| Year |
Citation |
Score |
| 2023 |
Sun G, Leclerc GJ, Chahar S, Barredo JC. AAMPK associates with chromatin and phosphorylates the TAF-1 subunit of the transcription initiation complex to regulate histone gene expression in ALL cells. Molecular Cancer Research : McR. PMID 37682252 DOI: 10.1158/1541-7786.MCR-23-0502 |
0.346 |
|
| 2021 |
Sun G, Shvab A, Leclerc GJ, Li B, Beckedorff F, Shiekhattar R, Barredo JC. Protein Kinase D-Dependent Downregulation Of Immediate Early Genes Through Class IIa Histone Deacetylases In Acute Lymphoblastic Leukemia. Molecular Cancer Research : McR. PMID 33980612 DOI: 10.1158/1541-7786.MCR-20-0808 |
0.5 |
|
| 2019 |
Shah D, Reichbach Douglas J, Ashy J, Suhrheinrich G, Ziga ED, Pillai AB, Barredo JC, Alperstein W. A Single Institution Experience of Bortezomib for Gvhd in a Pediatric HSCT Population Blood. 134: 5680-5680. DOI: 10.1182/Blood-2019-125884 |
0.312 |
|
| 2019 |
Shvab A, Sun G, Li B, Beckedorff F, Leclerc GJ, Shiekhattar R, Barredo JC. Abstract 1289: AICAR inhibits protein kinase D1 activity leading to epigenetic downregulation of immediate early genes via the NF-kB pathway in acute lymphoblastic leukemia Cancer Research. 79: 1289-1289. DOI: 10.1158/1538-7445.Am2019-1289 |
0.651 |
|
| 2018 |
Trucco M, Barredo JC, Goldberg J, Leclerc GM, Hale GA, Gill J, Setty B, Smith T, Lush R, Lee JK, Reed DR. A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, PEG-asparaginase, and doxorubicin. Pediatric Blood & Cancer. e27224. PMID 29856514 DOI: 10.1002/pbc.27224 |
0.474 |
|
| 2018 |
Zheng S, Leclerc GM, Li B, Swords RT, Barredo JC. Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia. Oncotarget. 9: 5529-5544. PMID 29464016 DOI: 10.18632/Oncotarget.23797 |
0.631 |
|
| 2018 |
Sun GC, Shvab AC, Li BC, Beckedorff FC, Leclerc GJ, Shiekhattar R, Barredo JC. Acadesine Elicits a Rapid Epigenetic Reprograming of Immediate Early Genes through the Protein Kinase D1 Pathway in Acute Lymphoblastic Leukemia Cells Undergoing Energy/Metabolic Stress Blood. 132: 1321-1321. DOI: 10.1182/Blood-2018-99-112678 |
0.574 |
|
| 2017 |
Barredo JC, Hastings C, Lu X, Devidas FM, Chen Y, Armstrong D, Winick N, Wood BL, Yanofsky R, Loh M, Gastier-Foster JM, Jorstad DT, Marcus R, Ritchey K, Carrol WL, et al. Isolated late testicular relapse of B-cell acute lymphoblastic leukemia treated with intensive systemic chemotherapy and response-based testicular radiation: A Children's Oncology Group study. Pediatric Blood & Cancer. PMID 29286562 DOI: 10.1002/Pbc.26928 |
0.329 |
|
| 2017 |
Trucco M, Barredo J, Goldberg J, Hale G, Gill J, Setty B, Smith T, Lee J, Reed D. Abstract CT145: A phase I window, dose escalating and safety trial of Metformin in combination with induction chemotherapy (VPLD)in relapsed/refractory acute lymphoblastic leukemia: NCT01324180 Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Ct145 |
0.464 |
|
| 2016 |
Leclerc GM, Zheng S, Leclerc GJ, DeSalvo J, Swords RT, Barredo JC. The NEDD8-activating enzyme inhibitor pevonedistat activates the eIF2α and mTOR pathways inducing UPR-mediated cell death in acute lymphoblastic leukemia. Leukemia Research. 50: 1-10. PMID 27626202 DOI: 10.1016/j.leukres.2016.09.007 |
