| Year |
Citation |
Score |
| 2016 |
Koen YM, Liu K, Shinogle HE, Williams TD, Hanzlik RP. Comparative Toxicity and Metabolism of N-Acyl Homologs of Acetaminophen and its Isomer 3'-Hydroxyacetanilide. Chemical Research in Toxicology. PMID 27680534 DOI: 10.1021/Acs.Chemrestox.6B00270 |
0.397 |
|
| 2016 |
Koen YM, Galeva NA, Metushi IG, Uetrecht J, Hanzlik RP. Protein targets of isoniazid reactive metabolites in mouse liver in vivo. Chemical Research in Toxicology. PMID 27097313 DOI: 10.1021/Acs.Chemrestox.6B00098 |
0.306 |
|
| 2013 |
Koen YM, Sarma D, Hajovsky H, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP. Protein targets of thioacetamide metabolites in rat hepatocytes. Chemical Research in Toxicology. 26: 564-74. PMID 23465048 DOI: 10.1021/Tx400001X |
0.655 |
|
| 2012 |
Hajovsky H, Hu G, Koen Y, Sarma D, Cui W, Moore DS, Staudinger JL, Hanzlik RP. Metabolism and toxicity of thioacetamide and thioacetamide S-oxide in rat hepatocytes. Chemical Research in Toxicology. 25: 1955-63. PMID 22867114 DOI: 10.1021/Tx3002719 |
0.674 |
|
| 2012 |
Koen YM, Hajovsky H, Liu K, Williams TD, Galeva NA, Staudinger JL, Hanzlik RP. Liver protein targets of hepatotoxic 4-bromophenol metabolites. Chemical Research in Toxicology. 25: 1777-86. PMID 22827705 DOI: 10.1021/Tx3002675 |
0.361 |
|
| 2012 |
Sarma D, Hajovsky H, Koen YM, Galeva NA, Williams TD, Staudinger JL, Hanzlik RP. Covalent modification of lipids and proteins in rat hepatocytes and in vitro by thioacetamide metabolites. Chemical Research in Toxicology. 25: 1868-77. PMID 22667464 DOI: 10.1021/Tx3001658 |
0.68 |
|
| 2012 |
Koen YM, Sarma D, Williams TD, Galeva NA, Obach RS, Hanzlik RP. Identification of protein targets of reactive metabolites of tienilic acid in human hepatocytes. Chemical Research in Toxicology. 25: 1145-54. PMID 22462724 DOI: 10.1021/Tx300103J |
0.618 |
|
| 2011 |
Sarma D, Hanzlik RP. Synthesis of carbon-14, carbon-13 and deuterium labeled forms of thioacetamide and thioacetamide S-oxide. Journal of Labelled Compounds & Radiopharmaceuticals. 54: 795-798. PMID 26069392 DOI: 10.1002/Jlcr.1933 |
0.654 |
|
| 2010 |
Auld DS, Lovell S, Thorne N, Lea WA, Maloney DJ, Shen M, Rai G, Battaile KP, Thomas CJ, Simeonov A, Hanzlik RP, Inglese J. Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124. Proceedings of the National Academy of Sciences of the United States of America. 107: 4878-83. PMID 20194791 DOI: 10.1073/Pnas.0909141107 |
0.34 |
|
| 2009 |
Fang J, Koen YM, Hanzlik RP. Bioinformatic analysis of xenobiotic reactive metabolite target proteins and their interacting partners. Bmc Chemical Biology. 9: 5. PMID 19523227 DOI: 10.1186/1472-6769-9-5 |
0.306 |
|
| 2009 |
Hanzlik RP, Fang J, Koen YM. Filling and mining the reactive metabolite target protein database. Chemico-Biological Interactions. 179: 38-44. PMID 18823962 DOI: 10.1016/J.Cbi.2008.08.016 |
0.305 |
|
| 2008 |
Ikehata K, Duzhak TG, Galeva NA, Ji T, Koen YM, Hanzlik RP. Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo. Chemical Research in Toxicology. 21: 1432-42. PMID 18547066 DOI: 10.1021/Tx800093K |
0.365 |
|
| 2008 |
