Paul A. Slesinger - Publications

Affiliations: 
The Salk Institute 
 Neurosciences University of California, San Diego, La Jolla, CA 
Area:
GIRK channels, addiction, plasticity, G proteins

89 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mathiharan YK, Glaaser IW, Zhao Y, Robertson MJ, Skiniotis G, Slesinger PA. Structural insights into GIRK2 channel modulation by cholesterol and PIP. Cell Reports. 36: 109619. PMID 34433062 DOI: 10.1016/j.celrep.2021.109619  0.644
2021 Foo C, Lozada A, Aljadeff J, Li Y, Wang JW, Slesinger PA, Kleinfeld D. Reinforcement learning links spontaneous cortical dopamine impulses to reward. Current Biology : Cb. PMID 34302743 DOI: 10.1016/j.cub.2021.06.069  0.466
2021 Zhao Y, Gameiro-Ros I, Glaaser IW, Slesinger PA. Advances in Targeting GIRK Channels in Disease. Trends in Pharmacological Sciences. 42: 203-215. PMID 33468322 DOI: 10.1016/j.tips.2020.12.002  0.66
2020 Wang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang YS, ... ... Slesinger PA, et al. Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer's Disease. Neuron. PMID 33238137 DOI: 10.1016/j.neuron.2020.11.002  0.769
2020 Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, ... ... Slesinger PA, et al. Structure of human GABA receptor in an inactive state. Nature. PMID 32581365 DOI: 10.1038/S41586-020-2452-0  0.371
2020 Zhao Y, Ung PM, Zahoránszky-Kőhalmi G, Zakharov AV, Martinez NJ, Simeonov A, Glaaser IW, Rai G, Schlessinger A, Marugan JJ, Slesinger PA. Identification of a G-Protein-Independent Activator of GIRK Channels. Cell Reports. 31: 107770. PMID 32553165 DOI: 10.1016/J.Celrep.2020.107770  0.728
2020 Li X, Terunuma M, Deeb TG, Wiseman S, Pangalos MN, Nairn AC, Moss SJ, Slesinger PA. Direct interaction of PP2A phosphatase with GABA receptors alters functional signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 32111696 DOI: 10.1523/Jneurosci.2654-19.2020  0.451
2020 Barretto N, Zhang H, Powell SK, Fernando MB, Zhang S, Flaherty EK, Ho SM, Slesinger PA, Duan J, Brennand KJ. ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs. Journal of Neuroscience Methods. 334: 108548. PMID 32065989 DOI: 10.1016/J.Jneumeth.2019.108548  0.767
2020 Glaaser IW, Mathiharan YK, Zhao Y, Skiniotis G, Slesinger PA. CRYO-EM Structures of the GIRK2 Channel Reveal Mechanisms for Lipid Modulation Biophysical Journal. 118: 497a-498a. DOI: 10.1016/J.Bpj.2019.11.2749  0.405
2019 Zuo H, Glaaser I, Zhao Y, Kurinov I, Mosyak L, Wang H, Liu J, Park J, Frangaj A, Sturchler E, Zhou M, McDonald P, Geng Y, Slesinger PA, Fan QR. Structural basis for auxiliary subunit KCTD16 regulation of the GABA receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 30971491 DOI: 10.1073/Pnas.1903024116  0.659
2019 Adelman JP, Clapham DE, Hibino H, Inanobe A, Jan LY, Karschin A, Kubo Y, Kurachi Y, Lazdunski M, Miki T, Nichols CG, Palmer LG, Pearson WL, Sackin H, Seino S, ... Slesinger PA, et al. Inwardly rectifying potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f74/2019.4  0.55
2018 Rifkin RA, Huyghe D, Li X, Parakala M, Aisenberg E, Moss SJ, Slesinger PA. GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization. Proceedings of the National Academy of Sciences of the United States of America. PMID 30228121 DOI: 10.1073/Pnas.1807788115  0.419
2018 Horvath GA, Zhao Y, Tarailo-Graovac M, Boelman C, Gill H, Shyr C, Lee J, Blydt-Hansen I, Drögemöller BI, Moreland J, Ross CJ, Wasserman WW, Masotti A, Slesinger PA, Karnebeek CDMV. Gain-of-function KCNJ6 mutation in a severe hyperkinetic movement disorder phenotype. Neuroscience. PMID 29852244 DOI: 10.1016/J.Neuroscience.2018.05.031  0.676
