Claes Wahlestedt - Publications

Affiliations: 
Neuroscience Scripps Florida, Jupiter, FL, United States 

208 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Lohse I, Al-Ali H, Volmar CH, D Alvarez Trotta A, Brothers SP, Capobianco AJ, Wahlestedt C. Ex vivo drug sensitivity testing as a means for drug repurposing in esophageal adenocarcinoma. Plos One. 13: e0203173. PMID 30212533 DOI: 10.1371/journal.pone.0203173  1
2018 Johnstone AL, O'Reilly JJ, Patel AJ, Guo Z, Andrade NS, Magistri M, Nathanson L, Esanov R, Miller BH, Turecki G, Brothers SP, Zeier Z, Wahlestedt C. Enhancer of Zeste 1 is an antipsychotic-sensitive epigenetic modulator of social and motivational behavior that is dysregulated in schizophrenia. Neurobiology of Disease. PMID 30099093 DOI: 10.1016/j.nbd.2018.08.005  1
2018 Zhu W, Wang H, Wei J, Sartor GC, Bao MM, Pierce CT, Wahlestedt CR, Dykxhoorn DM, Dong C. Cocaine Exposure Increases Blood Pressure and Aortic Stiffness via the miR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway. Hypertension (Dallas, Tex. : 1979). PMID 29483230 DOI: 10.1161/HYPERTENSIONAHA.117.10213  0.36
2017 Mustafi S, Camarena V, Volmar CH, Huff TC, Sant DW, Brothers SP, Liu ZJ, Wahlestedt C, Wang G. Vitamin C sensitizes melanoma to BET inhibitors. Cancer Research. PMID 29180474 DOI: 10.1158/0008-5472.CAN-17-2040  1
2017 Swords RT, Azzam D, Al-Ali H, Lohse I, Volmar CH, Watts JM, Perez A, Rodriguez A, Vargas F, Elias R, Vega F, Zelent A, Brothers SP, Abbasi T, Trent J, ... ... Wahlestedt C, et al. Ex-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study. Leukemia Research. 64: 34-41. PMID 29175379 DOI: 10.1016/j.leukres.2017.11.008  1
2017 Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, ... Wahlestedt C, et al. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. Proceedings of the National Academy of Sciences of the United States of America. 114: E9135-E9144. PMID 29073110 DOI: 10.1073/pnas.1707544114  1
2017 Sartor GC, Powell SK, Velmeshev D, Lin DY, Magistri M, Wiedner HJ, Malvezzi AM, Andrade NS, Faghihi MA, Wahlestedt C. Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. Molecular and Cellular Neurosciences. PMID 29055697 DOI: 10.1016/j.mcn.2017.10.003  0.4
2016 Magistri M, Velmeshev D, Makhmutova M, Patel P, Sartor GC, Volmar CH, Wahlestedt C, Faghihi MA. The BET-bromodomain inhibitor JQ1 reduces inflammation and tau phosphorylation at Ser396 in the brain of the 3xTg model of Alzheimer's disease. Current Alzheimer Research. PMID 27117003  0.4
2016 Peschansky VJ, Pastori C, Zeier Z, Wentzel K, Velmeshev D, Magistri M, Silva JP, Wahlestedt C. The long non-coding RNA FMR4 promotes proliferation of human neural precursor cells and epigenetic regulation of gene expression in trans. Molecular and Cellular Neurosciences. PMID 27001315 DOI: 10.1016/j.mcn.2016.03.008  1
2016 Hossein-Nezhad A, Fatemi RP, Ahmad R, Peskind E, Zabeitian C, Hu SC, Shi M, Wahlestedt C, Zhang J, Faghihi MA. Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Diseases. Journal of Parkinson's Disease. PMID 26889637 DOI: 10.3233/JPD-150737  0.4
2016 Volmar CH, Wahlestedt C, Brothers SP. Orphan diseases: state of the drug discovery art. Wiener Medizinische Wochenschrift (1946). PMID 26819216 DOI: 10.1007/s10354-015-0423-0  1
2015 Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Experimental Neurology. PMID 26746986 DOI: 10.1016/j.expneurol.2015.12.022  1
2015 Sartor GC, Powell SK, Wiedner HJ, Wahlestedt C, Brothers SP. "Nociceptin receptor activation does not alter acquisition, expression, extinction and reinstatement of conditioned cocaine preference in mice". Brain Research. PMID 26657743 DOI: 10.1016/j.brainres.2015.11.044  1
2015 Sartor GC, Powell SK, Brothers SP, Wahlestedt C. Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15062-72. PMID 26558777 DOI: 10.1523/JNEUROSCI.0826-15.2015  1
2015 Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells. Frontiers in Genetics. 6: 263. PMID 26322075 DOI: 10.3389/fgene.2015.00263  0.36
2015 Pedram Fatemi R, Salah-Uddin S, Modarresi F, Khoury N, Wahlestedt C, Faghihi MA. Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. Journal of Biomolecular Screening. 20: 1132-41. PMID 26173710 DOI: 10.1177/1087057115594187  1
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, ... Wahlestedt C, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS. Experimental Neurology. 271: 241-50. PMID 26099177 DOI: 10.1016/j.expneurol.2015.06.017  1
2015 Gidlöf O, Sathanoori R, Magistri M, Faghihi MA, Wahlestedt C, Olde B, Erlinge D. Extracellular Uridine Triphosphate and Adenosine Triphosphate Attenuate Endothelial Inflammation through miR-22-Mediated ICAM-1 Inhibition. Journal of Vascular Research. 52: 71-80. PMID 26088024 DOI: 10.1159/000431367  1
2015 Yamanaka Y, Faghihi MA, Magistri M, Alvarez-Garcia O, Lotz M, Wahlestedt C. Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2. Cell Reports. 11: 967-76. PMID 25937287 DOI: 10.1016/j.celrep.2015.04.011  1
2015 St Laurent G, Wahlestedt C, Kapranov P. The Landscape of long noncoding RNA classification. Trends in Genetics : Tig. 31: 239-51. PMID 25869999 DOI: 10.1016/j.tig.2015.03.007  1
2015 Volmar CH, Wahlestedt C. Histone deacetylases (HDACs) and brain function Neuroepigenetics. 1: 20-27. DOI: 1016/j.nepig.2014.10.002  1
2015 Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C. Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells Frontiers in Genetics. 6. DOI: 10.3389/fgene.2015.00263  1
2015 Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, Laurent GS, Ayad NG, Wahlestedt C, Roberts TC. The bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation Proceedings of the National Academy of Sciences of the United States of America. 112: 8326-8331. DOI: 10.1073/pnas.1424220112  1
2015 Zeier Z, Esanov R, Belle KC, Volmar CH, Johnstone AL, Halley P, DeRosa BA, Khoury N, van Blitterswijk M, Rademakers R, Albert J, Brothers SP, Wuu J, Dykxhoorn DM, Benatar M, ... Wahlestedt C, et al. Bromodomain inhibitors regulate the C9ORF72 locus in ALS Experimental Neurology. 271: 241-250. DOI: 10.1016/j.expneurol.2015.06.017  1
2015 Khorkova O, Hsiao J, Wahlestedt C. Basic biology and therapeutic implications of lncRNA Advanced Drug Delivery Reviews. 87: 15-24. DOI: 10.1016/j.addr.2015.05.012  1
