P. Michael Conn - Publications

Oregon National Primate Research Center, Beaverton, OR, United States 

219 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Janovick JA, Spicer TP, Smith E, Bannister TD, Kenakin T, Scampavia L, Conn PM. Receptor antagonism/agonism can be uncoupled from pharmacoperone activity. Molecular and Cellular Endocrinology. PMID 27389877 DOI: 10.1016/J.Mce.2016.07.003  0.88
2016 Smith E, Janovick JA, Bannister TD, Shumate J, Scampavia L, Conn PM, Spicer TP. Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus. Journal of Biomolecular Screening. PMID 27280550 DOI: 10.1177/1087057116653925  0.72
2016 Ulloa-Aguirre A, Conn PM. Pharmacoperones as a New Therapeutic Approach: In vitro Identification and In vivo Validation of Bioactive Molecules. Current Drug Targets. PMID 26953247  0.36
2015 Conn PM, Spicer TP, Scampavia L, Janovick JA. Assay strategies for identification of therapeutic leads that target protein trafficking. Trends in Pharmacological Sciences. 36: 498-505. PMID 26067100 DOI: 10.1016/j.tips.2015.05.004  0.88
2015 Ulloa-Aguirre A, Zariñán T, Conn PM. Pharmacoperones: targeting therapeutics toward diseases caused by protein misfolding. Revista De InvestigacióN ClíNica; Organo Del Hospital De Enfermedades De La NutricióN. 67: 15-9. PMID 25857579  0.36
2015 Madoux F, Janovick JA, Smithson D, Fargue S, Danpure CJ, Scampavia L, Chen YT, Spicer TP, Conn PM. Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening. Assay and Drug Development Technologies. 13: 16-24. PMID 25710543 DOI: 10.1089/adt.2014.627  0.88
2014 Conn PM, Smith E, Spicer T, Chase P, Scampavia L, Janovick JA. A phenotypic high throughput screening assay for the identification of pharmacoperones for the gonadotropin releasing hormone receptor. Assay and Drug Development Technologies. 12: 238-46. PMID 24831790 DOI: 10.1089/Adt.2014.576  0.88
2014 Wang H, Larson M, Jablonka-Shariff A, Pearl CA, Miller WL, Conn PM, Boime I, Kumar TR. Redirecting intracellular trafficking and the secretion pattern of FSH dramatically enhances ovarian function in mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 5735-40. PMID 24706813 DOI: 10.1073/Pnas.1321404111  0.88
2014 Houck SA, Ren HY, Madden VJ, Bonner JN, Conlin MP, Janovick JA, Conn PM, Cyr DM. Quality control autophagy degrades soluble ERAD-resistant conformers of the misfolded membrane protein GnRHR. Molecular Cell. 54: 166-79. PMID 24685158 DOI: 10.1016/j.molcel.2014.02.025  0.88
2014 Conn PM, Smithson DC, Hodder PS, Stewart MD, Behringer RR, Smith E, Ulloa-Aguirre A, Janovick JA. Transitioning pharmacoperones to therapeutic use: in vivo proof-of-principle and design of high throughput screens. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 83: 38-51. PMID 24373832 DOI: 10.1016/J.Phrs.2013.12.004  0.88
2014 Conn PM, Ulloa-Aguirre A, Janovick JA. "Pharmacoperone": what's in a word? Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 83: 1-2. PMID 24269962 DOI: 10.1016/j.phrs.2013.11.005  0.36
2014 Ulloa-Aguirre A, Zariñán T, Dias JA, Conn PM. Mutations in G protein-coupled receptors that impact receptor trafficking and reproductive function. Molecular and Cellular Endocrinology. 382: 411-23. PMID 23806559 DOI: 10.1016/J.Mce.2013.06.024  0.88
2014 Ulloa-Aguirre A, Conn PM. Intracellular Trafficking of G Protein-Coupled Receptors to the Plasma Membrane in Health and Disease Cellular Endocrinology in Health and Disease. 341-364. DOI: 10.1016/B978-0-12-408134-5.00021-4  0.88
2014 Ulloa-Aguirre A, Conn PM. Cellular Endocrinology in Health and Disease Cellular Endocrinology in Health and Disease. 1-403.  0.88
2014 Cornea A, Conn PM. Fluorescence Microscopy: Super-Resolution and other Novel Techniques Fluorescence Microscopy: Super-Resolution and Other Novel Techniques. 1-249.  0.4
2013 Janovick JA, Stewart MD, Jacob D, Martin LD, Deng JM, Stewart CA, Wang Y, Cornea A, Chavali L, Lopez S, Mitalipov S, Kang E, Lee HS, Manna PR, Stocco DM, ... ... Conn PM, et al. Restoration of testis function in hypogonadotropic hypogonadal mice harboring a misfolded GnRHR mutant by pharmacoperone drug therapy. Proceedings of the National Academy of Sciences of the United States of America. 110: 21030-5. PMID 24324164 DOI: 10.1073/Pnas.1315194110  0.88
2013 Conn PM. Methods in Cell Biology. Receptor-receptor interactions. Preface. Methods in Cell Biology. 117: xxi-xxii. PMID 24143993 DOI: 10.1016/B978-0-12-408143-7.10000-3  0.88
2013 Cabrera-Wrooman A, Janovick JA, Conn PM. Species sequence differences determine the interaction of GnRH receptor with the cellular quality control system. Molecular and Cellular Endocrinology. 381: 1-7. PMID 23891857 DOI: 10.1016/J.Mce.2013.07.012  0.88
2013 Conn PM, Smith E, Hodder P, Janovick JA, Smithson DC. High-throughput screen for pharmacoperones of the vasopressin type 2 receptor. Journal of Biomolecular Screening. 18: 930-7. PMID 23640875 DOI: 10.1177/1087057113483559  0.88
2013 Conn PM. Methods in Enzymology. G protein coupled receptors trafficking and oligomerization. Preface. Methods in Enzymology. 521: xix. PMID 23351751 DOI: 10.1016/B978-0-12-391862-8.10000-6  0.88
2013 Smithson DC, Janovick JA, Conn PM. Therapeutic rescue of misfolded/mistrafficked mutants: automation-friendly high-throughput assays for identification of pharmacoperone drugs of GPCRs. Methods in Enzymology. 521: 3-16. PMID 23351731 DOI: 10.1016/B978-0-12-391862-8.00001-6  0.88
2013 Conn PM. Preface. Methods in Enzymology. 520: xvii. PMID 23332709 DOI: 10.1016/B978-0-12-391861-1.10000-0  0.88
2013 Conn PM. Preface: Laboratory methods in cell biology. Methods in Cell Biology. 113: xv. PMID 23317913 DOI: 10.1016/B978-0-12-407239-8.22001-6  0.88
2013 Dancet EA, Brännström M, Brasky K, Chai D, Chan AW, Conn PM, Else J, Falconer H, Fazleabas AT, Farah IO, Goddeeris BM, Golos TG, Hau J, Hearn JP, Kariuki TM, et al. The role of scientists and clinicians in raising public support for animal research in reproductive biology and medicine. Biology of Reproduction. 88: 33. PMID 23255340 DOI: 10.1095/Biolreprod.112.105908  0.88
2013 Conn PM. Animal Models for the Study of Human Disease Animal Models For the Study of Human Disease. 1-1089.  0.88
2012 Aguilar-Rojas A, Huerta-Reyes M, Maya-Núñez G, Arechavaleta-Velásco F, Conn PM, Ulloa-Aguirre A, Valdés J. Gonadotropin-releasing hormone receptor activates GTPase RhoA and inhibits cell invasion in the breast cancer cell line MDA-MB-231. Bmc Cancer. 12: 550. PMID 23176180 DOI: 10.1186/1471-2407-12-550  0.88
2012 Maya-Núñez G, Ulloa-Aguirre A, Janovick JA, Conn PM. Pharmacological chaperones correct misfolded GPCRs and rescue function: protein trafficking as a therapeutic target. Sub-Cellular Biochemistry. 63: 263-89. PMID 23161143 DOI: 10.1007/978-94-007-4765-4_14  0.88