2018 Slesinger PA. Insights into Gating of GIRK (KIR3) Channels through G Protein-Independent Pathways Biophysical Journal. 114: 35a. DOI: 10.1016/J.Bpj.2017.11.248  0.48
2017 Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28757165 DOI: 10.1016/J.Stemcr.2017.06.018  0.564
2017 Lacin E, Aryal P, Glaaser IW, Bodhinathan K, Tsai E, Marsh N, Tucker SJ, Sansom MSP, Slesinger PA. Dynamic role of the tether helix in PIP2-dependent gating of a G protein-gated potassium channel. The Journal of General Physiology. PMID 28720589 DOI: 10.1085/Jgp.201711801  0.823
2017 Glaaser IW, Slesinger PA. Dual activation of neuronal G protein-gated inwardly rectifying potassium (GIRK) channels by cholesterol and alcohol. Scientific Reports. 7: 4592. PMID 28676630 DOI: 10.1038/S41598-017-04681-X  0.536
2017 Rifkin RA, Moss SJ, Slesinger PA. G Protein-Gated Potassium Channels: A Link to Drug Addiction. Trends in Pharmacological Sciences. PMID 28188005 DOI: 10.1016/J.Tips.2017.01.007  0.476
2017 Glaaser IW, Slesinger PA. Small Molecule Modulation of Brain GIRK Channels Biophysical Journal. 112: 182a-183a. DOI: 10.1016/J.Bpj.2016.11.1012  0.519
2016 Lacin E, Muller A, Fernando M, Kleinfeld D, Slesinger PA. Construction of Cell-based Neurotransmitter Fluorescent Engineered Reporters (CNiFERs) for Optical Detection of Neurotransmitters In Vivo. Journal of Visualized Experiments : Jove. PMID 27214050 DOI: 10.3791/53290  0.575
2016 Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA. A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 3106-14. PMID 26985023 DOI: 10.1523/Jneurosci.1327-15.2016  0.793
2015 Ho SM, Hartley BJ, Tcw J, Beaumont M, Stafford K, Slesinger PA, Brennand KJ. Rapid Ngn2-induction of Excitatory Neurons from hiPSC-Derived Neural Progenitor Cells. Methods (San Diego, Calif.). PMID 26626326 DOI: 10.1016/J.Ymeth.2015.11.019  0.597
2015 Glaaser IW, Slesinger PA. Structural Insights into GIRK Channel Function. International Review of Neurobiology. 123: 117-60. PMID 26422984 DOI: 10.1016/Bs.Irn.2015.05.014  0.502
2015 Herman MA, Sidhu H, Stouffer DG, Kreifeldt M, Le D, Cates-Gatto C, Munoz MB, Roberts AJ, Parsons LH, Roberto M, Wickman K, Slesinger PA, Contet C. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol. Proceedings of the National Academy of Sciences of the United States of America. 112: 7091-6. PMID 25964320 DOI: 10.1073/Pnas.1416146112  0.768
2015 Kotecki L, Hearing M, McCall NM, Marron Fernandez de Velasco E, Pravetoni M, Arora D, Victoria NC, Munoz MB, Xia Z, Slesinger PA, Weaver CD, Wickman K. GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 7131-42. PMID 25948263 DOI: 10.1523/Jneurosci.5051-14.2015  0.814
2015 Huynh TG, Cuny H, Slesinger PA, Adams DJ. Novel mechanism of voltage-gated N-type (Cav2.2) calcium channel inhibition revealed through α-conotoxin Vc1.1 activation of the GABA(B) receptor. Molecular Pharmacology. 87: 240-50. PMID 25425625 DOI: 10.1124/Mol.114.096156  0.561
2015 Kotecki L, Hearing M, McCall NM, de Velasco EMF, Pravetoni M, Arora D, Victoria NC, Munoz MB, Xia Z, Slesinger PA, Weaver CD, Wickman K. GIRK channels modulate opioid-induced motor activity in a cell type- and subunit-dependent manner Journal of Neuroscience. 35: 7131-7142. DOI: 10.1523/JNEUROSCI.5051-14.2015  0.77
