Jun-Xu Li - Publications

Affiliations: 
State University of New York, Buffalo, Buffalo, NY, United States 
Area:
Behavioral Pharmacology

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Year Citation  Score
2023 Siemian JN, Woodhouse K, Liu DH, Zhang Y, Li JX. The imidazoline I receptor agonist 2-BFI reduces abuse-related effects of morphine: self-administration and drug discrimination. Psychopharmacology. PMID 38159161 DOI: 10.1007/s00213-023-06524-2  0.826
2023 Liu J, Wu R, Li JX. TAAR1 as an emerging target for the treatment of psychiatric disorders. Pharmacology & Therapeutics. 108580. PMID 38142862 DOI: 10.1016/j.pharmthera.2023.108580  0.739
2022 Zhang D, Decker AM, Woodhouse K, Snyder R, Patel P, Harris DL, Tao YX, Li JX, Zhang Y. Isoquinolone derivatives as lysophosphatidic acid receptor 5 (LPA5) antagonists: Investigation of structure-activity relationships, ADME properties and analgesic effects. European Journal of Medicinal Chemistry. 243: 114741. PMID 36126387 DOI: 10.1016/j.ejmech.2022.114741  0.806
2022 Mitra S, Thomas SA, Martin JA, Williams J, Woodhouse K, Chandra R, Li JX, Lobo MK, Sim FJ, Dietz DM. EGR3 regulates opioid-related nociception and motivation in male rats. Psychopharmacology. PMID 36098762 DOI: 10.1007/s00213-022-06226-1  0.788
2022 Liu J, Wu R, Johnson B, Zhang Y, Zhu Q, Li JX. Selective TAAR1 agonists induce conditioned taste aversion. Psychopharmacology. PMID 36056214 DOI: 10.1007/s00213-022-06222-5  0.773
2022 Liu J, Li JX, Wu R. Toll-Like Receptor 4: A Novel Target to Tackle Drug Addiction? Handbook of Experimental Pharmacology. PMID 35434747 DOI: 10.1007/164_2022_586  0.752
2022 Liu J, Wu R, Seaman R, Manz KM, Johnson B, Vu J, Huang Y, Zhang Y, Robison AJ, Neve R, Grueter BA, Dietz D, Li JX. TAAR1 regulates drug-induced reinstatement of cocaine-seeking via negatively modulating CaMKIIα activity in the NAc. Molecular Psychiatry. PMID 35079125 DOI: 10.1038/s41380-022-01448-3  0.762
2021 Wu R, Liu J, Li JX. Trace amine-associated receptor 1 and drug abuse. Advances in Pharmacology (San Diego, Calif.). 93: 373-401. PMID 35341572 DOI: 10.1016/bs.apha.2021.10.005  0.778
2021 Wu R, Liu J, Vu J, Huang Y, Dietz DM, Li JX. Interleukin-1 receptor-associated kinase 4 (IRAK4) in the nucleus accumbens regulates opioid-seeking behavior in male rats. Brain, Behavior, and Immunity. PMID 34958862 DOI: 10.1016/j.bbi.2021.12.014  0.794
2021 Nguyen T, Gamage TF, Finlay DB, Decker AM, Langston TL, Barrus D, Glass M, Li JX, Kenakin TP, Zhang Y. Development of 3-(4-Chlorophenyl)-1-(phenethyl)urea Analogues as Allosteric Modulators of the Cannabinoid Type-1 Receptor: RTICBM-189 is Brain Penetrant and Attenuates Reinstatement of Cocaine-Seeking Behavior. Journal of Medicinal Chemistry. PMID 34929081 DOI: 10.1021/acs.jmedchem.1c01432  0.325
2021 Wu R, Li JX. Potential of Ligands for Trace Amine-Associated Receptor 1 (TAAR1) in the Management of Substance Use Disorders. Cns Drugs. 35: 1239-1248. PMID 34766253 DOI: 10.1007/s40263-021-00871-4  0.739
2021 Wu R, Liu J, Seaman R, Johnson B, Zhang Y, Li JX. The selective TAAR1 partial agonist RO5263397 promoted novelty recognition memory in mice. Psychopharmacology. PMID 34291306 DOI: 10.1007/s00213-021-05937-1  0.773
2021 Wu R, Liu J, Johnson B, Huang Y, Zhang Y, Li JX. Activation of trace amine-associated receptor 1 attenuates nicotine withdrawal-related effects. Addiction Biology. e13075. PMID 34170054 DOI: 10.1111/adb.13075  0.773
2021 Wu R, Liu J, Johnson B, Huang Y, Zhang Y, Li JX. Activation of trace amine-associated receptor 1 attenuates nicotine withdrawal-related effects. Addiction Biology. e13075. PMID 34170054 DOI: 10.1111/adb.13075  0.773
2020 Wu R, Li JX. Toll-Like Receptor 4 Signaling and Drug Addiction. Frontiers in Pharmacology. 11: 603445. PMID 33424612 DOI: 10.3389/fphar.2020.603445  0.738
2020 Lewter LA, Golani LK, Cook JM, Li JX. Blockade of α1 subtype GABAA receptors attenuates the development of tolerance to the antinociceptive effects of midazolam in rats. Behavioural Pharmacology. PMID 33290344 DOI: 10.1097/FBP.0000000000000614  0.824
2020 Liu J, Seaman R, Johnson B, Wu R, Vu J, Tian J, Zhang Y, Li JX. Activation of Trace Amine-Associated Receptor 1 Selectively Attenuates the Reinforcing Effects of Morphine. British Journal of Pharmacology. PMID 33247948 DOI: 10.1111/bph.15335  0.793
2020 Nguyen T, Marusich J, Li JX, Zhang Y. Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. Journal of Medicinal Chemistry. PMID 32673481 DOI: 10.1021/Acs.Jmedchem.0C00643  0.505
