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Kenner C. Rice, Ph.D. - Publications

Affiliations: 
Drug Design and Synthesis Section, Chemical Biology Research Branch National Institute on Drug Abuse 
Area:
medicinal chemistry, drugs of abuse
Website:
http://irp.drugabuse.gov/Rice.html
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Year Citation  Score
2020 Carranza-Aguilar CJ, Hernández-Mendoza A, Mejias-Aponte C, Rice KC, Morales M, González-Espinosa C, Cruz SL. Morphine and Fentanyl Repeated Administration Induces Different Levels of NLRP3-Dependent Pyroptosis in the Dorsal Raphe Nucleus of Male Rats via Cell-Specific Activation of TLR4 and Opioid Receptors. Cellular and Molecular Neurobiology. PMID 32926257 DOI: 10.1007/S10571-020-00957-5  0.399
2020 Medina-Rodriguez EM, Rice KC, Beurel E, Jope RS. (+)-Naloxone blocks Toll-like receptor 4 to ameliorate deleterious effects of stress on male mouse behaviors. Brain, Behavior, and Immunity. PMID 32860941 DOI: 10.1016/J.Bbi.2020.08.022  0.318
2020 Green-Fulgham SM, Ball JB, Maier SF, Rice KC, Watkins LR, Grace PM. Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists. Journal of Neuroscience Research. PMID 32533604 DOI: 10.1002/Jnr.24645  0.346
2020 Wang M, Irvin TC, Herdman CA, Hanna RD, Hassan SA, Lee YS, Kaska S, Crowley RS, Prisinzano TE, Withey SL, Paronis CA, Bergman J, Inan S, Geller EB, Adler MW, ... ... Rice KC, et al. The Intriguing Effects of Substituents in the -Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of "Tail Wags Dog" Experiments. Molecules (Basel, Switzerland). 25. PMID 32517185 DOI: 10.3390/Molecules25112640  0.815
2020 Dripps IJ, Chen R, Shafer AM, Livingston KE, Disney A, Husbands SM, Traynor JR, Rice KC, Jutkiewicz EM. Pharmacological Properties of Delta Opioid Receptor-Mediated Behaviors: Agonist Efficacy and Receptor Reserve. The Journal of Pharmacology and Experimental Therapeutics. PMID 32467352 DOI: 10.1124/Jpet.119.262717  0.422
2020 Robertson SA, Hutchinson MR, Rice KC, Chin PY, Moldenhauer LM, Stark MJ, Olson DM, Keelan JA. Targeting Toll-like receptor-4 to tackle preterm birth and fetal inflammatory injury. Clinical & Translational Immunology. 9: e1121. PMID 32313651 DOI: 10.1002/Cti2.1121  0.503
2020 Chen Y, Moutal A, Navratilova E, Kopruszinski C, Yue X, Ikegami M, Chow M, Kanazawa I, Bellampalli SS, Xie J, Patwardhan A, Rice K, Fields H, Akopian A, Neugebauer V, et al. Erratum: The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females (Science Translational Medicine DOI: 10.1126/scitranslmed.aay7550) Science Translational Medicine. 12. PMID 32132219 DOI: 10.1126/Scitranslmed.Abb4549  0.363
2020 Hyatt WS, Hirsh CE, Russell LN, Chitre NM, Murnane KS, Rice KC, Fantegrossi WE. The synthetic cathinone 3,4-methylenedioxypyrovalerone increases impulsive action in rats. Behavioural Pharmacology. PMID 32101987 DOI: 10.1097/Fbp.0000000000000548  0.623
2020 Wahid HH, Chin PY, Sharkey DJ, Diener KR, Hutchinson MR, Rice KC, Moldenhauer LM, Robertson SA. Toll-like receptor-4 antagonist (+)-naltrexone protects against carbamyl-platelet activating factor (Cpaf)-induced preterm labor in mice. The American Journal of Pathology. PMID 32084361 DOI: 10.1016/J.Ajpath.2020.01.008  0.509
2020 Chen Y, Moutal A, Navratilova E, Kopruszinski C, Yue X, Ikegami M, Chow M, Kanazawa I, Bellampalli SS, Xie J, Patwardhan A, Rice K, Fields H, Akopian A, Neugebauer V, et al. The prolactin receptor long isoform regulates nociceptor sensitization and opioid-induced hyperalgesia selectively in females. Science Translational Medicine. 12. PMID 32024801 DOI: 10.1126/Scitranslmed.Aay7550  0.314
2020 Gyawali U, Martin DA, Sulima A, Rice KC, Calu DJ. Role of BNST CRFR1 Receptors in Incubation of Fentanyl Seeking Frontiers in Behavioral Neuroscience. 14. DOI: 10.3389/Fnbeh.2020.00153  0.337
2020 Burgess GE, Polt R, Rice KC, Jutkiewicz EM. Characterization of Delta Opioid Receptor Activity of MMP2200, a Mixed Efficacy Mu and Delta Opioid Receptor Agonist The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05714  0.386
2019 Fulenwider HD, Nennig SE, Hafeez H, Price ME, Baruffaldi F, Pravetoni M, Cheng K, Rice KC, Manvich DF, Schank JR. Sex differences in oral oxycodone self-administration and stress-primed reinstatement in rats. Addiction Biology. e12822. PMID 31830773 DOI: 10.1111/Adb.12822  0.356
2019 Arttamangkul S, Plazek A, Platt EJ, Jin H, Murray TF, Birdsong W, Rice KC, Farrens D, Williams JT. Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry. Elife. 8. PMID 31589142 DOI: 10.7554/Elife.49319  0.383
2019 Chin PY, Dorian C, Sharkey DJ, Hutchinson MR, Rice KC, Moldenhauer LM, Robertson SA. Toll-like receptor-4 antagonist (+)-naloxone confers sexually dimorphic protection from inflammation-induced fetal programming in mice. Endocrinology. PMID 31504393 DOI: 10.1210/En.2019-00493  0.514
2019 Wang X, Northcutt AL, Cochran TA, Zhang X, Fabisiak TJ, Haas ME, Amat J, Li H, Rice KC, Maier S, Bachtell RK, Hutchinson MR, Watkins LR. Methamphetamine activates Toll-like receptor 4 to induce central immune signaling within the ventral tegmental area and contributes to extracellular dopamine increase in the nucleus accumbens shell. Acs Chemical Neuroscience. PMID 31282647 DOI: 10.1021/Acschemneuro.9B00225  0.56
2019 Hyatt WS, Berquist MD, Chitre NM, Russell LN, Rice KC, Murnane KS, Fantegrossi WE. Repeated administration of synthetic cathinone 3,4-methylenedioxypyrovalerone persistently increases impulsive choice in rats. Behavioural Pharmacology. PMID 31211703 DOI: 10.1097/Fbp.0000000000000492  0.629
2019 Ray A, Canal CE, Ehlen JC, Rice KC, Murnane KS. M100907 and BD 1047 Attenuate the Acute Toxic Effects of Methamphetamine. Neurotoxicology. PMID 31163210 DOI: 10.1016/J.Neuro.2019.05.011  0.345
2019 Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201900173RRR. PMID 31162938 DOI: 10.1096/Fj.201900173Rrr  0.536
2019 Luethi D, Kolaczynska KE, Walter M, Suzuki M, Rice KC, Blough BE, Hoener MC, Baumann MH, Liechti ME. Metabolites of the ring-substituted stimulants MDMA, methylone and MDPV differentially affect human monoaminergic systems. Journal of Psychopharmacology (Oxford, England). 269881119844185. PMID 31038382 DOI: 10.1177/0269881119844185  0.301
2019 Murnane KS, Guner OF, Bowen JP, Rambacher KM, Moniri NH, Murphy TJ, Daphney CM, Oppong-Damoah A, Rice KC. The adrenergic receptor antagonist carvedilol interacts with serotonin 2A receptors both in vitro and in vivo. Pharmacology, Biochemistry, and Behavior. PMID 30998954 DOI: 10.1016/J.Pbb.2019.04.003  0.346
2019 Cai NS, Quiroz C, Bonaventura J, Bonifazi A, Cole TO, Purks J, Billing AS, Massey E, Wagner M, Wish ED, Guitart X, Rea W, Lam S, Moreno E, Casadó-Anguera V, ... ... Rice KC, et al. Opioid-galanin receptor heteromers mediate the dopaminergic effects of opioids. The Journal of Clinical Investigation. 130. PMID 30913037 DOI: 10.1172/Jci126912  0.579
2019 Schindler CW, Thorndike EC, Rice KC, Partilla JS, Baumann MH. The supplement adulterant β-methylphenethylamine (BMPEA, 2-phenylpropan-1-amine) increases blood pressure by acting at peripheral norepinephrine transporters. The Journal of Pharmacology and Experimental Therapeutics. PMID 30898867 DOI: 10.1124/Jpet.118.255976  0.363
2019 Schwienteck KL, Faunce KE, Rice KC, Obeng S, Zhang Y, Blough BE, Grim TW, Stevens Negus S, Banks ML. Effectiveness comparisons of G-protein biased and unbiased mu opioid receptor ligands in warm water tail-withdrawal and drug discrimination in male and female rats. Neuropharmacology. PMID 30660628 DOI: 10.1016/J.Neuropharm.2019.01.020  0.404
2019 Cornelissen JC, Steele FF, Tenney RD, Obeng S, Rice KC, Zhang Y, Banks ML. Role of mu-opioid agonist efficacy on antinociceptive interactions between mu agonists and the nociceptin opioid peptide agonist Ro 64-6198 in rhesus monkeys. European Journal of Pharmacology. 844: 175-182. PMID 30552903 DOI: 10.1016/J.Ejphar.2018.12.021  0.405
2019 Odabas-Geldiay M, Shields H, Berro LF, Rice KC, Howell LL. Effects of acute treatments with the serotonin 2A antagonist M100907 alone or in combination with the serotonin 2C agonist WAY163909 on methamphetamine self-administration in rhesus monkeys. Drug and Alcohol Dependence. 194: 252-256. PMID 30469095 DOI: 10.1016/J.Drugalcdep.2018.10.018  0.353
2019 Arttamangkul S, Plazek A, Platt EJ, Jin H, Murray TF, Birdsong WT, Rice KC, Farrens DL, Williams JT. Author response: Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry Elife. DOI: 10.7554/Elife.49319.028  0.334
2018 Sholler DJ, Stutz SJ, Fox RG, Boone EL, Wang Q, Rice KC, Moeller FG, Anastasio NC, Cunningham KA. The 5-HT Receptor (5-HTR) Regulates Impulsive Action and Cocaine Cue Reactivity in Male Sprague-Dawley Rats. The Journal of Pharmacology and Experimental Therapeutics. PMID 30373886 DOI: 10.1124/Jpet.118.251199  0.32
2018 Guo M, Gao ZG, Tyler R, Stodden T, Li Y, Ramsey J, Zhao WJ, Wang GJ, Wiers CE, Fowler JS, Rice KC, Jacobson KA, Kim SW, Volkow ND. Preclinical evaluation of the first adenosine A receptor partial agonist radioligand for positron emission tomography (PET) imaging. Journal of Medicinal Chemistry. PMID 30359014 DOI: 10.1021/Acs.Jmedchem.8B01009  0.303
2018 Uhl GR, Martinez MJ, Paik P, Sulima A, Bi GH, Iyer MR, Gardner E, Rice KC, Xi ZX. Cocaine reward is reduced by decreased expression of receptor-type protein tyrosine phosphatase D (PTPRD) and by a novel PTPRD antagonist. Proceedings of the National Academy of Sciences of the United States of America. PMID 30348770 DOI: 10.1073/Pnas.1720446115  0.326
2018 Gannon BM, Baumann MH, Walther D, Jimenez-Morigosa C, Sulima A, Rice KC, Collins GT. The abuse-related effects of pyrrolidine-containing cathinones are related to their potency and selectivity to inhibit the dopamine transporter. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 43: 2399-2407. PMID 30305739 DOI: 10.1038/S41386-018-0209-3  0.649
2018 Gannon BM, Mesmin MP, Sulima A, Rice KC, Collins GT. Behavioral economic analysis of the reinforcing effects of "bath salts" mixtures: studies with MDPV, methylone, and caffeine in male Sprague-Dawley rats. Psychopharmacology. PMID 30267131 DOI: 10.1007/S00213-018-5046-X  0.611
2018 Cone K, Lanpher J, Kinens A, Richard P, Couture S, Brackin R, Payne E, Harrington K, Rice KC, Stevenson GW. Delta/mu opioid receptor interactions in operant conditioning assays of pain-depressed responding and drug-induced rate suppression: assessment of therapeutic index in male Sprague Dawley rats. Psychopharmacology. PMID 29572653 DOI: 10.1007/S00213-018-4876-X  0.32
2018 Gilbertson SR, Chen YC, Soto CA, Yang Y, Rice KC, Cunningham KA, Anastasio NC. Synthesis and activity of functionalizable derivatives of the serotonin (5-HT) 5-HTreceptor (5-HTR) antagonist M100907. Bioorganic & Medicinal Chemistry Letters. PMID 29555153 DOI: 10.1016/J.Bmcl.2018.02.058  0.346
2018 Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X. Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists. Journal of Chemical Information and Modeling. PMID 29518316 DOI: 10.1021/Acs.Jcim.7B00717  0.576
2018 Elmore JS, Decker AM, Sulima A, Rice KC, Partilla JS, Blough BE, Baumann MH. Comparative neuropharmacology of N-(2-methoxybenzyl)-2,5-dimethoxyphenethylamine (NBOMe) hallucinogens and their 2C counterparts in male rats. Neuropharmacology. PMID 29501528 DOI: 10.1016/J.Neuropharm.2018.02.033  0.327
2018 Fulenwider HD, Smith BM, Nichenko AS, Carpenter JM, Nennig SE, Cheng K, Rice KC, Schank JR. Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation. Journal of Neuroinflammation. 15: 60. PMID 29486768 DOI: 10.1186/S12974-018-1098-4  0.308
2018 Cornelissen JC, Obeng S, Rice KC, Zhang Y, Negus SS, Banks M. Application of receptor theory to the design and use of fixed-proportion mu-opioid agonist and antagonist mixtures in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. PMID 29330156 DOI: 10.1124/Jpet.117.246439  0.413
2017 Dripps IJ, Boyer BT, Neubig RR, Rice KC, Traynor JR, Jutkiewicz EM. Role of signaling molecules in behaviors mediated by the δ-receptor agonist SNC80. British Journal of Pharmacology. PMID 29278419 DOI: 10.1111/Bph.14131  0.351
2017 Cornelissen JC, Steele FF, Rice KC, Nicholson KL, Banks ML. Additive and subadditive antiallodynic interactions between μ-opioid agonists and N-methyl D-aspartate antagonists in male rhesus monkeys. Behavioural Pharmacology. PMID 29239974 DOI: 10.1097/Fbp.0000000000000336  0.403
2017 Sulima A, Jalah R, Antoline JFG, Torres OB, Imler GH, Deschamps JR, Beck Z, Alving CR, Jacobson AE, Rice KC, Matyas GR. A Stable Heroin Analogue That Can Serve as a Vaccine Hapten to Induce Antibodies That Block the Effects of Heroin and Its Metabolites in Rodents and That Cross-React Immunologically with Related Drugs of Abuse. Journal of Medicinal Chemistry. PMID 29236495 DOI: 10.1021/Acs.Jmedchem.7B01427  0.303
2017 Gannon BM, Sulima A, Rice KC, Collins GT. Inhibition of cocaine and 3,4-methylenedioxypyrovalerone (MDPV) self-administration by lorcaserin is mediated by 5-HT2C receptors in rats. The Journal of Pharmacology and Experimental Therapeutics. PMID 29217539 DOI: 10.1124/Jpet.117.246082  0.667
2017 Soto CA, Shashack MJ, Fox RG, Bubar MJ, Rice KC, Watson CS, Cunningham KA, Gilbertson SR, Anastasio NC. Novel Bivalent 5-HT2A Receptor Antagonists Exhibit High Affinity and Potency in Vitro and Efficacy in Vivo. Acs Chemical Neuroscience. PMID 29111677 DOI: 10.1021/Acschemneuro.7B00309  0.384
2017 Clasen MM, Flax SM, Hempel BJ, Cheng K, Rice KC, Riley AL. Antagonism of the kappa opioid receptor attenuates THC-induced place aversions in adult male Sprague-Dawley rats. Pharmacology, Biochemistry, and Behavior. PMID 29100992 DOI: 10.1016/J.Pbb.2017.10.010  0.422
2017 Moerke MJ, Banks ML, Cheng K, Rice KC, Negus SS. Maintenance on naltrexone+amphetamine decreases cocaine-vs.-food choice in male rhesus monkeys. Drug and Alcohol Dependence. 181: 85-93. PMID 29040826 DOI: 10.1016/J.Drugalcdep.2017.09.020  0.37
2017 Jacobsen JH, Buisman-Pijlman F, Mustafa S, Rice KC, Hutchinson MR. Antagonising TLR4-TRIF signalling before or after a low-dose alcohol binge during adolescence prevents alcohol drinking but not seeking behaviour in adulthood. Neuropharmacology. PMID 28947376 DOI: 10.1016/J.Neuropharm.2017.09.028  0.474
2017 Gannon BM, Williamson A, Rice KC, Fantegrossi WE. Role of monoaminergic systems and ambient temperature in bath salts constituent 3,4-methylenedioxypyrovalerone (MDPV) elicited hyperthermia and locomotor stimulation in mice. Neuropharmacology. PMID 28887185 DOI: 10.1016/J.Neuropharm.2017.09.004  0.742
2017 Gannon BM, Russell LN, Modi MS, Rice KC, Fantegrossi WE. Effects of orally self-administered bath salt constituent 3,4-methylenedioxypyrovalerone (MDPV) in mice. Drug and Alcohol Dependence. 179: 408-415. PMID 28866386 DOI: 10.1016/J.Drugalcdep.2017.06.031  0.731
2017 Jacobsen JHW, Buisman-Pijlman FT, Mustafa S, Rice KC, Hutchinson MR. The efficacy of (+)-Naltrexone on alcohol preference and seeking behaviour is dependent on light-cycle. Brain, Behavior, and Immunity. PMID 28864261 DOI: 10.1016/J.Bbi.2017.08.021  0.513
2017 Grace PM, Strand KA, Galer EL, Rice KC, Maier SF, Watkins LR. Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats. Brain, Behavior, and Immunity. PMID 28860068 DOI: 10.1016/J.Bbi.2017.08.018  0.368
2017 Micioni Di Bonaventura MV, Ubaldi M, Giusepponi ME, Rice KC, Massi M, Ciccocioppo R, Cifani C. Hypothalamic CRF1 receptor mechanisms are not sufficient to account for binge-like palatable food consumption in female rats. The International Journal of Eating Disorders. PMID 28833350 DOI: 10.1002/Eat.22767  0.333
2017 Gannon BM, Galindo KI, Mesmin MP, Sulima A, Rice KC, Collins GT. Relative reinforcing effects of second-generation synthetic cathinones: Acquisition of self-administration and fixed ratio dose-response curves in rats. Neuropharmacology. PMID 28811192 DOI: 10.1016/J.Neuropharm.2017.08.018  0.628
2017 Lantz SM, Rosas-Hernandez H, Cuevas E, Robinson B, Rice KC, Fantegrossi WE, Imam SZ, Paule MG, Ali SF. Monoaminergic toxicity induced by cathinone phthalimide: an in vitro study. Neuroscience Letters. PMID 28684237 DOI: 10.1016/J.Neulet.2017.06.059  0.621
2017 Gannon BM, Galindo KI, Mesmin MP, Rice KC, Collins GT. Reinforcing Effects of Binary Mixtures of Common bath salts Constituents: Studies with 3,4-Methylenedioxypyrovalerone (MDPV), 3,4-Methylenedioxymethcathinone (Methylone), and Caffeine in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28677665 DOI: 10.1038/Npp.2017.141  0.634
2017 Gannon BM, Rice KC, Collins GT. Reinforcing effects of abused 'bath salts' constituents 3,4-methylenedioxypyrovalerone and α-pyrrolidinopentiophenone and their enantiomers. Behavioural Pharmacology. PMID 28570297 DOI: 10.1097/Fbp.0000000000000315  0.617
2017 Pitts EG, Minerva AR, Oliver EB, Kohn JN, Logun MT, Sulima A, Rice KC, Howell LL. 3,4-Methylenedioxymethamphetamine Increases Affiliative Behaviors in Squirrel Monkeys in a Serotonin 2A Receptor-Dependent Manner. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28425496 DOI: 10.1038/Npp.2017.80  0.327
2017 Gannon BM, Galindo KI, Rice KC, Collins GT. Individual differences in the relative reinforcing effects of 3,4-methylenedioxypyrovalerone (MDPV) under fixed and progressive ratio schedules of reinforcement in rats. The Journal of Pharmacology and Experimental Therapeutics. PMID 28179474 DOI: 10.1124/Jpet.116.239376  0.63
2017 Gannon BM, Galindo K, Rice K, Collins GT. Stereoselective differences in the reinforcing effects of “bath salts” constituent 3,4-methylenedioxypyrovalerone under a progressive ratio schedule of reinforcement in rats Drug and Alcohol Dependence. 171: e68. DOI: 10.1016/J.Drugalcdep.2016.08.197  0.605
2017 Collins GT, Gannon BM, Rice K. 3,4-Methylenedioxypyrovalerone maintains differential patterns of responding in male Sprague-Dawley rats Drug and Alcohol Dependence. 171: e43. DOI: 10.1016/J.Drugalcdep.2016.08.131  0.591