2015 Glaaser IW, Marsh NO, Choe S, Slesinger PA. Alcohol Inhibition of a Chemically-Activated GIRK2 Channel Biophysical Journal. 108: 367a. DOI: 10.1016/J.Bpj.2014.11.2013  0.484
2014 Muller A, Joseph V, Slesinger PA, Kleinfeld D. Cell-based reporters reveal in vivo dynamics of dopamine and norepinephrine release in murine cortex. Nature Methods. 11: 1245-52. PMID 25344639 DOI: 10.1038/Nmeth.3151  0.657
2014 Munoz MB, Slesinger PA. Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response. Neuron. 82: 659-69. PMID 24811384 DOI: 10.1016/J.Neuron.2014.03.011  0.807
2014 Lalive AL, Munoz MB, Bellone C, Slesinger PA, Lüscher C, Tan KR. Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5107-14. PMID 24719090 DOI: 10.1523/Jneurosci.5203-13.2014  0.812
2014 Bodhinathan K, Slesinger PA. Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics. Frontiers in Physiology. 5: 76. PMID 24611054 DOI: 10.3389/Fphys.2014.00076  0.792
2013 Bodhinathan K, Slesinger PA. Molecular mechanism underlying ethanol activation of G-protein-gated inwardly rectifying potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 18309-14. PMID 24145411 DOI: 10.1073/Pnas.1311406110  0.794
2013 Kang JY, Kawaguchi D, Coin I, Xiang Z, O'Leary DD, Slesinger PA, Wang L. In vivo expression of a light-activatable potassium channel using unnatural amino acids. Neuron. 80: 358-70. PMID 24139041 DOI: 10.1016/J.Neuron.2013.08.016  0.467
2013 Balana B, Bahima L, Bodhinathan K, Taura JJ, Taylor NM, Nettleton MY, Ciruela F, Slesinger PA. Ras-association domain of sorting Nexin 27 is critical for regulating expression of GIRK potassium channels. Plos One. 8: e59800. PMID 23536889 DOI: 10.1371/Journal.Pone.0059800  0.798
2013 Bodhinathan K, Slesinger PA. Dissecting Gating Rules of GIRK Channels: Role of PIP2 in Ethanol-Dependent Activation Biophysical Journal. 104: 130a. DOI: 10.1016/J.Bpj.2012.11.744  0.804
2012 Klammt C, Maslennikov I, Bayrhuber M, Eichmann C, Vajpai N, Chiu EJ, Blain KY, Esquivies L, Kwon JH, Balana B, Pieper U, Sali A, Slesinger PA, Kwiatkowski W, Riek R, et al. Facile backbone structure determination of human membrane proteins by NMR spectroscopy. Nature Methods. 9: 834-9. PMID 22609626 DOI: 10.1038/Nmeth.2033  0.717
2012 Padgett CL, Lalive AL, Tan KR, Terunuma M, Munoz MB, Pangalos MN, Martínez-Hernández J, Watanabe M, Moss SJ, Luján R, Lüscher C, Slesinger PA. Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron. 73: 978-89. PMID 22405207 DOI: 10.1016/J.Neuron.2011.12.031  0.772
2012 Bodhinathan K, Slesinger PA. Engineering the Alcohol Pocket to Create a Chemically-Activated GIRK Channel Biophysical Journal. 102: 537a. DOI: 10.1016/J.Bpj.2011.11.2937  0.788
2012 Balana B, Bahima L, Bodhinathan K, Taylor NM, Nettleton MY, Ciruela F, Slesinger PA. Ras-Associated (RA) Domain of Sorting Nexin 27 (SNX27) is Critical for Regulating GIRK Channels Biophysical Journal. 102: 537a. DOI: 10.1016/J.Bpj.2011.11.2936  0.781
2011 Laviv T, Vertkin I, Berdichevsky Y, Fogel H, Riven I, Bettler B, Slesinger PA, Slutsky I. Compartmentalization of the GABAB receptor signaling complex is required for presynaptic inhibition at hippocampal synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 12523-32. PMID 21880914 DOI: 10.1523/Jneurosci.1527-11.2011  0.409
2011 Howard RJ, Slesinger PA, Davies DL, Das J, Trudell JR, Harris RA. Alcohol-binding sites in distinct brain proteins: the quest for atomic level resolution. Alcoholism, Clinical and Experimental Research. 35: 1561-73. PMID 21676006 DOI: 10.1111/J.1530-0277.2011.01502.X  0.356
