David G. Nicholls - Publications

Affiliations: 
Biochemistry University of Dundee, Dundee, Scotland, United Kingdom 

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Year Citation  Score
2015 Gerencser AA, Mulder H, Nicholls DG. Calcium modulation of exocytosis-linked plasma membrane potential oscillations in INS-1 832/13 cells. The Biochemical Journal. 471: 111-22. PMID 26243883 DOI: 10.1042/BJ20150616  0.366
2012 Goehring I, Gerencser AA, Schmidt S, Brand MD, Mulder H, Nicholls DG. Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics. The Journal of Biological Chemistry. 287: 15706-17. PMID 22418435 DOI: 10.1074/Jbc.M111.314567  0.305
2009 Nicholls DG. Mitochondrial calcium function and dysfunction in the central nervous system. Biochimica Et Biophysica Acta. 1787: 1416-24. PMID 19298790 DOI: 10.1016/j.bbabio.2009.03.010  0.345
2008 Brookes PS, Parker N, Buckingham JA, Vidal-Puig A, Halestrap AP, Gunter TE, Nicholls DG, Bernardi P, Lemasters JJ, Brand MD. UCPs--unlikely calcium porters. Nature Cell Biology. 10: 1235-7; author reply. PMID 18978830 DOI: 10.1038/Ncb1108-1235  0.325
2006 Oliveira JM, Chen S, Almeida S, Riley R, Gonçalves J, Oliveira CR, Hayden MR, Nicholls DG, Ellerby LM, Rego AC. Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11174-86. PMID 17065457 DOI: 10.1523/Jneurosci.3004-06.2006  0.342
2005 Nicholls DG. Mitochondria and calcium signaling. Cell Calcium. 38: 311-7. PMID 16087232 DOI: 10.1016/j.ceca.2005.06.011  0.389
2004 Nicholls DG, Chalmers S. The integration of mitochondrial calcium transport and storage. Journal of Bioenergetics and Biomembranes. 36: 277-81. PMID 15377857 DOI: 10.1023/B:Jobb.0000041753.52832.F3  0.338
2004 Vesce S, Kirk L, Nicholls DG. Relationships between superoxide levels and delayed calcium deregulation in cultured cerebellar granule cells exposed continuously to glutamate. Journal of Neurochemistry. 90: 683-93. PMID 15255947 DOI: 10.1111/j.1471-4159.2004.02516.x  0.357
2003 Nicholls DG, Vesce S, Kirk L, Chalmers S. Interactions between mitochondrial bioenergetics and cytoplasmic calcium in cultured cerebellar granule cells. Cell Calcium. 34: 407-24. PMID 12909085 DOI: 10.1016/S0143-4160(03)00144-1  0.338
2001 Rego AC, Ward MW, Nicholls DG. Mitochondria control ampa/kainate receptor-induced cytoplasmic calcium deregulation in rat cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1893-901. PMID 11245674  0.358
2000 Ward MW, Rego AC, Frenguelli BG, Nicholls DG. Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7208-19. PMID 11007877  0.406
1999 del Río E, McLaughlin M, Downes CP, Nicholls DG. Differential coupling of G-protein-linked receptors to Ca2+ mobilization through inositol(1,4,5)trisphosphate or ryanodine receptors in cerebellar granule cells in primary culture. The European Journal of Neuroscience. 11: 3015-22. PMID 10510166 DOI: 10.1046/j.1460-9568.1999.00714.x  0.422
1999 Castilho RF, Ward MW, Nicholls DG. Oxidative stress, mitochondrial function, and acute glutamate excitotoxicity in cultured cerebellar granule cells. Journal of Neurochemistry. 72: 1394-401. PMID 10098841 DOI: 10.1046/j.1471-4159.1999.721394.x  0.372
1999 Cousin MA, McLaughlin M, Nicholls DG. Protein kinase C modulates field-evoked transmitter release from cultured rat cerebellar granule cells via a dendrotoxin-sensitive K+ channel. The European Journal of Neuroscience. 11: 101-9. PMID 9987015 DOI: 10.1046/j.1460-9568.1999.00412.x  0.611
1998 Nicholls DG, Budd SL. Neuronal excitotoxicity: the role of mitochondria. Biofactors (Oxford, England). 8: 287-99. PMID 9914831 DOI: 10.1002/BIOF.5520080317  0.303
