| Year |
Citation |
Score |
| 2023 |
Ejdrup AL, Wellbourne-Wood J, Dreyer JK, Guldhammer N, Lycas MD, Gether U, Hall BJ, Sørensen G. Within-Mice Comparison of Microdialysis and Fiber Photometry-Recorded Dopamine Biosensor during Amphetamine Response. Acs Chemical Neuroscience. PMID 37043174 DOI: 10.1021/acschemneuro.2c00817 |
0.739 |
|
| 2023 |
Jørgensen SH, Ejdrup AL, Lycas MD, Posselt LP, Madsen KL, Tian L, Dreyer JK, Herborg F, Sørensen AT, Gether U. Behavioral encoding across timescales by region-specific dopamine dynamics. Proceedings of the National Academy of Sciences of the United States of America. 120: e2215230120. PMID 36749722 DOI: 10.1073/pnas.2215230120 |
0.739 |
|
| 2022 |
Lycas MD, Ejdrup AL, Sørensen AT, Haahr NO, Jørgensen SH, Guthrie DA, Støier JF, Werner C, Newman AH, Sauer M, Herborg F, Gether U. Nanoscopic dopamine transporter distribution and conformation are inversely regulated by excitatory drive and D2 autoreceptor activity. Cell Reports. 40: 111431. PMID 36170827 DOI: 10.1016/j.celrep.2022.111431 |
0.785 |
|
| 2022 |
Ejdrup AL, Lycas MD, Lorenzen N, Konomi A, Herborg F, Madsen KL, Gether U. A density-based enrichment measure for assessing colocalization in single-molecule localization microscopy data. Nature Communications. 13: 4388. PMID 35902578 DOI: 10.1038/s41467-022-32064-y |
0.706 |
|
| 2022 |
Toschi C, El-Sayed Hervig M, Burghi T, Sell T, Lycas MD, Moazen P, Huang L, Gether U, Robbins TW, Dalley JW. Dissociating reward sensitivity and negative urgency effects on impulsivity in the five-choice serial reaction time task. Brain and Neuroscience Advances. 6: 23982128221102256. PMID 35721835 DOI: 10.1177/23982128221102256 |
0.695 |
|
| 2022 |
Andersen RC, Schmidt JH, Rombach J, Lycas MD, Christensen NR, Lund VK, Stapleton DS, Pedersen SS, Olsen MA, Stoklund M, Noes-Holt G, Nielsen TT, Keller MP, Jansen AM, Herlo R, ... ... Gether U, et al. Coding variants identified in diabetic patients alter PICK1 BAR domain function in insulin granule biogenesis. The Journal of Clinical Investigation. PMID 35077398 DOI: 10.1172/JCI144904 |
0.713 |
|
| 2021 |
Sørensen G, Rickhag M, Leo D, Lycas MD, Ridderstrøm PH, Weikop P, Lilja JH, Rifes P, Herborg F, Woldbye D, Wörtwein G, Gainetdinov RR, Fink-Jensen A, Gether U. Disruption of the PDZ-domain binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis and reward motivation. The Journal of Biological Chemistry. 101361. PMID 34756883 DOI: 10.1016/j.jbc.2021.101361 |
0.77 |
|
| 2021 |
Herborg F, Jensen KL, Tolstoy S, Arends NV, Posselt LP, Shekar A, Aguilar JI, Lund VK, Erreger K, Rickhag M, Lycas MD, Lonsdale MN, Rahbek-Clemmensen T, Sørensen AT, Newman AH, ... ... Gether U, et al. Dominant-negative actions of a dopamine transporter variant identified in patients with parkinsonism and neuropsychiatric disease. Jci Insight. PMID 34375312 DOI: 10.1172/jci.insight.151496 |
0.76 |
|
| 2021 |
Gether U, Sitte HH. It takes two-or more-to tango: Revisiting the role of dopamine transporter oligomerization. The Journal of Biological Chemistry. 296: 100629. PMID 34237901 DOI: 10.1016/j.jbc.2021.100629 |
0.332 |
|
| 2021 |
Lund VK, Lycas MD, Schack A, Andersen RC, Gether U, Kjaerulff O. Rab2 drives axonal transport of dense core vesicles and lysosomal organelles. Cell Reports. 35: 108973. PMID 33852866 DOI: 10.1016/j.celrep.2021.108973 |
0.719 |
|
| 2020 |
Guthrie D, Klein Herenbrink C, Lycas M, Ku T, Bonifazi A, DeVree B, Mathiasen S, Javitch J, Grimm JB, Lavis LD, Gether U, Newman AH. Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter. Acs Chemical Neuroscience. PMID 32926777 DOI: 10.1021/Acschemneuro.0C00397 |
0.767 |
|
| 2020 |
Jensen ME, Galli A, Thomsen M, Jensen KL, Thomsen GK, Klausen MK, Vilsbøll T, Christensen MB, Holst JJ, Owens A, Robertson S, Daws L, Zanella D, Gether U, Knudsen GM, et al. Glucagon-like peptide-1 receptor regulation of basal dopamine transporter activity is species-dependent. Neurochemistry International. 104772. PMID 32464226 DOI: 10.1016/J.Neuint.2020.104772 |
0.379 |
|
| 2020 |
Christensen NR, De Luca M, Lever MB, Richner M, Hansen AB, Noes-Holt G, Jensen KL, Rathje M, Jensen DB, Erlendsson S, Bartling CR, Ammendrup-Johnsen I, Pedersen SE, Schönauer M, Nissen KB, ... ... Gether U, et al. A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain. Embo Molecular Medicine. e11248. PMID 32352640 DOI: 10.15252/Emmm.201911248 |
0.306 |
|
| 2020 |
Plenge P, Abramyan AM, Sørensen G, Mørk A, Weikop P, Gether U, Bang-Andersen B, Shi L, Loland CJ. The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter. Nature Communications. 11: 1491. PMID 32198394 DOI: 10.1038/S41467-020-15292-Y |
0.34 |
|
| 2020 |
Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, Missel JW, LeVine MV, Gourdon P, Blanchard SC, Javitch JA, Weinstein H, Loland CJ, Nissen P, Gether U. X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release. Nature Communications. 11: 1005. PMID 32081981 DOI: 10.1038/S41467-020-14735-W |
0.334 |
|
| 2019 |
Giguère N, Delignat-Lavaud B, Herborg F, Voisin A, Li Y, Jacquemet V, Anand-Srivastava M, Gether U, Giros B, Trudeau LÉ. Increased vulnerability of nigral dopamine neurons after expansion of their axonal arborization size through D2 dopamine receptor conditional knockout. Plos Genetics. 15: e1008352. PMID 31449520 DOI: 10.1371/Journal.Pgen.1008352 |
