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Juan Carlos Saez - Publications

Affiliations: 
Physiology P. Universidad Catolica de Chile, Santiago, Región Metropolitana, Chile 
Area:
connexin, pannexin
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161 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 García-Rodríguez C, Duarte Y, Ardiles ÁO, Sáez JC. The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes. Journal of Neurochemistry. PMID 38291613 DOI: 10.1111/jnc.16062  0.32
2024 Abudara V, Araneda RC, Barrio L, Berthoud VM, Contreras JE, Eugenín E, Lerma J, Orellana JA, Palacios-Prado N, Pérez-Armendariz M, Retamal MA, Sáez JC. Remembrances of Dr. Michael V.L. Bennett by Iberoamerican Colleagues and Friends. Neuroscience. PMID 38278514 DOI: 10.1016/j.neuroscience.2024.01.011  0.713
2023 Li H, Guo A, Salgado M, Sáez JC, Lau CG. The connexin hemichannel inhibitor D4 produces rapid antidepressant-like effects in mice. Journal of Neuroinflammation. 20: 191. PMID 37599352 DOI: 10.1186/s12974-023-02873-z  0.587
2023 Güiza J, Solís F, Valenzuela B, Arancibia D, Zamorano P, González J, Saavedra J, Neely A, Salgado M, Martínez AD, Sáez JC, Vega JL. Unnexin is a protein subunit of a large-pore channel expressed by unicellular organisms. Proceedings of the National Academy of Sciences of the United States of America. 120: e2307898120. PMID 37487087 DOI: 10.1073/pnas.2307898120  0.375
2023 Vega JL, Gutiérrez C, Rojas M, Güiza J, Sáez JC. Contribution of large-pore channels to inflammation induced by microorganisms. Frontiers in Cell and Developmental Biology. 10: 1094362. PMID 36699007 DOI: 10.3389/fcell.2022.1094362  0.303
2023 Abbott AC, García IE, Villanelo F, Flores-Muñoz C, Ceriani R, Maripillán J, Novoa-Molina J, Figueroa-Cares C, Pérez-Acle T, Sáez JC, Sánchez HA, Martínez AD. Expression of KID syndromic mutation Cx26S17F produces hyperactive hemichannels in supporting cells of the organ of Corti. Frontiers in Cell and Developmental Biology. 10: 1071202. PMID 36699003 DOI: 10.3389/fcell.2022.1071202  0.306
2022 Guo A, Zhang H, Li H, Chiu A, García-Rodríguez C, Lagos CF, Sáez JC, Lau CG. Inhibition of connexin hemichannels alleviates neuroinflammation and hyperexcitability in temporal lobe epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 119: e2213162119. PMID 36322757 DOI: 10.1073/pnas.2213162119  0.636
2022 Palacios-Prado N, Soto PA, López X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, González-Nilo FD, Sáez JC. Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties. Proceedings of the National Academy of Sciences of the United States of America. 119: e2202104119. PMID 35486697 DOI: 10.1073/pnas.2202104119  0.774
2021 López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC. A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34301850 DOI: 10.1073/pnas.2108967118  0.758
2020 López X, Escamilla R, Fernández P, Duarte Y, González-Nilo F, Palacios-Prado N, Martinez AD, Sáez JC. Stretch-Induced Activation of Pannexin 1 Channels Can Be Prevented by PKA-Dependent Phosphorylation. International Journal of Molecular Sciences. 21. PMID 33276429 DOI: 10.3390/ijms21239180  0.745
2020 Choi EJ, Palacios-Prado N, Sáez JC, Lee J. Identification of Cx45 as a Major Component of GJs in HeLa Cells. Biomolecules. 10. PMID 33003547 DOI: 10.3390/biom10101389  0.758
2020 Recabal A, Fernández P, López S, Barahona MJ, Ordenes P, Alejandra P, Elizondo-Vega R, Farkas C, Uribe A, Caprile T, Sáez JC, García-Robles MA. The FGF2-induced tanycyte proliferation involves a connexin 43 hemichannel/purinergic-dependent pathway. Journal of Neurochemistry. PMID 32936929 DOI: 10.1111/Jnc.15188  0.429
2020 Cea LA, Fernández G, Arias-Bravo G, Castillo-Ruiz M, Escamilla R, Brañes MC, Sáez JC. Blockade of Hemichannels Normalizes the Differentiation Fate of Myoblasts and Features of Skeletal Muscles from Dysferlin-Deficient Mice. International Journal of Molecular Sciences. 21. PMID 32825681 DOI: 10.3390/Ijms21176025  0.363
2020 Balboa E, Saavedra F, Cea LA, Ramírez V, Escamilla R, Vargas AA, Regueira T, Sáez JC. Vitamin E Blocks Connexin Hemichannels and Prevents Deleterious Effects of Glucocorticoid Treatment on Skeletal Muscles. International Journal of Molecular Sciences. 21. PMID 32521774 DOI: 10.3390/Ijms21114094  0.344
2020 Giaume CB, Naus CC, Saez JC, Leybaert L. Glial connexins and pannexins in the healthy and diseased brain. Physiological Reviews. PMID 32326824 DOI: 10.1152/Physrev.00043.2018  0.423
2020 Fernández G, Arias GB, Bevilacqua JA, Castillo-Ruiz M, Caviedes P, Sáez JC, Cea LA. Myofibers deficient in connexins 43 and 45 expression protect mice from skeletal muscle and systemic dysfunction promoted by a dysferlin mutation. Biochimica Et Biophysica Acta. Molecular Basis of Disease. 165800. PMID 32305450 DOI: 10.1016/J.Bbadis.2020.165800  0.346
2020 Pareja-Barrueto C, Rojas M, Sáez JC, Gonzalez-Nilo D. Molecular Determinants of Gap Junction Channels Conductance Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.1688  0.385
2019 Li T, Niu J, Yu G, Ezan P, Yi C, Wang X, Koulakoff A, Gao X, Chen X, Sáez JC, Giaume C, Xiao L. Connexin 43 deletion in astrocytes promotes CNS remyelination by modulating local inflammation. Glia. PMID 31868275 DOI: 10.1002/Glia.23770  0.364
