: 10.1016/J.Imlet.2008.06.010  0.312
2008 Cho M, Ishida K, Chen J, Ohkawa J, Chen W, Namiki S, Kotaki A, Arai N, Arai K, Kamogawa-Schifter Y. SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production. International Immunology. 20: 155-64. PMID 18048391 DOI: 10.1093/Intimm/Dxm127  0.334
2006 Masai H, Taniyama C, Ogino K, Matsui E, Kakusho N, Matsumoto S, Kim JM, Ishii A, Tanaka T, Kobayashi T, Tamai K, Ohtani K, Arai K. Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin. The Journal of Biological Chemistry. 281: 39249-61. PMID 17046832 DOI: 10.1074/Jbc.M608935200  0.355
2006 Ogino K, Hirota K, Matsumoto S, Takeda T, Ohta K, Arai K, Masai H. Hsk1 kinase is required for induction of meiotic dsDNA breaks without involving checkpoint kinases in fission yeast. Proceedings of the National Academy of Sciences of the United States of America. 103: 8131-6. PMID 16698922 DOI: 10.1073/Pnas.0602498103  0.33
2006 Muto A, Arai K, Watanabe S. Rab11-FIP4 is predominantly expressed in neural tissues and involved in proliferation as well as in differentiation during zebrafish retinal development. Developmental Biology. 292: 90-102. PMID 16457799 DOI: 10.1016/J.Ydbio.2005.12.050  0.322
2005 Saito R, Tabata Y, Muto A, Arai K, Watanabe S. Melk-like kinase plays a role in hematopoiesis in the zebra fish. Molecular and Cellular Biology. 25: 6682-93. PMID 16024803 DOI: 10.1128/Mcb.25.15.6682-6693.2005  0.32
2005 Yamashita N, Kim JM, Koiwai O, Arai K, Masai H. Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 10: 551-63. PMID 15938714 DOI: 10.1111/J.1365-2443.2005.00857.X  0.371
2005 Yoshizawa-Sugata N, Ishii A, Taniyama C, Matsui E, Arai K, Masai H. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. The Journal of Biological Chemistry. 280: 13062-70. PMID 15668232 DOI: 10.1074/Jbc.M411653200  0.353
2005 Fujii-Yamamoto H, Kim JM, Arai K, Masai H. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. The Journal of Biological Chemistry. 280: 12976-87. PMID 15659392 DOI: 10.1074/Jbc.M412224200  0.337
2005 Kamogawa-Schifter Y, Ohkawa J, Namiki S, Arai N, Arai K, Liu Y. Ly49Q defines 2 pDC subsets in mice. Blood. 105: 2787-92. PMID 15598811 DOI: 10.1182/Blood-2004-09-3388  0.34
2004 Sato N, Nakayama M, Arai K. Fluctuation of chromatin unfolding associated with variation in the level of gene expression. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 9: 619-30. PMID 15265005 DOI: 10.1111/J.1356-9597.2004.00751.X  0.317
2004 Tabata Y, Ouchi Y, Kamiya H, Manabe T, Arai K, Watanabe S. Specification of the retinal fate of mouse embryonic stem cells by ectopic expression of Rx/rax, a homeobox gene. Molecular and Cellular Biology. 24: 4513-21. PMID 15121868 DOI: 10.1128/Mcb.24.10.4513-4521.2004  0.304
2003 Furukohri A, Sato N, Masai H, Arai K, Sugino A, Waga S. Identification and characterization of a Xenopus homolog of Dbf4, a regulatory subunit of the Cdc7 protein kinase required for the initiation of DNA replication. Journal of Biochemistry. 134: 447-57. PMID 14561731 DOI: 10.1093/Jb/Mvg163  0.346
2003 Kim JM, Takemoto N, Arai K, Masai H. Hypomorphic mutation in an essential cell-cycle kinase causes growth retardation and impaired spermatogenesis. The Embo Journal. 22: 5260-72. PMID 14517263 DOI: 10.1093/Emboj/Cdg497  0.315
2003 Mizukoshi T, Tanaka T, Arai K, Kohda D, Masai H. A critical role of the 3' terminus of nascent DNA chains in recognition of stalled replication forks. The Journal of Biological Chemistry. 278: 42234-9. PMID 12917421 DOI: 10.1074/Jbc.C300285200  0.304
2003 Sato N, Sato M, Nakayama M, Saitoh R, Arai K, Masai H. Cell cycle regulation of chromatin binding and nuclear localization of human Cdc7-ASK kinase complex. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 8: 451-63. PMID 12694534 DOI: 10.1046/J.1365-2443.2003.00647.X  0.39
2003 Chen J, Amasaki Y, Kamogawa Y, Nagoya M, Arai N, Arai K, Miyatake S. Role of NFATx (NFAT4/NFATc3) in expression of immunoregulatory genes in murine peripheral CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 3109-17. PMID 12626567 DOI: 10.4049/Jimmunol.170.6.3109  0.356
2003 Tanaka T, Taniyama C, Arai K, Masai H. ATPase/helicase motif mutants of Escherichia coli PriA protein essential for recombination-dependent DNA replication. Genes to Cells : Devoted to Molecular & Cellular Mechanisms. 8: 251-61. PMID 12622722 DOI: 10.1046/J.1365-2443.2003.00630.X  0.311
2003 Akagawa E, Muto A, Arai K, Watanabe S. Analysis of the 5' promoters for human IL-3 and GM-CSF receptor alpha genes. Biochemical and Biophysical Research Communications. 300: 600-8. PMID 12504125 DOI: 10.1016/S0006-291X(02)02890-5  0.394