2020 Wu R, Liu J, Wang K, Huang Y, Zhang Y, Li JX. Effects of A Trace Amine-Associated Receptor 1 Agonist RO 5263397 on Ethanol-induced Behavioral Sensitization. Behavioural Brain Research. 112641. PMID 32407821 DOI: 10.1016/J.Bbr.2020.112641  0.76
2020 Liu J, Johnson B, Wu R, Seaman R, Vu J, Zhu Q, Zhang Y, Li JX. TAAR 1 Agonists Attenuate Extended Access Cocaine Self-administration and Yohimbine-induced Reinstatement of Cocaine-seeking. British Journal of Pharmacology. PMID 32246467 DOI: 10.1111/Bph.15061  0.754
2020 Liu J, Wu R, Li JX. TAAR1 and Psychostimulant Addiction. Cellular and Molecular Neurobiology. PMID 31974906 DOI: 10.1007/S10571-020-00792-8  0.809
2020 Bousquet P, Hudson A, García-Sevilla JA, Li JX. Imidazoline Receptor System: The Past, the Present, and the Future. Pharmacological Reviews. 72: 50-79. PMID 31819014 DOI: 10.1124/Pr.118.016311  0.489
2019 Liu J, Wu R, Johnson B, Vu J, Bass C, Li JX. The Claustrum-Prefrontal Cortex Pathway Regulates Impulsive-like Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31704786 DOI: 10.1523/Jneurosci.1005-19.2019  0.731
2019 Nguyen T, Gamage T, Decker AM, Barrus D, Langston TL, Li JX, Thomas BF, Zhang Y. Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators. Journal of Medicinal Chemistry. PMID 31596583 DOI: 10.1021/Acs.Jmedchem.9B01161  0.429
2019 Martin JA, Werner CT, Mitra S, Zhong P, Wang ZJ, Gobira PH, Stewart AF, Zhang J, Erias K, Siemian JN, Hagarty D, Mueller LE, Neve RL, Li JX, Chandra R, et al. A novel role for the actin-binding protein drebrin in regulating opiate addiction. Nature Communications. 10: 4140. PMID 31515501 DOI: 10.1038/S41467-019-12122-8  0.732
2019 Li JX. Combining opioids and non-opioids for pain management: Current status. Neuropharmacology. PMID 31029588 DOI: 10.1016/J.Neuropharm.2019.04.025  0.461
2019 Liu JF, Wu R, Li JX. Toll of Mental Disorders: TLR-Mediated Function of the Innate Immune System. Neuroscience Bulletin. PMID 30628028 DOI: 10.1007/S12264-018-00335-8  0.701
2019 Wu R, Liu J, Vu J, Johnson B, Li J. The Role of interleukin‐1 receptor‐associated kinase 4 in drug addiction The Faseb Journal. 33. DOI: 10.1096/Fasebj.2019.33.1_Supplement.663.1  0.417
2018 Xue Z, Siemian JN, Zhu Q, Blough BE, Li JX. Further pharmacological comparison of D-methamphetamine and L-methamphetamine in rats: abuse-related behavioral and physiological indices. Behavioural Pharmacology. PMID 30480551 DOI: 10.1097/Fbp.0000000000000453  0.719
2018 Siemian JN, Shang L, Seaman RW, Zhu Q, Zhang Y, Li JX. Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats. Behavioural Pharmacology. PMID 30383551 DOI: 10.1097/Fbp.0000000000000454  0.794
2018 Liu JF, Li JX. Drug addiction: a curable mental disorder? Acta Pharmacologica Sinica. PMID 30382181 DOI: 10.1038/S41401-018-0180-X  0.469
2018 Werner CT, Viswanathan R, Martin JA, Gobira PH, Mitra S, Thomas SA, Wang ZJ, Liu JF, Stewart AF, Neve RL, Li JX, Gancarz AM, Dietz DM. E3 Ubiquitin-Protein Ligase SMURF1 in the Nucleus Accumbens Mediates Cocaine Seeking. Biological Psychiatry. PMID 30158054 DOI: 10.1016/J.Biopsych.2018.07.013  0.461
2018 Liu JF, Tian J, Li JX. Modulating reconsolidation and extinction to regulate drug reward memory. The European Journal of Neuroscience. PMID 30113098 DOI: 10.1111/Ejn.14072  0.459
2018 Liu JF, Li JX. TAAR1 in Addiction: Looking Beyond the Tip of the Iceberg. Frontiers in Pharmacology. 9: 279. PMID 29636691 DOI: 10.3389/Fphar.2018.00279  0.566
2018 Siemian JN, Jia S, Liu JF, Zhang Y, Li JX. Neuroanatomical characterization of imidazoline Ireceptor agonist-induced antinociception. The European Journal of Neuroscience. PMID 29514408 DOI: 10.1111/Ejn.13899  0.807
2018 Liu JF, Seaman R, Siemian JN, Bhimani R, Johnson B, Zhang Y, Zhu Q, Hoener MC, Park J, Dietz DM, Li JX. Role of trace amine-associated receptor 1 in nicotine's behavioral and neurochemical effects. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29472642 DOI: 10.1038/S41386-018-0017-9  0.757
2018 Siemian JN, Wang K, Zhang Y, Li JX. Mechanisms of imidazoline Ireceptor agonist-induced antinociception in rats: involvement of monoaminergic neurotransmission. British Journal of Pharmacology. PMID 29451703 DOI: 10.1111/Bph.14161  0.793
2018 Ou Y, Su M, Ling Y, Wei Q, Pan F, Li J, Li JX, Zhu Q. Anti-allodynic effects of N-demethylsinomenine, an active metabolite of sinomenine, in a mouse model of postoperative pain. European Journal of Pharmacology. 823: 105-109. PMID 29408089 DOI: 10.1016/J.Ejphar.2018.01.044  0.362
2018 Siemian JN, LaMacchia ZM, Spreuer V, Tian J, Ignatowski TA, Paez PM, Zhang Y, Li JX. The imidazoline I2 receptor agonist 2-BFI attenuates hypersensitivity and spinal neuroinflammation in a rat model of neuropathic pain. Biochemical Pharmacology. PMID 29366977 DOI: 10.1016/J.Bcp.2018.01.032  0.755