2011 Hurtado de Mendoza T, Balana B, Slesinger PA, Verma IM. Organotypic cerebellar cultures: apoptotic challenges and detection. Journal of Visualized Experiments : Jove. PMID 21633327 DOI: 10.3791/2564  0.713
2011 Balana B, Maslennikov I, Kwiatkowski W, Stern KM, Bahima L, Choe S, Slesinger PA. Mechanism underlying selective regulation of G protein-gated inwardly rectifying potassium channels by the psychostimulant-sensitive sorting nexin 27. Proceedings of the National Academy of Sciences of the United States of America. 108: 5831-6. PMID 21422294 DOI: 10.1073/Pnas.1018645108  0.805
2010 Balana B, Taylor N, Slesinger PA. Mutagenesis and functional analysis of ion channels heterologously expressed in mammalian cells. Journal of Visualized Experiments : Jove. PMID 20972402 DOI: 10.3791/2189  0.799
2010 Nassirpour R, Bahima L, Lalive AL, Lüscher C, Luján R, Slesinger PA. Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13419-30. PMID 20926668 DOI: 10.1523/Jneurosci.2966-10.2010  0.794
2010 Boyer SB, Slesinger PA. Probing novel GPCR interactions using a combination of FRET and TIRF. Communicative & Integrative Biology. 3: 343-6. PMID 20798821 DOI: 10.4161/Cib.3.4.11764  0.779
2010 Laviv T, Riven I, Dolev I, Vertkin I, Balana B, Slesinger PA, Slutsky I. Basal GABA regulates GABA(B)R conformation and release probability at single hippocampal synapses. Neuron. 67: 253-67. PMID 20670833 DOI: 10.1016/J.Neuron.2010.06.022  0.74
2010 Padgett CL, Slesinger PA. GABAB receptor coupling to G-proteins and ion channels. Advances in Pharmacology (San Diego, Calif.). 58: 123-47. PMID 20655481 DOI: 10.1016/S1054-3589(10)58006-2  0.812
2010 Lüscher C, Slesinger PA. Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. Nature Reviews. Neuroscience. 11: 301-15. PMID 20389305 DOI: 10.1038/Nrn2834  0.527
2010 Aryal P, Dvir H, Choe S, Slesinger PA. Identification of the Alcohol Activation Site in GIRK Channels Biophysical Journal. 98: 700a. DOI: 10.1016/J.Bpj.2009.12.3840  0.729
2009 Boyer SB, Clancy SM, Terunuma M, Revilla-Sanchez R, Thomas SM, Moss SJ, Slesinger PA. Direct interaction of GABAB receptors with M2 muscarinic receptors enhances muscarinic signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 15796-809. PMID 20016095 DOI: 10.1523/Jneurosci.4103-09.2009  0.779
2009 Aryal P, Dvir H, Choe S, Slesinger PA. A discrete alcohol pocket involved in GIRK channel activation. Nature Neuroscience. 12: 988-95. PMID 19561601 DOI: 10.1038/Nn.2358  0.708
2009 Boyer SB, Slesinger PA, Jones SV. Regulation of Kir2.1 channels by the Rho-GTPase, Rac1. Journal of Cellular Physiology. 218: 385-93. PMID 18932198 DOI: 10.1002/Jcp.21610  0.823
2009 Balana B, Maslennikov I, Thomas SM, Tan J, Kwiatkowski W, Choe S, Slesinger PA. Unique Role For The -5′ Position In The Carboxyl Terminus Of GIRK3 Channel In Determining Binding Specificity To The PDZ Domain Of Sorting Nexin 27 Biophysical Journal. 96: 464a-465a. DOI: 10.1016/J.Bpj.2008.12.2392  0.734
2009 Aryal P, Dvir H, Choe S, Slesinger PA. Evidence for a Discrete Alcohol Pocket Mediating GIRK Channel Activation Biophysical Journal. 96: 463a. DOI: 10.1016/J.Bpj.2008.12.2387  0.729
2008 Lomazzi M, Slesinger PA, Lüscher C. Addictive drugs modulate GIRK-channel signaling by regulating RGS proteins. Trends in Pharmacological Sciences. 29: 544-9. PMID 18790542 DOI: 10.1016/J.Tips.2008.07.011  0.499
2007 Nassirpour R, Slesinger PA. Subunit-specific regulation of Kir3 channels by sorting nexin 27. Channels (Austin, Tex.). 1: 331-3. PMID 18690037 DOI: 10.4161/Chan.5191  0.825