2016 Perez Diaz M, Andersen ML, Rice KC, Howell LL. Effects of a Serotonin 2C Agonist and a 2A Antagonist on Actigraphy-Based Sleep Parameters Disrupted by Methamphetamine Self-Administration in Rhesus Monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27986974 DOI: 10.1038/Npp.2016.280  0.312
2016 Baumann MH, Bukhari MO, Lehner KR, Anizan S, Rice KC, Concheiro M, Huestis MA. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs. Current Topics in Behavioral Neurosciences. PMID 27830575 DOI: 10.1007/7854_2016_53  0.334
2016 Chin PY, Dorian CL, Hutchinson MR, Olson DM, Rice KC, Moldenhauer LM, Robertson SA. Novel Toll-like receptor-4 antagonist (+)-naloxone protects mice from inflammation-induced preterm birth. Scientific Reports. 6: 36112. PMID 27819333 DOI: 10.1038/Srep36112  0.538
2016 Elmore J, Dillon-Carter O, Partilla J, Ellefsen KN, Concheiro M, Suzuki M, Rice KC, Huestis MA, Baumann MH. Pharmacokinetic Profiles and Pharmacodynamic Effects for Methylone and its Metabolites in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27658484 DOI: 10.1038/Npp.2016.213  0.32
2016 Serafine KM, Rice KC, France CP. Characterization of the discriminative stimulus effects of lorcaserin in rats. Journal of the Experimental Analysis of Behavior. PMID 27640338 DOI: 10.1002/Jeab.222  0.4
2016 Ellis A, Grace PM, Wieseler J, Favret J, Springer K, Skarda B, Hutchinson MR, Falci S, Rice KC, Maier SF, Watkins LR. Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury. Brain, Behavior, and Immunity. PMID 27519154 DOI: 10.1016/J.Bbi.2016.08.004  0.539
2016 Collins GT, Abbott M, Galindo K, Rush EL, Rice KC, France CP. Discriminative stimulus effects of binary drug mixtures: studies with cocaine, MDPV, and caffeine. The Journal of Pharmacology and Experimental Therapeutics. PMID 27493274 DOI: 10.1124/Jpet.116.234252  0.301
2016 Rosas-Hernandez H, Cuevas E, Lantz SM, Rice KC, Gannon BM, Fantegrossi WE, Gonzalez C, Paule MG, Ali SF. Methamphetamine, 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxypyrovalerone (MDPV) induce differential cytotoxic effects in bovine brain microvessel endothelial cells. Neuroscience Letters. PMID 27320055 DOI: 10.1016/J.Neulet.2016.06.029  0.728
2016 Eriksen GS, Andersen JM, Boix FE, Bergh MS, Vindenes V, Rice KC, Huestis MA, Morland J. Comparison of (+) and (-)-naloxone on the acute psychomotor stimulating effects of heroin, 6-acetylmorphine, and morphine in mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 27278234 DOI: 10.1124/Jpet.116.233544  0.391
2016 Grace PM, Strand KA, Galer EL, Urban DJ, Wang X, Baratta MV, Fabisiak TJ, Anderson ND, Cheng K, Greene LI, Berkelhammer D, Zhang Y, Ellis AL, Yin HH, Campeau S, ... Rice KC, et al. Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247388 DOI: 10.1073/Pnas.1602070113  0.326
2016 Katz JL, Hiranita T, Kopajtic TA, Rice KC, Mesangeau C, Narayanan S, Abdelazeem AH, McCurdy CR. Blockade of Cocaine or Sigma Receptor Agonist Self-Administration by Subtype- Selective Sigma Receptor Antagonists. The Journal of Pharmacology and Experimental Therapeutics. PMID 27189970 DOI: 10.1124/Jpet.116.232728  0.359
2016 Saccone PA, Zelenock KA, Linsdey AM, Sulima A, Rice KC, Prinssen EP, Wichmann J, Woods JH. Characterization of the discriminative stimulus effects of a NOP receptor agonist Ro 64-6198 in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. PMID 26801398 DOI: 10.1124/Jpet.115.231134  0.376
2016 Gannon BM, Williamson A, Suzuki M, Rice KC, Fantegrossi WE. Stereoselective Effects of Abused "Bath Salt" Constituent 3,4-Methylenedioxypyrovalerone in Mice: Drug Discrimination, Locomotor Activity, and Thermoregulation. The Journal of Pharmacology and Experimental Therapeutics. 356: 615-23. PMID 26769917 DOI: 10.1124/Jpet.115.229500  0.742
2016 Rosas-Hernandez H, Cuevas E, Lantz SM, Imam SZ, Rice KC, Gannon BM, Fantegrossi WE, Paule MG, Ali SF. 3,4-methylenedioxypyrovalerone (MDPV) Induces Cytotoxic Effects on Human Dopaminergic SH-SY5Y Cells Journal of Drug and Alcohol Research. 5: 1-6. DOI: 10.4303/JDAR/235991  0.701
2016 Gannon BM, Williamson A, Suzuki M, Rice KC, Fantegrossi WE. Stereoselective effects of abused "bath salt" constituent 3,4-methylenedioxypyrovalerone in mice: Drug discrimination, locomotor activity, and thermoregulation Journal of Pharmacology and Experimental Therapeutics. 356: 615-623. DOI: 10.1124/jpet.115.229500  0.711
2015 Wang X, Zhang Y, Peng Y, Hutchinson MR, Rice KC, Yin H, Watkins LR. Pharmacological characterization of the opioid inactive isomers (+)-naltrexone and (+)-naloxone as Toll-like receptor 4 antagonists. British Journal of Pharmacology. PMID 26603732 DOI: 10.1111/Bph.13394  0.584
2015 Serafine KM, Rice KC, France CP. Directly Observable Behavioral Effects of Lorcaserin in Rats. The Journal of Pharmacology and Experimental Therapeutics. 355: 381-5. PMID 26384326 DOI: 10.1124/Jpet.115.228148  0.414
2015 Wahid HH, Dorian C, Yin Chin P, Hutchinson MR, Rice KC, Olson DM, Moldenhauer LM, Robertson SA. Toll-like receptor 4 is an essential upstream regulator of on-time parturition and perinatal viability in mice. Endocrinology. EN20151089. PMID 26151355 DOI: 10.1210/En.2015-1089  0.508
2015 Flax SM, Wakeford AG, Cheng K, Rice KC, Riley AL. Effect of norbinaltorphimine on ∆(9)-tetrahydrocannabinol (THC)-induced taste avoidance in adolescent and adult Sprague-Dawley rats. Psychopharmacology. PMID 26025420 DOI: 10.1007/S00213-015-3970-6  0.322
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the Toll of Drug Abuse: The Translational Potential of Toll-Like Receptor 4. Cns & Neurological Disorders Drug Targets. 14: 692-9. PMID 26022268 DOI: 10.2174/1871527314666150529132503  0.56
2015 Selfridge BR, Wang X, Zhang Y, Yin H, Grace PM, Watkins LR, Jacobson AE, Rice KC. Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists. Journal of Medicinal Chemistry. 58: 5038-52. PMID 26010811 DOI: 10.1021/Acs.Jmedchem.5B00426  0.394
2015 Fink LH, Anastasio NC, Fox RG, Rice KC, Moeller FG, Cunningham KA. Individual Differences in Impulsive Action Reflect Variation in the Cortical Serotonin 5-HT2A Receptor System. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1957-68. PMID 25666313 DOI: 10.1038/Npp.2015.46  0.334
2015 Northcutt AL, Hutchinson MR, Wang X, Baratta MV, Hiranita T, Cochran TA, Pomrenze MB, Galer EL, Kopajtic TA, Li CM, Amat J, Larson G, Cooper DC, Huang Y, O'Neill CE, ... ... Rice KC, et al. DAT isn't all that: cocaine reward and reinforcement require Toll-like receptor 4 signaling. Molecular Psychiatry. PMID 25644383 DOI: 10.1038/Mp.2014.177  0.527
2015 Iyer MR, Rothman RB, Dersch CM, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena 49. N-substituted rac-cis-4a-arylalkyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. European Journal of Medicinal Chemistry. 92: 531-9. PMID 25599950 DOI: 10.1016/J.Ejmech.2015.01.025  0.381
2015 Hutsell BA, Cheng K, Rice KC, Negus SS, Banks ML. Effects of the kappa opioid receptor antagonist nor-binaltorphimine (nor-BNI) on cocaine versus food choice and extended-access cocaine intake in rhesus monkeys. Addiction Biology. PMID 25581305 DOI: 10.1111/Adb.12206  0.315
2015 Corrigan F, Wu Y, Tuke J, Coller JK, Rice KC, Diener KR, Hayball JD, Watkins LR, Somogyi AA, Hutchinson MR. Alcohol-induced sedation and synergistic interactions between alcohol and morphine: a key mechanistic role for Toll-like receptors and MyD88-dependent signaling. Brain, Behavior, and Immunity. 45: 245-52. PMID 25542736 DOI: 10.1016/J.Bbi.2014.12.019  0.532
2015 King HE, Wetzell B, Rice KC, Riley AL. An assessment of MDPV-induced place preference in adult Sprague-Dawley rats. Drug and Alcohol Dependence. 146: 116-9. PMID 25468817 DOI: 10.1016/J.Drugalcdep.2014.11.002  0.325
2015 Altarifi AA, Rice KC, Negus SS. Effects of μ-opioid receptor agonists in assays of acute pain-stimulated and pain-depressed behavior in male rats: role of μ-agonist efficacy and noxious stimulus intensity. The Journal of Pharmacology and Experimental Therapeutics. 352: 208-17. PMID 25406170 DOI: 10.1124/Jpet.114.219873  0.357
2015 Lewis SS, Hutchinson MR, Frick MM, Zhang Y, Maier SF, Sammakia T, Rice KC, Watkins LR. Select steroid hormone glucuronide metabolites can cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 44: 128-36. PMID 25218902 DOI: 10.1016/J.Bbi.2014.09.004  0.547
2015 Carbonaro TM, Eshleman AJ, Forster MJ, Cheng K, Rice KC, Gatch MB. The role of 5-HT2A, 5-HT 2C and mGlu2 receptors in the behavioral effects of tryptamine hallucinogens N,N-dimethyltryptamine and N,N-diisopropyltryptamine in rats and mice. Psychopharmacology. 232: 275-84. PMID 24985890 DOI: 10.1007/S00213-014-3658-3  0.347
2015 Bachtell R, Hutchinson MR, Wang X, Rice KC, Maier SF, Watkins LR. Targeting the toll of drug abuse: The translational potential of toll-like receptor 4 Cns and Neurological Disorders - Drug Targets. 14: 692-698.  0.465
2014 Anizan S, Concheiro M, Lehner KR, Bukhari MO, Suzuki M, Rice KC, Baumann MH, Huestis MA. Linear pharmacokinetics of 3,4-methylenedioxypyrovalerone (MDPV) and its metabolites in the rat: relationship to pharmacodynamic effects. Addiction Biology. PMID 25475011 DOI: 10.1111/Adb.12201  0.307
2014 King HE, Wetzell B, Rice KC, Riley AL. 3,4-methylenedioxypyrovalerone (MDPV)-induced conditioned taste avoidance in the F344/N and LEW rat strains. Pharmacology, Biochemistry, and Behavior. 126: 163-9. PMID 25284129 DOI: 10.1016/J.Pbb.2014.09.021  0.308
2014 Leitl MD, Potter DN, Cheng K, Rice KC, Carlezon WA, Negus SS. Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats. Molecular Pain. 10: 62. PMID 25245060 DOI: 10.1186/1744-8069-10-62  0.301
2014 Grace PM, Ramos KM, Rodgers KM, Wang X, Hutchinson MR, Lewis MT, Morgan KN, Kroll JL, Taylor FR, Strand KA, Zhang Y, Berkelhammer D, Huey MG, Greene LI, Cochran TA, ... ... Rice KC, et al. Activation of adult rat CNS endothelial cells by opioid-induced toll-like receptor 4 (TLR4) signaling induces proinflammatory, biochemical, morphological, and behavioral sequelae. Neuroscience. 280: 299-317. PMID 25241065 DOI: 10.1016/J.Neuroscience.2014.09.020  0.572
2014 Zwicker JD, Zhang Y, Ren J, Hutchinson MR, Rice KC, Watkins LR, Greer JJ, Funk GD. Glial TLR4 signaling does not contribute to opioid-induced depression of respiration. Journal of Applied Physiology (Bethesda, Md. : 1985). 117: 857-68. PMID 25103966 DOI: 10.1152/Japplphysiol.00534.2014  0.572
2014 Selfridge BR, Deschamps JR, Jacobson AE, Rice KC. Synthesis of enantiopure 10-nornaltrexones in the search for Toll-like receptor 4 antagonists and opioid ligands. The Journal of Organic Chemistry. 79: 5007-18. PMID 24773391 DOI: 10.1021/Jo500568S  0.345
2014 Kupchik YM, Scofield MD, Rice KC, Cheng K, Roques BP, Kalivas PW. Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1057-66. PMID 24431463 DOI: 10.1523/Jneurosci.4336-13.2014  0.314
2014 Sukhtankar DD, Lee H, Rice KC, Ko MC. Differential effects of opioid-related ligands and NSAIDs in nonhuman primate models of acute and inflammatory pain Psychopharmacology. 231: 1377-1387. PMID 24217900 DOI: 10.1007/S00213-013-3341-0  0.304
2014 Schank JR, King CE, Sun H, Cheng K, Rice KC, Heilig M, Weinshenker D, Schroeder JP. The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1093-101. PMID 24173499 DOI: 10.1038/Npp.2013.309  0.323
2014 Leitl MD, Onvani S, Bowers MS, Cheng K, Rice KC, Carlezon WA, Banks ML, Negus SS. Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous κ-opioids. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 614-24. PMID 24008352 DOI: 10.1038/Npp.2013.236  0.351
2014 Grace P, Strand K, Galer E, Zhang Y, Berkelhammer D, Greene L, Rice K, Maier S, Watkins L. 31. Therapeutic morphine prolongs neuropathic pain in rats: A role for TLR4 and inflammasome signaling in the lumbar spinal cord Brain, Behavior, and Immunity. 40: e9-e10. DOI: 10.1016/J.Bbi.2014.06.051  0.347
2013 Murnane KS, Winschel J, Schmidt KT, Stewart LM, Rose SJ, Cheng K, Rice KC, Howell LL. Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13367-74. PMID 23946394 DOI: 10.1523/Jneurosci.1437-13.2013  0.347
2013 Altarifi AA, Rice KC, Negus SS. Abuse-related effects of μ-opioid analgesics in an assay of intracranial self-stimulation in rats: Modulation by chronic morphine exposure Behavioural Pharmacology. 24: 459-470. PMID 23881045 DOI: 10.1097/Fbp.0B013E328364C0Bd  0.363
2013 Lim HJ, Dersch CM, Rothman RB, Deschamps JR, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation. European Journal of Medicinal Chemistry. 67: 335-43. PMID 23880358 DOI: 10.1016/J.Ejmech.2013.06.030  0.367
2013 Murnane KS, Andersen ML, Rice KC, Howell LL. Selective serotonin 2A receptor antagonism attenuates the effects of amphetamine on arousal and dopamine overflow in non-human primates. Journal of Sleep Research. 22: 581-8. PMID 23879373 DOI: 10.1111/Jsr.12045  0.324
2013 Gatch MB, Kozlenkov A, Huang RQ, Yang W, Nguyen JD, González-Maeso J, Rice KC, France CP, Dillon GH, Forster MJ, Schetz JA. The HIV antiretroviral drug efavirenz has LSD-like properties. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2373-84. PMID 23702798 DOI: 10.1038/Npp.2013.135  0.355
2013 Iyer MR, Rothman RB, Dersch CM, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 47. Novel C4a- and N-substituted-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols. Bioorganic & Medicinal Chemistry. 21: 3298-309. PMID 23618710 DOI: 10.1016/J.Bmc.2013.02.060  0.358
2013 Birdsong WT, Arttamangkul S, Clark MJ, Cheng K, Rice KC, Traynor JR, Williams JT. Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4118-27. PMID 23447620 DOI: 10.1523/Jneurosci.4187-12.2013  0.408
2013 Briscione MA, Serafine KM, Merluzzi AP, Rice KC, Riley AL. The effects of the 5-HT3 receptor antagonist tropisetron on cocaine-induced conditioned taste aversions. Pharmacology, Biochemistry, and Behavior. 105: 112-7. PMID 23415734 DOI: 10.1016/J.Pbb.2013.02.003  0.339
2013 Theberge FR, Li X, Kambhampati S, Pickens CL, St Laurent R, Bossert JM, Baumann MH, Hutchinson MR, Rice KC, Watkins LR, Shaham Y. Effect of chronic delivery of the Toll-like receptor 4 antagonist (+)-naltrexone on incubation of heroin craving. Biological Psychiatry. 73: 729-37. PMID 23384483 DOI: 10.1016/J.Biopsych.2012.12.019  0.553
2013 Lewis SS, Hutchinson MR, Zhang Y, Hund DK, Maier SF, Rice KC, Watkins LR. Glucuronic acid and the ethanol metabolite ethyl-glucuronide cause toll-like receptor 4 activation and enhanced pain. Brain, Behavior, and Immunity. 30: 24-32. PMID 23348028 DOI: 10.1016/J.Bbi.2013.01.005  0.552
2013 Cunningham KA, Anastasio NC, Fox RG, Stutz SJ, Bubar MJ, Swinford SE, Watson CS, Gilbertson SR, Rice KC, Rosenzweig-Lipson S, Moeller FG. Synergism between a serotonin 5-HT2A receptor (5-HT2AR) antagonist and 5-HT2CR agonist suggests new pharmacotherapeutics for cocaine addiction. Acs Chemical Neuroscience. 4: 110-21. PMID 23336050 DOI: 10.1021/Cn300072U  0.321
2013 Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 976-84. PMID 23303056 DOI: 10.1038/Npp.2012.261  0.366
2013 Koek W, Cheng K, Rice KC. Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: Comparison with GABAB receptor agonists and drugs of abuse Journal of Pharmacology and Experimental Therapeutics. 344: 553-560. PMID 23275067 DOI: 10.1124/Jpet.112.202226  0.322
2013 Fantegrossi WE, Gannon BM, Zimmerman SM, Rice KC. In vivo effects of abused 'bath salt' constituent 3,4- methylenedioxypyrovalerone (MDPV) in mice: Drug discrimination, thermoregulation, and locomotor activity Neuropsychopharmacology. 38: 563-573. PMID 23212455 DOI: 10.1038/Npp.2012.233  0.743
2013 Li JX, Shah AP, Patel SK, Rice KC, France CP. Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HTâ‚‚A receptor agonists: antinociception, drug discrimination, and locomotor activity. Psychopharmacology. 225: 791-801. PMID 22993050 DOI: 10.1007/S00213-012-2870-2  0.387
2013 Grace P, Greene L, Strand K, Rice K, Maier S, Watkins L. 18. Repeated morphine enhances peripheral nerve injury-induced allodynia via central immune mechanisms Brain, Behavior, and Immunity. 32: e5-e6. DOI: 10.1016/J.Bbi.2013.07.030  0.341
2012 Li F, Deck JA, Dersch CM, Rothman RB, Deschamps JR, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 46. N-substituted-2,3,4,9, 10,10a-hexahydro-1H-1,4a-(epiminoethano)phenanthren-6- and 8-ols - Carbocyclic relatives of f-oxide-bridged phenylmorphans European Journal of Medicinal Chemistry. 58: 557-567. PMID 23168379 DOI: 10.1016/J.Ejmech.2012.10.041  0.358
2012 Yekkirala AS, Banks ML, Lunzer MM, Negus SS, Rice KC, Portoghese PS. Clinically employed opioid analgesics produce antinociception via μ-δ opioid receptor heteromers in Rhesus monkeys. Acs Chemical Neuroscience. 3: 720-7. PMID 23019498 DOI: 10.1021/Cn300049M  0.407
2012 Hutchinson MR, Northcutt AL, Hiranita T, Wang X, Lewis SS, Thomas J, van Steeg K, Kopajtic TA, Loram LC, Sfregola C, Galer E, Miles NE, Bland ST, Amat J, Rozeske RR, ... ... Rice KC, et al. Opioid activation of toll-like receptor 4 contributes to drug reinforcement. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11187-200. PMID 22895704 DOI: 10.1523/Jneurosci.0684-12.2012  0.595
2012 Koffarnus MN, Collins GT, Rice KC, Chen J, Woods JH, Winger G. Self-administration of agonists selective for dopamine D2, D3, and D4 receptors by rhesus monkeys. Behavioural Pharmacology. 23: 331-8. PMID 22785383 DOI: 10.1097/Fbp.0B013E3283564Dbb  0.362
2012 Negus SS, Morrissey EM, Folk JE, Rice KC. Interaction between Mu and Delta Opioid Receptor Agonists in an Assay of Capsaicin-Induced Thermal Allodynia in Rhesus Monkeys. Pain Research and Treatment. 2012: 867067. PMID 22666579 DOI: 10.1155/2012/867067  0.405
2012 Serafine KM, Briscione MA, Rice KC, Riley AL. Dopamine mediates cocaine-induced conditioned taste aversions as demonstrated with cross-drug preexposure to GBR 12909. Pharmacology, Biochemistry, and Behavior. 102: 269-74. PMID 22579912 DOI: 10.1016/J.Pbb.2012.04.012  0.322
2012 Lewis SS, Loram LC, Hutchinson MR, Li CM, Zhang Y, Maier SF, Huang Y, Rice KC, Watkins LR. (+)-naloxone, an opioid-inactive toll-like receptor 4 signaling inhibitor, reverses multiple models of chronic neuropathic pain in rats. The Journal of Pain : Official Journal of the American Pain Society. 13: 498-506. PMID 22520687 DOI: 10.1016/J.Jpain.2012.02.005  0.535
