Tom Brown - Publications

Affiliations: 
Yale University, New Haven, CT 

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Jackson MR, Bavelaar BM, Waghorn PA, Gill MR, El-Sagheer AH, Brown T, Tarsounas M, Vallis KA. Radiolabeled oligonucleotides targeting the RNA subunit of telomerase inhibit telomerase and induce DNA damage in telomerase-positive cancer cells. Cancer Research. PMID 31311806 DOI: 10.1158/0008-5472.CAN-18-3594  0.32
2019 Klimkowski P, De Ornellas S, Singleton D, El-Sagheer AH, Brown T. Design of thiazole orange oligonucleotide probes for detection of DNA and RNA by fluorescence and duplex melting. Organic & Biomolecular Chemistry. PMID 31157811 DOI: 10.1039/c9ob00885c  0.32
2019 Thorpe C, Epple S, Woods B, El-Sagheer AH, Brown T. Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications. Organic & Biomolecular Chemistry. PMID 31099373 DOI: 10.1039/c9ob00691e  0.32
2019 Taemaitree L, Shivalingam A, El-Sagheer AH, Brown T. An artificial triazole backbone linkage provides a split-and-click strategy to bioactive chemically modified CRISPR sgRNA. Nature Communications. 10: 1610. PMID 30962447 DOI: 10.1038/s41467-019-09600-4  0.32
2019 De Fazio AF, El-Sagheer AH, Kahn JS, Nandhakumar I, Burton MR, Brown T, Muskens OL, Gang O, Kanaras AG. Light-Induced Reversible DNA Ligation of Gold Nanoparticle Superlattices. Acs Nano. PMID 30958671 DOI: 10.1021/acsnano.9b01294  0.32
2018 Chen J, Baker YR, Brown A, El-Sagheer AH, Brown T. Enzyme-free synthesis of cyclic single-stranded DNA constructs containing a single triazole, amide or phosphoramidate backbone linkage and their use as templates for rolling circle amplification and nanoflower formation. Chemical Science. 9: 8110-8120. PMID 30542561 DOI: 10.1039/c8sc02952k  0.32
2018 Moros M, Kyriazi ME, El-Sagheer AH, Brown T, Tortiglione C, Kanaras AG. DNA-Coated Gold Nanoparticles for the Detection of mRNA in Live Hydra Vulgaris Animals. Acs Applied Materials & Interfaces. PMID 30525369 DOI: 10.1021/acsami.8b17846  0.32
2018 Walsh S, El-Sagheer AH, Brown T. Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above. Chemical Science. 9: 7681-7687. PMID 30393529 DOI: 10.1039/c8sc02418a  0.32
2018 Baker YR, Chen J, Brown J, El-Sagheer AH, Wiseman P, Johnson E, Goddard P, Brown T. Preparation and characterization of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size. Nucleic Acids Research. PMID 30010979 DOI: 10.1093/nar/gky630  0.32
2018 Kumar P, Truong L, Baker YR, El-Sagheer AH, Brown T. Synthesis, Affinity for Complementary RNA and DNA, and Enzymatic Stability of Triazole-Linked Locked Nucleic Acids (t-LNAs). Acs Omega. 3: 6976-6987. PMID 29978149 DOI: 10.1021/acsomega.8b01086  0.32
2018 Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC. Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading. Cell Reports. 23: 3419-3428. PMID 29924986 DOI: 10.1016/j.celrep.2018.05.061  0.32
2018 Giust D, Lucío MI, El-Sagheer AH, Brown T, Williams LE, Muskens OL, Kanaras AG. Graphene Oxide-Upconversion Nanoparticle Based Portable Sensors for Assessing Nutritional Deficiencies in Crops. Acs Nano. PMID 29873479 DOI: 10.1021/acsnano.8b03261  0.32