2014 Khomtchouk BB, Van Booven DJ, Wahlestedt C. HeatmapGenerator: high performance RNAseq and microarray visualization software suite to examine differential gene expression levels using an R and C++ hybrid computational pipeline. Source Code For Biology and Medicine. 9: 30. PMID 25550709 DOI: 10.1186/s13029-014-0030-2  1
2014 Long J, Li B, Rodriguez-Blanco J, Pastori C, Volmar CH, Wahlestedt C, Capobianco A, Bai F, Pei XH, Ayad NG, Robbins DJ. The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers. The Journal of Biological Chemistry. 289: 35494-502. PMID 25355313 DOI: 10.1074/jbc.M114.595348  1
2014 Carlsson SK, Brothers SP, Wahlestedt C. Emerging treatment strategies for glioblastoma multiforme. Embo Molecular Medicine. 6: 1359-70. PMID 25312641 DOI: 10.15252/emmm.201302627  1
2014 Plotkin A, Volmar CH, Wahlestedt C, Ayad N, El-Ashry D. Transcriptional repression of ER through hMAPK dependent histone deacetylation by class I HDACs. Breast Cancer Research and Treatment. 147: 249-63. PMID 25129342 DOI: 10.1007/s10549-014-3093-5  1
2014 Barrett E, Brothers S, Wahlestedt C, Beurel E. I-BET151 selectively regulates IL-6 production. Biochimica Et Biophysica Acta. 1842: 1549-55. PMID 24859008 DOI: 10.1016/j.bbadis.2014.05.013  1
2014 Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, et al. HuD regulates coding and noncoding RNA to induce APP→Aβ processing. Cell Reports. 7: 1401-9. PMID 24857657 DOI: 10.1016/j.celrep.2014.04.050  1
2014 Khorkova O, Myers AJ, Hsiao J, Wahlestedt C. Natural antisense transcripts. Human Molecular Genetics. 23: R54-63. PMID 24838284 DOI: 10.1093/hmg/ddu207  1
2014 Peschansky VJ, Wahlestedt C. Non-coding RNAs as direct and indirect modulators of epigenetic regulation. Epigenetics : Official Journal of the Dna Methylation Society. 9: 3-12. PMID 24739571 DOI: 10.4161/epi.27473  1
2014 Pastori C, Daniel M, Penas C, Volmar CH, Johnstone AL, Brothers SP, Graham RM, Allen B, Sarkaria JN, Komotar RJ, Wahlestedt C, Ayad NG. BET bromodomain proteins are required for glioblastoma cell proliferation. Epigenetics : Official Journal of the Dna Methylation Society. 9: 611-20. PMID 24496381 DOI: 10.4161/epi.27906  1
2014 Halley P, Kadakkuzha BM, Faghihi MA, Magistri M, Zeier Z, Khorkova O, Coito C, Hsiao J, Lawrence M, Wahlestedt C. Regulation of the apolipoprotein gene cluster by a long noncoding RNA. Cell Reports. 6: 222-30. PMID 24388749 DOI: 10.1016/j.celrep.2013.12.015  1
2014 Pastori C, Peschansky VJ, Barbouth D, Mehta A, Silva JP, Wahlestedt C. Comprehensive analysis of the transcriptional landscape of the human FMR1 gene reveals two new long noncoding RNAs differentially expressed in Fragile X syndrome and Fragile X-associated tremor/ataxia syndrome. Human Genetics. 133: 59-67. PMID 24005575 DOI: 10.1007/s00439-013-1356-6  1
2013 Halley P, Khorkova O, Wahlestedt C. Natural antisense transcripts as therapeutic targets. Drug Discovery Today. Therapeutic Strategies. 10: e119-e125. PMID 25580147 DOI: 10.1016/j.ddstr.2013.03.001  1
2013 Clarke J, Penas C, Pastori C, Komotar RJ, Bregy A, Shah AH, Wahlestedt C, Ayad NG. Epigenetic pathways and glioblastoma treatment. Epigenetics : Official Journal of the Dna Methylation Society. 8: 785-95. PMID 23807265 DOI: 10.4161/epi.25440  1
2013 Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Science Translational Medicine. 5: 188ra73. PMID 23740899 DOI: 10.1126/scitranslmed.3005656  1
2013 Wahlestedt C. Targeting long non-coding RNA to therapeutically upregulate gene expression. Nature Reviews. Drug Discovery. 12: 433-46. PMID 23722346 DOI: 10.1038/nrd4018  1
2013 Ozomaro U, Wahlestedt C, Nemeroff CB. Personalized medicine in psychiatry: problems and promises. Bmc Medicine. 11: 132. PMID 23680237 DOI: 10.1186/1741-7015-11-132  1
2013 Gidlöf O, van der Brug M, Ohman J, Gilje P, Olde B, Wahlestedt C, Erlinge D. Platelets activated during myocardial infarction release functional miRNA, which can be taken up by endothelial cells and regulate ICAM1 expression. Blood. 121: 3908-17, S1-26. PMID 23493781 DOI: 10.1182/blood-2012-10-461798  1
2012 Peschansky VJ, Liang Z, Wahlestedt C. RNAi joins the "Singles Club". Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 2010-1. PMID 23131851 DOI: 10.1038/mt.2012.218  1
2012 St Laurent G, Shtokalo D, Tackett MR, Yang Z, Eremina T, Wahlestedt C, Urcuqui-Inchima S, Seilheimer B, McCaffrey TA, Kapranov P. Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells. Bmc Genomics. 13: 504. PMID 23006825 DOI: 10.1186/1471-2164-13-504  1
2012 Sartor GC, St Laurent G, Wahlestedt C. The Emerging Role of Non-Coding RNAs in Drug Addiction. Frontiers in Genetics. 3: 106. PMID 22737160 DOI: 10.3389/fgene.2012.00106  1
2012 Pastori C, Wahlestedt C. Involvement of long noncoding RNAs in diseases affecting the central nervous system. Rna Biology. 9: 860-70. PMID 22699553 DOI: 10.4161/rna.20482  1
2012 Mittapalli GK, Vellucci D, Yang J, Toussaint M, Brothers SP, Wahlestedt C, Roberts E. Synthesis and SAR of selective small molecule neuropeptide Y Y2 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 22: 3916-20. PMID 22607676 DOI: 10.1016/j.bmcl.2012.04.107  1
2012 Magistri M, Faghihi MA, St Laurent G, Wahlestedt C. Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts. Trends in Genetics : Tig. 28: 389-96. PMID 22541732 DOI: 10.1016/j.tig.2012.03.013  1
2012 Modarresi F, Faghihi MA, Lopez-Toledano MA, Fatemi RP, Magistri M, Brothers SP, van der Brug MP, Wahlestedt C. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nature Biotechnology. 30: 453-9. PMID 22446693 DOI: 10.1038/nbt.2158  1
2012 Miller BH, Zeier Z, Xi L, Lanz TA, Deng S, Strathmann J, Willoughby D, Kenny PJ, Elsworth JD, Lawrence MS, Roth RH, Edbauer D, Kleiman RJ, Wahlestedt C. MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function. Proceedings of the National Academy of Sciences of the United States of America. 109: 3125-30. PMID 22315408 DOI: 10.1073/pnas.1113793109  1
2011 Modarresi F, Faghihi MA, Patel NS, Sahagan BG, Wahlestedt C, Lopez-Toledano MA. Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis. International Journal of Alzheimer's Disease. 2011: 929042. PMID 21785702 DOI: 10.4061/2011/929042  1
2011 Clark MB, Amaral PP, Schlesinger FJ, Dinger ME, Taft RJ, Rinn JL, Ponting CP, Stadler PF, Morris KV, Morillon A, Rozowsky JS, Gerstein MB, Wahlestedt C, Hayashizaki Y, Carninci P, et al. The reality of pervasive transcription. Plos Biology. 9: e1000625; discussion. PMID 21765801 DOI: 10.1371/journal.pbio.1000625  1
