Ron Mandel - Publications

Affiliations: 
Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Parkinson, aging

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Gombash SE, Manfredsson FP, Mandel RJ, Collier TJ, Fischer DL, Kemp CJ, Kuhn NM, Wohlgenant SL, Fleming SM, Sortwell CE. Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways. Gene Therapy. 21: 682-93. PMID 24807806 DOI: 10.1038/gt.2014.42  0.44
2012 Manfredsson FP, Bloom DC, Mandel RJ. Regulated protein expression for in vivo gene therapy for neurological disorders: progress, strategies, and issues. Neurobiology of Disease. 48: 212-21. PMID 22426391 DOI: 10.1016/j.nbd.2012.03.001  0.44
2012 Gombash SE, Lipton JW, Collier TJ, Madhavan L, Steece-Collier K, Cole-Strauss A, Terpstra BT, Spieles-Engemann AL, Daley BF, Wohlgenant SL, Thompson VB, Manfredsson FP, Mandel RJ, Sortwell CE. Striatal pleiotrophin overexpression provides functional and morphological neuroprotection in the 6-hydroxydopamine model. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 544-54. PMID 22008908 DOI: 10.1038/mt.2011.216  0.44
2011 Tebbenkamp AT, Green C, Xu G, Denovan-Wright EM, Rising AC, Fromholt SE, Brown HH, Swing D, Mandel RJ, Tessarollo L, Borchelt DR. Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller proteolytic derivative. Human Molecular Genetics. 20: 2770-82. PMID 21515588 DOI: 10.1093/hmg/ddr176  0.44
2011 Manfredsson FP, Mandel RJ. The development of flexible lentiviral vectors for gene transfer in the CNS. Experimental Neurology. 229: 201-6. PMID 21459087 DOI: 10.1016/j.expneurol.2011.03.013  0.44
2011 Mandel RJ, Lowenstein PR, Byrne BJ. AAV6-mediated gene silencing fALS short. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 231-3. PMID 21289637 DOI: 10.1038/mt.2010.306  0.44
2011 Rising AC, Xu J, Carlson A, Napoli VV, Denovan-Wright EM, Mandel RJ. Longitudinal behavioral, cross-sectional transcriptional and histopathological characterization of a knock-in mouse model of Huntington's disease with 140 CAG repeats. Experimental Neurology. 228: 173-82. PMID 21192926 DOI: 10.1016/j.expneurol.2010.12.017  0.44
2010 Gorbatyuk OS, Li S, Nguyen FN, Manfredsson FP, Kondrikova G, Sullivan LF, Meyers C, Chen W, Mandel RJ, Muzyczka N. α-Synuclein expression in rat substantia nigra suppresses phospholipase D2 toxicity and nigral neurodegeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1758-68. PMID 20664530 DOI: 10.1038/mt.2010.137  0.44
2010 Gorbatyuk OS, Li S, Nash K, Gorbatyuk M, Lewin AS, Sullivan LF, Mandel RJ, Chen W, Meyers C, Manfredsson FP, Muzyczka N. In vivo RNAi-mediated alpha-synuclein silencing induces nigrostriatal degeneration. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 1450-7. PMID 20551914 DOI: 10.1038/mt.2010.115  0.44
2010 Mandel RJ. CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease. Current Opinion in Molecular Therapeutics. 12: 240-7. PMID 20373268  0.44
2010 Manfredsson FP, Mandel RJ. Development of gene therapy for neurological disorders. Discovery Medicine. 9: 204-11. PMID 20350486  0.44
2010 Dodiya HB, Bjorklund T, Stansell J, Mandel RJ, Kirik D, Kordower JH. Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 579-87. PMID 19773746 DOI: 10.1038/mt.2009.216  0.44