1998 Castilho RF, Hansson O, Ward MW, Budd SL, Nicholls DG. Mitochondrial control of acute glutamate excitotoxicity in cultured cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 10277-86. PMID 9852565  0.402
1998 Pocock JM, Nicholls DG. Exocytotic and nonexocytotic modes of glutamate release from cultured cerebellar granule cells during chemical ischaemia. Journal of Neurochemistry. 70: 806-13. PMID 9453577 DOI: 10.1046/J.1471-4159.1998.70020806.X  0.436
1997 Cousin MA, Nicholls DG. Synaptic vesicle recycling in cultured cerebellar granule cells: role of vesicular acidification and refilling. Journal of Neurochemistry. 69: 1927-35. PMID 9349537  0.535
1997 Cousin MA, Hurst H, Nicholls DG. Presynaptic calcium channels and field-evoked transmitter exocytosis from cultured cerebellar granule cells. Neuroscience. 81: 151-61. PMID 9300408 DOI: 10.1016/S0306-4522(97)00047-X  0.617
1996 Budd SL, Nicholls DG. Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. Journal of Neurochemistry. 67: 2282-91. PMID 8931459 DOI: 10.1046/J.1471-4159.1996.67062282.X  0.393
1996 Cousin MA, Hurst H, Held B, Nicholls DG. Transmitter exocytosis in cultured cerebellar granule cells stimulated with an applied electrical field. Biochemical Society Transactions. 24: 430S. PMID 8878974  0.507
1996 Budd DC, May GR, Nicholls DG, McCormack JG. Inhibition by lifarizine of intracellular Ca2+ rises and glutamate exocytosis in depolarized rat cerebrocortical synaptosomes and cultured neurones. British Journal of Pharmacology. 118: 162-6. PMID 8733590 DOI: 10.1111/j.1476-5381.1996.tb15380.x  0.437
1996 Tibbs GR, Dolly JO, Nicholls DG. Evidence for the induction of repetitive action potentials in synaptosomes by K+-channel inhibitors: an analysis of plasma membrane ion fluxes. Journal of Neurochemistry. 67: 389-97. PMID 8667018 DOI: 10.1046/J.1471-4159.1996.67010389.X  0.314
1996 Budd SL, Nicholls DG. A reevaluation of the role of mitochondria in neuronal Ca2+ homeostasis. Journal of Neurochemistry. 66: 403-11. PMID 8522981 DOI: 10.1046/J.1471-4159.1996.66010403.X  0.414
1995 Cousin MA, Held B, Nicholls DG. Exocytosis and selective neurite calcium responses in rat cerebellar granule cells during field stimulation. The European Journal of Neuroscience. 7: 2379-88. PMID 8845942 DOI: 10.1111/j.1460-9568.1995.tb01035.x  0.626
1995 Cousin MA, Pocock JM, Nicholls DG. Intracellular free Ca2+ responses in electrically stimulated cerebellar granule cells. Biochemical Society Transactions. 23: 648-52. PMID 8566435  0.579
1995 Vázquez E, Budd DC, Herrero I, Nicholls DG, Sánchez-Prieto J. Co-existence and interaction between facilitatory and inhibitory metabotropic glutamate receptors and the inhibitory adenosine A1 receptor in cerebrocortical nerve terminals. Neuropharmacology. 34: 919-27. PMID 8532173 DOI: 10.1016/0028-3908(95)00067-G  0.309
1995 Pocock JM, Cousin MA, Parkin J, Nicholls DG. Glutamate exocytosis from cerebellar granule cells: the mechanism of a transition to an L-type Ca2+ channel coupling. Neuroscience. 67: 595-607. PMID 7675189 DOI: 10.1016/0306-4522(95)00061-M  0.632
1995 Cousin MA, Nicholls DG, Pocock JM. Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain. Journal of Neurochemistry. 64: 2097-104. PMID 7536807  0.642
1994 del Río E, Nicholls DG, Downes CP. Involvement of calcium influx in muscarinic cholinergic regulation of phospholipase C in cerebellar granule cells. Journal of Neurochemistry. 63: 535-43. PMID 8035177 DOI: 10.1046/J.1471-4159.1994.63020535.X  0.402