2018 Bood M, Füchtbauer AF, Wranne MS, Ro JJ, Sarangamath S, El-Sagheer AH, Rupert DLM, Fisher RS, Magennis SW, Jones AC, Höök F, Brown T, Kim BH, Dahlén A, Wilhelmsson LM, et al. Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue. Chemical Science. 9: 3494-3502. PMID 29780479 DOI: 10.1039/c7sc05448c  0.32
2018 Manuguerra I, Croce S, El-Sagheer AH, Krissanaprasit A, Brown T, Gothelf KV, Manetto A. Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures. Chemical Communications (Cambridge, England). PMID 29662975 DOI: 10.1039/c8cc00738a  0.32
2018 Kyriazi ME, Giust D, El-Sagheer AH, Lackie PM, Muskens OL, Brown T, Kanaras AG. Multiplexed mRNA Sensing and Combinatorial-Targeted Drug Delivery Using DNA-Gold Nanoparticle Dimers. Acs Nano. PMID 29557641 DOI: 10.1021/acsnano.7b08620  0.32
2018 Midelet J, El-Sagheer AH, Brown T, Kanaras AG, Débarre A, Werts MHV. Spectroscopic and Hydrodynamic Characterisation of DNA-Linked Gold Nanoparticle Dimers in Solution using Two-Photon Photoluminescence. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. PMID 29465817 DOI: 10.1002/cphc.201701228  0.32
2018 Piccoli J, Hein R, El-Sagheer AH, Brown T, Cilli EM, Bueno PR, Davis JJ. Redox Capacitive Assaying of CRP at a Peptide Supported Aptamer Interface. Analytical Chemistry. PMID 29411973 DOI: 10.1021/acs.analchem.7b05374  0.32
2017 Matysiak S, Hellmuth K, El-Sagheer AH, Shivalingam A, Ariyurek Y, de Jong M, Hollestelle MJ, Out R, Brown T. Searching for avidity by chemical ligation of combinatorially self-assembled DNA-encoded ligand libraries. Organic & Biomolecular Chemistry. PMID 29215120 DOI: 10.1039/c7ob02119d  0.32
2017 Kukwikila M, Gale N, El-Sagheer AH, Brown T, Tavassoli A. Assembly of a biocompatible triazole-linked gene by one-pot click-DNA ligation. Nature Chemistry. 9: 1089-1098. PMID 29064492 DOI: 10.1038/nchem.2850  0.32
2017 El-Sagheer AH, Brown T. Single tube gene synthesis by phosphoramidate chemical ligation. Chemical Communications (Cambridge, England). PMID 28913522 DOI: 10.1039/c7cc00858a  0.32
2017 Kumar P, El-Sagheer AH, Truong L, Brown T. Locked nucleic acid (LNA) enhances binding affinity of triazole-linked DNA towards RNA. Chemical Communications (Cambridge, England). PMID 28748236 DOI: 10.1039/c7cc05159j  0.32
2017 Wang H, Zhang Y, Li R, Nie J, El-Sagheer AH, Brown T, Liu Z, Xiao W. Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments. Chemical Communications (Cambridge, England). PMID 28677697 DOI: 10.1039/c7cc03240d  0.44
2017 Wranne MS, Füchtbauer AF, Dumat B, Bood MSR, El-Sagheer AH, Brown T, Gradén H, Grøtli M, Wilhelmsson LM. Towards complete sequence flexibility of nucleic acid base analogue FRET. Journal of the American Chemical Society. PMID 28613885 DOI: 10.1021/jacs.7b04517  0.32
2017 Abdullah UB, McGouran JF, Brolih S, Ptchelkine D, El-Sagheer AH, Brown T, McHugh PJ. RPA activates the XPF-ERCC1 endonuclease to initiate processing of DNA interstrand crosslinks. The Embo Journal. PMID 28607004 DOI: 10.15252/embj.201796664  0.32
2017 Shivalingam A, Tyburn AE, El-Sagheer AH, Brown T. Molecular Requirements of High-Fidelity Replication-Competent DNA Backbones for Orthogonal Chemical Ligation. Journal of the American Chemical Society. PMID 28097865 DOI: 10.1021/jacs.6b11530  0.32