2017 Perrey DA, Li JX, Zhang Y. Modified synthesis of NOP receptor antagonist SB612111. Synthesis. 49: 1394-1400. PMID 31571700 DOI: 10.1055/S-0036-1588379  0.331
2017 Bernosky-Smith KA, Qiu YY, Feja M, Lee YB, Loughlin B, Li JX, Bass CE. Ventral tegmental area D2 receptor knockdown enhances choice impulsivity in a delay-discounting task in rats. Behavioural Brain Research. 341: 129-134. PMID 29287910 DOI: 10.1016/J.Bbr.2017.12.029  0.557
2017 Xue Z, Siemian JN, Johnson BN, Zhang Y, Li JX. Methamphetamine-induced impulsivity during chronic methamphetamine treatment in rats: Effects of the TAAR 1 agonist RO5263397. Neuropharmacology. PMID 29128305 DOI: 10.1016/J.Neuropharm.2017.11.012  0.762
2017 Siemian JN, Qiu Y, Zhang Y, Li JX. Role of intracellular Ca(2+) signaling in the antinociceptive and discriminative stimulus effects of the imidazoline I2 receptor agonist 2-BFI in rats. Psychopharmacology. PMID 28825118 DOI: 10.1007/S00213-017-4719-1  0.812
2017 Nguyen T, German N, Decker AM, Langston TL, Gamage TF, Farquhar CE, Li JX, Wiley JL, Thomas BF, Zhang Y. Novel Diarylurea Based Allosteric Modulators of the Cannabinoid CB1 Receptor: Evaluation of Importance of 6-Pyrrolidinylpyridinyl Substitution. Journal of Medicinal Chemistry. PMID 28792219 DOI: 10.1021/Acs.Jmedchem.7B00707  0.471
2017 Nguyen T, Decker AM, Langston TL, Mathews KM, Siemian JN, Li JX, Harris DL, Runyon SP, Zhang Y. Discovery of Novel Proline-Based Neuropeptide FF Receptor Antagonists. Acs Chemical Neuroscience. PMID 28737888 DOI: 10.1021/Acschemneuro.7B00219  0.78
2017 Siemian JN, Zhang Y, Li JX. Trace amine-associated receptor 1 agonists RO5263397 and RO5166017 attenuate quinpirole-induced yawning but not hypothermia in rats. Behavioural Pharmacology. PMID 28704278 DOI: 10.1097/Fbp.0000000000000330  0.783
2017 Witkin JM, Cerne R, Wakulchik M, S J, Gleason SD, Jones TM, Li G, Arnold LA, Li JX, Schkeryantz JM, Methuku KR, Cook JM, Poe MM. Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors. Pharmacology, Biochemistry, and Behavior. PMID 28442369 DOI: 10.1016/J.Pbb.2017.04.009  0.406
2017 Siemian JN, Xue Z, Blough BE, Li JX. Comparison of some behavioral effects of d- and l-methamphetamine in adult male rats. Psychopharmacology. PMID 28386698 DOI: 10.1007/S00213-017-4623-8  0.702
2017 Li JX. Imidazoline I2 receptors: An update. Pharmacology & Therapeutics. PMID 28322973 DOI: 10.1016/J.Pharmthera.2017.03.009  0.476
2017 Thorn DA, Zhang Y, Li JX. Tolerance and cross-tolerance to the antinociceptive effects of oxycodone and the imidazoline I2 receptor agonist phenyzoline in adult male rats. Psychopharmacology. PMID 28314949 DOI: 10.1007/S00213-017-4599-4  0.764
2017 Lewter LA, Fisher JL, Siemian JN, Methuku KR, Poe MM, Cook JM, Li JX. Antinociceptive effects of a novel α2/α3-subtype selective GABAA receptor positive allosteric modulator. Acs Chemical Neuroscience. PMID 28150939 DOI: 10.1021/Acschemneuro.6B00447  0.778
2017 Liu JF, Siemian JN, Seaman R, Zhang Y, Li JX. Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-Seeking Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 37: 882-892. PMID 28123023 DOI: 10.1523/JNEUROSCI.2006-16.2017  0.764
2016 Liu JF, Siemian JN, Seaman R, Zhang Y, Li JX. Role of TAAR1 within the Subregions of the Mesocorticolimbic Dopaminergic System in Cocaine-seeking Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27980118 DOI: 10.1523/Jneurosci.2006-16.2017  0.776
2016 Nguyen T, Li JX, Thomas BF, Wiley JL, Kenakin TP, Zhang Y. Allosteric Modulation: An Alternate Approach Targeting the Cannabinoid CB1 Receptor. Medicinal Research Reviews. PMID 27879006 DOI: 10.1002/Med.21418  0.372
2016 Li JX. Buprenorphine analogue BU08028 is one step closer to the Holy Grail of opioid research. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573851 DOI: 10.1073/Pnas.1612752113  0.428
2016 Wang ZJ, Martin JA, Mueller LE, Caccamise A, Werner CT, Neve RL, Gancarz AM, Li JX, Dietz DM. BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior. Biological Psychiatry. PMID 27422367 DOI: 10.1016/J.Biopsych.2016.04.020  0.363
2016 Thorn DA, Li J, Qiu Y, Li JX. Agmatine attenuates the discriminative stimulus and hyperthermic effects of methamphetamine in male rats. Behavioural Pharmacology. PMID 27232669 DOI: 10.1097/Fbp.0000000000000244  0.783
2016 Siemian JN, Obeng S, Zhang Y, Zhang Y, Li JX. Antinociceptive interactions between the imidazoline I2 receptor agonist 2-BFI and opioids in rats: role of efficacy at the μ opioid receptor. The Journal of Pharmacology and Experimental Therapeutics. PMID 27056847 DOI: 10.1124/Jpet.116.232421  0.801