1994 Coffey ET, Sihra TS, Nicholls DG, Pocock JM. Phosphorylation of synapsin I and MARCKS in nerve terminals is mediated by Ca2+ entry via an Aga-GI sensitive Ca2+ channel which is coupled to glutamate exocytosis. Febs Letters. 353: 264-8. PMID 7957871 DOI: 10.1016/0014-5793(94)01061-7  0.38
1994 Coffey ET, Herrero I, Sihra TS, Sánchez-Prieto J, Nicholls DG. Glutamate exocytosis and MARCKS phosphorylation are enhanced by a metabotropic glutamate receptor coupled to a protein kinase C synergistically activated by diacylglycerol and arachidonic acid. Journal of Neurochemistry. 63: 1303-10. PMID 7931282 DOI: 10.1046/J.1471-4159.1994.63041303.X  0.31
1993 Pocock JM, Cousin MA, Nicholls DG. The calcium channel coupled to the exocytosis of L-glutamate from cerebellar granule cells is inhibited by the spider toxin, Aga-GI. Neuropharmacology. 32: 1185-94. PMID 8107972 DOI: 10.1016/0028-3908(93)90012-R  0.606
1993 Coffey ET, Sihra TS, Nicholls DG. Protein kinase C and the regulation of glutamate exocytosis from cerebrocortical synaptosomes. The Journal of Biological Chemistry. 268: 21060-5. PMID 8104937  0.362
1993 McMahon HT, Nicholls DG. Barium-evoked glutamate release from guinea-pig cerebrocortical synaptosomes. Journal of Neurochemistry. 61: 110-5. PMID 8099947 DOI: 10.1111/j.1471-4159.1993.tb03543.x  0.412
1993 Cousin MA, Nicholls DG, Pocock JM. Flunarizine inhibits both calcium-dependent and -independent release of glutamate from synaptosomes and cultured neurones. Brain Research. 606: 227-36. PMID 8098253 DOI: 10.1016/0006-8993(93)90989-Z  0.634
1993 Barrie AP, Nicholls DG. Adenosine A1 receptor inhibition of glutamate exocytosis and protein kinase C-mediated decoupling. Journal of Neurochemistry. 60: 1081-6. PMID 8094742 DOI: 10.1111/j.1471-4159.1993.tb03257.x  0.344
1992 Courtney MJ, Nicholls DG. Interactions between phospholipase C-coupled and N-methyl-D-aspartate receptors in cultured cerebellar granule cells: protein kinase C mediated inhibition of N-methyl-D-aspartate responses. Journal of Neurochemistry. 59: 983-92. PMID 1386623 DOI: 10.1111/j.1471-4159.1992.tb08339.x  0.315
1992 McMahon HT, Foran P, Dolly JO, Verhage M, Wiegant VM, Nicholls DG. Tetanus toxin and botulinum toxins type A and B inhibit glutamate, gamma-aminobutyric acid, aspartate, and met-enkephalin release from synaptosomes. Clues to the locus of action. The Journal of Biological Chemistry. 267: 21338-43. PMID 1356988  0.329
1992 Pocock JM, Nicholls DG. A toxin (Aga-GI) from the venom of the spider Agelenopsis aperta inhibits the mammalian presynaptic Ca2+ channel coupled to glutamate exocytosis. European Journal of Pharmacology. 226: 343-50. PMID 1356813 DOI: 10.1016/0922-4106(92)90052-W  0.429
1992 Sihra TS, Bogonez E, Nicholls DG. Localized Ca2+ entry preferentially effects protein dephosphorylation, phosphorylation, and glutamate release. The Journal of Biological Chemistry. 267: 1983-9. PMID 1309806  0.382
1992 Nicholls DG. Is all Ca2+-dependent release vesicular and is all Ca2+-independent release cytoplasmic? Neurochemistry International. 21: W3. DOI: 10.1016/0197-0186(92)91870-3  0.358
1991 Verhage M, McMahon HT, Ghijsen WE, Boomsma F, Scholten G, Wiegant VM, Nicholls DG. Differential release of amino acids, neuropeptides, and catecholamines from isolated nerve terminals. Neuron. 6: 517-24. PMID 2015091 DOI: 10.1016/0896-6273(91)90054-4  0.378
1991 Barrie AP, Nicholls DG, Sanchez-Prieto J, Sihra TS. An ion channel locus for the protein kinase C potentiation of transmitter glutamate release from guinea pig cerebrocortical synaptosomes. Journal of Neurochemistry. 57: 1398-404. PMID 1716664 DOI: 10.1111/j.1471-4159.1991.tb08306.x  0.365