2016 Heuer-Jungemann A, El-Sagheer AH, Lackie PM, Brown T, Kanaras AG. Selective killing of cells triggered by their mRNA signature in the presence of smart nanoparticles. Nanoscale. 8: 16857-16861. PMID 27714148 DOI: 10.1039/c6nr06154k  0.32
2016 Haugland MM, El-Sagheer AH, Porter RJ, Pena J, Brown T, Anderson EA, Lovett JE. 2'-Alkynylnucleotides: A sequence- and spin label-flexible strategy for EPR spectroscopy in DNA. Journal of the American Chemical Society. PMID 27409454 DOI: 10.1021/jacs.6b05421  0.32
2016 Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, Brown T, Feng JQ, Ke HZ, Bauman WA, Cardozo CP. Sclerostin Antibody Preserves the Morphology and Structure of Osteocytes and Blocks the Severe Skeletal Deterioration After Motor-Complete Spinal Cord Injury in Rats. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 31: 1482. PMID 27377772 DOI: 10.1002/jbmr.2864  0.52
2016 Qiu J, Wilson A, El-Sagheer AH, Brown T. Combination probes with intercalating anchors and proximal fluorophores for DNA and RNA detection. Nucleic Acids Research. PMID 27369379 DOI: 10.1093/nar/gkw579  0.32
2016 Meng W, Muscat RA, McKee ML, Milnes PJ, El-Sagheer AH, Bath J, Davis BG, Brown T, O'Reilly RK, Turberfield AJ. An autonomous molecular assembler for programmable chemical synthesis. Nature Chemistry. 8: 542-548. PMID 27219697 DOI: 10.1038/nchem.2495  0.32
2016 Nie J, Brown T, Zhang Y. New two dimensional liquid-phase colorimetric assay based on old iodine-starch complexation for the naked-eye quantitative detection of analytes. Chemical Communications (Cambridge, England). PMID 27074248 DOI: 10.1039/c6cc01529h  0.44
2016 Ren X, El-Sagheer AH, Brown T. Efficient enzymatic synthesis and dual-colour fluorescent labelling of DNA probes using long chain azido-dUTP and BCN dyes. Nucleic Acids Research. PMID 26819406 DOI: 10.1093/nar/gkw028  0.32
2015 El-Sagheer AH, Brown T. A triazole linkage that mimics the DNA phosphodiester group in living systems. Quarterly Reviews of Biophysics. 48: 429-36. PMID 26537402 DOI: 10.1017/S0033583515000141  0.32
2015 Harimech PK, Gerrard SR, El-Sagheer AH, Brown T, Kanaras AG. Reversible Ligation of Programmed DNA-Gold Nanoparticle Assemblies. Journal of the American Chemical Society. 137: 9242-5. PMID 26192342 DOI: 10.1021/jacs.5b05683  0.32
2015 Qin W, Li X, Peng Y, Harlow LM, Ren Y, Wu Y, Li J, Qin Y, Sun J, Zheng S, Brown T, Feng JQ, Ke HZ, Bauman WA, Cardozo CC. Sclerostin antibody preserves the morphology and structure of osteocytes and blocks the severe skeletal deterioration after motor-complete spinal cord injury in rats. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 25974843 DOI: 10.1002/jbmr.2549  0.52
2015 Ren X, El-Sagheer AH, Brown T. Azide and trans-cyclooctene dUTPs: incorporation into DNA probes and fluorescent click-labelling. The Analyst. 140: 2671-8. PMID 25734317 DOI: 10.1039/c5an00158g  0.32
2014 Davidson KM, Brown TM, James V, Kirk J, Richardson J. Manual-assisted cognitive therapy for self-harm in personality disorder and substance misuse: a feasibility trial. Psychiatric Bulletin (2014). 38: 108-11. PMID 25237519 DOI: 10.1192/pb.bp.113.043109  0.52