2002 Yuyama N, Davies DE, Akaiwa M, Matsui K, Hamasaki Y, Suminami Y, Yoshida NL, Maeda M, Pandit A, Lordan JL, Kamogawa Y, Arima K, Nagumo F, Sugimachi M, Berger A, ... ... Arai KI, et al. Analysis of novel disease-related genes in bronchial asthma Cytokine. 19: 287-296. PMID 12421571 DOI: 10.1006/Cyto.2002.1972  0.306
2002 Takemoto N, Arai K, Miyatake S. Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 development. Journal of Immunology (Baltimore, Md. : 1950). 169: 4103-7. PMID 12370337 DOI: 10.4049/Jimmunol.169.8.4103  0.319
2002 Tanaka T, Mizukoshi T, Taniyama C, Kohda D, Arai K, Masai H. DNA binding of PriA protein requires cooperation of the N-terminal D-loop/arrested-fork binding and C-terminal helicase domains. The Journal of Biological Chemistry. 277: 38062-71. PMID 12151393 DOI: 10.1074/Jbc.M204397200  0.307
2002 Yasuda Y, Kaneko A, Nishijima I, Miyatake S, Arai K. Interleukin-7 inhibits pre-T-cell differentiation induced by the pre-T-cell receptor signal and the effect is mimicked by hGM-CSF in hGM-CSF receptor transgenic mice. Immunology. 106: 212-21. PMID 12047750 DOI: 10.1046/J.1365-2567.2002.01402.X  0.384
2002 Amasaki Y, Adachi S, Ishida Y, Iwata M, Arai N, Arai K, Miyatake S. A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells. The Journal of Biological Chemistry. 277: 25640-8. PMID 11997392 DOI: 10.1074/Jbc.M201860200  0.326
2002 Kim JM, Nakao K, Nakamura K, Saito I, Katsuki M, Arai K, Masai H. Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death. The Embo Journal. 21: 2168-79. PMID 11980714 DOI: 10.1093/Emboj/21.9.2168  0.336
2002 Zeng R, Aoki Y, Yoshida M, Arai K, Watanabe S. Stat5B shuttles between cytoplasm and nucleus in a cytokine-dependent and -independent manner. Journal of Immunology (Baltimore, Md. : 1950). 168: 4567-75. PMID 11971004 DOI: 10.4049/Jimmunol.168.9.4567  0.362
2002 Masai H, Arai K. Cdc7 kinase complex: a key regulator in the initiation of DNA replication. Journal of Cellular Physiology. 190: 287-96. PMID 11857444 DOI: 10.1002/Jcp.10070  0.327
2001 Hisakawa H, Sugiyama D, Nishijima I, Xu M, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 98: 3618-3625. PMID 11739165 DOI: 10.1182/Blood.V98.13.3618  0.357
2001 Ishimi Y, Komamura-Kohno Y, Arai K, Masai H. Biochemical activities associated with mouse Mcm2 protein. The Journal of Biological Chemistry. 276: 42744-52. PMID 11568184 DOI: 10.1074/Jbc.M106861200  0.358
2001 Takeda M, Dohmae N, Takio K, Arai K, Watanabe S. Cell cycle-dependent interaction of Mad2 with conserved Box1/2 region of human granulocyte-macrophage colony-stimulating factor receptor common betac. The Journal of Biological Chemistry. 276: 41803-9. PMID 11551900 DOI: 10.1074/Jbc.M101488200  0.371
2001 Uchiyama M, Arai K, Masai H. Sna41goa1, a novel mutation causing G1/S arrest in fission yeast, is defective in a CDC45 homolog and interacts genetically with polalpha. Molecular Genetics and Genomics : Mgg. 265: 1039-49. PMID 11523776 DOI: 10.1007/S004380100499  0.313
2001 Liu J, Arai K, Arai N. Inhibition of NFATx activation by an oligopeptide: disrupting the interaction of NFATx with calcineurin. Journal of Immunology (Baltimore, Md. : 1950). 167: 2677-87. PMID 11509611 DOI: 10.4049/Jimmunol.167.5.2677  0.358
2001 Ogino K, Takeda T, Matsui E, Iiyama H, Taniyama C, Arai K, Masai H. Bipartite binding of a kinase activator activates Cdc7-related kinase essential for S phase. The Journal of Biological Chemistry. 276: 31376-87. PMID 11402029 DOI: 10.1074/Jbc.M102197200  0.36
2001 Takeda T, Ogino K, Tatebayashi K, Ikeda H, Arai K, Masai H. Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast. Molecular Biology of the Cell. 12: 1257-1274. PMID 11359920 DOI: 10.1091/Mbc.12.5.1257  0.336
2001 Uchiyama M, Griffiths D, Arai K, Masai H. Essential role of Sna41/Cdc45 in loading of DNA polymerase alpha onto minichromosome maintenance proteins in fission yeast. The Journal of Biological Chemistry. 276: 26189-96. PMID 11344166 DOI: 10.1074/Jbc.M100007200  0.323
2001 Watanabe S, Zeng R, Aoki Y, Itoh T, Arai K. Initiation of polyoma virus origin-dependent DNA replication through STAT5 activation by human granulocyte-macrophage colony-stimulating factor. Blood. 97: 1266-1273. PMID 11222369 DOI: 10.1182/Blood.V97.5.1266  0.388
2001 Woods JM, Katschke KJ, Volin MV, Ruth JH, Woodruff DC, Amin MA, Connors MA, Kurata H, Arai K, Haines GK, Kumar P, Koch AE. IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis. Journal of Immunology (Baltimore, Md. : 1950). 166: 1214-22. PMID 11145704 DOI: 10.4049/Jimmunol.166.2.1214  0.31
