David A. Brown - Related publications

Affiliations: 
Neuroscience, Physiology & Pharmacology University College, University of London, London, England, United Kingdom 
Area:
Regulation of ion channels that control neural excitability
Website:
http://www.ucl.ac.uk/npp/people/brown-david
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Yousuf A, Wu X, Bony AR, Sadeghi M, Huang YH, Craik DJ, Adams DJ. ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (Ca 2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABA receptor activation. Journal of Neurochemistry. PMID 34738241 DOI: 10.1111/jnc.15535   
2021 Cho HY, Chuang TH, Wu SN. The Effectiveness in Activating M-Type K Current Produced by Solifenacin ([(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate): Independent of Its Antimuscarinic Action. International Journal of Molecular Sciences. 22. PMID 34830281 DOI: 10.3390/ijms222212399   
2021 Wang N, Dries E, Fowler ED, Harmer SC, Hancox JC, Cannell MB. Inducing I and phase 1 repolarization of the cardiac action potential with a Kv4.3/KChIP2.1 bicistronic transgene. Journal of Molecular and Cellular Cardiology. 164: 29-41. PMID 34823101 DOI: 10.1016/j.yjmcc.2021.11.004   
2021 Alijevic O, Peng Z, Kellenberger S. Changes in H, K, and Ca Concentrations, as Observed in Seizures, Induce Action Potential Signaling in Cortical Neurons by a Mechanism That Depends Partially on Acid-Sensing Ion Channels. Frontiers in Cellular Neuroscience. 15: 732869. PMID 34720879 DOI: 10.3389/fncel.2021.732869   
2021 Yuasa M, Kojima A, Mi X, Ding WG, Omatsu-Kanbe M, Kitagawa H, Matsuura H. Characterization and functional role of rapid- and slow-activating delayed rectifier K currents in atrioventricular node cells of guinea pigs. Pflugers Archiv : European Journal of Physiology. PMID 34704178 DOI: 10.1007/s00424-021-02617-z   
2021 Pergel E, Veres I, Csigi GI, Czirják G. Translocation of TMEM175 Lysosomal Potassium Channel to the Plasma Membrane by Dynasore Compounds. International Journal of Molecular Sciences. 22. PMID 34638858 DOI: 10.3390/ijms221910515   
2021 Fuchs E, Messerer DAC, Karpel-Massler G, Fauler M, Zimmer T, Jungwirth B, Föhr KJ. Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10. Frontiers in Pharmacology. 12: 737637. PMID 34744721 DOI: 10.3389/fphar.2021.737637   
2021 Gong Y, Yang L, Tang J, Zheng J, Witman N, Jakob P, Tan Y, Liu M, Chen Y, Wang H, Fu W, Wang W. Yohimbine Directly Induces Cardiotoxicity on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cardiovascular Toxicology. PMID 34817810 DOI: 10.1007/s12012-021-09709-3   
2021 Contreras GF, Saavedra J, Navarro-Quezada N, Mellado G, Gonzalez C, Neely A. Direct inhibition of Ca2.3 by Gem is dynamin dependent and does not require a direct alfa/beta interaction. Biochemical and Biophysical Research Communications. 586: 107-113. PMID 34837834 DOI: 10.1016/j.bbrc.2021.11.052   
2021 Lin RJ, Yen YK, Lee CH, Hsieh SL, Chang YC, Juan YS, Long CY, Shen KP, Wu BN. Eugenosedin-A improves obesity-related hyperglycemia by regulating ATP-sensitive K channels and insulin secretion in pancreatic β cells. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 145: 112447. PMID 34808553 DOI: 10.1016/j.biopha.2021.112447   