2009 Manfredsson FP, Okun MS, Mandel RJ. Gene therapy for neurological disorders: challenges and future prospects for the use of growth factors for the treatment of Parkinson's disease. Current Gene Therapy. 9: 375-88. PMID 19860652 DOI: 10.2174/156652309789753400  0.44
2009 Manfredsson FP, Burger C, Rising AC, Zuobi-Hasona K, Sullivan LF, Lewin AS, Huang J, Piercefield E, Muzyczka N, Mandel RJ. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 1857-67. PMID 19707186 DOI: 10.1038/mt.2009.196  0.44
2009 Björklund T, Hall H, Breysse N, Soneson C, Carlsson T, Mandel RJ, Carta M, Kirik D. Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats. Journal of Neurochemistry. 111: 355-67. PMID 19686242 DOI: 10.1111/j.1471-4159.2009.06340.x  0.44
2009 Manfredsson FP, Tumer N, Erdos B, Landa T, Broxson CS, Sullivan LF, Rising AC, Foust KD, Zhang Y, Muzyczka N, Gorbatyuk OS, Scarpace PJ, Mandel RJ. Nigrostriatal rAAV-mediated GDNF overexpression induces robust weight loss in a rat model of age-related obesity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 980-91. PMID 19277011 DOI: 10.1038/mt.2009.45  0.44
2009 Manfredsson FP, Rising AC, Mandel RJ. AAV9: a potential blood-brain barrier buster. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 403-5. PMID 19247366 DOI: 10.1038/mt.2009.15  0.44
2009 Leriche L, Björklund T, Breysse N, Besret L, Grégoire MC, Carlsson T, Dollé F, Mandel RJ, Déglon N, Hantraye P, Kirik D. Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1544-53. PMID 19193901 DOI: 10.1523/JNEUROSCI.4491-08.2009  0.44
2009 Peden CS, Manfredsson FP, Reimsnider SK, Poirier AE, Burger C, Muzyczka N, Mandel RJ. Striatal readministration of rAAV vectors reveals an immune response against AAV2 capsids that can be circumvented. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 524-37. PMID 19142181 DOI: 10.1038/mt.2008.284  0.44
2008 Denovan-Wright EM, Attis M, Rodriguez-Lebron E, Mandel RJ. Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 mice. Journal of Neuroscience Research. 86: 1748-57. PMID 18293418 DOI: 10.1002/jnr.21636  0.44
2008 Burger C, Lopez MC, Baker HV, Mandel RJ, Muzyczka N. Genome-wide analysis of aging and learning-related genes in the hippocampal dentate gyrus. Neurobiology of Learning and Memory. 89: 379-96. PMID 18234529 DOI: 10.1016/j.nlm.2007.11.006  0.44
2008 Gorbatyuk OS, Li S, Sullivan LF, Chen W, Kondrikova G, Manfredsson FP, Mandel RJ, Muzyczka N. The phosphorylation state of Ser-129 in human alpha-synuclein determines neurodegeneration in a rat model of Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 763-8. PMID 18178617 DOI: 10.1073/pnas.0711053105  0.44
2008 Denovan-Wright EM, Rodriguez-Lebron E, Lewin AS, Mandel RJ. Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo. Neurobiology of Disease. 29: 446-55. PMID 18166484 DOI: 10.1016/j.nbd.2007.11.003  0.44
2008 Foust KD, Flotte TR, Reier PJ, Mandel RJ. Recombinant adeno-associated virus-mediated global anterograde delivery of glial cell line-derived neurotrophic factor to the spinal cord: comparison of rubrospinal and corticospinal tracts in the rat. Human Gene Therapy. 19: 71-82. PMID 18072858 DOI: 10.1089/hum.2007.104  0.44
2008 Foust KD, Poirier A, Pacak CA, Mandel RJ, Flotte TR. Neonatal intraperitoneal or intravenous injections of recombinant adeno-associated virus type 8 transduce dorsal root ganglia and lower motor neurons. Human Gene Therapy. 19: 61-70. PMID 18052722 DOI: 10.1089/hum.2007.093  0.44