2010 Brothers SP, Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands. Embo Molecular Medicine. 2: 429-39. PMID 20972986 DOI: 10.1002/emmm.201000100  1
2010 Faghihi MA, Kocerha J, Modarresi F, Engström PG, Chalk AM, Brothers SP, Koesema E, St Laurent G, Wahlestedt C. RNAi screen indicates widespread biological function for human natural antisense transcripts. Plos One. 5. PMID 20957177 DOI: 10.1371/journal.pone.0013177  1
2010 Silva JP, Wahlestedt C. Role of Sirtuin 1 in metabolic regulation. Drug Discovery Today. 15: 781-91. PMID 20621197 DOI: 10.1016/j.drudis.2010.07.001  1
2010 Hollander JA, Im HI, Amelio AL, Kocerha J, Bali P, Lu Q, Willoughby D, Wahlestedt C, Conkright MD, Kenny PJ. Striatal microRNA controls cocaine intake through CREB signalling. Nature. 466: 197-202. PMID 20613834 DOI: 10.1038/nature09202  1
2010 Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G, Wahlestedt C. Evidence for natural antisense transcript-mediated inhibition of microRNA function. Genome Biology. 11: R56. PMID 20507594 DOI: 10.1186/gb-2010-11-5-r56  1
2010 Sonntag KC, Wahlestedt C. RNA mechanisms in CNS systems and disorders. Brain Research. 1338: 1-2. PMID 20380824 DOI: 10.1016/j.brainres.2010.04.007  1
2010 Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J, Wahlestedt C, Hutvagner G, Pedersen BK, Timmons JA. Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Medicine. 2: 9. PMID 20353613 DOI: 10.1186/gm130  1
2010 Miller BH, Wahlestedt C. MicroRNA dysregulation in psychiatric disease. Brain Research. 1338: 89-99. PMID 20303342 DOI: 10.1016/j.brainres.2010.03.035  1
2010 van der Brug MP, Wahlestedt C. Navigating genomic maps of cancer cells. Nature Biotechnology. 28: 241-2. PMID 20212487 DOI: 10.1038/nbt0310-241  1
2010 Lopez-Toledano MA, Ali Faghihi M, Patel NS, Wahlestedt C. Adult neurogenesis: a potential tool for early diagnosis in Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 20: 395-408. PMID 20164555 DOI: 10.3233/JAD-2010-1388  1
2010 Timmons JA, Knudsen S, Rankinen T, Koch LG, Sarzynski M, Jensen T, Keller P, Scheele C, Vollaard NB, Nielsen S, Akerström T, MacDougald OA, Jansson E, Greenhaff PL, Tarnopolsky MA, ... ... Wahlestedt C, et al. Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans. Journal of Applied Physiology (Bethesda, Md. : 1985). 108: 1487-96. PMID 20133430 DOI: 10.1152/japplphysiol.01295.2009  1
2010 Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Molecular Pharmacology. 77: 46-57. PMID 19837904 DOI: 10.1124/mol.109.058677  1
2009 St Laurent G, Faghihi MA, Wahlestedt C. Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease. Neuroscience Letters. 466: 81-8. PMID 19699259 DOI: 10.1016/j.neulet.2009.08.032  1
2009 Faghihi MA, Wahlestedt C. Regulatory roles of natural antisense transcripts. Nature Reviews. Molecular Cell Biology. 10: 637-43. PMID 19638999 DOI: 10.1038/nrm2738  1
2009 Kocerha J, Kauppinen S, Wahlestedt C. microRNAs in CNS disorders. Neuromolecular Medicine. 11: 162-72. PMID 19536656 DOI: 10.1007/s12017-009-8066-1  1
2009 Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, ... ... Wahlestedt C, et al. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nature Genetics. 41: 553-62. PMID 19377474 DOI: 10.1038/ng.375  0.36
2009 Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, Orum H, Kauppinen S, Kenny PJ, Wahlestedt C. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 106: 3507-12. PMID 19196972 DOI: 10.1073/pnas.0805854106  1
2008 Shan G, Li Y, Zhang J, Li W, Szulwach KE, Duan R, Faghihi MA, Khalil AM, Lu L, Paroo Z, Chan AW, Shi Z, Liu Q, Wahlestedt C, He C, et al. A small molecule enhances RNA interference and promotes microRNA processing. Nature Biotechnology. 26: 933-40. PMID 18641635 DOI: 10.1038/nbt.1481  1
2008 Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G, Kenny PJ, Wahlestedt C. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nature Medicine. 14: 723-30. PMID 18587408 DOI: 10.1038/nm1784  1
2008 Franks PW, Scheele C, Loos RJ, Nielsen AR, Finucane FM, Wahlestedt C, Pedersen BK, Wareham NJ, Timmons JA. Genomic variants at the PINK1 locus are associated with transcript abundance and plasma nonesterified fatty acid concentrations in European whites. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3135-45. PMID 18495756 DOI: 10.1096/fj.08-107086  1
2008 Dahlgren C, Zhang HY, Du Q, Grahn M, Norstedt G, Wahlestedt C, Liang Z. Analysis of siRNA specificity on targets with double-nucleotide mismatches. Nucleic Acids Research. 36: e53. PMID 18420656 DOI: 10.1093/nar/gkn190  1
2008 Khalil AM, Wahlestedt C. Epigenetic mechanisms of gene regulation during mammalian spermatogenesis. Epigenetics : Official Journal of the Dna Methylation Society. 3: 21-8. PMID 18416029  1
2008 Huang J, Young B, Pletcher MT, Heilig M, Wahlestedt C. Association between the nociceptin receptor gene (OPRL1) single nucleotide polymorphisms and alcohol dependence. Addiction Biology. 13: 88-94. PMID 18269382 DOI: 10.1111/j.1369-1600.2007.00089.x  1
2008 Hong J, Wei N, Chalk A, Wang J, Song Y, Yi F, Qiao RP, Sonnhammer EL, Wahlestedt C, Liang Z, Du Q. Focusing on RISC assembly in mammalian cells. Biochemical and Biophysical Research Communications. 368: 703-8. PMID 18252196 DOI: 10.1016/j.bbrc.2008.01.116  1
2008 Khalil AM, Faghihi MA, Modarresi F, Brothers SP, Wahlestedt C. A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. Plos One. 3: e1486. PMID 18213394 DOI: 10.1371/journal.pone.0001486  1
2008 Kemmer D, Podowski RM, Yusuf D, Brumm J, Cheung W, Wahlestedt C, Lenhard B, Wasserman WW. Gene characterization index: assessing the depth of gene annotation. Plos One. 3: e1440. PMID 18213364 DOI: 10.1371/journal.pone.0001440  1
2007 St Laurent G, Wahlestedt C. Noncoding RNAs: couplers of analog and digital information in nervous system function? Trends in Neurosciences. 30: 612-21. PMID 17996312 DOI: 10.1016/j.tins.2007.10.002  1
2007 Scheele C, Nielsen AR, Walden TB, Sewell DA, Fischer CP, Brogan RJ, Petrovic N, Larsson O, Tesch PA, Wennmalm K, Hutchinson DS, Cannon B, Wahlestedt C, Pedersen BK, Timmons JA. Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3653-65. PMID 17567565 DOI: 10.1096/fj.07-8520com  1
2007 Scheele C, Petrovic N, Faghihi MA, Lassmann T, Fredriksson K, Rooyackers O, Wahlestedt C, Good L, Timmons JA. The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function. Bmc Genomics. 8: 74. PMID 17362513 DOI: 10.1186/1471-2164-8-74  1