2012 Sawyer EK, Mun J, Nye JA, Kimmel HL, Voll RJ, Stehouwer JS, Rice KC, Goodman MM, Howell LL. Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1816-24. PMID 22434223 DOI: 10.1038/Npp.2012.29  0.319
2012 Negus SS, Rosenberg MB, Altarifi AA, O'Connell RH, Folk JE, Rice KC. Effects of the delta opioid receptor agonist SNC80 on pain-related depression of intracranial self-stimulation (ICSS) in rats Journal of Pain. 13: 317-327. PMID 22424913 DOI: 10.1016/J.Jpain.2011.12.003  0.316
2012 Iyer MR, Lee YS, Deschamps JR, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 44. Synthesis of an N-substituted 4-hydroxy-5-(3-hydroxyphenyl)morphan with high affinity and selective μ-antagonist activity. European Journal of Medicinal Chemistry. 50: 44-54. PMID 22341895 DOI: 10.1016/J.Ejmech.2012.01.025  0.386
2012 Koek W, France CP, Cheng K, Rice KC. Effects of the GABAB receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons. The Journal of Pharmacology and Experimental Therapeutics. 341: 369-76. PMID 22319197 DOI: 10.1124/Jpet.111.190975  0.308
2012 Murnane KS, Kimmel HL, Rice KC, Howell LL. The neuropharmacology of prolactin secretion elicited by 3,4-methylenedioxymethamphetamine ("ecstasy"): a concurrent microdialysis and plasma analysis study. Hormones and Behavior. 61: 181-90. PMID 22197270 DOI: 10.1016/J.Yhbeh.2011.10.012  0.308
2012 Kimura T, Yeliseev AA, Vukoti K, Rhodes SD, Cheng K, Rice KC, Gawrisch K. Recombinant cannabinoid type 2 receptor in liposome model activates g protein in response to anionic lipid constituents. The Journal of Biological Chemistry. 287: 4076-87. PMID 22134924 DOI: 10.1074/Jbc.M111.268425  0.301
2012 Negus SS, O'Connell R, Morrissey E, Cheng K, Rice KC. Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats Journal of Pharmacology and Experimental Therapeutics. 340: 501-509. PMID 22128346 DOI: 10.1124/Jpet.111.186783  0.4
2012 Wu Y, Lousberg EL, Moldenhauer LM, Hayball JD, Coller JK, Rice KC, Watkins LR, Somogyi AA, Hutchinson MR. Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice. British Journal of Pharmacology. 165: 1319-29. PMID 21955045 DOI: 10.1111/J.1476-5381.2011.01572.X  0.507
2012 Hensler JG, Advani T, Burke TF, Cheng K, Rice KC, Koek W. GABAB receptor-positive modulators: brain region-dependent effects. The Journal of Pharmacology and Experimental Therapeutics. 340: 19-26. PMID 21954301 DOI: 10.1124/Jpet.111.186577  0.317
2011 Hutchinson MR, Shavit Y, Grace PM, Rice KC, Maier SF, Watkins LR. Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacological Reviews. 63: 772-810. PMID 21752874 DOI: 10.1124/Pr.110.004135  0.569
2011 Koffarnus MN, Newman AH, Grundt P, Rice KC, Woods JH. Effects of selective dopaminergic compounds on a delay-discounting task. Behavioural Pharmacology. 22: 300-11. PMID 21694584 DOI: 10.1097/Fbp.0B013E3283473Bcb  0.556
2011 Li F, Folk JE, Cheng K, Kurimura M, Deck JA, Deschamps JR, Rothman RB, Dersch CM, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 43. Synthesis of the ortho-a and para-a, and improved synthesis and optical resolution of the ortho-b and para-b oxide-bridged phenylmorphans: compounds with moderate to low opioid-receptor affinity. Bioorganic & Medicinal Chemistry. 19: 4330-7. PMID 21684752 DOI: 10.1016/J.Bmc.2011.05.035  0.395
2011 Kim JH, Deschamps JR, Rothman RB, Dersch CM, Folk JE, Cheng K, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. Part 42: Synthesis and in vitro pharmacological characterization of the N-methyl and N-phenethyl analogues of the racemic ortho-c and para-c oxide-bridged phenylmorphans Bioorganic and Medicinal Chemistry. 19: 3434-3443. PMID 21570305 DOI: 10.1016/J.Bmc.2011.04.028  0.345
2011 Anastasio NC, Stoffel EC, Fox RG, Bubar MJ, Rice KC, Moeller FG, Cunningham KA. Serotonin (5-hydroxytryptamine) 5-HT(2A) receptor: association with inherent and cocaine-evoked behavioral disinhibition in rats. Behavioural Pharmacology. 22: 248-61. PMID 21499079 DOI: 10.1097/Fbp.0B013E328345F90D  0.302
2011 Xiong W, Cheng K, Cui T, Godlewski G, Rice KC, Xu Y, Zhang L. Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nature Chemical Biology. 7: 296-303. PMID 21460829 DOI: 10.1038/Nchembio.552  0.375
2011 Banks ML, Roma PG, Folk JE, Rice KC, Negus SS. Effects of the delta-opioid agonist SNC80 on the abuse liability of methadone in rhesus monkeys: a behavioral economic analysis. Psychopharmacology. 216: 431-9. PMID 21369752 DOI: 10.1007/S00213-011-2235-2  0.398
2011 Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 1207-18. PMID 21346735 DOI: 10.1038/Npp.2011.5  0.352
2011 Schank JR, Pickens CL, Rowe KE, Cheng K, Thorsell A, Rice KC, Shaham Y, Heilig M. Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429. Psychopharmacology. 218: 111-9. PMID 21340476 DOI: 10.1007/S00213-011-2201-Z  0.337
2011 Jagoda EM, Lang L, Mccullough K, Contoreggi C, Kim BM, Ma Y, Rice KC, Szajek LP, Eckelman WC, Kiesewetter DO. [76Br]BMK-152, a nonpeptide analogue, with high affinity and low nonspecific binding for the corticotropin-releasing factor type 1 receptor Synapse. 65: 910-918. PMID 21308801 DOI: 10.1002/Syn.20919  0.363
2011 Cheng K, Lee YS, Rothman RB, Dersch CM, Bittman RW, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 41. Unusual inverse μ-agonists and potent μ-opioid antagonists by modification of the N-substituent in enantiomeric 5-(3-hydroxyphenyl)morphans Journal of Medicinal Chemistry. 54: 957-969. PMID 21247164 DOI: 10.1021/Jm1011676  0.403
2011 Li JX, Koek W, Rice KC, France CP. Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 940-9. PMID 21209613 DOI: 10.1038/Npp.2010.232  0.374
2011 Li JX, Crocker C, Koek W, Rice KC, France CP. Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies. Psychopharmacology. 213: 489-97. PMID 21174080 DOI: 10.1007/S00213-010-2136-9  0.355
2011 Kimura T, Yeliseev A, Mihailescu M, Cheng K, Rice KC, Gawrisch K. Solid-State NMR Study of Ligand Binding to Human Peripheral Cannabinoid Receptor CB2 Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.3202  0.316
2011 Watkins L, Northcutt A, Loram L, Lewis S, Hutchinson M, Rice K, Maier S. 210. Rethinking CNS innate immune responses: Sex, pain and drugs of abuse Brain, Behavior, and Immunity. 25: S239. DOI: 10.1016/J.Bbi.2011.07.213  0.474
2011 Hutchinson M, Wu Y, Jaehne E, Liu L, Diener K, Hayball J, Rice K, Watkins L, Somogyi A. 97. Contributions of innate immune signaling to opioid & alcohol responses Brain, Behavior, and Immunity. 25: S206-S207. DOI: 10.1016/J.Bbi.2011.07.100  0.504
2011 Northcutt A, Stregola C, Bland S, Amat J, Hutchinson M, Miles N, Rosezke R, Loeffler M, Maier S, Rice K, Watkins L. Novel toll like receptor 4 (TLR4) involvement in drug reward Brain Behavior and Immunity. 25. DOI: 10.1016/J.Bbi.2011.07.040  0.535
2011 Micioni Di B M, Cifani C, Rice K, Ciccocioppo R, Massi M. Effect of the CRF-1 receptor antagonist R121919 on binge eating Appetite. 57: S30. DOI: 10.1016/J.Appet.2011.05.230  0.34
2010 Fantegrossi WE, Simoneau J, Cohen MS, Zimmerman SM, Henson CM, Rice KC, Woods JH. Interaction of 5-HT2A and 5-HT2C receptors in R(-)-2,5-dimethoxy-4-iodoamphetamine-elicited head twitch behavior in mice. The Journal of Pharmacology and Experimental Therapeutics. 335: 728-34. PMID 20858706 DOI: 10.1124/Jpet.110.172247  0.632
2010 Banks ML, Folk JE, Rice KC, Negus SS. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacology, Biochemistry, and Behavior. 97: 205-12. PMID 20678514 DOI: 10.1016/J.Pbb.2010.07.019  0.418
2010 Banks ML, Rice KC, Negus SS. Antinociceptive interactions between Mu-opioid receptor agonists and the serotonin uptake inhibitor clomipramine in rhesus monkeys: role of Mu agonist efficacy. The Journal of Pharmacology and Experimental Therapeutics. 335: 497-505. PMID 20675432 DOI: 10.1124/Jpet.110.169276  0.419
2010 Koek W, France CP, Cheng K, Rice KC. GABAB receptor-positive modulators: enhancement of GABAB receptor agonist effects in vivo. The Journal of Pharmacology and Experimental Therapeutics. 335: 163-71. PMID 20628000 DOI: 10.1124/Jpet.110.171116  0.334
2010 Hutchinson MR, Loram LC, Zhang Y, Shridhar M, Rezvani N, Berkelhammer D, Phipps S, Foster PS, Landgraf K, Falke JJ, Rice KC, Maier SF, Yin H, Watkins LR. Evidence that tricyclic small molecules may possess toll-like receptor and myeloid differentiation protein 2 activity. Neuroscience. 168: 551-63. PMID 20381591 DOI: 10.1016/J.Neuroscience.2010.03.067  0.546
2010 Hutchinson MR, Lewis SS, Coats BD, Rezvani N, Zhang Y, Wieseler JL, Somogyi AA, Yin H, Maier SF, Rice KC, Watkins LR. Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences. Neuroscience. 167: 880-93. PMID 20178837 DOI: 10.1016/J.Neuroscience.2010.02.011  0.587
2010 Negus SS, Morrissey EM, Rosenberg M, Cheng K, Rice KC. Effects of kappa opioids in an assay of pain-depressed intracranial self-stimulation in rats Psychopharmacology. 209: 149-159. PMID 20101391 DOI: 10.1007/S00213-009-1770-6  0.338
2010 Negus SS, Banks ML, Folk JE, Rice KC. Modulation of delta opioid agonist-induced antinociception by repeated morphine pretreatment in rhesus monkeys. Life Sciences. 86: 385-92. PMID 20096291 DOI: 10.1016/J.Lfs.2010.01.006  0.401
2010 Li JX, Koek W, Rice KC, France CP. Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 333: 244-52. PMID 20053932 DOI: 10.1124/Jpet.109.163451  0.374
2010 Iyer MR, Lee YS, Deschamps JR, Rothman RB, Dersch CM, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 40. N-substituted cis-4a-ethyl-1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-8-ols. Bioorganic & Medicinal Chemistry. 18: 91-9. PMID 20005115 DOI: 10.1016/J.Bmc.2009.11.022  0.315
2010 Sally EJ, Xu H, Dersch CM, Hsin LW, Chang LT, Prisinzano TE, Simpson DS, Giuvelis D, Rice KC, Jacobson AE, Cheng K, Bilsky EJ, Rothman RB. Identification of a novel "almost neutral" micro-opioid receptor antagonist in CHO cells expressing the cloned human mu-opioid receptor. Synapse (New York, N.Y.). 64: 280-8. PMID 19953652 DOI: 10.1002/Syn.20723  0.6
2010 Lewis SS, Hutchinson MR, Rezvani N, Loram LC, Zhang Y, Maier SF, Rice KC, Watkins LR. Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta. Neuroscience. 165: 569-83. PMID 19833175 DOI: 10.1016/J.Neuroscience.2009.10.011  0.571
2010 Hutchinson MR, Zhang Y, Shridhar M, Evans JH, Buchanan MM, Zhao TX, Slivka PF, Coats BD, Rezvani N, Wieseler J, Hughes TS, Landgraf KE, Chan S, Fong S, Phipps S, ... ... Rice KC, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain, Behavior, and Immunity. 24: 83-95. PMID 19679181 DOI: 10.1016/J.Bbi.2009.08.004  0.581
2010 Hutchinson M, Wu Y, Liu L, Phipps S, Rice K, Coller J, Watkins L, Somogyi A. Opioid and alcohol action: The role of brain and spinal cord innate immune signalling Brain, Behavior, and Immunity. 24: S19. DOI: 10.1016/J.Bbi.2010.07.060  0.496
2009 Hutchinson MR, Ramos KM, Loram LC, Wieseler J, Sholar PW, Kearney JJ, Lewis MT, Crysdale NY, Zhang Y, Harrison JA, Maier SF, Rice KC, Watkins LR. Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats. Neuroscience. 164: 1821-32. PMID 19788917 DOI: 10.1016/J.Neuroscience.2009.09.046  0.529
2009 Watkins LR, Hutchinson MR, Rice KC, Maier SF. The "toll" of opioid-induced glial activation: improving the clinical efficacy of opioids by targeting glia. Trends in Pharmacological Sciences. 30: 581-91. PMID 19762094 DOI: 10.1016/J.Tips.2009.08.002  0.569
2009 Li JX, Unzeitig A, Javors MA, Rice KC, Koek W, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 671-9. PMID 19687292 DOI: 10.1124/Jpet.109.157560  0.331
2009 Kreibich AS, Briand L, Cleck JN, Ecke L, Rice KC, Blendy JA. Stress-induced potentiation of cocaine reward: a role for CRF R1 and CREB. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 2609-17. PMID 19675537 DOI: 10.1038/Npp.2009.91  0.325
2009 Zhang Y, Lee YS, Rothman RB, Dersch CM, Deschamps JR, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 39. Enantiomeric n-substituted benzofuro[2,3-c]pyridin-6-ols: synthesis and topological relationship to oxide-bridged phenylmorphans Journal of Medicinal Chemistry. 52: 7570-7579. PMID 19627147 DOI: 10.1021/Jm9004225  0.345
2009 Davis CM, Rice KC, Riley AL. Opiate-agonist induced taste aversion learning in the Fischer 344 and Lewis inbred rat strains: evidence for differential mu opioid receptor activation. Pharmacology, Biochemistry, and Behavior. 93: 397-405. PMID 19508878 DOI: 10.1016/J.Pbb.2009.06.001  0.375
2009 Francesconi W, Berton F, Repunte-Canonigo V, Hagihara K, Thurbon D, Lekic D, Specio SE, Greenwell TN, Chen SA, Rice KC, Richardson HN, O'Dell LE, Zorrilla EP, Morales M, Koob GF, et al. Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5389-401. PMID 19403807 DOI: 10.1523/Jneurosci.5129-08.2009  0.312
2009 Jones JD, Hall FS, Uhl GR, Rice K, Riley AL. Differential involvement of the norepinephrine, serotonin and dopamine reuptake transporter proteins in cocaine-induced taste aversion. Pharmacology, Biochemistry, and Behavior. 93: 75-81. PMID 19376154 DOI: 10.1016/J.Pbb.2009.04.009  0.313
2009 Nic Dhonnchadha BA, Fox RG, Stutz SJ, Rice KC, Cunningham KA. Blockade of the serotonin 5-HT2A receptor suppresses cue-evoked reinstatement of cocaine-seeking behavior in a rat self-administration model. Behavioral Neuroscience. 123: 382-96. PMID 19331461 DOI: 10.1037/A0014592  0.338
2009 Collins GT, Truccone A, Haji-Abdi F, Newman AH, Grundt P, Rice KC, Husbands SM, Greedy BM, Enguehard-Gueiffier C, Gueiffier A, Chen J, Wang S, Katz JL, Grandy DK, Sunahara RK, et al. Proerectile effects of dopamine D2-like agonists are mediated by the D3 receptor in rats and mice. The Journal of Pharmacology and Experimental Therapeutics. 329: 210-7. PMID 19136638 DOI: 10.1124/Jpet.108.144048  0.526
2009 Do Carmo GP, Folk JE, Rice KC, Chartoff E, Carlezon WA, Negus SS. The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats. European Journal of Pharmacology. 604: 58-65. PMID 19133255 DOI: 10.1016/J.Ejphar.2008.12.021  0.396
2009 Li JX, Rice KC, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses. The Journal of Pharmacology and Experimental Therapeutics. 328: 976-81. PMID 19098164 DOI: 10.1124/Jpet.108.145458  0.352
2009 Negus SS, Bear AE, Folk JE, Rice KC. Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys. European Journal of Pharmacology. 602: 92-100. PMID 19027735 DOI: 10.1016/J.Ejphar.2008.11.004  0.393
2009 May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, Young R, Li JX, Rice KC, France CP. Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. Pharmacology, Biochemistry, and Behavior. 91: 307-14. PMID 18718483 DOI: 10.1016/J.Pbb.2008.07.015  0.513
2009 Negus SS, Rice KC. Mechanisms of withdrawal-associated increases in heroin self-administration: Pharmacologic modulation of heroin vs food choice in heroin-dependent rhesus monkeys Neuropsychopharmacology. 34: 899-911. PMID 18704098 DOI: 10.1038/Npp.2008.127  0.384
2009 Davis CM, Stevenson GW, Cañadas F, Ullrich T, Rice KC, Riley AL. Discriminative stimulus properties of naloxone in Long-Evans rats: assessment with the conditioned taste aversion baseline of drug discrimination learning. Psychopharmacology. 203: 421-9. PMID 18594795 DOI: 10.1007/S00213-008-1233-5  0.424
2009 Lang L, Ma Y, Kim BM, Jagoda EM, Rice KC, Szajek LP, Contoreggi C, Gold PW, Chrousos GP, Eckelman WC, Kiesewettera DO. [76Br]BMK-I-152, a non-peptide analogue for PET imaging of corticotropin-releasing hormone type 1 receptor (CRHR1) Journal of Labelled Compounds and Radiopharmaceuticals. 52: 394-400. DOI: 10.1002/Jlcr.1616  0.304
2008 Kurimura M, Liu H, Sulima A, Hashimoto A, Przybyl AK, Ohshima E, Kodato S, Deschamps JR, Dersch CM, Rothman RB, Yong SL, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 37.1 Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers Journal of Medicinal Chemistry. 51: 7866-7881. PMID 19053757 DOI: 10.1021/Jm800913D  0.379
2008 Zezula J, Singer L, Przybył AK, Hashimoto A, Dersch CM, Rothman RB, Deschamps J, Lee YS, Jacobson AE, Rice KC. Synthesis and pharmacological effects of the enantiomers of the N-phenethyl analogues of the ortho and para e- and f-oxide-bridged phenylmorphans. Organic & Biomolecular Chemistry. 6: 2868-83. PMID 18688479 DOI: 10.1039/B803433H  0.373
2008 Hutchinson MR, Zhang Y, Brown K, Coats BD, Shridhar M, Sholar PW, Patel SJ, Crysdale NY, Harrison JA, Maier SF, Rice KC, Watkins LR. Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4). The European Journal of Neuroscience. 28: 20-9. PMID 18662331 DOI: 10.1111/J.1460-9568.2008.06321.X  0.544
2008 Do Carmo GP, Polt R, Bilsky EJ, Rice KC, Negus SS. Behavioral pharmacology of the mu/delta opioid glycopeptide MMP2200 in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 326: 939-48. PMID 18511649 DOI: 10.1124/Jpet.108.138180  0.371
2008 Rutherford JM, Wang J, Xu H, Dersch CM, Partilla JS, Rice KC, Rothman RB. Evidence for a mu-delta opioid receptor complex in CHO cells co-expressing mu and delta opioid peptide receptors. Peptides. 29: 1424-31. PMID 18472184 DOI: 10.1016/J.Peptides.2008.03.019  0.392
2008 Hsin LW, Chang LT, Rothman RB, Dersch CM, Jacobson AE, Rice KC. Design and synthesis of 2- and 3-substituted-3-phenylpropyl analogs of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine: Role of amino, fluoro, hydroxyl, methoxyl, methyl, methylene, and oxo substituents on affinity for the dopamine and serotonin transporters Journal of Medicinal Chemistry. 51: 2795-2806. PMID 18393401 DOI: 10.1021/Jm701270N  0.341
2008 Pascoe JE, Williams KL, Mukhopadhyay P, Rice KC, Woods JH, Ko MC. Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys. Psychoneuroendocrinology. 33: 478-86. PMID 18325678 DOI: 10.1016/J.Psyneuen.2008.01.006  0.419
2008 Li JX, Rice KC, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 324: 827-33. PMID 17993605 DOI: 10.1124/Jpet.107.130625  0.382
2008 Jutkiewicz EM, Baladi MG, Folk JE, Rice KC, Woods JH. The delta-opioid receptor agonist SNC80 [(+)-4-[alpha(R)-alpha-[(2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl]-(3-methoxybenzyl)-N,N-diethylbenzamide] synergistically enhances the locomotor-activating effects of some psychomotor stimulants, but not direct dopamine agonists, in rats. The Journal of Pharmacology and Experimental Therapeutics. 324: 714-24. PMID 17986650 DOI: 10.1124/Jpet.107.123844  0.425
