Rachael Pearson - Publications

Inst Ophthalmology, UCL, London, England, United Kingdom 

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Aldunate EZ, Di Foggia V, Di Marco F, Hervas LA, Ribeiro JC, Holder DL, Patel A, Jannini TB, Thompson DA, Martinez-Barbera JP, Pearson RA, Ali RR, Sowden JC. Conditional Dicer1 depletion using Chrnb4-Cre leads to cone cell death and impaired photopic vision. Scientific Reports. 9: 2314. PMID 30783126 DOI: 10.1038/s41598-018-38294-9  0.88
2018 Pearson RA, Ali RR. Unlocking the Potential for Endogenous Repair to Restore Sight. Neuron. 100: 524-526. PMID 30408440 DOI: 10.1016/j.neuron.2018.10.035  0.88
2018 Graca AB, Hippert C, Pearson RA. Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions. Advances in Experimental Medicine and Biology. 1074: 303-308. PMID 29721957 DOI: 10.1007/978-3-319-75402-4_37  0.8
2018 Kleine Holthaus SM, Ribeiro J, Abelleira-Hervas L, Pearson RA, Duran Y, Georgiadis A, Sampson RD, Rizzi M, Hoke J, Maswood R, Azam S, Luhmann UFO, Smith AJ, Mole SE, Ali RR. Prevention of Photoreceptor Cell Loss in a Cln6Mouse Model of Batten Disease Requires CLN6 Gene Transfer to Bipolar Cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 29606505 DOI: 10.1016/j.ymthe.2018.02.027  0.88
2018 Gonzalez Cordero A, Goh D, Kruczek K, Naeem A, Fernando M, Kleine Holthaus SM, Takaaki M, Blackford SJI, Kloc M, Agundez L, Sampson RD, Borooah S, Ovando-Roche P, Mehat MS, West EL, ... ... Pearson RA, et al. Assessment of AAV vector tropisms for mouse and human pluripotent stem cell-derived RPE and photoreceptor cells. Human Gene Therapy. PMID 29580100 DOI: 10.1089/hum.2018.027  0.88
2018 Waldron PV, Di Marco F, Kruczek K, Ribeiro J, Graca AB, Hippert C, Aghaizu ND, Kalargyrou AA, Barber AC, Grimaldi G, Duran Y, Blackford SJI, Kloc M, Goh D, Zabala Aldunate E, ... ... Pearson RA, et al. Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner. Stem Cell Reports. PMID 29307580 DOI: 10.1016/j.stemcr.2017.12.008  0.88
2017 Gonzalez-Cordero A, Kruczek K, Naeem A, Fernando M, Kloc M, Ribeiro J, Goh D, Duran Y, Blackford SJI, Abelleira-Hervas L, Sampson RD, Shum IO, Branch MJ, Gardner PJ, Sowden JC, ... ... Pearson RA, et al. Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors. Stem Cell Reports. PMID 28844659 DOI: 10.1016/j.stemcr.2017.07.022  0.88
2017 Ovando-Roche P, Georgiadis A, Smith AJ, Pearson RA, Ali RR. Harnessing the Potential of Human Pluripotent Stem Cells and Gene Editing for the Treatment of Retinal Degeneration. Current Stem Cell Reports. 3: 112-123. PMID 28596937 DOI: 10.1007/s40778-017-0078-4  0.88
2017 Aghaizu ND, Kruczek K, Gonzalez-Cordero A, Ali RR, Pearson RA. Pluripotent stem cells and their utility in treating photoreceptor degenerations. Progress in Brain Research. 231: 191-223. PMID 28554397 DOI: 10.1016/bs.pbr.2017.01.001  0.88
2017 Kruczek K, Gonzalez-Cordero A, Goh D, Naeem A, Jonikas M, Blackford SJI, Kloc M, Duran Y, Georgiadis A, Sampson RD, Maswood RN, Smith AJ, Decembrini S, Arsenijevic Y, Sowden JC, ... Pearson RA, et al. Differentiation and Transplantation of Embryonic Stem Cell-Derived Cone Photoreceptors into a Mouse Model of End-Stage Retinal Degeneration. Stem Cell Reports. PMID 28552606 DOI: 10.1016/j.stemcr.2017.04.030  0.88
2017 Athanasiou D, Aguila M, Opefi CA, South K, Bellingham J, Bevilacqua D, Munro PM, Kanuga N, Mackenzie FE, Dubis AM, Georgiadis A, Graca AB, Pearson RA, Ali RR, Sakami S, et al. Rescue of mutant rhodopsin traffic by metformin-induced AMPK activation accelerates photoreceptor degeneration. Human Molecular Genetics. PMID 28065882 DOI: 10.1093/hmg/ddw387  0.88
2016 Hippert C, Graca AB, Pearson RA. Gliosis Can Impede Integration Following Photoreceptor Transplantation into the Diseased Retina. Advances in Experimental Medicine and Biology. 854: 579-85. PMID 26427462 DOI: 10.1007/978-3-319-17121-0_77  0.88