0.624 |
|
| 2016 |
Liu H, Kurtoglu M, León-Annicchiarico CL, Munoz-Pinedo C, Barredo J, Leclerc G, Merchan J, Liu X, Lampidis TJ. Combining 2-deoxy-D-glucose with fenofibrate leads to tumor cell death mediated by simultaneous induction of energy and ER stress. Oncotarget. PMID 27183907 DOI: 10.18632/Oncotarget.9263 |
0.508 |
|
| 2016 |
Campuzano-Zuluaga G, Ortiz D, Peng JH, Francis Ikpatt O, Fan YS, Barredo JC, Vega F, Chapman JR. Primary Mediastinal Large B-Cell Lymphoma With Translocations Involving BCL6 and MYC (Double-Hit Lymphoma). American Journal of Clinical Pathology. PMID 27124935 DOI: 10.1093/Ajcp/Aqw018 |
0.371 |
|
| 2016 |
Barredo JC, Goldberg JM, Hale G, Gill JB, Setty B, Smith T, Lee JK, Reed DR. A phase I window, dose escalating and safety trial of metformin in combination with induction chemotherapy in relapsed refractory acute lymphoblastic leukemia: Metformin with induction chemotherapy of vincristine, dexamethasone, doxorubicin, and PEG-asparaginase (VPLD). Journal of Clinical Oncology. 34: 10530-10530. DOI: 10.1200/Jco.2016.34.15_Suppl.10530 |
0.428 |
|
| 2015 |
Leclerc GJ, DeSalvo J, Du J, Gao N, Leclerc GM, Lehrman MA, Lampidis TJ, Barredo JC. Mcl-1 downregulation leads to the heightened sensitivity exhibited by BCR-ABL positive ALL to induction of energy and ER-stress. Leukemia Research. PMID 26346348 DOI: 10.1016/J.Leukres.2015.08.007 |
0.517 |
|
| 2015 |
Leclerc GM, Zheng S, Leclerc GJ, DeSalvo J, Swords RT, Barredo JC. The NEDD8 Activating Enzyme Inhibitor Pevonedistat Induces ER Stress/UPR-Mediated Cell Death and Rebalances Homeostasis of Pro- and Anti-Apoptotic Proteins in Favor of Cell Death in Acute Lymphoblastic Leukemia Cells Blood. 126: 1327-1327. DOI: 10.1182/Blood.V126.23.1327.1327 |
0.728 |
|
| 2014 |
Leclerc GJ, DeSalvo J, Leclerc GM, Lampidis TJ, Barredo JC. BCR-ABL+ Bp-ALL Exhibits Heightened Sensitivity to Simultaneous Induction of Energy and ER Stress Via Downregulation of Mcl-1 Expression Blood. 124: 916-916. DOI: 10.1182/Blood.V124.21.916.916 |
0.585 |
|
| 2014 |
Goldberg JM, Glade-Bender J, Sulis ML, Gardner RA, Pollard JA, Aquino V, Winick NJ, Bostrom BC, Fu C, Hutchinson RJ, Manley TJ, Mody R, Oesterheld J, Thomson B, Park JR, ... ... Barredo JC, et al. A Phase I Dose Finding Study of Panobinostat in Children with Hematologic Malignancies: Initial Report of TACL Study T2009-012 in Children with Acute Leukemia Blood. 124: 3705-3705. DOI: 10.1182/Blood.V124.21.3705.3705 |
0.305 |
|
| 2013 |
Leclerc GM, Leclerc GJ, Kuznetsov JN, DeSalvo J, Barredo JC. Metformin induces apoptosis through AMPK-dependent inhibition of UPR signaling in ALL lymphoblasts. Plos One. 8: e74420. PMID 24009772 DOI: 10.1371/Journal.Pone.0074420 |
0.817 |
|
| 2013 |
Xi H, Barredo JC, Merchan JR, Lampidis TJ. Endoplasmic reticulum stress induced by 2-deoxyglucose but not glucose starvation activates AMPK through CaMKKβ leading to autophagy. Biochemical Pharmacology. 85: 1463-77. PMID 23500541 DOI: 10.1016/J.Bcp.2013.02.037 |
0.536 |
|
| 2013 |