2008 Reissig CJ, Eckler JR, Rabin RA, Rice KC, Winter JC. The stimulus effects of 8-OH-DPAT: evidence for a 5-HT2A receptor-mediated component. Pharmacology, Biochemistry, and Behavior. 88: 312-7. PMID 17936346 DOI: 10.1016/J.Pbb.2007.09.011  0.38
2008 Fantegrossi WE, Reissig CJ, Katz EB, Yarosh HL, Rice KC, Winter JC. Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): Possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents Pharmacology Biochemistry and Behavior. 88: 358-365. PMID 17905422 DOI: 10.1016/J.Pbb.2007.09.007  0.654
2008 France CP, Unzeitig A, Javors MA, Rice KC, Li J. IS THERE BEHAVIORAL EVIDENCE FOR CONSTITUTIVE ACTIVITY AT 5-HT2ARECEPTORS? Alcoholism: Clinical and Experimental Research. 32: 367A-367A. DOI: 10.1111/J.1530-0277.2008.00689_2.X  0.389
2007 Hutchinson MR, Bland ST, Johnson KW, Rice KC, Maier SF, Watkins LR. Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward. Thescientificworldjournal. 7: 98-111. PMID 17982582 DOI: 10.1100/Tsw.2007.230  0.574
2007 Zhao Y, Valdez GR, Fekete EM, Rivier JE, Vale WW, Rice KC, Weiss F, Zorrilla EP. Subtype-selective corticotropin-releasing factor receptor agonists exert contrasting, but not opposite, effects on anxiety-related behavior in rats. The Journal of Pharmacology and Experimental Therapeutics. 323: 846-54. PMID 17855476 DOI: 10.1124/Jpet.107.123208  0.327
2007 Winter JC, Rice KC, Amorosi DJ, Rabin RA. Psilocybin-induced stimulus control in the rat Pharmacology Biochemistry and Behavior. 87: 472-480. PMID 17688928 DOI: 10.1016/J.Pbb.2007.06.003  0.345
2007 Hiebel AC, Lee YS, Bilsky E, Giuvelis D, Deschamps JR, Parrish DA, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Partilla JS, Rothman RB, Cheng K, Jacobson AE, ... Rice KC, et al. Probes for narcotic receptor mediated phenomena. 34. Synthesis and structure-activity relationships of a potent mu-agonist delta-antagonist and an exceedingly potent antinociceptive in the enantiomeric C9-substituted 5-(3-hydroxyphenyl)-N-phenylethylmorphan series. Journal of Medicinal Chemistry. 50: 3765-76. PMID 17625813 DOI: 10.1021/Jm061325E  0.682
2007 Li JX, Rice KC, France CP. Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. Behavioural Pharmacology. 18: 283-8. PMID 17551320 DOI: 10.1097/Fbp.0B013E3281F19Ca0  0.397
2007 Kino T, Rice KC, Chrousos GP. The PPARδ agonist GW501516 suppresses interleukin-6-mediated hepatocyte acute phase reaction via STAT3 inhibition European Journal of Clinical Investigation. 37: 425-433. PMID 17461989 DOI: 10.1111/J.1365-2362.2007.01796.X  0.302
2007 Wang B, You ZB, Rice KC, Wise RA. Stress-induced relapse to cocaine seeking: roles for the CRF(2) receptor and CRF-binding protein in the ventral tegmental area of the rat. Psychopharmacology. 193: 283-94. PMID 17437087 DOI: 10.1007/S00213-007-0782-3  0.356
2007 Cheng K, Kim IJ, Lee MJ, Adah SA, Raymond TJ, Bilsky EJ, Aceto MD, May EL, Harris LS, Coop A, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Opioid ligands with mixed properties from substituted enantiomeric N-phenethyl-5-phenylmorphans. Synthesis of a micro-agonist delta-antagonist and delta-inverse agonists. Organic & Biomolecular Chemistry. 5: 1177-90. PMID 17406716 DOI: 10.1039/B618875C  0.724
2007 Collins GT, Newman AH, Grundt P, Rice KC, Husbands SM, Chauvignac C, Chen J, Wang S, Woods JH. Yawning and hypothermia in rats: effects of dopamine D3 and D2 agonists and antagonists. Psychopharmacology. 193: 159-70. PMID 17393143 DOI: 10.1007/S00213-007-0766-3  0.52
2007 Gilbert KM, Boos TL, Dersch CM, Greiner E, Jacobson AE, Lewis D, Matecka D, Prisinzano TE, Zhang Y, Rothman RB, Rice KC, Venanzi CA. DAT/SERT selectivity of flexible GBR 12909 analogs modeled using 3D-QSAR methods. Bioorganic & Medicinal Chemistry. 15: 1146-59. PMID 17127069 DOI: 10.1016/J.Bmc.2006.09.070  0.552
2007 Sulima A, Folk J, Jacobson AE, Rice KC. A new approach to the synthesis of the nonpeptide NOP receptor antagonist J-113397 Synthesis. 1547-1553. DOI: 10.1055/S-2007-966037  0.327
2006 Mello NK, Negus SS, Rice KC, Mendelson JH. Effects of the CRF1 antagonist antalarmin on cocaine self-administration and discrimination in rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 85: 744-51. PMID 17182090 DOI: 10.1016/J.Pbb.2006.11.008  0.309
2006 Danielsson I, Gasior M, Stevenson GW, Folk JE, Rice KC, Negus SS. Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. Pharmacology, Biochemistry, and Behavior. 85: 428-34. PMID 17112570 DOI: 10.1016/J.Pbb.2006.09.012  0.339
2006 Do Carmo GP, Mello NK, Rice KC, Folk JE, Negus SS. Effects of the selective delta opioid agonist SNC80 on cocaine- and food-maintained responding in rhesus monkeys. European Journal of Pharmacology. 547: 92-100. PMID 16934797 DOI: 10.1016/J.Ejphar.2006.06.075  0.336
2006 Fox MA, Stevenson GW, Rice KC, Riley AL. Naloxone, not proglumide or MK-801, alters effects of morphine preexposure on morphine-induced taste aversions. Pharmacology, Biochemistry, and Behavior. 84: 169-77. PMID 16777201 DOI: 10.1016/J.Pbb.2006.05.003  0.371
2006 Wood SK, Verhoeven RE, Savit AZ, Rice KC, Fischbach PS, Woods JH. Facilitation of cardiac vagal activity by CRF-R1 antagonists during swim stress in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 31: 2580-90. PMID 16710322 DOI: 10.1038/Sj.Npp.1301085  0.34
2006 Milman A, Weizman R, Rigai T, Rice KC, Pick CG. Behavioral effects of opioid subtypes compared with benzodiazepines in the staircase paradigm. Behavioural Brain Research. 170: 141-7. PMID 16574254 DOI: 10.1016/J.Bbr.2006.02.017  0.431
2006 Boos TL, Greiner E, Calhoun WJ, Prisinzano TE, Nightingale B, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Structure-activity relationships of substituted N-benzyl piperidines in the GBR series: Synthesis of 4-(2-(bis(4-fluorophenyl)methoxy)ethyl)-1-(2-trifluoromethylbenzyl)piperidine, an allosteric modulator of the serotonin transporter. Bioorganic & Medicinal Chemistry. 14: 3967-73. PMID 16563775 DOI: 10.1016/J.Bmc.2006.01.065  0.583
2006 Jutkiewicz EM, Baladi MG, Folk JE, Rice KC, Woods JH. The convulsive and electroencephalographic changes produced by nonpeptidic delta-opioid agonists in rats: comparison with pentylenetetrazol. The Journal of Pharmacology and Experimental Therapeutics. 317: 1337-48. PMID 16537798 DOI: 10.1124/Jpet.105.095810  0.404
2006 Zhang H, Torregrossa MM, Jutkiewicz EM, Shi YG, Rice KC, Woods JH, Watson SJ, Ko MC. Endogenous opioids upregulate brain-derived neurotrophic factor mRNA through delta- and micro-opioid receptors independent of antidepressant-like effects. The European Journal of Neuroscience. 23: 984-94. PMID 16519663 DOI: 10.1111/J.1460-9568.2006.04621.X  0.387
2006 Greiner E, Boos TL, Prisinzano TE, De Martino MG, Zeglis B, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Design and synthesis of promiscuous high-affinity monoamine transporter ligands: unraveling transporter selectivity. Journal of Medicinal Chemistry. 49: 1766-72. PMID 16509591 DOI: 10.1021/Jm050766F  0.568
2006 Fantegrossi WE, Harrington AW, Kiessel CL, Eckler JR, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH. Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Pharmacology, Biochemistry, and Behavior. 83: 122-9. PMID 16460788 DOI: 10.1016/J.Pbb.2005.12.015  0.726
2006 Jutkiewicz EM, Torregrossa MM, Sobczyk-Kojiro K, Mosberg HI, Folk JE, Rice KC, Watson SJ, Woods JH. Behavioral and neurobiological effects of the enkephalinase inhibitor RB101 relative to its antidepressant effects. European Journal of Pharmacology. 531: 151-9. PMID 16442521 DOI: 10.1016/J.Ejphar.2005.12.002  0.432
2006 Taylor JL, Bishop C, Ullrich T, Rice KC, Walker PD. Serotonin 2A receptor antagonist treatment reduces dopamine D1 receptor-mediated rotational behavior but not L-DOPA-induced abnormal involuntary movements in the unilateral dopamine-depleted rat. Neuropharmacology. 50: 761-8. PMID 16434065 DOI: 10.1016/J.Neuropharm.2005.12.004  0.339
2006 Gardell LR, King T, Ossipov MH, Rice KC, Lai J, Vanderah TW, Porreca F. Opioid receptor-mediated hyperalgesia and antinociceptive tolerance induced by sustained opiate delivery. Neuroscience Letters. 396: 44-9. PMID 16343768 DOI: 10.1016/J.Neulet.2005.11.009  0.383
2006 Hiebel AC, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Synthesis of [3H]-labelled 4-[ethyl[2,5,6-trimethyl-7-(2,4,6- trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amino]-2,3-[3H]-butan-1- ol: A high affinity radioligand for the corticotropin-releasing hormone type 1 receptor Journal of Labelled Compounds and Radiopharmaceuticals. 49: 635-640. DOI: 10.1002/Jlcr.1082  0.339
2006 Zezula J, Wang HYJ, Woods AS, Wise RA, Jacobson AE, Rice KC. The high specific activity tritium labeling of the ganglion-blocking nicotinic antagonist chlorisondamine Journal of Labelled Compounds and Radiopharmaceuticals. 49: 471-478. DOI: 10.1002/Jlcr.1069  0.316
2005 Freeman KB, Rice KC, Riley AL. Assessment of monoamine transporter inhibition in the mediation of cocaine-induced conditioned taste aversion. Pharmacology, Biochemistry, and Behavior. 82: 583-9. PMID 16337262 DOI: 10.1016/J.Pbb.2005.10.014  0.313
2005 Torregrossa MM, Folk JE, Rice KC, Watson SJ, Woods JH. Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats. Psychopharmacology. 183: 31-40. PMID 16220339 DOI: 10.1007/S00213-005-0113-5  0.322
2005 Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats. Psychopharmacology. 182: 588-96. PMID 16163520 DOI: 10.1007/S00213-005-0138-9  0.413
2005 Jutkiewicz EM, Kaminsky ST, Rice KC, Traynor JR, Woods JH. Differential behavioral tolerance to the delta-opioid agonist SNC80 ([(+)-4-[(alphaR)-alpha-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide) in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 315: 414-22. PMID 16014751 DOI: 10.1124/Jpet.105.088831  0.434
2005 Sulima A, Prisinzano TE, Spande T, Deschamps JR, Whittaker N, Hochberg Z, Jacobson AE, Rice KC. A concise method for the preparation of deuterium-labeled cortisone: synthesis of [6,7-2H]cortisone. Steroids. 70: 763-9. PMID 16005918 DOI: 10.1016/J.Steroids.2005.04.006  0.531
2005 Fantegrossi WE, Harrington AW, Eckler JR, Arshad S, Rabin RA, Winter JC, Coop A, Rice KC, Woods JH. Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats. Psychopharmacology. 181: 496-503. PMID 15983786 DOI: 10.1007/S00213-005-0009-4  0.721
2005 Winter JC, Eckler JR, Rice KC, Rabin RA. Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram. Pharmacology, Biochemistry, and Behavior. 81: 694-700. PMID 15970314 DOI: 10.1016/J.Pbb.2005.03.022  0.349
2005 Wu H, Thatcher LN, Bernard D, Parrish DA, Deschamps JR, Rice KC, MacKerell AD, Coop A. Position of coordination of the lithium ion determines the regioselectivity of demethylations of 3,4-dimethoxymorphinans with L-selectride. Organic Letters. 7: 2531-4. PMID 15957883 DOI: 10.1021/Ol050433C  0.527
2005 Caballero-Hernández D, Weber RJ, Hicks ME, Tamez-Guerra R, Rodríguez-Padilla C, Tamez-Guerra P, Rice KC, Ananthan S, Gomez-Flores R. Potentiation of rat lymphocyte proliferation by novel non-peptidic synthetic opioids. International Immunopharmacology. 5: 1271-8. PMID 15914331 DOI: 10.1016/J.Intimp.2005.03.009  0.378
2005 Pick CG, Chernes Y, Rigai T, Rice KC, Schreiber S. The antinociceptive effect of zolpidem and zopiclone in mice Pharmacology Biochemistry and Behavior. 81: 417-423. PMID 15913749 DOI: 10.1016/J.Pbb.2005.02.013  0.378
2005 Nightingale B, Dersch CM, Boos TL, Greiner E, Calhoun WJ, Jacobson AE, Rice KC, Rothman RB. Studies of the biogenic amine transporters. XI. Identification of a 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR12909) analog that allosterically modulates the serotonin transporter. The Journal of Pharmacology and Experimental Therapeutics. 314: 906-15. PMID 15860577 DOI: 10.1124/Jpet.105.084376  0.311
2005 Stoffel EC, Ulibarri CM, Folk JE, Rice KC, Craft RM. Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats. The Journal of Pain : Official Journal of the American Pain Society. 6: 261-74. PMID 15820914 DOI: 10.1016/J.Jpain.2004.12.006  0.333
2005 Stevenson GW, Folk JE, Rice KC, Negus SS. Interactions between delta and mu opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice in rhesus monkeys: studies with SNC80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide] and heroin. The Journal of Pharmacology and Experimental Therapeutics. 314: 221-31. PMID 15792997 DOI: 10.1124/Jpet.104.082685  0.396
2005 Herin DV, Liu S, Ullrich T, Rice KC, Cunningham KA. Role of the serotonin 5-HT2A receptor in the hyperlocomotive and hyperthermic effects of (+)-3,4-methylenedioxymethamphetamine. Psychopharmacology. 178: 505-13. PMID 15765263 DOI: 10.1007/S00213-004-2030-4  0.334
2005 Jutkiewicz EM, Wood SK, Houshyar H, Hsin LW, Rice KC, Woods JH. The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats. Psychopharmacology. 180: 215-23. PMID 15696320 DOI: 10.1007/S00213-005-2164-Z  0.317
2005 Jiang JK, Thomas CJ, Neumann S, Lu X, Rice KC, Gershengorn MC. 1-(Phenyl)isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors. Bioorganic & Medicinal Chemistry Letters. 15: 733-6. PMID 15664847 DOI: 10.1016/J.Bmcl.2004.11.017  0.341
2005 Jutkiewicz EM, Walker NP, Folk JE, Rice KC, Portoghese PS, Woods JH, Traynor JR. Comparison of peptidic and nonpeptidic delta-opioid agonists on guanosine 5'-O-(3-[35S]thio)triphosphate ([35S]GTPgammaS) binding in brain slices from Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 312: 1314-20. PMID 15574687 DOI: 10.1124/Jpet.104.078741  0.4
2004 Hashimoto A, Przybyl AK, Linders JT, Kodato S, Tian X, Deschamps JR, George C, Flippen-Anderson JL, Jacobson AE, Rice KC. Probes for narcotic receptor-mediated phenomena. 33. Construction of a strained trans-5,6-ring system by displacement of a nitro-activated aromatic fluorine. synthesis of the penultimate oxide-bridged phenylmorphans. The Journal of Organic Chemistry. 69: 5322-7. PMID 15287777 DOI: 10.1021/Jo040159K  0.339
2004 Kim IJ, Dersch CM, Rothman RB, Jacobson AE, Rice KC. A critical structural determinant of opioid receptor interaction with phenolic 5-phenylmorphans. Bioorganic & Medicinal Chemistry. 12: 4543-4550. PMID 15265502 DOI: 10.1016/J.Bmc.2004.05.038  0.373
2004 Yu H, Kim IJ, Folk JE, Tian X, Rothman RB, Baumann MH, Dersch CM, Flippen-Anderson JL, Parrish D, Jacobson AE, Rice KC. Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters. Journal of Medicinal Chemistry. 47: 2624-34. PMID 15115403 DOI: 10.1021/Jm0305873  0.348
2004 Bishop C, Tessmer JL, Ullrich T, Rice KC, Walker PD. Serotonin 5-HT2A receptors underlie increased motor behaviors induced in dopamine-depleted rats by intrastriatal 5-HT2A/2C agonism. The Journal of Pharmacology and Experimental Therapeutics. 310: 687-94. PMID 15044557 DOI: 10.1124/Jpet.104.066365  0.328
2004 Broadbear JH, Winger G, Rivier JE, Rice KC, Woods JH. Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1112-21. PMID 14997174 DOI: 10.1038/Sj.Npp.1300410  0.339
2004 Lindsey KP, Wilcox KM, Votaw JR, Goodman MM, Plisson C, Carroll FI, Rice KC, Howell LL. Effects of dopamine transporter inhibitors on cocaine self-administration in rhesus monkeys: relationship to transporter occupancy determined by positron emission tomography neuroimaging. The Journal of Pharmacology and Experimental Therapeutics. 309: 959-69. PMID 14982963 DOI: 10.1124/Jpet.103.060293  0.316
2004 Fantegrossi WE, Kiessel CL, Leach PT, Van Martin C, Karabenick RL, Chen X, Ohizumi Y, Ullrich T, Rice KC, Woods JH. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology. 173: 270-7. PMID 14740148 DOI: 10.1007/S00213-003-1741-2  0.644
2004 Jutkiewicz EM, Eller EB, Folk JE, Rice KC, Traynor JR, Woods JH. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. The Journal of Pharmacology and Experimental Therapeutics. 309: 173-81. PMID 14722329 DOI: 10.1124/Jpet.103.061242  0.401
2004 Torregrossa MM, Isgor C, Folk JE, Rice KC, Watson SJ, Woods JH. The delta-opioid receptor agonist (+)BW373U86 regulates BDNF mRNA expression in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 649-59. PMID 14647482 DOI: 10.1038/Sj.Npp.1300345  0.355
2004 Thompson CM, Wojno H, Greiner E, May EL, Rice KC, Selley DE. Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors. The Journal of Pharmacology and Experimental Therapeutics. 308: 547-54. PMID 14600248 DOI: 10.1124/Jpet.103.058602  0.611
2004 Prisinzano T, Rice KC, Baumann MH, Rothman RB. Development of Neurochemical Normalization ("Agonist Substitution") Therapeutics for Stimulant Abuse: Focus on the Dopamine Uptake Inhibitor, GBR12909 Current Medicinal Chemistry - Central Nervous System Agents. 4: 47-59. DOI: 10.2174/1568015043477630  0.569
2004 Deschamps JR, Coop A, Parrish DA, Rice KC. 7β,14β-Epoxyhydrocodone-6,6-dimethoxy ketal: An unusual oxetane-containing opioid Acta Crystallographica Section E: Structure Reports Online. 60: o331-o333. DOI: 10.1107/S1600536804002077  0.544
2003 Jutkiewicz EM, Rice KC, Woods JH, Winsauer PJ. Effects of the delta-opioid receptor agonist SNC80 on learning relative to its antidepressant-like effects in rats. Behavioural Pharmacology. 14: 509-16. PMID 14557718 DOI: 10.1097/00008877-200311000-00003  0.357
2003 Stevenson GW, Folk JE, Linsenmayer DC, Rice KC, Negus SS. Opioid interactions in rhesus monkeys: effects of delta + mu and delta + kappa agonists on schedule-controlled responding and thermal nociception. The Journal of Pharmacology and Experimental Therapeutics. 307: 1054-64. PMID 14557380 DOI: 10.1124/Jpet.103.056515  0.427
2003 Kim IJ, Ullrich T, Janetka JW, Furness MS, Jacobson AE, Rothman RB, Dersch CM, Flippen-Anderson JL, George C, Rice KC. Diaryldimethylpiperazine ligands with μ- and δ-opioid receptor affinity: Synthesis of (+)-4-[(αR)-α -(4-allyl-(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl] -N-ethyl-N-phenylbenzamide and (-)-4-[(αR)-α -(2S,5S)-dimethylpiperazin-1-yl)-(3-hydroxyphenyl)methyl] -N-ethyl-N-phenylbenzamide Bioorganic and Medicinal Chemistry. 11: 4761-4768. PMID 14556791 DOI: 10.1016/S0968-0896(03)00496-6  0.676