Huang W, Yamamoto Y, Li Y, Dou D, Alliston KR, Hanzlik RP, Williams TD, Groutas WC. X-ray snapshot of the mechanism of inactivation of human neutrophil elastase by 1,2,5-thiadiazolidin-3-one 1,1-dioxide derivatives. Journal of Medicinal Chemistry. 51: 2003-8. PMID 18318470 DOI: 10.1021/Jm700966P |
0.303 |
|
| 2007 |
Ji T, Ikehata K, Koen YM, Esch SW, Williams TD, Hanzlik RP. Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo. Chemical Research in Toxicology. 20: 701-8. PMID 17381136 DOI: 10.1021/Tx600362H |
0.353 |
|
| 2007 |
Hanzlik RP, Koen YM, Theertham B, Dong Y, Fang J. The reactive metabolite target protein database (TPDB)--a web-accessible resource. Bmc Bioinformatics. 8: 95. PMID 17367530 DOI: 10.1186/1471-2105-8-95 |
0.312 |
|
| 2007 |
Koen YM, Gogichaeva NV, Alterman MA, Hanzlik RP. A proteomic analysis of bromobenzene reactive metabolite targets in rat liver cytosol in vivo. Chemical Research in Toxicology. 20: 511-9. PMID 17305373 DOI: 10.1021/Tx6003166 |
0.337 |
|
| 2006 |
Koen YM, Yue W, Galeva NA, Williams TD, Hanzlik RP. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Chemical Research in Toxicology. 19: 1426-34. PMID 17112229 DOI: 10.1021/Tx060142S |
0.315 |
|
| 2006 |
Cerny MA, Hanzlik RP. Cytochrome P450-catalyzed oxidation of N-benzyl-N-cyclopropylamine generates both cyclopropanone hydrate and 3-hydroxypropionaldehyde via hydrogen abstraction, not single electron transfer. Journal of the American Chemical Society. 128: 3346-54. PMID 16522116 DOI: 10.1021/Ja054938+ |
0.734 |
|
| 2005 |
Cerny MA, Hanzlik RP. Cyclopropylamine inactivation of cytochromes P450: role of metabolic intermediate complexes. Archives of Biochemistry and Biophysics. 436: 265-75. PMID 15797239 DOI: 10.1016/J.Abb.2005.02.020 |
0.743 |
|
| 2004 |
Lucas LH, Cerny MA, Koen YM, Hanzlik RP, Larive CK. 1H high-resolution magic-angle spinning (HR-MAS) NMR analysis of ligand density on resins using a resin internal standard. Analytical and Bioanalytical Chemistry. 380: 627-31. PMID 15480583 DOI: 10.1007/S00216-004-2781-0 |
0.688 |
|
| 2004 |
Totah RA, Hanzlik RP. Oxidative and nonoxidative decarboxylation of N-Alkyl-N-phenylglycines by horseradish peroxidase. Mechanistic switching by varying hydrogen peroxide, oxygen, and solvent deuterium. Biochemistry. 43: 7907-14. PMID 15196035 DOI: 10.1021/Bi049499Q |
0.683 |
|
| 2002 |
Totah RA, Hanzlik RP. Non-oxidative decarboxylation of glycine derivatives by a peroxidase. Journal of the American Chemical Society. 124: 10000-1. PMID 12188659 DOI: 10.1021/Ja020559U |
0.672 |
|
| 2002 |
Koen YM, Hanzlik RP. Identification of seven proteins in the endoplasmic reticulum as targets for reactive metabolites of bromobenzene. Chemical Research in Toxicology. 15: 699-706. PMID 12018992 DOI: 10.1021/Tx0101898 |
0.317 |
|
| 2002 |
Alterman MA, Hanzlik RP. Hydroxylation of fatty acids by microsomal and reconstituted cytochrome P450 2B1. Febs Letters. 512: 319-22. PMID 11852103 DOI: 10.1016/S0014-5793(02)02260-3 |
0.349 |
|
| 2001 |
Totah RA, Hanzlik RP. Detection of aminium ion intermediates: N-cyclopropyl versus N-carboxymethyl groups as reporters. Journal of the American Chemical Society. 123: 10107-8. PMID 11592894 DOI: 10.1021/Ja011648U |