2019 Asencio-Barría C, Defamie N, Sáez JC, Mesnil M, Godoy AS. Direct Intercellular Communications and Cancer: A Snapshot of the Biological Roles of Connexins in Prostate Cancer. Cancers. 11. PMID 31540089 DOI: 10.3390/Cancers11091370  0.322
2018 Wellmann M, Álvarez-Ferradas C, Maturana CJ, Sáez JC, Bonansco C. Astroglial Ca-Dependent Hyperexcitability Requires P2Y Purinergic Receptors and Pannexin-1 Channel Activation in a Chronic Model of Epilepsy. Frontiers in Cellular Neuroscience. 12: 446. PMID 30542266 DOI: 10.3389/Fncel.2018.00446  0.364
2018 Güiza J, Barría I, Sáez JC, Vega JL. Innexins: Expression, Regulation, and Functions. Frontiers in Physiology. 9: 1414. PMID 30364195 DOI: 10.3389/Fphys.2018.01414  0.397
2018 Sáez PJ, Sáez JC, Lennon-Duménil AM, Vargas P. Role of calcium permeable channels in dendritic cell migration. Current Opinion in Immunology. 52: 74-80. PMID 29715579 DOI: 10.1016/J.Coi.2018.04.005  0.365
2018 Gómez GI, Fernández P, Velarde V, Sáez JC. Angiotensin II-Induced Mesangial Cell Damaged Is Preceded by Cell Membrane Permeabilization Due to Upregulation of Non-Selective Channels. International Journal of Molecular Sciences. 19. PMID 29570626 DOI: 10.3390/Ijms19040957  0.47
2017 Barría I, Güiza J, Cifuentes F, Zamorano P, Sáez JC, González J, Vega JL. Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. The American Journal of Tropical Medicine and Hygiene. PMID 29141748 DOI: 10.4269/Ajtmh.17-0293  0.361
2017 Giaume C, Sáez JC, Song W, Leybaert L, Naus CC. Connexins and Pannexins in Alzheimer's Disease. Neuroscience Letters. PMID 28893592 DOI: 10.1016/J.Neulet.2017.09.006  0.374
2017 Rovegno M, Sáez JC. Role of astrocyte connexin hemichannels in cortical spreading depression. Biochimica Et Biophysica Acta. PMID 28864364 DOI: 10.1016/J.Bbamem.2017.08.014  0.396
2017 Yi C, Ezan P, Fernández P, Schmitt J, Sáez JC, Giaume C, Koulakoff A. Inhibition of glial hemichannels by boldine treatment reduces neuronal suffering in a murine model of Alzheimer's disease. Glia. PMID 28703353 DOI: 10.1002/Glia.23182  0.342
2017 Charvériat M, Naus CC, Leybaert L, Sáez JC, Giaume C. Connexin-Dependent Neuroglial Networking as a New Therapeutic Target. Frontiers in Cellular Neuroscience. 11: 174. PMID 28694772 DOI: 10.3389/Fncel.2017.00174  0.338
2017 Balboa E, Saavedra F, Cea LA, Vargas AA, Ramírez V, Escamilla R, Sáez JC, Regueira T. Sepsis-Induced Channelopathy in Skeletal Muscles is Associated with Expression of Non-Selective Channels. Shock (Augusta, Ga.). PMID 28562477 DOI: 10.1097/Shk.0000000000000916  0.39
2017 Vargas AA, Cisterna BA, Saavedra-Leiva F, Urrutia C, Cea LA, Vielma AH, Gutierrez-Maldonado SE, Martin AJ, Pareja-Barrueto C, Escalona Y, Schmachtenberg O, Lagos CF, Perez-Acle T, Sáez JC. On Biophysical Properties and Sensitivity to Gap Junction Blockers of Connexin 39 Hemichannels Expressed in HeLa Cells. Frontiers in Physiology. 8: 38. PMID 28232803 DOI: 10.3389/Fphys.2017.00038  0.524
2017 Sáez JC. Unraveling a novel mechanism for the up-regulation of connexin43 gap junctions between cells derived from the blood-brain barrier. The Journal of Physiology. PMID 28205211 DOI: 10.1113/Jp274027  0.441
2017 Puebla C, Retamal MA, Acuña R, Sáez JC. Regulation of Connexin-Based Channels by Fatty Acids. Frontiers in Physiology. 8: 11. PMID 28174541 DOI: 10.3389/Fphys.2017.00011  0.462
2016 Gajardo-Gómez R, Labra VC, Maturana CJ, Shoji KF, Santibañez CA, Sáez JC, Giaume C, Orellana JA. Cannabinoids prevent the amyloid β-induced activation of astroglial hemichannels: A neuroprotective mechanism. Glia. PMID 27757991 DOI: 10.1002/Glia.23080  0.355
2016 Johnson RG, Le HC, Evenson K, Loberg SW, Myslajek TM, Prabhu A, Manley AM, O'Shea C, Grunenwald H, Haddican M, Fitzgerald PM, Robinson T, Cisterna BA, Sáez JC, Liu TF, et al. Connexin Hemichannels: Methods for Dye Uptake and Leakage. The Journal of Membrane Biology. PMID 27586664 DOI: 10.1007/S00232-016-9925-Y  0.465
2016 Cisterna BA, Vargas AA, Puebla C, Sáez JC. Connexin hemichannels explain the ionic imbalance and lead to atrophy in denervated skeletal muscles. Biochimica Et Biophysica Acta. PMID 27580092 DOI: 10.1016/J.Bbadis.2016.08.020  0.316
2016 Cea LA, Balboa E, Puebla C, Vargas AA, Cisterna BA, Escamilla R, Regueira T, Sáez JC. Dexamethasone-induced muscular atrophy is mediated by functional expression of connexin-based hemichannels. Biochimica Et Biophysica Acta. PMID 27437607 DOI: 10.1016/J.Bbadis.2016.07.003  0.425
2016 Sáez JC. Proceedings of the International Gap Junction Conference 2015. Bmc Cell Biology. 17: 18. PMID 27229860 DOI: 10.1186/S12860-016-0097-5  0.418
2016 Cea LA, Bevilacqua JA, Arriagada C, Cárdenas AM, Bigot A, Mouly V, Sáez JC, Caviedes P. The absence of dysferlin induces the expression of functional connexin-based hemichannels in human myotubes. Bmc Cell Biology. 17: 15. PMID 27229680 DOI: 10.1186/S12860-016-0096-6  0.347
2016 Puebla C, Cisterna BA, Salas DP, Delgado-López F, Lampe PD, Sáez JC. Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism. Biochimica Et Biophysica Acta. PMID 26869446 DOI: 10.1016/J.Bbalip.2016.02.002  0.444
2015 Talaverón R, Fernández P, Escamilla R, Pastor AM, Matarredona ER, Sáez JC. Neural progenitor cells isolated from the subventricular zone present hemichannel activity and form functional gap junctions with glial cells. Frontiers in Cellular Neuroscience. 9: 411. PMID 26528139 DOI: 10.3389/Fncel.2015.00411  0.481