2001 Miyatake S, Arai N, Arai K. Chromatin remodeling and T helper subset differentiation. Iubmb Life. 49: 473-8. PMID 11032239 DOI: 10.1080/15216540050166990  0.351
2000 Sakurai Y, Arai K, Watanabe S. In vitro analysis of STAT5 activation by granulocyte-macrophage colony-stimulating factor. Genes to Cells. 5: 937-947. PMID 11122381 DOI: 10.1046/J.1365-2443.2000.00379.X  0.379
2000 Takemoto N, Kamogawa Y, Lee HJ, Kurata H, Arai K, O’Garra A, Arai N, Miyatake S. Cutting Edge: Chromatin Remodeling at the IL-4/IL-13 Intergenic Regulatory Region for Th2-Specific Cytokine Gene Cluster Journal of Immunology. 165: 6687-6691. PMID 11120785 DOI: 10.4049/Jimmunol.165.12.6687  0.327
2000 Masai H, Arai K. Dbf4 motifs: conserved motifs in activation subunits for Cdc7 kinases essential for S-phase. Biochemical and Biophysical Research Communications. 275: 228-232. PMID 10944469 DOI: 10.1006/Bbrc.2000.3281  0.314
2000 Masai H, Arai K. Regulation of DNA Replication During the Cell Cycle: Roles of Cdc7 Kinase and Coupling of Replication, Recombination, and Repair in Response to Replication Fork Arrest Iubmb Life. 49: 353-364. PMID 10902566 DOI: 10.1080/152165400410191  0.311
2000 Liu R, Arai K, Watanabe S. Analysis of antiapoptosis activity of human GM-CSF receptor. The Journal of Allergy and Clinical Immunology. 106. PMID 10887329 DOI: 10.1067/Mai.2000.106772  0.366
2000 Amasaki Y, Miyatake S, Arai N, Arai K. Regulation of nuclear factor of activated T-cell family transcription factors during T-cell development in the thymus. The Journal of Allergy and Clinical Immunology. 106: S1-9. PMID 10887328 DOI: 10.1067/Mai.2000.106061  0.321
2000 Pan S, Tsuruta R, Masuda ES, Imamura R, Bazan F, Arai K, Arai N, Miyatake S. NFATz: a novel rel similarity domain containing protein. Biochemical and Biophysical Research Communications. 272: 765-76. PMID 10860829 DOI: 10.1006/Bbrc.2000.2831  0.361
2000 Masai H, Matsui E, You Z, Ishimi Y, Tamai K, Arai K. Human Cdc7-related kinase complex. In vitro phosphorylation of MCM by concerted actions of Cdks and Cdc7 and that of a criticial threonine residue of Cdc7 bY Cdks. The Journal of Biological Chemistry. 275: 29042-52. PMID 10846177 DOI: 10.1074/Jbc.M002713200  0.325
2000 Liu R, Liu CB, Mohi MG, Arai K, Watanabe S. Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF. Oncogene. 19: 571-9. PMID 10698527 DOI: 10.1038/Sj.Onc.1203364  0.342
2000 Dahl ME, Arai K, Watanabe S. Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis. Genes to Cells. 5: 143-153. PMID 10672044 DOI: 10.1046/J.1365-2443.2000.00312.X  0.347
2000 Harada Y, Miyatake S, Arai K, Watanabe S. Cyclic AMP inhibits the activity of c-Jun N-terminal kinase (JNKp46) but not JNKp55 and ERK2 in human helper T lymphocytes. Biochemical and Biophysical Research Communications. 266: 129-34. PMID 10581177 DOI: 10.1006/Bbrc.1999.1783  0.333
1999 Masai H, Sato N, Takeda T, Arai K. CDC7 kinase complex as a molecular switch for DNA replication. Frontiers in Bioscience : a Journal and Virtual Library. 4: D834-40. PMID 10577390 DOI: 10.2741/Masai  0.361
1999 Masai H, Deneke J, Furui Y, Tanaka T, Arai K. Escherichia coli and Bacillus subtilis PriA proteins essential for recombination-dependent DNA replication: Involvement of ATPase/helicase activity of PriA for inducible stable DNA replication Biochimie. 81: 847-857. PMID 10572298 DOI: 10.1016/S0300-9084(99)00211-4  0.33
1999 Liu R, Itoh T, Arai K, Watanabe S. Two Distinct Signaling Pathways Downstream of Janus Kinase 2 Play Redundant Roles for Antiapoptotic Activity of Granulocyte-Macrophage Colony-stimulating Factor Molecular Biology of the Cell. 10: 3959-3970. PMID 10564283 DOI: 10.1091/Mbc.10.11.3959  0.367
1999 Takeda T, Ogino K, Matsui E, Cho MK, Kumagai H, Miyake T, Arai K, Masai H. A fission yeast gene, him1(+)/dfp1(+), encoding a regulatory subunit for Hsk1 kinase, plays essential roles in S-phase initiation as well as in S-phase checkpoint control and recovery from DNA damage. Molecular and Cellular Biology. 19: 5535-47. PMID 10409743 DOI: 10.1128/Mcb.19.8.5535  0.369
1999 Kumagai H, Sato N, Yamada M, Mahony D, Seghezzi W, Lees E, Arai K, Masai H. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. Molecular and Cellular Biology. 19: 5083-95. PMID 10373557 DOI: 10.1128/Mcb.19.7.5083  0.369
1999 Itoh T, Liu R, Arai K, Watanabe S. Differential influence of tyrosine residues of the common receptor β subunit on multiple signals induced by human GM-CSF The Journal of Allergy and Clinical Immunology. 103. PMID 10329850 DOI: 10.1016/S0091-6749(99)70163-6  0.359