2003 Rothman RB, Jayanthi S, Wang X, Dersch CM, Cadet JL, Prisinzano T, Rice KC, Baumann MH. High-dose fenfluramine administration decreases serotonin transporter binding, but not serotonin transporter protein levels, in rat forebrain. Synapse (New York, N.Y.). 50: 233-9. PMID 14515341 DOI: 10.1002/Syn.10266  0.561
2003 Jagoda E, Contoreggi C, Lee MJ, Kao CH, Szajek LP, Listwak S, Gold P, Chrousos G, Greiner E, Kim BM, Jacobson AE, Rice KC, Eckelman W. Autoradiographic visualization of corticotropin releasing hormone type 1 receptors with a nonpeptide ligand: synthesis of [(76)Br]MJL-1-109-2. Journal of Medicinal Chemistry. 46: 3559-62. PMID 12904058 DOI: 10.1021/Jm034077K  0.311
2003 Janetka JW, Furness MS, Zhang X, Coop A, Folk JE, Mattson MV, Jacobson AE, Rice KC. Enantioconvergent synthesis of (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine, an intermediate to δ-opioid receptor ligands Journal of Organic Chemistry. 68: 3976-3980. PMID 12737580 DOI: 10.1021/Jo0300385  0.745
2003 Williams KL, Ko MC, Rice KC, Woods JH. Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys. Psychoneuroendocrinology. 28: 513-28. PMID 12689609 DOI: 10.1016/S0306-4530(02)00037-9  0.403
2003 Greiner E, Prisinzano T, Johnson EM, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Structure-activity relationship studies of highly selective inhibitors of the dopamine transporter: N-benzylpiperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine. Journal of Medicinal Chemistry. 46: 1465-9. PMID 12672246 DOI: 10.1021/Jm020419V  0.569
2003 Varga EV, Rubenzik MK, Stropova D, Sugiyama M, Grife V, Hruby VJ, Rice KC, Roeske WR, Yamamura HI. Converging protein kinase pathways mediate adenylyl cyclase superactivation upon chronic delta-opioid agonist treatment. The Journal of Pharmacology and Experimental Therapeutics. 306: 109-15. PMID 12660310 DOI: 10.1124/Jpet.103.049643  0.363
2003 Lewis D, Zhang Y, Prisinzano T, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Further exploration of 1-[2-[Bis-(4-fluorophenyl)methoxy]ethyl]piperazine (GBR 12909): role of N-aromatic, N-heteroaromatic, and 3-oxygenated N-phenylpropyl substituents on affinity for the dopamine and serotonin transporter. Bioorganic & Medicinal Chemistry Letters. 13: 1385-9. PMID 12657288 DOI: 10.1016/S0960-894X(03)00108-2  0.576
2003 Hsin LW, Prisinzano T, Wilkerson CR, Dersch CM, Horel R, Jacobson AE, Rothman RB, Rice KC. Synthesis and dopamine transporter affinity of chiral 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(2-hydroxypropyl)piperazines as potential cocaine abuse therapeutic agents. Bioorganic & Medicinal Chemistry Letters. 13: 553-6. PMID 12565970 DOI: 10.1016/S0960-894X(02)00940-X  0.583
2003 Fantegrossi WE, Godlewski T, Karabenick RL, Stephens JM, Ullrich T, Rice KC, Woods JH. Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice. Psychopharmacology. 166: 202-11. PMID 12563544 DOI: 10.1007/S00213-002-1261-5  0.628
2003 Okura T, Varga EV, Hosohata Y, Navratilova E, Cowell SM, Rice K, Nagase H, Hruby VJ, Roeske WR, Yamamura HI. Agonist-specific down-regulation of the human delta-opioid receptor. European Journal of Pharmacology. 459: 9-16. PMID 12505529 DOI: 10.1016/S0014-2999(02)02823-6  0.415
2003 Prisinzano T, Hsin L, Folk JE, Flippen-Anderson JL, George C, Jacobson AE, Rice KC. A concise synthesis of (S)-(+)-1-(4-{2-[bis-(4-fluorophenyl)methoxy]-ethyl}piperazin-1-yl)-2-phenylpropan-2-ol dimaleate Tetrahedron: Asymmetry. 14: 3285-3289. DOI: 10.1016/J.Tetasy.2003.05.001  0.526
2003 Linders J, Mirsadeghi S, Flippen-Anderson J, George C, Jacobson A, Rice K. Probes for Narcotic Receptor Mediated Phenomena Helvetica Chimica Acta. 86: 484-493. DOI: 10.1002/Hlca.200390048  0.312
2002 Broadbear JH, Winger G, Rice KC, Woods JH. Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys. Psychopharmacology. 164: 268-76. PMID 12424550 DOI: 10.1007/S00213-002-1187-Y  0.316
2002 Negus SS, Bidlack JM, Mello NK, Furness MS, Rice KC, Brandt MR. Delta opioid antagonist effects of buprenorphine in rhesus monkeys. Behavioural Pharmacology. 13: 557-70. PMID 12409994 DOI: 10.1097/00008877-200211000-00005  0.44
2002 Broom DC, Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Behavioral effects of delta-opioid receptor agonists: potential antidepressants? Japanese Journal of Pharmacology. 90: 1-6. PMID 12396021 DOI: 10.1254/Jjp.90.1  0.407
2002 Broom DC, Nitsche JF, Pintar JE, Rice KC, Woods JH, Traynor JR. Comparison of receptor mechanisms and efficacy requirements for delta-agonist-induced convulsive activity and antinociception in mice. The Journal of Pharmacology and Experimental Therapeutics. 303: 723-9. PMID 12388657 DOI: 10.1124/Jpet.102.036525  0.437
2002 Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Convulsant activity of a non-peptidic delta-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats. Psychopharmacology. 164: 42-8. PMID 12373418 DOI: 10.1007/S00213-002-1179-Y  0.416
2002 Prisinzano T, Greiner E, Johnson EM, Dersch CM, Marcus J, Partilla JS, Rothman RB, Jacobson AE, Rice KC. Piperidine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909): high affinity ligands for the dopamine transporter. Journal of Medicinal Chemistry. 45: 4371-4. PMID 12213078 DOI: 10.1021/Jm020264R  0.564
2002 Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB. Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist. Proceedings of the National Academy of Sciences of the United States of America. 99: 11934-9. PMID 12192085 DOI: 10.1073/Pnas.182234399  0.422
2002 Hashimoto A, Jacobson AE, Rothman RB, Dersch CM, George C, Flippen-Anderson JL, Rice KC. Probes for narcotic receptor mediated phenomena. Part 28: new opioid antagonists from enantiomeric analogues of 5-(3-hydroxyphenyl)-N-phenylethylmorphan. Bioorganic & Medicinal Chemistry. 10: 3319-29. PMID 12150879 DOI: 10.1016/S0968-0896(02)00219-5  0.36
2002 Baumann MH, Phillips JM, Ayestas MA, Ali SF, Rice KC, Rothman RB. Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence. Annals of the New York Academy of Sciences. 965: 92-108. PMID 12105088 DOI: 10.1111/J.1749-6632.2002.Tb04154.X  0.333
2002 Fantegrossi WE, Ullrich T, Rice KC, Woods JH, Winger G. 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement. Psychopharmacology. 161: 356-64. PMID 12073162 DOI: 10.1007/S00213-002-1021-6  0.643
2002 Baumann MH, Ayestas MA, Sharpe LG, Lewis DB, Rice KC, Rothman RB. Persistent antagonism of methamphetamine-induced dopamine release in rats pretreated with GBR12909 decanoate. The Journal of Pharmacology and Experimental Therapeutics. 301: 1190-7. PMID 12023554 DOI: 10.1124/Jpet.301.3.1190  0.323
2002 Broom DC, Jutkiewicz EM, Folk JE, Traynor JR, Rice KC, Woods JH. Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 744-55. PMID 12007745 DOI: 10.1016/S0893-133X(01)00413-4  0.403
2002 Rothman RB, Carroll FI, Morales M, Rowley DL, Rice KC, Dersch CM, Donovan DM. Studies of the biogenic amine transporters. 10. Characterization of a novel cocaine binding site in brain membranes prepared from dopamine transporter knockout mice. Synapse (New York, N.Y.). 44: 94-105. PMID 11891881 DOI: 10.1002/Syn.10060  0.316
2002 Hsin LW, Dersch CM, Baumann MH, Stafford D, Glowa JR, Rothman RB, Jacobson AE, Rice KC. Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: Chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenylpropyl)piperazine Journal of Medicinal Chemistry. 45: 1321-1329. PMID 11882001 DOI: 10.1021/Jm010430F  0.358
2002 Ko MC, Naughton NN, Traynor JR, Song MS, Woods JH, Rice KC, McKnight AT. Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors. British Journal of Pharmacology. 135: 943-50. PMID 11861322 DOI: 10.1038/Sj.Bjp.0704535  0.411
2002 Stevenson GW, Cañadas F, Gomez-Serrano M, Ullrich T, Zhang X, Rice KC, Riley AL. Delta opioid discrimination learning in the rat: assessment with the selective delta agonist SNC80. Pharmacology, Biochemistry, and Behavior. 71: 283-92. PMID 11812534 DOI: 10.1016/S0091-3057(01)00658-X  0.416
2002 Yu H, Prisinzano T, Dersch CM, Marcus J, Rothman RB, Jacobson AE, Rice KC. Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. Bioorganic & Medicinal Chemistry Letters. 12: 165-8. PMID 11755345 DOI: 10.1016/S0960-894X(01)00689-8  0.611
2002 Hsin LW, Tian X, Webster EL, Coop A, Caldwell TM, Jacobson AE, Chrousos GP, Gold PW, Habib KE, Ayala A, Eckelman WC, Contoreggi C, Rice KC. CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists. Bioorganic & Medicinal Chemistry. 10: 175-83. PMID 11738619 DOI: 10.1016/S0968-0896(01)00261-9  0.608
2002 Yamada K, Flippen-Anderson JL, Jacobson AE, Rice KC. Probes for Narcotic Receptor Mediated Phenomena; 29: Synthesis of rac-(4R,6aR,11bR)-3-Methyl-... Synthesis. 2002: 2359-2364. DOI: 10.1055/S-2002-35237  0.32
2001 Zhang Y, Joseph DB, Bowen WD, Flippen-Anderson JL, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Synthesis and biological evaluation of tropane-like 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909) analogues. Journal of Medicinal Chemistry. 44: 3937-45. PMID 11689080 DOI: 10.1021/Jm0101592  0.333
2001 Ullrich T, Dersch CM, Rothman RB, Jacobson AE, Rice KC. Derivatives of 17-(2-methylallyl)-substituted noroxymorphone: variation of the delta address and its effects on affinity and selectivity for the delta opioid receptor. Bioorganic & Medicinal Chemistry Letters. 11: 2883-2885. PMID 11597422 DOI: 10.1016/S0960-894X(01)00580-7  0.407
2001 Xu H, Lu YF, Rice KC, Ananthan S, Rothman RB. SoRI 9409, a non-peptide opioid mu receptor agonist/delta receptor antagonist, fails to stimulate [35S]-GTP-gamma-S binding at cloned opioid receptors. Brain Research Bulletin. 55: 507-11. PMID 11543951 DOI: 10.1016/S0361-9230(01)00550-0  0.436
2001 Gomez-Flores R, Rice KC, Zhang X, Weber RJ. Increased tumor necrosis factor-alpha and nitric oxide production by rat macrophages following in vitro stimulation and intravenous administration of the delta-opioid agonist SNC 80. Life Sciences. 68: 2675-84. PMID 11400911 DOI: 10.1016/S0024-3205(01)01082-7  0.381
2001 Hosohata Y, Varga EV, Stropova D, Li X, Knapp RJ, Hruby VJ, Rice KC, Nagase H, Roeske WR, Yamamura HI. Mutation W284L of the human delta opioid receptor reveals agonist specific receptor conformations for G protein activation. Life Sciences. 68: 2233-42. PMID 11358332 DOI: 10.1016/S0024-3205(01)01011-6  0.378
2001 McLamore S, Ullrich T, Rothman RB, Xu H, Dersch C, Coop A, Davis P, Porreca F, Jacobson AE, Rice KC. Effect of N-alkyl and N-alkenyl substituents in noroxymorphindole, 17-substituted-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7:2',3'-indolomorphinans, on opioid receptor affinity, selectivity, and efficacy. Journal of Medicinal Chemistry. 44: 1471-4. PMID 11311071 DOI: 10.1021/Jm000511W  0.617
2001 Xu H, Lu YF, Thomas JB, Carroll FI, Rice KC, Rothman RB. Opioid peptide receptor studies. 15. Relative efficacy of 4-[(N-allyl-3-methyl-4-piperidinyl)phenylamino]-N,N-diethylbenzamide and related compounds at the cloned human delta-opioid receptor. Synapse (New York, N.Y.). 40: 269-74. PMID 11309842 DOI: 10.1002/Syn.1049  0.426
2001 Xu H, Hashimoto A, Rice KC, Jacobson AE, Thomas JB, Carroll FI, Lai J, Rothman RB. Opioid peptide receptor studies. 14. Stereochemistry determines agonist efficacy and intrinsic efficacy in the [(35)S]GTP-gamma-S functional binding assay. Synapse (New York, N.Y.). 39: 64-9. PMID 11071711 DOI: 10.1002/1098-2396(20010101)39:1<64::Aid-Syn9>3.0.Co;2-J  0.406
2000 Stafford D, Rice KC, Lewis DB, Glowa JR. Response requirements and unit dose modify the effects of GBR 12909 on cocaine-maintained behavior Experimental and Clinical Psychopharmacology. 8: 539-548. PMID 11127425 DOI: 10.1037//1064-1297.8.4.539  0.301
2000 Gu XH, Yu H, Jacobson AE, Rothman RB, Dersch CM, George C, Flippen-Anderson JL, Rice KC. Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. Journal of Medicinal Chemistry. 43: 4868-76. PMID 11123996 DOI: 10.1021/Jm000329V  0.316
2000 Zhang Y, Rothman RB, Dersch CM, Costa BRd, Jacobson aAE, Rice KC. Synthesis and transporter binding properties of bridged piperazine analogues of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR 12909). Journal of Medicinal Chemistry. 43: 4840-4849. PMID 11123994 DOI: 10.1021/Jm000300R  0.332
2000 Coop A, Jacobson AE, Aceto MD, Harris LS, Traynor JR, Woods JH, Rice KC. N-Cyclohexylethyl-N-noroxymorphindole: a mu-opioid preferring analogue of naltrindole. Bioorganic & Medicinal Chemistry Letters. 10: 2449-51. PMID 11078198 DOI: 10.1016/S0960-894X(00)00479-0  0.61
2000 Ullrich T, Rice KC. A practical synthesis of the serotonin 5-HT(2a) receptor antagonist MDL 100907, its enantiomer and their 3-phenolic derivatives as precursors for [11C ]labeled PET ligands Bioorganic and Medicinal Chemistry. 8: 2427-2432. PMID 11058037 DOI: 10.1016/S0968-0896(00)00175-9  0.331
2000 Briscoe RJ, Cabrera CL, Baird TJ, Rice KC, Woods JH. Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats. Brain Research. 881: 204-7. PMID 11036160 DOI: 10.1016/S0006-8993(00)02742-6  0.371
2000 Stevenson GW, Cañadas F, Zhang X, Rice KC, Riley AL. Morphine discriminative control is mediated by the mu opioid receptor: assessment of delta opioid substitution and antagonism. Pharmacology, Biochemistry, and Behavior. 66: 851-6. PMID 10973525 DOI: 10.1016/S0091-3057(00)00280-X  0.397
2000 Hutchinson AC, Simpson GR, Randall JF, Zhang X, Calderon SN, Rice KC, Riley AL. Assessment of SNC 80 and naltrindole within a conditioned taste aversion design. Pharmacology, Biochemistry, and Behavior. 66: 779-87. PMID 10973516 DOI: 10.1016/S0091-3057(00)00278-1  0.404
2000 Furness MS, Zhang X, Coop A, Jacobson AE, Rothman RB, Dersch CM, Xu H, Porreca F, Rice KC. Probes for narcotic receptor-mediated phenomena. 27. Synthesis and pharmacological evaluation of selective delta-opioid receptor agonists from 4-[(alphaR)-alpha-(2S,5R)-4-substituted-2, 5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and their enantiomers. Journal of Medicinal Chemistry. 43: 3193-6. PMID 10956228 DOI: 10.1021/Jm0001222  0.648
2000 Hsin LW, Webster EL, Chrousos GP, Gold PW, Eckelman WC, Contoreggi C, Rice KC. Synthesis and biological activity of fluoro-substituted pyrrolo[2,3-d]pyrimidines: The development of potential positron emission tomography imaging agents for the corticotropin-releasing hormone type 1 receptor Bioorganic and Medicinal Chemistry Letters. 10: 707-710. PMID 10782669 DOI: 10.1016/S0960-894X(00)00071-8  0.313
2000 Baumann MH, Ayestas MA, Dersch CM, Brockington A, Rice KC, Rothman RB. Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications. Synapse. 36: 102-113. PMID 10767057 DOI: 10.1002/(Sici)1098-2396(200005)36:2<102::Aid-Syn3>3.0.Co;2-#  0.327
2000 Hosohata Y, Vanderah TW, Burkey TH, Ossipov MH, Kovelowski CJ, Sora I, Uhl GR, Zhang X, Rice KC, Roeske WR, Hruby VJ, Yamamura HI, Lai J, Porreca F. delta-Opioid receptor agonists produce antinociception and [35S]GTPgammaS binding in mu receptor knockout mice. European Journal of Pharmacology. 388: 241-8. PMID 10675732 DOI: 10.1016/S0014-2999(99)00897-3  0.398
2000 Kirby LG, Rice KC, Valentino RJ. Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 22: 148-62. PMID 10649828 DOI: 10.1016/S0893-133X(99)00093-7  0.304
2000 Hsin L, Webster EL, Chrousos GP, Gold PW, Eckelman WC, Contoreggi C, Rice KC. Synthesis of [3H](4-fluorobutyl)propyl[2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-yl]amine: a potent radioligand for corticotropin-releasing hormone type 1 receptor Journal of Labelled Compounds and Radiopharmaceuticals. 43: 899-908. DOI: 10.1002/1099-1344(200008)43:9<899::Aid-Jlcr375>3.0.Co;2-N  0.311
1999 Zhang X, Rice KC, Calderon SN, Kayakiri H, Smith L, Coop A, Jacobson AE, Rothman RB, Davis P, Dersch CM, Porreca F. Probes for narcotic receptor mediated phenomena. 26. Synthesis and biological evaluation of diarylmethylpiperazines and diarylmethylpiperidines as novel, nonpeptidic delta opioid receptor ligands. Journal of Medicinal Chemistry. 42: 5455-63. PMID 10639287 DOI: 10.1021/Jm9903895  0.614
1999 Coop A, Pinto J, Wang L, McCullough K, Rothman RB, Dersch C, Jacobson AE, Rice KC. Delta opioid binding selectivity of 3-ether analogs of naltrindole. Bioorganic & Medicinal Chemistry Letters. 9: 3435-8. PMID 10617086 DOI: 10.1016/S0960-894X(99)00622-8  0.619
1999 Lewis DB, Matecka D, Zhang Y, Hsin LW, Dersch CM, Stafford D, Glowa JR, Rothman RB, Rice KC. Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1- [2- [bis (4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents Journal of Medicinal Chemistry. 42: 5029-5042. PMID 10585212 DOI: 10.1021/Jm990291Q  0.355
1999 Heyliger SO, Jackson C, Rice KC, Rothman RB. Opioid peptide receptor studies. 10. Nor-BNI differentially inhibits kappa receptor agonist-induced G-protein activation in the guinea pig caudate: Further evidence of kappa receptor heterogeneity Synapse. 34: 256-265. PMID 10529720 DOI: 10.1002/(Sici)1098-2396(19991215)34:4<256::Aid-Syn2>3.0.Co;2-6  0.399
1999 Romero DV, Partilla JS, Zheng Q, Heyliger SO, Ni Q, Rice KC, Lai J, Rothman RB. Opioid peptide receptor studies. 12. Buprenorphine is a potent and selective mu/kappa antagonist in the [35S]-GTP-gamma-S functional binding assay. Synapse. 34: 83-94. PMID 10502307 DOI: 10.1002/(Sici)1098-2396(199911)34:2<83::Aid-Syn1>3.0.Co;2-S  0.4
1999 Ananthan S, Kezar HS, Carter RL, Saini SK, Rice KC, Wells JL, Davis P, Xu H, Dersch CM, Bilsky EJ, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and biological activities of naltrexone-derived pyrido- and pyrimidomorphinans. Journal of Medicinal Chemistry. 42: 3527-38. PMID 10479286 DOI: 10.1021/Jm990039I  0.429
1999 Villemagne VL, Wong DF, Yokoi F, Stephane M, Rice KC, Matecka D, Clough DJ, Dannals RF, Rothman RB. GBR12909 attenuates amphetamine-induced striatal dopamine release as measured by [(11)C]raclopride continuous infusion PET scans. Synapse (New York, N.Y.). 33: 268-73. PMID 10421707 DOI: 10.1002/(Sici)1098-2396(19990915)33:4<268::Aid-Syn3>3.0.Co;2-W  0.31