2015 Sáez JC, Cisterna BA, Vargas A, Cardozo CP. Regulation of pannexin and connexin channels and their functional role in skeletal muscles. Cellular and Molecular Life Sciences : Cmls. 72: 2929-35. PMID 26084874 DOI: 10.1007/S00018-015-1968-1  0.448
2015 Riquelme MA, Cea LA, Vega JL, Puebla C, Vargas AA, Shoji KF, Subiabre M, Sáez JC. Pannexin channels mediate the acquisition of myogenic commitment in C2C12 reserve cells promoted by P2 receptor activation. Frontiers in Cell and Developmental Biology. 3: 25. PMID 26000275 DOI: 10.3389/Fcell.2015.00025  0.411
2015 Salas D, Puebla C, Lampe PD, Lavandero S, Sáez JC. Role of Akt and Ca(2+) on cell permeabilization via connexin43 hemichannels induced by metabolic inhibition. Biochimica Et Biophysica Acta. 1852: 1268-77. PMID 25779082 DOI: 10.1016/J.Bbadis.2015.03.004  0.411
2015 Rovegno M, Soto PA, Sáez PJ, Naus CC, Sáez JC, von Bernhardi R. Connexin43 hemichannels mediate secondary cellular damage spread from the trauma zone to distal zones in astrocyte monolayers. Glia. 63: 1185-99. PMID 25731866 DOI: 10.1002/Glia.22808  0.416
2015 García IE, Maripillán J, Jara O, Ceriani R, Palacios-Muñoz A, Ramachandran J, Olivero P, Perez-Acle T, González C, Sáez JC, Contreras JE, Martínez AD. Keratitis-ichthyosis-deafness syndrome-associated Cx26 mutants produce nonfunctional gap junctions but hyperactive hemichannels when co-expressed with wild type Cx43. The Journal of Investigative Dermatology. 135: 1338-47. PMID 25625422 DOI: 10.1038/Jid.2015.20  0.69
2014 Cisterna BA, Cardozo C, Sáez JC. Neuronal involvement in muscular atrophy. Frontiers in Cellular Neuroscience. 8: 405. PMID 25540609 DOI: 10.3389/Fncel.2014.00405  0.366
2014 Retamal MA, Sáez JC. Hemichannels; from the molecule to the function. Frontiers in Physiology. 5: 411. PMID 25368583 DOI: 10.3389/Fphys.2014.00411  0.497
2014 Ardiles AO, Flores-Muñoz C, Toro-Ayala G, Cárdenas AM, Palacios AG, Muñoz P, Fuenzalida M, Sáez JC, Martínez AD. Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice. Frontiers in Cellular Neuroscience. 8: 326. PMID 25360084 DOI: 10.3389/Fncel.2014.00326  0.335
2014 Sáez PJ, Shoji KF, Aguirre A, Sáez JC. Regulation of hemichannels and gap junction channels by cytokines in antigen-presenting cells. Mediators of Inflammation. 2014: 742734. PMID 25301274 DOI: 10.1155/2014/742734  0.442
2014 Momboisse F, Olivares MJ, Báez-Matus X, Guerra MJ, Flores-Muñoz C, Sáez JC, Martínez AD, Cárdenas AM. Pannexin 1 channels: new actors in the regulation of catecholamine release from adrenal chromaffin cells. Frontiers in Cellular Neuroscience. 8: 270. PMID 25237296 DOI: 10.3389/Fncel.2014.00270  0.423
2014 Figueroa VA, Retamal MA, Cea LA, Salas JD, Vargas AA, Verdugo CA, Jara O, Martínez AD, Sáez JC. Extracellular gentamicin reduces the activity of connexin hemichannels and interferes with purinergic Ca(2+) signaling in HeLa cells. Frontiers in Cellular Neuroscience. 8: 265. PMID 25237294 DOI: 10.3389/Fncel.2014.00265  0.478
2014 Araya-Secchi R, Perez-Acle T, Kang SG, Huynh T, Bernardin A, Escalona Y, Garate JA, Martínez AD, García IE, Sáez JC, Zhou R. Characterization of a novel water pocket inside the human Cx26 hemichannel structure. Biophysical Journal. 107: 599-612. PMID 25099799 DOI: 10.1016/J.Bpj.2014.05.037  0.31
2014 Retamal MA, Alcayaga J, Verdugo CA, Bultynck G, Leybaert L, Sáez PJ, Fernández R, León LE, Sáez JC. Opening of pannexin- and connexin-based channels increases the excitability of nodose ganglion sensory neurons. Frontiers in Cellular Neuroscience. 8: 158. PMID 24999316 DOI: 10.3389/Fncel.2014.00158  0.409
2014 Cea LA, Riquelme MA, Vargas AA, Urrutia C, Sáez JC. Pannexin 1 channels in skeletal muscles. Frontiers in Physiology. 5: 139. PMID 24782784 DOI: 10.3389/Fphys.2014.00139  0.411
2014 Sáez JC, Leybaert L. Hunting for connexin hemichannels. Febs Letters. 588: 1205-11. PMID 24631534 DOI: 10.1016/J.Febslet.2014.03.004  0.424
2014 Shoji KF, Sáez PJ, Harcha PA, Aguila HL, Sáez JC. Pannexin1 channels act downstream of P2X 7 receptors in ATP-induced murine T-cell death. Channels (Austin, Tex.). 8: 142-56. PMID 24590064 DOI: 10.4161/Chan.28122  0.434
2014 Le HT, Sin WC, Lozinsky S, Bechberger J, Vega JL, Guo XQ, Sáez JC, Naus CC. Gap junction intercellular communication mediated by connexin43 in astrocytes is essential for their resistance to oxidative stress. The Journal of Biological Chemistry. 289: 1345-54. PMID 24302722 DOI: 10.1074/Jbc.M113.508390  0.454
2014 Orellana JA, Sáez JC, Bennett MV, Berman JW, Morgello S, Eugenin EA. HIV increases the release of dickkopf-1 protein from human astrocytes by a Cx43 hemichannel-dependent mechanism. Journal of Neurochemistry. 128: 752-63. PMID 24134157 DOI: 10.1111/Jnc.12492  0.464
2013 Hernández-Salinas R, Vielma AZ, Arismendi MN, Boric MP, Sáez JC, Velarde V. Boldine prevents renal alterations in diabetic rats. Journal of Diabetes Research. 2013: 593672. PMID 24416726 DOI: 10.1155/2013/593672  0.334
2013 Vega JL, Subiabre M, Figueroa F, Schalper KA, Osorio L, González J, Sáez JC. Role of gap junctions and hemichannels in parasitic infections. Biomed Research International. 2013: 589130. PMID 24236292 DOI: 10.1155/2013/589130  0.427