2007 Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N, Hamilton DL, Gimeno RE, Wahlestedt C, Baar K, Nedergaard J, Cannon B. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proceedings of the National Academy of Sciences of the United States of America. 104: 4401-6. PMID 17360536 DOI: 10.1073/pnas.0610615104  1
2007 Timmons JA, Scheele C, Wahlestedt C. Do mitochondria provide a common link between diabetes and Parkinson's disease? Practical Diabetes International. 24: 337-339. DOI: 10.1002/pdi.1136  1
2006 Larsson O, Perlman DM, Fan D, Reilly CS, Peterson M, Dahlgren C, Liang Z, Li S, Polunovsky VA, Wahlestedt C, Bitterman PB. Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure. Nucleic Acids Research. 34: 4375-86. PMID 16936314 DOI: 10.1093/nar/gkl558  1
2006 Zhang HY, Du Q, Wahlestedt C, Liang Z. RNA Interference with chemically modified siRNA. Current Topics in Medicinal Chemistry. 6: 893-900. PMID 16787282 DOI: 10.2174/156802606777303676  1
2006 Wahlestedt C. Natural antisense and noncoding RNA transcripts as potential drug targets. Drug Discovery Today. 11: 503-8. PMID 16713901 DOI: 10.1016/j.drudis.2006.04.013  1
2006 Faghihi MA, Wahlestedt C. RNA interference is not involved in natural antisense mediated regulation of gene expression in mammals. Genome Biology. 7: R38. PMID 16684369 DOI: 10.1186/gb-2006-7-5-r38  1
2006 Engström PG, Suzuki H, Ninomiya N, Akalin A, Sessa L, Lavorgna G, Brozzi A, Luzi L, Tan SL, Yang L, Kunarso G, Ng EL, Batalov S, Wahlestedt C, Kai C, et al. Complex Loci in human and mouse genomes. Plos Genetics. 2: e47. PMID 16683030 DOI: 10.1371/journal.pgen.0020047  1
2006 Frith MC, Wilming LG, Forrest A, Kawaji H, Tan SL, Wahlestedt C, Bajic VB, Kai C, Kawai J, Carninci P, Hayashizaki Y, Bailey TL, Huminiecki L. Pseudo-messenger RNA: phantoms of the transcriptome. Plos Genetics. 2: e23. PMID 16683022 DOI: 10.1371/journal.pgen.0020023  1
2006 Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS, Engström PG, Frith MC, Forrest AR, Alkema WB, Tan SL, Plessy C, Kodzius R, ... ... Wahlestedt C, et al. Genome-wide analysis of mammalian promoter architecture and evolution. Nature Genetics. 38: 626-35. PMID 16645617 DOI: 10.1038/ng1789  1
2006 Dahlgren C, Wahlestedt C, Thonberg H. No induction of anti-viral responses in human cell lines HeLa and MCF-7 when transfecting with siRNA or siLNA. Biochemical and Biophysical Research Communications. 341: 1211-7. PMID 16476582 DOI: 10.1016/j.bbrc.2006.01.085  1
2006 Fredman D, Sawyer SL, Strömqvist L, Mottagui-Tabar S, Kidd KK, Wahlestedt C, Chanock SJ, Brookes AJ. Nonsynonymous SNPs: validation characteristics, derived allele frequency patterns, and suggestive evidence for natural selection. Human Mutation. 27: 173-86. PMID 16429399 DOI: 10.1002/humu.20289  1
2006 Timmons JA, Norrbom J, Schéele C, Thonberg H, Wahlestedt C, Tesch P. Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes. Genomics. 87: 165-72. PMID 16326070 DOI: 10.1016/j.ygeno.2005.09.007  1
2005 Wennmalm K, Wahlestedt C, Larsson O. The expression signature of in vitro senescence resembles mouse but not human aging. Genome Biology. 6: R109. PMID 16420669 DOI: 10.1186/gb-2005-6-13-r109  1
2005 Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, Nishida H, Yap CC, Suzuki M, Kawai J, Suzuki H, Carninci P, Hayashizaki Y, Wells C, Frith M, ... ... Wahlestedt C, et al. Antisense transcription in the mammalian transcriptome. Science (New York, N.Y.). 309: 1564-6. PMID 16141073 DOI: 10.1126/science.1112009  1
2005 Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, ... ... Wahlestedt C, et al. The transcriptional landscape of the mammalian genome. Science (New York, N.Y.). 309: 1559-63. PMID 16141072 DOI: 10.1126/science.1112014  0.36
2005 McCarthy S, Mottagui-Tabar S, Mizuno Y, Sennblad B, Hoffstedt J, Arner P, Wahlestedt C, Andersson B. Complex HTR2C linkage disequilibrium and promoter associations with body mass index and serum leptin. Human Genetics. 117: 545-57. PMID 16021472 DOI: 10.1007/s00439-005-1328-6  1
2005 Larsson O, Wahlestedt C, Timmons JA. Considerations when using the significance analysis of microarrays (SAM) algorithm. Bmc Bioinformatics. 6: 129. PMID 15921534 DOI: 10.1186/1471-2105-6-129  1
2005 Mottagui-Tabar S, Prince JA, Wahlestedt C, Zhu G, Goldman D, Heilig M. A novel single nucleotide polymorphism of the neuropeptide Y (NPY) gene associated with alcohol dependence. Alcoholism, Clinical and Experimental Research. 29: 702-7. PMID 15897713 DOI: 10.1097/01.ALC.0000164365.04961.B1  1
2005 Timmons JA, Larsson O, Jansson E, Fischer H, Gustafsson T, Greenhaff PL, Ridden J, Rachman J, Peyrard-Janvid M, Wahlestedt C, Sundberg CJ. Human muscle gene expression responses to endurance training provide a novel perspective on Duchenne muscular dystrophy. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 750-60. PMID 15857889 DOI: 10.1096/fj.04-1980com  1
2005 Du Q, Thonberg H, Wang J, Wahlestedt C, Liang Z. A systematic analysis of the silencing effects of an active siRNA at all single-nucleotide mismatched target sites. Nucleic Acids Research. 33: 1671-7. PMID 15781493 DOI: 10.1093/nar/gki312  1
2005 Mottagui-Tabar S, Faghihi MA, Mizuno Y, Engström PG, Lenhard B, Wasserman WW, Wahlestedt C. Identification of functional SNPs in the 5-prime flanking sequences of human genes. Bmc Genomics. 6: 18. PMID 15717931 DOI: 10.1186/1471-2164-6-18  1
2005 Chen M, Zhang L, Zhang HY, Xiong X, Wang B, Du Q, Lu B, Wahlestedt C, Liang Z. A universal plasmid library encoding all permutations of small interfering RNA. Proceedings of the National Academy of Sciences of the United States of America. 102: 2356-61. PMID 15695593 DOI: 10.1073/pnas.0401549101  1
2005 Ding B, Kull B, Liu Z, Mottagui-Tabar S, Thonberg H, Gu HF, Brookes AJ, Grundemar L, Karlsson C, Hamsten A, Arner P, Ostenson CG, Efendic S, Monné M, von Heijne G, ... ... Wahlestedt C, et al. Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function. Regulatory Peptides. 127: 45-53. PMID 15680469 DOI: 10.1016/j.regpep.2004.10.011  1
2005 Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, Wahren B, Liang Z, Ørum H, Koch T, Wahlestedt C. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Research. 33: 439-47. PMID 15653644 DOI: 10.1093/nar/gki193  1
2005 Pang KC, Stephen S, Engström PG, Tajul-Arifin K, Chen W, Wahlestedt C, Lenhard B, Hayashizaki Y, Mattick JS. RNAdb--a comprehensive mammalian noncoding RNA database. Nucleic Acids Research. 33: D125-30. PMID 15608161 DOI: 10.1093/nar/gki089  1