2008 Mandel RJ, Burger C, Snyder RO. Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production. Experimental Neurology. 209: 58-71. PMID 17916354 DOI: 10.1016/j.expneurol.2007.08.008  0.44
2007 Lowenstein PR, Mandel RJ, Xiong WD, Kroeger K, Castro MG. Immune responses to adenovirus and adeno-associated vectors used for gene therapy of brain diseases: the role of immunological synapses in understanding the cell biology of neuroimmune interactions. Current Gene Therapy. 7: 347-60. PMID 17979681 DOI: 10.2174/156652307782151498  0.44
2007 Manfredsson FP, Burger C, Sullivan LF, Muzyczka N, Lewin AS, Mandel RJ. rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease. Experimental Neurology. 207: 289-301. PMID 17678648 DOI: 10.1016/j.expneurol.2007.06.019  0.44
2007 Johnson J, Paisán-Ruíz C, Lopez G, Crews C, Britton A, Malkani R, Evans EW, McInerney-Leo A, Jain S, Nussbaum RL, Foote KD, Mandel RJ, Crawley A, Reimsnider S, Fernandez HH, et al. Comprehensive screening of a North American Parkinson's disease cohort for LRRK2 mutation. Neuro-Degenerative Diseases. 4: 386-91. PMID 17622782 DOI: 10.1159/000105160  0.44
2007 Reimsnider S, Manfredsson FP, Muzyczka N, Mandel RJ. Time course of transgene expression after intrastriatal pseudotyped rAAV2/1, rAAV2/2, rAAV2/5, and rAAV2/8 transduction in the rat. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 1504-11. PMID 17565350 DOI: 10.1038/sj.mt.6300227  0.44
2007 Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D. Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain. Brain : a Journal of Neurology. 130: 799-815. PMID 17303591 DOI: 10.1093/brain/awl382  0.44
2007 Xiromerisiou G, Hadjigeorgiou GM, Eerola J, Fernandez HH, Tsimourtou V, Mandel R, Hellström O, Gwinn-Hardy K, Okun MS, Tienari PJ, Singleton AB. BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups. Neuroscience Letters. 415: 59-63. PMID 17229524 DOI: 10.1016/j.neulet.2006.12.038  0.44
2007 Burger C, López MC, Feller JA, Baker HV, Muzyczka N, Mandel RJ. Changes in transcription within the CA1 field of the hippocampus are associated with age-related spatial learning impairments. Neurobiology of Learning and Memory. 87: 21-41. PMID 16829144 DOI: 10.1016/j.nlm.2006.05.003  0.44
2006 Scholz S, Mandel RJ, Fernandez HH, Foote KD, Rodriguez RL, Barton E, Munson S, Singleton A, Okun MS. LRRK2 mutations in a clinic-based cohort of Parkinson's disease. European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies. 13: 1298-301. PMID 17116211 DOI: 10.1111/j.1468-1331.2006.01472.x  0.44
2006 Fung HC, Scholz S, Matarin M, Simón-Sánchez J, Hernandez D, Britton A, Gibbs JR, Langefeld C, Stiegert ML, Schymick J, Okun MS, Mandel RJ, Fernandez HH, Foote KD, Rodríguez RL, et al. Genome-wide genotyping in Parkinson's disease and neurologically normal controls: first stage analysis and public release of data. The Lancet. Neurology. 5: 911-6. PMID 17052657 DOI: 10.1016/S1474-4422(06)70578-6  0.44
2006 Kearns SM, Scheffler B, Goetz AK, Lin DD, Baker HD, Roper SN, Mandel RJ, Steindler DA. A method for a more complete in vitro Parkinson's model: slice culture bioassay for modeling maintenance and repair of the nigrostriatal circuit. Journal of Neuroscience Methods. 157: 1-9. PMID 16704878 DOI: 10.3201/eid1204.050756  0.44