1999 Li JG, Chen C, Yin J, Rice K, Zhang Y, Matecka D, de Riel JK, DesJarlais RL, Liu-Chen LY. ASP147 in the third transmembrane helix of the rat mu opioid receptor forms ion-pairing with morphine and naltrexone. Life Sciences. 65: 175-85. PMID 10416823 DOI: 10.1016/S0024-3205(99)00234-9  0.42
1999 Coop A, Rothman RB, Dersch C, Partilla J, Porreca F, Davis P, Jacobson AE, Rice KC. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole. Journal of Medicinal Chemistry. 42: 1673-9. PMID 10229636 DOI: 10.1021/Jm9807003  0.628
1999 Villemagne VL, Rothman RB, Yokoi F, Rice KC, Matecka D, Dannals RF, Wong DF. Doses of GBR12909 that suppress cocaine self-administration in non-human primates substantially occupy dopamine transporters as measured by [11C] WIN35,428 PET scans. Synapse (New York, N.Y.). 32: 44-50. PMID 10188637 DOI: 10.1002/(Sici)1098-2396(199904)32:1<44::Aid-Syn6>3.0.Co;2-9  0.324
1999 Xu H, Lu Y, Partilla JS, Zheng Q, Wang J, Brine GA, Carroll FI, Rice KC, Chen K, Chi Z, Rothman RB. Opioid peptide receptor studies, 11: involvement of Tyr148, Trp318 and His319 of the rat mu-opioid receptor in binding of mu-selective ligands. Synapse. 32: 23-28. PMID 10188634 DOI: 10.1002/(Sici)1098-2396(199904)32:1<23::Aid-Syn3>3.0.Co;2-N  0.408
1999 Aceto MD, Harris LS, Abood ME, Rice KC. Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine. European Journal of Pharmacology. 365: 143-7. PMID 9988096 DOI: 10.1016/S0014-2999(98)00862-0  0.421
1999 Coop A, Rice KC. Direct and Simple Conversion of Codeine to Thebainone-A and Dihydrothebainone Heterocycles. 50: 39-42. DOI: 10.3987/Com-98-S(H)15  0.502
1999 Coop A, Rice KC. Studies into the direct oxidation of codeinone to 14-hydroxycodeinone Tetrahedron. 55: 11429-11436. DOI: 10.1016/S0040-4020(99)00665-1  0.502
1998 Kubota H, Rothman RB, Dersch C, McCullough K, Pinto J, Rice KC. Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives. Bioorganic & Medicinal Chemistry Letters. 8: 799-804. PMID 9871544 DOI: 10.1016/S0960-894X(98)00105-X  0.421
1998 Zhang Y, Williams W, Torrence-Campbell C, Bowen WD, Rice KC. Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands. Journal of Medicinal Chemistry. 41: 4950-7. PMID 9836612 DOI: 10.1021/Jm980143K  0.361
1998 Ni Q, Xu H, Partilla JS, Rice KC, Matecka D, Calderon SN, Porreca F, Lai J, Schmidhammer H, Krassnig R, Rothman RB. Opioid peptide receptor studies. 9. Identification of a novel non-mu- non-delta-like opioid peptide binding site in rat brain. Peptides. 19: 1079-90. PMID 9700759 DOI: 10.1016/S0196-9781(98)00046-1  0.36
1998 Schweri MM, De Costa BR, Rice KC. Fourphit, an acylating phencyclidine derivative, attenuates cocaine- induced hyperactivity in rats Pharmacology Biochemistry and Behavior. 60: 615-623. PMID 9678644 DOI: 10.1016/S0091-3057(98)00040-9  0.366
1998 Ananthan S, Johnson CA, Carter RL, Clayton SD, Rice KC, Xu H, Davis P, Porreca F, Rothman RB. Synthesis, opioid receptor binding, and bioassay of naltrindole analogues substituted in the indolic benzene moiety. Journal of Medicinal Chemistry. 41: 2872-81. PMID 9667975 DOI: 10.1021/Jm980083I  0.433
1998 Rothman RB, Silverthorn ML, Glowa JR, Matecka D, Rice KC, Carroll FI, Partilla JS, Uhl GR, Vandenbergh DJ, Dersch CM. Studies of the biogenic amine transporters. VII. Characterization of a novel cocaine binding site identified with [125I]RTI-55 in membranes prepared from human, monkey and guinea pig caudate. Synapse (New York, N.Y.). 28: 322-38. PMID 9517841 DOI: 10.1002/(Sici)1098-2396(199804)28:4<322::Aid-Syn8>3.0.Co;2-B  0.325
1998 Xu H, Lu YF, Partilla JS, Pinto J, Calderon SN, Matecka D, Rice KC, Lai J, Porreca F, Ananthan S, Rothman RB. Opioid peptide receptor studies. 8. One of the mouse brain deltaNCX binding sites is similar to the cloned mouse opioid delta receptor: further evidence for heterogeneity of delta opioid receptors. Peptides. 19: 343-50. PMID 9493867 DOI: 10.1016/S0196-9781(97)00294-5  0.403
1998 Lu YF, Xu H, Liu-Chen LY, Chen C, Partilla JS, Brine GA, Carroll FI, Rice KC, Lai J, Porreca F, Sadee W, Rothman RB. Opioid peptide receptor studies. 7. The methylfentanyl congener RTI-4614-4 and its four enantiomers bind to different domains of the rat mu opioid receptor. Synapse (New York, N.Y.). 28: 117-24. PMID 9450512 DOI: 10.1002/(Sici)1098-2396(199802)28:2<117::Aid-Syn2>3.0.Co;2-E  0.417
1998 Coop A, Rice KC. A Novel Synthesis Of Thebaine From Codeine Heterocycles. 49: 43-47. DOI: 10.3987/Com-98-S8  0.524
1998 Coop A, Janetka JW, Lewis JW, Rice KC. L-Selectride as a general reagent for the O-demethylation and N-decarbomethoxylation of opium alkaloids and derivatives Journal of Organic Chemistry. 63: 4392-4396. DOI: 10.1021/Jo9801972  0.741
1998 Coop A, Rice KC. L-Selectride as a convenient reagent for the selective cleavage of carbamates Tetrahedron Letters. 39: 8933-8934. DOI: 10.1016/S0040-4039(98)02018-8  0.53
1997 Katsura Y, Zhang X, Homma K, Rice KC, Calderon SN, Rothman RB, Yamamura HI, Davis P, Flippen-Anderson JL, Xu H, Becketts K, Foltz EJ, Porreca F. Probes for narcotic receptor-mediated phenomena. 25. Synthesis and evaluation of N-alkyl-substituted (alpha-piperazinylbenzyl)benzamides as novel, highly selective delta opioid receptor agonists. Journal of Medicinal Chemistry. 40: 2936-47. PMID 9288176 DOI: 10.1021/Jm970106D  0.421
1997 Quock RM, Hosohata Y, Knapp RJ, Burkey TH, Hosohata K, Zhang X, Rice KC, Nagase H, Hruby VJ, Porreca F, Roeske WR, Yamamura HI. Relative efficacies of delta-opioid receptor agonists at the cloned human delta-opioid receptor. European Journal of Pharmacology. 326: 101-4. PMID 9178661 DOI: 10.1016/S0014-2999(97)83488-7  0.41
1997 Calderon SN, Rice KC, Rothman RB, Porreca F, Flippen-Anderson JL, Kayakiri H, Xu H, Becketts K, Smith LE, Bilsky EJ, Davis P, Horvath R. Probes for narcotic receptor mediated phenomena. 23. Synthesis, opioid receptor binding, and bioassay of the highly selective delta agonist (+)-4-[(alpha R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]- N,N-diethylbenzamide (SNC 80) and related novel nonpeptide delta opioid receptor ligands. Journal of Medicinal Chemistry. 40: 695-704. PMID 9057856 DOI: 10.1021/Jm960319N  0.442
1997 Staley JK, Rothman RB, Rice KC, Partilla J, Mash DC. κ2Opioid Receptors in Limbic Areas of the Human Brain Are Upregulated by Cocaine in Fatal Overdose Victims The Journal of Neuroscience. 17: 8225-8233. DOI: 10.1523/Jneurosci.17-21-08225.1997  0.371
1996 Coop A, Lewis JW, Rice KC. Direct and Simple O-Demethylation of Thebaine to Oripavine. The Journal of Organic Chemistry. 61: 6774. PMID 11667567 DOI: 10.1021/Jo961473K  0.597
1996 Glowa JR, Fantegrossi WE, Lewis DB, Matecka D, Rice KC, Rothman RB. Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3- phenylpropyl)piperazinyl decanoate, a long-acting ester derivative of GBR 12909 Journal of Medicinal Chemistry. 39: 4689-4691. PMID 8941381 DOI: 10.1021/Jm960551T  0.612
1996 Webster EL, Lewis DB, Torpy DJ, Zachman EK, Rice KC, Chrousos GP. In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: Suppression of pituitary ACTH release and peripheral inflammation Endocrinology. 137: 5747-5750. PMID 8940412 DOI: 10.1210/Endo.137.12.8940412  0.307
1996 Staley JK, Ouyang Q, Pablo J, Hearn WL, Flynn DD, Rothman RB, Rice KC, Mash DC. Pharmacological screen for activities of 12-hydroxyibogamine: A primary metabolite of the indole alkaloid ibogaine Psychopharmacology. 127: 10-18. PMID 8880938 DOI: 10.1007/Bf02805969  0.337
1996 Elmer GI, Brockington A, Gorelick DA, Carrol FI, Rice KC, Matecka D, Goldberg SR, Rothman RB. Cocaine cross-sensitization to dopamine uptake inhibitors: Unique effects of GBR12909 Pharmacology Biochemistry and Behavior. 53: 911-918. PMID 8801597 DOI: 10.1016/0091-3057(95)02143-4  0.308
1996 Zhang Y, Williams W, Bowen WD, Rice KC. Synthesis and evaluation of aryl-substituted N-(arylethyl)-N-methyl-2-(1-pyrrolidinyl)ethylamines and corresponding arylacetamides for sigma receptor affinity. Journal of Medicinal Chemistry. 39: 3564-8. PMID 8784455 DOI: 10.1021/Jm9600813  0.361
1996 Matsumoto RR, Bowen WD, Walker JM, Patrick SL, Zambon AC, Vo VN, Truong DD, De Costa BR, Rice KC. Dissociation of the motor effects of (+)-pentazocine from binding to sigma 1 sites. European Journal of Pharmacology. 301: 31-40. PMID 8773444 DOI: 10.1016/0014-2999(96)00008-8  0.376
1996 Bertha CM, Ellis M, Flippen-Anderson JL, Porreca F, Rothman RB, Davis P, Xu H, Becketts K, Rice KC. Probes for narcotic receptor-mediated phenomena. 21. Novel derivatives of 3-(1,2,3,4,5,11-hexahydro-3-methyl-2,6-methano-6H-azocino[4,5-b]indol- 6-yl)-phenols with improved delta opioid receptor selectivity. Journal of Medicinal Chemistry. 39: 2081-6. PMID 8642567 DOI: 10.1021/Jm950695S  0.408
1996 Zhu J, Yin J, Law PY, Claude PA, Rice KC, Evans CJ, Chen C, Yu L, Liu-Chen LY. Irreversible binding of cis-(+)-3-methylfentanyl isothiocyanate to the delta opioid receptor and determination of its binding domain. The Journal of Biological Chemistry. 271: 1430-4. PMID 8576134 DOI: 10.1074/Jbc.271.3.1430  0.398
1996 Costa BRd, He X, Dominguez C, Williams W, Rice KC, Bowen WD. The role of novel ligands in the biological characterization of sigma receptors Pharmacochemistry Library. 24: 313-320. DOI: 10.1016/S0165-7208(96)80025-0  0.371
1996 Calderon SN, Bertha CM, Gutkind JS, Xu H, Partilla JS, Rothman RB, Rice KC. Probes for narcotic receptor mediated phenomena 22. (1) synthesis and characterization of optically pure [3H](+)-4-[(αR)-α-((2S, 5R)-4-propyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N, N-diethylbenzamide, [3H]SNC 121, a novel high affinity and select Journal of Labelled Compounds and Radiopharmaceuticals. 38: 847-850. DOI: 10.1002/(Sici)1099-1344(199609)38:9<847::Aid-Jlcr900>3.0.Co;2-N  0.376
1995 Cha XY, Xu H, Ni Q, Partilla JS, Rice KC, Matecka D, Calderon SN, Porreca F, Lai J, Rothman RB. Opioid peptide receptor studies. 4. Antisense oligodeoxynucleotide to the delta opioid receptor delineates opioid receptor subtypes Regulatory Peptides. 59: 247-253. PMID 8584761 DOI: 10.1016/0167-0115(95)00095-S  0.396
1995 Ni Q, Xu H, Partilla JS, Costa BRd, Rice KC, Kayakiri H, Rothman RB. Opioid peptide receptor studies. 3. Interaction of opioid peptides and other drugs with four subtypes of the κ2 receptor in guinea pig brain Peptides. 16: 1083-1095. PMID 8532593 DOI: 10.1016/0196-9781(95)00091-W  0.351
1995 Rothman RB, Xu H, Wang JB, Partilla JS, Kayakiri H, Rice KC, Uhl GR. Ligand selectivity of cloned human and rat opioid mu receptors. Synapse (New York, N.Y.). 21: 60-4. PMID 8525463 DOI: 10.1002/Syn.890210109  0.407
1995 Cha XY, Xu H, Rice KC, Porreca F, Lai J, Ananthan S, Rothman RB. Opioid peptide receptor studies. 1. Identification of a novel delta-opioid receptor binding site in rat brain membranes. Peptides. 16: 191-8. PMID 7784248 DOI: 10.1016/0196-9781(94)00182-0  0.376
1995 Bertha CM, Flippen-Anderson JL, Rothman RB, Porreca F, Davis P, Xu H, Becketts K, Cha XY, Rice KC. Probes for narcotic receptor-mediated phenomena. 20. Alteration of opioid receptor subtype selectivity of the 5-(3-hydroxyphenyl)morphans by application of the message-address concept: preparation of delta-opioid receptor ligands. Journal of Medicinal Chemistry. 38: 1523-37. PMID 7739011 DOI: 10.1021/Jm00009A013  0.427
1995 Xu H, Goodman CB, Partilla JS, Ni Q, Kayakiri H, Rice KC, Rothman RB. 6 beta-[125iodo]-3, 14-dihydroxy-17-methyl-4, 5 alpha-epoxymorphinan ([125I]IOXY-AGO): a potent and selective radioligand for opioid mu receptors. Synapse. 19: 105-111. PMID 7725239 DOI: 10.1002/Syn.890190206  0.421
1995 Bowen WD, Bertha CM, Vilner BJ, Rice KC. CB-64D and CB-184: ligands with high sigma 2 receptor affinity and subtype selectivity. European Journal of Pharmacology. 278: 257-60. PMID 7589164 DOI: 10.1016/0014-2999(95)00176-L  0.35
1995 Bertha CM, Vilner BJ, Mattson MV, Bowen WD, Becketts K, Xu H, Rothman RB, Flippen-Anderson JL, Rice KC. (E)-8-benzylidene derivatives of 2-methyl-5-(3-hydroxyphenyl)morphans: highly selective ligands for the sigma 2 receptor subtype. Journal of Medicinal Chemistry. 38: 4776-85. PMID 7490727 DOI: 10.1021/Jm00024A005  0.409
1994 Dersch CM, Akunne HC, Partilla JS, Char GU, de Costa BR, Rice KC, Carroll FI, Rothman RB. Studies of the biogenic amine transporters. 1. Dopamine reuptake blockers inhibit [3H]mazindol binding to the dopamine transporter by a competitive mechanism: preliminary evidence for different binding domains. Neurochemical Research. 19: 201-8. PMID 8183430 DOI: 10.1007/Bf00966817  0.314
1994 Petrov ES, Varlinskaya EI, Robinson SR, Smotherman WP, de Costa BR, Rice KC. Kappa opioid effects on fetal behavior: central administration of U50,488. Physiology & Behavior. 56: 175-82. PMID 8084898 DOI: 10.1016/0031-9384(94)90276-3  0.369
1994 Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. Journal of Medicinal Chemistry. 37: 2125-8. PMID 8035418 DOI: 10.1021/Jm00040A002  0.364
1994 Raulli RE, Jackson B, Tandon N, Mattson M, Rice K, Jamieson GA. Phencyclidine inhibits epinephrine-stimulated platelet aggregation independently of high affinity N-methyl-D-aspartate (NMDA)-type glutamatereceptors. Biochimica Et Biophysica Acta. 1224: 175-80. PMID 7981230 DOI: 10.1016/0167-4889(94)90188-0  0.303
1994 Raffa RB, Kim A, Rice KC, de Costa BR, Codd EE, Rothman RB. Low affinity of FMRFamide and four FaRPs (FMRFamide-related peptides), including the mammalian-derived FaRPs F-8-Famide (NPFF) and A-18-Famide, for opioid mu, delta, kappa 1, kappa 2a, or kappa 2b receptors. Peptides. 15: 401-4. PMID 7937312 DOI: 10.1016/0196-9781(94)90195-3  0.383
1994 Bertha CM, Mattson MV, Flippen-Anderson JL, Rothman RB, Xu H, Cha XY, Becketts K, Rice KC. A marked change of receptor affinity of the 2-methyl-5-(3-hydroxyphenyl)morphans upon attachment of an (E)-8-benzylidene moiety: synthesis and evaluation of a new class of sigma receptor ligands. Journal of Medicinal Chemistry. 37: 3163-70. PMID 7932540 DOI: 10.1021/Jm00045A022  0.396
1994 Smotherman WP, Robinson SR, Varlinskaya EI, Petrov ES, Orlowski M, de Costa BR, Rice KC. Central administration of the endopeptidase 24.15 inhibitor cFP-AAF-pAB suggests dynorphin as the endogenous ligand underlying behavioral effects of milk in the fetal rat. Pharmacology, Biochemistry, and Behavior. 47: 715-9. PMID 7911578 DOI: 10.1016/0091-3057(94)90178-3  0.397
1994 Ni Q, Xu H, Partilla JS, Costa BRd, Rice KC, Borsodi A, Hosztafi S, Rothman RB. Dihydrocodeinone-hydrazone, dihydrocodeinone-oxime, naloxone-3-ome-oxime, and clocinnamox fail to irreversibly inhibit opioid kappa receptor binding Neurochemical Research. 19: 1159-1163. PMID 7824069 DOI: 10.1007/Bf00965150  0.405
1994 Xu H, Partilla JS, Becketts KM, Kayakiri H, Rice KC, Rothman RB. [125I]IOXY-AGO: A high affinity, mu-selective agonist opioid receptor ligand Regulatory Peptides. 54: 331-332. DOI: 10.1016/0167-0115(94)90523-1  0.417
1994 Rothman RB, Xu H, Wang JB, Partilla JS, Kayakiri H, Rice KC, Uhl GR. The ligand-selectivity of cloned human and rat opiate mu receptors studied with [125I]IOXY-AGO Regulatory Peptides. 54: 249-250. DOI: 10.1016/0167-0115(94)90483-9  0.379
1994 Ni Q, Xu H, Partilla J, Porreca F, Calderon S, Rice K, Smith L, McNutt R, Rothman R. [3H]SNC121: A novel high affinity ligand for rat brain delta receptors: Preliminary studies Regulatory Peptides. 54: 209-210. DOI: 10.1016/0167-0115(94)90464-2  0.389
1994 Cha XY, Xu H, Calderon SN, Smith LE, Rice KC, Porreca F, Rothman RB. BW373U86, its enantiomers, and related compounds: Interactions of non-peptide delta agonists at multiple δcx binding sites in rat brain Regulatory Peptides. 54: 45-46. DOI: 10.1016/0167-0115(94)90381-6  0.35
1994 Bilsky EJ, Bernstein RN, Davis P, Calderon SN, Rice KC, Rothman RB, Porreca F. Characterization of enantiomers of (±)BW373U86 and related compounds: Highly selective non-peptidic delta opioid agonists Regulatory Peptides. 54: 25-26. DOI: 10.1016/0167-0115(94)90371-9  0.326
1994 He X, Matecka D, Lee KS, Gu ZQ, Rice KC, Wong G, Skolnick P, De Costa BR. Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors Journal of Labelled Compounds and Radiopharmaceuticals. 34: 27-32. DOI: 10.1002/Jlcr.2580340105  0.323
1993 Rothman RB, Lewis B, Dersch C, Xu H, Radesca L, Costa BRD, Rice KC, Kilburn RB, Akunne HC, Pert A. Identification of a GBR12935 homolog, LR1111, which is over 4,000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters. Synapse. 14: 34-39. PMID 8511716 DOI: 10.1002/Syn.890140106  0.311
1993 Rothman RB, Becketts KM, Radesca LR, Costa BRd, Rice KC, Carroll FI, Dersch CM. Studies of the biogenic amine transporters. II. A brief study on the use of [3H]DA-uptake-inhibition to transporter-binding-inhibition ratios for the in vitro evaluation of putative cocaine antagonists. Life Sciences. 53. PMID 8412496 DOI: 10.1016/0024-3205(93)90602-Y  0.344
1993 Lipovac MN, Debler EA, Zlokovic BV, Jacobson AE, Rice KC, de Costa B, Selmeci G, Chi L, Reith ME. Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain. Epilepsia. 34: 211-9. PMID 8384107 DOI: 10.1111/J.1528-1157.1993.Tb02401.X  0.341
1993 Rothman RB, Xu H, Char GU, Kim A, De Costa BR, Rice KC, Zimmerman DM. Phenylpiperidine opioid antagonists that promote weight loss in rats have high affinity for the kappa 2B (enkephalin-sensitive) binding site. Peptides. 14: 17-20. PMID 8382809 DOI: 10.1016/0196-9781(93)90005-2  0.363
1993 Linders JTM, Monn JA, Mattson MV, George C, Jacobson AE, Rice KC. Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new, potent and selective electrophilic affinity ligand for the NMDA receptor-coupled phencyclidine binding site Journal of Medicinal Chemistry. 36: 2499-2507. PMID 8355251 DOI: 10.1021/Jm00069A008  0.35
1993 Xu H, Partilla JS, Costa BRd, Rice KC, Rothman RB. Differential binding of opioid peptides and other drugs to two subtypes of opioid binding sites in mouse brain: Further evidence for δ receptor heterogeneity Peptides. 14: 893-907. PMID 8284266 DOI: 10.1016/0196-9781(93)90064-N  0.369
1993 Ni Q, Xu H, Partilla JS, Costa BRD, Rice KC, Rothman RB. Selective labeling of κ2 opioid receptors in rat brain by [125I]IOXY: Interaction of opioid peptides and other drugs with multiple κ2a binding sites Peptides. 14: 1279-1293. PMID 8134311 DOI: 10.1016/0196-9781(93)90188-M  0.398