1999 Liu C, Itoh T, Arai K, Watanabe S. Constitutive activation of JAK2 confers murine interleukin-3-independent survival and proliferation of BA/F3 cells. Journal of Biological Chemistry. 274: 6342-6349. PMID 10037724 DOI: 10.1074/Jbc.274.10.6342  0.373
1998 Mohi MG, Arai K, Watanabe S. Activation and Functional Analysis of Janus Kinase 2 in BA/F3 Cells Using the Coumermycin/Gyrase B System Molecular Biology of the Cell. 9: 3299-3308. PMID 9843570 DOI: 10.1091/Mbc.9.12.3299  0.388
1998 Kim JM, Sato N, Yamada M, Arai K, Masai H. Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for s. cerevisiae Cdc7-related kinase. The Journal of Biological Chemistry. 273: 23248-57. PMID 9722556 DOI: 10.1074/Jbc.273.36.23248  0.372
1998 Itoh T, Liu R, Yokota T, Arai K, Watanabe S. Definition of the Role of Tyrosine Residues of the Common β Subunit Regulating Multiple Signaling Pathways of Granulocyte-Macrophage Colony-Stimulating Factor Receptor Molecular and Cellular Biology. 18: 742-752. PMID 9447970 DOI: 10.1128/Mcb.18.2.742  0.396
1998 Yasuda Y, Nishijima I, Watanabe S, Arai K. Thymocyte proliferation and differentiation in human granulocyte-macrophage colony-stimulating factor receptor transgenic mice. The Journal of Allergy and Clinical Immunology. 100: S87-96. PMID 9440552 DOI: 10.1016/S0091-6749(97)70012-5  0.312
1998 Nishijima I, Watanabe S, Nakahata T, Arai K. Human granulocyte-macrophage colony-stimulating factor (hGM-CSF)-dependent in vitro and in vivo proliferation and differentiation of all hematopoietic progenitor cells in hGM-CSF receptor transgenic mice. The Journal of Allergy and Clinical Immunology. 100: S79-86. PMID 9440551 DOI: 10.1016/S0091-6749(97)70011-3  0.347
1997 Sato N, Arai K, Masai H. Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7. The Embo Journal. 16: 4340-51. PMID 9250678 DOI: 10.1093/Emboj/16.14.4340  0.386
1997 Ohtoshi A, Miyake T, Arai K, Masai H. Analyses of Saccharomyces cerevisiae Cdc7 kinase point mutants: dominant-negative inhibition of DNA replication on overexpression of kinase-negative Cdc7 proteins. Molecular & General Genetics : Mgg. 254: 562-70. PMID 9197416 DOI: 10.1007/S004380050452  0.333
1997 Liu R, Itoh T, Arai K, Watanabe S. Activation of c-Jun N-terminal kinase by human granulocyte macrophage-colony stimulating factor in BA/F3 cells. Biochemical and Biophysical Research Communications. 234: 611-615. PMID 9175761 DOI: 10.1006/Bbrc.1997.6643  0.371
1997 Harada Y, Watanabe S, Yssel H, Arai K. Factors affecting the cytokine production of human T cells stimulated by different modes of activation. The Journal of Allergy and Clinical Immunology. 98: S161-73. PMID 8977524 DOI: 10.1016/S0091-6749(96)70063-5  0.369
1996 Masai H, Arai K. DnaA- and PriA-DEPENDENT PRIMOSOMES: TWO DISTINCT REPLICATION COMPLEXES FOR REPLICATION OF Escherichia coli CHROMOSOME Frontiers in Bioscience. 1. PMID 9159210 DOI: 10.2741/A115  0.308
1996 Masai H, Arai K. Mechanisms of primer RNA synthesis and D-loop/R-loop-dependent DNA replication in Escherichia coli Biochimie. 78: 1109-1117. PMID 9150892 DOI: 10.1016/S0300-9084(97)86737-5  0.303
1996 Ohtoshi A, Arai K, Masai H. Genetic interactions between CDC7 and CDC28: growth inhibition of cdc28-1N by Cdc7 point mutants. Genes to Cells. 1: 895-904. PMID 9077449 DOI: 10.1046/J.1365-2443.1996.D01-212.X  0.346
1996 Watanabe S, Itoh T, Arai K. Roles of JAK kinases in human GM-CSF receptor signal transduction The Journal of Allergy and Clinical Immunology. 98. PMID 8977526 DOI: 10.1016/S0091-6749(96)70065-9  0.397
1996 Nakagawa Y, Kaneko T, Ogura T, Suzuki T, Torii M, Kaibuchi K, Arai K, Nakamura S, Nakafuku M. Roles of cell-autonomous mechanisms for differential expression of region-specific transcription factors in neuroepithelial cells. Development (Cambridge, England). 122: 2449-64. PMID 8756290  0.675
1996 Naito Y, Endo H, Arai K, Coffman RL, Arai N. Signal transduction in Th clones: target of differential modulation by PGE2 may reside downstream of the PKC-dependent pathway. Cytokine. 8: 346-56. PMID 8726662 DOI: 10.1006/Cyto.1996.0048  0.335
1996 Watanabe S, Itoh T, Arai K. JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells Journal of Biological Chemistry. 271: 12681-12686. PMID 8647882 DOI: 10.1074/Jbc.271.21.12681  0.404
1996 Itoh T, Muto A, Watanabe S, Miyajima A, Yokota T, Arai K. Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling. The Journal of Biological Chemistry. 271: 7587-92. PMID 8631792 DOI: 10.1074/Jbc.271.13.7587  0.363
1996 Tsuruta L, Lee HJ, Masuda ES, Yokota T, Arai N, Arai K. Regulation of expression of the IL-2 and IL-5 genes and the role of proteins related to nuclear factor of activated T cells. The Journal of Allergy and Clinical Immunology. 96: 1126-35. PMID 8543769 DOI: 10.1016/S0091-6749(95)70197-4  0.384