2006 Mandel RJ, Manfredsson FP, Foust KD, Rising A, Reimsnider S, Nash K, Burger C. Recombinant adeno-associated viral vectors as therapeutic agents to treat neurological disorders. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 463-83. PMID 16412695 DOI: 10.1016/j.ymthe.2005.11.009  0.44
2006 Scholz SW, Xiromerisiou G, Fung HC, Eerola J, Hellström O, Papadimitriou A, Hadjigeorgiou GM, Tienari PJ, Fernandez HH, Mandel R, Okun MS, Gwinn-Hardy K, Singleton AB. The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations. Neuroscience Letters. 395: 227-9. PMID 16298483 DOI: 10.1016/j.neulet.2005.10.081  0.44
2006 Manfredsson FP, Lewin AS, Mandel RJ. RNA knockdown as a potential therapeutic strategy in Parkinson's disease. Gene Therapy. 13: 517-24. PMID 16267570 DOI: 10.1038/sj.gt.3302669  0.44
2006 Tümer N, Scarpace PJ, Dogan MD, Broxson CS, Matheny M, Yurek DM, Peden CS, Burger C, Muzyczka N, Mandel RJ. Hypothalamic rAAV-mediated GDNF gene delivery ameliorates age-related obesity. Neurobiology of Aging. 27: 459-70. PMID 15964099 DOI: 10.1016/j.neurobiolaging.2005.03.018  0.44
2005 Rodriguez-Lebron E, Denovan-Wright EM, Nash K, Lewin AS, Mandel RJ. Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 618-33. PMID 16019264 DOI: 10.1016/j.ymthe.2005.05.006  0.44
2005 Burger C, Nash K, Mandel RJ. Recombinant adeno-associated viral vectors in the nervous system. Human Gene Therapy. 16: 781-91. PMID 16000060 DOI: 10.1089/hum.2005.16.781  0.44
2005 Eslamboli A, Georgievska B, Ridley RM, Baker HF, Muzyczka N, Burger C, Mandel RJ, Annett L, Kirik D. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 769-77. PMID 15673656 DOI: 10.1523/JNEUROSCI.4421-04.2005  0.44
2005 Burger C, Nguyen FN, Deng J, Mandel RJ. Systemic mannitol-induced hyperosmolality amplifies rAAV2-mediated striatal transduction to a greater extent than local co-infusion. Molecular Therapy : the Journal of the American Society of Gene Therapy. 11: 327-31. PMID 15668145 DOI: 10.1016/j.ymthe.2004.08.031  0.44
2005 Carlsson T, Winkler C, Burger C, Muzyczka N, Mandel RJ, Cenci A, Björklund A, Kirik D. Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors. Brain : a Journal of Neurology. 128: 559-69. PMID 15659429 DOI: 10.1093/brain/awh374  0.44
2005 Irani BG, Xiang Z, Moore MC, Mandel RJ, Haskell-Luevano C. Voluntary exercise delays monogenetic obesity and overcomes reproductive dysfunction of the melanocortin-4 receptor knockout mouse. Biochemical and Biophysical Research Communications. 326: 638-44. PMID 15596147 DOI: 10.1016/j.bbrc.2004.11.084  0.44
2004 Rogaeva E, Johnson J, Lang AE, Gulick C, Gwinn-Hardy K, Kawarai T, Sato C, Morgan A, Werner J, Nussbaum R, Petit A, Okun MS, McInerney A, Mandel R, Groen JL, et al. Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease. Archives of Neurology. 61: 1898-904. PMID 15596610 DOI: 10.1001/archneur.61.12.1898  0.44
2004 Mandel RJ, Burger C. Clinical trials in neurological disorders using AAV vectors: promises and challenges. Current Opinion in Molecular Therapeutics. 6: 482-90. PMID 15537049  0.44
2004 Burger C, Gorbatyuk OS, Velardo MJ, Peden CS, Williams P, Zolotukhin S, Reier PJ, Mandel RJ, Muzyczka N. Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 302-17. PMID 15294177 DOI: 10.1016/j.ymthe.2004.05.024  0.44