1991 Verhage M, Ghijsen WE, Nicholls DG, Wiegant VM. Characterization of the release of cholecystokinin-8 from isolated nerve terminals and comparison with exocytosis of classical transmitters. Journal of Neurochemistry. 56: 1394-400. PMID 1672149 DOI: 10.1111/J.1471-4159.1991.Tb11437.X  0.387
1991 McMahon HT, Nicholls DG. Transmitter glutamate release from isolated nerve terminals: evidence for biphasic release and triggering by localized Ca2+. Journal of Neurochemistry. 56: 86-94. PMID 1670958 DOI: 10.1111/j.1471-4159.1991.tb02566.x  0.401
1990 Muniz ZM, Tibbs GR, Maschot P, Bougis P, Nicholls DG, Dolly JO. Homologues of a K(+) channel blocker ?-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration. Neurochemistry International. 16: 105-12. PMID 20504547  0.325
1990 McMahon HT, Nicholls DG. The relationship between cytoplasmic free Ca2+ and the release of glutamate from synaptosomes. Biochemical Society Transactions. 18: 375-7. PMID 2197130 DOI: 10.1042/bst0180375  0.353
1990 Courtney MJ, Lambert JJ, Nicholls DG. Glutamate-receptor-mediated regulation of the cytoplasmic free calcium level in cultured cerebellar granule cells. Biochemical Society Transactions. 18: 420-1. PMID 2164986 DOI: 10.1042/Bst0180420  0.329
1990 Courtney MJ, Lambert JJ, Nicholls DG. The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3873-9. PMID 1980131 DOI: 10.1523/Jneurosci.10-12-03873.1990  0.387
1990 McMahon HT, Nicholls DG. Glutamine and aspartate loading of synaptosomes: a reevaluation of effects on calcium-dependent excitatory amino acid release. Journal of Neurochemistry. 54: 373-80. PMID 1967628 DOI: 10.1111/j.1471-4159.1990.tb01883.x  0.333
1989 Wilkinson RJ, Nicholls DG. Compartmentation of glutamate and aspartate within cerebral cortical synaptosomes: evidence for a non-cytoplasmic origin for the calcium-releasable pool of glutamate. Neurochemistry International. 15: 191-7. PMID 20504483 DOI: 10.1016/0197-0186(89)90100-9  0.311
1989 McMahon HT, Barrie AP, Lowe M, Nicholls DG. Glutamate release from guinea-pig synaptosomes: stimulation by reuptake-induced depolarization. Journal of Neurochemistry. 53: 71-9. PMID 2566656 DOI: 10.1111/j.1471-4159.1989.tb07296.x  0.332
1989 Tibbs GR, Dolly JO, Nicholls DG. Dendrotoxin, 4-aminopyridine, and beta-bungarotoxin act at common loci but by two distinct mechanisms to induce Ca2+-dependent release of glutamate from guinea-pig cerebrocortical synaptosomes. Journal of Neurochemistry. 52: 201-6. PMID 2562805 DOI: 10.1111/j.1471-4159.1989.tb10917.x  0.311
1989 Tibbs GR, Barrie AP, Van Mieghem FJ, McMahon HT, Nicholls DG. Repetitive action potentials in isolated nerve terminals in the presence of 4-aminopyridine: effects on cytosolic free Ca2+ and glutamate release. Journal of Neurochemistry. 53: 1693-9. PMID 2553862 DOI: 10.1111/j.1471-4159.1989.tb09232.x  0.416
1989 Tibbs GR, Nicholls DG, Dolly JO. Dendrotoxin and charybdotoxin increase the cytosolic concentration of free Ca2+ in cerebrocortical synaptosomes: an effect not shared by apamin. Febs Letters. 255: 159-62. PMID 2477276 DOI: 10.1016/0014-5793(89)81081-6  0.355
1988 Kauppinen RA, McMahon HT, Nicholls DG. Ca2+-dependent and Ca2+-independent glutamate release, energy status and cytosolic free Ca2+ concentration in isolated nerve terminals following metabolic inhibition: possible relevance to hypoglycaemia and anoxia. Neuroscience. 27: 175-82. PMID 2904664 DOI: 10.1016/0306-4522(88)90228-X  0.405