2013 Cea LA, Cisterna BA, Puebla C, Frank M, Figueroa XF, Cardozo C, Willecke K, Latorre R, Sáez JC. De novo expression of connexin hemichannels in denervated fast skeletal muscles leads to atrophy. Proceedings of the National Academy of Sciences of the United States of America. 110: 16229-34. PMID 24043768 DOI: 10.1073/Pnas.1312331110  0.414
2013 Sáez PJ, Orellana JA, Vega-Riveros N, Figueroa VA, Hernández DE, Castro JF, Klein AD, Jiang JX, Zanlungo S, Sáez JC. Disruption in connexin-based communication is associated with intracellular Ca²⁺ signal alterations in astrocytes from Niemann-Pick type C mice. Plos One. 8: e71361. PMID 23977027 DOI: 10.1371/Journal.Pone.0071361  0.448
2013 Aguirre A, Maturana CJ, Harcha PA, Sáez JC. Possible involvement of TLRs and hemichannels in stress-induced CNS dysfunction via mastocytes, and glia activation. Mediators of Inflammation. 2013: 893521. PMID 23935250 DOI: 10.1155/2013/893521  0.416
2013 Giaume C, Leybaert L, Naus CC, Sáez JC. Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles. Frontiers in Pharmacology. 4: 88. PMID 23882216 DOI: 10.3389/Fphar.2013.00088  0.395
2013 Sáez PJ, Shoji KF, Retamal MA, Harcha PA, Ramírez G, Jiang JX, von Bernhardi R, Sáez JC. ATP is required and advances cytokine-induced gap junction formation in microglia in vitro. Mediators of Inflammation. 2013: 216402. PMID 23737642 DOI: 10.1155/2013/216402  0.411
2013 Kozoriz MG, Lai S, Vega JL, Sáez JC, Sin WC, Bechberger JF, Naus CC. Cerebral ischemic injury is enhanced in a model of oculodentodigital dysplasia. Neuropharmacology. 75: 549-56. PMID 23727526 DOI: 10.1016/J.Neuropharm.2013.05.003  0.354
2013 Riquelme MA, Cea LA, Vega JL, Boric MP, Monyer H, Bennett MV, Frank M, Willecke K, Sáez JC. The ATP required for potentiation of skeletal muscle contraction is released via pannexin hemichannels. Neuropharmacology. 75: 594-603. PMID 23583931 DOI: 10.1016/J.Neuropharm.2013.03.022  0.512
2013 Figueroa XF, Lillo MA, Gaete PS, Riquelme MA, Sáez JC. Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels. Neuropharmacology. 75: 471-8. PMID 23499665 DOI: 10.1016/J.Neuropharm.2013.02.022  0.502
2013 Figueroa V, Sáez PJ, Salas JD, Salas D, Jara O, Martínez AD, Sáez JC, Retamal MA. Linoleic acid induces opening of connexin26 hemichannels through a PI3K/Akt/Ca(2+)-dependent pathway. Biochimica Et Biophysica Acta. 1828: 1169-79. PMID 23261389 DOI: 10.1016/J.Bbamem.2012.12.006  0.417
2013 Aguirre A, Shoji KF, Sáez JC, Henríquez M, Quest AF. FasL-triggered death of Jurkat cells requires caspase 8-induced, ATP-dependent cross-talk between Fas and the purinergic receptor P2X(7). Journal of Cellular Physiology. 228: 485-93. PMID 22806078 DOI: 10.1002/Jcp.24159  0.348
2012 Bennett MV, Garré JM, Orellana JA, Bukauskas FF, Nedergaard M, Sáez JC. Connexin and pannexin hemichannels in inflammatory responses of glia and neurons. Brain Research. 1487: 3-15. PMID 22975435 DOI: 10.1016/J.Brainres.2012.08.042  0.575
2012 Cea LA, Riquelme MA, Cisterna BA, Puebla C, Vega JL, Rovegno M, Sáez JC. Connexin- and pannexin-based channels in normal skeletal muscles and their possible role in muscle atrophy. The Journal of Membrane Biology. 245: 423-36. PMID 22850938 DOI: 10.1007/S00232-012-9485-8  0.419
2012 Jara O, Acuña R, García IE, Maripillán J, Figueroa V, Sáez JC, Araya-Secchi R, Lagos CF, Pérez-Acle T, Berthoud VM, Beyer EC, Martínez AD. Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function. Molecular Biology of the Cell. 23: 3299-311. PMID 22787277 DOI: 10.1091/Mbc.E11-12-1058  0.395
2012 Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA. Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3649-57. PMID 22665389 DOI: 10.1096/Fj.11-198416  0.319
2012 Pérez-Armendariz EM, Cruz-Miguel L, Coronel-Cruz C, Esparza-Aguilar M, Pinzon-Estrada E, Rancaño-Camacho E, Zacarias-Climaco G, Olivares PF, Espinosa AM, Becker I, Sáez JC, Berumen J, Pérez-Palacios G. Connexin 36 is expressed in beta and connexins 26 and 32 in acinar cells at the end of the secondary transition of mouse pancreatic development and increase during fetal and perinatal life. Anatomical Record (Hoboken, N.J. : 2007). 295: 980-90. PMID 22505190 DOI: 10.1002/Ar.22473  0.374
2012 Orellana JA, von Bernhardi R, Giaume C, Sáez JC. Glial hemichannels and their involvement in aging and neurodegenerative diseases. Reviews in the Neurosciences. 23: 163-77. PMID 22499675 DOI: 10.1515/Revneuro-2011-0065  0.44
2012 Orellana JA, Sánchez HA, Schalper KA, Figueroa V, Sáez JC. Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Advances in Experimental Medicine and Biology. 740: 777-94. PMID 22453969 DOI: 10.1007/978-94-007-2888-2_34  0.435
2012 Eugenin EA, Basilio D, Sáez JC, Orellana JA, Raine CS, Bukauskas F, Bennett MV, Berman JW. The role of gap junction channels during physiologic and pathologic conditions of the human central nervous system. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 7: 499-518. PMID 22438035 DOI: 10.1007/S11481-012-9352-5  0.616
2012 Schalper KA, Riquelme MA, Brañes MC, Martínez AD, Vega JL, Berthoud VM, Bennett MV, Sáez JC. Modulation of gap junction channels and hemichannels by growth factors. Molecular Biosystems. 8: 685-98. PMID 22218428 DOI: 10.1039/C1Mb05294B  0.611