2012 Stewart MD, Deng JM, Stewart CA, Mullen RD, Wang Y, Lopez S, Serna MK, Huang CC, Janovick JA, Pask AJ, Schwartz RJ, Conn PM, Behringer RR. Mice harboring Gnrhr E90K, a mutation that causes protein misfolding and hypogonadotropic hypogonadism in humans, exhibit testis size reduction and ovulation failure. Molecular Endocrinology (Baltimore, Md.). 26: 1847-56. PMID 22918878 DOI: 10.1210/Me.2012-1072  0.72
2012 Janovick JA, Pogozheva ID, Mosberg HI, Cornea A, Conn PM. Rescue of misrouted GnRHR mutants reveals its constitutive activity. Molecular Endocrinology (Baltimore, Md.). 26: 1179-88. PMID 22595961 DOI: 10.1210/Me.2012-1089  0.72
2012 Conn PM. Methods in Enzymology. Preface. Methods in Enzymology. 506: xxi. PMID 22341239 DOI: 10.1016/B978-0-12-391856-7.00055-X  0.88
2012 Conn PM. Preface. Methods in Enzymology. 505: xix. PMID 22289469 DOI: 10.1016/B978-0-12-388448-0.00008-5  0.88
2011 Ulloa-Aguirre A, Conn PM. Pharmacoperones: A new therapeutic approach for diseases caused by misfolded G protein-coupled receptors Recent Patents On Endocrine, Metabolic and Immune Drug Discovery. 5: 13-24. PMID 22074574 DOI: 10.2174/187221411794351851  0.88
2011 Conn PM, Ulloa-Aguirre A. Pharmacological chaperones for misfolded gonadotropin-releasing hormone receptors. Advances in Pharmacology (San Diego, Calif.). 62: 109-41. PMID 21907908 DOI: 10.1016/B978-0-12-385952-5.00008-7  0.88
2011 Janovick JA, Park BS, Conn PM. Therapeutic rescue of misfolded mutants: validation of primary high throughput screens for identification of pharmacoperone drugs. Plos One. 6: e22784. PMID 21818389 DOI: 10.1371/journal.pone.0022784  0.88
2011 Conn PM, Janovick JA. Pharmacoperone identification for therapeutic rescue of misfolded mutant proteins. Frontiers in Endocrinology. 2. PMID 21633718 DOI: 10.3389/fendo.2011.00006  0.72
2011 Janovick JA, Pogozheva ID, Mosberg HI, Conn PM. Salt bridges overlapping the gonadotropin-releasing hormone receptor agonist binding site reveal a coincidence detector for G protein-coupled receptor activation. The Journal of Pharmacology and Experimental Therapeutics. 338: 430-42. PMID 21527534 DOI: 10.1124/Jpet.111.180869  0.88
2011 Conn PM. The unfolded protein response and cellular stress, Part C. Preface. Methods in Enzymology. 491: xix. PMID 21329790 DOI: 10.1016/B978-0-12-385928-0.00028-6  0.88
2011 Maya-Núñez G, Janovick JA, Aguilar-Rojas A, Jardón-Valadez E, Leaños-Miranda A, Zariñan T, Ulloa-Aguirre A, Conn PM. Biochemical mechanism of pathogenesis of human gonadotropin-releasing hormone receptor mutants Thr104Ile and Tyr108Cys associated with familial hypogonadotropic hypogonadism. Molecular and Cellular Endocrinology. 337: 16-23. PMID 21277937 DOI: 10.1016/j.mce.2011.01.016  0.88
2011 Conn PM. Methods in Enzymology. Preface. Methods in Enzymology. 490: xvii. PMID 21266240 DOI: 10.1016/B978-0-12-385114-7.00020-9  0.88
2011 Conn PM. The unfolded protein response and cellular stress, Part A.. Preface. Methods in Enzymology. 489: xvii. PMID 21266220 DOI: 10.1016/B978-0-12-385116-1.00020-0  0.88
2011 Mungall CJ, Anderson D, Bandrowski A, Canada B, Chatyr-Aryamontri A, Cheng K, Conn PM, Dolinski K, Ellisman M, Eppig J, Grethe JS, Kemnitz J, Iadonato S, Larson SD, Magness C, et al. An ontology-based approach to linking model organisms and resources to human diseases Ceur Workshop Proceedings. 833: 263-265.  0.88
2011 Parker JV, Conn PM. From test tube to hypodermic needle: A prescription for educating the public on the value of using animals in medical research Scientist. 25.  0.88
2010 Janovick JA, Conn PM. Use of pharmacoperones to reveal GPCR structural changes associated with constitutive activation and trafficking. Methods in Enzymology. 485: 277-92. PMID 21050923 DOI: 10.1016/B978-0-12-381296-4.00016-6  0.72
2010 Conn PM. Methods to assess the mechanism of protein function. Preface. Methods in Enzymology. 484: xxv. PMID 21036223 DOI: 10.1016/B978-0-12-381298-8.00041-1  0.88
2010 Re M, Pampillo M, Savard M, Dubuc C, McArdle CA, Millar RP, Conn PM, Gobeil F, Bhattacharya M, Babwah AV. The human gonadotropin releasing hormone type I receptor is a functional intracellular GPCR expressed on the nuclear membrane. Plos One. 5: e11489. PMID 20628612 DOI: 10.1371/Journal.Pone.0011489  0.88
2010 Zariñán T, Perez-Solís MA, Maya-Núñez G, Casas-González P, Conn PM, Dias JA, Ulloa-Aguirre A. Dominant negative effects of human follicle-stimulating hormone receptor expression-deficient mutants on wild-type receptor cell surface expression. Rescue of oligomerization-dependent defective receptor expression by using cognate decoys. Molecular and Cellular Endocrinology. 321: 112-22. PMID 20206665 DOI: 10.1016/J.Mce.2010.02.027  0.88
2010 Janovick JA, Conn PM. Salt bridge integrates GPCR activation with protein trafficking. Proceedings of the National Academy of Sciences of the United States of America. 107: 4454-8. PMID 20160100 DOI: 10.1073/pnas.0914261107  0.88
2010 Conn PM, Rantin FT. Ethical research as the target of animal extremism: an international problem. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 43: 124-6. PMID 20098845  0.88
2010 Ayala Yáñez R, Conn PM. Protein disulfide isomerase chaperone ERP-57 decreases plasma membrane expression of the human GnRH receptor. Cell Biochemistry and Function. 28: 66-73. PMID 20029959 DOI: 10.1002/cbf.1622  0.88
2010 Conn PM, Ulloa-Aguirre A. Trafficking of G-protein-coupled receptors to the plasma membrane: insights for pharmacoperone drugs. Trends in Endocrinology and Metabolism: Tem. 21: 190-7. PMID 20005736 DOI: 10.1016/j.tem.2009.11.003  0.88
2010 Jennes L, Ulloa-Aguirre A, Janovick JA, Adjan VV, Conn PM. The gonadotropin-releasing hormone and its receptor Hormones, Brain and Behavior Online. 1645-1669. DOI: 10.1016/B978-008088783-8.00051-6  0.88
2009 Conn PM, Janovick JA. Drug development and the cellular quality control system. Trends in Pharmacological Sciences. 30: 228-33. PMID 19307028 DOI: 10.1016/J.Tips.2009.02.002  0.88
2009 Lucca-Junior W, Janovick JA, Conn PM. Participation of the endoplasmic reticulum protein chaperone thio-oxidoreductase in gonadotropin-releasing hormone receptor expression at the plasma membrane. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 42: 164-7. PMID 19274343  0.88
2009 Ulloa-Aguirre A, Conn PM. Targeting of G protein-coupled receptors to the plasma membrane in health and disease. Frontiers in Bioscience (Landmark Edition). 14: 973-94. PMID 19273112 DOI: 10.2741/3290  0.88
2009 Jardón-Valadez E, Aguilar-Rojas A, Maya-Núñez G, Leaños-Miranda A, Piñeiro A, Conn PM, Ulloa-Aguirre A. Conformational effects of Lys191 in the human GnRH receptor: mutagenesis and molecular dynamics simulations studies. The Journal of Endocrinology. 201: 297-307. PMID 19246515 DOI: 10.1677/JOE-08-0527  0.88