2016 Zhu Q, Sun Y, Mao L, Liu C, Jiang B, Zhang W, Li JX. Antinociceptive effects of sinomenine in a rat model of postoperative pain. British Journal of Pharmacology. PMID 26915970 DOI: 10.1111/Bph.13470  0.341
2016 Liu JF, Thorn DA, Zhang Y, Li JX. Effects of Trace Amine-associated Receptor 1 Agonists on the Expression, Reconsolidation, and Extinction of Cocaine Reward Memory. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 26822713 DOI: 10.1093/Ijnp/Pyw009  0.784
2016 Thorn DA, Zhang Y, Li JX. Effects of the imidazoline I2 receptor agonist 2-BFI on the development of tolerance and behavioral/physical dependence to morphine in rats. British Journal of Pharmacology. PMID 26776953 DOI: 10.1111/Bph.13435  0.784
2016 Zhu Q, Mao LN, Liu CP, Sun YH, Jiang B, Zhang W, Li JX. Antinociceptive effects of vitexin in a mouse model of postoperative pain. Scientific Reports. 6: 19266. PMID 26763934 DOI: 10.1038/Srep19266  0.447
2016 Qin WJ, Wang YT, Li PM, Wang XX, Li JX, Noori HR, Bernardi RE, Liang JH, Zhang XL. Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. Psychopharmacology. PMID 26728895 DOI: 10.1007/S00213-015-4197-2  0.594
2015 Grandy DK, Miller GM, Li JX. "TAARgeting Addiction"-The Alamo Bears Witness to Another Revolution: An Overview of the Plenary Symposium of the 2015 Behavior, Biology and Chemistry Conference. Drug and Alcohol Dependence. PMID 26644139 DOI: 10.1016/J.Drugalcdep.2015.11.014  0.339
2015 Siemian JN, Li J, Zhang Y, Li JX. Interactions between imidazoline I2 receptor ligands and acetaminophen in adult male rats: antinociception and schedule-controlled responding. Psychopharmacology. PMID 26613734 DOI: 10.1007/S00213-015-4166-9  0.788
2015 Thorn DA, Qiu Y, Jia S, Zhang Y, Li JX. Antinociceptive effects of imidazoline I2 receptor agonists in the formalin test in rats. Behavioural Pharmacology. PMID 26599907 DOI: 10.1097/Fbp.0000000000000206  0.815
2015 Perrey DA, Decker AM, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y. The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Bioorganic & Medicinal Chemistry. PMID 26216017 DOI: 10.1016/J.Bmc.2015.07.013  0.432
2015 Jing L, Li JX. Trace amine-associated receptor 1: A promising target for the treatment of psychostimulant addiction. European Journal of Pharmacology. 761: 345-352. PMID 26092759 DOI: 10.1016/J.Ejphar.2015.06.019  0.606
2015 Thorn DA, Siemian JN, Zhang Y, Li JX. Anti-hyperalgesic effects of imidazoline I2 receptor ligands in a rat model of inflammatory pain: interactions with oxycodone. Psychopharmacology. PMID 26037946 DOI: 10.1007/S00213-015-3983-1  0.825
2015 Abiraman K, Pol SU, O'Bara MA, Chen GD, Khaku ZM, Wang J, Thorn D, Vedia BH, Ekwegbalu EC, Li JX, Salvi RJ, Sim FJ. Anti-muscarinic adjunct therapy accelerates functional human oligodendrocyte repair. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3676-88. PMID 25716865 DOI: 10.1523/Jneurosci.3510-14.2015  0.716
2015 Perrey DA, German NA, Decker AM, Thorn D, Li JX, Gilmour BP, Thomas BF, Harris DL, Runyon SP, Zhang Y. Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor. Acs Chemical Neuroscience. 6: 599-614. PMID 25643283 DOI: 10.1016/J.Drugalcdep.2015.07.659  0.759
2015 Qiu Y, Zhang Y, Li JX. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. European Journal of Pharmacology. 749: 133-41. PMID 25617792 DOI: 10.1016/J.Ejphar.2015.01.013  0.638
2015 Jing L, Zhang Y, Li JX. Effects of the trace amine associated receptor 1 agonist RO5263397 on abuse-related behavioral indices of methamphetamine in rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25522401 DOI: 10.1093/Ijnp/Pyu060  0.659
2015 Li J, Jing L, Zhang Y. Effects of the trace amine associated receptor 1 agonist RO5263397 on behavioral indices of methamphetamine in rats Drug and Alcohol Dependence. 156: e127-e128. DOI: 10.1016/J.Drugalcdep.2015.07.351  0.628
2015 Li J, Thorn DA, Jing L, Zhang Y. The trace-amine-associated receptor 1 agonist RO5263397 attenuates abuse-related effects of cocaine in rats Drug and Alcohol Dependence. 146: e177-e178. DOI: 10.1016/J.Drugalcdep.2014.09.399  0.795
2014 Zhu Q, Sun Y, Zhu J, Fang T, Zhang W, Li JX. Antinociceptive effects of sinomenine in a rat model of neuropathic pain. Scientific Reports. 4: 7270. PMID 25434829 DOI: 10.1038/Srep07270  0.407
2014 Ding Y, Qiu Y, Jing L, Thorn DA, Zhang Y, Li JX. Behavioral effects of the cannabinoid CB1 receptor allosteric modulator ORG27569 in rats. Pharmacology Research & Perspectives. 2: e00069. PMID 25431655 DOI: 10.1002/Prp2.69  0.834
2014 Qiu Y, He XH, Zhang Y, Li JX. Discriminative stimulus effects of the novel imidazoline I₂ receptor ligand CR4056 in rats. Scientific Reports. 4: 6605. PMID 25308382 DOI: 10.1038/Srep06605  0.637