2012 Giaume C, Orellana JA, Abudara V, Sáez JC. Connexin-based channels in astrocytes: how to study their properties. Methods in Molecular Biology (Clifton, N.J.). 814: 283-303. PMID 22144314 DOI: 10.1007/978-1-61779-452-0_19  0.461
2012 Koulakoff A, Mei X, Orellana JA, Sáez JC, Giaume C. Glial connexin expression and function in the context of Alzheimer's disease. Biochimica Et Biophysica Acta. 1818: 2048-57. PMID 22008509 DOI: 10.1016/J.Bbamem.2011.10.001  0.404
2012 Orellana JA, Sáez PJ, Cortés-Campos C, Elizondo RJ, Shoji KF, Contreras-Duarte S, Figueroa V, Velarde V, Jiang JX, Nualart F, Sáez JC, García MA. Glucose increases intracellular free Ca(2+) in tanycytes via ATP released through connexin 43 hemichannels. Glia. 60: 53-68. PMID 21987367 DOI: 10.1002/Glia.21246  0.368
2011 Orellana JA, Díaz E, Schalper KA, Vargas AA, Bennett MV, Sáez JC. Cation permeation through connexin 43 hemichannels is cooperative, competitive and saturable with parameters depending on the permeant species. Biochemical and Biophysical Research Communications. 409: 603-9. PMID 21600880 DOI: 10.1016/J.Bbrc.2011.05.031  0.543
2011 Orellana JA, Shoji KF, Abudara V, Ezan P, Amigou E, Sáez PJ, Jiang JX, Naus CC, Sáez JC, Giaume C. Amyloid β-induced death in neurons involves glial and neuronal hemichannels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4962-77. PMID 21451035 DOI: 10.1523/Jneurosci.6417-10.2011  0.371
2011 Orellana JA, Froger N, Ezan P, Jiang JX, Bennett MV, Naus CC, Giaume C, Sáez JC. ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels. Journal of Neurochemistry. 118: 826-40. PMID 21294731 DOI: 10.1111/J.1471-4159.2011.07210.X  0.522
2011 Orellana JA, Figueroa XF, Sánchez HA, Contreras-Duarte S, Velarde V, Sáez JC. Hemichannels in the neurovascular unit and white matter under normal and inflamed conditions. Cns & Neurological Disorders Drug Targets. 10: 404-14. PMID 21288190 DOI: 10.2174/187152711794653869  0.492
2010 Garré JM, Retamal MA, Cassina P, Barbeito L, Bukauskas FF, Sáez JC, Bennett MV, Abudara V. FGF-1 induces ATP release from spinal astrocytes in culture and opens pannexin and connexin hemichannels. Proceedings of the National Academy of Sciences of the United States of America. 107: 22659-64. PMID 21148774 DOI: 10.1073/Pnas.1013793107  0.564
2010 Schalper KA, Sánchez HA, Lee SC, Altenberg GA, Nathanson MH, Sáez JC. Connexin 43 hemichannels mediate the Ca2+ influx induced by extracellular alkalinization. American Journal of Physiology. Cell Physiology. 299: C1504-15. PMID 20881238 DOI: 10.1152/Ajpcell.00015.2010  0.377
2010 Froger N, Orellana JA, Calvo CF, Amigou E, Kozoriz MG, Naus CC, Sáez JC, Giaume C. Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Molecular and Cellular Neurosciences. 45: 37-46. PMID 20684043 DOI: 10.1016/J.Mcn.2010.05.007  0.414
2010 Sáez JC, Schalper KA, Retamal MA, Orellana JA, Shoji KF, Bennett MV. Cell membrane permeabilization via connexin hemichannels in living and dying cells. Experimental Cell Research. 316: 2377-89. PMID 20595004 DOI: 10.1016/J.Yexcr.2010.05.026  0.626
2010 Orellana JA, Hernández DE, Ezan P, Velarde V, Bennett MV, Giaume C, Sáez JC. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia. 58: 329-43. PMID 19705457 DOI: 10.1002/Glia.20926  0.567
2009 Froger N, Orellana JA, Cohen-Salmon M, Ezan P, Amigou E, Sáez JC, Giaume C. Cannabinoids prevent the opposite regulation of astroglial connexin43 hemichannels and gap junction channels induced by pro-inflammatory treatments. Journal of Neurochemistry. 111: 1383-97. PMID 20050288 DOI: 10.1111/J.1471-4159.2009.06407.X  0.397
2009 Buvinic S, Almarza G, Bustamante M, Casas M, López J, Riquelme M, Sáez JC, Huidobro-Toro JP, Jaimovich E. ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle. The Journal of Biological Chemistry. 284: 34490-505. PMID 19822518 DOI: 10.1074/Jbc.M109.057315  0.339
2009 Sánchez HA, Orellana JA, Verselis VK, Sáez JC. Metabolic inhibition increases activity of connexin-32 hemichannels permeable to Ca2+ in transfected HeLa cells. American Journal of Physiology. Cell Physiology. 297: C665-78. PMID 19587218 DOI: 10.1152/Ajpcell.00200.2009  0.729
2009 Elgueta R, Tobar JA, Shoji KF, De Calisto J, Kalergis AM, Bono MR, Rosemblatt M, Sáez JC. Gap junctions at the dendritic cell-T cell interface are key elements for antigen-dependent T cell activation. Journal of Immunology (Baltimore, Md. : 1950). 183: 277-84. PMID 19542439 DOI: 10.4049/Jimmunol.0801854  0.34
2009 Schalper KA, Orellana JA, Berthoud VM, Sáez JC. Dysfunctions of the diffusional membrane pathways mediated by hemichannels in inherited and acquired human diseases. Current Vascular Pharmacology. 7: 486-505. PMID 19485891 DOI: 10.2174/157016109789043937  0.421
2009 Orellana JA, Sáez PJ, Shoji KF, Schalper KA, Palacios-Prado N, Velarde V, Giaume C, Bennett MV, Sáez JC. Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxidants & Redox Signaling. 11: 369-99. PMID 18816186 DOI: 10.1089/Ars.2008.2130  0.809
2008 Schalper KA, Palacios-Prado N, Orellana JA, Sáez JC. Currently used methods for identification and characterization of hemichannels. Cell Communication & Adhesion. 15: 207-18. PMID 18649191 DOI: 10.1080/15419060802014198  0.749