2021 Sun J, Pan S, Karey E, Chen YJ, Pinkerton KE, Wilson CG, Chen CY. Secondhand Smoke Decreased Excitability and Altered Action Potential Characteristics of Cardiac Vagal Neurons in Mice. Frontiers in Physiology. 12: 727000. PMID 34630146 DOI: 10.3389/fphys.2021.727000   
2021 Hwang S, Kim JH, Jo SH. Inhibitory effect of the selective serotonin reuptake inhibitor paroxetine on human Kv1.3 channels. European Journal of Pharmacology. 174567. PMID 34662565 DOI: 10.1016/j.ejphar.2021.174567   
2021 Liu Q, Sun J, Zhang L, Xu Y, Wu B, Cao J. The Agonist of Inward Rectifier Potassium Channel (I) Attenuates Rat Reperfusion Arrhythmias Linked to CaMKII Signaling. International Heart Journal. 62: 1348-1357. PMID 34853227 DOI: 10.1536/ihj.21-379   
2021 Angelini M, Pezhouman A, Savalli N, Chang MG, Steccanella F, Scranton K, Calmettes G, Ottolia M, Pantazis A, Karagueuzian HS, Weiss JN, Olcese R. Suppression of ventricular arrhythmias by targeting late L-type Ca2+ current. The Journal of General Physiology. 153. PMID 34698805 DOI: 10.1085/jgp.202012584   
2021 Naseem MU, Tajti G, Gaspar A, Szanto TG, Borrego J, Panyi G. Optimization of Expression System for High-Level Production of Margatoxin. Frontiers in Pharmacology. 12: 733610. PMID 34658872 DOI: 10.3389/fphar.2021.733610   
2021 Lari E, Buck LT. Exposure to low temperature prepares the turtle brain to withstand anoxic environments during overwintering. The Journal of Experimental Biology. 224. PMID 34498078 DOI: 10.1242/jeb.242793   
2021 Perissinotti PP, Martínez-Hernández E, He Y, Koob MD, Piedras-Rentería ES. Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin. Frontiers in Neuroscience. 15: 718464. PMID 34566565 DOI: 10.3389/fnins.2021.718464   
2021 Choi S, Seo H, Lee K, Shin DH, Wu MJ, Wu W, Huang X, Zhang J, Hong C, Jun JY. Hyperpolarization-activated cyclic nucleotide-gated channels working as pacemaker channels in colonic interstitial cells of Cajal. Journal of Cellular and Molecular Medicine. PMID 34845842 DOI: 10.1111/jcmm.17087   
2021 Phan HTL, Kim HJ, Jo S, Kim WK, Namkung W, Nam JH. Anti-Inflammatory Effect of Licochalcone A via Regulation of ORAI1 and K Channels in T-Lymphocytes. International Journal of Molecular Sciences. 22. PMID 34639190 DOI: 10.3390/ijms221910847   
2021 Zhang Y, Qian Z, Jiang D, Sun Y, Gao S, Jiang X, Wang H, Tao J. Neuromedin B receptor stimulation of Cav3.2 T-type Ca channels in primary sensory neurons mediates peripheral pain hypersensitivity. Theranostics. 11: 9342-9357. PMID 34646374 DOI: 10.7150/thno.62255   
2021 Yin X, Yang GF, Niu DB, Chen J, Liao M, Cao HQ, Sheng CW. Identification and pharmacological characterization of histamine-gated chloride channels in the fall armyworm, Spodoptera frugiperda. Insect Biochemistry and Molecular Biology. 103698. PMID 34848284 DOI: 10.1016/j.ibmb.2021.103698   
2021 Varma D, Almeida JFQ, DeSantiago J, Blatter LA, Banach K. Inositol 1,4,5-trisphosphate receptor - reactive oxygen signaling domain regulates excitation-contraction coupling in atrial myocytes. Journal of Molecular and Cellular Cardiology. 163: 147-155. PMID 34755642 DOI: 10.1016/j.yjmcc.2021.10.006   
2021 Zhang S, Tang L, Xu F, Hui Y, Lu H, Liu X. TRPV1 Receptor-Mediated Hypoglycemic Mechanism of Capsaicin in Streptozotocin-Induced Diabetic Rats. Frontiers in Nutrition. 8: 750355. PMID 34692753 DOI: 10.3389/fnut.2021.750355   