2015 Lakowski J, Gonzalez-Cordero A, West EL, Han YT, Welby E, Naeem A, Blackford SJ, Bainbridge JW, Pearson RA, Ali RR, Sowden JC. Transplantation of Photoreceptor Precursors Isolated via a Cell Surface Biomarker Panel From Embryonic Stem Cell-Derived Self-Forming Retina. Stem Cells (Dayton, Ohio). 33: 2469-82. PMID 25982268 DOI: 10.1002/stem.2051  0.88
2015 Hippert C, Graca AB, Barber AC, West EL, Smith AJ, Ali RR, Pearson RA. Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific. Plos One. 10: e0120415. PMID 25793273 DOI: 10.1371/journal.pone.0120415  0.88
2015 Jayakody SA, Gonzalez-Cordero A, Ali RR, Pearson RA. Cellular strategies for retinal repair by photoreceptor replacement. Progress in Retinal and Eye Research. 46: 31-66. PMID 25660226 DOI: 10.1016/j.preteyeres.2015.01.003  0.88
2014 Pearson RA, Hippert C, Graca AB, Barber AC. Photoreceptor replacement therapy: challenges presented by the diseased recipient retinal environment. Visual Neuroscience. 31: 333-44. PMID 24945529 DOI: 10.1017/S0952523814000200  0.88
2014 Pearson RA. Advances in repairing the degenerate retina by rod photoreceptor transplantation. Biotechnology Advances. 32: 485-91. PMID 24412415 DOI: 10.1016/j.biotechadv.2014.01.001  0.88
2014 Warre-Cornish K, Barber AC, Sowden JC, Ali RR, Pearson RA. Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina. Stem Cells and Development. 23: 941-54. PMID 24328605 DOI: 10.1089/scd.2013.0471  0.88
2013 Gonzalez-Cordero A, West EL, Pearson RA, Duran Y, Carvalho LS, Chu CJ, Naeem A, Blackford SJ, Georgiadis A, Lakowski J, Hubank M, Smith AJ, Bainbridge JW, Sowden JC, Ali RR. Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina. Nature Biotechnology. 31: 741-7. PMID 23873086 DOI: 10.1038/nbt.2643  0.88
2013 Barber AC, Hippert C, Duran Y, West EL, Bainbridge JW, Warre-Cornish K, Luhmann UF, Lakowski J, Sowden JC, Ali RR, Pearson RA. Repair of the degenerate retina by photoreceptor transplantation. Proceedings of the National Academy of Sciences of the United States of America. 110: 354-9. PMID 23248312 DOI: 10.1073/pnas.1212677110  0.88
2012 West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M, Ali RR. Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells (Dayton, Ohio). 30: 1424-35. PMID 22570183 DOI: 10.1002/stem.1123  0.88
2012 Pearson RA, Barber AC, Rizzi M, Hippert C, Xue T, West EL, Duran Y, Smith AJ, Chuang JZ, Azam SA, Luhmann UF, Benucci A, Sung CH, Bainbridge JW, Carandini M, et al. Restoration of vision after transplantation of photoreceptors. Nature. 485: 99-103. PMID 22522934 DOI: 10.1038/nature10997  0.88
2012 West EL, Pearson RA, Duran Y, Gonzalez-Cordero A, MacLaren RE, Smith AJ, Sowden JC, Ali RR. Manipulation of the recipient retinal environment by ectopic expression of neurotrophic growth factors can improve transplanted photoreceptor integration and survival. Cell Transplantation. 21: 871-87. PMID 22325046 DOI: 10.3727/096368911X623871  0.88
2011 Gualdoni S, Baron M, Lakowski J, Decembrini S, Pearson RA, Ali RR, Sowden JC. Isolation and culture of adult ciliary epithelial cells, previously identified as retinal stem cells, and retinal progenitor cells. Current Protocols in Stem Cell Biology. Unit 1H.4. PMID 22135083 DOI: 10.1002/9780470151808.sc01h04s19  0.88
2011 Lakowski J, Han YT, Pearson RA, Gonzalez-Cordero A, West EL, Gualdoni S, Barber AC, Hubank M, Ali RR, Sowden JC. Effective transplantation of photoreceptor precursor cells selected via cell surface antigen expression. Stem Cells (Dayton, Ohio). 29: 1391-404. PMID 21774040 DOI: 10.1002/stem.694  0.88
2011 Mihelec M, Pearson RA, Robbie SJ, Buch PK, Azam SA, Bainbridge JW, Smith AJ, Ali RR. Long-term preservation of cones and improvement in visual function following gene therapy in a mouse model of leber congenital amaurosis caused by guanylate cyclase-1 deficiency. Human Gene Therapy. 22: 1179-90. PMID 21671801 DOI: 10.1089/hum.2011.069  0.88