2009 Janovick JA, Patny A, Mosley R, Goulet MT, Altman MD, Rush TS, Cornea A, Conn PM. Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor. Molecular Endocrinology (Baltimore, Md.). 23: 157-68. PMID 19095769 DOI: 10.1210/Me.2008-0384  0.72
2009 Conn PM, Janovick JA. Trafficking and quality control of the gonadotropin releasing hormone receptor in health and disease. Molecular and Cellular Endocrinology. 299: 137-45. PMID 19059461 DOI: 10.1016/J.Mce.2008.10.051  0.88
2009 Janovick JA, Maya-Núñez G, Ulloa-Aguirre A, Huhtaniemi IT, Dias JA, Verbost P, Conn PM. Increased plasma membrane expression of human follicle-stimulating hormone receptor by a small molecule thienopyr(im)idine. Molecular and Cellular Endocrinology. 298: 84-8. PMID 18848862 DOI: 10.1016/J.Mce.2008.09.015  0.88
2009 Conn PM. A legal challenge to animal research Scientist. 23.  0.88
2008 Conn PM, Parker JV. Physiologists embedded in the animal research war. The Physiologist. 51: 85, 94-5. PMID 18595298  0.88
2008 Knollman PE, Conn PM. Multiple G proteins compete for binding with the human gonadotropin releasing hormone receptor. Archives of Biochemistry and Biophysics. 477: 92-7. PMID 18541137 DOI: 10.1016/j.abb.2008.05.011  0.88
2008 Conn PM, Parker JV. The animal research war. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1294-5. PMID 18450645 DOI: 10.1096/fj.08-0502ufm  0.88
2008 Conn PM. Source book of models for biomedical research Source Book of Models For Biomedical Research. 1-778. DOI: 10.1007/978-1-59745-285-4  0.88
2008 Conn PM, Parker JV. Winners and losers in the animal-research war American Scientist. 96: 184-186.  0.88
2008 Conn PM. The war on animal research Scientist. 22: 40-46.  0.88
2007 Conn PM, Ulloa-Aguirre A, Ito J, Janovick JA. G protein-coupled receptor trafficking in health and disease: lessons learned to prepare for therapeutic mutant rescue in vivo. Pharmacological Reviews. 59: 225-50. PMID 17878512 DOI: 10.1124/pr.59.3.2  0.88
2007 Janovick JA, Brothers SP, Cornea A, Bush E, Goulet MT, Ashton WT, Sauer DR, Haviv F, Greer J, Conn PM. Refolding of misfolded mutant GPCR: post-translational pharmacoperone action in vitro. Molecular and Cellular Endocrinology. 272: 77-85. PMID 17555869 DOI: 10.1016/j.mce.2007.04.012  0.72
2007 Samant MP, White R, Hong DJ, Croston G, Conn PM, Janovick JA, Rivier J. Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives. Journal of Medicinal Chemistry. 50: 2067-77. PMID 17402723 DOI: 10.1021/jm0613931  0.88
2007 Janovick JA, Brothers SP, Knollman PE, Conn PM. Specializations of a G-protein-coupled receptor that appear to aid with detection of frequency-modulated signals from its ligand. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 384-92. PMID 17172315 DOI: 10.1096/fj.06-6901com  0.88
2006 Brothers SP, Janovick JA, Conn PM. Calnexin regulated gonadotropin-releasing hormone receptor plasma membrane expression. Journal of Molecular Endocrinology. 37: 479-88. PMID 17170088 DOI: 10.1677/jme.1.02142  0.88
2006 Ulloa-Aguirre A, Janovick JA, Miranda AL, Conn PM. G-protein-coupled receptor trafficking: understanding the chemical basis of health and disease. Acs Chemical Biology. 1: 631-8. PMID 17168568 DOI: 10.1021/cb600360h  0.88
2006 Conn PM, Janovick JA, Brothers SP, Knollman PE. 'Effective inefficiency': cellular control of protein trafficking as a mechanism of post-translational regulation. The Journal of Endocrinology. 190: 13-6. PMID 16837606 DOI: 10.1677/joe.1.06771  0.88
2006 Leaños-Miranda A, Ulloa-Aguirre A, Cervini LA, Janovick JA, Rivier J, Conn PM. Identification of new gonadotrophin-releasing hormone partial agonists. The Journal of Endocrinology. 189: 509-17. PMID 16731782 DOI: 10.1677/joe.1.06724  0.88
2006 Conn PM, Knollman PE, Brothers SP, Janovick JA. Protein folding as posttranslational regulation: evolution of a mechanism for controlled plasma membrane expression of a G protein-coupled receptor. Molecular Endocrinology (Baltimore, Md.). 20: 3035-41. PMID 16556733 DOI: 10.1210/me.2006-0066  0.88
2006 Janovick JA, Knollman PE, Brothers SP, Ayala-Yáñez R, Aziz AS, Conn PM. Regulation of G protein-coupled receptor trafficking by inefficient plasma membrane expression: molecular basis of an evolved strategy. The Journal of Biological Chemistry. 281: 8417-25. PMID 16446355 DOI: 10.1074/jbc.M510601200  0.88
2006 Conn PM. Handbook of Models for Human Aging Handbook of Models For Human Aging 0.88
2005 Knollman PE, Janovick JA, Brothers SP, Conn PM. Parallel regulation of membrane trafficking and dominant-negative effects by misrouted gonadotropin-releasing hormone receptor mutants. The Journal of Biological Chemistry. 280: 24506-14. PMID 15886197 DOI: 10.1074/jbc.M501978200  0.88
2005 Leaños-Miranda A, Ulloa-Aguirre A, Janovick JA, Conn PM. In vitro coexpression and pharmacological rescue of mutant gonadotropin-releasing hormone receptors causing hypogonadotropic hypogonadism in humans expressing compound heterozygous alleles. The Journal of Clinical Endocrinology and Metabolism. 90: 3001-8. PMID 15728205 DOI: 10.1210/jc.2004-2071  0.88
2005 Pask AJ, Kanasaki H, Kaiser UB, Conn PM, Janovick JA, Stockton DW, Hess DL, Justice MJ, Behringer RR. A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation. Molecular Endocrinology (Baltimore, Md.). 19: 972-81. PMID 15625238 DOI: 10.1210/Me.2004-0192  0.88
2005 Castro-Fernández C, Maya-Núñez G, Conn PM. Beyond the signal sequence: protein routing in health and disease. Endocrine Reviews. 26: 479-503. PMID 15536207 DOI: 10.1210/er.2004-0010  0.88
2005 Conn PM, Janovick JA. A new understanding of protein mutation unfolds American Scientist. 93: 314-321. DOI: 10.1511/2005.4.314  0.88
2005 Conn PM. Introduction to endocrinology Endocrinology: Basic and Clinical Principles: Second Edition. 3-5. DOI: 10.1007/978-1-59259-829-8_1  0.88
2005 Melmed S, Conn PM. Endocrinology: Basic and clinical principles: Second edition Endocrinology: Basic and Clinical Principles: Second Edition. 1-440. DOI: 10.1007/978-1-59259-829-8  0.88
2004 Ulloa-Aguirre A, Janovick JA, Brothers SP, Conn PM. Pharmacologic rescue of conformationally-defective proteins: implications for the treatment of human disease. Traffic (Copenhagen, Denmark). 5: 821-37. PMID 15479448 DOI: 10.1111/j.1600-0854.2004.00232.x  0.88
2004 Washington TM, Blum JJ, Reed MC, Conn PM. A mathematical model for LH release in response to continuous and pulsatile exposure of gonadotrophs to GnRH. Theoretical Biology & Medical Modelling. 1: 9. PMID 15447787 DOI: 10.1186/1742-4682-1-9  0.88
2004 Timossi C, Ortiz-Elizondo C, Pineda DB, Dias JA, Conn PM, Ulloa-Aguirre A. Functional significance of the BBXXB motif reversed present in the cytoplasmic domains of the human follicle-stimulating hormone receptor. Molecular and Cellular Endocrinology. 223: 17-26. PMID 15279907 DOI: 10.1016/J.Mce.2004.06.004  0.88