2008 Schalper KA, Palacios-Prado N, Retamal MA, Shoji KF, Martínez AD, Sáez JC. Connexin hemichannel composition determines the FGF-1-induced membrane permeability and free [Ca2+]i responses. Molecular Biology of the Cell. 19: 3501-13. PMID 18495870 DOI: 10.1091/Mbc.E07-12-1240  0.764
2008 Sáez JC. Astrocytes as connexin-dependent signaling cells for local blood flow regulation. American Journal of Physiology. Heart and Circulatory Physiology. 294: H586-7. PMID 18178716 DOI: 10.1152/Ajpheart.91445.2007  0.37
2007 Retamal MA, Froger N, Palacios-Prado N, Ezan P, Sáez PJ, Sáez JC, Giaume C. Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13781-92. PMID 18077690 DOI: 10.1523/Jneurosci.2042-07.2007  0.781
2007 Eugenín EA, González HE, Sánchez HA, Brañes MC, Sáez JC. Inflammatory conditions induce gap junctional communication between rat Kupffer cells both in vivo and in vitro. Cellular Immunology. 247: 103-10. PMID 17900549 DOI: 10.1016/J.Cellimm.2007.08.001  0.454
2007 Retamal MA, Schalper KA, Shoji KF, Orellana JA, Bennett MV, Sáez JC. Possible involvement of different connexin43 domains in plasma membrane permeabilization induced by ischemia-reperfusion. The Journal of Membrane Biology. 218: 49-63. PMID 17705051 DOI: 10.1007/S00232-007-9043-Y  0.597
2007 Retamal MA, Schalper KA, Shoji KF, Bennett MV, Sáez JC. Opening of connexin 43 hemichannels is increased by lowering intracellular redox potential. Proceedings of the National Academy of Sciences of the United States of America. 104: 8322-7. PMID 17494739 DOI: 10.1073/Pnas.0702456104  0.621
2007 Corvalán LA, Araya R, Brañes MC, Sáez PJ, Kalergis AM, Tobar JA, Theis M, Willecke K, Sáez JC. Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells. Journal of Cellular Physiology. 211: 649-60. PMID 17226782 DOI: 10.1002/Jcp.20971  0.392
2006 Retamal MA, Cortés CJ, Reuss L, Bennett MV, Sáez JC. S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proceedings of the National Academy of Sciences of the United States of America. 103: 4475-80. PMID 16537412 DOI: 10.1073/Pnas.0511118103  0.563
2006 Orellana JA, Palacios-Prado N, Sáez JC. Chlorpromazine reduces the intercellular communication via gap junctions in mammalian cells. Toxicology and Applied Pharmacology. 213: 187-97. PMID 16352326 DOI: 10.1016/J.Taap.2005.10.011  0.796
2005 Sáez JC, Retamal MA, Basilio D, Bukauskas FF, Bennett MV. Connexin-based gap junction hemichannels: gating mechanisms. Biochimica Et Biophysica Acta. 1711: 215-24. PMID 15955306 DOI: 10.1016/J.Bbamem.2005.01.014  0.649
2005 Araya R, Eckardt D, Maxeiner S, Krüger O, Theis M, Willecke K, Sáez JC. Expression of connexins during differentiation and regeneration of skeletal muscle: functional relevance of connexin43. Journal of Cell Science. 118: 27-37. PMID 15601660 DOI: 10.1242/Jcs.01553  0.338
2004 Contreras JE, Sánchez HA, Véliz LP, Bukauskas FF, Bennett MV, Sáez JC. Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Research. Brain Research Reviews. 47: 290-303. PMID 15572178 DOI: 10.1016/J.Brainresrev.2004.08.002  0.785
2004 Araya R, Riquelme MA, Brandan E, Sáez JC. The formation of skeletal muscle myotubes requires functional membrane receptors activated by extracellular ATP. Brain Research. Brain Research Reviews. 47: 174-88. PMID 15572171 DOI: 10.1016/J.Brainresrev.2004.06.003  0.399
2004 Figueroa XF, Alviña K, Martínez AD, Garcés G, Rosemblatt M, Boric MP, Sáez JC. Histamine reduces gap junctional communication of human tonsil high endothelial cells in culture. Microvascular Research. 68: 247-57. PMID 15501244 DOI: 10.1016/J.Mvr.2004.06.009  0.421
2003 Araya R, Eckardt D, Riquelme MA, Willecke K, Sáez JC. Presence and importance of connexin43 during myogenesis. Cell Communication & Adhesion. 10: 451-6. PMID 14681056 DOI: 10.1080/Cac.10.4-6.451.456  0.414
2003 Contreras JE, Sáez JC, Bukauskas FF, Bennett MV. Functioning of cx43 hemichannels demonstrated by single channel properties. Cell Communication & Adhesion. 10: 245-9. PMID 14681024 DOI: 10.1080/Cac.10.4-6.245.249  0.783
2003 Bennett MV, Contreras JE, Bukauskas FF, Sáez JC. New roles for astrocytes: gap junction hemichannels have something to communicate. Trends in Neurosciences. 26: 610-7. PMID 14585601 DOI: 10.1016/J.Tins.2003.09.008  0.794
2003 Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC. Plasma membrane channels formed by connexins: their regulation and functions. Physiological Reviews. 83: 1359-400. PMID 14506308 DOI: 10.1152/Physrev.00007.2003  0.345
2003 Contreras JE, Sáez JC, Bukauskas FF, Bennett MV. Gating and regulation of connexin 43 (Cx43) hemichannels. Proceedings of the National Academy of Sciences of the United States of America. 100: 11388-93. PMID 13130072 DOI: 10.1073/Pnas.1434298100  0.779
2003 Sáez JC, Contreras JE, Bukauskas FF, Retamal MA, Bennett MV. Gap junction hemichannels in astrocytes of the CNS. Acta Physiologica Scandinavica. 179: 9-22. PMID 12940934 DOI: 10.1046/J.1365-201X.2003.01196.X  0.783
2003 Eugenín EA, Brañes MC, Berman JW, Sáez JC. TNF-alpha plus IFN-gamma induce connexin43 expression and formation of gap junctions between human monocytes/macrophages that enhance physiological responses. Journal of Immunology (Baltimore, Md. : 1950). 170: 1320-8. PMID 12538692 DOI: 10.4049/Jimmunol.170.3.1320  0.382
2002 Branes MC, Contreras JE, Sáez JC. Activation of human polymorphonuclear cells induces formation of functional gap junctions and expression of connexins. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. 8: BR313-23. PMID 12165735  0.69
