Edward B. Lee, MD PhD - Publications

Affiliations: 
Pathology and Laboratory Medicine University of Pennsylvania, Philadelphia, PA, United States 
Website:
http://www.med.upenn.edu/cndr/AlphaStaffListing.shtml#L

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Year Citation  Score
2019 Caswell C, McMillan CT, Xie SX, Van Deerlin VM, Suh E, Lee EB, Trojanowski JQ, Lee VM, Irwin DJ, Grossman M, Massimo LM. Genetic predictors of survival in behavioral variant frontotemporal degeneration. Neurology. PMID 31537715 DOI: 10.1212/WNL.0000000000008387  0.76
2019 Giannini LAA, Xie SX, Peterson C, Zhou C, Lee EB, Wolk DA, Grossman M, Trojanowski JQ, McMillan CT, Irwin DJ. Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration. Frontiers in Neuroscience. 13: 682. PMID 31333403 DOI: 10.3389/fnins.2019.00682  0.76
2019 Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, ... ... Lee EB, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathologica. PMID 31327044 DOI: 10.1007/s00401-019-02045-5  0.76
2019 Lee EB, Kinch K, Johnson VE, Trojanowski JQ, Smith DH, Stewart W. Chronic traumatic encephalopathy is a common co-morbidity, but less frequent primary dementia in former soccer and rugby players. Acta Neuropathologica. PMID 31152201 DOI: 10.1007/s00401-019-02030-y  0.76
2019 Phillips JS, Da Re F, Irwin DJ, McMillan CT, Vaishnavi SN, Xie SX, Lee EB, Cook PA, Gee JC, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Longitudinal progression of grey matter atrophy in non-amnestic Alzheimer's disease. Brain : a Journal of Neurology. 142: 1701-1722. PMID 31135048 DOI: 10.1093/brain/awz091  0.76
2019 Viaene AN, Lee EB, Rosenbaum JN, Nasrallah IM, Nasrallah MP. Histologic, immunohistochemical, and molecular features of pituicytomas and atypical pituicytomas. Acta Neuropathologica Communications. 7: 69. PMID 31046843 DOI: 10.1186/s40478-019-0722-6  0.32
2019 Liu EY, Russ J, Cali CP, Phan JM, Amlie-Wolf A, Lee EB. Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons. Cell Reports. 27: 1409-1421.e6. PMID 31042469 DOI: 10.1016/j.celrep.2019.04.003  0.36
2019 Giannini LA, Xie SX, McMillan CT, Liang M, Williams A, Jester C, Rascovsky K, Wolk DA, Ash S, Lee EB, Trojanowski JQ, Grossman M, Irwin DJ. Divergent Patterns of TDP-43 and Tau Pathologies in Primary Progressive Aphasia. Annals of Neurology. PMID 30851133 DOI: 10.1002/ana.25465  0.76
2019 Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, ... ... Lee EB, et al. Primum non nocere: a call for balance when reporting on CTE. The Lancet. Neurology. 18: 231-233. PMID 30784550 DOI: 10.1016/S1474-4422(19)30020-1  0.76
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Lee EB, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/s00401-019-01962-9  0.76
2018 Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, ... Lee EB, et al. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Annals of Neurology. PMID 30549331 DOI: 10.1002/ana.25392  0.76
2018 Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 73: 190-199. PMID 30368160 DOI: 10.1016/j.neurobiolaging.2018.09.031  0.76
2018 Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo. Nature Communications. 9: 4220. PMID 30310141 DOI: 10.1038/s41467-018-06548-9  0.76
2018 Alcolea D, Irwin DJ, Illán-Gala I, Muñoz L, Clarimón J, McMillan CT, Fortea J, Blesa R, Lee EB, Trojanowski JQ, Grossman M, Lleó A. Elevated YKL-40 and low sAPPβ:YKL-40 ratio in antemortem cerebrospinal fluid of patients with pathologically confirmed FTLD. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 30297518 DOI: 10.1136/jnnp-2018-318993  0.76