2004 Meysing AU, Kanasaki H, Bedecarrats GY, Acierno JS, Conn PM, Martin KA, Seminara SB, Hall JE, Crowley WF, Kaiser UB. GNRHR mutations in a woman with idiopathic hypogonadotropic hypogonadism highlight the differential sensitivity of luteinizing hormone and follicle-stimulating hormone to gonadotropin-releasing hormone. The Journal of Clinical Endocrinology and Metabolism. 89: 3189-98. PMID 15240592 DOI: 10.1210/Jc.2003-031808  0.88
2004 Brothers SP, Cornea A, Janovick JA, Conn PM. Human loss-of-function gonadotropin-releasing hormone receptor mutants retain wild-type receptors in the endoplasmic reticulum: molecular basis of the dominant-negative effect. Molecular Endocrinology (Baltimore, Md.). 18: 1787-97. PMID 15105440 DOI: 10.1210/me.2004-0091  0.88
2004 Ulloa-Aguirre A, Janovick JA, Leaños-Miranda A, Conn PM. Misrouted cell surface GnRH receptors as a disease aetiology for congenital isolated hypogonadotrophic hypogonadism. Human Reproduction Update. 10: 177-92. PMID 15073146 DOI: 10.1093/humupd/dmh015  0.88
2004 Conn PM. Imaging in biological research part B: Preface Methods in Enzymology. 386: xi. DOI: 10.1016/S0076-6879(04)86021-X  0.88
2004 Conn PM. Imaging in biological research: Part A - Preface Methods in Enzymology. 385: xiii. DOI: 10.1016/S0076-6879(04)85023-7  0.88
2003 Janovick JA, Ulloa-Aguirre A, Conn PM. Evolved regulation of gonadotropin-releasing hormone receptor cell surface expression. Endocrine. 22: 317-27. PMID 14709805 DOI: 10.1385/ENDO:22:3:317  0.88
2003 Brothers SP, Janovick JA, Conn PM. Unexpected effects of epitope and chimeric tags on gonadotropin-releasing hormone receptors: implications for understanding the molecular etiology of hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 88: 6107-12. PMID 14671217 DOI: 10.1210/Jc.2003-031047  0.88
2003 Kumar TR, Agno J, Janovick JA, Conn PM, Matzuk MM. Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice. Molecular and Cellular Endocrinology. 212: 19-27. PMID 14654247 DOI: 10.1016/J.Mce.2003.09.019  0.88
2003 Bédécarrats GY, Linher KD, Janovick JA, Beranova M, Kada F, Seminara SB, Michael Conn P, Kaiser UB. Four naturally occurring mutations in the human GnRH receptor affect ligand binding and receptor function. Molecular and Cellular Endocrinology. 205: 51-64. PMID 12890567 DOI: 10.1016/S0303-7207(03)00201-6  0.88
2003 Leaños-Miranda A, Ulloa-Aguirre A, Ji TH, Janovick JA, Conn PM. Dominant-negative action of disease-causing gonadotropin-releasing hormone receptor (GnRHR) mutants: a trait that potentially coevolved with decreased plasma membrane expression of GnRHR in humans. The Journal of Clinical Endocrinology and Metabolism. 88: 3360-7. PMID 12843188 DOI: 10.1210/jc.2003-030084  0.88
2003 Ulloa-Aguirre A, Janovick JA, Leaños-Miranda A, Conn PM. Misrouted cell surface receptors as a novel disease aetiology and potential therapeutic target: the case of hypogonadotropic hypogonadism due to gonadotropin-releasing hormone resistance. Expert Opinion On Therapeutic Targets. 7: 175-85. PMID 12667096 DOI: 10.1517/14728222.7.2.175  0.72
2003 Castro-Fernández C, Brothers SP, Michael Conn P. A Galphas mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T. Molecular and Cellular Endocrinology. 200: 119-26. PMID 12644305 DOI: 10.1016/S0303-7207(02)00378-7  0.68
2003 Maya-Núñez G, Conn PM. Transcriptional regulation of the GnRH receptor gene by glucocorticoids. Molecular and Cellular Endocrinology. 200: 89-98. PMID 12644302 DOI: 10.1016/S0303-7207(02)00419-7  0.88
2003 Janovick JA, Goulet M, Bush E, Greer J, Wettlaufer DG, Conn PM. Structure-activity relations of successful pharmacologic chaperones for rescue of naturally occurring and manufactured mutants of the gonadotropin-releasing hormone receptor. The Journal of Pharmacology and Experimental Therapeutics. 305: 608-14. PMID 12606630 DOI: 10.1124/jpet.102.048454  0.88
2003 Hirshberg B, Conn PM, Uwaifo GI, Blauer KL, Clark BD, Nieman LK. Ectopic luteinizing hormone secretion and anovulation. The New England Journal of Medicine. 348: 312-7. PMID 12540644 DOI: 10.1056/NEJMoa022384  0.88
2003 Castro-Fernández C, Brothers SP, Conn PM. A Gαs mutation (D229S) differentially effects gonadotropin-releasing hormone receptor regulation by RGS10, RGS3 and RGS3T Molecular and Cellular Endocrinology. 200: 119-126. DOI: 10.1016/S0303-7207(02)00378-7  0.88
2002 Conn PM, Leaños-Miranda A, Janovick JA. Protein origami: therapeutic rescue of misfolded gene products. Molecular Interventions. 2: 308-16. PMID 14993385 DOI: 10.1124/mi.2.5.308  0.88
2002 Leaños-Miranda A, Janovick JA, Conn PM. Receptor-misrouting: an unexpectedly prevalent and rescuable etiology in gonadotropin-releasing hormone receptor-mediated hypogonadotropic hypogonadism. The Journal of Clinical Endocrinology and Metabolism. 87: 4825-8. PMID 12364481 DOI: 10.1210/Jc.2002-020961  0.72
2002 Cornea A, Conn PM. Measurement of changes in fluorescence resonance energy transfer between gonadotropin-releasing hormone receptors in response to agonists. Methods (San Diego, Calif.). 27: 333-9. PMID 12217649  0.4
2002 Janovick JA, Maya-Nunez G, Conn PM. Rescue of hypogonadotropic hypogonadism-causing and manufactured GnRH receptor mutants by a specific protein-folding template: misrouted proteins as a novel disease etiology and therapeutic target. The Journal of Clinical Endocrinology and Metabolism. 87: 3255-62. PMID 12107234 DOI: 10.1210/jcem.87.7.8582  0.88
2002 Castro-Fernández C, Conn PM. Regulation of the gonadotropin-releasing hormone receptor (GnRHR) by RGS proteins: role of the GnRHR carboxyl-terminus. Molecular and Cellular Endocrinology. 191: 149-56. PMID 12062898 DOI: 10.1016/S0303-7207(02)00082-5  0.88
2002 Timossi C, Maldonado D, Vizcaíno A, Lindau-Shepard B, Conn PM, Ulloa-Aguirre A. Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation. Molecular and Cellular Endocrinology. 189: 157-68. PMID 12039074  0.36
2002 Brothers SP, Janovick JA, Maya-Nunez G, Cornea A, Han XB, Conn PM. Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization. Molecular and Cellular Endocrinology. 190: 19-27. PMID 11997175 DOI: 10.1016/S0303-7207(02)00040-0  0.88
2002 Maya-Núñez G, Janovick JA, Ulloa-Aguirre A, Söderlund D, Conn PM, Méndez JP. Molecular basis of hypogonadotropic hypogonadism: restoration of mutant (E(90)K) GnRH receptor function by a deletion at a distant site. The Journal of Clinical Endocrinology and Metabolism. 87: 2144-9. PMID 11994356 DOI: 10.1210/jcem.87.5.8386  0.72
2002 Castro-Fernández C, Janovick JA, Brothers SP, Fisher RA, Ji TH, Conn PM. Regulation of RGS3 and RGS10 palmitoylation by GnRH. Endocrinology. 143: 1310-7. PMID 11897687 DOI: 10.1210/Endo.143.4.8713  0.32