Leclerc GM, Zheng S, Swords RT, Leclerc GJ, Barredo JC. The NEDD8 Conjugation Pathway Inhibitor MLN4924 Activates AMPK and Induces The ER Stress/UPR-Mediated Cell Death Pathway In Acute Lymphoblastic Leukemia Blood. 122: 1285-1285. DOI: 10.1182/Blood.V122.21.1285.1285 |
0.743 |
|
| 2012 |
DeSalvo J, Kuznetsov JN, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC. Inhibition of Akt potentiates 2-DG-induced apoptosis via downregulation of UPR in acute lymphoblastic leukemia. Molecular Cancer Research : McR. 10: 969-78. PMID 22692960 DOI: 10.1158/1541-7786.Mcr-12-0125 |
0.819 |
|
| 2012 |
Leclerc GJ, Du J, DeSalvo J, Leclerc GM, Barredo JC. The BCR-ABL Fusion Protein Sensitizes Acute Lymphoblastic Leukemia to Apoptotic Death Induced by the Dual Glycolytic and Glycosylation Inhibitor 2-Deoxy-D-Glucose. Blood. 120: 2439-2439. DOI: 10.1182/Blood.V120.21.2439.2439 |
0.679 |
|
| 2012 |
Kuznetsov JN, DeSalvo J, Du J, Leclerc GM, Leclerc GJ, Lampidis TJ, Barredo JC. Abstract 4991: Akt and AMPK modulate UPR activity and determine ER stress-induced cell death in response to 2-DG in ALL Cancer Research. 72: 4991-4991. DOI: 10.1158/1538-7445.Am2012-4991 |
0.815 |
|
| 2012 |
Leclerc GM, Leclerc GJ, Kuznetsov JN, Barredo JC. Abstract 2736: PIM2 is up-regulated in response to metformin-induced cell death triggered by ER stress/UPR in ALL lymphoblasts Cancer Research. 72: 2736-2736. DOI: 10.1158/1538-7445.Am2012-2736 |
0.821 |
|
| 2011 |
Wang WC, Ware RE, Miller ST, Iyer RV, Casella JF, Minniti CP, Rana S, Thornburg CD, Rogers ZR, Kalpatthi RV, Barredo JC, Brown RC, Sarnaik SA, Howard TH, Wynn LW, et al. Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre, randomised, controlled trial (BABY HUG). Lancet. 377: 1663-72. PMID 21571150 DOI: 10.1016/S0140-6736(11)60355-3 |
0.356 |
|
| 2011 |
Kuznetsov JN, Leclerc GJ, Leclerc GM, Barredo JC. AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia. Molecular Cancer Therapeutics. 10: 437-47. PMID 21262957 DOI: 10.1158/1535-7163.Mct-10-0777 |
0.812 |
|
| 2011 |
Leclerc GM, Leclerc GJ, Kuznetsov JN, Barredo JC. PIM2 Upregulation Leads to Physiological Buffering of Metformin-Induced Cell Death Mediated by ER Stress/UPR in Acute Lymphoblastic Leukemia, Blood. 118: 3496-3496. DOI: 10.1182/Blood.V118.21.3496.3496 |
0.82 |
|
| 2011 |
Leclerc GM, Leclerc GJ, Kuznetsov J, Barredo JC. Abstract 605: A novel role for AMPK as a molecular switch regulating the activation of Akt and RAS signaling in acute lymphoblastic leukemia Cancer Research. 71: 605-605. DOI: 10.1158/1538-7445.Am2011-605 |
0.793 |
|
| 2010 |
Leclerc GM, Leclerc GJ, Fu G, Barredo JC. AMPK-induced activation of Akt by AICAR is mediated by IGF-1R dependent and independent mechanisms in acute lymphoblastic leukemia. Journal of Molecular Signaling. 5: 15. PMID 20863384 DOI: 10.1186/1750-2187-5-15 |
0.546 |
|
| 2010 |
Leclerc GJ, Sanderson C, Hunger S, Devidas M, Barredo JC. Folylpolyglutamate synthetase gene transcription is regulated by a multiprotein complex that binds the TEL-AML1 fusion in acute lymphoblastic leukemia. Leukemia Research. 34: 1601-9. PMID 20538338 DOI: 10.1016/J.Leukres.2010.05.012 |
0.345 |
|
| 2010 |