2011 Carvalho LS, Xu J, Pearson RA, Smith AJ, Bainbridge JW, Morris LM, Fliesler SJ, Ding XQ, Ali RR. Long-term and age-dependent restoration of visual function in a mouse model of CNGB3-associated achromatopsia following gene therapy. Human Molecular Genetics. 20: 3161-75. PMID 21576125 DOI: 10.1093/hmg/ddr218  0.88
2011 Buch PK, Mihelec M, Cottrill P, Wilkie SE, Pearson RA, Duran Y, West EL, Michaelides M, Ali RR, Hunt DM. Dominant cone-rod dystrophy: a mouse model generated by gene targeting of the GCAP1/Guca1a gene. Plos One. 6: e18089. PMID 21464903 DOI: 10.1371/journal.pone.0018089  0.88
2011 Decembrini S, Cananzi M, Gualdoni S, Battersby A, Allen N, Pearson RA, Ali RR, De Coppi P, Sowden JC. Comparative analysis of the retinal potential of embryonic stem cells and amniotic fluid-derived stem cells. Stem Cells and Development. 20: 851-63. PMID 20939691 DOI: 10.1089/scd.2010.0291  0.88
2010 Lakowski J, Baron M, Bainbridge J, Barber AC, Pearson RA, Ali RR, Sowden JC. Cone and rod photoreceptor transplantation in models of the childhood retinopathy Leber congenital amaurosis using flow-sorted Crx-positive donor cells. Human Molecular Genetics. 19: 4545-59. PMID 20858907 DOI: 10.1093/hmg/ddq378  0.88
2010 West EL, Pearson RA, Barker SE, Luhmann UF, Maclaren RE, Barber AC, Duran Y, Smith AJ, Sowden JC, Ali RR. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation. Stem Cells (Dayton, Ohio). 28: 1997-2007. PMID 20857496 DOI: 10.1002/stem.520  0.88
2010 Gualdoni S, Baron M, Lakowski J, Decembrini S, Smith AJ, Pearson RA, Ali RR, Sowden JC. Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors. Stem Cells (Dayton, Ohio). 28: 1048-59. PMID 20506130 DOI: 10.1002/stem.423  0.88
2010 Pearson RA, Barber AC, West EL, MacLaren RE, Duran Y, Bainbridge JW, Sowden JC, Ali RR. Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina. Cell Transplantation. 19: 487-503. PMID 20089206 DOI: 10.3727/096368909X486057  0.88
2009 West EL, Pearson RA, MacLaren RE, Sowden JC, Ali RR. Cell transplantation strategies for retinal repair. Progress in Brain Research. 175: 3-21. PMID 19660645 DOI: 10.1016/S0079-6123(09)17501-5  0.88
2008 Kokkinopoulos I, Pearson RA, Macneil A, Dhomen NS, MacLaren RE, Ali RR, Sowden JC. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina. Molecular and Cellular Neurosciences. 38: 359-73. PMID 18514541 DOI: 10.1016/j.mcn.2008.03.008  0.88
2008 West EL, Pearson RA, Tschernutter M, Sowden JC, MacLaren RE, Ali RR. Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors. Experimental Eye Research. 86: 601-11. PMID 18294631 DOI: 10.1016/j.exer.2008.01.004  0.88
2008 Martins RA, Pearson RA. Control of cell proliferation by neurotransmitters in the developing vertebrate retina. Brain Research. 1192: 37-60. PMID 17597590 DOI: 10.1016/j.brainres.2007.04.076  0.32
2007 MacNeil A, Pearson RA, MacLaren RE, Smith AJ, Sowden JC, Ali RR. Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye. Stem Cells (Dayton, Ohio). 25: 2430-8. PMID 17600111 DOI: 10.1634/stemcells.2007-0035  0.88
2006 Dhomen NS, Balaggan KS, Pearson RA, Bainbridge JW, Levine EM, Ali RR, Sowden JC. Absence of chx10 causes neural progenitors to persist in the adult retina. Investigative Ophthalmology & Visual Science. 47: 386-96. PMID 16384989 DOI: 10.1167/iovs.05-0428  0.32
2005 Pearson RA, Dale N, Llaudet E, Mobbs P. ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron. 46: 731-44. PMID 15924860 DOI: 10.1016/j.neuron.2005.04.024  0.32
2004 Pearson RA, Catsicas M, Becker DL, Bayley P, Lüneborg NL, Mobbs P. Ca(2+) signalling and gap junction coupling within and between pigment epithelium and neural retina in the developing chick. The European Journal of Neuroscience. 19: 2435-45. PMID 15128397 DOI: 10.1111/j.0953-816X.2004.03338.x  0.32
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