2002 Conn PM. Laser capture microscopy: Preface Methods in Enzymology. 356: xiii. DOI: 10.1016/S0076-6879(02)56916-0  0.88
2001 Maya-Núñez G, Conn PM. Cyclic adenosine 3',5'-monophosphate (cAMP) and cAMP responsive element-binding protein are involved in the transcriptional regulation of gonadotropin-releasing hormone (GnRH) receptor by GnRH and mitogen-activated protein kinase signal transduction pathway in GGH(3) cells. Biology of Reproduction. 65: 561-7. PMID 11466226  0.88
2001 Cornea A, Janovick JA, Maya-Núñez G, Conn PM. Gonadotropin-releasing hormone receptor microaggregation. Rate monitored by fluorescence resonance energy transfer. The Journal of Biological Chemistry. 276: 2153-8. PMID 11035030 DOI: 10.1074/jbc.M007850200  0.88
2000 Maya-Núñez G, Janovick JA, Conn PM. Combined modification of intracellular and extracellular loci on human gonadotropin-releasing hormone receptor provides a mechanism for enhanced expression. Endocrine. 13: 401-7. PMID 11216654 DOI: 10.1385/ENDO:13:3:401  0.88
2000 Frohman LA, Kineman RD, Kamegai J, Park S, Teixeira LT, Coschigano KT, Kopchick JJ, Mayo K, Hock J, Conn PM. Secretagogues and the somatotrope: Signaling and proliferation Recent Progress in Hormone Research. 55: 269-291. PMID 11036941  0.88
2000 Lin J, Toft DJ, Bengtson NW, Linzer DIH, Conn PM, Kochupillai N, Cidlowski J, Lawrence A. Placental prolactins and the physiology of pregnancy Recent Progress in Hormone Research. 55: 37-52. PMID 11036932  0.88
2000 Lin X, Janovick JA, Cardenas R, Conn PM, Peter RE. Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary. Molecular and Cellular Endocrinology. 166: 75-87. PMID 10996426 DOI: 10.1016/S0303-7207(00)00278-1  0.88
2000 Timossi CM, Barrios-de-Tomasi J, González-Suárez R, Arranz MC, Padmanabhan V, Conn PM, Ulloa-Aguirre A. Differential effects of the charge variants of human follicle-stimulating hormone. The Journal of Endocrinology. 165: 193-205. PMID 10810283 DOI: 10.1677/Joe.0.1650193  0.88
2000 Blum JJ, Reed MC, Janovick JA, Conn PM. A mathematical model quantifying GnRH-induced LH secretion from gonadotropes. American Journal of Physiology. Endocrinology and Metabolism. 278: E263-72. PMID 10662710  0.88
2000 Kubli-Garfias C, Conn PM. Electronic structure of gonadotropin-releasing hormone (GnRH): A semiempirical study Journal of Molecular Structure: Theochem. 529: 203-208. DOI: 10.1016/S0166-1280(00)00547-9  0.88
2000 Conn PM. Recent progress in hormone research: Preface Recent Progress in Hormone Research. 55: ix.  0.88
1999 Pinter JH, Janovick JA, Conn PM. Gonadotropin-releasing hormone receptor concentration differentially regulates intracellular signaling pathways in GGH3 cells. Pituitary. 2: 181-90. PMID 11081152  0.88
1999 Ulloa-Aguirre A, Stanislaus D, Janovick JA, Conn PM. Structure-activity relationships of G protein-coupled receptors. Archives of Medical Research. 30: 420-35. PMID 10714355 DOI: 10.1016/S0188-0128(99)00041-X  0.88
1999 Lin X, Janovick JA, Brothers S, Conn PM, Peter RE. Molecular cloning and expression of two type one somatostatin receptors in goldfish brain. Endocrinology. 140: 5211-9. PMID 10537151 DOI: 10.1210/endo.140.11.7094  0.88
1999 Cornea A, Janovick JA, Lin X, Conn PM. Simultaneous and independent visualization of the gonadotropin-releasing hormone receptor and its ligand: evidence for independent processing and recycling in living cells. Endocrinology. 140: 4272-80. PMID 10465301 DOI: 10.1210/endo.140.9.7049  0.88
1999 Maya-Núñez G, Conn PM. Transcriptional regulation of the gonadotropin-releasing hormone receptor gene is mediated in part by a putative repressor element and by the cyclic adenosine 3',5'-monophosphate response element. Endocrinology. 140: 3452-8. PMID 10433200 DOI: 10.1210/endo.140.8.6945  0.88
1999 Han XB, Conn PM. The role of protein kinases A and C pathways in the regulation of mitogen-activated protein kinase activation in response to gonadotropin-releasing hormone receptor activation. Endocrinology. 140: 2241-51. PMID 10218977 DOI: 10.1210/endo.140.5.6707  0.88
1999 Lin X, Conn PM. Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH: involvement of multiple signal transduction pathways. Endocrinology. 140: 358-64. PMID 9886846 DOI: 10.1210/endo.140.1.6452  0.88
1999 Ulloa-Aguirre A, Conn PM. Archives of Medical Research: Preface Archives of Medical Research. 30: 419. DOI: 10.1016/S0188-0128(99)00055-X  0.88
1999 Conn PM. Methods in enzymology: Preface Methods in Enzymology. 307: xiii. DOI: 10.1016/S0076-6879(99)07001-9  0.88
1999 Conn PM. Recent Progress in Hormone Research: Proceedings of the 1998 Conference: Preface Recent Progress in Hormone Research. 54: x.  0.88
1999 Conn PM. Green Flourescent Protein: Preface Methods in Enzymology. 302: xiii.  0.88
1998 Lin X, Cornea A, Janovick JA, Conn PM. Visualization of unoccupied and occupied gonadotropin-releasing hormone receptors in living cells. Molecular and Cellular Endocrinology. 146: 27-37. PMID 10022760 DOI: 10.1016/S0303-7207(98)00204-4  0.88
1998 Conn PM, Parker J. Animal rights: reaching the public. Science (New York, N.Y.). 282: 1417. PMID 9867643  0.88
1998 Stanislaus D, Pinter JH, Janovick JA, Conn PM. Mechanisms mediating multiple physiological responses to gonadotropin-releasing hormone. Molecular and Cellular Endocrinology. 144: 1-10. PMID 9863622 DOI: 10.1016/S0303-7207(98)00126-9  0.88
1998 Lin X, Janovick JA, Conn PM. Mutations at the consensus phosphorylation sites in the third intracellular loop of the rat gonadotropin-releasing hormone receptor: effects on receptor ligand binding and signal transduction. Biology of Reproduction. 59: 1470-6. PMID 9828194  0.88
1998 Lin X, Conn PM. Transcriptional activation of gonadotropin-releasing hormone (GnRH) receptor gene by GnRH and cyclic adenosine monophosphate. Endocrinology. 139: 3896-902. PMID 9724045 DOI: 10.1210/endo.139.9.6214  0.88
1998 Stanislaus D, Ponder S, Ji TH, Conn PM. Gonadotropin-releasing hormone receptor couples to multiple G proteins in rat gonadotrophs and in GGH3 cells: evidence from palmitoylation and overexpression of G proteins. Biology of Reproduction. 59: 579-86. PMID 9716556 DOI: 10.1095/BIOLREPROD59.3.579  0.88
1998 Stanislaus D, Janovick JA, Ji T, Wilkie TM, Offermanns S, Conn PM. Gonadotropin and gonadal steroid release in response to a gonadotropin-releasing hormone agonist in Gqalpha and G11alpha knockout mice. Endocrinology. 139: 2710-7. PMID 9607776 DOI: 10.1210/endo.139.6.5942  0.88
1998 Ulloa-Aguirre A, Stanislaus D, Arora V, Väänänen J, Brothers S, Janovick JA, Conn PM. The third intracellular loop of the rat gonadotropin-releasing hormone receptor couples the receptor to Gs- and G(q/11)-mediated signal transduction pathways: evidence from loop fragment transfection in GGH3 cells. Endocrinology. 139: 2472-8. PMID 9564860 DOI: 10.1210/endo.139.5.6022  0.88