0.337 |
|
| 2019 |
Runegaard AH, Dencker D, Wörtwein G, Gether U. G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization. Neuropharmacology. PMID 31173760 DOI: 10.1016/J.Neuropharm.2019.06.002 |
0.402 |
|
| 2019 |
DiCarlo GE, Aguilar JI, Matthies HJ, Harrison FE, Bundschuh KE, West A, Hashemi P, Herborg F, Rickhag M, Chen H, Gether U, Wallace MT, Galli A. Autism-linked dopamine transporter mutation alters striatal dopamine neurotransmission and dopamine-dependent behaviors. The Journal of Clinical Investigation. 130. PMID 31094705 DOI: 10.1172/Jci127411 |
0.425 |
|
| 2019 |
Möller IR, Slivacka M, Nielsen AK, Rasmussen SGF, Gether U, Loland CJ, Rand KD. Conformational dynamics of the human serotonin transporter during substrate and drug binding. Nature Communications. 10: 1687. PMID 30976000 DOI: 10.1038/S41467-019-09675-Z |
0.369 |
|
| 2019 |
Runegaard AH, Fitzpatrick CM, Woldbye DPD, Andreasen JT, Sørensen AT, Gether U. Modulating Dopamine Signaling and Behavior with Chemogenetics: Concepts, Progress, and Challenges. Pharmacological Reviews. 71: 123-156. PMID 30814274 DOI: 10.1124/Pr.117.013995 |
0.382 |
|
| 2019 |
Kønig AB, Ciriachi C, Gether U, Rickhag M. Chemogenetic Targeting of Dorsomedial Direct-pathway Striatal Projection Neurons Selectively Elicits Rotational Behavior in Mice. Neuroscience. PMID 30668973 DOI: 10.1016/J.Neuroscience.2019.01.013 |
0.326 |
|
| 2019 |
Erlendsson S, Thorsen TS, Vauquelin G, Ammendrup-Johnsen I, Wirth V, Martinez KL, Teilum K, Gether U, Madsen KL. Mechanisms of PDZ domain scaffold assembly illuminated by use of supported cell membrane sheets. Elife. 8. PMID 30605082 DOI: 10.7554/Elife.39180 |
0.363 |
|
| 2019 |
Abramyan AM, Plenge P, Weikop P, Gether U, Bang-Andersen B, Shi L, Løland CJ. Mechanistic Characterization of the Allosteric Communications between the Central Binding Site and the Extracellular Vestibule of the Serotonin Transporter Biophysical Journal. 116: 557a. DOI: 10.1016/J.Bpj.2018.11.2995 |
0.34 |
|
| 2018 |
Fitzpatrick CM, Runegaard AH, Christiansen SH, Hansen NW, Jørgensen SH, McGirr JC, de Diego Ajenjo A, Sørensen AT, Perrier JF, Petersen A, Gether U, Woldbye DPD, Andreasen JT. Differential effects of chemogenetic inhibition of dopamine and norepinephrine neurons in the mouse 5-choice serial reaction time task. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 90: 264-276. PMID 30529002 DOI: 10.1016/J.Pnpbp.2018.12.004 |
0.348 |
|
| 2018 |
Runegaard AH, Jensen KL, Wörtwein G, Gether U. Initial rewarding effects of cocaine and amphetamine assessed in a day using the single exposure place preference protocol. The European Journal of Neuroscience. PMID 30044020 DOI: 10.1111/Ejn.14082 |
0.32 |
|
| 2018 |
Mayer FP, Schmid D, Owens WA, Gould GG, Apuschkin M, Kudlacek O, Salzer I, Boehm S, Chiba P, Williams PH, Wu HH, Gether U, Koek W, Daws LC, Sitte HH. An unsuspected role for organic cation transporter 3 in the actions of amphetamine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29773909 DOI: 10.1038/S41386-018-0053-5 |
0.409 |
|
| 2018 |
Herlo R, Lund VK, Lycas MD, Jansen AM, Khelashvili G, Andersen RC, Bhatia V, Pedersen TS, Albornoz PBC, Johner N, Ammendrup-Johnsen I, Christensen NR, Erlendsson S, Stoklund M, Larsen JB, ... ... Gether U, et al. An Amphipathic Helix Directs Cellular Membrane Curvature Sensing and Function of the BAR Domain Protein PICK1. Cell Reports. 23: 2056-2069. PMID 29768204 DOI: 10.1016/J.Celrep.2018.04.074 |
0.74 |
|
| 2018 |
Merkle PS, Gotfryd K, Cuendet MA, Leth-Espensen KZ, Gether U, Loland CJ, Rand KD. Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT. Science Advances. 4: eaar6179. PMID 29756037 DOI: 10.1126/Sciadv.Aar6179 |
0.341 |
|
| 2018 |
Herborg F, Andreassen TF, Berlin F, Loland CJ, Gether U. Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes. The Journal of Biological Chemistry. PMID 29559554 DOI: 10.1074/Jbc.Ra118.001753 |
0.408 |
|
| 2017 |
Jensen KL, Runegaard AH, Weikop P, Gether U, Rickhag M. Assessment of Dopaminergic Homeostasis in Mice by Use of High-performance Liquid Chromatography Analysis and Synaptosomal Dopamine Uptake. Journal of Visualized Experiments : Jove. PMID 28994779 DOI: 10.3791/56093 |
0.392 |
|
| 2017 |
Rahbek-Clemmensen T, Lycas MD, Erlendsson S, Eriksen J, Apuschkin M, Vilhardt F, Jørgensen TN, Hansen FH, Gether U. Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains. Nature Communications. 8: 740. PMID 28963530 DOI: 10.1038/S41467-017-00790-3 |
0.778 |
|
| 2017 |
Runegaard AH, Jensen KL, Dencker D, Wörtwein G, Gether U. Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm. Journal of Neuroscience Methods. 289: 85-92. PMID 28711378 DOI: 10.1016/J.Jneumeth.2017.07.010 |
0.331 |
|
| 2017 |
Jørgensen SH, Fitzpatrick CM, Gether U, Woldbye DDP, Sørensen AT. Chemogenetic Modulation of G Protein-Coupled Receptor Signalling in Visual Attention Research. Basic & Clinical Pharmacology & Toxicology. PMID 28609587 DOI: 10.1111/Bcpt.12819 |
0.302 |
|
| 2017 |
Jacobsen SE, Gether U, Bräuner-Osborne H. Investigating the molecular mechanism of positive and negative allosteric modulators in the calcium-sensing receptor dimer. Scientific Reports. 7: 46355. PMID 28417952 DOI: 10.1038/Srep46355 |
0.321 |
|
| 2017 |