2018 Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ. Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy. Journal of Neuropathology and Experimental Neurology. PMID 30203094 DOI: 10.1093/jnen/nly080  0.76
2018 McMillan CT, Lee EB, Jefferson-George K, Naj A, Van Deerlin VM, Trojanowski JQ, Wolk DA. Alzheimer's genetic risk is reduced in primary age-related tauopathy: a potential model of resistance? Annals of Clinical and Translational Neurology. 5: 927-934. PMID 30128317 DOI: 10.1002/acn3.581  0.76
2018 Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta Neuropathologica Communications. 6: 50. PMID 29891013 DOI: 10.1186/s40478-018-0552-y  0.76
2018 Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, et al. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a Journal of Neurology. PMID 29878075 DOI: 10.1093/brain/awy146  0.76
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Lee EB, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.76
2018 Shi M, Tang L, Toledo JB, Ginghina C, Wang H, Aro P, Jensen PH, Weintraub D, Chen-Plotkin AS, Irwin DJ, Grossman M, McCluskey L, Elman LB, Wolk DA, Lee EB, et al. Cerebrospinal fluid α-synuclein contributes to the differential diagnosis of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29604263 DOI: 10.1016/j.jalz.2018.02.015  0.76
2018 Lleó A, Irwin DJ, Illán-Gala I, McMillan CT, Wolk DA, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. A 2-Step Cerebrospinal Algorithm for the Selection of Frontotemporal Lobar Degeneration Subtypes. Jama Neurology. PMID 29554190 DOI: 10.1001/jamaneurol.2018.0118  0.76
2018 Irwin DJ, Xie SX, Coughlin D, Nevler N, Akhtar RS, McMillan CT, Lee EB, Wolk DA, Weintraub D, Chen-Plotkin A, Duda JE, Spindler M, Siderowf A, Hurtig HI, Shaw LM, et al. CSF tau and amyloid-beta predict cerebral synucleinopathy in autopsied Lewy body disorders. Neurology. PMID 29467305 DOI: 10.1212/WNL.0000000000005166  0.76
2017 Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre G, Lee EB, Lee VMY, Trojanowski JQ, Grossman M. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29228211 DOI: 10.1093/brain/awx319  0.76
2017 Phillips JS, Da Re F, Dratch L, Xie SX, Irwin DJ, McMillan CT, Vaishnavi SN, Ferrarese C, Lee EB, Shaw LM, Trojanowski JQ, Wolk DA, Grossman M. Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease. Neurobiology of Aging. 63: 75-87. PMID 29223682 DOI: 10.1016/j.neurobiolaging.2017.11.008  0.76
2017 Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 68. PMID 28877758 DOI: 10.1186/s40478-017-0471-3  0.76
2017 Irwin DJ, Lleó A, Xie SX, McMillan CT, Wolk D, Lee EB, Van Deerlin VM, Shaw LM, Trojanowski JQ, Grossman M. Ante mortem CSF tau levels correlate with post mortem tau pathology in FTLD. Annals of Neurology. PMID 28719018 DOI: 10.1002/ana.24996  0.76
2017 Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. PMID 28669544 DOI: 10.1016/j.neuron.2017.05.037  0.76
2017 Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, et al. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). Journal of Neuropathology and Experimental Neurology. PMID 28591867 DOI: 10.1093/jnen/nlx041  0.76
2017 Giannini LAA, Irwin DJ, McMillan CT, Ash S, Rascovsky K, Wolk DA, Van Deerlin VM, Lee EB, Trojanowski JQ, Grossman M. Clinical marker for Alzheimer disease pathology in logopenic primary progressive aphasia. Neurology. PMID 28515265 DOI: 10.1212/WNL.0000000000004034  0.76
2017 Bonini NM, Lee EB, Wasco W, Roses AD. Editorial overview: Molecular & genetic basis of disease. Current Opinion in Genetics & Development. PMID 28473186 DOI: 10.1016/j.gde.2017.04.003  0.56