0.626 |
|
| 2001 |
Shaffer CL, Morton MD, Hanzlik RP. N-dealkylation of an N-cyclopropylamine by horseradish peroxidase. Fate of the cyclopropyl group Journal of the American Chemical Society. 123: 8502-8508. PMID 11525657 DOI: 10.1021/Ja0111479 |
0.457 |
|
| 2000 |
Koen YM, Williams TD, Hanzlik RP. Identification of three protein targets for reactive metabolites of bromobenzene in rat liver cytosol Chemical Research in Toxicology. 13: 1326-1335. PMID 11123975 DOI: 10.1021/Tx000165L |
0.355 |
|
| 1999 |
Noble MA, Miles CS, Chapman SK, Lysek DA, MacKay AC, Reid GA, Hanzlik RP, Munro AW. Roles of key active-site residues in flavocytochrome P450 BM3. The Biochemical Journal. 339: 371-9. PMID 10191269 DOI: 10.1042/Bj3390371 |
0.367 |
|
| 1999 |
Rombach EM, Hanzlik RP. Detection of adducts of bromobenzene 3,4-oxide with rat liver microsomal protein sulfhydryl groups using specific antibodies Chemical Research in Toxicology. 12: 159-163. PMID 10027793 DOI: 10.1021/Tx980177V |
0.405 |
|
| 1998 |
Noble MA, Quaroni L, Chumanov GD, Turner KL, Chapman SK, Hanzlik RP, Munro AW. Imidazolyl carboxylic acids as mechanistic probes of flavocytochrome P-450 BM3. Biochemistry. 37: 15799-807. PMID 9843385 DOI: 10.1021/Bi980462D |
0.342 |
|
| 1998 |
Rombach EM, Hanzlik RP. Identification of a rat liver microsomal esterase as a target protein for bromobenzene metabolites Chemical Research in Toxicology. 11: 178-184. PMID 9544615 DOI: 10.1021/Tx970076H |
0.363 |
|
| 1997 |
Rombach EM, Hanzlik RP. Detection of benzoquinone adducts to rat liver protein sulfhydryl groups using specific antibodies Chemical Research in Toxicology. 10: 1407-1411. PMID 9437532 DOI: 10.1021/Tx970130U |
0.331 |
|
| 1997 |
Rietjens IMCM, Besten CD, Hanzlik RP, Van Bladeren PJ. Cytochrome P450-catalyzed oxidation of halobenzene derivatives Chemical Research in Toxicology. 10: 629-635. PMID 9208168 DOI: 10.1021/Tx9601061 |
0.41 |
|
| 1997 |
Lu P, Alterman MA, Chaurasia CS, Bambal RB, Hanzlik RP. Heme-coordinating analogs of lauric acid as inhibitors of fatty acid ω- hydroxylation Archives of Biochemistry and Biophysics. 337: 1-7. PMID 8990261 DOI: 10.1006/Abbi.1996.9768 |
0.347 |
|
| 1996 |
Bambal RB, Hanzlik RP. Effects of steric bulk and conformational rigidity on fatty acid omega hydroxylation by a cytochrome P450 4A1 fusion protein Archives of Biochemistry and Biophysics. 334: 59-66. PMID 8837739 DOI: 10.1006/Abbi.1996.0429 |
0.339 |
|
| 1996 |
Bambal RB, Hanzlik RP. Active site structure and substrate specificity of cytochrome P450 4A1 : Steric control of ligand approach perpendicular to heme plane Biochemical and Biophysical Research Communications. 219: 445-449. PMID 8605007 DOI: 10.1006/Bbrc.1996.0253 |
0.371 |
|
| 1995 |
Chaurasia CS, Alterman MA, Lu P, Hanzlik RP. Biochemical characterization of lauric acid ω-hydroxylation by a CYP4A1/NADPH-cytochrome P450 reductase fusion protein Archives of Biochemistry and Biophysics. 317: 161-169. PMID 7872779 DOI: 10.1006/Abbi.1995.1149 |
0.369 |
|
| 1995 |