Jacobsen SE, Ammendrup-Johnsen I, Jansen AM, Gether U, Madsen KL, Bräuner-Osborne H. The GPRC6A Receptor displays Constitutive Internalization and Sorting to the Slow Recycling Pathway. The Journal of Biological Chemistry. PMID 28280242 DOI: 10.1074/Jbc.M116.762385 |
0.332 |
|
| 2017 |
Erlendsson S, Gotfryd K, Larsen FH, Mortensen JS, Geiger MA, van Rossum BJ, Oschkinat H, Gether U, Teilum K, Loland CJ. Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR. Elife. 6. PMID 28117663 DOI: 10.7554/Elife.19314 |
0.338 |
|
| 2016 |
Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T. The Environment Shapes the Inner Vestibule of LeuT. Plos Computational Biology. 12: e1005197. PMID 27835643 DOI: 10.1371/Journal.Pcbi.1005197 |
0.328 |
|
| 2016 |
Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ. Transition metal ion FRET uncovers K(+) regulation of a neurotransmitter/sodium symporter. Nature Communications. 7: 12755. PMID 27678200 DOI: 10.1038/Ncomms12755 |
0.315 |
|
| 2016 |
Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H. Conformational dynamics on the extracellular side of LeuT controlled by Na+ and K+ ions and the protonation state of E290. The Journal of Biological Chemistry. PMID 27474737 DOI: 10.1074/Jbc.M116.731455 |
0.33 |
|
| 2016 |
Runegaard AH, Jensen KL, Fitzpatrick CM, Dencker D, Weikop P, Gether U, Rickhag M. Preserved dopaminergic homeostasis and dopamine-related behaviour in hemizygous TH-Cre mice. The European Journal of Neuroscience. PMID 27453291 DOI: 10.1111/Ejn.13347 |
0.368 |
|
| 2016 |
Caron MG, Gether U. Structural biology: Antidepressants at work. Nature. PMID 27049942 DOI: 10.1038/Nature17883 |
0.342 |
|
| 2016 |
Vuorenpää A, Ammendrup-Johnsen I, Jørgensen TN, Gether U. A kinome wide screen identifies novel kinases involved in regulation of monoamine transporter function. Neurochemistry International. PMID 27020406 DOI: 10.1016/J.Neuint.2016.03.013 |
0.355 |
|
| 2016 |
Vuorenpää A, Jørgensen TN, Newman AH, Madsen KL, Scheinin M, Gether U. Differential internalization rates and postendocytic sorting of the norepinephrine and dopamine transporters are controlled by structural elements in the N-termini. The Journal of Biological Chemistry. PMID 26786096 DOI: 10.1074/Jbc.M115.702050 |
0.435 |
|
| 2015 |
Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ. Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter. British Journal of Pharmacology. PMID 26699847 DOI: 10.1111/Bph.13411 |
0.31 |
|
| 2015 |
Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U. Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter. The Journal of Biological Chemistry. PMID 26363074 DOI: 10.1074/Jbc.M115.677658 |
0.366 |
|
| 2015 |
Apuschkin M, Stilling S, Rahbek-Clemmensen T, Sørensen G, Fortin G, Herborg Hansen F, Eriksen J, Trudeau LE, Egerod K, Gether U, Rickhag M. A novel dopamine transporter transgenic mouse line for identification and purification of midbrain dopaminergic neurons reveals midbrain heterogeneity. The European Journal of Neuroscience. 42: 2438-54. PMID 26286107 DOI: 10.1111/Ejn.13046 |
0.378 |
|
| 2015 |
Karlsen ML, Thorsen TS, Johner N, Ammendrup-Johnsen I, Erlendsson S, Tian X, Simonsen JB, Høiberg-Nielsen R, Christensen NM, Khelashvili G, Streicher W, Teilum K, Vestergaard B, Weinstein H, Gether U, et al. Structure of Dimeric and Tetrameric Complexes of the BAR Domain Protein PICK1 Determined by Small-Angle X-Ray Scattering. Structure (London, England : 1993). PMID 26073603 DOI: 10.1016/J.Str.2015.04.020 |
0.313 |
|
| 2015 |
Steinkellner T, Montgomery TR, Hofmaier T, Kudlacek O, Yang JW, Rickhag M, Jung G, Lubec G, Gether U, Freissmuth M, Sitte HH. Amphetamine action at the cocaine- and antidepressant-sensitive serotonin transporter is modulated by αCaMKII. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 8258-71. PMID 26019340 DOI: 10.1523/Jneurosci.4034-14.2015 |
0.413 |
|
| 2015 |
Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L. Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters. The Journal of Biological Chemistry. 290: 13992-4003. PMID 25869126 DOI: 10.1074/Jbc.M114.625343 |
0.403 |
|
| 2015 |
Cartier E, Hamilton PJ, Belovich AN, Shekar A, Campbell NG, Saunders C, Andreassen TF, Gether U, Veenstra-Vanderweele J, Sutcliffe JS, Ulery-Reynolds PG, Erreger K, Matthies HJ, Galli A. Rare autism-associated variants implicate syntaxin 1 (STX1 R26Q) phosphorylation and the dopamine transporter (hDAT R51W) in dopamine neurotransmission and behaviors. Ebiomedicine. 2: 135-146. PMID 25774383 DOI: 10.1016/J.Ebiom.2015.01.007 |
0.452 |
|
| 2015 |
Rajamanickam J, Annamalai B, Rahbek-Clemmensen T, Sundaramurthy S, Gether U, Jayanthi LD, Ramamoorthy S. Akt-mediated regulation of antidepressant-sensitive serotonin transporter function, cell-surface expression and phosphorylation. The Biochemical Journal. 468: 177-90. PMID 25761794 DOI: 10.1042/Bj20140826 |
0.31 |
|
| 2014 |
Pinheiro PS, Jansen AM, de Wit H, Tawfik B, Madsen KL, Verhage M, Gether U, Sørensen JB. The BAR domain protein PICK1 controls vesicle number and size in adrenal chromaffin cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 10688-700. PMID 25100601 DOI: 10.1523/Jneurosci.5132-13.2014 |
0.346 |
|
| 2014 |