2004 Kemmer D, Faxén M, Hodges E, Lim J, Herzog E, Ljungström E, Lundmark A, Olsen MK, Podowski R, Sonnhammer EL, Nilsson P, Reimers M, Lenhard B, Roberds SL, Wahlestedt C, et al. Exploring the foundation of genomics: a northern blot reference set for the comparative analysis of transcript profiling technologies. Comparative and Functional Genomics. 5: 584-95. PMID 18629180 DOI: 10.1002/cfg.443  1
2004 Thonberg H, Dahlgren C, Wahlestedt C. Antisense-induced Fas mRNA degradation produces site-specific stable 3'-mRNA fragment by exonuclease cleavage at the complementary sequence. Oligonucleotides. 14: 221-6. PMID 15625917 DOI: 10.1089/oli.2004.14.221  1
2004 Elmén J, Zhang HY, Zuber B, Ljungberg K, Wahren B, Wahlestedt C, Liang Z. Locked nucleic acid containing antisense oligonucleotides enhance inhibition of HIV-1 genome dimerization and inhibit virus replication. Febs Letters. 578: 285-90. PMID 15589834 DOI: 10.1016/j.febslet.2004.11.015  1
2004 Wahlestedt C, Brookes AJ, Mottagui-Tabar S. Lower rate of genomic variation identified in the trans-membrane domain of monoamine sub-class of Human G-Protein Coupled Receptors: the Human GPCR-DB Database. Bmc Genomics. 5: 91. PMID 15579207 DOI: 10.1186/1471-2164-5-91  1
2004 Du Q, Thonberg H, Zhang HY, Wahlestedt C, Liang Z. Validating siRNA using a reporter made from synthetic DNA oligonucleotides. Biochemical and Biophysical Research Communications. 325: 243-9. PMID 15522225 DOI: 10.1016/j.bbrc.2004.09.222  1
2004 Mottagui-Tabar S, McCarthy S, Reinemund J, Andersson B, Wahlestedt C, Heilig M. Analysis of 5-hydroxytryptamine 2c receptor gene promoter variants as alcohol-dependence risk factors. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 380-5. PMID 15304380 DOI: 10.1093/alcalc/agh086  1
2004 Chalk AM, Wahlestedt C, Sonnhammer EL. Improved and automated prediction of effective siRNA. Biochemical and Biophysical Research Communications. 319: 264-74. PMID 15158471 DOI: 10.1016/j.bbrc.2004.04.181  1
2004 Thonberg H, Schéele CC, Dahlgren C, Wahlestedt C. Characterization of RNA interference in rat PC12 cells: requirement of GERp95. Biochemical and Biophysical Research Communications. 318: 927-34. PMID 15147961 DOI: 10.1016/j.bbrc.2004.04.119  1
2004 Faghihi MA, Mottagui-Tabar S, Wahlestedt C. Genetics of neurological disorders. Expert Review of Molecular Diagnostics. 4: 317-32. PMID 15137899 DOI: 10.1586/14737159.4.3.317  1
2004 Xu Y, Linde A, Larsson O, Thormeyer D, Elmen J, Wahlestedt C, Liang Z. Functional comparison of single- and double-stranded siRNAs in mammalian cells. Biochemical and Biophysical Research Communications. 316: 680-7. PMID 15033453 DOI: 10.1016/j.bbrc.2004.02.100  1
2004 Isacson R, Kull B, Wahlestedt C, Salmi P. A 68930 and dihydrexidine inhibit locomotor activity and d-amphetamine-induced hyperactivity in rats: a role of inhibitory dopamine D(1/5) receptors in the prefrontal cortex? Neuroscience. 124: 33-42. PMID 14960337 DOI: 10.1016/j.neuroscience.2003.11.016  1
2004 Heilig M, Zachrisson O, Thorsell A, Ehnvall A, Mottagui-Tabar S, Sjögren M, Asberg M, Ekman R, Wahlestedt C, Agren H. Decreased cerebrospinal fluid neuropeptide Y (NPY) in patients with treatment refractory unipolar major depression: preliminary evidence for association with preproNPY gene polymorphism. Journal of Psychiatric Research. 38: 113-21. PMID 14757324 DOI: 10.1016/S0022-3956(03)00101-8  1
2004 Gu HF, Abulaiti A, Ostenson CG, Humphreys K, Wahlestedt C, Brookes AJ, Efendic S. Single nucleotide polymorphisms in the proximal promoter region of the adiponectin (APM1) gene are associated with type 2 diabetes in Swedish caucasians. Diabetes. 53: S31-5. PMID 14749263  1
2004 Larsson O, Scheele C, Liang Z, Moll J, Karlsson C, Wahlestedt C. Kinetics of senescence-associated changes of gene expression in an epithelial, temperature-sensitive SV40 large T antigen model. Cancer Research. 64: 482-9. PMID 14744760 DOI: 10.1158/0008-5472.CAN-03-1872  1
2003 Isacson R, Kull B, Salmi P, Wahlestedt C. Lack of efficacy of 'naked' small interfering RNA applied directly to rat brain. Acta Physiologica Scandinavica. 179: 173-7. PMID 14510781 DOI: 10.1046/j.1365-201X.2003.01188.x  1
2003 Zhang HY, Mao J, Zhou D, Xu Y, Thonberg H, Liang Z, Wahlestedt C. mRNA accessible site tagging (MAST): a novel high throughput method for selecting effective antisense oligonucleotides. Nucleic Acids Research. 31: e72. PMID 12853649  1
2003 Kela J, Salmi P, Rimondini-Giorgini R, Heilig M, Wahlestedt C. Behavioural analysis of melanin-concentrating hormone in rats: evidence for orexigenic and anxiolytic properties. Regulatory Peptides. 114: 109-14. PMID 12832098 DOI: 10.1016/S0167-0115(03)00114-9  1
2003 Lenhard B, Wahlestedt C, Wasserman WW. GeneLynx mouse: integrated portal to the mouse genome. Genome Research. 13: 1501-4. PMID 12819149 DOI: 10.1101/gr.951403  1
2003 Xu Y, Zhang HY, Thormeyer D, Larsson O, Du Q, Elmén J, Wahlestedt C, Liang Z. Effective small interfering RNAs and phosphorothioate antisense DNAs have different preferences for target sites in the luciferase mRNAs. Biochemical and Biophysical Research Communications. 306: 712-7. PMID 12810077 DOI: 10.1016/S0006-291X(03)01024-6  1
2003 Ahlqvist J, Isacson R, Wahlestedt C, Salmi P. Anti-cataleptic effects of clozapine, but not olanzapine and quetiapine, on SCH 23390- or raclopride-induced catalepsy in rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 177-82. PMID 12729943 DOI: 10.1016/S0924-977X(03)00004-X  1
2003 Josephson A, Trifunovski A, Schéele C, Widenfalk J, Wahlestedt C, Brené S, Olson L, Spenger C. Activity-induced and developmental downregulation of the Nogo receptor. Cell and Tissue Research. 311: 333-42. PMID 12658441 DOI: 10.1007/s00441-002-0695-8  1
2003 Eriksson A, Cao R, Roy J, Tritsaris K, Wahlestedt C, Dissing S, Thyberg J, Cao Y. Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability. Circulation. 107: 1532-8. PMID 12654612 DOI: 10.1161/01.CIR.0000055324.34758.32  1
2003 Thormeyer D, Ammerpohl O, Larsson O, Xu Y, Asinger A, Wahlestedt C, Liang Z. Characterization of lacZ complementation deletions using membrane receptor dimerization. Biotechniques. 34: 346-50, 352-5. PMID 12613257  1
2003 Wahlestedt C. Array of possibilities. Pharmacogenetics. 13: 1. PMID 12544506 DOI: 10.1097/00008571-200301000-00001  1