Alterman MA, Chaurasia CS, Lu P, Hardwick JP, Hanzlik RP. Fatty acid discrimination and ω-hydroxylation by cytochrome P450 4A1 and a cytochrome P4504A1/NADPH-P450 reductase fusion protein Archives of Biochemistry and Biophysics. 320: 289-296. PMID 7625836 DOI: 10.1016/0003-9861(95)90012-8 |
0.37 |
|
| 1995 |
Rizk PN, Hanzlik RP. Oxidative and non-oxidative metabolism of 4-iodoanisole by rat liver microsomes Xenobiotica. 25: 143-150. PMID 7618342 DOI: 10.3109/00498259509061840 |
0.432 |
|
| 1995 |
Alterman MA, Chaurasia CS, Lu P, Hanzlik RP. Heteroatom substitution shifts regioselectivity of lauric acid metabolism from ω-hydroxylation to (ω-1)-oxidation Biochemical and Biophysical Research Communications. 214: 1089-1094. PMID 7575514 DOI: 10.1006/Bbrc.1995.2397 |
0.39 |
|
| 1995 |
Bambal RB, Hanzlik RP. Bromobenzene 3,4-oxide alkylates histidine and lysine side chains of rat liver proteins in vivo Chemical Research in Toxicology. 8: 729-735. PMID 7548756 DOI: 10.1021/Tx00047A013 |
0.441 |
|
| 1994 |
Hanzlik RP, Harriman SP, Frauenhoff MM. Covalent binding of benzoquinone to reduced ribonuclease. Adduct structures and stoichiometry Chemical Research in Toxicology. 7: 177-184. PMID 8199306 DOI: 10.1021/Tx00038A010 |
0.369 |
|
| 1994 |
Riley P, Hanzlik RP. Electron transfer in p450 mechanisms. Microsomal metabolism of cyclopropylbenzene and p-cyclopropylanisole Xenobiotica. 24: 1-16. PMID 8165817 DOI: 10.3109/00498259409043216 |
0.333 |
|
| 1994 |
Bambal R, Hanzlik RP. Synthesis of N.epsilon.-(p-Bromophenyl)-L-lysine and N.tau.-(p-Bromophenyl)-L-histidine as Models for Adducts of Bromobenzene 3,4-Oxide to Protein. Observation of an Unusual Pd-Catalyzed N.tau. to N.pi.-Aryl Substituent Migration The Journal of Organic Chemistry. 59: 729-732. DOI: 10.1021/Jo00083A011 |
0.373 |
|
| 1993 |
Slaughter DE, Zheng J, Harriman S, Hanzlik RP. Identification of covalent adducts to protein sulfur nucleophiles by alkaline permethylation Analytical Biochemistry. 208: 288-295. PMID 8452222 DOI: 10.1006/Abio.1993.1048 |
0.355 |
|
| 1993 |
Fisher R, Brendel K, Hanzlik RP. Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro Chemico-Biological Interactions. 88: 191-208. PMID 8403079 DOI: 10.1016/0009-2797(93)90091-C |
0.34 |
|
| 1993 |
Hanzlik RP, Ling KHJ. Active site dynamics of xylene hydroxylation by cytochrome P-450 as revealed by kinetic deuterium isotope effects Journal of the American Chemical Society. 115. DOI: 10.1021/Ja00074A001 |
0.348 |
|
| 1992 |
Zheng J, Hanzlik RP. Dihydroxylated mercapturic acid metabolites of bromobenzene Chemical Research in Toxicolgy. 5: 561-567. PMID 1391623 DOI: 10.1021/Tx00028A016 |
0.35 |
|
| 1991 |
Hanzlik RP, Jacober SP, Zygmunt J. Reversible binding of peptide aldehydes to papain. Structure-activity relationships Bba - General Subjects. 1073: 33-42. PMID 1991144 DOI: 10.1016/0304-4165(91)90179-K |
0.331 |
|
| 1991 |
Slaughter DE, Hanzlik RP. Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles Chemical Research in Toxicology. 4: 349-359. PMID 1912319 DOI: 10.1021/Tx00021A015 |
0.412 |
|
| 1991 |
Zheng J, Hanzlik RP. Premercapturic acid metabolites of bromobenzene derived via its 2,3- and 3,4-oxide metabolites Xenobiotica. 21: 535-546. PMID 1897252 DOI: 10.3109/00498259109039493 |