1996 Kurata H, Arai T, Yokota T, Arai K. Differential expression of granulocyte-macrophage colony-stimulating factor and IL-3 receptor subunits on human CD34+ cells and leukemic cell lines. The Journal of Allergy and Clinical Immunology. 96: 1083-99. PMID 8543766 DOI: 10.1016/S0091-6749(95)70194-X  0.37
1995 Kosugi H, Nakagawa Y, Arai K, Yokota T. Gene structures of the alpha subunits of human IL-3 and granulocyte-macrophage colony-stimulating factor receptors: comparison with the cytokine receptor superfamily. The Journal of Allergy and Clinical Immunology. 96: 1115-25. PMID 8543768 DOI: 10.1016/S0091-6749(95)70196-6  0.495
1995 Kosugi H, Nakagawa Y, Hotta T, Saito H, Miyajima A, Arai K, Yokota T. Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor. Biochemical and Biophysical Research Communications. 208: 360-7. PMID 7887951 DOI: 10.1006/Bbrc.1995.1346  0.494
1995 Watanabe S, Kondo M, Takatsu K, Sugamura K, Arai K. Involvement of the interleukin-2 receptor gamma subunit in interleukin-4-dependent activation of mouse hematopoietic cells and splenic B cells. European Journal of Immunology. 25: 126-31. PMID 7843221 DOI: 10.1002/Eji.1830250122  0.353
1995 Watanabe S, Ito Y, Miyajima A, Arai K. Granulocyte macrophage-colony stimulating factor-dependent replication of polyoma virus replicon in hematopoietic cells. Analyses of receptor signals for replication and transcription. Journal of Biological Chemistry. 270: 9615-9621. PMID 7721893 DOI: 10.1074/Jbc.270.16.9615  0.405
1995 Lee HJ, Masuda ES, Arai N, Arai K, Yokota T. Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression. The Journal of Biological Chemistry. 270: 17541-50. PMID 7615560 DOI: 10.1074/Jbc.270.29.17541  0.386
1995 Masai H, Arai K. DnaA-dependent Assembly of the ABC Primosome at the A Site, A Single-stranded DNA Hairpin Containing a DnaA Box Febs Journal. 230: 384-395. PMID 7607206 DOI: 10.1111/J.1432-1033.1995.Tb20573.X  0.333
1994 Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, Sugamura K. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science (New York, N.Y.). 262: 1874-7. PMID 8266076 DOI: 10.1126/Science.8266076  0.332
1994 Nakagawa Y, Kosugi H, Miyajima A, Arai K, Yokota T. Structure of the gene encoding the alpha subunit of the human granulocyte-macrophage colony stimulating factor receptor. Implications for the evolution of the cytokine receptor superfamily. The Journal of Biological Chemistry. 269: 10905-12. PMID 8144676  0.514
1994 Chen JX, Watanabe S, Muto A, Miyajima A, Yokota T, Arai K. Activation of early response genes and cell proliferation by human interleukin-3, granulocyte-macrophage colony-stimulating factor, and interleukin-5 receptors: comparison with human interleukin-4 receptor signaling. The Journal of Allergy and Clinical Immunology. 94: 605-11. PMID 8083468 DOI: 10.1016/0091-6749(94)90136-8  0.385
1994 Lee HJ, Matsuda I, Naito Y, Yokota T, Arai N, Arai K. Signals and nuclear factors that regulate the expression of interleukin-4 and interleukin-5 genes in helper T cells. The Journal of Allergy and Clinical Immunology. 94: 594-604. PMID 8083467 DOI: 10.1016/0091-6749(94)90135-X  0.364
1994 Watanabe S, Yssel H, Harada Y, Arai K. Effects of prostaglandin E2 on Th0-type human T cell clones: modulation of functions of nuclear proteins involved in cytokine production. International Immunology. 6: 523-32. PMID 8018594 DOI: 10.1093/Intimm/6.4.523  0.373
1994 Mui A, Muto A, Sakamaki K, Sato N, Kinoshita T, Watanabe S, Yokota T, Arai K, Miyajima A. Function of the common β subunit of the GM-CSF/IL-3/IL-5 receptors Advances in Experimental Medicine and Biology. 365: 217-223. PMID 7887306 DOI: 10.1007/978-1-4899-0987-9_22  0.371
1994 Nakagawa Y, Arai K. [Diversity and evolution of cytokine receptors]. Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 39: 2591-8. PMID 7855283  0.436
1994 Nishinakamura R, Nakayama N, Inoue T, Hirabayashi Y, Yoshida S, Arai K, Miyajima A, Murray R. Gene disruption of the IL-3/GM-CSF/IL-5 receptor β chains Cytokine. 6: 573. DOI: 10.1016/1043-4666(94)90290-9  0.323
1994 Yokota T, Koyano-Nakagawa N, Nishida J, Arai K. Moloecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the IL-3 promoter Cytokine. 6: 563. DOI: 10.1016/1043-4666(94)90230-5  0.352
1994 Lee HJ, Tsuruta R, Koyano-Nakagawa N, Arai N, Arai K, Yokota T. Differential regulation of the IL-5 and IL-2 genes by cAMP Cytokine. 6: 560. DOI: 10.1016/1043-4666(94)90207-0  0.321