1998 Lin X, Janovick JA, Brothers S, Blömenrohr M, Bogerd J, Conn PM. Addition of catfish gonadotropin-releasing hormone (GnRH) receptor intracellular carboxyl-terminal tail to rat GnRH receptor alters receptor expression and regulation. Molecular Endocrinology (Baltimore, Md.). 12: 161-71. PMID 9482659 DOI: 10.1210/mend.12.2.0056  0.88
1998 Cornea A, Janovick JA, Stanislaus D, Conn PM. Redistribution of G(q/11)alpha in the pituitary gonadotrope in response to a gonadotropin-releasing hormone agonist. Endocrinology. 139: 397-402. PMID 9421439 DOI: 10.1210/endo.139.1.5687  0.72
1998 Conn PM. Ion channels. Part C: Preface Methods in Enzymology. 294: xv. DOI: 10.1016/S0076-6879(99)94002-8  0.88
1997 Jennes L, Eyigor O, Janovick JA, Conn PM. Brain gonadotropin releasing hormone receptors: localization and regulation. Recent Progress in Hormone Research. 52: 475-90; discussion 4. PMID 9238864  0.88
1997 Stanislaus D, Janovick JA, Brothers S, Conn PM. Regulation of G(q/11)alpha by the gonadotropin-releasing hormone receptor. Molecular Endocrinology (Baltimore, Md.). 11: 738-46. PMID 9171237 DOI: 10.1210/mend.11.6.0005  0.88
1997 Kaiser UB, Conn PM, Chin WW. Studies of gonadotropin-releasing hormone (GnRH) action using GnRH receptor-expressing pituitary cell lines. Endocrine Reviews. 18: 46-70. PMID 9034786 DOI: 10.1210/Edrv.18.1.0289  0.88
1997 Grunfeld C, Papadakis M, Conn PM, Bowers CY. Growth hormone research and therapy [7] Science. 275: 465. PMID 9019805  0.88
1996 Akita S, Conn PM, Melmed S. Leukemia inhibitory factor (LIF) induces acute adrenocorticotrophic hormone (ACTH) secretion in fetal rhesus macaque primates: a novel dynamic test of pituitary function. The Journal of Clinical Endocrinology and Metabolism. 81: 4170-8. PMID 8923879 DOI: 10.1210/jcem.81.11.8923879  0.88
1996 Pralong FP, Boepple PA, Conn PM, Whitcomb RW, Butler JP, Schoenfeld D, Crowley WF. Contour of the GnRH pulse independently modulates gonadotropin secretion in the human male. Neuroendocrinology. 64: 247-56. PMID 8875443 DOI: 10.1159/000127125  0.88
1996 Janovick JA, Conn PM. Gonadotropin releasing hormone agonist provokes homologous receptor microaggregation: an early event in seven-transmembrane receptor mediated signaling. Endocrinology. 137: 3602-5. PMID 8754794 DOI: 10.1210/endo.137.8.8754794  0.88
1996 Conn PM, Bowers CY. A new receptor for growth hormone-release peptide. Science (New York, N.Y.). 273: 923. PMID 8711477  0.88
1996 Janovick JA, Conn PM. Progesterone diminishes the sensitivity of gonadotropin-releasing hormone-stimulated luteinizing hormone (LH) release and protects an LH pool from desensitization: actions opposed by cholera toxin. Endocrinology. 137: 1823-7. PMID 8612520 DOI: 10.1210/endo.137.5.8612520  0.88
1996 Stanislaus D, Arora V, Awara WM, Conn PM. Biphasic action of cyclic adenosine 3',5'- monophosphate in gonadotropin-releasing hormone (GnRH) analog-stimulated hormone release from GH3 cells stably transfected with GnRH receptor complementary deoxyribonucleic acid. Endocrinology. 137: 1025-31. PMID 8603570 DOI: 10.1210/endo.137.3.8603570  0.88
1996 Awara WM, Guo CH, Conn PM. Effects of Asn318 and Asp87Asn318 mutations on signal transduction by the gonadotropin-releasing hormone receptor and receptor regulation. Endocrinology. 137: 655-62. PMID 8593815 DOI: 10.1210/endo.137.2.8593815  0.88
1995 Jennes L, Brame B, Centers A, Janovick JA, Conn PM. Regulation of hippocampal gonadotropin releasing hormone (GnRH) receptor mRNA and GnRH-stimulated inositol phosphate production by gonadal steroid hormones. Brain Research. Molecular Brain Research. 33: 104-10. PMID 8774951  0.72
1995 Kaiser UB, Sabbagh E, Katzenellenbogen RA, Conn PM, Chin WW. A mechanism for the differential regulation of gonadotropin subunit gene expression by gonadotropin-releasing hormone. Proceedings of the National Academy of Sciences of the United States of America. 92: 12280-4. PMID 8618885 DOI: 10.1073/Pnas.92.26.12280  0.88
1995 Janovick JA, Jennes L, Conn PM. GH3 cells transfected with gonadotropin-releasing hormone (GnRH) receptor complementary deoxyribonucleic acid release secretogranin-II through a constitutive pathway after GnRH analog-regulated synthesis: evidence that secretory proteins do not contain a sequence that obligates processing through a secretory granule or by regulated secretion. Endocrinology. 136: 202-8. PMID 7828532 DOI: 10.1210/endo.136.1.7828532  0.88
1995 Guo CH, Janovick JA, Kuphal D, Conn PM. Transient transfection of GGH3-1' cells [GH3 cells stably transfected with the gonadotropin-releasing hormone (GnRH) receptor complementary deoxyribonucleic acid] with the carboxyl-terminal of beta-adrenergic receptor kinase 1 blocks prolactin release: evidence for a role of the G protein beta gamma-subunit complex in GnRH signal transduction. Endocrinology. 136: 3031-6. PMID 7789329 DOI: 10.1210/endo.136.7.7789329  0.88
1995 Conn PM, Janovick JA, Stanislaus D, Kuphal D, Jennes L. Molecular and cellular bases of gonadotropin-releasing hormone action in the pituitary and central nervous system. Vitamins and Hormones. 50: 151-214. PMID 7709600  0.88
1994 Fraser HM, Recio R, Conn PM, Lunn SF. Gonadotropin-releasing hormone antagonist for postpartum contraception: outcome for the mother and male offspring in the marmoset. The Journal of Clinical Endocrinology and Metabolism. 78: 121-5. PMID 8288695 DOI: 10.1210/jcem.78.1.8288695  0.88
1994 Katayama T, Conn PM. Activin modulates the intracellular signaling system activated by gonadotropin-releasing hormone: dual effect on calcium messenger system and protein kinase-C pathway. Endocrinology. 134: 119-25. PMID 8275926 DOI: 10.1210/endo.134.1.8275926  0.88
1994 Conn PM, Crowley WF. Gonadotropin-releasing hormone and its analogs. Annual Review of Medicine. 45: 391-405. PMID 8198390 DOI: 10.1146/annurev.med.45.1.391  0.88
1994 Connor JP, Buller RE, Conn PM. Effects of GnRH analogs on six ovarian cancer cell lines in culture. Gynecologic Oncology. 54: 80-6. PMID 8020844 DOI: 10.1006/gyno.1994.1170  0.88
1994 Kuphal D, Janovick JA, Kaiser UB, Chin WW, Conn PM. Stable transfection of GH3 cells with rat gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid results in expression of a receptor coupled to cyclic adenosine 3',5'-monophosphate-dependent prolactin release via a G-protein. Endocrinology. 135: 315-20. PMID 8013367 DOI: 10.1210/Endo.135.1.8013367  0.88
1994 Jennes L, Conn PM. Gonadotropin-releasing hormone and its receptors in rat brain. Frontiers in Neuroendocrinology. 15: 51-77. PMID 7958169 DOI: 10.1006/frne.1994.1003  0.88