0.316 |
|
| 1991 |
Hall LR, Hanzlik RP. N-dealkylation of tertiary amides by cytochrome p-450 Xenobiotica. 21: 1127-1138. PMID 1788981 DOI: 10.3109/00498259109039553 |
0.398 |
|
| 1990 |
Hanzlik RP, Ling KHJ. Active site dynamics of toluene hydroxylation by cytochrome P-450 Journal of Organic Chemistry. 55: 3992-3997. DOI: 10.1021/Jo00300A010 |
0.332 |
|
| 1990 |
Hanzlik RP, Weller PE, Desai J, Zheng J, Hall LR, Slaughter DE. Synthesis of mercapturic acid derivatives of putative toxic metabolites of bromobenzene Journal of Organic Chemistry. 55: 2736-2742. DOI: 10.1021/Jo00296A034 |
0.314 |
|
| 1989 |
Ling KHJ, Hanzlik RP. Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysis Biochemical and Biophysical Research Communications. 160: 844-849. PMID 2719701 DOI: 10.1016/0006-291X(89)92511-4 |
0.313 |
|
| 1989 |
Hall LR, Iwamoto RT, Hanzlik RP. Electrochemical models for cytochrome P-450. N-demethylation of tertiary amides by anodic oxidation Journal of Organic Chemistry. 54: 2446-2451. DOI: 10.1021/Jo00271A040 |
0.355 |
|
| 1989 |
Riley P, Hanzlik RP. Free radical chlorination and one-electron oxidation of arylcyclopropanes. Designer probes for cytochrome P-450 hydroxylation mechanisms Tetrahedron Letters. 30: 3015-3018. DOI: 10.1016/S0040-4039(00)99390-0 |
0.366 |
|
| 1988 |
Buben JA, Narasimhan N, Hanzlik RP. Effects of chemical and enzymic probes on microsomal covalent binding of bromobenzene and derivatives. Evidence for quinones as reactive metabolites Xenobiotica. 18: 501-510. PMID 3400272 DOI: 10.3109/00498258809041687 |
0.361 |
|
| 1988 |
Narasimhan N, Weller PE, Buben JA, Wiley RA, Hanzlik RP. Microsomal metabolism and covalent binding of [3h/14c]-bromobenzene. Evidence for quinones as reactive metabolites Xenobiotica. 18: 491-499. PMID 3400271 DOI: 10.3109/00498258809041686 |
0.35 |
|
| 1987 |
Cox DN, Traiger GJ, Jacober SP, Hanzlik RP. Comparison of the toxicity of methylcyclopentadienyl manganese tricarbonyl with that of its two major metabolites. Toxicology Letters. 39: 1-5. PMID 3672550 DOI: 10.1016/0378-4274(87)90250-5 |
0.336 |
|
| 1987 |
Hanzlik RP, Schaefer AR, Moon JB, Judson CM. Primary and secondary kinetic deuterium isotope effects and transition-state structures for benzylic chlorination and bromination of toluene Journal of the American Chemical Society. 109: 4926-4930. DOI: 10.1021/Ja00250A028 |
0.301 |
|
| 1986 |
Thompson SA, Andrews PR, Hanzlik RP. Carboxyl-modified amino acids and peptides as protease inhibitors Journal of Medicinal Chemistry. 29: 104-111. PMID 3941405 DOI: 10.1002/Chin.198620345 |
0.323 |
|
| 1986 |
Hanzlik RP. Chemistry of covalent binding: studies with bromobenzene and thiobenzamide Advances in Experimental Medicine and Biology. 197: 31-40. PMID 3766265 DOI: 10.1007/978-1-4684-5134-4_3 |
0.314 |
|
| 1986 |
Jacober SP, Hanzlik RP. Carbon-13 and oxygen-18 kinetic isotope effects on methanolysis of p-nitrostyrene oxide Journal of the American Chemical Society. 108: 1594-1597. DOI: 10.1021/Ja00267A033 |
0.312 |
|
| 1985 |
Penney DA, Gottschall DW, Hanzlik RP, Traiger GJ. The role of metabolism in N-methylthiobenzamide-induced pneumotoxicity Toxicology and Applied Pharmacology. 78: 323-331. PMID 3931298 DOI: 10.1016/0041-008X(85)90237-6 |