1988 Pocock JM, Murphie HM, Nicholls DG. Kainic acid inhibits the synaptosomal plasma membrane glutamate carrier and allows glutamate leakage from the cytoplasm but does not affect glutamate exocytosis. Journal of Neurochemistry. 50: 745-51. PMID 2892890 DOI: 10.1111/j.1471-4159.1988.tb02977.x  0.329
1988 McMAHON HT, KAUPPINEN R, NICHOLLS DG. Energetics of Ca2+ -dependent glutamate release from synaptosomes and the effect of experimental anoxia, hypoglycaemia and ischaemia Biochemical Society Transactions. 16: 880-881. DOI: 10.1042/bst0160880  0.355
1988 McMahon HT, Kauppinen R, Nicholls DG. Energetics of Ca2+-dependent glutamate release from synaptosomes and the effect of experimental anoxia, hypoglycaemia and ischaemia Biochemical Society Transactions. 16: 880-881.  0.355
1987 Sihra TS, Nicholls DG. 4-Aminobutyrate can be released exocytotically from guinea-pig cerebral cortical synaptosomes. Journal of Neurochemistry. 49: 261-7. PMID 3585335 DOI: 10.1111/j.1471-4159.1987.tb03424.x  0.302
1987 Sanchez-Prieto J, Sihra TS, Nicholls DG. Characterization of the exocytotic release of glutamate from guinea-pig cerebral cortical synaptosomes. Journal of Neurochemistry. 49: 58-64. PMID 2884280 DOI: 10.1111/j.1471-4159.1987.tb03394.x  0.422
1987 Nicholls DG, Sihra TS, Sanchez-Prieto J. Calcium-dependent and -independent release of glutamate from synaptosomes monitored by continuous fluorometry. Journal of Neurochemistry. 49: 50-7. PMID 2884279 DOI: 10.1111/j.1471-4159.1987.tb03393.x  0.39
1987 Sanchez-Prieto J, Sihra TS, Evans D, Ashton A, Dolly JO, Nicholls DG. Botulinum toxin A blocks glutamate exocytosis from guinea-pig cerebral cortical synaptosomes. European Journal of Biochemistry / Febs. 165: 675-81. PMID 2439334 DOI: 10.1111/J.1432-1033.1987.Tb11494.X  0.413
1986 Kauppinen RA, Nicholls DG. Pyruvate utilization by synaptosomes is independent of calcium. Febs Letters. 199: 222-6. PMID 3084295 DOI: 10.1016/0014-5793(86)80484-7  0.375
1986 Kauppinen RA, Sihra TS, Nicholls DG. Divalent cation modulation of the ionic permeability of the synaptosomal plasma membrane. Biochimica Et Biophysica Acta. 860: 178-84. PMID 2427114 DOI: 10.1016/0005-2736(86)90513-4  0.307
1986 SIHRA TS, NICHOLLS DG. Ca2+-independent and Ca2+ -dependent γ-aminobutyrate release occur from distinct compartments within guinea-pig cerebral cortical synaptosomes Biochemical Society Transactions. 14: 909-910. DOI: 10.1042/bst0140909  0.351
1986 KAUPPINEN RA, SIHRA TS, NICHOLLS DG. The role of external Ca2++ in synaptosomal membrane bioenergetics Biochemical Society Transactions. 14: 889-890. DOI: 10.1042/bst0140889  0.303
1984 Sihra TS, Scott IG, Nicholls DG. Ionophore A23187, verapamil, protonophores, and veratridine influence the release of gamma-aminobutyric acid from synaptosomes by modulation of the plasma membrane potential rather than the cytosolic calcium. Journal of Neurochemistry. 43: 1624-30. PMID 6436439 DOI: 10.1111/j.1471-4159.1984.tb06087.x  0.379
1982 Nicholls DG, Rugolo M, Scott IG, Meldolesi J. alpha-latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes. Proceedings of the National Academy of Sciences of the United States of America. 79: 7924-8. PMID 6961460 DOI: 10.1073/Pnas.79.24.7924  0.377
1981 Akerman KE, Nicholls DG. ATP depletion increases Ca2+ uptake by synaptosomes. Febs Letters. 135: 212-4. PMID 7319036  0.357
1981 Akerman KE, Nicholls DG. Ca2+ transport by intact synaptosomes: the voltage-dependent Ca2+ channel and a re-evaluation of the role of sodium/calcium exchange. European Journal of Biochemistry / Febs. 117: 491-7. PMID 6269842  0.353