2002 Martínez AD, Eugenín EA, Brañes MC, Bennett MV, Sáez JC. Identification of second messengers that induce expression of functional gap junctions in microglia cultured from newborn rats. Brain Research. 943: 191-201. PMID 12101041 DOI: 10.1016/S0006-8993(02)02621-5  0.549
2002 González HE, Eugenín EA, Garcés G, Solís N, Pizarro M, Accatino L, Sáez JC. Regulation of hepatic connexins in cholestasis: possible involvement of Kupffer cells and inflammatory mediators. American Journal of Physiology. Gastrointestinal and Liver Physiology. 282: G991-G1001. PMID 12016124 DOI: 10.1152/Ajpgi.00298.2001  0.35
2002 Contreras JE, Sánchez HA, Eugenin EA, Speidel D, Theis M, Willecke K, Bukauskas FF, Bennett MV, Sáez JC. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proceedings of the National Academy of Sciences of the United States of America. 99: 495-500. PMID 11756680 DOI: 10.1073/Pnas.012589799  0.777
2001 Eugenín EA, Eckardt D, Theis M, Willecke K, Bennett MV, Saez JC. Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-gamma and tumor necrosis factor-alpha. Proceedings of the National Academy of Sciences of the United States of America. 98: 4190-5. PMID 11259646 DOI: 10.1073/Pnas.051634298  0.531
2000 Abudara V, Eyzaguirre C, Sáez JC. Short- and long-term regulation of rat carotid body gap junctions by cAMP. Identification of connexin43, a gap junction subunit. Advances in Experimental Medicine and Biology. 475: 359-69. PMID 10849675 DOI: 10.1007/0-306-46825-5_33  0.413
2000 Sáez JC, Brañes MC, Corvalán LA, Eugenín EA, González H, Martínez AD, Palisson F. Gap junctions in cells of the immune system: structure, regulation and possible functional roles. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Mã©Dicas E Biolã³Gicas / Sociedade Brasileira De Biofã­Sica ... [Et Al.]. 33: 447-55. PMID 10775310 DOI: 10.1590/S0100-879X2000000400011  0.455
2000 Berthoud VM, Hall DH, Strahsburger E, Beyer EC, Sáez JC. Gap junctions in the chicken pineal gland. Brain Research. 861: 257-70. PMID 10760487 DOI: 10.1016/S0006-8993(00)01987-9  0.45
2000 Martínez AD, Sáez JC. Regulation of astrocyte gap junctions by hypoxia-reoxygenation. Brain Research. Brain Research Reviews. 32: 250-8. PMID 10751675 DOI: 10.1016/S0165-0173(99)00086-7  0.447
2000 Hertzberg EL, Sáez JC, Corpina RA, Roy C, Kessler JA. Use of antibodies in the analysis of connexin 43 turnover and phosphorylation. Methods (San Diego, Calif.). 20: 129-39. PMID 10671307 DOI: 10.1006/Meth.1999.0931  0.339
2000 Laird DW, Saez JC. Post-transcri ptional events in the expression of gap junctions Advances in Molecular and Cell Biology. 30: 99-128. DOI: 10.1016/S1569-2558(00)30004-2  0.39
1999 Abudara V, Garcés G, Sáez JC. Cells of the carotid body express connexin43 which is up-regulated by cAMP. Brain Research. 849: 25-33. PMID 10592284 DOI: 10.1016/S0006-8993(99)01946-0  0.428
1999 González CA, Garcés G, Sáez JC, Schöbitz K, Rodríguez EM. The ependymocytes of the bovine subcommissural organ are functionally coupled through gap junctions. Neuroscience Letters. 262: 175-8. PMID 10218884 DOI: 10.1016/S0304-3940(99)00077-4  0.322
1999 Martínez AD, Sáez JC. Arachidonic acid-induced dye uncoupling in rat cortical astrocytes is mediated by arachidonic acid byproducts. Brain Research. 816: 411-23. PMID 9878857 DOI: 10.1016/S0006-8993(98)01016-6  0.399
1998 Sáez JC, Martínez AD, Brañes MC, González HE. Regulation of gap junctions by protein phosphorylation. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Mã©Dicas E Biolã³Gicas / Sociedade Brasileira De Biofã­Sica ... [Et Al.]. 31: 593-600. PMID 9698763 DOI: 10.1590/S0100-879X1998000500001  0.455
1998 Eugenín EA, González H, Sáez CG, Sáez JC. Gap junctional communication coordinates vasopressin-induced glycogenolysis in rat hepatocytes. The American Journal of Physiology. 274: G1109-16. PMID 9696712 DOI: 10.1152/Ajpgi.1998.274.6.G1109  0.418
1997 Sáez JC, Nairn AC, Czernik AJ, Fishman GI, Spray DC, Hertzberg EL. Phosphorylation of connexin43 and the regulation of neonatal rat cardiac myocyte gap junctions. Journal of Molecular and Cellular Cardiology. 29: 2131-45. PMID 9281445 DOI: 10.1006/Jmcc.1997.0447  0.374
1997 Sáez JC. Intercellular gap junctional communication is required for an optimal metabolic response of the functional units of liver. Hepatology (Baltimore, Md.). 25: 775-6. PMID 9049235 DOI: 10.1002/Hep.510250348  0.332
1996 Tan IP, Roy C, Sáez JC, Sáez CG, Paul DL, Risley MS. Regulated assembly of connexin33 and connexin43 into rat Sertoli cell gap junctions. Biology of Reproduction. 54: 1300-10. PMID 8724358 DOI: 10.1095/Biolreprod54.6.1300  0.394
1996 Hofer A, Sáez JC, Chang CC, Trosko JE, Spray DC, Dermietzel R. C-erbB2/neu transfection induces gap junctional communication incompetence in glial cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 4311-21. PMID 8699242 DOI: 10.1523/Jneurosci.16-14-04311.1996  0.465
1995 Fallon MB, Nathanson MH, Mennone A, Sáez JC, Burgstahler AD, Anderson JM. Altered expression and function of hepatocyte gap junctions after common bile duct ligation in the rat. The American Journal of Physiology. 268: C1186-94. PMID 7762611 DOI: 10.1152/Ajpcell.1995.268.5.C1186  0.304