Borre L, Andreassen TF, Shi L, Weinstein H, Gether U. The second sodium site in the dopamine transporter controls cation permeation and is regulated by chloride. The Journal of Biological Chemistry. 289: 25764-73. PMID 25063810 DOI: 10.1074/Jbc.M114.574269 |
0.394 |
|
| 2014 |
Erlendsson S, Rathje M, Heidarsson PO, Poulsen FM, Madsen KL, Teilum K, Gether U. Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands. The Journal of Biological Chemistry. 289: 25327-40. PMID 25023278 DOI: 10.1074/Jbc.M114.548743 |
0.364 |
|
| 2014 |
Rahbek-Clemmensen T, Bay T, Eriksen J, Gether U, Jørgensen TN. The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. The Journal of Biological Chemistry. 289: 23004-19. PMID 24973209 DOI: 10.1074/Jbc.M113.495754 |
0.408 |
|
| 2014 |
Kumar V, Rahbek-Clemmensen T, Billesbølle CB, Jorgensen TN, Gether U, Newman AH. Novel and high affinity fluorescent ligands for the serotonin transporter based on (s)-citalopram. Acs Medicinal Chemistry Letters. 5: 696-9. PMID 24944746 DOI: 10.1021/Ml5000806 |
0.384 |
|
| 2014 |
Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, ... ... Gether U, et al. Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. The Journal of Clinical Investigation. 124: 3107-20. PMID 24911152 DOI: 10.1172/Jci73778 |
0.395 |
|
| 2014 |
Steinkellner T, Mus L, Eisenrauch B, Constantinescu A, Leo D, Konrad L, Rickhag M, Sørensen G, Efimova EV, Kong E, Willeit M, Sotnikova TD, Kudlacek O, Gether U, Freissmuth M, et al. In vivo amphetamine action is contingent on αCaMKII. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2681-93. PMID 24871545 DOI: 10.1038/Npp.2014.124 |
0.433 |
|
| 2013 |
Hamilton PJ, Campbell NG, Sharma S, Erreger K, Hansen FH, Saunders C, Belovich AN, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A. Drosophila melanogaster: a novel animal model for the behavioral characterization of autism-associated mutations in the dopamine transporter gene. Molecular Psychiatry. 18: 1235. PMID 24253181 DOI: 10.1038/Mp.2013.157 |
0.358 |
|
| 2013 |
Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH. Novel tripod amphiphiles for membrane protein analysis. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 15645-51. PMID 24123610 DOI: 10.1002/Chem.201301423 |
0.304 |
|
| 2013 |
Hamilton PJ, Campbell NG, Sharma S, Erreger K, Herborg Hansen F, Saunders C, Belovich AN, Sahai MA, Cook EH, Gether U, McHaourab HS, Matthies HJ, Sutcliffe JS, Galli A. De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder. Molecular Psychiatry. 18: 1315-23. PMID 23979605 DOI: 10.1038/mp.2013.102 |
0.347 |
|
| 2013 |
Rickhag M, Owens WA, Winkler MT, Strandfelt KN, Rathje M, Sørensen G, Andresen B, Madsen KL, Jørgensen TN, Wörtwein G, Woldbye DP, Sitte H, Daws LC, Gether U. Membrane-permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release. The Journal of Biological Chemistry. 288: 27534-44. PMID 23884410 DOI: 10.1074/Jbc.M112.441295 |
0.457 |
|
| 2013 |
Holst B, Madsen KL, Jansen AM, Jin C, Rickhag M, Lund VK, Jensen M, Bhatia V, Sørensen G, Madsen AN, Xue Z, Møller SK, Woldbye D, Qvortrup K, Huganir R, ... ... Gether U, et al. PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance. Plos Biology. 11: e1001542. PMID 23630454 DOI: 10.1371/Journal.Pbio.1001542 |
0.326 |
|
| 2013 |
Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, ... Gether U, et al. A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter. Nature Communications. 4: 1580. PMID 23481388 DOI: 10.1038/Ncomms2568 |
0.466 |
|
| 2013 |
Simmons KJ, Gotfryd K, Billesbølle CB, Loland CJ, Gether U, Fishwick CW, Johnson AP. A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT. Molecular Membrane Biology. 30: 184-94. PMID 22908980 DOI: 10.3109/09687688.2012.710341 |
0.343 |
|
| 2013 |
Rickhag M, Herborg Hansen F, Sørensen G, Nørgaard Strandfelt K, Andresen B, Gotfryd K, Madsen KL, Vestergaard Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer E, Gomeza J, Woldbye DP, Wörtwein G, ... Gether U, et al. Erratum: Corrigendum: A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter Nature Communications. 4. DOI: 10.1038/Ncomms3589 |
0.416 |
|
| 2013 |
Karlsen ML, Madsen KL, Stamou D, Qvortrup K, Gether U. Biochemical and Biophysical Studies of Membrane Deformation by Bar-Domain Proteins Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.562 |
0.347 |
|
| 2013 |
Herlo R, Ammendrup-Johnsen I, Madsen KL, Stamou D, Gether U. Phosphorylation of the Amphipathic Helix Changes the Lipid Binding Capacities of PICK1 Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.3302 |
0.377 |
|
| 2013 |
Erlendsson S, Thorsen TS, Rathje M, Madsen KL, Gether U. Avidity of Scaffolding Interactions Studied on Inverted Membrane Sheets Using the Synaptic Scaffolding Protein PICK1 Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.3089 |
0.392 |
|
| 2012 |
Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ. Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter. The Journal of Biological Chemistry. 287: 39316-26. PMID 23007398 DOI: 10.1074/Jbc.M112.371765 |
0.351 |
|
| 2012 |
Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH. A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 9485-90. PMID 22730191 DOI: 10.1002/Chem.201200069 |
0.306 |
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| 2012 |
Bröer S, Gether U. The solute carrier 6 family of transporters. British Journal of Pharmacology. 167: 256-78. PMID 22519513 DOI: 10.1111/J.1476-5381.2012.01975.X |
