| Year |
Citation |
Score |
| 2023 |
Pai C, McIntosh BA, Knutsen RH, Levin MD, Tsang KM, Kozel BA, Heuckeroth RO. Loss of Baz1b in mice causes perinatal lethality, growth failure, and variable multi-system outcomes. Developmental Biology. 505: 42-57. PMID 37827362 DOI: 10.1016/j.ydbio.2023.09.007 |
0.312 |
|
| 2021 |
Gao T, Wright-Jin EC, Sengupta R, Anderson JB, Heuckeroth RO. Cell-autonomous retinoic acid receptor signaling has stage-specific effects on mouse enteric nervous system. Jci Insight. PMID 33848271 DOI: 10.1172/jci.insight.145854 |
0.702 |
|
| 2021 |
Wright CM, Schneider S, Smith-Edwards KM, Mafra F, Leembruggen AJL, Gonzalez MV, Kothakapa DR, Anderson JB, Maguire BA, Gao T, Missall TA, Howard MJ, Bornstein JC, Davis BM, Heuckeroth RO. scRNA-sequencing reveals new enteric nervous system roles for GDNF, NRTN, and TBX3. Cellular and Molecular Gastroenterology and Hepatology. PMID 33444816 DOI: 10.1016/j.jcmgh.2020.12.014 |
0.319 |
|
| 2020 |
Smith-Edwards KM, Edwards BS, Wright CM, Schneider S, Meerschaert KA, Ejoh LL, Najjar SA, Howard MJ, Albers KM, Heuckeroth RO, Davis BM. Sympathetic input to multiple cell types in mouse and human colon produces region-specific responses. Gastroenterology. PMID 32980343 DOI: 10.1053/j.gastro.2020.09.030 |
0.326 |
|
| 2020 |
Soret R, Schneider S, Bernas G, Christophers B, Souchkova O, Charrier B, Righini-Grunder F, Aspirot A, Landry M, Kembel SW, Faure C, Heuckeroth RO, Pilon N. Glial Cell Derived Neurotrophic Factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease. Gastroenterology. PMID 32687927 DOI: 10.1053/J.Gastro.2020.07.018 |
0.372 |
|
| 2020 |
Baumgarten HD, Wright CM, Rossidis AC, Lawrence KM, Kim AG, Mejaddam AY, McGovern PE, Orr MN, Coons BE, Butt Z, Li H, Hwang G, Radu A, Brown LJ, Rubenstein RC, ... ... Heuckeroth RO, et al. The EXTra-uterine Environment for Neonatal Development supports normal intestinal maturation and development. Cellular and Molecular Gastroenterology and Hepatology. PMID 32474164 DOI: 10.1016/J.Jcmgh.2020.05.006 |
0.334 |
|
| 2020 |
Wright CM, Garifallou JP, Schneider S, Mentch HL, Kothakapa DR, Maguire BA, Heuckeroth RO. Dlx1/2 mice have abnormal enteric nervous system function. Jci Insight. PMID 32017713 DOI: 10.1172/Jci.Insight.131494 |
0.446 |
|
| 2019 |
Schill EM, Wright CM, Jamil A, LaCombe JM, Roper RJ, Heuckeroth RO. Down syndrome mouse models have an abnormal enteric nervous system. Jci Insight. 5. PMID 30998504 DOI: 10.1172/Jci.Insight.124510 |
0.409 |
|
| 2019 |
Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, ... Heuckeroth RO, et al. The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell. PMID 30930166 DOI: 10.1016/J.Devcel.2019.03.001 |
0.32 |
|
| 2018 |
Schneider S, Wright CM, Heuckeroth RO. Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function. Annual Review of Physiology. PMID 30379617 DOI: 10.1146/Annurev-Physiol-021317-121515 |
0.417 |
|
| 2018 |
White JP, Xiong S, Malvin NP, Khoury-Hanold W, Heuckeroth RO, Stappenbeck TS, Diamond MS. Intestinal Dysmotility Syndromes following Systemic Infection by Flaviviruses. Cell. PMID 30293866 DOI: 10.1016/J.Cell.2018.08.069 |
0.411 |
|
| 2018 |
López SH, Avetisyan M, Wright CM, Mesbah K, Kelly RG, Moon AM, Heuckeroth RO. Loss of Tbx3 in murine neural crest reduces enteric glia and causes cleft palate, but does not influence heart development or bowel transit. Developmental Biology. PMID 30292786 DOI: 10.1016/J.Ydbio.2018.09.017 |
0.442 |
|
| 2018 |