2014 Jing L, Qiu Y, Zhang Y, Li JX. Effects of the cannabinoid CB₁ receptor allosteric modulator ORG 27569 on reinstatement of cocaine- and methamphetamine-seeking behavior in rats. Drug and Alcohol Dependence. 143: 251-6. PMID 25169627 DOI: 10.1016/J.Drugalcdep.2014.08.004  0.718
2014 Li YL, Liu Q, Gong Q, Li JX, Wei SP, Wang YT, Liang H, Zhang M, Jing L, Yong Z, Lawrence AJ, Liang JH. Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats. Acta Pharmacologica Sinica. 35: 853-61. PMID 24909512 DOI: 10.1038/Aps.2014.28  0.646
2014 Zhang C, Flowers E, Li JX, Wang Q, Sun W. Loudness perception affected by high doses of salicylate--a behavioral model of hyperacusis. Behavioural Brain Research. 271: 16-22. PMID 24882611 DOI: 10.1016/J.Bbr.2014.05.045  0.34
2014 Li JX. Trace amines and cocaine abuse. Acs Chemical Neuroscience. 5: 497-8. PMID 24849494 DOI: 10.1021/Cn500104S  0.383
2014 Zhu Q, Sun Y, Yun X, Ou Y, Zhang W, Li JX. Antinociceptive effects of curcumin in a rat model of postoperative pain. Scientific Reports. 4: 4932. PMID 24816565 DOI: 10.1038/Srep04932  0.334
2014 Thorn DA, Jing L, Qiu Y, Gancarz-Kausch AM, Galuska CM, Dietz DM, Zhang Y, Li JX. Effects of the trace amine-associated receptor 1 agonist RO5263397 on abuse-related effects of cocaine in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2309-16. PMID 24743376 DOI: 10.1038/Npp.2014.91  0.784
2014 Thorn DA, Zhang C, Zhang Y, Li JX. The trace amine associated receptor 1 agonist RO5263397 attenuates the induction of cocaine behavioral sensitization in rats. Neuroscience Letters. 566: 67-71. PMID 24561093 DOI: 10.1016/J.Neulet.2014.02.024  0.769
2014 Qiu Y, Thorn DA, Zhang Y, He X, Li JX. Behavioral effects of the imidazoline I(2) receptor ligand BU99006 in rats. Behavioural Pharmacology. 25: 130-6. PMID 24518265 DOI: 10.1097/Fbp.0000000000000028  0.814
2014 Jing L, Zhang M, Li JX, Huang P, Liu Q, Li YL, Liang H, Liang JH. Comparison of single versus repeated methamphetamine injection induced behavioral sensitization in mice. Neuroscience Letters. 560: 103-6. PMID 24361545 DOI: 10.1016/J.Neulet.2013.12.024  0.659
2014 Li JX, Thorn DA, Qiu Y, Peng BW, Zhang Y. Antihyperalgesic effects of imidazoline I(2) receptor ligands in rat models of inflammatory and neuropathic pain. British Journal of Pharmacology. 171: 1580-90. PMID 24329196 DOI: 10.1111/Bph.12555  0.8
2014 Zhang Y, Perrey D, German N, Gilmour B, Li J, Thomas B. Development of selective orexin-1 receptor antagonists Drug and Alcohol Dependence. 140: e249-e250. DOI: 10.1016/J.Drugalcdep.2014.02.690  0.441
2014 Li J, Thorn D. Agmatine modifies some behavioral effects of methamphetamine in rats Drug and Alcohol Dependence. 140: e121-e122. DOI: 10.1016/J.Drugalcdep.2014.02.347  0.717
2013 Min JW, Peng BW, He X, Zhang Y, Li JX. Gender difference in epileptogenic effects of 2-BFI and BU224 in mice. European Journal of Pharmacology. 718: 81-6. PMID 24055191 DOI: 10.1016/J.Ejphar.2013.09.016  0.449
2013 Perrey DA, German NA, Gilmour BP, Li JX, Harris DL, Thomas BF, Zhang Y. Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor. Journal of Medicinal Chemistry. 56: 6901-16. PMID 23941044 DOI: 10.1021/Jm400720H  0.461
2013 Li JX, Thorn DA, Jin C. The GPR88 receptor agonist 2-PCCA does not alter the behavioral effects of methamphetamine in rats. European Journal of Pharmacology. 698: 272-7. PMID 23123351 DOI: 10.1016/J.Ejphar.2012.10.037  0.79
2013 Li JX, Shah AP, Patel SK, Rice KC, France CP. Modification of the behavioral effects of morphine in rats by serotonin 5-HT₁A and 5-HTâ‚‚A receptor agonists: antinociception, drug discrimination, and locomotor activity. Psychopharmacology. 225: 791-801. PMID 22993050 DOI: 10.1007/S00213-012-2870-2  0.59
2013 Maguire DR, Li JX, Koek W, France CP. Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys. Psychopharmacology. 225: 173-85. PMID 22836370 DOI: 10.1007/S00213-012-2803-0  0.622
2012 Li JX, Koek W, France CP. Interactions between Δ(9)-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys. Behavioural Pharmacology. 23: 754-61. PMID 23044830 DOI: 10.1097/Fbp.0B013E32835A3907  0.604
2012 Maguire DR, Li JX, France CP. Impulsivity and drugs of abuse: a juice-reinforced operant procedure for determining within-session delay discounting functions in rhesus monkeys. Journal of Pharmacological and Toxicological Methods. 66: 264-9. PMID 22944347 DOI: 10.1016/j.vascn.2012.08.168  0.531
2012 Zhang M, Jing L, Liu Q, Wen RT, Li JX, Li YL, Gong Q, Liang JH. Tramadol induces conditioned place preference in rats: interactions with morphine and buprenorphine. Neuroscience Letters. 520: 87-91. PMID 22626615 DOI: 10.1016/J.Neulet.2012.05.037  0.715