2007 Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Lüscher C. RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nature Neuroscience. 10: 1559-68. PMID 17965710 DOI: 10.1038/Nn2006  0.823
2007 Lunn ML, Nassirpour R, Arrabit C, Tan J, McLeod I, Arias CM, Sawchenko PE, Yates JR, Slesinger PA. A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. Nature Neuroscience. 10: 1249-59. PMID 17828261 DOI: 10.1038/Nn1953  0.826
2007 Kurata HT, Cheng WW, Arrabit C, Slesinger PA, Nichols CG. The role of the cytoplasmic pore in inward rectification of Kir2.1 channels. The Journal of General Physiology. 130: 145-55. PMID 17635958 DOI: 10.1085/Jgp.200709742  0.382
2007 Wang W, Takimoto JK, Louie GV, Baiga TJ, Noel JP, Lee KF, Slesinger PA, Wang L. Genetically encoding unnatural amino acids for cellular and neuronal studies. Nature Neuroscience. 10: 1063-72. PMID 17603477 DOI: 10.1038/Nn1932  0.336
2007 Clancy SM, Boyer SB, Slesinger PA. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6388-99. PMID 17567799 DOI: 10.1523/Jneurosci.1190-07.2007  0.822
2007 Pegan S, Tan J, Huang A, Slesinger PA, Riek R, Choe S. NMR studies of interactions between C-terminal tail of Kir2.1 channel and PDZ1,2 domains of PSD95. Biochemistry. 46: 5315-22. PMID 17437338 DOI: 10.1021/Bi062228Q  0.416
2007 Fowler CE, Aryal P, Suen KF, Slesinger PA. Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. The Journal of Physiology. 580: 51-65. PMID 17185339 DOI: 10.1113/Jphysiol.2006.123216  0.685
2006 Pegan S, Arrabit C, Slesinger PA, Choe S. Andersen's syndrome mutation effects on the structure and assembly of the cytoplasmic domains of Kir2.1. Biochemistry. 45: 8599-606. PMID 16834334 DOI: 10.1021/Bi060653D  0.436
2005 Mutneja M, Berton F, Suen KF, Lüscher C, Slesinger PA. Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells. Pflã¼Gers Archiv : European Journal of Physiology. 450: 61-73. PMID 15806402 DOI: 10.1007/S00424-004-1367-1  0.811
2005 Pegan S, Arrabit C, Zhou W, Kwiatkowski W, Collins A, Slesinger PA, Choe S. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nature Neuroscience. 8: 279-87. PMID 15723059 DOI: 10.1038/Nn1411  0.441
2005 Clancy SM, Fowler CE, Finley M, Suen KF, Arrabit C, Berton F, Kosaza T, Casey PJ, Slesinger PA. Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. Molecular and Cellular Neurosciences. 28: 375-89. PMID 15691717 DOI: 10.1016/J.Mcn.2004.10.009  0.502
2004 Panicker S, Cruz H, Arrabit C, Suen KF, Slesinger PA. Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor. The Journal of Biological Chemistry. 279: 28149-58. PMID 15131114 DOI: 10.1074/Jbc.M403545200  0.64
2004 Cruz HG, Ivanova T, Lunn ML, Stoffel M, Slesinger PA, Lüscher C. Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. Nature Neuroscience. 7: 153-9. PMID 14745451 DOI: 10.1038/Nn1181  0.477
2004 Finley M, Arrabit C, Fowler C, Suen KF, Slesinger PA. betaL-betaM loop in the C-terminal domain of G protein-activated inwardly rectifying K(+) channels is important for G(betagamma) subunit activation. The Journal of Physiology. 555: 643-57. PMID 14724209 DOI: 10.1113/Jphysiol.2003.056101  0.453
2002 Panicker S, Cruz H, Arrabit C, Slesinger PA. Evidence for a centrally located gate in the pore of a serotonin-gated ion channel. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 1629-39. PMID 11880493 DOI: 10.1523/Jneurosci.22-05-01629.2002  0.674