Avetisyan M, Rood JE, Huerta Lopez S, Sengupta R, Wright-Jin E, Dougherty JD, Behrens EM, Heuckeroth RO. Muscularis macrophage development in the absence of an enteric nervous system. Proceedings of the National Academy of Sciences of the United States of America. PMID 29666241 DOI: 10.1073/Pnas.1802490115 |
0.719 |
|
| 2018 |
Heuckeroth RO. Hirschsprung disease - integrating basic science and clinical medicine to improve outcomes. Nature Reviews. Gastroenterology & Hepatology. PMID 29300049 DOI: 10.1038/Nrgastro.2017.149 |
0.378 |
|
| 2017 |
Abernathy DG, Kim WK, McCoy MJ, Lake AM, Ouwenga R, Lee SW, Xing X, Li D, Lee HJ, Heuckeroth RO, Dougherty JD, Wang T, Yoo AS. MicroRNAs Induce a Permissive Chromatin Environment that Enables Neuronal Subtype-Specific Reprogramming of Adult Human Fibroblasts. Cell Stem Cell. 21: 332-348.e9. PMID 28886366 DOI: 10.1016/J.Stem.2017.08.002 |
0.379 |
|
| 2016 |
Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schafer KH, Metzger M, Hotta R, Young HM, Andrews PW, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, ... ... Heuckeroth RO, et al. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology. PMID 27059883 DOI: 10.1016/J.Ydbio.2016.04.001 |
0.308 |
|
| 2016 |
Heuckeroth RO, Schäfer KH. Gene-environment interactions and the enteric nervous system: Neural plasticity and Hirschsprung disease prevention. Developmental Biology. PMID 26997034 DOI: 10.1016/J.Ydbio.2016.03.017 |
0.474 |
|
| 2016 |
Heuckeroth RO. Regeneration: Stem cells make the bowel nervous. Nature. 531: 44-5. PMID 26863191 DOI: 10.1038/Nature16877 |
0.414 |
|
| 2015 |
Merrick Schill E, Lake JI, Tusheva OA, Nagy N, Bery SK, Foster L, Avetisyan M, Johnson SL, Stenson WF, Goldstein AM, Heuckeroth RO. Ibuprofen slows migration and inhibits bowel colonization by enteric nervous system precursors in zebrafish, chick and mouse. Developmental Biology. PMID 26586201 DOI: 10.1016/J.Ydbio.2015.09.023 |
0.437 |
|
| 2015 |
Heuckeroth RO. Hirschsprung's disease, Down syndrome, and missing heritability: too much collagen slows migration. The Journal of Clinical Investigation. 125: 4323-6. PMID 26571392 DOI: 10.1172/Jci85003 |
0.365 |
|
| 2015 |
Lake JI, Avetisyan M, Zimmermann AG, Heuckeroth RO. Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton. Developmental Biology. PMID 26546974 DOI: 10.1016/J.Ydbio.2015.11.004 |
0.421 |
|
| 2015 |
Avetisyan M, Wang H, Schill EM, Bery S, Grider JR, Hassell JA, Stappenbeck T, Heuckeroth RO. Hepatocyte Growth Factor and MET Support Mouse Enteric Nervous System Development, the Peristaltic Response, and Intestinal Epithelial Proliferation in Response to Injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11543-58. PMID 26290232 DOI: 10.1523/Jneurosci.5267-14.2015 |
0.487 |
|
| 2015 |
Avetisyan M, Schill EM, Heuckeroth RO. Building a second brain in the bowel. The Journal of Clinical Investigation. 125: 899-907. PMID 25664848 DOI: 10.1172/Jci76307 |
0.369 |
|
| 2015 |
Schrenk S, Schuster A, Klotz M, Schleser F, Lake J, Heuckeroth RO, Kim YJ, Laschke MW, Menger MD, Schäfer KH. Vascular and neural stem cells in the gut: do they need each other? Histochemistry and Cell Biology. 143: 397-410. PMID 25371326 DOI: 10.1007/S00418-014-1288-9 |
0.369 |
|
| 2013 |
Lake JI, Tusheva OA, Graham BL, Heuckeroth RO. Hirschsprung-like disease is exacerbated by reduced de novo GMP synthesis. The Journal of Clinical Investigation. 123: 4875-87. PMID 24216510 DOI: 10.1172/Jci69781 |
0.413 |
|
| 2013 |