1992 Carr DJJ, Radulescu RT, Decosta BR, Rice KC, Blalock JE. Opioid modulation of immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen. Annals of the New York Academy of Sciences. 650: 125-127. PMID 1605469 DOI: 10.1111/J.1749-6632.1992.Tb49108.X  0.305
1992 Rothman RB, Grieg N, Kim A, Costa BRd, Rice KC, Carroll FI, Pert A. Cocaine and GBR12909 produce equivalent motoric responses at different occupancy of the dopamine transporter Pharmacology, Biochemistry and Behavior. 43: 1135-1142. PMID 1475296 DOI: 10.1016/0091-3057(92)90493-Y  0.321
1992 Akunne HC, Costa BRd, Jacobson AE, Rice KC, Rothman RB. [3H] cocaine labels a binding site associated with the serotonin transporter in guinea pig brain: allosteric modulation by paroxetine. Neurochemical Research. 17: 1275-1283. PMID 1461373 DOI: 10.1007/Bf00968412  0.319
1992 Reith ME, de Costa B, Rice KC, Jacobson AE. Evidence for mutually exclusive binding of cocaine, BTCP, GBR 12935, and dopamine to the dopamine transporter. European Journal of Pharmacology. 227: 417-25. PMID 1446712 DOI: 10.1016/0922-4106(92)90160-W  0.33
1992 France CP, Winger G, Seggel MR, Rice KC, Woods JH. Pharmacological profile of a potent, efficacious fentanyl derivative in rhesus monkeys. Psychopharmacology. 109: 291-8. PMID 1365629 DOI: 10.1007/Bf02245876  0.38
1992 Thurkauf A, Mattson MV, Richardson S, Mirsadeghi S, Ornstein PL, Harrison EA, Rice KC, Jacobson AE, Monn JA. Analogues of the dioxolanes dexoxadrol and etoxadrol as potential phencyclidine-like agents. Synthesis and structure-activity relationships. Journal of Medicinal Chemistry. 35: 1323-9. PMID 1349351 DOI: 10.1021/Jm00086A001  0.301
1992 Xu H, Partilla JS, Costa BRd, Rice KC, Rothman RB. Interaction of opioid peptides and other drugs with multiple δncx binding sites in rat brain: Further evidence for heterogeneity Peptides. 13: 1207-1213. PMID 1337380 DOI: 10.1016/0196-9781(92)90030-7  0.335
1992 Rothman RB, Mahboubi A, Bykov V, Kim C, Costa BRd, Jacobson AE, Rice KC. Probing the opioid receptor complex with (+)-trans-SUPERFIT. II. Evidence that μ ligands are noncompetitive inhibitors of the δcx opioid peptide binding site Peptides. 13: 1137-1143. PMID 1337378 DOI: 10.1016/0196-9781(92)90020-4  0.345
1992 Rothman RB, Bykov V, Xue BG, Xu H, De Costa BR, Jacobson AE, Rice KC, Kleinman JE, Brady LS. Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences. Peptides. 13: 977-87. PMID 1336192 DOI: 10.1016/0196-9781(92)90059-C  0.36
1992 Rothman RB, Bykov V, Jacobson AE, Rice KC, Long JE, Bowen WD. A study of the effect of the irreversible delta receptor antagonist [D-Ala2,Leu5,Cys6]-enkephalin on delta cx and delta ncx opioid binding sites in vitro and in vivo. Peptides. 13: 691-4. PMID 1331996 DOI: 10.1016/0196-9781(92)90174-2  0.396
1992 de Costa BR, Iadarola MJ, Rothman RB, Berman KF, George C, Newman AH, Mahboubi A, Jacobson AE, Rice KC. Probes for narcotic receptor mediated phenomena. 18. Epimeric 6 alpha- and 6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinans as potential ligands for opioid receptor single photon emission computed tomography: synthesis, evaluation, and radiochemistry of [125I]-6 beta-iodo-3,14-dihydroxy-17-(cyclopropylmethyl)-4,5 alpha-epoxymorphinan. Journal of Medicinal Chemistry. 35: 2826-35. PMID 1322988 DOI: 10.1021/Jm00093A016  0.554
1992 Gu ZQ, De Costa BR, Wong G, Rice KC, Skolnick P. Synthesis of [3H]tert-butyl 8-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4-benzodiazepi ne 3-carboxylate, a selective, high affinity ligand for the diazepam insensitive (DI) subtype of the benzodiazepine receptor Journal of Labelled Compounds and Radiopharmaceuticals. 31: 1049-1055. DOI: 10.1002/Jlcr.2580311213  0.326
1991 Sawada Y, Kawai R, McManaway M, Otsuki H, Rice KC, Patlak CS, Blasberg RG. Kinetic analysis of transport and opioid receptor binding of [3H](-)-cyclofoxy in rat brain in vivo: implications for human studies. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11: 183-203. PMID 1847702 DOI: 10.1038/Jcbfm.1991.51  0.379
1991 Rothman RB, Mele A, Reid AA, Akunne HC, Greig N, Thurkauf A, de Costa BR, Rice KC, Pert A. GBR12909 antagonizes the ability of cocaine to elevate extracellular levels of dopamine Pharmacology, Biochemistry and Behavior. 40: 387-397. PMID 1839568 DOI: 10.1016/0091-3057(91)90570-R  0.346
1991 Ferrarese C, Guidotti A, Costa E, Miletich RS, Rice KC, de Costa BR, Fulham MJ, Di Chiro G. In vivo study of NMDA-sensitive glutamate receptor by fluorothienylcyclohexylpiperidine [correction of fluorothienylcycloexylpiperidine], a possible ligand for positron emission tomography. Neuropharmacology. 30: 899-905. PMID 1685770 DOI: 10.1016/0028-3908(91)90125-U  0.32
1991 Xu H, Ni Q, Jacobson AE, Rice KC, Rothman RB. Preliminary ligand binding data for subtypes of the delta opioid receptor in rat brain membranes. Life Sciences. 49. PMID 1681403 DOI: 10.1016/0024-3205(91)90204-O  0.318
1991 Rothman RB, Bykov V, Mahboubi A, Long JB, Jiang Q, Porreca F, de Costa BR, Jacobson AE, Rice KC, Holaday JW. Interaction of beta-funaltrexamine with [3H]cycloFOXY binding in rat brain: further evidence that beta-FNA alkylates the opioid receptor complex. Synapse (New York, N.Y.). 8: 86-99. PMID 1652797 DOI: 10.1002/Syn.890080203  0.383
1991 Xu H, Kim CH, Zhu YC, Weber RJ, Jacobson AE, Rice KC, Rothman RB. (+)-cis-3-methylfentanyl and its analogs bind pseudoirreversibly to the mu opioid binding site: evidence for pseudoallosteric modulation. Neuropharmacology. 30: 455-62. PMID 1650928 DOI: 10.1016/0028-3908(91)90006-W  0.347
1991 Contreras PC, Ragan DM, Bremer ME, Lanthorn TH, Gray NM, Iyengar S, Jacobson AE, Rice KC, de Costa BR. Evaluation of U-50,488H analogs for neuroprotective activity in the gerbil. Brain Research. 546: 79-82. PMID 1649669 DOI: 10.1016/0006-8993(91)91161-S  0.398
1991 Rothman RB, Mahboubi A, Bykov V, Kim CH, Jacobson AE, Rice KC. Probing the opioid receptor complex with (+)-trans-superfit. I. Evidence that [D-Pen2,D-Pen5]enkephalin interacts with high affinity at the delta cx binding site. Peptides. 12: 359-64. PMID 1648715 DOI: 10.1016/0196-9781(91)90026-L  0.356
1991 Witkin JM, Johnson RE, Jaffe JH, Goldberg SR, Grayson NA, Rice KC, Katz JL. The partial opioid agonist, buprenorphine, protects against lethal effects of cocaine. Drug and Alcohol Dependence. 27: 177-84. PMID 1647294 DOI: 10.1016/0376-8716(91)90037-Y  0.397
1991 Rothman RB, Long JB, Bykov V, Xu H, Jacobson AE, Rice KC, Holaday JW. Upregulation of the opioid receptor complex by the chronic administration of morphine: a biochemical marker related to the development of tolerance and dependence. Peptides. 12: 151-60. PMID 1646998 DOI: 10.1016/0196-9781(91)90182-O  0.412
1991 Carr DJJ, DeCosta BR, Jacobson AE, Rice KC, Blalock JE. Enantioselective kappa opioid binding sites on the macrophage cell line, P388d1. Life Sciences. 49: 45-51. PMID 1646923 DOI: 10.1016/0024-3205(91)90578-Y  0.32
1991 Kawai R, Carson RE, Dunn B, Newman AH, Rice KC, Blasberg RG. Regional brain measurement of Bmax and KD with the opiate antagonist cyclofoxy: equilibrium studies in the conscious rat. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 11: 529-44. PMID 1646826 DOI: 10.1038/Jcbfm.1991.102  0.536
1991 Rothman RB, Xu H, Seggel M, Jacobson AE, Rice KC, Brine GA, Carroll FI. RTI-4614-4: an analog of (+)-cis-3-methylfentanyl with a 27,000-fold binding selectivity for mu versus delta opioid binding sites. Life Sciences. 48. PMID 1646357 DOI: 10.1016/0024-3205(91)90346-D  0.381
1991 Grayson NA, Costa BRd, Linders JTM, Rice KC. An expedient synthesis of high specific activity tritium labelled 4-fluoro-1-[1-(2-thienyl)]cyclohexylpiperidine ([3H]FTCP), a ligand for further characterization of the phencyclidine/NMDA receptor complex Journal of Labelled Compounds and Radiopharmaceuticals. 29: 919-926. DOI: 10.1002/Jlcr.2580290808  0.313
1990 Thurkauf A, de Costa B, Mattson MV, France CP, Price MT, Olney JW, Woods JH, Jacobson AE, Rice KC. Synthesis, phencyclidine-like pharmacology, and antiischemic potential of meta-substituted 1-(1-phenylcyclohexyl)-1,2,3,6-tetrahydropyridines. Journal of Medicinal Chemistry. 33: 2211-5. PMID 2374147 DOI: 10.1021/Jm00170A027  0.334
1990 Kawai R, Sawada Y, Channing M, Newman AH, Rice KC, Blasberg RG. BBB transport and rapid tissue binding of cyclofoxy: comparison of active and inactive enantiomers. The American Journal of Physiology. 259: H1278-87. PMID 2221131 DOI: 10.1152/Ajpheart.1990.259.4.H1278  0.531
1990 Band L, Xu H, Bykov V, Greig N, Chong-Ho Kim, Newman A, Jacobson AE, Rice KC, Rothman RB. The potent opioid agonist, (+)-cis-3-methylfentanyl binds pseudoirreversibly to the opioid receptor complex in vitro and in vivo: Evidence for a novel mechanism of action Life Sciences. 47: 2231-2240. PMID 2176265 DOI: 10.1016/0024-3205(90)90154-J  0.389
1990 Carr DJJ, Radulescu RT, deCosta BR, Rice KC, Blalock JE. Differential effect of opioids on immunoglobulin production by lymphocytes isolated from Peyer's patches and spleen. Life Sciences. 47: 1059-1069. PMID 2172675 DOI: 10.1016/0024-3205(90)90479-B  0.369
1990 McCabe RT, Costa BRd, Miller RL, Havunjian RH, Rice KC, Skolnick P. Characterization of benzodiazepine receptors with fluorescent ligands. The Faseb Journal. 4: 2934-2940. PMID 2165950 DOI: 10.1096/Fasebj.4.11.2165950  0.317
1990 Rothman RB, Bykov V, de Costa BR, Jacobson AE, Rice KC, Brady LS. Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain. Peptides. 11: 311-31. PMID 2162533 DOI: 10.1016/0196-9781(90)90088-M  0.358
1990 Carr DJJ, DeCosta BR, Kim CH, Jacobson AE, Bost KL, Rice KC, Blalock JE. Anti-opioid receptor antibody recognition of a binding site on brain and leukocyte opioid receptors Neuroendocrinology. 51: 552-560. PMID 2162012 DOI: 10.1159/000125390  0.405
1990 Carr DJ, DeCosta BR, Jacobson AE, Rice KC, Blalock JE. Corticotropin-releasing hormone augments natural killer cell activity through a naloxone-sensitive pathway. Journal of Neuroimmunology. 28: 53-61. PMID 2160475 DOI: 10.1016/0165-5728(90)90040-T  0.35
1990 Monn JA, Thurkauf A, Mattson MV, Jacobson AE, Rice KC. Synthesis and structure-activity relationship of C5-substituted analogues of (+-)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine [(+-)-desmethyl-MK801]: ligands for the NMDA receptor-coupled phencyclidine binding site. Journal of Medicinal Chemistry. 33: 1069-1076. PMID 2155320 DOI: 10.1021/Jm00165A029  0.352
1990 Nabeshima T, Yoshida S, Morinaka H, Kameyama T, Thurkauf A, Rice KC, Jacobson AE, Monn JA, Cho AK. MK-801 ameliorates delayed amnesia, but potentiates acute amnesia induced by CO. Neuroscience Letters. 108: 321-327. PMID 2154727 DOI: 10.1016/0304-3940(90)90661-R  0.303
1990 Reid AA, Mattson MV, de Costa BR, Thurkauf A, Jacobson AE, Monn JA, Rice KC, Rothman RB. Specificity of phencyclidine-like drugs and benzomorphan opiates for two high affinity phencyclidine binding sites in guinea pig brain. Neuropharmacology. 29: 811-7. PMID 1963480 DOI: 10.1016/0028-3908(90)90154-J  0.315
1990 Rothman RB, Long JB, Bykov V, Jacobson AE, Rice KC, Holaday JW. Pretreatment of rats with the irreversible mu-receptor antagonist, beta-FNA, fails to prevent naltrexone-induced upregulation of mu-opioid receptors. Neuropharmacology. 29: 805-10. PMID 1963479 DOI: 10.1016/0028-3908(90)90153-I  0.416
1990 Costa BRD, Thurkauf A, Rothman RR, Jacobson AE, Rice KC. Synthesis of high specific activity tritium labelled 1S,2S‐(‐)‐trans‐2‐isothiocyanato‐N‐methyl‐N‐[2‐(1‐pyrrolidinyl)‐cyclohexyl]benzeneacetamide, a specific irreversible ligand for kappa opioid receptors Journal of Labelled Compounds and Radiopharmaceuticals. 28: 1257-1264. DOI: 10.1002/Jlcr.2580281105  0.364
1989 Moody EJ, Mattson M, Newman AH, Rice KC, Skolnick P. Stereospecific reversal of nitrous oxide analgesia by naloxone. Life Sciences. 44: 703-9. PMID 2927240 DOI: 10.1016/0024-3205(89)90381-0  0.56
1989 Schoffelmeer AN, Rice KC, Jacobson AE, Van Gelderen JG, Hogenboom F, Heijna MH, Mulder AH. Mu-, delta- and kappa-opioid receptor-mediated inhibition of neurotransmitter release and adenylate cyclase activity in rat brain slices: studies with fentanyl isothiocyanate. European Journal of Pharmacology. 154: 169-78. PMID 2906610 DOI: 10.1016/0014-2999(88)90094-5  0.418
1989 Rothman RB, Bykov V, Reid A, De Costa BR, Newman AH, Jacobson AE, Rice KC. A brief study of the selectivity of norbinaltorphimine, (-)-cyclofoxy, and (+)-cyclofoxy among opioid receptor subtypes in vitro. Neuropeptides. 12: 181-7. PMID 2853839 DOI: 10.1016/0143-4179(88)90052-2  0.37
1989 Pechnick RN, Wu AA, Chun BM, George R, Thurkauf A, Jacobson AE, Rice KC. Metaphit antagonizes phencyclidine-induced hypothermia in the rat. Life Sciences. 45: 439-445. PMID 2770409 DOI: 10.1016/0024-3205(89)90630-9  0.341
1989 Zimänyi I, Jacobson AE, Rice KC, Lajtha A, Reith MEA. Long-term blockade of the dopamine uptake complex by metaphit, an isothiocyanate derivative of phencyclidine. Synapse. 3: 239-245. PMID 2718099 DOI: 10.1002/Syn.890030310  0.315
1989 Skolnick P, Marvizón JCG, Jackson BW, Monn JA, Rice KC, Lewin AH. Blockade of N-methyl-D-aspartate induced convulsions by 1-aminocyclopropanecarboxylates Life Sciences. 45: 1647-1655. PMID 2685487 DOI: 10.1016/0024-3205(89)90274-9  0.342
1989 Pechnick RN, Wong CA, George R, Thurkauf A, Jacobson AE, Rice KC. Comparison of the effects of the acute administration of dexoxadrol, levoxadrol, MK-801 and phencyclidine on body temperature in the rat. Neuropharmacology. 28: 829-35. PMID 2674766 DOI: 10.1016/0028-3908(89)90175-5  0.373
1989 Schweri MM, Jacobson AE, Lessor RA, Rice KC. Metaphit inhibits dopamine transport and binding of [3H] methylphenidate, a proposed marker for the dopamine transport complex Life Sciences. 45: 1689-1698. PMID 2586226 DOI: 10.1016/0024-3205(89)90279-8  0.338
1989 Rothman RB, Mele A, Reid AA, Akunne H, Greig N, Thurkauf A, Rice KC, Pert A. Tight binding dopamine reuptake inhibitors as cocaine antagonists. A strategy for drug development Febs Letters. 257: 341-344. PMID 2583282 DOI: 10.1016/0014-5793(89)81566-2  0.346
1989 Benkelfat C, Aulakh CS, Bykov V, Rice KC, Costa BRD, Rothman RB. Apparent down-regulation of rat brain μ and κ-opioid binding sites labelled with [3H]cycloFOXY following chronic administration of the potent 5-hydroxytryptamine reuptake blocker, clomipramine Journal of Pharmacy and Pharmacology. 41: 865-867. PMID 2576452 DOI: 10.1111/J.2042-7158.1989.Tb06390.X  0.381
1989 Long JB, Rigamonti DD, de Costa B, Rice KC, Martinez-Arizala A. Dynorphin A-induced rat hindlimb paralysis and spinal cord injury are not altered by the kappa opioid antagonist nor-binaltorphimine. Brain Research. 497: 155-62. PMID 2571391 DOI: 10.1016/0006-8993(89)90982-7  0.337
1989 de Costa BR, Bowen WD, Hellewell SB, Walker JM, Thurkauf A, Jacobson AE, Rice KC. Synthesis and evaluation of optically pure [3H]-(+)-pentazocine, a highly potent and selective radioligand for sigma receptors. Febs Letters. 251: 53-8. PMID 2568952 DOI: 10.1016/0014-5793(89)81427-9  0.336
1989 Rothman RB, Long JB, Holaday JW, Bykov V, de Costa BR, Kim CH, Jacobson AE, Rice KC. A study of the interaction of the alkylating agent, NIH10236, with opioid receptors in vitro and in vivo. Neuropharmacology. 28: 1349-56. PMID 2559348 DOI: 10.1016/0028-3908(89)90009-9  0.352
1989 Nabeshima T, Tohyama K, Noda A, Maeda Y, Hiramatsu M, Harrer SM, Kameyama T, Furukawa H, Jacobson AE, Rice KC. Effects of metaphit on phencyclidine and serotonin2 receptors. Neuroscience Letters. 102: 303-8. PMID 2554211 DOI: 10.1016/0304-3940(89)90096-7  0.356
1989 Rothman RB, France CP, Bykov V, De Costa BR, Jacobson AE, Woods JH, Rice KC. Pharmacological activities of optically pure enantiomers of the kappa opioid agonist, U50,488, and its cis diastereomer: evidence for three kappa receptor subtypes. European Journal of Pharmacology. 167: 345-53. PMID 2553442 DOI: 10.1016/0014-2999(89)90443-3  0.335
1989 de Costa BR, Band L, Rothman RB, Jacobson AE, Bykov V, Pert A, Rice KC. Synthesis of an affinity ligand ('UPHIT') for in vivo acylation of the κ-opioid receptor Febs Letters. 249: 178-182. PMID 2544446 DOI: 10.1016/0014-5793(89)80619-2  0.421
1989 Kim CH, Rothman RB, Jacobson AE, Mattson MV, Bykov V, Streaty RA, Klee WA, George C, Long JB, Rice KC. Probes for narcotic receptor mediated phenomena. 15. (3S,4S)-(+)-trans-3-methylfentanyl isothiocyanate, a potent site-directed acylating agent for the delta opioid receptors in vitro. Journal of Medicinal Chemistry. 32: 1392-8. PMID 2542560 DOI: 10.1021/Jm00126A040  0.38
1989 Bluth LS, Rice KC, Jacobson AE, Bowen WD. Acylation of σ receptors by Metaphit, an isothiocyanate derivative of phencyclidine European Journal of Pharmacology. 161: 273-277. PMID 2542047 DOI: 10.1016/0014-2999(89)90859-5  0.35
1989 Rothman RB, Bykov V, Long JB, Brady LS, Jacobson AE, Rice KC, Holaday JW. Chronic administration of morphine and naltrexone up-regulate mu-opioid binding sites labeled by [3H][D-Ala2,MePhe4,Gly-ol5]enkephalin: further evidence for two mu-binding sites. European Journal of Pharmacology. 160: 71-82. PMID 2540993 DOI: 10.1016/0014-2999(89)90655-9  0.378
1989 McLean S, Rothman RB, Chuang DM, Rice KC, Spain JW, Coscia CJ, Roth BL. Cross-linking of [125I]beta-endorphin to mu-opioid receptors during development. Brain Research. Developmental Brain Research. 45: 283-9. PMID 2540924 DOI: 10.1016/0165-3806(89)90046-1  0.36
1989 McCabe RT, Schoenheimer JA, Skolnick P, Newman AH, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. Febs Letters. 244: 263-7. PMID 2537753 DOI: 10.1016/0014-5793(89)80541-1  0.533
1989 Thurkauf A, Gosta BD, Rice KC. Synthesis of tritium labelled (–)–U50,488, a selective kappa opioid agonist Journal of Labelled Compounds and Radiopharmaceuticals. 27: 577-582. DOI: 10.1002/Jlcr.2580270511  0.332
1988 de Costa BR, George C, Burke TR, Rafferty MF, Contreras PC, Mick SJ, Jacobson AE, Rice KC. Synthesis, configuration, and evaluation of two conformationally restrained analogues of phencyclidine. Journal of Medicinal Chemistry. 31: 1571-5. PMID 3397994 DOI: 10.1021/Jm00403A014  0.321