1981 Åkerman KEO, Nicholls DG. MECHANISM OF DEPOLARISATION-INDUCED Ca2+ UPTAKE BY SYNAPTOSOMES Biochemical Society Transactions. 9: 134P-134P. DOI: 10.1042/bst009134pc  0.318
1981 Nicholls D. Some recent advances in mitochondrial calcium transport Trends in Biochemical Sciences. 6: 36-38. DOI: 10.1016/0968-0004(81)90014-1  0.357
1980 Nicholls DG, Brand MD. The nature of the calcium ion efflux induced in rat liver mitochondria by the oxidation of endogenous nicotinamide nucleotides. The Biochemical Journal. 188: 113-8. PMID 7406874 DOI: 10.1042/bj1880113  0.38
1980 Nicholls DG, Scott ID. The regulation of brain mitochondrial calcium-ion transport. The role of ATP in the discrimination between kinetic and membrane-potential-dependent calcium-ion efflux mechanisms. The Biochemical Journal. 186: 833-9. PMID 7396840 DOI: 10.1042/bj1860833  0.373
1980 Scott ID, Akerman KE, Nicholls DG. Calcium-ion transport by intact synaptosomes. Intrasynaptosomal compartmentation and the role of the mitochondrial membrane potential. The Biochemical Journal. 192: 873-80. PMID 7236243  0.32
1978 Nicholls DG. Calcium transport and porton electrochemical potential gradient in mitochondria from guinea-pig cerebral cortex and rat heart. The Biochemical Journal. 170: 511-22. PMID 348200  0.342
1978 Nicholls DG. The regulation of extramitochondrial free calcium ion concentration by rat liver mitochondria. The Biochemical Journal. 176: 463-74. PMID 33670  0.35
1973 Nicholls DG, Lindberg O. Brown-adipose-tissue mitochondria. The influence of albumin and nucleotides on passive ion permeabilities. European Journal of Biochemistry / Febs. 37: 523-30. PMID 4777251 DOI: 10.1111/J.1432-1033.1973.Tb03014.X  0.526
1972 Nicholls DG, Lindberg O. Inhibited respiration and ATPase activity of rat liver mitochondria under conditions of matrix condensation. Febs Letters. 25: 61-64. PMID 11946721 DOI: 10.1016/0014-5793(72)80454-X  0.466
1972 Nicholls DG, Grav HJ, Lindberg O. Mitochondrial from hamster brown-adipose tissue. Regulation of respiration in vitro by variations in volume of the matrix compartment. European Journal of Biochemistry / Febs. 31: 526-33. PMID 4650156 DOI: 10.1111/J.1432-1033.1972.Tb02561.X  0.494
Low-probability matches (unlikely to be authored by this person)
2001 Rego AC, Lambert JJ, Nicholls DG. Developmental profile of excitatory GABA(A) responses in cultured rat cerebellar granule cells. Neuroreport. 12: 477-82. PMID 11234749 DOI: 10.1097/00001756-200103050-00011  0.296
1985 SIHRA TS, NICHOLLS DG. Ca2+-dependent release of endogenous γ-aminobutyric acid from isolated nerve endings Biochemical Society Transactions. 13: 919-920. DOI: 10.1042/bst0130919  0.291
1999 Nicholls DG, Budd SL, Castilho RF, Ward MW. Glutamate excitotoxicity and neuronal energy metabolism. Annals of the New York Academy of Sciences. 893: 1-12. PMID 10672225 DOI: 10.1111/J.1749-6632.1999.TB07813.X  0.288
1990 Nicholls D, Attwell D. The release and uptake of excitatory amino acids. Trends in Pharmacological Sciences. 11: 462-8. PMID 1980041 DOI: 10.1016/0165-6147(90)90129-V  0.285
1983 Åkerman KE, Nicholls DG. Ca2+ transport and the regulation of transmitter release in isolated nerve endings Trends in Biochemical Sciences. 8: 63-64. DOI: 10.1016/0968-0004(83)90392-4  0.279
2007 Yadava N, Nicholls DG. Spare respiratory capacity rather than oxidative stress regulates glutamate excitotoxicity after partial respiratory inhibition of mitochondrial complex I with rotenone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7310-7. PMID 17611283 DOI: 10.1523/JNEUROSCI.0212-07.2007  0.278