0.317 |
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| 2012 |
Madsen KL, Thorsen TS, Rahbek-Clemmensen T, Eriksen J, Gether U. Protein interacting with C kinase 1 (PICK1) reduces reinsertion rates of interaction partners sorted to Rab11-dependent slow recycling pathway. The Journal of Biological Chemistry. 287: 12293-308. PMID 22303009 DOI: 10.1074/Jbc.M111.294702 |
0.367 |
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| 2012 |
Ammendrup-Johnsen I, Thorsen TS, Gether U, Madsen KL. Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding. Biochemistry. 51: 586-96. PMID 22129425 DOI: 10.1021/Bi2014689 |
0.319 |
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| 2012 |
Steinkellner T, Montgomery T, Yang J, Rickhag M, Sucic S, Elgersma Y, Kudlacek O, Freissmuth M, Gether U, Sitte HH. Calmodulin kinase II regulates amphetamine-induced reverse transport in dopamine and serotonin transporters Bmc Pharmacology and Toxicology. 13. DOI: 10.1186/2050-6511-13-S1-A56 |
0.44 |
|
| 2012 |
Tutkus M, Mathiensen S, Kruger DB, Tonnesen A, Gether U, Loland CJ, Stamou D. Conformational Dynamics of Lipid-Reconstituted LeuT Studied at the Single Vesicle and Single Molecule Level Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.307 |
0.351 |
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| 2011 |
Vaz SH, Jørgensen TN, Cristóvão-Ferreira S, Duflot S, Ribeiro JA, Gether U, Sebastião AM. Brain-derived neurotrophic factor (BDNF) enhances GABA transport by modulating the trafficking of GABA transporter-1 (GAT-1) from the plasma membrane of rat cortical astrocytes. The Journal of Biological Chemistry. 286: 40464-76. PMID 21969376 DOI: 10.1074/Jbc.M111.232009 |
0.328 |
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| 2011 |
Kristensen AS, Andersen J, Jørgensen TN, Sørensen L, Eriksen J, Loland CJ, Strømgaard K, Gether U. SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacological Reviews. 63: 585-640. PMID 21752877 DOI: 10.1124/Pr.108.000869 |
0.419 |
|
| 2011 |
Thorsen TS, Madsen KL, Dyhring T, Bach A, Peters D, Strømgaard K, Rønn LC, Gether U. A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain. Combinatorial Chemistry & High Throughput Screening. 14: 590-600. PMID 21534917 DOI: 10.2174/138620711796367201 |
0.336 |
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| 2011 |
Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. The binding sites for benztropines and dopamine in the dopamine transporter overlap. Neuropharmacology. 60: 182-90. PMID 20816875 DOI: 10.1016/J.Neuropharm.2010.08.021 |
0.409 |
|
| 2010 |
Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, ... Gether U, et al. Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins. Nature Methods. 7: 1003-8. PMID 21037590 DOI: 10.1038/Nmeth.1526 |
0.303 |
|
| 2010 |
Bach A, Stuhr-Hansen N, Thorsen TS, Bork N, Moreira IS, Frydenvang K, Padrah S, Christensen SB, Madsen KL, Weinstein H, Gether U, Strømgaard K. Structure-activity relationships of a small-molecule inhibitor of the PDZ domain of PICK1 Organic and Biomolecular Chemistry. 8: 4281-4288. PMID 20668766 DOI: 10.1039/C0Ob00025F |
0.314 |
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| 2010 |
Eriksen J, Bjørn-Yoshimoto WE, Jørgensen TN, Newman AH, Gether U. Postendocytic sorting of constitutively internalized dopamine transporter in cell lines and dopaminergic neurons. The Journal of Biological Chemistry. 285: 27289-301. PMID 20551317 DOI: 10.1074/Jbc.M110.131003 |
0.458 |
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| 2010 |
Madsen KL, Bhatia VK, Gether U, Stamou D. BAR domains, amphipathic helices and membrane‐anchored proteins use the same mechanism to sense membrane curvature Febs Letters. 584: 1848-1855. PMID 20122931 DOI: 10.1016/J.Febslet.2010.01.053 |
0.343 |
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| 2010 |
Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of Biological Chemistry. 285: 10924-38. PMID 20118234 DOI: 10.1074/Jbc.M109.083154 |
0.42 |
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| 2010 |
Eriksen J, Jørgensen TN, Gether U. Regulation of dopamine transporter function by protein-protein interactions: new discoveries and methodological challenges. Journal of Neurochemistry. 113: 27-41. PMID 20085610 DOI: 10.1111/J.1471-4159.2010.06599.X |
0.451 |
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| 2010 |
Thorsen TS, Madsen KL, Rebola N, Rathje M, Anggono V, Bach A, Moreira IS, Stuhr-Hansen N, Dyhring T, Peters D, Beuming T, Huganir R, Weinstein H, Mulle C, Strømgaard K, ... ... Gether U, et al. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proceedings of the National Academy of Sciences of the United States of America. 107: 413-8. PMID 20018661 DOI: 10.1073/Pnas.0902225107 |
0.348 |
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| 2010 |
Moreira I, Ge X, Madsen KL, Gether U, Weinstein H. Design and Characterization of Small Molecule Inhibitors of the PICK1 PDZ Domain with Binding Free Energy Calculations Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2319 |
0.333 |
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| 2009 |