2012 Liu Q, Zhang M, Qin WJ, Wang YT, Li YL, Jing L, Li JX, Lawrence AJ, Liang JH. Septal nuclei critically mediate the development of behavioral sensitization to a single morphine injection in rats. Brain Research. 1454: 90-9. PMID 22502977 DOI: 10.1016/J.Brainres.2012.03.027  0.684
2012 An XF, Zhang Y, Winter JC, Li JX. Effects of imidazoline I(2) receptor agonists and morphine on schedule-controlled responding in rats. Pharmacology, Biochemistry, and Behavior. 101: 354-9. PMID 22330673 DOI: 10.1016/J.Pbb.2012.01.024  0.536
2012 Thorn DA, Winter JC, Li JX. Agmatine attenuates methamphetamine-induced conditioned place preference in rats. European Journal of Pharmacology. 680: 69-72. PMID 22329899 DOI: 10.1016/J.Ejphar.2012.01.037  0.769
2012 Thorn DA, An XF, Zhang Y, Pigini M, Li JX. Characterization of the hypothermic effects of imidazoline Iâ‚‚ receptor agonists in rats. British Journal of Pharmacology. 166: 1936-45. PMID 22324428 DOI: 10.1111/J.1476-5381.2012.01894.X  0.784
2012 Li JX, Zhang Y. Emerging drug targets for pain treatment. European Journal of Pharmacology. 681: 1-5. PMID 22314220 DOI: 10.1016/J.Ejphar.2012.01.017  0.406
2012 Sampson C, Zhang Y, Del Bello F, Li JX. Effects of imidazoline I2 receptor ligands on acute nociception in rats. Neuroreport. 23: 73-7. PMID 22107843 DOI: 10.1097/Wnr.0B013E32834E7Db3  0.551
2011 Li JX, Ju S, Baladi MG, Koek W, France CP. Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction. Behavioural Pharmacology. 22: 751-7. PMID 21979831 DOI: 10.1097/Fbp.0B013E32834D0Eeb  0.762
2011 Thorn DA, Zhang Y, Peng BW, Winter JC, Li JX. Effects of imidazoline Iâ‚‚ receptor ligands on morphine- and tramadol-induced antinociception in rats. European Journal of Pharmacology. 670: 435-40. PMID 21970802 DOI: 10.1016/J.Ejphar.2011.09.173  0.786
2011 Li JX, Zhang Y, Winter JC. Morphine-induced antinociception in the rat: supra-additive interactions with imidazoline Iâ‚‚ receptor ligands. European Journal of Pharmacology. 669: 59-65. PMID 21867697 DOI: 10.1016/J.Ejphar.2011.07.041  0.542
2011 Li JX, Zhang Y. Imidazoline I2 receptors: target for new analgesics? European Journal of Pharmacology. 658: 49-56. PMID 21371460 DOI: 10.1016/J.Ejphar.2011.02.038  0.496
2011 Li JX, Koek W, Rice KC, France CP. Effects of direct- and indirect-acting serotonin receptor agonists on the antinociceptive and discriminative stimulus effects of morphine in rhesus monkeys. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 940-9. PMID 21209613 DOI: 10.1038/Npp.2010.232  0.582
2011 Li JX, Crocker C, Koek W, Rice KC, France CP. Effects of serotonin (5-HT)1A and 5-HT2A receptor agonists on schedule-controlled responding in rats: drug combination studies. Psychopharmacology. 213: 489-97. PMID 21174080 DOI: 10.1007/S00213-010-2136-9  0.559
2011 Li JX, Gerak LR, France CP. Drug Discrimination Studies in Rhesus Monkeys: Drug Dependence and Withdrawal Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies. 417-430. DOI: 10.1002/9781118023150.ch13  0.684
2010 Li X, Li JX, France CP. Interactions between morphine, scopolamine and nicotine: schedule-controlled responding in rats. Pharmacology, Biochemistry, and Behavior. 96: 91-5. PMID 20420849 DOI: 10.1016/j.pbb.2010.04.011  0.605
2010 Becker GL, Gerak LR, Li JX, Koek W, France CP. Precipitated and conditioned withdrawal in morphine-treated rats. Psychopharmacology. 209: 85-94. PMID 20127077 DOI: 10.1007/S00213-009-1773-3  0.727
2010 Li JX, Koek W, Rice KC, France CP. Differential effects of serotonin 5-HT1A receptor agonists on the discriminative stimulus effects of the 5-HT2A receptor agonist 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rats and rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 333: 244-52. PMID 20053932 DOI: 10.1124/Jpet.109.163451  0.576
2010 Li X, Li JX, Zhu X, Cui R, Jiao J. Effects of physostigmine on the conditioned hyperactivity and locomotor sensitization to morphine in rats. Behavioural Brain Research. 206: 223-8. PMID 19761800 DOI: 10.1016/J.Bbr.2009.09.016  0.398
2009 Li JX, Unzeitig A, Javors MA, Rice KC, Koek W, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), ketanserin, and (R)-(+)-{alpha}-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-pipidinemethanol (MDL100907) in rats. The Journal of Pharmacology and Experimental Therapeutics. 331: 671-9. PMID 19687292 DOI: 10.1124/Jpet.109.157560  0.538