1994 Stanislaus D, Janovick JA, Jennes L, Kaiser UB, Chin WW, Conn PM. Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid. Endocrinology. 135: 2220-7. PMID 7956945 DOI: 10.1210/Endo.135.5.7956945  0.88
1994 Janovick JA, Conn PM. Gonadotropin-releasing hormone (GnRH)-receptor coupling to inositol phosphate and prolactin production in GH3 cells stably transfected with rat GnRH receptor complementary deoxyribonucleic acid. Endocrinology. 135: 2214-9. PMID 7956944 DOI: 10.1210/endo.135.5.7956944  0.88
1994 Kaiser UB, Katzenellenbogen RA, Conn PM, Chin WW. Evidence that signalling pathways by which thyrotropin-releasing hormone and gonadotropin-releasing hormone act are both common and distinct. Molecular Endocrinology (Baltimore, Md.). 8: 1038-48. PMID 7527898 DOI: 10.1210/Mend.8.8.7527898  0.88
1993 Bagatell CJ, Conn PM, Bremner WJ. Single-dose administration of the gonadotropin-releasing hormone antagonist, Nal-Lys (antide) to healthy men. Fertility and Sterility. 60: 680-5. PMID 8405525 DOI: 10.1016/S0015-0282(16)56222-0  0.88
1993 Janovick JA, Haviv F, Fitzpatrick TD, Conn PM. Differential orientation of a GnRH agonist and antagonist in the pituitary GnRH receptor. Endocrinology. 133: 942-5. PMID 8393780 DOI: 10.1210/endo.133.2.8393780  0.88
1993 Janovick JA, Conn PM. A cholera toxin-sensitive guanyl nucleotide binding protein mediates the movement of pituitary luteinizing hormone into a releasable pool: loss of this event is associated with the onset of homologous desensitization to gonadotropin-releasing hormone. Endocrinology. 132: 2131-5. PMID 8386609 DOI: 10.1210/endo.132.5.8386609  0.88
1993 Hawes BE, Barnes S, Conn PM. Cholera toxin and pertussis toxin provoke differential effects on luteinizing hormone release, inositol phosphate production, and gonadotropin-releasing hormone (GnRH) receptor binding in the gonadotrope: evidence for multiple guanyl nucleotide binding proteins in GnRH action. Endocrinology. 132: 2124-30. PMID 8386608 DOI: 10.1210/endo.132.5.8386608  0.88
1993 Katayama T, Conn PM. Modulation of activin A action and specificity in the rat gonadotrope by protein kinase C. Endocrinology. 133: 496-504. PMID 8344195 DOI: 10.1210/endo.133.2.8344195  0.88
1993 Barnes SJ, Conn PM. Cholera toxin and dibutyryl cyclic adenosine 3',5'-monophosphate sensitize gonadotropin-releasing hormone-stimulated inositol phosphate production to inhibition in protein kinase-C (PKC)-depleted cells: evidence for cross-talk between a cholera toxin-sensitive G-protein and PKC. Endocrinology. 133: 2756-60. PMID 8243300 DOI: 10.1210/endo.133.6.8243300  0.88
1992 Hawes BE, Waters SB, Janovick JA, Bleasdale JE, Conn PM. Gonadotropin-releasing hormone-stimulated intracellular Ca2+ fluctuations and luteinizing hormone release can be uncoupled from inositol phosphate production. Endocrinology. 130: 3475-83. PMID 1597151 DOI: 10.1210/endo.130.6.1597151  0.88
1992 Conn PM, Janovick JA, Braden TD, Maurer RA, Jennes L. SIIp: a unique secretogranin/chromogranin of the pituitary released in response to gonadotropin-releasing hormone. Endocrinology. 130: 3033-40. PMID 1572311 DOI: 10.1210/endo.130.5.1572311  0.88
1992 Cook JS, Doty KL, Conn PM, Hansen JR. Assessment of depot leuprolide acetate dose-adequacy for central precocious puberty. The Journal of Clinical Endocrinology and Metabolism. 74: 1206-9. PMID 1569169 DOI: 10.1210/jcem.74.5.1569169  0.88
1992 Waters SB, Conn PM. Maintenance of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone release despite desensitization of GnRH-stimulated cytosolic calcium responses. Endocrinology. 130: 2091-100. PMID 1547730 DOI: 10.1210/endo.130.4.1547730  0.88
1992 Hawes BE, Conn PM. Development of gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and recovery are not coupled to inositol phosphate production or GnRH receptor number. Endocrinology. 131: 2681-9. PMID 1332845 DOI: 10.1210/endo.131.6.1332845  0.88
1992 Conn PM, Hawes BE, Janovick JA. Selection of models for the study of GnRH stimulated gonadotropin release prejudices the assignment of roles for mediators and modulators of hormone action. Molecular and Cellular Endocrinology. 84: C33-7. PMID 1316852 DOI: 10.1016/0303-7207(92)90025-2  0.88
1992 Hawes BE, Marzen JE, Waters SB, Conn PM. Sodium fluoride provokes gonadotrope desensitization to gonadotropin-releasing hormone (GnRH) and gonadotrope sensitization to A23187: evidence for multiple G proteins in GnRH action. Endocrinology. 130: 2465-75. PMID 1315244 DOI: 10.1210/endo.130.5.1315244  0.88
1992 Braden TD, Conn PM. Activin-A stimulates the synthesis of gonadotropin-releasing hormone receptors. Endocrinology. 130: 2101-5. PMID 1312442 DOI: 10.1210/endo.130.4.1312442  0.88
1991 Braden TD, Conn PM. The 1990 James A. F. Stevenson Memorial Lecture. Gonadotropin-releasing hormone and its actions. Canadian Journal of Physiology and Pharmacology. 69: 445-58. PMID 2059907  0.88
1991 Conn PM, Crowley WF. Gonadotropin-releasing hormone and its analogues. The New England Journal of Medicine. 324: 93-103. PMID 1984190 DOI: 10.1056/NEJM199101103240205  0.88
1991 Gordon K, Williams RF, Danforth DR, Conn PM, Hutchison JS, Hodgen GD. Suppression of ovarian estradiol secretion by a single injection of antide in cynomolgus monkeys during the early follicular phase: immediate, sustained, and reversible actions. The Journal of Clinical Endocrinology and Metabolism. 73: 1262-8. PMID 1955507 DOI: 10.1210/jcem-73-6-1262  0.88
1991 Waters SB, Conn PM. Regulation of the pituitary gonadotrope by gonadotropin-releasing hormone: multiple intracellular effectors. The Chinese Journal of Physiology. 34: 1-26. PMID 1908369  0.88
1991 Janovick JA, Natarajan K, Longo F, Conn PM. Caldesmon: a bifunctional (calmodulin and actin) binding protein which regulates stimulated gonadotropin release. Endocrinology. 129: 68-74. PMID 1905232 DOI: 10.1210/endo-129-1-68  0.88
1991 Kennealey GT, Milsted RAV, Crowley WF, Conn PM. Gonadotropin-releasing hormone and its analogues [5] New England Journal of Medicine. 325: 520. PMID 1852189  0.88
1991 Natarajan K, Ness J, Wooge CH, Janovick JA, Conn PM. Specific identification and subcellular localization of three calmodulin-binding proteins in the rat gonadotrope: spectrin, caldesmon, and calcineurin. Biology of Reproduction. 44: 43-52. PMID 1849752 DOI: 10.1095/biolreprod44.1.43  0.88
1991 Braden TD, Bervig T, Conn PM. Protein kinase-C activation stimulates synthesis of gonadotropin-releasing hormone (GnRH) receptors, but does not mediate GnRH-stimulated receptor synthesis. Endocrinology. 129: 2486-90. PMID 1657576 DOI: 10.1210/endo-129-5-2486  0.88
1991 Conn PM. Letter to the readers Endocrinology. 129: 1.  0.88