0.341 |
|
| 1985 |
Gottschall DW, Penney DA, Traiger GJ, Hanzlik RP. Oxidation of N-methylthiobenzamide and N-methylthiobenzamide S-oxide by liver and lung microsomes Toxicology and Applied Pharmacology. 78: 332-341. PMID 2996173 DOI: 10.1016/0041-008X(85)90238-8 |
0.443 |
|
| 1985 |
Traiger GJ, Vyas KP, Hanzlik RP. Effect of inhibitors of α-naphthylisothiocyanate-induced hepatotoxicity on the in vitro metabolism of α-naphthylisothiocyanate Chemico-Biological Interactions. 52: 335-345. PMID 2982508 DOI: 10.1016/0009-2797(85)90028-6 |
0.373 |
|
| 1984 |
Gottschall DW, Harder RR, Wiley RA, Hanzlik RP. Chemical models for toxic metabolites of bromobenzene derivatives. Relative toxicity toward isolated hepatocytes Toxicology. 31: 251-259. PMID 6740700 DOI: 10.1016/0300-483X(84)90106-9 |
0.317 |
|
| 1984 |
Hanzlik RP, Hogberg K, Judson CM. Microsomal hydroxylation of specifically deuterated monosubstituted benzenes. Evidence for direct aromatic hydroxylation Biochemistry. 23: 3048-3055. PMID 6466630 DOI: 10.1021/Bi00308A031 |
0.362 |
|
| 1984 |
Traiger GJ, Vyas KP, Hanzlik RP. Effect of thiocarbonyl compounds on α-naphthylisothiocyanate-induced hepatotoxicity and the urinary excretion of [35S]α-naphthylisothiocyanate in the rat Toxicology and Applied Pharmacology. 72: 504-512. PMID 6324415 DOI: 10.1016/0041-008X(84)90127-3 |
0.305 |
|
| 1983 |
Cashman JR, Parikh KK, Traiger GJ, Hanzlik RP. Relative hepatotoxicity of ortho and meta mono substituted thiobenzamides in the rat Chemico-Biological Interactions. 45: 341-347. PMID 6883575 DOI: 10.1016/0009-2797(83)90080-7 |
0.338 |
|
| 1982 |
Cashman JR, Traiger GJ, Hanzlik RP. Pneumotoxic effects of thiobenzamide derivatives Toxicology. 23: 85-93. PMID 7089987 DOI: 10.1016/0300-483X(82)90044-0 |
0.337 |
|
| 1982 |
Hanzlik RP. Effects of substituents on reactivity and toxicity of chemically reactive intermediates Drug Metabolism Reviews. 13: 207-234. PMID 7047127 DOI: 10.3109/03602538209029997 |
0.302 |
|
| 1982 |
Cashman JR, Hanzlik RP. Oxidation and other reactions of thiobenzamide derivatives of relevance to their hepatotoxicity Journal of Organic Chemistry. 47: 4645-4650. DOI: 10.1021/Jo00145A008 |
0.377 |
|
| 1981 |
Hanzlik RP, Gillesse TJ, Wiley RA. Toxicity and covalent binding of substituted bromobenzenes to isolated hepatocytes Advances in Experimental Medicine and Biology. 136: 381-386. PMID 7344469 DOI: 10.1007/978-1-4757-0674-1_26 |
0.35 |
|
| 1981 |
Hanzlik RP, Bhatia P. Metabolism of azulene in rats Xenobiotica. 11: 779-783. PMID 7336759 DOI: 10.3109/00498258109045882 |
0.344 |
|
| 1981 |
Westkaemper RB, Hanzlik RP. Mechanistic studies of epoxide hydrolase utilizing a continuous spectophotometric assay Archives of Biochemistry and Biophysics. 208: 195-204. PMID 7259178 DOI: 10.1016/0003-9861(81)90140-5 |
0.318 |
|
| 1981 |
Cashman JR, Hanzlik RP. Microsomal oxidation of thiobenzamide. A photometric assay for the flavin-containing monooxygenase Biochemical and Biophysical Research Communications. 98: 147-153. PMID 7213381 DOI: 10.1016/0006-291X(81)91881-7 |