2017 Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, et al. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 28340083 DOI: 10.1093/jnen/nlx007  0.76
2017 Jefferson-George KS, Wolk DA, Lee EB, McMillan CT. Cognitive decline associated with pathological burden in primary age-related tauopathy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28322204 DOI: 10.1016/j.jalz.2017.01.028  0.56
2017 Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica. PMID 28130640 DOI: 10.1007/s00401-017-1679-9  0.76
2017 Irwin DJ, Grossman M, Weintraub D, Hurtig HI, Duda JE, Xie SX, Lee EB, Van Deerlin VM, Lopez OL, Kofler JK, Nelson PT, Jicha GA, Woltjer R, Quinn JF, Kaye J, et al. Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis. The Lancet. Neurology. 16: 55-65. PMID 27979356 DOI: 10.1016/S1474-4422(16)30291-5  0.76
2016 Spotorno N, McMillan CT, Irwin DJ, Clark R, Lee EB, Trojanowski JQ, Weintraub D, Grossman M. Decision-Making Deficits Associated with Amyloidosis in Lewy Body Disorders. Frontiers in Human Neuroscience. 10: 693. PMID 28123364 DOI: 10.3389/fnhum.2016.00693  0.76
2016 Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology (Zurich, Switzerland). PMID 28019685 DOI: 10.1111/bpa.12482  0.76
2016 McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M. Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta Neuropathologica. PMID 27815633 DOI: 10.1007/s00401-016-1640-3  0.76
2016 Brettschneider J, Irwin DJ, Boluda S, Byrne MD, Fang L, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Toledo JB, Grossman M, Hurtig H, Dengler R, Petri S, Lee VM, et al. Progression of alpha-synuclein pathology in multiple system atrophy of the cerebellar type. Neuropathology and Applied Neurobiology. PMID 27716988 DOI: 10.1111/nan.12362  0.76
2016 Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT. Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology. PMID 27683847 DOI: 10.1212/WNL.0000000000003250  0.76
2016 McMillan CT, Boyd C, Gross RG, Weinstein J, Firn K, Toledo JB, Rascovsky K, Shaw L, Wolk DA, Irwin DJ, Lee EB, Trojanowski JQ, Grossman M. Multimodal imaging evidence of pathology-mediated disease distribution in corticobasal syndrome. Neurology. PMID 27543644 DOI: 10.1212/WNL.0000000000003119  0.76
2015 Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica. PMID 26721587 DOI: 10.1007/s00401-015-1526-9  0.76
2015 Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, ... ... Lee EB, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathologica. PMID 26659578 DOI: 10.1007/s00401-015-1509-x  0.76
2015 Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep Clinical and Neuropathological Phenotyping of Pick's Disease. Annals of Neurology. PMID 26583316 DOI: 10.1002/ana.24559  0.36
2015 Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26538548 DOI: 10.1369/0022155415614303  0.36
2015 Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. Plos One. 10: e0141836. PMID 26510133 DOI: 10.1371/journal.pone.0141836  0.76
2015 Montine TJ, Monsell SE, Beach TG, Bigio EH, Bu Y, Cairns NJ, Frosch M, Henriksen J, Kofler J, Kukull WA, Lee EB, Nelson PT, Schantz AM, Schneider JA, Sonnen JA, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26327235 DOI: 10.1016/j.jalz.2015.07.492  0.76
2015 Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His. Acta Neuropathologica Communications. 3: 42. PMID 26141825 DOI: 10.1186/s40478-015-0219-x  0.76