2001 Zhou W, Arrabit C, Choe S, Slesinger PA. Mechanism underlying bupivacaine inhibition of G protein-gated inwardly rectifying K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 98: 6482-7. PMID 11353868 DOI: 10.1073/Pnas.111447798  0.52
2001 Slesinger PA. Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels. Biophysical Journal. 80: 707-18. PMID 11159438 DOI: 10.1016/S0006-3495(01)76050-X  0.426
1997 Slesinger PA, Stoffel M, Jan YN, Jan LY. Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 94: 12210-7. PMID 9342388 DOI: 10.1073/pnas.94.22.12210  0.573
1996 Slesinger PA, Lansman JB. Reopening of single L-type Ca2+ channels in mouse cerebellar granule cells: dependence on voltage and ion concentration. The Journal of Physiology. 491: 335-45. PMID 8866858 DOI: 10.1113/Jphysiol.1996.Sp021219  0.678
1996 Slesinger PA, Patil N, Liao YJ, Jan YN, Jan LY, Cox DR. Functional effects of the mouse weaver mutation on G protein-gated inwardly rectifying K+ channels. Neuron. 16: 321-31. PMID 8789947 DOI: 10.1016/S0896-6273(00)80050-1  0.605
1995 Slesinger PA, Reuveny E, Jan YN, Jan LY. Identification of structural elements involved in G protein gating of the GIRK1 potassium channel. Neuron. 15: 1145-56. PMID 7576657 DOI: 10.1016/0896-6273(95)90102-7  0.74
1995 Huang CL, Slesinger PA, Casey PJ, Jan YN, Jan LY. Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. Neuron. 15: 1133-43. PMID 7576656 DOI: 10.1016/0896-6273(95)90101-9  0.555
1995 Kubo Y, Reuveny E, Slesinger PA, Baldwin TJ, Jan YN, Jan LY. Primary structure and functional expression of a mouse inward rectifier K+ channel and rat G-protein-coupled muscarinic K+ channel. Japanese Journal of Electrocardiology. 15: 106-113. DOI: 10.5105/Jse.15.106  0.722
1994 Reuveny E, Slesinger PA, Inglese J, Morales JM, Iñiguez-Lluhi JA, Lefkowitz RJ, Bourne HR, Jan YN, Jan LY. Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature. 370: 143-6. PMID 8022483 DOI: 10.1038/370143A0  0.737
1993 Slesinger PA, Jan YN, Jan LY. The S4-S5 loop contributes to the ion-selective pore of potassium channels. Neuron. 11: 739-49. PMID 8398157 DOI: 10.1016/0896-6273(93)90083-4  0.507
1993 Haws CM, Slesinger PA, Lansman JB. Dihydropyridine- and omega-conotoxin-sensitive Ca2+ currents in cerebellar neurons: persistent block of L-type channels by a pertussis toxin-sensitive G-protein. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 1148-56. PMID 8382734 DOI: 10.1523/Jneurosci.13-03-01148.1993  0.704
1993 Kubo Y, Reuveny E, Slesinger PA, Jan YN, Jan LY. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 364: 802-6. PMID 8355805 DOI: 10.1038/364802A0  0.747
1991 Slesinger PA, Lansman JB. Inactivation of calcium currents in granule cells cultured from mouse cerebellum. The Journal of Physiology. 435: 101-21. PMID 1663157 DOI: 10.1113/Jphysiol.1991.Sp018500  0.659
1991 Slesinger PA, Lansman JB. Reopening of Ca2+ channels in mouse cerebellar neurons at resting membrane potentials during recovery from inactivation. Neuron. 7: 755-62. PMID 1660284 DOI: 10.1016/0896-6273(91)90278-8  0.695
1991 Slesinger PA, Lansman JB. Inactivating and non-inactivating dihydropyridine-sensitive Ca2+ channels in mouse cerebellar granule cells. The Journal of Physiology. 439: 301-23. PMID 1654414 DOI: 10.1113/Jphysiol.1991.Sp018668  0.708
1991 Lansman JB, Slesinger P. Single-channel behavior underlying decaying and non-decaying components of calcium channel current in cerebellar neurons Biomedical Research. 12: 57-59.  0.718
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