0.439 |
|
| 1980 |
Hanzlik RP, Cashman JR, Traiger GJ. Relative hepatotoxicity of substituted thiobenzamides and thiobenzamide-S-oxides in the rat Toxicology and Applied Pharmacology. 55: 260-272. PMID 7423516 DOI: 10.1016/0041-008X(80)90088-5 |
0.392 |
|
| 1980 |
Westkaemper RB, Hanzlik RP. A convenient reverse-phase liquid chromatographic assay for epoxide hydrase Analytical Biochemistry. 102: 63-67. PMID 7356165 DOI: 10.1016/0003-2697(80)90317-6 |
0.34 |
|
| 1980 |
Hanzlik RP, Walsh JS. Halogenated epoxides and related compounds as inhibitors of epoxide hydrase Archives of Biochemistry and Biophysics. 204: 255-263. PMID 7191695 DOI: 10.1016/0003-9861(80)90031-4 |
0.427 |
|
| 1980 |
Hanzlik RP, Westkaemper RB. Secondary deuterium isotope effects on epoxide methanolysis reactions Journal of the American Chemical Society. 102: 2464-2467. DOI: 10.1021/Ja00527A060 |
0.311 |
|
| 1980 |
Wiley RA, Hanzlik RP, Gillesse T. Substituent Effects On Toxicity And Covalent Binding Of Bromobenzene Derivatives Microsomes, Drug Oxidations and Chemical Carcinogenesis. 921-924. DOI: 10.1016/B978-0-12-187702-6.50063-3 |
0.318 |
|
| 1980 |
Hanzlik RP, Tullman RH, Kishore V. Inactivation Of Cytochrome P-450 Enzymes By Cyclopropylamines Microsomes, Drug Oxidations and Chemical Carcinogenesis. 327-330. DOI: 10.1016/B978-0-12-187701-9.50062-0 |
0.38 |
|
| 1979 |
Hanzlik RP, Eric Harkness C, Arnoldi S. Gas chromatographic determination of methylcyclopen- tadienylmanganesetricarbonyl in biological tissues and fluids Journal of Chromatography A. 171: 279-283. PMID 546853 DOI: 10.1016/S0021-9673(01)95307-5 |
0.32 |
|
| 1979 |
Wiley RA, Hanzlik RP, Gillesse T. Effect of substituents on in vitro metabolism and covalent binding of substituted bromobenzenes Toxicology and Applied Pharmacology. 49: 249-255. PMID 494276 DOI: 10.1016/0041-008X(79)90248-5 |
0.342 |
|
| 1979 |
Hanzlik RP, Soine P, Soine WH. Biological properties of transition-metal organometallic compounds. 3. β-ferrocenylalanine Journal of Medicinal Chemistry. 22: 424-428. PMID 430480 DOI: 10.1021/Jm00190A013 |
0.309 |
|
| 1979 |
Hanzlik RP, Wiley RA, Gillesse TJ. Tritium and deuterium exchange labeling of aromatic and organometallic compounds in heptafluorobutyric acid Journal of Labelled Compounds and Radiopharmaceuticals. 16: 523-529. DOI: 10.1002/Jlcr.2580160403 |
0.316 |
|
| 1978 |
Hanzlik RP, Vyas KP, Traiger GJ. Substituent effects on the hepatotoxicity of thiobenzamide derivatives in the rat Toxicology and Applied Pharmacology. 46: 685-694. PMID 746555 DOI: 10.1016/0041-008X(78)90313-7 |
0.317 |
|
| 1978 |
Hanzlik RP, Shearer GO. Secondary deuterium isotope effects on olefin epoxidation by cytochrome P-450 Biochemical Pharmacology. 27: 1441-1444. PMID 697886 DOI: 10.1016/0006-2952(78)90099-0 |
0.361 |
|
| 1978 |
Hanzlik RP, Shearer GO, Hamburg A, Gillesse T. Metabolism in vitro of para-substituted styrenes. Kinetic observations of substituent effects Biochemical Pharmacology. 27: 1435-1439. PMID 697885 DOI: 10.1016/0006-2952(78)90098-9 |
0.379 |
|
| 1978 |