Leclerc GJ, Mou C, Leclerc GM, Mian AM, Barredo JC. Histone deacetylase inhibitors induce FPGS mRNA expression and intracellular accumulation of long-chain methotrexate polyglutamates in childhood acute lymphoblastic leukemia: implications for combination therapy. Leukemia. 24: 552-62. PMID 20072153 DOI: 10.1182/Blood.V112.11.2923.2923 |
0.472 |
|
| 2010 |
Du J, DeSalvo J, Muranen A, Moraes CT, Barredo JC. Inhibition of Akt Increases the Sensitivity of Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG) Blood. 116: 3254-3254. DOI: 10.1182/Blood.V116.21.3254.3254 |
0.688 |
|
| 2010 |
Leclerc GM, Kuznetsov JN, Barredo JC. Abstract 5089: AMPK activationvs.inhibition induces apoptosis in acute lymphoblastic leukemia cells by differentially altering PI3K/Akt/mTOR or RAS/cRAF/MEK/Erk signaling Cancer Research. 70: 5089-5089. DOI: 10.1158/1538-7445.Am10-5089 |
0.8 |
|
| 2009 |
Du J, DeSalvo J, Barredo JC. Mechanisms of Sensitivity of B-Precursor, T-Lineage and BCR/ABL Positive Acute Lymphoblastic Leukemia (ALL) to the Glycolytic Inhibitor 2-Deoxy-D-Glucose (2-DG). Blood. 114: 3081-3081. DOI: 10.1182/Blood.V114.22.3081.3081 |
0.683 |
|
| 2008 |
Eapen M, Zhang MJ, Devidas M, Raetz E, Barredo JC, Ritchey AK, Godder K, Grupp S, Lewis VA, Malloy K, Carroll WL, Davies SM, Camitta BM. Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: A collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research Leukemia. 22: 281-286. PMID 18033318 DOI: 10.1038/Sj.Leu.2405037 |
0.315 |
|
| 2007 |
Sengupta TK, Leclerc GM, Hsieh-Kinser TT, Leclerc GJ, Singh I, Barredo JC. Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Molecular Cancer. 6: 46. PMID 17623090 DOI: 10.1186/1476-4598-6-46 |
0.684 |
|
| 2007 |
Leclerc GJ, Barredo JC. Histone Deacetylase Inhibitor Induces FPGS mRNA Expression in Childhood B-Precursor and T Acute Lymphoblastic Leukemia: Implication of Combination Therapy with Methotrexate To Enhance Cytotoxicity. Blood. 110: 864-864. DOI: 10.1182/Blood.V110.11.864.864 |
0.47 |
|
| 2006 |
Eapen M, Zhang M, Raetz E, Devidas M, Carroll WL, Ritchey AK, Barredo JC, Godder K, Grupp SA, Lewis VA, Davies S, Camitta B. Outcomes after HLA-Matched Sibling Transplants or Chemotherapy in Children with Acute Lymphoblastic Leukemia in a Second Remission after an Isolated Central Nervous System Relapse. Blood. 108: 49-49. DOI: 10.1182/Blood.V108.11.49.49 |
0.309 |
|
| 2005 |
Barredo JC, Kinser T, Leclerc GJ. TEL/AML1 and E2A/PBX1 Tranlsocations Lead to Altered Folylpoly-γ-Glutamate Synthetase (FPGS) Expression in ALL. Blood. 106: 539-539. DOI: 10.1182/blood.v106.11.539.539 |
0.32 |
|
| 2004 |
Barredo JC, Altman-Hamandzic S, Leclerc GJ. Differences in Folylpoly-γ-Glutamate Synthetase (FPGS) Expression in Childhood ALL Result from Cell Lineage of Origin and Presence of Non-Random Translocations. Blood. 104: 2087-2087. DOI: 10.1182/blood.v104.11.2087.2087 |
0.348 |
|
| 1994 |
Barredo JC, Synold TW, Laver J, Relling MV, Pui CH, Priest DG, Evans WE. Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia Blood. 84: 564-569. PMID 7517720 |
0.313 |
|
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