1995 Jara PI, Boric MP, Sáez JC. Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion. Proceedings of the National Academy of Sciences of the United States of America. 92: 7011-5. PMID 7624360 DOI: 10.1073/Pnas.92.15.7011  0.437
1995 Kwak BR, Sáez JC, Wilders R, Chanson M, Fishman GI, Hertzberg EL, Spray DC, Jongsma HJ. Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels. Pflã¼Gers Archiv : European Journal of Physiology. 430: 770-8. PMID 7478932 DOI: 10.1007/Bf00386175  0.428
1995 Barrio LC, Jarillo JA, Beyer EC, Saéz JC. Comparison of Voltage Dependence of Chick Connexin 42 and 45 Channels Expressed in Pairs of Xenopus Oocytes Progress in Cell Research. 4: 391-394. DOI: 10.1016/B978-0-444-81929-1.50080-0  0.389
1994 Moreno AP, Sáez JC, Fishman GI, Spray DC. Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circulation Research. 74: 1050-7. PMID 7514508 DOI: 10.1161/01.Res.74.6.1050  0.457
1993 Berthoud VM, Sáez JC. Changes in connexin43, the gap junction protein of astrocytes, during development of the rat pineal gland. Journal of Pineal Research. 14: 67-72. PMID 8391576 DOI: 10.1111/J.1600-079X.1993.Tb00487.X  0.349
1993 Berthoud VM, Rook MB, Traub O, Hertzberg EL, Sáez JC. On the mechanisms of cell uncoupling induced by a tumor promoter phorbol ester in clone 9 cells, a rat liver epithelial cell line. European Journal of Cell Biology. 62: 384-96. PMID 7925494  0.375
1992 Berthoud VM, Iwanij V, Garcia AM, Sáez JC. Connexins and glucagon receptors during development of rat hepatic acinus. The American Journal of Physiology. 263: G650-8. PMID 1332499 DOI: 10.1152/Ajpgi.1992.263.5.G650  0.335
1992 Berthoud VM, Ledbetter ML, Hertzberg EL, Sáez JC. Connexin43 in MDCK cells: regulation by a tumor-promoting phorbol ester and Ca2+. European Journal of Cell Biology. 57: 40-50. PMID 1322299  0.326
1991 Bennett MV, Barrio LC, Bargiello TA, Spray DC, Hertzberg E, Sáez JC. Gap junctions: new tools, new answers, new questions. Neuron. 6: 305-20. PMID 1848077 DOI: 10.1016/0896-6273(91)90241-Q  0.507
1991 Sáez JC, Berthoud VM, Kadle R, Traub O, Nicholson BJ, Bennett MV, Dermietzel R. Pinealocytes in rats: connexin identification and increase in coupling caused by norepinephrine. Brain Research. 568: 265-75. PMID 1667618 DOI: 10.1016/0006-8993(91)91407-R  0.516
1990 Sáez JC, Nairn AC, Czernik AJ, Spray DC, Hertzberg EL, Greengard P, Bennett MV. Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II. European Journal of Biochemistry / Febs. 192: 263-73. PMID 2170122 DOI: 10.1111/J.1432-1033.1990.Tb19223.X  0.479
1989 Sáez JC, Connor JA, Spray DC, Bennett MV. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions. Proceedings of the National Academy of Sciences of the United States of America. 86: 2708-12. PMID 2784857 DOI: 10.1073/Pnas.86.8.2708  0.514
1989 Sáez JC, Gregory WA, Watanabe T, Dermietzel R, Hertzberg EL, Reid L, Bennett MV, Spray DC. cAMP delays disappearance of gap junctions between pairs of rat hepatocytes in primary culture. The American Journal of Physiology. 257: C1-11. PMID 2546432 DOI: 10.1152/Ajpcell.1989.257.1.1-A  0.517
1988 Bennett MV, Saez JC, Spray DC. Multiplicity of controls of gap junctional communication. Puerto Rico Health Sciences Journal. 7: 126, 131-2. PMID 2460885  0.391
1987 Fujita M, Spray DC, Choi H, Saez JC, Watanabe T, Rosenberg LC, Hertzberg EL, Reid LM. Glycosaminoglycans and proteoglycans induce gap junction expression and restore transcription of tissue-specific mRNAs in primary liver cultures. Hepatology (Baltimore, Md.). 7: 1S-9S. PMID 3804212 DOI: 10.1002/Hep.1840070702  0.352
1987 Sáez JC, Bennett MV, Spray DC. Carbon tetrachloride at hepatotoxic levels blocks reversibly gap junctions between rat hepatocytes. Science (New York, N.Y.). 236: 967-9. PMID 3576214 DOI: 10.1126/Science.3576214  0.543
1987 Sáez JC, Kessler JA, Bennett MV, Spray DC. Superoxide dismutase protects cultured neurons against death by starvation. Proceedings of the National Academy of Sciences of the United States of America. 84: 3056-9. PMID 3472251 DOI: 10.1073/Pnas.84.9.3056  0.529
1987 Spray DC, Fujita M, Saez JC, Choi H, Watanabe T, Hertzberg E, Rosenberg LC, Reid LM. Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures. The Journal of Cell Biology. 105: 541-51. PMID 2886511 DOI: 10.1083/Jcb.105.1.541  0.412
1986 Saez JC, Spray DC, Nairn AC, Hertzberg E, Greengard P, Bennett MV. cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide. Proceedings of the National Academy of Sciences of the United States of America. 83: 2473-7. PMID 3010311 DOI: 10.1073/Pnas.83.8.2473  0.533
1986 Spray DC, Saez JC, Brosius D, Bennett MV, Hertzberg EL. Isolated liver gap junctions: gating of transjunctional currents is similar to that in intact pairs of rat hepatocytes. Proceedings of the National Academy of Sciences of the United States of America. 83: 5494-7. PMID 2426699 DOI: 10.1073/Pnas.83.15.5494  0.51
1984 Kessler JA, Spray DC, Saez JC, Bennett MV. Determination of synaptic phenotype: insulin and cAMP independently initiate development of electrotonic coupling between cultured sympathetic neurons. Proceedings of the National Academy of Sciences of the United States of America. 81: 6235-9. PMID 6091144 DOI: 10.1073/Pnas.81.19.6235  0.484
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