1993 Tokumitsu H, Masuda ES, Tsuboi A, Arai K, Arai N. Purification of the 120 kDa component of the human nuclear factor of activated T cells (NF-AT): reconstitution of binding activity to the cis-acting element of the GM-CSF and IL-2 promoter with AP-1. Biochemical and Biophysical Research Communications. 196: 737-44. PMID 8240350 DOI: 10.1006/Bbrc.1993.2311  0.382
1993 Tomoda T, Murata T, Arai K, Muramatsu M. Mutations on 170Glu, a substrate recognition residue in mouse cAMP-dependent protein kinase, generate enzymes with altered substrate affinity and biological functions Biochimica Et Biophysica Acta. 1175: 333-342. PMID 8094634 DOI: 10.1016/0167-4889(93)90226-F  0.325
1992 Schreurs J, Hung P, May WS, Arai K, Miyajima A. AIC2A is a component of the purified high affinity mouse IL-3 receptor: temperature-dependent modulation of AIC2A structure. International Immunology. 3: 1231-42. PMID 1777419 DOI: 10.1093/Intimm/3.12.1231  0.358
1992 Miyajima A, Kitamura T, Harada N, Yokota T, Arai K. Cytokine receptors and signal transduction. Annual Review of Immunology. 10: 295-331. PMID 1590989 DOI: 10.1146/Annurev.Iy.10.040192.001455  0.374
1992 Muramatsu M, Kaibuchi K, Arai K. Protein kinase C mutants in the auto-inhibitory region exhibit two distinct properties. Febs Letters. 311: 75-9. PMID 1397296 DOI: 10.1016/0014-5793(92)81371-R  0.351
1992 Takaishi T, Morita Y, Hirai K, Yamaguchi M, Yokota T, Arai K, Ito K, Miyamoto T. Mouse IL-3 induces histamine release from mouse peritoneal mast cells. International Archives of Allergy and Immunology. 98: 205-210. PMID 1382745 DOI: 10.1159/000236186  0.304
1992 Nakayama N, Yokota T, Arai K. Use of mammalian cell expression cloning systems to identify genes for cytokines, receptors, and regulatory proteins Current Biology. 2: 644. DOI: 10.1016/0960-9822(92)90109-N  0.357
1991 Yonehara S, Ishii A, Yonehara M, Koyasu S, Miyajima A, Schreurs J, Arai K, Yahara I. Identification of a cell surface 105 kd protein (Aic-2 antigen) which binds interleukin-3. International Immunology. 2: 143-50. PMID 2088482 DOI: 10.1093/Intimm/2.2.143  0.35
1991 Sugimoto K, Tsuboi A, Miyatake S, Arai K, Arai N. Inducible and non-inducible factors co-operatively activate the GM-CSF promoter by interacting with two adjacent DNA motifs. International Immunology. 2: 787-94. PMID 2083235 DOI: 10.1093/Intimm/2.8.787  0.353
1991 Miyatake S, Shlomai J, Arai K, Arai N. Characterization of the mouse granulocyte-macrophage colony-stimulating factor (GM-CSF) gene promoter: nuclear factors that interact with an element shared by three lymphokine genes--those for GM-CSF, interleukin-4 (IL-4), and IL-5. Molecular and Cellular Biology. 11: 5894-901. PMID 1944268 DOI: 10.1128/Mcb.11.12.5894  0.382
1991 Tsuboi A, Sugimoto K, Yodoi J, Miyatake S, Arai K, Arai N. A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B. International Immunology. 3: 807-17. PMID 1911548 DOI: 10.1093/Intimm/3.8.807  0.375
1991 Kitamura T, Sato N, Arai K, Miyajima A. Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors. Cell. 66: 1165-74. PMID 1833064 DOI: 10.1016/0092-8674(91)90039-2  0.356
1991 Kitamura T, Hayashida K, Sakamaki K, Yokota T, Arai K, Miyajima A. Reconstitution of functional receptors for human granulocyte/macrophage colony-stimulating factor (GM-CSF): evidence that the protein encoded by the AIC2B cDNA is a subunit of the murine GM-CSF receptor. Proceedings of the National Academy of Sciences of the United States of America. 88: 5082-6. PMID 1828890 DOI: 10.1073/Pnas.88.12.5082  0.368
1991 Hayashida K, Kitamura T, Gorman DM, Arai K, Yokota T, Miyajima A. Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 9655-9. PMID 1702217 DOI: 10.1073/Pnas.87.24.9655  0.376
1990 Itoh N, Yonehara S, Schreurs J, Gorman DM, Maruyama K, Ishii A, Yahara I, Arai K, Miyajima A. Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family. Science (New York, N.Y.). 247: 324-7. PMID 2404337 DOI: 10.1126/Science.2404337  0.361
1990 Collins MK, Malde P, Miyajima A, Arai K, Smith KA, Mulligan RC. Evidence that the level of the p55 component of the interleukin (IL) 2 receptor can control IL 2 responsiveness in a murine IL 3-dependent cell. European Journal of Immunology. 20: 573-8. PMID 2318250 DOI: 10.1002/Eji.1830200317  0.352
1990 Schreurs J, Arai K, Miyajima A. Evidence for a low-affinity interleukin-3 receptor. Growth Factors (Chur, Switzerland). 2: 221-33. PMID 2187495 DOI: 10.3109/08977199009071508  0.328
1990 Gorman DM, Itoh N, Kitamura T, Schreurs J, Yonehara S, Yahara I, Arai K, Miyajima A. Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family. Proceedings of the National Academy of Sciences of the United States of America. 87: 5459-63. PMID 1695379 DOI: 10.1073/Pnas.87.14.5459  0.401