2009 France CP, Li JX, Owens WA, Koek W, Toney GM, Daws LC. Reduced effectiveness of escitalopram in the forced swimming test is associated with increased serotonin clearance rate in food-restricted rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 731-6. PMID 19419596 DOI: 10.1017/S1461145709000418  0.471
2009 Li JX, Koek W, France CP. Food restriction and streptozotocin differentially modify sensitivity to the hypothermic effects of direct- and indirect-acting serotonin receptor agonists in rats. European Journal of Pharmacology. 613: 60-3. PMID 19379724 DOI: 10.1016/J.Ejphar.2009.04.027  0.514
2009 Li JX, Rice KC, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys: antagonism and apparent pA2 analyses. The Journal of Pharmacology and Experimental Therapeutics. 328: 976-81. PMID 19098164 DOI: 10.1124/Jpet.108.145458  0.545
2009 May JA, Sharif NA, Chen HH, Liao JC, Kelly CR, Glennon RA, Young R, Li JX, Rice KC, France CP. Pharmacological properties and discriminative stimulus effects of a novel and selective 5-HT2 receptor agonist AL-38022A [(S)-2-(8,9-dihydro-7H-pyrano[2,3-g]indazol-1-yl)-1-methylethylamine]. Pharmacology, Biochemistry, and Behavior. 91: 307-14. PMID 18718483 DOI: 10.1016/J.Pbb.2008.07.015  0.515
2009 McMahon LR, Li JX, Carroll FI, France CP. Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys. Psychopharmacology. 203: 411-20. PMID 18636243 DOI: 10.1007/S00213-008-1242-4  0.74
2008 Li JX, France CP. Food restriction and streptozotocin treatment decrease 5-HT1A and 5-HT2A receptor-mediated behavioral effects in rats. Behavioural Pharmacology. 19: 292-7. PMID 18622176 DOI: 10.1097/FBP.0b013e328308f1d6  0.538
2008 Li JX, McMahon LR, Gerak LR, Becker GL, France CP. Interactions between Delta(9)-tetrahydrocannabinol and mu opioid receptor agonists in rhesus monkeys: discrimination and antinociception. Psychopharmacology. 199: 199-208. PMID 18470505 DOI: 10.1007/S00213-008-1157-0  0.805
2008 Li JX, Rice KC, France CP. Discriminative stimulus effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 324: 827-33. PMID 17993605 DOI: 10.1124/Jpet.107.130625  0.579
2008 Li JX, McMahon LR, France CP. Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys. Psychopharmacology. 195: 479-86. PMID 17874317 DOI: 10.1007/S00213-007-0914-9  0.714
2008 France CP, Unzeitig A, Javors MA, Rice KC, Li J. IS THERE BEHAVIORAL EVIDENCE FOR CONSTITUTIVE ACTIVITY AT 5-HT2ARECEPTORS? Alcoholism: Clinical and Experimental Research. 32: 367A-367A. DOI: 10.1111/J.1530-0277.2008.00689_2.X  0.48
2008 McMahon LR, Li JX, Carroll FI, France CP. Some effects of dopamine transporter and receptor ligands on discriminative stimulus, physiologic, and directly observable indices of opioid withdrawal in rhesus monkeys (Psychopharmacology DOI: 10.1007/s00213-008-1242-4) Psychopharmacology. 200: 611. DOI: 10.1007/S00213-008-1298-1  0.718
2007 Li JX, Rice KC, France CP. Behavioral effects of dipropyltryptamine in rats: evidence for 5-HT1A and 5-HT2A agonist activity. Behavioural Pharmacology. 18: 283-8. PMID 17551320 DOI: 10.1097/Fbp.0B013E3281F19Ca0  0.631
2007 Li JX, Becker GL, Traynor JR, Gong ZH, France CP. Thienorphine: receptor binding and behavioral effects in rhesus monkeys. The Journal of Pharmacology and Experimental Therapeutics. 321: 227-36. PMID 17220427 DOI: 10.1124/jpet.106.113290  0.614
2005 Li JX, Han R, Deng YP, Chen SQ, Liang JH. Different effects of valproate on methamphetamine- and cocaine-induced behavioral sensitization in mice. Behavioural Brain Research. 161: 125-32. PMID 15904719 DOI: 10.1016/J.Bbr.2005.01.015  0.586
2004 Li JX, Zhao WL, Liang JH. Effects of carbamazepine on morphine-induced behavioral sensitization in mice. Brain Research. 1019: 77-83. PMID 15306241 DOI: 10.1016/J.Brainres.2004.05.082  0.612
2004 Li JX, Zhang Q, Liang JH. Valproate prevents the induction, but not the expression of morphine sensitization in mice. Behavioural Brain Research. 152: 251-7. PMID 15196792 DOI: 10.1016/J.Bbr.2003.10.006  0.608
2004 Liang JH, Li JX, Wang XH, Chen B, Lu Y, Zhang P, Han R, Ye XF. L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice. Acta Pharmacologica Sinica. 25: 644-50. PMID 15132832  0.505
2003 Zhang Q, Li JX, Zheng JW, Liu RK, Liang JH. L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice. European Journal of Pharmacology. 467: 145-50. PMID 12706468 DOI: 10.1016/S0014-2999(03)01567-X  0.575
Low-probability matches (unlikely to be authored by this person)
2013 Li JX. The application of conditioning paradigms in the measurement of pain. European Journal of Pharmacology. 716: 158-68. PMID 23500202 DOI: 10.1016/J.Ejphar.2013.03.002  0.27
2020 Woodhouse KL, Cook JM, Li J. Evaluating Combination Therapies for Treatment of Chronic Inflammatory Pain: a GABA A Approach The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05190  0.261