2014 Ren X, Gerowska M, El-Sagheer AH, Brown T. Enzymatic incorporation and fluorescent labelling of cyclooctyne-modified deoxyuridine triphosphates in DNA. Bioorganic & Medicinal Chemistry. 22: 4384-90. PMID 24953951 DOI: 10.1016/j.bmc.2014.05.050  0.32
2014 Chen X, El-Sagheer AH, Brown T. Reverse transcription through a bulky triazole linkage in RNA: implications for RNA sequencing. Chemical Communications (Cambridge, England). 50: 7597-600. PMID 24889467 DOI: 10.1039/c4cc03027c  0.32
2014 Bosaeus N, El-Sagheer AH, Brown T, Ã…kerman B, Nordén B. Force-induced melting of DNA--evidence for peeling and internal melting from force spectra on short synthetic duplex sequences. Nucleic Acids Research. 42: 8083-91. PMID 24838568 DOI: 10.1093/nar/gku441  0.32
2014 Birts CN, Sanzone AP, El-Sagheer AH, Blaydes JP, Brown T, Tavassoli A. Transcription of click-linked DNA in human cells. Angewandte Chemie (International Ed. in English). 53: 2362-5. PMID 24452865 DOI: 10.1002/anie.201308691  0.32
2014 Lercher L, McDonough MA, El-Sagheer AH, Thalhammer A, Kriaucionis S, Brown T, Schofield CJ. Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chemical Communications (Cambridge, England). 50: 1794-6. PMID 24287551 DOI: 10.1039/c3cc48151d  0.32
2013 Heuer-Jungemann A, Kirkwood R, El-Sagheer AH, Brown T, Kanaras AG. Copper-free click chemistry as an emerging tool for the programmed ligation of DNA-functionalised gold nanoparticles. Nanoscale. 5: 7209-12. PMID 23828172 DOI: 10.1039/c3nr02362a  0.32
2013 Qiu J, El-Sagheer AH, Brown T. Solid phase click ligation for the synthesis of very long oligonucleotides. Chemical Communications (Cambridge, England). 49: 6959-61. PMID 23814786 DOI: 10.1039/c3cc42451k  0.32
2013 Fonvielle M, Li de La Sierra-Gallay I, El-Sagheer AH, Lecerf M, Patin D, Mellal D, Mayer C, Blanot D, Gale N, Brown T, van Tilbeurgh H, Ethève-Quelquejeu M, Arthur M. The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors. Angewandte Chemie (International Ed. in English). 52: 7278-81. PMID 23744707 DOI: 10.1002/anie.201301411  0.32
2013 Hannestad JK, Brune R, Czolkos I, Jesorka A, El-Sagheer AH, Brown T, Albinsson B, Orwar O. Kinetics of diffusion-mediated DNA hybridization in lipid monolayer films determined by single-molecule fluorescence spectroscopy. Acs Nano. 7: 308-15. PMID 23215045 DOI: 10.1021/nn304010p  0.32
2012 Bosaeus N, El-Sagheer AH, Brown T, Smith SB, Akerman B, Bustamante C, Nordén B. Tension induces a base-paired overstretched DNA conformation. Proceedings of the National Academy of Sciences of the United States of America. 109: 15179-84. PMID 22949705 DOI: 10.1073/pnas.1213172109  0.32
2012 Sanzone AP, El-Sagheer AH, Brown T, Tavassoli A. Assessing the biocompatibility of click-linked DNA in Escherichia coli. Nucleic Acids Research. 40: 10567-75. PMID 22904087 DOI: 10.1093/nar/gks756  0.32
2012 Shelbourne M, Brown T, El-Sagheer AH, Brown T. Fast and efficient DNA crosslinking and multiple orthogonal labelling by copper-free click chemistry. Chemical Communications (Cambridge, England). 48: 11184-6. PMID 22892959 DOI: 10.1039/c2cc35084j  0.32