2004 Peden CS, Burger C, Muzyczka N, Mandel RJ. Circulating anti-wild-type adeno-associated virus type 2 (AAV2) antibodies inhibit recombinant AAV2 (rAAV2)-mediated, but not rAAV5-mediated, gene transfer in the brain. Journal of Virology. 78: 6344-59. PMID 15163728 DOI: 10.1128/JVI.78.12.6344-6359.2004  0.44
2003 Arvidsson A, Kirik D, Lundberg C, Mandel RJ, Andsberg G, Kokaia Z, Lindvall O. Elevated GDNF levels following viral vector-mediated gene transfer can increase neuronal death after stroke in rats. Neurobiology of Disease. 14: 542-56. PMID 14678770 DOI: 10.1016/j.nbd.2003.08.002  0.44
2003 Eslamboli A, Cummings RM, Ridley RM, Baker HF, Muzyczka N, Burger C, Mandel RJ, Kirik D, Annett LE. Recombinant adeno-associated viral vector (rAAV) delivery of GDNF provides protection against 6-OHDA lesion in the common marmoset monkey (Callithrix jacchus). Experimental Neurology. 184: 536-48. PMID 14637123 DOI: 10.1016/j.expneurol.2003.08.007  0.44
2003 Gustafsson E, Andsberg G, Darsalia V, Mohapel P, Mandel RJ, Kirik D, Lindvall O, Kokaia Z. Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke. The European Journal of Neuroscience. 17: 2667-78. PMID 12823474 DOI: 10.1046/j.1460-9568.2003.02713.x  0.44
2003 Matalon R, Surendran S, Rady PL, Quast MJ, Campbell GA, Matalon KM, Tyring SK, Wei J, Peden CS, Ezell EL, Muzyczka N, Mandel RJ. Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for canavan disease. Molecular Therapy : the Journal of the American Society of Gene Therapy. 7: 580-7. PMID 12718900 DOI: 10.1016/S1525-0016(03)00066-2  0.44
2003 Kirik D, Annett LE, Burger C, Muzyczka N, Mandel RJ, Björklund A. Nigrostriatal alpha-synucleinopathy induced by viral vector-mediated overexpression of human alpha-synuclein: a new primate model of Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 2884-9. PMID 12601150 DOI: 10.1073/pnas.0536383100  0.44
2002 Larsson E, Mandel RJ, Klein RL, Muzyczka N, Lindvall O, Kokaia Z. Suppression of insult-induced neurogenesis in adult rat brain by brain-derived neurotrophic factor. Experimental Neurology. 177: 1-8. PMID 12429205 DOI: 10.1006/exnr.2002.7992  0.44
2002 Owen R, Mandel RJ, Ammini CV, Conlon TJ, Kerr DS, Stacpoole PW, Flotte TR. Gene therapy for pyruvate dehydrogenase E1alpha deficiency using recombinant adeno-associated virus 2 (rAAV2) vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 394-9. PMID 12231176 DOI: 10.1006/mthe.2002.0683  0.44
2002 Kirik D, Rosenblad C, Burger C, Lundberg C, Johansen TE, Muzyczka N, Mandel RJ, Björklund A. Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2780-91. PMID 11923443  0.44
2002 Kirik D, Georgievska B, Burger C, Winkler C, Muzyczka N, Mandel RJ, Bjorklund A. Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. Proceedings of the National Academy of Sciences of the United States of America. 99: 4708-13. PMID 11917105 DOI: 10.1073/pnas.062047599  0.44
2002 Andsberg G, Kokaia Z, Klein RL, Muzyczka N, Lindvall O, Mandel RJ. Neuropathological and behavioral consequences of adeno-associated viral vector-mediated continuous intrastriatal neurotrophin delivery in a focal ischemia model in rats. Neurobiology of Disease. 9: 187-204. PMID 11895371 DOI: 10.1006/nbdi.2001.0456  0.44
2000 Englund U, Ericson C, Rosenblad C, Mandel RJ, Trono D, Wictorin K, Lundberg C. The use of a recombinant lentiviral vector for ex vivo gene transfer into the rat CNS. Neuroreport. 11: 3973-7. PMID 11192612  0.44