Fu M, Landreville S, Agapova OA, Wiley LA, Shoykhet M, Harbour JW, Heuckeroth RO. Retinoblastoma protein prevents enteric nervous system defects and intestinal pseudo-obstruction. The Journal of Clinical Investigation. 123: 5152-64. PMID 24177421 DOI: 10.1172/Jci67653 |
0.507 |
|
| 2013 |
Wright-Jin EC, Grider JR, Duester G, Heuckeroth RO. Retinaldehyde dehydrogenase enzymes regulate colon enteric nervous system structure and function. Developmental Biology. 381: 28-37. PMID 23806210 DOI: 10.1016/J.Ydbio.2013.06.021 |
0.734 |
|
| 2013 |
Lake JI, Heuckeroth RO. Enteric nervous system development: migration, differentiation, and disease. American Journal of Physiology. Gastrointestinal and Liver Physiology. 305: G1-24. PMID 23639815 DOI: 10.1152/Ajpgi.00452.2012 |
0.431 |
|
| 2012 |
Hitch MC, Leinicke JA, Wakeman D, Guo J, Erwin CR, Rowland KJ, Merrick EC, Heuckeroth RO, Warner BW. Ret heterozygous mice have enhanced intestinal adaptation after massive small bowel resection. American Journal of Physiology. Gastrointestinal and Liver Physiology. 302: G1143-50. PMID 22421622 DOI: 10.1152/Ajpgi.00296.2011 |
0.379 |
|
| 2011 |
Viader A, Wright-Jin EC, Vohra BP, Heuckeroth RO, Milbrandt J. Differential regional and subtype-specific vulnerability of enteric neurons to mitochondrial dysfunction. Plos One. 6: e27727. PMID 22110743 DOI: 10.1371/Journal.Pone.0027727 |
0.713 |
|
| 2010 |
Jain S, Knoten A, Hoshi M, Wang H, Vohra B, Heuckeroth RO, Milbrandt J. Organotypic specificity of key RET adaptor-docking sites in the pathogenesis of neurocristopathies and renal malformations in mice. The Journal of Clinical Investigation. 120: 778-90. PMID 20160347 DOI: 10.1172/Jci41619 |
0.366 |
|
| 2010 |
Fu M, Sato Y, Lyons-Warren A, Zhang B, Kane MA, Napoli JL, Heuckeroth RO. Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation. Development (Cambridge, England). 137: 631-40. PMID 20110328 DOI: 10.1242/Dev.040550 |
0.392 |
|
| 2010 |
Wang H, Hughes I, Planer W, Parsadanian A, Grider JR, Vohra BP, Keller-Peck C, Heuckeroth RO. The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 1523-38. PMID 20107080 DOI: 10.1523/Jneurosci.3861-09.2010 |
0.501 |
|
| 2010 |
Heuckeroth RO. Autonomic and Enteric Nervous System: Apoptosis and Trophic Support During Development Encyclopedia of Neuroscience. 791-798. DOI: 10.1016/B978-008045046-9.00488-5 |
0.308 |
|
| 2009 |
Zhang B, Chang J, Fu M, Huang J, Kashyap R, Salavaggione E, Jain S, Kulkarni S, Shashikant K, Deardorff MA, Uzielli ML, Dorsett D, Beebe DC, Jay PY, Heuckeroth RO, et al. Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies. Plos One. 4: e5232. PMID 19412548 DOI: 10.1371/Journal.Pone.0005232 |
0.406 |
|
| 2008 |
Sato Y, Heuckeroth RO. Retinoic acid regulates murine enteric nervous system precursor proliferation, enhances neuronal precursor differentiation, and reduces neurite growth in vitro. Developmental Biology. 320: 185-98. PMID 18561907 DOI: 10.1016/J.Ydbio.2008.05.524 |
0.494 |
|
| 2007 |
Vohra BP, Fu M, Heuckeroth RO. Protein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9458-68. PMID 17728459 DOI: 10.1523/Jneurosci.0870-07.2007 |
0.38 |
|
| 2007 |
Zhang B, Jain S, Song H, Fu M, Heuckeroth RO, Erlich JM, Jay PY, Milbrandt J. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome. Development (Cambridge, England). 134: 3191-201. PMID 17652350 DOI: 10.1242/Dev.005884 |
0.43 |
|
| 2007 |
Wang H, Zhang Y, Heuckeroth RO. PAI-1 deficiency reduces liver fibrosis after bile duct ligation in mice through activation of tPA. Febs Letters. 581: 3098-104. PMID 17561000 DOI: 10.1016/J.Febslet.2007.05.049 |
0.302 |
|
| 2007 |