2012 El-Sagheer AH, Brown T. Click nucleic acid ligation: applications in biology and nanotechnology. Accounts of Chemical Research. 45: 1258-67. PMID 22439702 DOI: 10.1021/ar200321n  0.32
2011 Dallmann A, El-Sagheer AH, Dehmel L, Mügge C, Griesinger C, Ernsting NP, Brown T. Structure and dynamics of triazole-linked DNA: Biocompatibility explained Chemistry - a European Journal. 17: 14714-14717. PMID 22131102 DOI: 10.1002/chem.201102979  0.32
2011 el-Sagheer AH, Brown T. Efficient RNA synthesis by in vitro transcription of a triazole-modified DNA template. Chemical Communications (Cambridge, England). 47: 12057-8. PMID 21961113 DOI: 10.1039/c1cc14316f  0.32
2011 El-Sagheer AH, Sanzone AP, Gao R, Tavassoli A, Brown T. Biocompatible artificial DNA linker that is read through by DNA polymerases and is functional in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 11338-43. PMID 21709264 DOI: 10.1073/pnas.1101519108  0.32
2011 Shelbourne M, Chen X, Brown T, El-Sagheer AH. Fast copper-free click DNA ligation by the ring-strain promoted alkyne-azide cycloaddition reaction. Chemical Communications (Cambridge, England). 47: 6257-9. PMID 21547301 DOI: 10.1039/c1cc10743g  0.32
2011 Thalhammer A, Hansen AS, El-Sagheer AH, Brown T, Schofield CJ. Hydroxylation of methylated CpG dinucleotides reverses stabilisation of DNA duplexes by cytosine 5-methylation. Chemical Communications (Cambridge, England). 47: 5325-7. PMID 21451870 DOI: 10.1039/c0cc05671e  0.32
2011 Dierckx A, Dinér P, El-Sagheer AH, Kumar JD, Brown T, Grøtli M, Wilhelmsson LM. Characterization of photophysical and base-mimicking properties of a novel fluorescent adenine analogue in DNA. Nucleic Acids Research. 39: 4513-24. PMID 21278417 DOI: 10.1093/nar/gkr010  0.32
2011 Hansen AS, Thalhammer A, El-Sagheer AH, Brown T, Schofield CJ. Improved synthesis of 5-hydroxymethyl-2'-deoxycytidine phosphoramidite using a 2'-deoxyuridine to 2'-deoxycytidine conversion without temporary protecting groups. Bioorganic & Medicinal Chemistry Letters. 21: 1181-4. PMID 21256007 DOI: 10.1016/j.bmcl.2010.12.098  0.32
2011 El-Sagheer AH, Cheong VV, Brown T. Rapid chemical ligation of oligonucleotides by the Diels-Alder reaction. Organic & Biomolecular Chemistry. 9: 232-5. PMID 21072410 DOI: 10.1039/c0ob00451k  0.32
2010 Börjesson K, Wiberg J, El-Sagheer AH, Ljungdahl T, Mårtensson J, Brown T, Nordén B, Albinsson B. Functionalized nanostructures: redox-active porphyrin anchors for supramolecular DNA assemblies. Acs Nano. 4: 5037-46. PMID 20809571 DOI: 10.1021/nn100667b  0.32
2010 El-Sagheer AH, Brown T. New strategy for the synthesis of chemically modified RNA constructs exemplified by hairpin and hammerhead ribozymes. Proceedings of the National Academy of Sciences of the United States of America. 107: 15329-34. PMID 20713730 DOI: 10.1073/pnas.1006447107  0.32
2010 Lundberg EP, El-Sagheer AH, Kocalka P, Wilhelmsson LM, Brown T, Nordén B. A new fixation strategy for addressable nano-network building blocks. Chemical Communications (Cambridge, England). 46: 3714-6. PMID 20386862 DOI: 10.1039/c001513j  0.32
2010 El-Sagheer AH, Brown T. Click chemistry with DNA. Chemical Society Reviews. 39: 1388-405. PMID 20309492 DOI: 10.1039/b901971p  0.32
Show low-probability matches.