2000 Björklund A, Kirik D, Rosenblad C, Georgievska B, Lundberg C, Mandel RJ. Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model. Brain Research. 886: 82-98. PMID 11119690 DOI: 10.1016/S0006-8993(00)02915-2  0.44
2000 Klein RL, Mandel RJ, Muzyczka N. Adeno-associated virus vector-mediated gene transfer to somatic cells in the central nervous system. Advances in Virus Research. 55: 507-28. PMID 11050954  0.44
2000 Chen EY, Kallwitz E, Leff SE, Cochran EJ, Mufson EJ, Kordower JH, Mandel RJ. Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. The Journal of Comparative Neurology. 426: 534-48. PMID 11027397 DOI: 10.1002/1096-9861(20001030)426:4<534::AID-CNE3>3.0.CO;2-G  0.44
2000 Kirik D, Rosenblad C, Bjorklund A, Mandel RJ. Long-term rAAV-mediated gene transfer of GDNF in the rat Parkinson's model: intrastriatal but not intranigral transduction promotes functional regeneration in the lesioned nigrostriatal system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 4686-700. PMID 10844038  0.44
2000 Mandel RJ. Effect of acute L-Dopa pretreatment on apomorphine-induced rotational behavior in a rat model of Parkinson's disease. Experimental Neurology. 161: 212-9. PMID 10683287 DOI: 10.1006/exnr.1999.7245  0.44
1999 Mandel RJ, Snyder RO, Leff SE. Recombinant adeno-associated viral vector-mediated glial cell line-derived neurotrophic factor gene transfer protects nigral dopamine neurons after onset of progressive degeneration in a rat model of Parkinson's disease. Experimental Neurology. 160: 205-14. PMID 10630205 DOI: 10.1006/exnr.1999.7203  0.44
1999 Mandel RJ, Rendahl KG, Snyder RO, Leff SE. Progress in direct striatal delivery of L-dopa via gene therapy for treatment of Parkinson's disease using recombinant adeno-associated viral vectors. Experimental Neurology. 159: 47-64. PMID 10486174 DOI: 10.1006/exnr.1999.7159  0.44
1999 Leff SE, Spratt SK, Snyder RO, Mandel RJ. Long-term restoration of striatal L-aromatic amino acid decarboxylase activity using recombinant adeno-associated viral vector gene transfer in a rodent model of Parkinson's disease. Neuroscience. 92: 185-96. PMID 10392841 DOI: 10.1016/S0306-4522(98)00741-6  0.44
1999 Szczypka MS, Mandel RJ, Donahue BA, Snyder RO, Leff SE, Palmiter RD. Viral gene delivery selectively restores feeding and prevents lethality of dopamine-deficient mice. Neuron. 22: 167-78. PMID 10027299 DOI: 10.1016/S0896-6273(00)80688-1  0.44
1999 Mandel RJ, Gage FH, Clevenger DG, Spratt SK, Snyder RO, Leff SE. Nerve growth factor expressed in the medial septum following in vivo gene delivery using a recombinant adeno-associated viral vector protects cholinergic neurons from fimbria-fornix lesion-induced degeneration. Experimental Neurology. 155: 59-64. PMID 9918705 DOI: 10.1006/exnr.1998.6961  0.44
1998 Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L, Trono D. Self-inactivating lentivirus vector for safe and efficient in vivo gene delivery. Journal of Virology. 72: 9873-80. PMID 9811723  0.44
1998 Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, Trono D, Naldini L. A third-generation lentivirus vector with a conditional packaging system. Journal of Virology. 72: 8463-71. PMID 9765382  0.44
1998 Rendahl KG, Leff SE, Otten GR, Spratt SK, Bohl D, Van Roey M, Donahue BA, Cohen LK, Mandel RJ, Danos O, Snyder RO. Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nature Biotechnology. 16: 757-61. PMID 9702775 DOI: 10.1038/nbt0898-757  0.44