2016 He M, Min JW, Kong WL, He XH, Li JX, Peng BW. A review on the pharmacological effects of vitexin and isovitexin. Fitoterapia. PMID 27693342 DOI: 10.1016/J.Fitote.2016.09.011  0.261
2018 Luo HB, Shang N, Xie WZ, Wen DJ, Qu M, Huang S, Fan SS, Chen W, Mou NQ, Liu XY, Chen Q, Xie FF, Li JX. maxim extract attenuates abnormal Tau phosphorylation. Neural Regeneration Research. 13: 915-922. PMID 29863023 DOI: 10.4103/1673-5374.232487  0.261
2015 Li JX. Pain and depression comorbidity: a preclinical perspective. Behavioural Brain Research. 276: 92-8. PMID 24797835 DOI: 10.1016/J.Bbr.2014.04.042  0.258
2023 Pauly RC, Bhimani RV, Li JX, Blough BE, Landavazo A, Park J. Distinct Effects of Methamphetamine Isomers on Limbic Norepinephrine and Dopamine Transmission in the Rat Brain. Acs Chemical Neuroscience. PMID 36976755 DOI: 10.1021/acschemneuro.2c00689  0.251
2018 Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, et al. CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination. Molecular Psychiatry. PMID 30413800 DOI: 10.1038/S41380-018-0285-0  0.248
2018 Jiang B, Wang H, Wang JL, Wang YJ, Zhu Q, Wang CN, Song L, Gao TT, Wang Y, Zhu WZ, Meng GL, Wu F, Huang C, Ling Y, Zhang W, ... Li JX, et al. Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway. Biological Psychiatry. PMID 30503507 DOI: 10.1016/J.Biopsych.2018.10.004  0.246
2019 Zhang Y, Huang R, Cheng M, Wang L, Chao J, Li J, Zheng P, Xie P, Zhang Z, Yao H. Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2. Microbiome. 7: 116. PMID 31439031 DOI: 10.1186/S40168-019-0733-3  0.236
2015 Nguyen T, German N, Decker AM, Li JX, Wiley JL, Thomas BF, Kenakin TP, Zhang Y. Structure-activity relationships of substituted 1H-indole-2-carboxamides as CB1 receptor allosteric modulators. Bioorganic & Medicinal Chemistry. 23: 2195-203. PMID 25797163 DOI: 10.1016/J.Bmc.2015.02.058  0.211
2016 Li J. Activation of TAAR1 reduces cocaine addiction: from behavior to neurobiology Intrinsic Activity. 4: A3.2. DOI: 10.25006/IA.4.S2-A3.2  0.208
2014 Kong WL, Min JW, Liu YL, Li JX, He XH, Peng BW. Role of TRPV1 in susceptibility to PTZ-induced seizure following repeated hyperthermia challenges in neonatal mice. Epilepsy & Behavior : E&B. 31: 276-80. PMID 24269027 DOI: 10.1016/J.Yebeh.2013.10.022  0.198
2023 Qian X, Zhao X, Yu L, Yin Y, Zhang XD, Wang L, Li JX, Zhu Q, Luo JL. Current status of GABA receptor subtypes in analgesia. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 168: 115800. PMID 37935070 DOI: 10.1016/j.biopha.2023.115800  0.198
2020 Zhang Y, Du L, Bai Y, Han B, He C, Gong L, Huang R, Shen L, Chao J, Liu P, Zhang H, Zhang H, Gu L, Li J, Hu G, et al. Co-localization of circDYM with miR-9 in microglia. Molecular Psychiatry. 25: 1155. PMID 32444805 DOI: 10.1038/S41380-020-0780-Y  0.171
2022 Zheng MC, Tang WT, Yu LL, Qian XJ, Ren J, Li JJ, Rong WW, Li JX, Zhu Q. Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration. Molecules (Basel, Switzerland). 27. PMID 35684506 DOI: 10.3390/molecules27113570  0.152
2023 Yu L, Qian X, Feng Y, Yin Y, Zhang XD, Wei Q, Wang L, Rong W, Li JJ, Li JX, Zhu Q. Investigation of preclinical pharmacokinetics of -demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method. Frontiers in Chemistry. 11: 1222560. PMID 37483270 DOI: 10.3389/fchem.2023.1222560  0.135
2000 Rausch J, Fei Y, Li J, Shendarkar N, Hobby H, Ganapathy V, Leibach F. 306. SERT genotype influence in fluoxetine antidepressant response: a study of initial conditions Biological Psychiatry. 47: S92-S93. DOI: 10.1016/S0006-3223(00)00570-9  0.077
2011 Peng BW, Justice JA, Zhang K, Li JX, He XH, Sanchez RM. Gabapentin promotes inhibition by enhancing hyperpolarization-activated cation currents and spontaneous firing in hippocampal CA1 interneurons. Neuroscience Letters. 494: 19-23. PMID 21352896 DOI: 10.1016/J.Neulet.2011.02.045  0.073
1998 Rausch J, Fei Y, Li J, Ganapathy V, Hobby H, Shendarkar N, Leibach F. 242. Sert promoter region deletion and alcoholism risk Biological Psychiatry. 43: S72. DOI: 10.1016/S0006-3223(98)90690-4  0.038
2014 Baccei M, Li J. (356) Neonatal injury facilitates synaptic plasticity in adult spinal nociceptive circuits The Journal of Pain. 15: S65. DOI: 10.1016/j.jpain.2014.01.266  0.015
2022 Li JX. Preface. Advances in Pharmacology (San Diego, Calif.). 93: xiii-xiv. PMID 35341575 DOI: 10.1016/S1054-3589(22)00014-X  0.01
2009 Gu Y, Wang Y, Li J, Martin OJF, Gong Q. Interplay of plasmon resonances in binary nanostructures Applied Physics B. 98: 353-363. DOI: 10.1007/S00340-009-3824-1  0.01
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