2015 Suh E, Lee EB, Neal D, Wood EM, Toledo JB, Rennert L, Irwin DJ, McMillan CT, Krock B, Elman LB, McCluskey LF, Grossman M, Xie SX, Trojanowski JQ, Van Deerlin VM. Semi-automated quantification of C9orf72 expansion size reveals inverse correlation between hexanucleotide repeat number and disease duration in frontotemporal degeneration. Acta Neuropathologica. PMID 26022924 DOI: 10.1007/s00401-015-1445-9  0.76
2015 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 129: 929. PMID 25931052 DOI: 10.1007/s00401-015-1428-x  0.76
2015 McMillan CT, Russ J, Wood EM, Irwin DJ, Grossman M, McCluskey L, Elman L, Van Deerlin V, Lee EB. C9orf72 promoter hypermethylation is neuroprotective: Neuroimaging and neuropathologic evidence. Neurology. 84: 1622-30. PMID 25795648 DOI: 10.1212/WNL.0000000000001495  0.76
2015 Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine. Acta Neuropathologica. 129: 469-91. PMID 25549971 DOI: 10.1007/s00401-014-1380-1  0.76
2015 Russ J, Liu EY, Wu K, Neal D, Suh E, Irwin DJ, McMillan CT, Harms MB, Cairns NJ, Wood EM, Xie SX, Elman L, McCluskey L, Grossman M, Van Deerlin VM, ... Lee EB, et al. Hypermethylation of repeat expanded C9orf72 is a clinical and molecular disease modifier. Acta Neuropathologica. 129: 39-52. PMID 25388784 DOI: 10.1007/s00401-014-1365-0  0.76
2014 McGurk L, Lee VM, Trojanowksi JQ, Van Deerlin VM, Lee EB, Bonini NM. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. Journal of Neuropathology and Experimental Neurology. 73: 837-45. PMID 25111021 DOI: 10.1097/NEN.0000000000000102  0.76
2014 Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128: 679-89. PMID 25107476 DOI: 10.1007/s00401-014-1328-5  0.76
2014 Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain : a Journal of Neurology. 137: 2578-87. PMID 25012223 DOI: 10.1093/brain/awu190  0.76
2014 Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128: 543-50. PMID 24916271 DOI: 10.1007/s00401-014-1308-9  0.76
2014 Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, et al. TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128: 423-37. PMID 24916269 DOI: 10.1007/s00401-014-1299-6  0.76
2014 Liu EY, Russ J, Wu K, Neal D, Suh E, McNally AG, Irwin DJ, Van Deerlin VM, Lee EB. C9orf72 hypermethylation protects against repeat expansion-associated pathology in ALS/FTD. Acta Neuropathologica. 128: 525-41. PMID 24806409 DOI: 10.1007/s00401-014-1286-y  0.76
2014 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127: 423-39. PMID 24407427 DOI: 10.1007/s00401-013-1238-y  1
2014 Lee EB, Mattson MP. The neuropathology of obesity: insights from human disease. Acta Neuropathologica. 127: 3-28. PMID 24096619 DOI: 10.1007/s00401-013-1190-x  0.76
2014 Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, et al. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 477-84.e1. PMID 23978324 DOI: 10.1016/j.jalz.2013.06.003  0.76
2013 Wood EM, Falcone D, Suh E, Irwin DJ, Chen-Plotkin AS, Lee EB, Xie SX, Van Deerlin VM, Grossman M. Development and validation of pedigree classification criteria for frontotemporal lobar degeneration. Jama Neurology. 70: 1411-7. PMID 24081456 DOI: 10.1001/jamaneurol.2013.3956  0.76
2013 Lee EB, Russ J, Jung H, Elman LB, Chahine LM, Kremens D, Miller BL, Branch Coslett H, Trojanowski JQ, Van Deerlin VM, McCluskey LF. Topography of FUS pathology distinguishes late-onset BIBD from aFTLD-U. Acta Neuropathologica Communications. 1: 1-11. PMID 24027631 DOI: 10.1186/2051-5960-1-9  0.76
2013 Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of Comparative Neurology. 521: 4339-55. PMID 23881776 DOI: 10.1002/cne.23430  0.76
2013 Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Annals of Neurology. 74: 20-38. PMID 23686809 DOI: 10.1002/ana.23937  0.76