Hanzlik RP, Heideman S, Smith D. Regioselectivity in enzymatic hydration of cis-1,2-disubstituted [18O]-epoxides Biochemical and Biophysical Research Communications. 82: 310-315. PMID 666904 DOI: 10.1016/0006-291X(78)90610-1 |
0.344 |
|
| 1977 |
Toranzo EG, Gillesse T, Mendenhall M, Traiger GJ, Riley PG, Hanzlik RP, Wiley RA. Effect of substituents on arene oxide-mediated liver toxicity among substituted bromobenzenes. Toxicology and Applied Pharmacology. 40: 415-25. PMID 882979 DOI: 10.1016/0041-008X(77)90069-2 |
0.304 |
|
| 1976 |
Hanzlik RP, Edelman M, Michaely WJ, Scott G. Enzymatic hydration of [18O]epoxides. Role of nucleophilic mechanisms Journal of the American Chemical Society. 98: 1952-1955. PMID 1254854 DOI: 10.1021/Ja00423A050 |
0.328 |
|
| 1976 |
Hanzlik RP, Williamson D. Oxygen activation by transition metal complexes. 2. Bis(acetylacetonato)cobalt(II)-catalyzed oxidation of tributylphosphine Journal of the American Chemical Society. 98: 6570-6573. DOI: 10.1021/Ja00437A026 |
0.391 |
|
| 1970 |
van Tamelen EE, Hanzlik RP, Clayton RB, Burlingame AL. Minimal substrate structural requirements for lanosterol-squalene 2,3-oxide cyclase action. 10'-norsqualene 2,3-oxide. Journal of the American Chemical Society. 92: 2137-9. PMID 5435278 DOI: 10.1021/ja00710a060 |
0.716 |
|
| 1970 |
Van Tamelen EE, Hanzlik RP, Clayton RB, Burlingame AL. Minimal substrate structural requirements for lanosterol-squalene 2,3-oxide cyclase action. 10′-norsqualene 2,3-oxide [6] Journal of the American Chemical Society. 92: 2137-2139. |
0.561 |
|
| 1969 |
Anderson RJ, Hanzlik RP, Sharpless KB, Van Tamelen EE, Clayton RB. Enzymic transformation of an acyclic sesterterpene terminal epoxide into a lanosterol analogue Journal of the Chemical Society D: Chemical Communications. 53-54. DOI: 10.1039/C29690000053 |
0.709 |
|
| 1968 |
Van Tamelen EE, Hanzlik RP, Sharpless KB, Clayton RB, Richter WJ, Burlingame AL. Enzymic cyclization of 15-norsqualene 2,3-oxide Journal of the American Chemical Society. 90: 3284-3286. DOI: 10.1021/Ja01014A081 |
0.708 |
|
| 1968 |
Sharpless KB, Hanzlik RP, Van Tamelen EE. One-step synthesis of 1,5-dienes involving reductive coupling of allyl alcohols Journal of the American Chemical Society. 90: 209-210. DOI: 10.1021/ja01003a037 |
0.356 |
|
| 1968 |
Sharples KB, Hanzlik RP, Van Tamelen EE. A one-step synthesis of 1,5-dienes involving reductive coupling of allyl alcohols [2] Journal of the American Chemical Society. 90: 209-210. |
0.457 |
|
| 1968 |
Van Tamelen EE, Hanzlik RP, Sharpless KB, Clayton RB, Richter WJ, Burlingame AL. Enzymic cyclization of 15-norsqualene 2,3-oxide [38] Journal of the American Chemical Society. 90: 3284-3286. |
0.579 |
|
| 1967 |
van Tamelen EE, Sharpless KB, Hanzlik R, Clayton RB, Burlingame AL, Wszolek PC. Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. Journal of the American Chemical Society. 89: 7150-1. PMID 6064361 DOI: 10.1021/Ja01002A077 |
0.748 |
|
| 1967 |
Van Tamelen EE, Sharpless KB, Hanzlik R, Clayton RB, Burlingame AL, Wszolek PC. Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide [32] Journal of the American Chemical Society. 89: 7150-7151. |
0.577 |
|
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