1998 Leff SE, Rendahl KG, Spratt SK, Kang UJ, Mandel RJ. In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylase. Experimental Neurology. 151: 249-64. PMID 9628761 DOI: 10.1006/exnr.1998.6803  0.44
1998 Mandel RJ, Rendahl KG, Spratt SK, Snyder RO, Cohen LK, Leff SE. Characterization of intrastriatal recombinant adeno-associated virus-mediated gene transfer of human tyrosine hydroxylase and human GTP-cyclohydrolase I in a rat model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 4271-84. PMID 9592104  0.44
1997 Mandel RJ, Spratt SK, Snyder RO, Leff SE. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proceedings of the National Academy of Sciences of the United States of America. 94: 14083-8. PMID 9391156  0.44
1997 Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D. Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo. Nature Biotechnology. 15: 871-5. PMID 9306402 DOI: 10.1038/nbt0997-871  0.44
1997 Bankiewicz KS, Leff SE, Nagy D, Jungles S, Rokovich J, Spratt K, Cohen L, Libonati M, Snyder RO, Mandel RJ. Practical aspects of the development of ex vivo and in vivo gene therapy for Parkinson's disease. Experimental Neurology. 144: 147-56. PMID 9126164 DOI: 10.1006/exnr.1996.6401  0.44
1995 Ott DA, Mandel RJ. Amphetamine sensitivity in open-field activity vs. the prepulse inhibition paradigm. Brain Research Bulletin. 37: 219-22. PMID 7606498 DOI: 10.1016/0361-9230(94)00276-7  0.44
1994 Mandel RJ, Leanza G, Nilsson OG, Rosengren E. Amphetamine induces excess release of striatal acetylcholine in vivo that is independent of nigrostriatal dopamine. Brain Research. 653: 57-65. PMID 7982076 DOI: 10.1016/0006-8993(94)90372-7  0.44
1993 Bankiewicz K, Mandel RJ, Sofroniew MV. Trophism, transplantation, and animal models of Parkinson's disease. Experimental Neurology. 124: 140-9. PMID 8282071 DOI: 10.1006/exnr.1993.1185  0.44
1993 Mandel RJ, Hartgraves SL, Severson JA, Woodward JJ, Wilcox RE, Randall PK. A quantitative estimate of the role of striatal D-2 receptor proliferation in dopaminergic behavioral supersensitivity: the contribution of mesolimbic dopamine to the magnitude of 6-OHDA lesion-induced agonist sensitivity in the rat. Behavioural Brain Research. 59: 53-64. PMID 8155293 DOI: 10.1016/0166-4328(93)90151-F  0.44
1993 Campbell K, Kalén P, Wictorin K, Lundberg C, Mandel RJ, Björklund A. Characterization of GABA release from intrastriatal striatal transplants: dependence on host-derived afferents. Neuroscience. 53: 403-15. PMID 8098510 DOI: 10.1016/0306-4522(93)90204-S  0.44
1992 Langlais PJ, Mandel RJ, Mair RG. Diencephalic lesions, learning impairments, and intact retrograde memory following acute thiamine deficiency in the rat. Behavioural Brain Research. 48: 177-85. PMID 1616608 DOI: 10.1016/S0166-4328(05)80155-X  0.44
1992 Mandel RJ, Wilcox RE, Randall PK. Behavioral quantification of striatal dopaminergic supersensitivity after bilateral 6-hydroxydopamine lesions in the mouse. Pharmacology, Biochemistry, and Behavior. 41: 343-7. PMID 1574523 DOI: 10.1016/0091-3057(92)90108-R  0.44
1992 Mandel RJ, Wictorin K, Cenci MA, Björklund A. Fos expression in intrastriatal striatal grafts: regulation by host dopaminergic afferents. Brain Research. 583: 207-15. PMID 1504828  0.44