1990 Nomoto S, Nakayama N, Arai K, Matsumoto K. Regulation of the yeast pheromone response pathway by G protein subunits. The Embo Journal. 9: 691-696. DOI: 10.1002/J.1460-2075.1990.Tb08161.X  0.358
1989 Vercelli D, Jabara HH, Arai K, Yokota T, Geha RS. Endogenous interleukin 6 plays an obligatory role in interleukin 4-dependent human IgE synthesis. European Journal of Immunology. 19: 1419-24. PMID 2789139 DOI: 10.1002/Eji.1830190811  0.333
1989 Muramatsu M, Kaibuchi K, Arai K. A protein kinase C cDNA without the regulatory domain is active after transfection in vivo in the absence of phorbol ester. Molecular and Cellular Biology. 9: 831-6. PMID 2785241 DOI: 10.1128/Mcb.9.2.831  0.357
1989 Kyoasu S, Miyajima A, Arai K, Okajima F, Ui M, Yabar I. Growth regulation of multi-factor-dependent myeloid cell lines: IL-4, TGF-beta and pertussis toxin modulate IL-3- or GM-CSF-induced growth by controlling cell cycle length. Cell Structure and Function. 14: 459-471. PMID 2680112 DOI: 10.1247/Csf.14.459  0.351
1989 Momose H, Arai K, Nakagawa Y, Fujimoto K, Tsujimoto S, Cho M, Tani Y, Saka M, Nakatsuji F, Iwai A. [Neoadjuvant chemoradiotherapy in locally invasive transitional cell carcinoma of the urinary bladder: early results of PVB and CAP therapy]. Hinyokika Kiyo. Acta Urologica Japonica. 35: 781-8. PMID 2478001  0.393
1989 Heike T, Miyatake S, Yoshida M, Arai K, Arai N. Bovine papilloma virus encoded E2 protein activates lymphokine genes through DNA elements, distinct from the consensus motif, in the long control region of its own genome. The Embo Journal. 8: 1411-1417. DOI: 10.1002/J.1460-2075.1989.Tb03522.X  0.383
1988 Collins MK, Downward J, Miyajima A, Maruyama K, Arai K, Mulligan RC. Transfer of functional EGF receptors to an IL3-dependent cell line. Journal of Cellular Physiology. 137: 293-8. PMID 3263970 DOI: 10.1002/Jcp.1041370212  0.399
1988 Pène J, Rousset F, Brière F, Chrétien I, Bonnefoy JY, Spits H, Yokota T, Arai N, Arai K, Banchereau J. IgE production by normal human lymphocytes is induced by interleukin 4 and suppressed by interferons gamma and alpha and prostaglandin E2. Proceedings of the National Academy of Sciences of the United States of America. 85: 6880-4. PMID 2970644 DOI: 10.1073/Pnas.85.18.6880  0.337
1988 Matsumoto K, Nakafuku M, Nakayama N, Miyajima I, Kaibuchi K, Miyajima A, Brenner C, Arai K, Kaziro Y. The role of G proteins in yeast signal transduction Cold Spring Harbor Symposia On Quantitative Biology. 53: 567-575. PMID 2855496 DOI: 10.1101/Sqb.1988.053.01.065  0.559
1988 Matsuki H, Ozono S, Arai K, Saka M, Cho M, Nakagawa Y, Kaneko Y, Yoshida K, Okamoto S, Maruyama Y. [A clinical study of testicular tumors]. Hinyokika Kiyo. Acta Urologica Japonica. 34: 1757-65. PMID 2854363  0.383
1988 Fujisawa J, Seiki M, Toita M, Miyatake S, Arai K, Yoshida M. CELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40tax OF HTLV‐1 Japanese Journal of Cancer Research. 79: 800-804. PMID 2844710 DOI: 10.1111/J.1349-7006.1988.Tb00038.X  0.318
1988 Miyatake S, Seiki M, Malefijt RD, Heike T, Fujisawa J, Takebe Y, Nishida J, Shlomai J, Yokota T, Yoshida M, Arai K, Arai N. Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40x protein and bovine papilloma virus encoded E2 protein. Nucleic Acids Research. 16: 6547-6566. PMID 2840644 DOI: 10.1093/Nar/16.14.6547  0.403
1988 Miyajima A, Miyatake S, Schreurs J, De Vries J, Arai N, Yokota T, Arai K. Coordinate regulation of immune and inflammatory responses by T cell-derived lymphokines. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 2: 2462-73. PMID 2836253 DOI: 10.1096/Fasebj.2.9.2836253  0.348
1988 Nakafuku M, Obara T, Kaibuchi K, Miyajima I, Miyajima A, Itoh H, Nakamura S, Arai K, Matsumoto K, Kaziro Y. Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions Proceedings of the National Academy of Sciences of the United States of America. 85: 1374-1378. PMID 2830616 DOI: 10.1073/Pnas.85.5.1374  0.626
1987 Koike K, Ogawa M, Ihle JN, Miyake T, Shimizu T, Miyajima A, Yokota T, Arai K. Recombinant murine granulocyte-macrophage (GM) colony-stimulating factor supports formation of GM and multipotential blast cell colonies in culture: comparison with the effects of interleukin-3. Journal of Cellular Physiology. 131: 458-64. PMID 3298286 DOI: 10.1002/Jcp.1041310319  0.351
1987 Masai H, Arai K. RepA and DnaA proteins are required for initiation of R1 plasmid replication in vitro and interact with the oriR sequence Proceedings of the National Academy of Sciences of the United States of America. 84: 4781-4785. PMID 3037524 DOI: 10.1073/Pnas.84.14.4781  0.316