2012 Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM, Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain : a Journal of Neurology. 135: 3749-56. PMID 23204143 DOI: 10.1093/brain/aws271  0.76
2012 Patel S, Lee EB, Xie SX, Law A, Jackson EM, Arnold SE, Clark CM, Shaw LM, Grady MS, Trojanowski JQ, Hamilton RH. Phosphorylated tau/amyloid beta 1-42 ratio in ventricular cerebrospinal fluid reflects outcome in idiopathic normal pressure hydrocephalus. Fluids and Barriers of the Cns. 9: 7. PMID 22444461 DOI: 10.1186/2045-8118-9-7  0.76
2012 Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, Ali YO, Safren N, Monteiro MJ, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina-Porcel L, Lee VM, et al. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathologica. 123: 825-39. PMID 22426854 DOI: 10.1007/s00401-012-0970-z  0.76
2012 Lee EB, Ahima RS. Alteration of hypothalamic cellular dynamics in obesity. The Journal of Clinical Investigation. 122: 22-5. PMID 22201678 DOI: 10.1172/JCI61562  0.76
2012 Lee EB, Lee VM, Trojanowski JQ. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature Reviews. Neuroscience. 13: 38-50. PMID 22127299 DOI: 10.1038/nrn3121  0.76
2011 Lee EB. Obesity, leptin, and Alzheimer's disease. Annals of the New York Academy of Sciences. 1243: 15-29. PMID 22211890 DOI: 10.1111/j.1749-6632.2011.06274.x  0.76
2011 Lee EB, Warmann G, Dhir R, Ahima RS. Metabolic dysfunction associated with adiponectin deficiency enhances kainic acid-induced seizure severity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14361-6. PMID 21976521 DOI: 10.1523/JNEUROSCI.3171-11.2011  0.76
2011 Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10076-87. PMID 21734300 DOI: 10.1523/JNEUROSCI.0618-11.2011  0.76
2011 Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7691-9. PMID 21613482 DOI: 10.1523/JNEUROSCI.6637-10.2011  0.76
2011 Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of Clinical Investigation. 121: 726-38. PMID 21206091 DOI: 10.1172/JCI44867  0.76
2010 Hamilton R, Patel S, Lee EB, Jackson EM, Lopinto J, Arnold SE, Clark CM, Basil A, Shaw LM, Xie SX, Grady MS, Trojanowski JQ. Lack of shunt response in suspected idiopathic normal pressure hydrocephalus with Alzheimer disease pathology. Annals of Neurology. 68: 535-40. PMID 20687117 DOI: 10.1002/ana.22015  0.76
2010 Prasad S, Lee EB, Woo JH, Alavi A, Galetta SL. Photo essay. MRI and positron emission tomography findings in Heidenhain variant Creutzfeldt-Jakob disease. Journal of Neuro-Ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society. 30: 260-2. PMID 20581692 DOI: 10.1097/WNO.0b013e3181e2aef7  0.76
2010 Arnold SE, Lee EB, Moberg PJ, Stutzbach L, Kazi H, Han LY, Lee VM, Trojanowski JQ. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of Neurology. 67: 462-9. PMID 20437581 DOI: 10.1002/ana.21910  0.76
2009 Ranalli NJ, Huang JH, Lee EB, Zhang PJ, Siegelman ES, Zager EL. Hemangiomas of the Brachial Plexus: A Case Series. Neurosurgery. 65: A181-A188. PMID 28180834 DOI: 10.1227/01.NEU.0000335643.41581.1D  0.36
2009 Turkeltaub PE, Guzman MA, Lee EB, Galetta SL. Idiopathic eosinophilic meningoencephalomyelitis following Well syndrome. Neurology. 73: 2037-9. PMID 19996079 DOI: 10.1212/WNL.0b013e3181c55ee7  0.76
2009 Ranalli NJ, Huang JH, Lee EB, Zhang PJ, Siegelman ES, Zager EL. Hemangiomas of the brachial plexus: a case series. Neurosurgery. 65: A181-8. PMID 19927066 DOI: 10.1227/01.NEU.0000335643.41581.1D  0.76
2009 Lee EB, Tihan T, Scheithauer BW, Zhang PJ, Gonatas NK. Thyroid transcription factor 1 expression in sellar tumors: a histogenetic marker? Journal of Neuropathology and Experimental Neurology. 68: 482-8. PMID 19525896 DOI: 10.1097/NEN.0b013e3181a13fca  0.76