1990 Jennes L, Janovick J, Braden T, Conn PM. Gonadotropin releasing hormone binding sites in rat hippocampus: Different structure/binding relationships compared to the anterior pituitary. Molecular and Cellular Neurosciences. 1: 121-7. PMID 19912761 DOI: 10.1016/1044-7431(90)90015-V  0.88
1990 Andrews WV, Hansen JR, Janovick JA, Conn PM. Gonadotropin-releasing hormone modulation of protein kinase-C activity in perifused anterior pituitary cell cultures. Endocrinology. 127: 2393-9. PMID 2171914 DOI: 10.1210/endo-127-5-2393  0.72
1990 Braden TD, Farnworth PG, Burger HG, Conn PM. Regulation of the synthetic rate of gonadotropin-releasing hormone receptors in rat pituitary cell cultures by inhibin. Endocrinology. 127: 2387-92. PMID 2171913 DOI: 10.1210/endo-127-5-2387  0.88
1990 Braden TD, Conn PM. Altered rate of synthesis of gonadotropin-releasing hormone receptors: effects of homologous hormone appear independent of extracellular calcium. Endocrinology. 126: 2577-82. PMID 2158430 DOI: 10.1210/endo-126-5-2577  0.88
1989 Braden TD, Hawes BE, Conn PM. Synthesis of gonadotropin-releasing hormone receptors by gonadotrope cell cultures: both preexisting receptors and those unmasked by protein kinase-C activators show a similar synthetic rate. Endocrinology. 125: 1623-9. PMID 2547592 DOI: 10.1210/endo-125-3-1623  0.88
1988 Valadez FJ, Staley D, Conn PM. Release of gonadotropin alpha subunit from rat pituitary cultures in response to GnRH. Molecular and Cellular Endocrinology. 56: 81-9. PMID 3286323 DOI: 10.1016/0303-7207(88)90011-1  0.88
1988 Dodson WC, Myers T, Morton PC, Conn PM. Leuprolide acetate: serum and follicular fluid concentrations and effects on human fertilization, embryo growth, and granulosa-lutein cell progesterone accumulation in vitro. Fertility and Sterility. 50: 612-7. PMID 3139466  0.88
1987 Handwerger S, Wilson SP, Tyrey L, Conn PM. Biochemical evidence that human placental lactogen and human chorionic gonadotropin are not stored in cytoplasmic secretion granules. Biology of Reproduction. 37: 28-32. PMID 3651549  0.88
1987 Goldman JM, Cooper RL, Rehnberg GL, Gabel S, McElroy WK, Hein J, Conn PM. Age-related alterations in the stimulated release in vitro of catecholamines and luteinizing hormone-releasing hormone from the male rat hypothalamus. Neurochemical Research. 12: 651-7. PMID 3302741 DOI: 10.1007/BF00971015  0.88
1987 Conn PM, Staley DD, Yasumoto T, Huckle WR, Janovick JA. Homologous desensitization with gonadotropin-releasing hormone (GnRH) also diminishes gonadotrope responsiveness to maitotoxin: a role for the GnRH receptor-regulated calcium ion channel in mediation of cellular desensitization. Molecular Endocrinology (Baltimore, Md.). 1: 154-9. PMID 2457798 DOI: 10.1210/mend-1-2-154  0.88
1986 Andrews WV, Staley DD, Huckle WR, Conn PM. Stimulation of luteinizing hormone (LH) release and phospholipid breakdown by guanosine triphosphate in permeabilized pituitary gonadotropes: antagonist action suggests association of a G protein and gonadotropin-releasing hormone receptor. Endocrinology. 119: 2537-46. PMID 3023016 DOI: 10.1210/endo-119-6-2537  0.88
1986 Ojeda SR, Urbanski HF, Katz KH, Costa ME, Conn PM. Activation of two different but complementary biochemical pathways stimulates release of hypothalamic luteinizing hormone-releasing hormone. Proceedings of the National Academy of Sciences of the United States of America. 83: 4932-6. PMID 3014521  0.88
1986 Conn PM, Staley D, Harris C, Andrews WV, Gorospe WC, McArdle CA, Huckle WR, Hansen J. Mechanism of action of gonadotropin releasing hormone. Annual Review of Physiology. 48: 495-513. PMID 3010823 DOI: 10.1146/annurev.ph.48.030186.002431  0.88
1985 Clapper DL, Conn PM. Gonadotropin-releasing hormone stimulation of pituitary gonadotrope cells produces an increase in intracellular calcium. Biology of Reproduction. 32: 269-78. PMID 3921069  0.88
1985 Harris CE, Staley D, Conn PM. Diacylglycerols and protein kinase C. Potential amplifying mechanism for Ca2+-mediated gonadotropin-releasing hormone-stimulated luteinizing hormone release. Molecular Pharmacology. 27: 532-6. PMID 3157862  0.88
1985 Conn PM, Ganong BR, Ebeling J, Staley D, Neidel JE, Bell RM. Diacylglycerols release LH: structure-activity relations reveal a role for protein kinase C. Biochemical and Biophysical Research Communications. 126: 532-9. PMID 3155946 DOI: 10.1016/0006-291X(85)90638-2  0.88
1985 Conn PM, Staley D, Jinnah H, Bates M. Molecular mechanism of gonadotropin releasing hormone action. Journal of Steroid Biochemistry. 23: 703-10. PMID 3001414 DOI: 10.1016/S0022-4731(85)80005-4  0.88
1985 Jennes L, Bronson D, Stumpf WE, Conn PM. Evidence for an association between calmodulin and membrane patches containing gonadotropin-releasing hormone--receptor complexes in cultured gonadotropes. Cell and Tissue Research. 239: 311-5. PMID 2983896 DOI: 10.1007/BF00218009  0.88
1984 Handwerger S, Wilson S, Conn PM. Different subcellular storage sites for decidual- and pituitary-derived prolactin: possible explanation for differences in regulation. Molecular and Cellular Endocrinology. 37: 83-7. PMID 6468751 DOI: 10.1016/0303-7207(84)90130-8  0.88
1984 Conn PM, Rogers DC, Seay SG, Staley D. Activation of luteinizing hormone release from pituitary cells by polycations. Endocrinology. 115: 1913-7. PMID 6386445 DOI: 10.1210/endo-115-5-1913  0.88
1984 Bates MD, Conn PM. Calcium mobilization in the pituitary gonadotrope: relative roles of intra- and extracellular sources. Endocrinology. 115: 1380-5. PMID 6383788 DOI: 10.1210/endo-115-4-1380  0.88
1983 Smith WA, Conn PM. GnRH-mediated desensitization of the pituitary gonadotrope is not calcium dependent. Endocrinology. 112: 408-10. PMID 6401180 DOI: 10.1210/endo-112-1-408  0.88
1982 Conn PM, Rogers DC, McNeil R. Potency enhancement of a GnRH agonist: GnRH-receptor microaggregation stimulates gonadotropin release. Endocrinology. 111: 335-7. PMID 6282571 DOI: 10.1210/endo-111-1-335  0.88
1981 Marian J, Cooper RL, Conn PM. Regulation of the rat pituitary gonadotropin-releasing hormone receptor. Molecular Pharmacology. 19: 399-405. PMID 6267446  0.88
1980 Conn PM, Cooper R, McNamara C, Rogers DC, Shoenhardt L. Qualitative change in gonadotropin during normal aging in the male rat. Endocrinology. 106: 1549-53. PMID 7363862 DOI: 10.1210/endo-106-5-1549  0.88
1980 Conn PM, Whorton R, Lazar J. An inhibitor of arachidonic acid metabolism stimulates luteinizing hormone (LH) release from cultured pituitary cells. Prostaglandins. 19: 873-9. PMID 6770421 DOI: 10.1016/0090-6980(80)90121-5  0.88
1980 Conn PM, Kilpatrick D, Kirshner N. Ionophoretic Ca2+ mobilization in rat gonadotropes and bovine adrenomedullary cells Cell Calcium. 1: 129-133. DOI: 10.1016/0143-4160(80)90026-3  0.88
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