1992 Cenci MA, Kalén P, Mandel RJ, Björklund A. Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat. Brain Research. 581: 217-28. PMID 1393530 DOI: 10.1016/0006-8993(92)90711-H  0.44
1992 Cenci MA, Kalén P, Mandel RJ, Wictorin K, Björklund A. Dopaminergic transplants normalize amphetamine- and apomorphine-induced Fos expression in the 6-hydroxydopamine-lesioned striatum. Neuroscience. 46: 943-57. PMID 1347413 DOI: 10.1016/0306-4522(92)90196-9  0.44
1992 Connor DJ, Thal LJ, Mandel RJ, Langlais PJ, Masliah E. Independent effects of age and nucleus basalis magnocellularis lesion: maze learning, cortical neurochemistry, and morphometry. Behavioral Neuroscience. 106: 776-88. PMID 1280146 DOI: 10.1037/0735-7044.106.5.776  0.44
1990 Mandel RJ, Brundin P, Björklund A. The Importance of Graft Placement and Task Complexity for Transplant-Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats. The European Journal of Neuroscience. 2: 888-894. PMID 12106096  0.44
1990 Thal LJ, Mandel RJ, Terry RD, Buzsaki G, Gage FH. Nucleus basalis lesions fail to induce senile plaques in the rat. Experimental Neurology. 108: 88-90. PMID 2318291 DOI: 10.1016/0014-4886(90)90013-I  0.44
1990 Mandel RJ, Yurek DM, Randall PK. Behavioral demonstration of a reciprocal interaction between dopamine receptor subtypes in the mouse striatum: possible involvement of the striato-nigral pathway. Brain Research Bulletin. 25: 285-92. PMID 2146002 DOI: 10.1016/0361-9230(90)90073-9  0.44
1990 Mandel RJ, Randall PK. Bromocriptine-induced rotation: characterization using a striatal efferent lesion in the mouse. Brain Research Bulletin. 24: 175-80. PMID 2108786 DOI: 10.1016/0361-9230(90)90202-B  0.44
1989 Mandel RJ, Gage FH, Thal LJ. Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen. Behavioural Brain Research. 31: 221-9. PMID 2914073 DOI: 10.1016/0166-4328(89)90004-1  0.44
1989 Mandel RJ, Chen AD, Connor DJ, Thal LJ. Continuous physostigmine infusion in rats with excitotoxic lesions of the nucleus basalis magnocellularis: effects on performance in the water maze task and cortical cholinergic markers. The Journal of Pharmacology and Experimental Therapeutics. 251: 612-9. PMID 2810114  0.44
1989 Buzsàki G, Bickford RG, Ryan LJ, Young S, Prohaska O, Mandel RJ, Gage FH. Multisite recording of brain field potentials and unit activity in freely moving rats. Journal of Neuroscience Methods. 28: 209-17. PMID 2755179 DOI: 10.1016/0165-0270(89)90038-1  0.44
1989 Mandel RJ, Gage FH, Thal LJ. Spatial learning in rats: correlation with cortical choline acetyltransferase and improvement with NGF following NBM damage. Experimental Neurology. 104: 208-17. PMID 2721623 DOI: 10.1016/0014-4886(89)90031-9  0.44
1988 Mandel RJ, Thal LJ. Physostigmine improves water maze performance following nucleus basalis magnocellularis lesions in rats. Psychopharmacology. 96: 421-5. PMID 3146779 DOI: 10.1007/BF00216074  0.44
1987 May PC, Osterburg HH, Mandel RJ, Morgan DG, Randall PK, Finch CE. Alteration of calmodulin distribution does not accompany dopaminergic supersensitization of the mouse striatum. Journal of Neuroscience Research. 17: 247-50. PMID 3037094 DOI: 10.1002/jnr.490170307  0.44
1985 Mandel RJ, Randall PK. Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in the mouse. Brain Research. 330: 358-63. PMID 3921193 DOI: 10.1016/0006-8993(85)90698-5  0.44
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