Bhatia VK, Madsen KL, Bolinger PY, Kunding A, Hedegård P, Gether U, Stamou D. Amphipathic motifs in BAR domains are essential for membrane curvature sensing. The Embo Journal. 28: 3303-14. PMID 19816406 DOI: 10.1038/Emboj.2009.261 |
0.33 |
|
| 2009 |
Jansen AM, Nässel DR, Madsen KL, Jung AG, Gether U, Kjaerulff O. PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system. The Journal of Comparative Neurology. 517: 313-32. PMID 19757495 DOI: 10.1002/Cne.22155 |
0.352 |
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| 2009 |
Hatzakis NS, Bhatia VK, Larsen J, Madsen KL, Bolinger PY, Kunding AH, Castillo J, Gether U, Hedegård P, Stamou D. How curved membranes recruit amphipathic helices and protein anchoring motifs. Nature Chemical Biology. 5: 835-41. PMID 19749743 DOI: 10.1038/Nchembio.213 |
0.331 |
|
| 2009 |
Rasmussen TN, Plenge P, Bay T, Egebjerg J, Gether U. A single nucleotide polymorphism in the human serotonin transporter introduces a new site for N-linked glycosylation. Neuropharmacology. 57: 287-94. PMID 19500602 DOI: 10.1016/J.Neuropharm.2009.05.009 |
0.342 |
|
| 2009 |
Eriksen J, Rasmussen SG, Rasmussen TN, Vaegter CB, Cha JH, Zou MF, Newman AH, Gether U. Visualization of dopamine transporter trafficking in live neurons by use of fluorescent cocaine analogs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 6794-808. PMID 19474307 DOI: 10.1523/Jneurosci.4177-08.2009 |
0.435 |
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| 2009 |
Orun O, Rasmussen S, Gether U. Introducing tetraCys motifs at two different sites results in a functional dopamine transporter. Acta Biologica Hungarica. 60: 15-25. PMID 19378920 DOI: 10.1556/Abiol.60.2009.1.2 |
0.403 |
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| 2009 |
Meinild AK, Loo DD, Skovstrup S, Gether U, MacAulay N. Elucidating conformational changes in the gamma-aminobutyric acid transporter-1. The Journal of Biological Chemistry. 284: 16226-35. PMID 19363027 DOI: 10.1074/Jbc.M109.003137 |
0.315 |
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| 2009 |
Bhatia VK, Madsen KL, Bolinger P, Hedegârd P, Gether U, Stamou D. Screening the Sensing of Membrane Curvature by BAR domains on Single Liposome Arrays Biophysical Journal. 96: 570a. DOI: 10.1016/J.Bpj.2008.12.3735 |
0.357 |
|
| 2008 |
Binda F, Dipace C, Bowton E, Robertson SD, Lute BJ, Fog JU, Zhang M, Sen N, Colbran RJ, Gnegy ME, Gether U, Javitch JA, Erreger K, Galli A. Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Molecular Pharmacology. 74: 1101-8. PMID 18617632 DOI: 10.1124/Mol.108.048447 |
0.443 |
|
| 2008 |
Beuming T, Kniazeff J, Bergmann ML, Shi L, Gracia L, Raniszewska K, Newman AH, Javitch JA, Weinstein H, Gether U, Loland CJ. The binding sites for cocaine and dopamine in the dopamine transporter overlap. Nature Neuroscience. 11: 780-9. PMID 18568020 DOI: 10.1038/Nn.2146 |
0.389 |
|
| 2008 |
Madsen KL, Eriksen J, Milan-Lobo L, Han DS, Niv MY, Ammendrup-Johnsen I, Henriksen U, Bhatia VK, Stamou D, Sitte HH, McMahon HT, Weinstein H, Gether U. Membrane localization is critical for activation of the PICK1 BAR domain. Traffic (Copenhagen, Denmark). 9: 1327-43. PMID 18466293 DOI: 10.1111/J.1600-0854.2008.00761.X |
0.341 |
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| 2008 |
Klewe IV, Nielsen SM, Tarpø L, Urizar E, Dipace C, Javitch JA, Gether U, Egebjerg J, Christensen KV. Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling. Neuropharmacology. 54: 1215-22. PMID 18455202 DOI: 10.1016/J.Neuropharm.2008.03.015 |
0.354 |
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| 2008 |
Kniazeff J, Shi L, Loland CJ, Javitch JA, Weinstein H, Gether U. An intracellular interaction network regulates conformational transitions in the dopamine transporter. The Journal of Biological Chemistry. 283: 17691-701. PMID 18426798 DOI: 10.1074/Jbc.M800475200 |
0.401 |
|
| 2008 |
Bartholomäus I, Milan-Lobo L, Nicke A, Dutertre S, Hastrup H, Jha A, Gether U, Sitte HH, Betz H, Eulenburg V. Glycine transporter dimers: Evidence for occurrence in the plasma membrane Journal of Biological Chemistry. 283: 10978-10991. PMID 18252709 DOI: 10.1074/Jbc.M800622200 |
0.357 |
|
| 2008 |
Bassan M, Liu H, Madsen KL, Armsen W, Zhou J, Desilva T, Chen W, Paradise A, Brasch MA, Staudinger J, Gether U, Irwin N, Rosenberg PA. Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1. The European Journal of Neuroscience. 27: 66-82. PMID 18184314 DOI: 10.1111/J.1460-9568.2007.05986.X |
0.353 |
|
| 2008 |
Loland CJ, Desai RI, Zou MF, Cao J, Grundt P, Gerstbrein K, Sitte HH, Newman AH, Katz JL, Gether U. Relationship between conformational changes in the dopamine transporter and cocaine-like subjective effects of uptake inhibitors. Molecular Pharmacology. 73: 813-23. PMID 17978168 DOI: 10.1124/Mol.107.039800 |
0.381 |
|
| 2007 |
Adkins EM, Samuvel DJ, Fog JU, Eriksen J, Jayanthi LD, Vaegter CB, Ramamoorthy S, Gether U. Membrane mobility and microdomain association of the dopamine transporter studied with fluorescence correlation spectroscopy and fluorescence recovery after photobleaching. Biochemistry. 46: 10484-97. PMID 17711354 DOI: 10.1021/Bi700429Z |
0.423 |
|
| 2007 |
Plenge P, Gether U, Rasmussen SG. Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites. European Journal of Pharmacology. 567: 1-9. PMID 17499240 DOI: 10.1016/J.Ejphar.2007.03.055 |
0.308 |
|
| 2006 |
Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U. Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Neuron. 51: 417-29. PMID 16908408 DOI: 10.1016/J.Neuron.2006.06.028 |
0.445 |
|
| 2006 |
Gether U, Andersen PH, Larsson OM, Schousboe A. Neurotransmitter transporters: molecular function of important drug targets. Trends in Pharmacological Sciences. 27: 375-83. PMID 16762425 DOI: 10.1016/J.Tips.2006.05.003 |
0.403 |
|
| 2006 |
Jayanthi LD, Annamalai B, Samuvel DJ, Gether U, Ramamoorthy S. Phosphorylation of the norepinephrine transporter at threonine 258 and serine 259 is linked to protein kinase C-mediated transporter internalization. The Journal of Biological Chemistry. 281: 23326-40. PMID 16740633 DOI: 10.1074/Jbc.M601156200 |
0.338 |
|
| 2006 |
Nørgaard-Nielsen K, Gether U. Zn2+ modulation of neurotransmitter transporters. Handbook of Experimental Pharmacology. 175: 1-22. PMID 16722228 DOI: 10.1007/3-540-29784-7_1 |
0.402 |
|
| 2006 |
Kahlig KM, Lute BJ, Wei Y, Loland CJ, Gether U, Javitch JA, Galli A. Regulation of dopamine transporter trafficking by intracellular amphetamine. Molecular Pharmacology. 70: 542-8. PMID 16684900 DOI: 10.1124/Mol.106.023952 |
0.455 |
|
| 2006 |
Martinat C, Bacci JJ, Leete T, Kim J, Vanti WB, Newman AH, Cha JH, Gether U, Wang H, Abeliovich A. Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. Proceedings of the National Academy of Sciences of the United States of America. 103: 2874-9. PMID 16477036 DOI: 10.1073/Pnas.0511153103 |
0.337 |
|
| 2005 |
Cha JH, Zou MF, Adkins EM, Rasmussen SG, Loland CJ, Schoenenberger B, Gether U, Newman AH. Rhodamine-labeled 2beta-carbomethoxy-3beta-(3,4-dichlorophenyl)tropane analogues as high-affinity fluorescent probes for the dopamine transporter. Journal of Medicinal Chemistry. 48: 7513-6. PMID 16302792 DOI: 10.1021/Jm050431Y |
0.345 |
|
| 2005 |
Kniazeff J, Loland CJ, Goldberg N, Quick M, Das S, Sitte HH, Javitch JA, Gether U. Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8. Neuropharmacology. 49: 715-23. PMID 16129457 DOI: 10.1016/J.Neuropharm.2005.07.003 |
0.415 |
|
| 2005 |
Madsen KL, Beuming T, Niv MY, Chang CW, Dev KK, Weinstein H, Gether U. Molecular determinants for the complex binding specificity of the PDZ domain in PICK1. The Journal of Biological Chemistry. 280: 20539-48. PMID 15774468 DOI: 10.1074/Jbc.M500577200 |
0.36 |
|
| 2005 |
Henriksen U, Gether U, Litman T. Effect of Walker A mutation (K86M) on oligomerization and surface targeting of the multidrug resistance transporter ABCG2. Journal of Cell Science. 118: 1417-26. PMID 15769853 DOI: 10.1242/Jcs.01729 |
0.378 |
|
| 2005 |
Rasmussen SG, Gether U. Purification and fluorescent labeling of the human serotonin transporter. Biochemistry. 44: 3494-505. PMID 15736959 DOI: 10.1021/Bi048022B |
0.355 |
|
| 2004 |
Meinild AK, Sitte HH, Gether U. Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter. The Journal of Biological Chemistry. 279: 49671-9. PMID 15358780 DOI: 10.1074/Jbc.M407660200 |
0.419 |
|
| 2004 |
Bjerggaard C, Fog JU, Hastrup H, Madsen K, Loland CJ, Javitch JA, Gether U. Surface targeting of the dopamine transporter involves discrete epitopes in the distal C terminus but does not require canonical PDZ domain interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7024-36. PMID 15295038 DOI: 10.1523/Jneurosci.1863-04.2004 |
0.382 |
|
| 2004 |
Loland CJ, Grånäs C, Javitch JA, Gether U. Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding. The Journal of Biological Chemistry. 279: 3228-38. PMID 14597628 DOI: 10.1074/Jbc.M304755200 |
0.403 |
|
| 2003 |
Loland CJ, Norgaard-Nielsen K, Gether U. Probing dopamine transporter structure and function by Zn2+-site engineering. European Journal of Pharmacology. 479: 187-97. PMID 14612149 DOI: 10.1016/J.Ejphar.2003.08.068 |
0.422 |
|
| 2003 |
Rasmussen SG, Adkins EM, Carroll FI, Maresch MJ, Gether U. Structural and functional probing of the biogenic amine transporters by fluorescence spectroscopy. European Journal of Pharmacology. 479: 13-22. PMID 14612134 DOI: 10.1016/J.Ejphar.2003.08.053 |
0.414 |
|
| 2003 |
Norregaard L, Loland CJ, Gether U. Evidence for distinct sodium-, dopamine-, and cocaine-dependent conformational changes in transmembrane segments 7 and 8 of the dopamine transporter. The Journal of Biological Chemistry. 278: 30587-96. PMID 12773538 DOI: 10.1074/Jbc.M303854200 |
0.444 |
|
| 2003 |
MacAulay N, Meinild AK, Zeuthen T, Gether U. Residues in the extracellular loop 4 are critical for maintaining the conformational equilibrium of the gamma-aminobutyric acid transporter-1. The Journal of Biological Chemistry. 278: 28771-7. PMID 12764157 DOI: 10.1074/Jbc.M213023200 |
0.35 |
|
| 2003 |
Granas C, Ferrer J, Loland CJ, Javitch JA, Gether U. N-terminal truncation of the dopamine transporter abolishes phorbol ester- and substance P receptor-stimulated phosphorylation without impairing transporter internalization. The Journal of Biological Chemistry. 278: 4990-5000. PMID 12464618 DOI: 10.1074/Jbc.M205058200 |
0.401 |
|
| 2002 |
Gether U, Asmar F, Meinild AK, Rasmussen SG. Structural basis for activation of G-protein-coupled receptors. Pharmacology & Toxicology. 91: 304-12. PMID 12688373 DOI: 10.1034/J.1600-0773.2002.910607.X |
0.306 |
|
| 2002 |