2009 Kim AK, Lee EB, Bagley LJ, Loevner LA. Retained surgical sponges after craniotomies: imaging appearances and complications. Ajnr. American Journal of Neuroradiology. 30: 1270-2. PMID 19213821 DOI: 10.3174/ajnr.A1469  0.76
2009 Ko MW, Turkeltaub PE, Lee EB, Gonatas NK, Volpe NJ, Moster ML, Galetta SL. Primary diffuse leptomeningeal gliomatosis mimicking a chronic inflammatory meningitis. Journal of the Neurological Sciences. 278: 127-31. PMID 19135216 DOI: 10.1016/j.jns.2008.11.026  0.76
2009 Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathologica. 117: 137-49. PMID 19125255 DOI: 10.1007/s00401-008-0477-9  0.76
2008 Prasad S, Moss HE, Lee EB, Glisson CC, Galetta SL. Clinical reasoning: a 42-year-old man with sequential monocular visual loss. Neurology. 71: e43-9. PMID 18936420 DOI: 10.1212/01.wnl.0000327690.66003.0a  0.76
2008 Lee EB, Lee VM, Trojanowski JQ, Neumann M. TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta Neuropathologica. 115: 305-11. PMID 18087705 DOI: 10.1007/s00401-007-0331-5  0.76
2007 Prasad S, Ko MW, Lee EB, Gonatas NK, Stern MB, Galetta S. Supranuclear vertical gaze abnormalities in sporadic Creutzfeldt-Jakob disease. Journal of the Neurological Sciences. 253: 69-72. PMID 17234215 DOI: 10.1016/j.jns.2006.11.010  0.76
2006 Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, Lee VM. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of Biological Chemistry. 281: 4292-9. PMID 16361260 DOI: 10.1074/jbc.M511018200  0.76
2005 Lee EB, Leng LZ, Lee VM, Trojanowski JQ. Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. Febs Letters. 579: 2564-8. PMID 15862291 DOI: 10.1016/j.febslet.2005.03.070  0.76
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/JNEUROSCI.3089-04.2005  0.76
2005 Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of Cell Biology. 168: 291-302. PMID 15642747 DOI: 10.1083/jcb.200407070  0.76
2005 Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J, Lee EB, Xie SX, Joyce S, Li C, Toleikis PM, Lee VM, Trojanowski JQ. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America. 102: 227-31. PMID 15615853 DOI: 10.1073/pnas.0406361102  0.76
2004 Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM, Praticò D. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American Journal of Pathology. 165: 2197-206. PMID 15579461  0.76
2004 Jeoung D, Lim Y, Lee EB, Lee S, Kim HY, Lee H, Song YW. Identification of autoantibody against poly (ADP-ribose) polymerase (PARP) fragment as a serological marker in systemic lupus erythematosus. Journal of Autoimmunity. 22: 87-94. PMID 14709417  0.72
2003 Watson DJ, Longhi L, Lee EB, Fulp CT, Fujimoto S, Royo NC, Passini MA, Trojanowski JQ, Lee VM, McIntosh TK, Wolfe JH. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. Journal of Neuropathology and Experimental Neurology. 62: 368-80. PMID 12722829  0.76
2003 Lee EB, Skovronsky DM, Abtahian F, Doms RW, Lee VM. Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of Biological Chemistry. 278: 4458-66. PMID 12480937 DOI: 10.1074/jbc.M210105200  0.76
2002 Passini MA, Lee EB, Heuer GG, Wolfe JH. Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6437-46. PMID 12151523  0.76
1998 Lindstrom J, Peng X, Kuryatov A, Lee E, Anand R, Gerzanich V, Wang F, Wells G, Nelson M. Molecular and antigenic structure of nicotinic acetylcholine receptors Annals of the New York Academy of Sciences. 841: 71-86. PMID 9668222 DOI: 10.1111/j.1749-6632.1998.tb10910.x  0.76
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