Wang H, Zhang Y, Heuckeroth RO. Tissue-type plasminogen activator deficiency exacerbates cholestatic liver injury in mice. Hepatology (Baltimore, Md.). 45: 1527-37. PMID 17538930 DOI: 10.1002/Hep.21613 |
0.327 |
|
| 2007 |
Vohra BP, Planer W, Armon J, Fu M, Jain S, Heuckeroth RO. Reduced endothelin converting enzyme-1 and endothelin-3 mRNA in the developing bowel of male mice may increase expressivity and penetrance of Hirschsprung disease-like distal intestinal aganglionosis. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 236: 106-17. PMID 17131407 DOI: 10.1002/Dvdy.21028 |
0.373 |
|
| 2006 |
Fu M, Vohra BP, Wind D, Heuckeroth RO. BMP signaling regulates murine enteric nervous system precursor migration, neurite fasciculation, and patterning via altered Ncam1 polysialic acid addition. Developmental Biology. 299: 137-50. PMID 16952347 DOI: 10.1016/J.Ydbio.2006.07.016 |
0.432 |
|
| 2006 |
Vohra BP, Tsuji K, Nagashimada M, Uesaka T, Wind D, Fu M, Armon J, Enomoto H, Heuckeroth RO. Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis. Developmental Biology. 298: 259-71. PMID 16904662 DOI: 10.1016/J.Ydbio.2006.06.033 |
0.359 |
|
| 2005 |
Wang H, Vohra BP, Zhang Y, Heuckeroth RO. Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice. Hepatology (Baltimore, Md.). 42: 1099-108. PMID 16250054 DOI: 10.1002/Hep.20903 |
0.307 |
|
| 2005 |
Srinivasan S, Anitha M, Mwangi S, Heuckeroth RO. Enteric neuroblasts require the phosphatidylinositol 3-kinase/Akt/Forkhead pathway for GDNF-stimulated survival. Molecular and Cellular Neurosciences. 29: 107-19. PMID 15866051 DOI: 10.1016/J.Mcn.2005.02.005 |
0.315 |
|
| 2005 |
Skinner MA, Kalyanaraman S, Safford SD, Heuckeroth RO, Tourtellotte W, Goyeau D, Goodfellow P, Milbrandt JD, Freemerman A. A human yeast artificial chromosome containing the multiple endocrine neoplasia type 2B Ret mutation does not induce medullary thyroid carcinoma but does support the growth of kidneys and partially rescues enteric nervous system development in Ret-deficient mice. The American Journal of Pathology. 166: 265-74. PMID 15632018 DOI: 10.1016/S0002-9440(10)62250-X |
0.353 |
|
| 2004 |
Enomoto H, Hughes I, Golden J, Baloh RH, Yonemura S, Heuckeroth RO, Johnson EM, Milbrandt J. GFRalpha1 expression in cells lacking RET is dispensable for organogenesis and nerve regeneration. Neuron. 44: 623-36. PMID 15541311 DOI: 10.1016/J.Neuron.2004.10.032 |
0.386 |
|
| 2004 |
Jain S, Naughton CK, Yang M, Strickland A, Vij K, Encinas M, Golden J, Gupta A, Heuckeroth R, Johnson EM, Milbrandt J. Mice expressing a dominant-negative Ret mutation phenocopy human Hirschsprung disease and delineate a direct role of Ret in spermatogenesis. Development (Cambridge, England). 131: 5503-13. PMID 15469971 DOI: 10.1242/Dev.01421 |
0.434 |
|
| 2004 |
Wanigasekara Y, Airaksinen MS, Heuckeroth RO, Milbrandt J, Keast JR. Neurturin signalling via GFRα2 is essential for innervation of glandular but not muscle targets of sacral parasympathetic ganglion neurons Molecular and Cellular Neuroscience. 25: 288-300. PMID 15019945 DOI: 10.1016/J.Mcn.2003.10.019 |
0.436 |
|
| 2003 |
Heuckeroth RO. Finding your way to the end: a tale of GDNF and endothelin-3. Neuron. 40: 871-3. PMID 14659083 DOI: 10.1016/S0896-6273(03)00763-3 |
0.331 |
|
| 2003 |
Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J, Pflugfelder SC. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Investigative Ophthalmology & Visual Science. 44: 4223-9. PMID 14507865 DOI: 10.1167/Iovs.02-1319 |
0.364 |
|
| 2003 |