2003 Zhu G, Pollak L, Mottagui-Tabar S, Wahlestedt C, Taubman J, Virkkunen M, Goldman D, Heilig M. NPY Leu7Pro and alcohol dependence in Finnish and Swedish populations. Alcoholism, Clinical and Experimental Research. 27: 19-24. PMID 12544000 DOI: 10.1097/01.ALC.0000050642.62233.44  1
2003 Salmi P, Kela J, Arvidsson U, Wahlestedt C. Functional interactions between delta- and mu-opioid receptors in rat thermoregulation. European Journal of Pharmacology. 458: 101-6. PMID 12498912 DOI: 10.1016/S0014-2999(02)02736-X  1
2002 Larsson O, Thormeyer D, Asinger A, Wihlén B, Wahlestedt C, Liang Z. Quantitative codon optimisation of DNA libraries encoding sub-random peptides: design and characterisation of a novel library encoding transmembrane domain peptides. Nucleic Acids Research. 30: e133. PMID 12466565  1
2002 Li J, Protopopov A, Wang F, Senchenko V, Petushkov V, Vorontsova O, Petrenko L, Zabarovska V, Muravenko O, Braga E, Kisselev L, Lerman MI, Kashuba V, Klein G, Ernberg I, ... Wahlestedt C, et al. NotI subtraction and NotI-specific microarrays to detect copy number and methylation changes in whole genomes. Proceedings of the National Academy of Sciences of the United States of America. 99: 10724-9. PMID 12149436 DOI: 10.1073/pnas.132271699  1
2002 Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, ... Wahlestedt C, et al. NotI flanking sequences: a tool for gene discovery and verification of the human genome. Nucleic Acids Research. 30: 3163-70. PMID 12136098  1
2002 Ding B, Bertilsson L, Wahlestedt C. The single nucleotide polymorphism T1128C in the signal peptide of neuropeptide Y (NPY) was not identified in a Korean population. Journal of Clinical Pharmacy and Therapeutics. 27: 211-2. PMID 12081635 DOI: 10.1046/j.1365-2710.2002.00409.x  1
2002 Kashuba VI, Protopopov AI, Kvasha SM, Gizatullin RZ, Wahlestedt C, Kisselev LL, Klein G, Zabarovsky ER. hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein. Gene. 283: 209-17. PMID 11867227 DOI: 10.1016/S0378-1119(01)00856-3  1
2002 Zabarovska VI, Gizatullin RZ, Al-Amin AN, Podowski R, Protopopov AI, Löfdahl S, Wahlestedt C, Winberg G, Kashuba VI, Ernberg I, Zabarovsky ER. A new approach to genome mapping and sequencing: slalom libraries. Nucleic Acids Research. 30: E6. PMID 11788732  1
2002 Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proceedings of the National Academy of Sciences of the United States of America. 99: 2344-9. PMID 11782534 DOI: 10.1073/pnas.022438099  1
2001 Li J, Wang F, Kashuba V, Wahlestedt C, Zabarovsky ER. Cloning of deleted sequences (CODE): A genomic subtraction method for enriching and cloning deleted sequences. Biotechniques. 31: 788, 790, 792-3. PMID 11680709  1
2001 Sollerbrant K, Elmén J, Wahlestedt C, Acker J, Leblois-Prehaud H, Latta-Mahieu M, Yeh P, Perricaudet M. A novel method using baculovirus-mediated gene transfer for production of recombinant adeno-associated virus vectors. The Journal of General Virology. 82: 2051-60. PMID 11514714  1
2001 Kashuba VI, Kvasha SM, Protopopov AI, Gizatullin RZ, Rynditch AV, Wahlestedt C, Wasserman WW, Zabarovsky ER. Initial isolation and analysis of the human Kv1.7 (KCNA7) gene, a member of the voltage-gated potassium channel gene family. Gene. 268: 115-22. PMID 11368907 DOI: 10.1016/S0378-1119(01)00423-1  1
2001 Schrimpf SP, Langen H, Gomes AV, Wahlestedt C. A two-dimensional protein map of Caenorhabditis elegans. Electrophoresis. 22: 1224-32. PMID 11358149 DOI: 10.1002/1522-2683()22:6<1224::AID-ELPS1224>3.0.CO;2-I  1
2001 Cao R, Brakenhielm E, Wahlestedt C, Thyberg J, Cao Y. Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. Proceedings of the National Academy of Sciences of the United States of America. 98: 6390-5. PMID 11344271 DOI: 10.1073/pnas.101564798  1
2001 Wahlestedt C. Using genomics to understand the nervous system Drug Discovery Today. 6: S81-S85.  1
2000 Fraser GL, Pradhan AA, Clarke PB, Wahlestedt C. Supraspinal antinociceptive response to [D-Pen(2,5)]-enkephalin (DPDPE) is pharmacologically distinct from that to other delta-agonists in the rat. The Journal of Pharmacology and Experimental Therapeutics. 295: 1135-41. PMID 11082450  1
2000 Good L, Sandberg R, Larsson O, Nielsen PE, Wahlestedt C. Antisense PNA effects in Escherichia coli are limited by the outer-membrane LPS layer. Microbiology (Reading, England). 146: 2665-70. PMID 11021941  1
2000 Hoja MR, Wahlestedt C, Höög C. A visual intracellular classification strategy for uncharacterized human proteins. Experimental Cell Research. 259: 239-46. PMID 10942595 DOI: 10.1006/excr.2000.4948  1
2000 Kashuba V, Protopopov A, Podowski R, Gizatullin R, Li J, Klein G, Wahlestedt C, Zabarovsky E. Isolation and chromosomal localization of a new human retinoblastoma binding protein 2 homologue 1a (RBBP2H1A). European Journal of Human Genetics : Ejhg. 8: 407-13. PMID 10878660 DOI: 10.1038/sj.ejhg.5200474  1
2000 Vaz Gomes A, Wahlestedt C. Altered behaviour following RNA interference knockdown of a C. elegans G-protein coupled receptor by ingested double stranded RNA. European Journal of Pharmacology. 397: R3-5. PMID 10844141 DOI: 10.1016/S0014-2999(00)00251-X  1
2000 Protopopov A, Kashuba V, Podowski R, Gizatullin R, Sonnhammer E, Wahlestedt C, Zabarovsky ER. Assignment of the GPR14 gene coding for the G-protein-coupled receptor 14 to human chromosome 17q25.3 by fluorescent in situ hybridization. Cytogenetics and Cell Genetics. 88: 312-3. PMID 10828617  1
2000 Wahlestedt C, Salmi P, Good L, Kela J, Johnsson T, Hökfelt T, Broberger C, Porreca F, Lai J, Ren K, Ossipov M, Koshkin A, Jakobsen N, Skouv J, Oerum H, et al. Potent and nontoxic antisense oligonucleotides containing locked nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 97: 5633-8. PMID 10805816 DOI: 10.1073/pnas.97.10.5633  1
2000 Zabarovska V, Li J, Muravenko O, Fedorova L, Braga E, Ernberg I, Wahlestedt C, Klein G, Zabarovsky ER. CIS--cloning of identical sequences between two complex genomes. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 8: 77-84. PMID 10730592 DOI: 10.1023/A:1009243606611  1
2000 Fraser GL, Holmgren J, Clarke PB, Wahlestedt C. Antisense inhibition of delta-opioid receptor gene function in vivo by peptide nucleic acids. Molecular Pharmacology. 57: 725-31. PMID 10727518  1
2000 Zabarovsky ER, Gizatullin R, Podowski RM, Zabarovska VV, Xie L, Muravenko OV, Kozyrev S, Petrenko L, Skobeleva N, Li J, Protopopov A, Kashuba V, Ernberg I, Winberg G, Wahlestedt C. NotI clones in the analysis of the human genome. Nucleic Acids Research. 28: 1635-9. PMID 10710430  1