2021 Li X, Zeng Q, Wang S, Li M, Chen X, Huang Y, Chen B, Zhou M, Lai Y, Guo C, Zhao S, Zhang H, Yang N. CRAC Channel Controls the Differentiation of Pathogenic B Cells in Lupus Nephritis. Frontiers in Immunology. 12: 779560. PMID 34745151 DOI: 10.3389/fimmu.2021.779560   
2021 Ördög B, Teplenin A, De Coster T, Bart CI, Dekker SO, Zhang J, Ypey DL, de Vries AAF, Pijnappels DA. The Effects of Repetitive Use and Pathological Remodeling on Channelrhodopsin Function in Cardiomyocytes. Frontiers in Physiology. 12: 710020. PMID 34539432 DOI: 10.3389/fphys.2021.710020   
2021 Sanford JA, Wang Y, Hansen JR, Gritsenko MA, Weitz KK, Sagendorf TJ, Tognon CE, Petyuk VA, Qian WJ, Liu T, Druker BJ, Rodland KD, Piehowski PD. Evaluation of Differential Peptide Loading on Tandem Mass Tag-Based Proteomic and Phosphoproteomic Data Quality. Journal of the American Society For Mass Spectrometry. PMID 34813325 DOI: 10.1021/jasms.1c00169   
2021 Funazaki S, Yoshida M, Yamada H, Kakei M, Kawakami M, Nagashima S, Hara K, Dezaki K. A novel mechanism of imeglimin-mediated insulin secretion via the cADPR-TRP channel pathway. Journal of Diabetes Investigation. PMID 34523242 DOI: 10.1111/jdi.13669   
2021 Zheng L, Lindsay A, McSweeney K, Aplin J, Forbes K, Smith S, Tunwell R, Mackrill JJ. Ryanodine Receptor Calcium Release Channels in Trophoblasts and their Role in Cell Migration. Biochimica Et Biophysica Acta. Molecular Cell Research. 119139. PMID 34624436 DOI: 10.1016/j.bbamcr.2021.119139   
2021 Jeong S, Rhee JS, Lee JH. Snapin Specifically Up-Regulates Ca1.3 Ca Channel Variant with a Long Carboxyl Terminus. International Journal of Molecular Sciences. 22. PMID 34681928 DOI: 10.3390/ijms222011268   
2021 Dalaman U, Özdoğan H, Sircan AK, Şengül SA, Yaraş N. Sulfur Dioxide Derivative Prevents the Prolongation of Action Potential During the Isoproterenol-Induced Hypertrophy of Rat Cardiomyocytes. Anais Da Academia Brasileira De Ciencias. 93: e20201664. PMID 34550202 DOI: 10.1590/0001-3765202120201664   
2021 Cai W, Liu SS, Li BM, Zhang XH. Presynaptic HCN channels constrain GABAergic synaptic transmission in pyramidal cells of the medial prefrontal cortex. Biology Open. PMID 34709375 DOI: 10.1242/bio.058840   
2021 Matasic DS, Holland N, Gautam M, Gibbons DD, Kusama N, Harding AMS, Shah VS, Snyder PM, Benson CJ. Paradoxical Potentiation of Acid-Sensing Ion Channel 3 (ASIC3) by Amiloride Multiple Mechanisms and Sites Within the Channel. Frontiers in Physiology. 12: 750696. PMID 34721074 DOI: 10.3389/fphys.2021.750696   
2021 Lewis AH, Grandl J. Piezo1 ion channels inherently function as independent mechanotransducers. Elife. 10. PMID 34711306 DOI: 10.7554/eLife.70988   
2021 Lukacs P, Pesti K, Földi MC, Zboray K, Toth AV, Papp G, Mike A. An Advanced Automated Patch Clamp Protocol Design to Investigate Drug-Ion Channel Binding Dynamics. Frontiers in Pharmacology. 12: 738260. PMID 34658875 DOI: 10.3389/fphar.2021.738260   
2021 Al-Moubarak E, Shiels HA, Zhang Y, Du C, Hanington O, Harmer SC, Dempsey CE, Hancox JC. Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. Cellular and Molecular Life Sciences : Cmls. PMID 34727194 DOI: 10.1007/s00018-021-03967-8   
2021 Al-Moubarak E, Shiels HA, Zhang Y, Du C, Hanington O, Harmer SC, Dempsey CE, Hancox JC. Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant. Cellular and Molecular Life Sciences : Cmls. PMID 34727194 DOI: 10.1007/s00018-021-03967-8   