MacAulay N, Zeuthen T, Gether U. Conformational basis for the Li(+)-induced leak current in the rat gamma-aminobutyric acid (GABA) transporter-1. The Journal of Physiology. 544: 447-58. PMID 12381817 DOI: 10.1113/Jphysiol.2002.022897 |
0.324 |
|
| 2002 |
Norgaard-Nielsen K, Norregaard L, Hastrup H, Javitch JA, Gether U. Zn(2+) site engineering at the oligomeric interface of the dopamine transporter. Febs Letters. 524: 87-91. PMID 12135746 DOI: 10.1016/S0014-5793(02)03008-9 |
0.444 |
|
| 2002 |
Scholze P, Nørregaard L, Singer EA, Freissmuth M, Gether U, Sitte HH. The role of zinc ions in reverse transport mediated by monoamine transporters. The Journal of Biological Chemistry. 277: 21505-13. PMID 11940571 DOI: 10.1074/Jbc.M112265200 |
0.384 |
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| 2002 |
Loland CJ, Norregaard L, Litman T, Gether U. Generation of an activating Zn(2+) switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle. Proceedings of the National Academy of Sciences of the United States of America. 99: 1683-1688. PMID 11818545 DOI: 10.1073/Pnas.032386299 |
0.438 |
|
| 2001 |
Ballesteros JA, Jensen AD, Liapakis G, Rasmussen SG, Shi L, Gether U, Javitch JA. Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. The Journal of Biological Chemistry. 276: 29171-7. PMID 11375997 DOI: 10.1074/Jbc.M103747200 |
0.317 |
|
| 2001 |
Gether U, Norregaard L, Loland CJ. Delineating structure-function relationships in the dopamine transporter from natural and engineered Zn2+ binding sites Life Sciences. 68: 2187-2198. PMID 11358327 DOI: 10.1016/S0024-3205(01)01005-0 |
0.411 |
|
| 2001 |
Rasmussen SGF, Carroll FI, Maresch MJ, Jensen AD, Tate CG, Gether U. Biophysical Characterization of the Cocaine Binding Pocket in the Serotonin Transporter Using a Fluorescent Cocaine Analogue as a Molecular Reporter Journal of Biological Chemistry. 276: 4717-4723. PMID 11062247 DOI: 10.1074/Jbc.M008067200 |
0.355 |
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| 2000 |
Norregaard L, Visiers I, Loland CJ, Ballesteros J, Weinstein H, Gether U. Structural Probing of a Microdomain in the Dopamine Transporter by Engineering of Artificial Zn2+ Binding Sites† Biochemistry. 39: 15836-15846. PMID 11123909 DOI: 10.1021/Bi0018335 |
0.402 |
|
| 2000 |
Gether U. Uncovering Molecular Mechanisms Involved in Activation of G Protein-Coupled Receptors Endocrine Reviews. 21: 90-113. PMID 10696571 DOI: 10.1210/Edrv.21.1.0390 |
0.323 |
|
| 1999 |
Loland CJ, Norregaard L, Gether U. Defining Proximity Relationships in the Tertiary Structure of the Dopamine Transporter IDENTIFICATION OF A CONSERVED GLUTAMIC ACID AS A THIRD COORDINATE IN THE ENDOGENOUS Zn2+-BINDING SITE Journal of Biological Chemistry. 274: 36928-36934. PMID 10601246 DOI: 10.1074/Jbc.274.52.36928 |
0.387 |
|
| 1999 |
Rasmussen SG, Jensen AD, Liapakis G, Ghanouni P, Javitch JA, Gether U. Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6. Molecular Pharmacology. 56: 175-84. PMID 10385699 DOI: 10.1124/Mol.56.1.175 |
0.329 |
|
| 1999 |
Seifert R, Wenzel-Seifert K, Gether U, Lam VT, Kobilka BK. Examining the efficiency of receptor/G-protein coupling with a cleavable beta2-adrenoceptor-gsalpha fusion protein. European Journal of Biochemistry / Febs. 260: 661-6. PMID 10102993 DOI: 10.1046/J.1432-1327.1999.00161.X |
0.347 |
|
| 1999 |
Kobilka B, Gether U, Seifert R, Lin S, Ghanouni P. Characterization of ligand-induced conformational states in the beta 2 adrenergic receptor. Journal of Receptor and Signal Transduction Research. 19: 293-300. PMID 10071765 DOI: 10.3109/10799899909036652 |
0.324 |
|
| 1998 |
Norregaard L, Frederiksen D, Nielsen EØ, Gether U. Delineation of an endogenous zinc‐binding site in the human dopamine transporter The Embo Journal. 17: 4266-4273. PMID 9687495 DOI: 10.1093/Emboj/17.15.4266 |
0.454 |
|
| 1998 |
Seifert R, Wenzel-Seifert K, Lee TW, Gether U, Sanders-Bush E, Kobilka BK. Different effects of Gsalpha splice variants on beta2-adrenoreceptor-mediated signaling. The beta2-adrenoreceptor coupled to the long splice variant of Gsalpha has properties of a constitutively active receptor. The Journal of Biological Chemistry. 273: 5109-16. PMID 9478963 DOI: 10.1074/Jbc.273.9.5109 |
0.337 |
|
| 1998 |
Kobilka BK, Gether U. Examination of ligand-induced conformational changes in the beta 2-adrenergic receptor by fluorescence spectroscopy. Advances in Pharmacology (San Diego, Calif.). 42: 470-3. PMID 9327941 DOI: 10.1016/S1054-3589(08)60790-5 |
0.317 |
|
| 1997 |
Gether U, Lin S, Ghanouni P, Ballesteros JA, Weinstein H, Kobilka BK. Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor. The Embo Journal. 16: 6737-47. PMID 9362488 DOI: 10.1093/Emboj/16.22.6737 |
0.34 |
|
| 1995 |
Gether U, Lin S, Kobilka BK. Fluorescent labeling of purified beta 2 adrenergic receptor. Evidence for ligand-specific conformational changes. The Journal of Biological Chemistry. 270: 28268-75. PMID 7499324 DOI: 10.1074/Jbc.270.47.28268 |
0.319 |
|
| 1990 |
Fuhlendorff J, Gether U, Aakerlund L, Langeland-Johansen N, Thogersen H, Melberg SG, Olsen UB, Thastrup O, Schwartz TW. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist Proceedings of the National Academy of Sciences of the United States of America. 87: 182-186. PMID 2153286 DOI: 10.1073/Pnas.87.1.182 |
0.305 |
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