2000 Salmi P, Sproat BS, Ludwig J, Hale R, Avery N, Kela J, Wahlestedt C. Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats. European Journal of Pharmacology. 388: R1-2. PMID 10657555 DOI: 10.1016/S0014-2999(99)00866-3  1
2000 Li J, Wang F, Zabarovska V, Wahlestedt C, Zabarovsky ER. Cloning of polymorphisms (COP): enrichment of polymorphic sequences from complex genomes. Nucleic Acids Research. 28: e1. PMID 10606669  1
1999 Wahlestedt C, Good L. Antisense oligonucleotides - the way forward. Current Opinion in Drug Discovery & Development. 2: 142-6. PMID 19649940  1
1999 Eriksson A, Wahlestedt C, Nordqvist K. Isolation of sex-specific cDNAs from fetal mouse brain using mRNA differential display and representational difference analysis. Brain Research. Molecular Brain Research. 74: 91-7. PMID 10640679 DOI: 10.1016/S0169-328X(99)00265-X  1
1999 Kashuba VI, Gizatullin RZ, Protopopov AI, Li J, Vorobieva NV, Fedorova L, Zabarovska VI, Muravenko OV, Kost-Alimova M, Domninsky DA, Kiss C, Allikmets R, Zakharyev VM, Braga EA, Sumegi J, ... ... Wahlestedt C, et al. Analysis of NotI linking clones isolated from human chromosome 3 specific libraries. Gene. 239: 259-71. PMID 10548727 DOI: 10.1016/S0378-1119(99)00411-4  1
1999 O'Donnell D, Ahmad S, Wahlestedt C, Walker P. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. The Journal of Comparative Neurology. 409: 469-81. PMID 10379831 DOI: 10.1002/(SICI)1096-9861(19990705)409:3<469::AID-CNE10>3.0.CO;2-Q  1
1998 Ahmad S, O'Donnell D, Payza K, Ducharme J, Ménard D, Brown W, Schmidt R, Wahlestedt C, Shen SH, Walker P. Cloning and evaluation of the role of rat GALR-2, a novel subtype of galanin receptor, in the control of pain perception. Annals of the New York Academy of Sciences. 863: 108-19. PMID 9928164 DOI: 10.1111/j.1749-6632.1998.tb10688.x  1
1998 Wahlestedt C. Reward for persistence in substance P research. Science (New York, N.Y.). 281: 1624-5. PMID 9767028 DOI: 10.1126/science.281.5383.1624  1
1997 Emilsson K, Wahlestedt C, Sun MK, Nystedt S, Owman C, Sundelin J. Vascular effects of proteinase-activated receptor 2 agonist peptide. Journal of Vascular Research. 34: 267-72. PMID 9256086  1
1997 Pepin MC, Yue SY, Roberts E, Wahlestedt C, Walker P. Novel "restoration of function" mutagenesis strategy to identify amino acids of the delta-opioid receptor involved in ligand binding. The Journal of Biological Chemistry. 272: 9260-7. PMID 9083060 DOI: 10.1074/jbc.272.14.9260  1
1996 Weng G, Feinstein D, Reis D, Wahlestedt C. Neuropeptide Y receptor gene regulation in mouse adrenocortical Y-1 cells. Regulatory Peptides. 63: 53-6. PMID 8795089 DOI: 10.1016/0167-0115(96)00030-4  1
1996 Sun XY, Zhao XH, Erlinge D, Edvinsson L, Fallgren B, Wahlestedt C, Hedner T. Effects of phosphorothioated neuropeptide Y Y1-receptor antisense oligodeoxynucleotide in conscious rats and in human vessels. British Journal of Pharmacology. 118: 131-6. PMID 8733585  1
1996 Sun X, You J, Hedner T, Erlinge D, Fellström B, Yoo H, Wahlestedt C, Edvinsson L. alpha-Trinositol: a functional (non-receptor) neuropeptide Y antagonist in vasculature. The Journal of Pharmacy and Pharmacology. 48: 77-84. PMID 8722501  1
1996 Valiquette M, Vu HK, Yue SY, Wahlestedt C, Walker P. Involvement of Trp-284, Val-296, and Val-297 of the human delta-opioid receptor in binding of delta-selective ligands. The Journal of Biological Chemistry. 271: 18789-96. PMID 8702536 DOI: 10.1074/jbc.271.31.18789  1
1995 Erlinge D, You J, Wahlestedt C, Edvinsson L. Characterisation of an ATP receptor mediating mitogenesis in vascular smooth muscle cells. European Journal of Pharmacology. 289: 135-49. PMID 7781705 DOI: 10.1016/0922-4106(95)90178-7  1
1995 Sun XY, Edvinsson L, Yoo H, Wahlestedt C, Hedner T. Effects of some novel D-myo-inositol-phosphate derivatives on binding and sympathetic transmission. Journal of Cardiovascular Pharmacology. 25: 696-704. PMID 7630147  1
1995 Weng G, Yee F, Michl P, Reis D, Wahlestedt C. Studies on neuropeptide Y receptors in a mouse adrenocortical cell line. Molecular Pharmacology. 48: 9-14. PMID 7623780  1
1995 Fraser GL, Wahlestedt C. Section review: Biologicals & immunologicals: Applications of antisense technology to both basic and clinical Research Expert Opinion On Investigational Drugs. 4: 637-646. DOI: 10.1517/13543784.4.7.637  1
1994 Wahlestedt C. Antisense oligonucleotide strategies in neuropharmacology. Trends in Pharmacological Sciences. 15: 42-6. PMID 8165722 DOI: 10.1016/0165-6147(94)90107-4  1
1994 Akabayashi A, Wahlestedt C, Alexander JT, Leibowitz SF. Specific inhibition of endogenous neuropeptide Y synthesis in arcuate nucleus by antisense oligonucleotides suppresses feeding behavior and insulin secretion. Brain Research. Molecular Brain Research. 21: 55-61. PMID 8164522 DOI: 10.1016/0169-328X(94)90377-8  1
1994 Nystedt S, Emilsson K, Wahlestedt C, Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 9208-12. PMID 7937743  1
1994 Yoo H, Fallgren B, Lindahl A, Wahlestedt C. Characterization of specific binding sites for alpha-trinositol (D-myo-inositol 1,2,6-trisphosphate) in rat tissues. European Journal of Pharmacology. 268: 55-63. PMID 7925612 DOI: 10.1016/0922-4106(94)90119-8  1
1994 Akabayashi A, Watanabe Y, Wahlestedt C, McEwen BS, Paez X, Leibowitz SF. Hypothalamic neuropeptide Y, its gene expression and receptor activity: relation to circulating corticosterone in adrenalectomized rats. Brain Research. 665: 201-12. PMID 7895055 DOI: 10.1016/0006-8993(94)91339-0  1
1994 Adner M, Erlinge D, Salford LG, Yee F, Wahlestedt C, Edvinsson L. Human endothelin ETA receptor antisense oligodeoxynucleotides inhibit endothelin-1 evoked vasoconstriction. European Journal of Pharmacology. 261: 281-4. PMID 7813549 DOI: 10.1016/0014-2999(94)90118-X  1
1994 Yee F, Ericson H, Reis DJ, Wahlestedt C. Cellular uptake of intracerebroventricularly administered biotin- or digoxigenin-labeled antisense oligodeoxynucleotides in the rat. Cellular and Molecular Neurobiology. 14: 475-86. PMID 7621508 DOI: 10.1007/BF02088832  1
1993 Wahlestedt C, Reis DJ. Neuropeptide Y-related peptides and their receptors--are the receptors potential therapeutic drug targets? Annual Review of Pharmacology and Toxicology. 33: 309-52. PMID 8494343 DOI: 10.1146/annurev.pa.33.040193.001521  1