2021 Dvorak NM, Tapia CM, Baumgartner TJ, Singh J, Laezza F, Singh AK. Pharmacological Inhibition of Wee1 Kinase Selectively Modulates the Voltage-Gated Na Channel 1.2 Macromolecular Complex. Cells. 10. PMID 34831326 DOI: 10.3390/cells10113103   
2021 Völkner C, Holzner LJ, Day PM, Ashok AD, Vries J, Bölter B, Kunz HH. Two plastid POLLUX ion channel-like proteins are required for stress-triggered stromal Ca2+ release. Plant Physiology. PMID 34618095 DOI: 10.1093/plphys/kiab424   
2021 Ozacmak VH, Arrieta AR, Thorington GU, Hessinger DA. -Acetyl Neuraminic Acid (NANA) Activates L-Type Calcium Channels on Isolated Tentacle Supporting Cells of the Sea Anemone (). The Biological Bulletin. 241: 196-207. PMID 34706210 DOI: 10.1086/715844   
2021 Li T, Chen J, Zeng Z. Pathophysiological role of calcium channels and transporters in the multiple myeloma. Cell Communication and Signaling : Ccs. 19: 99. PMID 34579758 DOI: 10.1186/s12964-021-00781-4   
2021 Yang L, Deng N, He J, Xia G, Yang Y, Zhao Y, Huo Z, Guo C. gene knockdown inhibits transient outward potassium current ion channel remodeling in hypertrophic ventricular myocyte. Open Life Sciences. 16: 1010-1021. PMID 34632071 DOI: 10.1515/biol-2021-0107   
2021 Gebremendhin D, Lindemer B, Weihrauch D, Harder DR, Lohr NL. Electromagnetic energy (670 nm) stimulates vasodilation through activation of the large conductance potassium channel (BKCa). Plos One. 16: e0257896. PMID 34610026 DOI: 10.1371/journal.pone.0257896   
2021 Gadotti VM, Huang S, Zamponi GW. The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels. Molecular Brain. 14: 166. PMID 34775970 DOI: 10.1186/s13041-021-00876-6   
2021 Burkhoff D, Rich S, Pollesello P, Papp Z. Levosimendan-induced venodilation is mediated by opening of potassium channels. Esc Heart Failure. PMID 34716759 DOI: 10.1002/ehf2.13669   
2021 Liu M, Ge N, Zhang J, Yang M, Yang F, Krawczyk J, Ward D, McInerney V, O'Brien T, Shen S, Prendiville T. Derivation and characterization of two human induced pluripotent stem cell lines (NUIGi004-A) and (NUIGi012-A) from two patients with LQT2 disease. Stem Cell Research. 56: 102555. PMID 34628246 DOI: 10.1016/j.scr.2021.102555   
2021 Jia T, Wang X, Tang Y, Yu W, Li C, Cui S, Zhu J, Meng W, Wang C, Wang Q. Sacubitril Ameliorates Cardiac Fibrosis Through Inhibiting TRPM7 Channel. Frontiers in Cell and Developmental Biology. 9: 760035. PMID 34778271 DOI: 10.3389/fcell.2021.760035   
2021 Sánchez JC, Valencia-Vásquez A, García AM. Role of TRPV4 Channel in Human White Adipocytes Metabolic Activity. Endocrinology and Metabolism (Seoul, Korea). PMID 34648704 DOI: 10.3803/EnM.2021.1167   
2021 Hu F, Song X, Long D. Transient receptor potential ankyrin 1 and calcium: Interactions and association with disease (Review). Experimental and Therapeutic Medicine. 22: 1462. PMID 34737802 DOI: 10.3892/etm.2021.10897   
2021 Setterberg IE, Le C, Frisk M, Li J, Louch WE. The Physiology and Pathophysiology of T-Tubules in the Heart. Frontiers in Physiology. 12: 718404. PMID 34566684 DOI: 10.3389/fphys.2021.718404   
2021 Hung YC, Kuo YH, Hsieh PW, Hsieh TY, Kuo JR, Wang SJ. Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca Channel Suppression: A Possible Neuroprotective Mechanism. International Journal of Molecular Sciences. 22. PMID 34768876 DOI: 10.3390/ijms222111447