1987 Otsuka T, Villaret D, Yokota T, Takebe Y, Lee F, Arai N, Arai K. Structural analysis of the mouse chromosomal gene encoding interleukin 4 which expresses B cell, T cell and mast cell stimulating activities Nucleic Acids Research. 15: 333-344. PMID 3029676 DOI: 10.1093/Nar/15.1.333  0.408
1987 Cabrillat H, Galizzi J, Djossou O, Arai N, Yokota T, Arai K, Banchereau J. High affinity binding of human interleukin 4 to cell lines. Biochemical and Biophysical Research Communications. 149: 995-1001. PMID 2962580 DOI: 10.1016/0006-291X(87)90507-9  0.36
1987 Defrance T, Aubry JP, Rousset F, Vanbervliet B, Bonnefoy JY, Arai N, Takebe Y, Yokota T, Lee F, Arai K. Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes. The Journal of Experimental Medicine. 165: 1459-67. PMID 2953844 DOI: 10.1084/Jem.165.6.1459  0.333
1986 Koiwai O, Yokota T, Kageyama T, Hirose T, Yoshida S, Arai K. Isolation and characterization of bovine and mouse terminal deoxynucleotidyltransferase cDNAs expressible in mammalian cells. Nucleic Acids Research. 14: 5777-92. PMID 3755527 DOI: 10.1093/Nar/14.14.5777  0.318
1986 Yokota T, Otsuka T, Mosmann T, Banchereau J, DeFrance T, Blanchard D, De Vries JE, Lee F, Arai K. Isolation and characterization of a human interleukin cDNA clone, homologous to mouse B-cell stimulatory factor 1, that expresses B-cell- and T-cell-stimulating activities. Proceedings of the National Academy of Sciences of the United States of America. 83: 5894-8. PMID 3016727 DOI: 10.1073/Pnas.83.16.5894  0.363
1986 Masai H, Bond MW, Arai K. Cloning of the Escherichia coli gene for primosomal protein i: the relationship to dnaT, essential for chromosomal DNA replication Proceedings of the National Academy of Sciences of the United States of America. 83: 1256-1260. PMID 3006041 DOI: 10.1073/Pnas.83.5.1256  0.335
1986 MIYAJIMA A, YOKOTA T, TAKEBE Y, OHTSUKA T, ARAI N, ARAI K. Cloning, Expression and Characterization of T-cell Derived Lymphokine Genes Juntendo Medical Journal. 32: 442-444. DOI: 10.14789/Pjmj.32.442  0.31
1986 Miyajima A, Otsu K, Schreurs J, Bond M, Abrams J, Arai K. Expression of murine and human granulocyte-macrophage colony-stimulating factors in S. cerevisiae: mutagenesis of the potential glycosylation sites. The Embo Journal. 5: 1193-1197. DOI: 10.1002/J.1460-2075.1986.Tb04346.X  0.365
1985 Lee F, Yokota T, Otsuka T, Gemmell L, Larson N, Luh J, Arai K, Rennick D. Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 4360-4. PMID 3925454 DOI: 10.1073/Pnas.82.13.4360  0.356
1985 Miyatake S, Yokota T, Lee F, Arai K. Structure of the chromosomal gene for murine interleukin 3. Proceedings of the National Academy of Sciences of the United States of America. 82: 316-20. PMID 3918308 DOI: 10.1073/Pnas.82.2.316  0.351
1985 Yokota T, Arai N, Lee F, Rennick D, Mosmann T, Arai K. Use of a cDNA expression vector for isolation of mouse interleukin 2 cDNA clones: expression of T-cell growth-factor activity after transfection of monkey cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 68-72. PMID 3918306 DOI: 10.1073/Pnas.82.1.68  0.373
1985 Miyajima A, Bond MW, Otsu K, Arai K, Arai N. Secretion of mature mouse interleukin-2 by Saccharomyces cerevisiae: use of a general secretion vector containing promoter and leader sequences of the mating pheromone alpha-factor. Gene. 37: 155-61. PMID 3902570 DOI: 10.1016/0378-1119(85)90268-9  0.385
1985 Miyatake S, Otsuka T, Yokota T, Lee F, Arai K. Structure of the chromosomal gene for granulocyte-macrophage colony stimulating factor: comparison of the mouse and human genes. The Embo Journal. 4: 2561-2568. DOI: 10.1002/J.1460-2075.1985.Tb03971.X  0.348
1984 Yokota T, Lee F, Rennick D, Hall C, Arai N, Mosmann T, Nabel G, Cantor H, Arai K. Isolation and characterization of a mouse cDNA clone that expresses mast-cell growth-factor activity in monkey cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 1070-4. PMID 6322187 DOI: 10.1073/Pnas.81.4.1070  0.338
1983 Masai H, Kaziro Y, Arai K. Definition of oriR, the minimum DNA segment essential for initiation of R1 plasmid replication in vitro Proceedings of the National Academy of Sciences of the United States of America. 80: 6814-6818. PMID 6316326 DOI: 10.1073/Pnas.80.22.6814  0.315
1976 Arai KI, Nakamura S, Arai T, Kawakita M, Kaziro Y. Limited hydrolysis of the polypeptide chain elongation factor Tu by trypsin. Isolation and characterization of the polypeptide fragments Journal of Biochemistry. 79: 69-83. PMID 939763 DOI: 10.1093/Oxfordjournals.Jbchem.A131060  0.301
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