1993 Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, Inturrisi CE, Reis DJ. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarctions. Nature. 363: 260-3. PMID 8487863 DOI: 10.1038/363260a0  1
1993 Zukowska-Grojec Z, Pruszczyk P, Colton C, Yao J, Shen GH, Myers AK, Wahlestedt C. Mitogenic effect of neuropeptide Y in rat vascular smooth muscle cells. Peptides. 14: 263-8. PMID 8483806 DOI: 10.1016/0196-9781(93)90040-N  1
1993 Erlinge D, Edvinsson L, Brunkwall J, Yee F, Wahlestedt C. Human neuropeptide Y Y1 receptor antisense oligodeoxynucleotide specifically inhibits neuropeptide Y-evoked vasoconstriction. European Journal of Pharmacology. 240: 77-80. PMID 8405124 DOI: 10.1016/0014-2999(93)90548-V  1
1993 Larhammar D, Blomqvist AG, Wahlestedt C. The receptor revolution--multiplicity of G-protein-coupled receptors. Drug Design and Discovery. 9: 179-88. PMID 8400001  1
1993 Grundemar L, Wahlestedt C, Wang ZY. Neuropeptide Y suppresses the neurogenic inflammatory response in the rabbit eye; mode of action. Regulatory Peptides. 43: 57-64. PMID 8381238 DOI: 10.1016/0167-0115(93)90407-Y  1
1993 Wahlestedt C, Pich EM, Koob GF, Yee F, Heilig M. Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodeoxynucleotides. Science (New York, N.Y.). 259: 528-31. PMID 8380941  1
1993 Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C. A proposed bovine neuropeptide Y (NPY) receptor cDNA clone, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regulatory Peptides. 47: 247-58. PMID 8234909 DOI: 10.1016/0167-0115(93)90392-L  1
1993 Zukowska-Grojec Z, Golczynska M, Shen GH, Torres-Duarte A, Haass M, Wahlestedt C, Myers AK. Modulation of vascular function by neuropeptide Y during development of hypertension in spontaneously hypertensive rats. Pediatric Nephrology (Berlin, Germany). 7: 845-52. PMID 7907499 DOI: 10.1007/BF01213372  1
1993 Erlinge D, Yoo H, Edvinsson L, Reis DJ, Wahlestedt C. Mitogenic effects of ATP on vascular smooth muscle cells vs. other growth factors and sympathetic cotransmitters. The American Journal of Physiology. 265: H1089-97. PMID 7694483  1
1993 Franklin SO, Elliott K, Zhu YS, Wahlestedt C, Inturrisi CE. Quantitation of NMDA receptor (NMDAR1) mRNA levels in the adult and developing rat CNS. Brain Research. Molecular Brain Research. 19: 93-100. PMID 7689684 DOI: 10.1016/0169-328X(93)90153-G  1
1992 Regunathan S, Reis DJ, Wahlestedt C. Specific binding of inositol hexakisphosphate (phytic acid) to adrenal chromaffin cell membranes and effects on calcium-dependent catecholamine release. Biochemical Pharmacology. 43: 1331-6. PMID 1562283 DOI: 10.1016/0006-2952(92)90510-P  1
1992 Sun MK, Wahlestedt C, Reis DJ. Inositol hexakisphosphate excites rat medullary sympathoexcitatory neurons in vivo. European Journal of Pharmacology. 215: 9-16. PMID 1516653 DOI: 10.1016/0014-2999(92)90601-Y  1
1992 Sun MK, Wahlestedt C, Reis DJ. Action of externally applied ATP on rat reticulospinal vasomotor neurons. European Journal of Pharmacology. 224: 93-6. PMID 1451746 DOI: 10.1016/0014-2999(92)94824-F  1
1992 Wahlestedt C, Reis DJ, Yoo H, Adamsson M, Andersson D, Edvinsson L. A novel inositol phosphate selectively inhibits vasoconstriction evoked by the sympathetic co-transmitters neuropeptide Y (NPY) and adenosine triphosphate (ATP). Neuroscience Letters. 143: 123-6. PMID 1436655 DOI: 10.1016/0304-3940(92)90247-5  1
1992 Sundelin JB, Provvedini DM, Wahlestedt CR, Laurell H, Pohl JS, Peterson PA. Molecular cloning of the murine substance K and substance P receptor genes. European Journal of Biochemistry / Febs. 203: 625-31. PMID 1370937  1
1992 Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlestedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type Journal of Biological Chemistry. 267: 10935-10938. PMID 1317848  1
1992 Grundemar L, Jonas SE, Mörner N, Högestätt ED, Wahlestedt C, HÃ¥kanson R. Characterization of vascular neuropeptide Y receptors. British Journal of Pharmacology. 105: 45-50. PMID 1317737  1
1992 Wahlestedt C, Regunathan S, Reis DJ. Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sciences. 50: PL7-12. PMID 1310131 DOI: 10.1016/0024-3205(92)90342-M  1
1991 Wahlestedt C, Karoum F, Jaskiw G, Wyatt RJ, Larhammar D, Ekman R, Reis DJ. Cocaine-induced reduction of brain neuropeptide Y synthesis dependent on medial prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 88: 2078-82. PMID 2006146  1
1991 Shen GH, Grundemar L, Zukowska-Grojec Z, HÃ¥kanson R, Wahlestedt C. C-terminal neuropeptide Y fragments are mast cell-dependent vasodepressor agents. European Journal of Pharmacology. 204: 249-56. PMID 1723049 DOI: 10.1016/0014-2999(91)90849-L  1
1991 Wahlestedt C. Strategies to detect heterologously expressed tachykinin receptors in Xenopus Oocytes. Annals of the New York Academy of Sciences. 632: 116-22. PMID 1719860  1
1991 Heilig M, Edvinsson L, Wahlestedt C. Effects of intracerebroventricular D-myo-inositol-1,2,6-trisphosphate (PP56), a proposed neuropeptide Y (NPY) antagonist, on locomotor activity, food intake, central effects of NPY and NPY-receptor binding. European Journal of Pharmacology. 209: 27-32. PMID 1667639 DOI: 10.1016/0014-2999(91)90006-C  1
1991 Aicher SA, Springston M, Berger SB, Reis DJ, Wahlestedt C. Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain. Neuroscience Letters. 130: 32-6. PMID 1660972 DOI: 10.1016/0304-3940(91)90220-N  1
1990 Wahlestedt C, Blendy JA, Kellar KJ, Heilig M, Widerlöv E, Ekman R. Electroconvulsive shocks increase the concentration of neocortical and hippocampal neuropeptide Y (NPY)-like immunoreactivity in the rat. Brain Research. 507: 65-8. PMID 2302581 DOI: 10.1016/0006-8993(90)90523-E  1
1987 Kannisto P, HÃ¥kanson R, Owman C, Schmidt G, Wahlestedt C. GABA suppresses stimulation-induced release of [3H]-noradrenaline from sympathetic nerve fibres in bovine ovarian follicles. Journal of Autonomic Pharmacology. 7: 339-47. PMID 3127396  1
1987 Wahlestedt C, Skagerberg G, Ekman R, Heilig M, Sundler F, HÃ¥kanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Research. 417: 33-8. PMID 3040184 DOI: 10.1016/0006-8993(87)90176-4  1
1985 Wahlestedt C, Skagerberg G, HÃ¥kanson R, Sundler F, Wada H, Watanabe T. Spinal projections of hypothalamic histidine decarboxylase-immunoreactive neurones. Agents and Actions. 16: 231-3. PMID 4013912 DOI: 10.1007/BF01983147  1
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