1988 Sershen H, Berger P, Jacobson AE, Rice KC, Reith ME. Metaphit prevents locomotor activation induced by various psychostimulants and interferes with the dopaminergic system in mice. Neuropharmacology. 27: 23-30. PMID 3352864 DOI: 10.1016/0028-3908(88)90196-7  0.328
1988 Thurkauf A, Mattson MV, Huguenin PN, Rice KC, Jacobson AE. Etoxadrol-meta-isothiocyanate: a potent, enantioselective, electrophilic affinity ligand for the phencyclidine-binding site. Febs Letters. 238: 369-374. PMID 2901991 DOI: 10.1016/0014-5793(88)80514-3  0.341
1988 Danks JA, Tortella FC, Long JB, Bykov V, Jacobson AE, Rice KC, Holaday JW, Rothman RB. Chronic administration of morphine and naltrexone up-regulate[3H][d-ala2,d-leu5]enkephalin binding sites by different mechanisms Neuropharmacology. 27: 965-974. PMID 2847072 DOI: 10.1016/0028-3908(88)90125-6  0.326
1988 Carr DJ, Kim CH, deCosta B, Jacobson AE, Rice KC, Blalock JE. Evidence for a delta-class opioid receptor on cells of the immune system. Cellular Immunology. 116: 44-51. PMID 2844419 DOI: 10.1016/0008-8749(88)90208-0  0.385
1988 Rothman RB, Bykov V, Newman A, Jacobson AE, Rice KC. Interaction of enantiomeric pairs of opiates with phencyclidine binding sites in rat brain: Identification of (+) pentazocine as a ligand potentially suitable for imaging sigma binding sites using positron emission tomography Neuropeptides. 12: 1-5. PMID 2843788 DOI: 10.1016/S0143-4179(98)90002-6  0.384
1988 Bowen WD, Kirschner BK, Newman AH, Rice KC. σ Receptors negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain European Journal of Pharmacology. 149: 399-400. PMID 2842167 DOI: 10.1016/0014-2999(88)90678-4  0.531
1988 Thurkauf A, Hillery P, Mattson MV, Jacobson AE, Rice KC. Synthesis, pharmacological action, and receptor binding affinity of the enantiomeric 1-(1-phenyl-3-methylcyclohexyl)piperidines. Journal of Medicinal Chemistry. 31: 1625-1628. PMID 2840502 DOI: 10.1021/Jm00403A023  0.343
1988 Schoffelmeer ANM, Rice KC, Heijna MH, Hogenboom F, Mulder AH. Fentanyl isothiocyanate reveals the existence of physically associated μ- and δ-opioid receptors mediating inhibition of adenylate cyclase in rat neostriatum European Journal of Pharmacology. 149: 179-182. PMID 2840299 DOI: 10.1016/0014-2999(88)90060-X  0.426
1988 Bolger GT, Skolnick P, Rice KC, Weissman BA. Differential regulation of mu-opiate receptors in heroin- and morphine-dependent rats. Febs Letters. 234: 22-6. PMID 2839362 DOI: 10.1016/0014-5793(88)81294-8  0.413
1988 Rothman RB, Bykov V, Ofri D, Rice KC. LY164929: a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site Neuropeptides. 11: 13-16. PMID 2835701 DOI: 10.1016/0143-4179(88)90022-4  0.322
1988 Rothman RB, Bykov V, Rice KC, Jacobson AE, Kooper GN, Bowen WD. Tritiated-6-beta-fluoro-6-desoxy-oxymorphone ([3H]FOXY): a new ligand and photoaffinity probe for the mu opioid receptors. Neuropeptides. 11: 1-6. PMID 2835700 DOI: 10.1016/0143-4179(88)90020-0  0.366
1988 Bowen WD, Rodrigues PA, Wanzor TE, Jacobson AE, Rice KC. Differential coupling of mu-competitive and mu-noncompetitive delta opiate receptors to guanine nucleotide binding proteins in rat brain membranes. Biochemical Pharmacology. 37: 467-72. PMID 2827687 DOI: 10.1016/0006-2952(88)90216-X  0.341
1987 Schweri MM, Jacobson AE, Lessor RA, Rice KC. Metaphit irreversibly inhibits [3H]threo-(±)-methylphenidate binding to rat striatal tissue Journal of Neurochemistry. 48: 102-105. PMID 3794693 DOI: 10.1111/J.1471-4159.1987.Tb13132.X  0.301
1987 Rothman RB, Long JB, Bykov V, Jacobson AE, Rice KC. Intracerebroventricular administration of superFIT and its enantiomer to rats: Evidence for in vivo acylation of [3H]DADL binding sites Neuropeptides. 9: 207-210. PMID 3037427 DOI: 10.1016/0143-4179(87)90040-0  0.359
1987 Jacobson AE, Rice KC, Burke TR, Lupinacci L, Mattson MV, Aceto MD, Harris LS. 2,5-Dimethyl-2'-hydroxy-9 alpha- and 9 beta-(3-methylbutyl)-6,7-benzomorphans and N-substituted compounds in the 9 alpha-(3-methylbutyl) series: chemistry, pharmacology, and biochemistry. Journal of Pharmaceutical Sciences. 76: 248-52. PMID 3035172 DOI: 10.1002/Jps.2600760315  0.365
1987 Awaya H, May EL, Aceto MD, Harris LS, Silverton JV, Rice KC, Mattson MV, Jacobson AE. Hexahydro-1H-1-pyrindines from acid rearrangement of 9-alkylidene-5-(m-methoxyphenyl)-2-methylmorphans. A new structural type of narcotic antagonists. Journal of Medicinal Chemistry. 30: 947-50. PMID 3033248 DOI: 10.1021/Jm00388A037  0.556
1987 Ostrowski NL, Burke TR, Rice KC, Pert A, Pert CB. The pattern of [3H]cyclofoxy retention in rat brain after in vivo injection corresponds to the in vitro opiate receptor distribution. Brain Research. 402: 275-86. PMID 3030494 DOI: 10.1016/0006-8993(87)90034-5  0.335
1987 McLean S, Rothman RB, Jacobson AE, Rice KC, Herkenham M. Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamster. The Journal of Comparative Neurology. 255: 497-510. PMID 2880880 DOI: 10.1002/Cne.902550403  0.35
1987 Tamminga CA, Tanimoto K, Kuo S, Chase TN, Contreras PC, Rice KC, Jackson AE, O'Donohue TL. PCP-induced alterations in cerebral glucose utilization in rat brain: blockade by metaphit, a PCP-receptor-acylating agent. Synapse (New York, N.Y.). 1: 497-504. PMID 2850626 DOI: 10.1002/Syn.890010514  0.31
1987 Rothman RB, Jacobson AE, Rice KC, Herkenham M. Autoradiographic evidence for two classes of mu opioid binding sites in rat brain using [125I]FK33824. Peptides. 8: 1015-21. PMID 2831515 DOI: 10.1016/0196-9781(87)90130-6  0.324
1987 Snell LD, Johnson KM, Yi SJ, Lessor RA, Rice KC, Jacobson AE. Phencyclidine (PCP)-like inhibition of N-methyl-D-aspartate-evoked striatal acetylcholine release, H-TCP binding and synaptosomal dopamine uptake by metaphit, a proposed PCP receptor acylator. Life Sciences. 41: 2645-2654. PMID 2826948 DOI: 10.1016/0024-3205(87)90279-7  0.357
1987 Carr DJJ, DeCosta B, Jacobson AE, Bost KL, Rice KC, Blalock JE. Immunoaffinity-purified opiate receptor specifically binds the δ-class opiate receptor ligand, cis-(+)-3-methylfentanylisothiocyanate, SUPERFIT Febs Letters. 224: 272-276. PMID 2826227 DOI: 10.1016/0014-5793(87)80468-4  0.343
1987 Tocque B, Jacobson AE, Rice KC, Frey EA. The μ-opioid receptor in the 7315c tumor cell European Journal of Pharmacology. 143: 127-130. PMID 2826184 DOI: 10.1016/0014-2999(87)90742-4  0.397
1987 Rothman RB, McLean S, Bykov V, Lessor RA, Jacobson AE, Rice KC, Holaday JW. Chronic morphine upregulates a μ-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography European Journal of Pharmacology. 142: 73-81. PMID 2826178 DOI: 10.1016/0014-2999(87)90655-8  0.392
1987 DeCosta B, George C, Rothman RB, Jacobson AE, Rice KC. Synthesis and absolute configuration of optically pure enantiomers of a ϰ‐opioid receptor selective agonist Febs Letters. 223: 335-339. PMID 2822490 DOI: 10.1016/0014-5793(87)80315-0  0.374
1987 Newman AH, Lueddens HWM, Skolnick P, Rice KC. Novel irreversible ligands specific for "peripheral" type benzodiazepine receptors: (±)-, (+)-, and (-)-1-(2-chlorophenyl)-N-(1-methylpropyl)-N-(2-isothiocyanatoethyl)-3- isoquinolinecarboxamide and 1-(2-isothiocyanatoethyl)-7-chloro-1,3-dihydro-5-(4-chlorophenyl)-2H-1,4- benzodiazepin-2-one Journal of Medicinal Chemistry. 30: 1901-1905. PMID 2821259 DOI: 10.1021/Jm00393A036  0.558
1987 French ED, Jacobson AE, Rice KC. Metaphit, a proposed phencyclidine (PCP) antagonist, prevents PCP-induced locomotor behavior through mechanisms unrelated to specific blockade of PCP receptors European Journal of Pharmacology. 140: 267-274. PMID 2820762 DOI: 10.1016/0014-2999(87)90283-4  0.396
1986 Berger P, Jacobsen AE, Rice KC, Lessor RA, Reith MA. Metaphit, a receptor acylator, inactivates cocaine binding sites in striatum and antagonizes cocaine-induced locomotor stimulation in rodents. Neuropharmacology. 25: 931-3. PMID 3774118 DOI: 10.1016/0028-3908(86)90023-7  0.34
1986 Dumont R, Newman AH, Rice KC, Brossi A, Toome V, Wegrzynski B. Precursors of the mammalian synthesis of morphine: (+)-salutaridine and (-)-thebaine from (+)-6-demethylsalutaridine, and (-)-N-13CH3-thebaine from (-)-northebaine. Febs Letters. 206: 125-9. PMID 3758343 DOI: 10.1016/0014-5793(86)81353-9  0.492
1986 Donnerer J, Oka K, Brossi A, Rice KC, Spector S. Presence and formation of codeine and morphine in the rat Proceedings of the National Academy of Sciences of the United States of America. 83: 4566-4567. PMID 3459191 DOI: 10.1073/Pnas.83.12.4566  0.339
1986 Wang Y, Palmer M, Freedman R, Hoffer B, Mattson MV, Lessor RA, Rice KC, Jacobson AE. Antagonism of phencyclidine action by metaphit in rat cerebellar Purkinje neurons: an electrophysiological study. Proceedings of the National Academy of Sciences of the United States of America. 83: 2724-7. PMID 3458231 DOI: 10.1073/Pnas.83.8.2724  0.3
1986 Lessor RA, Bajwa BS, Rice KC, Jacobson AE, Streaty RA, Klee WA, Smith CB, Aceto MD, May EL, Harris LS. Probes for narcotic receptor mediated phenomena. 13. Potential irreversible narcotic antagonist-based ligands derived from 6,14-endo-ethenotetrahydronororipavine with 7-(methoxyfumaroyl)amino, (bromoacetyl)amino, or isothiocyanate electrophiles: chemistry, biochemistry, and pharmacology. Journal of Medicinal Chemistry. 29: 2136-41. PMID 3023609 DOI: 10.1021/Jm00161A002  0.613
1986 Herkenham M, Rice KC, Jacobson AE, Rothman RB. Opiate receptors in rat pituitary are confined to the neural lobe and are exclusively kappa. Brain Research. 382: 365-71. PMID 3019482 DOI: 10.1016/0006-8993(86)91346-6  0.373
1986 Davies SN, Church J, Blake J, Lodge D, Lessor RA, Rice KC, Jacobson AE. Is Metaphit a phencyclidine antagonist? Studies with ketamine, phencyclidine and N-methylaspartate. Life Sciences. 38: 2441-5. PMID 3014248 DOI: 10.1016/0024-3205(86)90614-4  0.348
1986 Rothman RB, Danks JA, Jacobson AE, Burke TR, Rice KC, Tortella FC, Holaday JW. Morphine tolerance increases μ-noncompetative δ binding sites European Journal of Pharmacology. 124: 113-119. PMID 3013657 DOI: 10.1016/0014-2999(86)90130-5  0.385
1986 Burke TR, Jacobson AE, Rice KC, Silverton JV, Simonds WF, Streaty RA, Klee WA. Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for delta opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity. Journal of Medicinal Chemistry. 29: 1087-1093. PMID 3012085 DOI: 10.1021/Jm00156A030  0.413
1986 Burke TR, Jacobson AE, Rice KC, Weissman BA, Huang HC, Silverton JV. Probes for narcotic receptor mediated phenomena. 9. Synthesis of (±)-(3α,6aα,11aβ)-1,3,4,5,6,11a-hexahydro-2-methyl-2H-3, 6a-methanobenzofuro[2,3-c]azocin-10-ol, an oxide-bridged 5-(m-hydroxyphenyl)morphan Journal of Medicinal Chemistry. 29: 748-751. PMID 3009813 DOI: 10.1002/Chin.198638301  0.338
1986 Contreras PC, Rice KC, Jacobson AE, O'Donohue TL. Stereotyped behavior correlates better than ataxia with phencyclidine-receptor interactions European Journal of Pharmacology. 121: 9-18. PMID 3007170 DOI: 10.1016/0014-2999(86)90386-9  0.38
1986 Bolger GT, Rafferty MF, Weissman BA, Rice KC, Skolnick P. Acylating phencyclidines irreversibly enhance brain calcium antagonist binding. Pharmacology, Biochemistry, and Behavior. 25: 51-7. PMID 2944131 DOI: 10.1016/0091-3057(86)90229-7  0.318
1985 Schweri MM, Skolnick P, Rafferty MF, Rice KC, Janowsky AJ, Paul SM. [3H]Threo-(+/-)-methylphenidate binding to 3,4-dihydroxyphenylethylamine uptake sites in corpus striatum: correlation with the stimulant properties of ritalinic acid esters. Journal of Neurochemistry. 45: 1062-70. PMID 4031878 DOI: 10.1111/J.1471-4159.1985.Tb05524.X  0.311
1985 Rothman RB, Bykov V, Danks JA, Jacobson AE, Burke TR, Rice KC, Herkenham M. Preparation of rat brain membranes highly enriched with opiate kappa binding sites using site-directed acylating agents: optimization of assay conditions. Neuropeptides. 6: 503-16. PMID 3001575 DOI: 10.1016/0143-4179(85)90112-X  0.303
1985 Rothman RB, Danks JA, Jacobson AE, Burke TR, Rice KC. Leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to the opiate mu-recognition site: evidence for delta----mu binding site interactions in vitro. Neuropeptides. 6: 351-363. PMID 2995865 DOI: 10.1016/0143-4179(85)90008-3  0.305
1985 Goldman ME, Jacobson AE, Rice KC, Paul SM. Differentiation of [3H]phencyclidine and ( + )-[3H]SKF-10,047 binding sites in rat cerebral cortex Febs Letters. 190: 333-336. PMID 2995139 DOI: 10.1016/0014-5793(85)81313-2  0.371
1985 Portoghese PS, Larson DL, Yim CB, Sayre LM, Ronsisvalle G, Lipkowski AW, Takemori AE, Rice KC, Tam SW. Stereostructure-activity relationship of opioid agonist and antagonist bivalent ligands. Evidence for bridging between vicinal opioid receptors. Journal of Medicinal Chemistry. 28: 1140-1. PMID 2993609 DOI: 10.1002/Chin.198551348  0.397
1985 Simonds WF, Burke TR, Rice KC, Jacobson AE, Klee WA. Purification of the opiate receptor of NG108-15 neuroblastoma-glioma hybrid cells. Proceedings of the National Academy of Sciences of the United States of America. 82: 4974-4978. PMID 2991902 DOI: 10.1073/Pnas.82.15.4974  0.303
1985 Rothman RB, Danks JA, Herkenham M, Jacobson AE, Burke TR, Rice KC. Evidence that the delta-selective alkylating agent, fit, alters the mu-noncompetitive opiate delta binding site. Neuropeptides. 6: 227-37. PMID 2991807 DOI: 10.1016/0143-4179(85)90093-9  0.303
1985 Contreras PC, Rafferty MF, Lessor RA, Rice KC, Jacobson AE, O'Donohue TL. A specific alkylating ligand for phencyclidine (PCP) receptors antagonizes PCP behavioral effects. European Journal of Pharmacology. 111: 405-6. PMID 2990961 DOI: 10.1016/0014-2999(85)90652-1  0.339
1985 Lutz RA, Costa T, Cruciani RA, Jacobson AE, Rice KC, Burke TR, Krumins SA, Rodbard D. Increased affinity of dimeric enkephalins is not dependent on receptor density. Neuropeptides. 6: 167-74. PMID 2987746 DOI: 10.1016/0143-4179(85)90107-6  0.315
1985 Rafferty MF, Mattson M, Jacobson AE, Rice KC. A specific acylating agent for the [3H]phencyclidine receptors in rat brain Febs Letters. 181: 318-322. PMID 2982662 DOI: 10.1016/0014-5793(85)80284-2  0.354
1985 Creveling CR, McNeal ET, Lewandowski GA, Rafferty M, Harrison EH, Jacobson AE, Rice KC, Daly JW. Local anesthetic properties of opioids and phencyclidines: interaction with the voltage-dependent, batrachotoxin binding site in sodium channels. Neuropeptides. 5: 253-6. PMID 2582303 DOI: 10.1016/0143-4179(85)90026-5  0.324
1984 Rothman RB, Danks JA, Jacobson AE, Burke TR, Rice KC, Pert CB. Tritiated-6-beta-fluoro-6-desoxy-oxymorphone: a highly selective ligand for the opiate mu receptor whose binding is characterized by low nonspecific binding. Neuropeptides. 4: 311-7. PMID 6206435 DOI: 10.1016/0143-4179(84)90005-2  0.349
1984 Lessor RA, Rice KC, Streaty RA, Klee WA, Jacobson AE. Probes for narcotic receptor mediated phenomena. 10. Irreversible ligands to opioid receptors based on biologically potent endoethenooripavines. Reversible binding of fit to mu and delta opioid receptors. Neuropeptides. 5: 229-232. PMID 6152321 DOI: 10.1016/0143-4179(84)90069-6  0.421
1984 Burke TR, Bajwa BS, Jacobson AE, Rice KC, Streaty RA, Klee WA. Probes for narcotic receptor mediated phenomena. 7. Synthesis and pharmacological properties of irreversible ligands specific for mu or delta opiate receptors. Journal of Medicinal Chemistry. 27: 1570-1574. PMID 6150112 DOI: 10.1021/Jm00378A008  0.421
1984 Pert CB, Danks JA, Channing MA, Eckelman WC, Larson SM, Bennett JM, Burke TR, Rice KC. 3-[18F]Acetylcyclofoxy: a useful probe for the visualization of opiate receptors in living animals. Febs Letters. 177: 281-6. PMID 6094248 DOI: 10.1016/0014-5793(84)81300-9  0.327
1984 Rothman RB, Danks JA, Pert CB, Jacobson AE, Burke TR, Rice KC. Ionic conditions differentially affect 3H-DADL binding to type-I and type-II opiate delta receptors in vitro. Neuropeptides. 4: 261-8. PMID 6087192 DOI: 10.1016/0143-4179(84)90108-2  0.301
1984 Rothman RB, Pert CB, Jacobson AE, Burke TR, Rice KC. Morphine noncompetitively inhibits [3H]leucine enkephalin binding to membranes lacking type-II delta binding sites: evidence for a two-site allosteric model. Neuropeptides. 4: 257-60. PMID 6087191 DOI: 10.1016/0143-4179(84)90107-0  0.317
1984 Rothman RB, Bowen WD, Bykov V, Schumacher UK, Pert CB, Jacobson AE, Burke TR, Rice KC. Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: evidence for a two-site allosteric model. Neuropeptides. 4: 201-15. PMID 6087189 DOI: 10.1016/0143-4179(84)90101-X  0.325
1984 Burke TR, Rice KC, Jacobson AE, Simonds WF, Klee WA. Probes for narcotic receptor mediated phenomena 8. Tritiation of irreversible mu or delta specific opioid receptor affinity ligands to high specific activity Journal of Labelled Compounds and Radiopharmaceuticals. 21: 693-702. DOI: 10.1002/Jlcr.2580210802  0.393
1983 Lozovsky D, Saller CF, Bayorh MA, Chiueh CC, Rice KC, Burke TR, Kopin IJ. Effects of phencyclidine on rat prolactin, dopamine receptor and locomotor activity. Life Sciences. 32: 2725-31. PMID 6855468 DOI: 10.1016/0024-3205(83)90392-2  0.343
1983 Jacobson AE, Bajwa BS, Streaty RA, Klee WA, Rice KC. Probes for narcotic receptor mediated phenomena. 5. Narcotic antagonist irreversible ligands based on endoethenotetrahydrooripavine Life Sciences. 33: 159-162. PMID 6319854 DOI: 10.1016/0024-3205(83)90468-X  0.408
1983 Rice KC, Jacobson AE, Burke TR, Bajwa BS, Streaty RA, Klee WA. Irreversible ligands with high selectivity toward delta and mu opiate receptors Science. 220: 314-316. PMID 6132444 DOI: 10.1126/Science.6132444  0.384
1983 CAIN M, WEBER RW, GUZMAN F, COOK JM, BARKER SA, RICE KC, CRAWLEY JN, PAUL SM, SKOLNICK P. ChemInform Abstract: β-CARBOLINES: SYNTHESIS AND NEUROCHEMICAL AND PHARMACOLOGICAL ACTIONS ON BRAIN BENZODIAZEPINE RECEPTORS Chemischer Informationsdienst. 14. DOI: 10.1002/Chin.198305238  0.306
1982 Rehavi M, Ittah Y, Skolnick P, Rice KC, Paul SM. Nitroimipramines - Synthesis and pharmacological effects of potent long-acting inhibitors of [3H] serotonin uptake and [3H] imipramine binding Naunyn-Schmiedeberg's Archives of Pharmacology. 320: 45-49. PMID 7121610 DOI: 10.1007/Bf00499070  0.308
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