Gianino S, Grider JR, Cresswell J, Enomoto H, Heuckeroth RO. GDNF availability determines enteric neuron number by controlling precursor proliferation. Development (Cambridge, England). 130: 2187-98. PMID 12668632 DOI: 10.1242/Dev.00433 |
0.498 |
|
| 2002 |
Honma Y, Araki T, Gianino S, Bruce A, Heuckeroth R, Johnson E, Milbrandt J. Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons. Neuron. 35: 267-82. PMID 12160745 DOI: 10.1016/S0896-6273(02)00774-2 |
0.333 |
|
| 2000 |
Enomoto H, Heuckeroth RO, Golden JP, Johnson EM, Milbrandt J. Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin. Development (Cambridge, England). 127: 4877-89. PMID 11044402 |
0.36 |
|
| 1999 |
Mazziotti MV, Willis LK, Heuckeroth RO, LaRegina MC, Swanson PE, Overbeek PA, Perlmutter DH. Anomalous development of the hepatobiliary system in the Inv mouse. Hepatology (Baltimore, Md.). 30: 372-8. PMID 10421642 DOI: 10.1002/Hep.510300223 |
0.339 |
|
| 1999 |
Heuckeroth RO, Enomoto H, Grider JR, Golden JP, Hanke JA, Jackman A, Molliver DC, Bardgett ME, Snider WD, Johnson EM, Milbrandt J. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 22: 253-63. PMID 10069332 DOI: 10.1016/S0896-6273(00)81087-9 |
0.432 |
|
| 1998 |
Enomoto H, Araki T, Jackman A, Heuckeroth RO, Snider WD, Johnson EM, Milbrandt J. GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys. Neuron. 21: 317-24. PMID 9728913 DOI: 10.1016/S0896-6273(00)80541-3 |
0.376 |
|
| 1998 |
Heuckeroth RO, Lampe PA, Johnson EM, Milbrandt J. Neurturin and GDNF promote proliferation and survival of enteric neuron and glial progenitors in vitro. Developmental Biology. 200: 116-29. PMID 9698461 DOI: 10.1006/Dbio.1998.8955 |
0.434 |
|
| 1998 |
Milbrandt J, de Sauvage FJ, Fahrner TJ, Baloh RH, Leitner ML, Tansey MG, Lampe PA, Heuckeroth RO, Kotzbauer PT, Simburger KS, Golden JP, Davies JA, Vejsada R, Kato AC, Hynes M, et al. Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron. 20: 245-53. PMID 9491986 DOI: 10.1016/S0896-6273(00)80453-5 |
0.395 |
|
| 1997 |
Heuckeroth RO, Kotzbauer P, Copeland NG, Gilbert DJ, Jenkins NA, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J. Neurturin, a novel neurotrophic factor, is localized to mouse chromosome 17 and human chromosome 19p13.3. Genomics. 44: 137-40. PMID 9286710 DOI: 10.1006/Geno.1997.4846 |
0.352 |
|
| 1997 |
Creedon DJ, Tansey MG, Baloh RH, Osborne PA, Lampe PA, Fahrner TJ, Heuckeroth RO, Milbrandt J, Johnson EM. Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 94: 7018-23. PMID 9192684 DOI: 10.1073/Pnas.94.13.7018 |
0.412 |
|
| 1997 |
Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J. TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron. 18: 793-802. PMID 9182803 DOI: 10.1016/S0896-6273(00)80318-9 |
0.367 |
|
| 1996 |
Kotzbauer PT, Lampe PA, Heuckeroth RO, Golden JP, Creedon DJ, Johnson EM, Milbrandt J. Neurturin, a relative of glial-cell-line-derived neurotrophic factor Nature. 384: 467-470. PMID 8945474 DOI: 10.1038/384467A0 |
0.426 |
|
| 1990 |
Johnson DR, Cox AD, Solski PA, Devadas B, Adams SP, Leimgruber RM, Heuckeroth RO, Buss JE, Gordon JI. Functional analysis of protein N-myristoylation: metabolic labeling studies using three oxygen-substituted analogs of myristic acid and cultured mammalian cells provide evidence for protein-sequence-specific incorporation and analog-specific redistribution. Proceedings of the National Academy of Sciences of the United States of America. 87: 8511-5. PMID 2236060 DOI: 10.1073/Pnas.87.21.8511 |
0.303 |
|
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