1996 del Río E, Nicholls DG, Downes CP. Characterization of the effects of lithium and inositol on phosphoinositide turnover in cerebellar granule cells in primary culture. Journal of Neurochemistry. 66: 517-24. PMID 8592121 DOI: 10.1046/J.1471-4159.1996.66020517.X  0.277
1999 Nicholls DG, Budd SL, Ward MW, Castilho RF. Excitotoxicity and mitochondria. Biochemical Society Symposium. 66: 55-67. PMID 10989657 DOI: 10.1042/BSS0660055  0.274
1988 WILKINSON R, NICHOLLS D. Compartmentation of Ca2+ -dependent pools of glutamate and aspartate in isolated cerebral cortical nerve terminals by isotopic exchange and fractionation Biochemical Society Transactions. 16: 879-880. DOI: 10.1042/bst0160879  0.269
2005 Polster BM, Basañez G, Etxebarria A, Hardwick JM, Nicholls DG. Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. The Journal of Biological Chemistry. 280: 6447-54. PMID 15590628 DOI: 10.1074/Jbc.M413269200  0.268
1998 del Río E, Shinomura T, van der Kaay J, Nicholls DG, Downes CP. Disruption by lithium of phosphoinositide signalling in cerebellar granule cells in primary culture. Journal of Neurochemistry. 70: 1662-9. PMID 9523584 DOI: 10.1046/J.1471-4159.1998.70041662.X  0.267
1986 Nicholls DG, Sihra TS. Synaptosomes possess an exocytotic pool of glutamate. Nature. 321: 772-3. PMID 3713864 DOI: 10.1038/321772a0  0.265
2004 Jekabsons MB, Nicholls DG. In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamate. The Journal of Biological Chemistry. 279: 32989-3000. PMID 15166243 DOI: 10.1074/jbc.M401540200  0.259
1995 Budd DC, Nicholls DG. Protein kinase C-mediated suppression of the presynaptic adenosine A1 receptor by a facilitatory metabotropic glutamate receptor. Journal of Neurochemistry. 65: 615-21. PMID 7616216 DOI: 10.1046/J.1471-4159.1995.65020615.X  0.254
1998 Nicholls DG, Budd SL. Mitochondria and neuronal glutamate excitotoxicity. Biochimica Et Biophysica Acta. 1366: 97-112. PMID 9714760 DOI: 10.1016/S0005-2728(98)00123-6  0.25
1990 McMahon HT, Rosenthal L, Meldolesi J, Nicholls DG. Alpha-latrotoxin releases both vesicular and cytoplasmic glutamate from isolated nerve terminals. Journal of Neurochemistry. 55: 2039-47. PMID 1977887 DOI: 10.1111/J.1471-4159.1990.Tb05793.X  0.25
1985 SNELLING R, NICHOLLS DG. Ca2+ efflux and cycling across the synaptosomal plasma membrane Biochemical Society Transactions. 13: 918-919. DOI: 10.1042/bst0130918  0.248
1998 Budd DC, Nicholls DG. Arachidonic acid potentiates the duration of the metabotropic, protein kinase C-mediated, suppression of the inhibitory adenosine A1 receptor pathway in glutamatergic nerve terminals from rat cerebral cortex. Neuroscience Letters. 244: 133-6. PMID 9593507 DOI: 10.1016/S0304-3940(98)00157-8  0.242
2009 Gerencser AA, Mark KA, Hubbard AE, Divakaruni AS, Mehrabian Z, Nicholls DG, Polster BM. Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. Journal of Neurochemistry. 110: 990-1004. PMID 19493161 DOI: 10.1111/J.1471-4159.2009.06194.X  0.24
1986 Kauppinen RA, Nicholls DG. Failure to maintain glycolysis in anoxic nerve terminals. Journal of Neurochemistry. 47: 1864-9. PMID 3095495 DOI: 10.1111/j.1471-4159.1986.tb13100.x  0.239
2002 Anderson CM, Norquist BA, Vesce S, Nicholls DG, Soine WH, Duan S, Swanson RA. Barbiturates induce mitochondrial depolarization and potentiate excitotoxic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 9203-9. PMID 12417645 DOI: 10.1523/Jneurosci.22-21-09203.2002  0.238
2008 Nicholls DG. Oxidative stress and energy crises in neuronal dysfunction. Annals of the New York Academy of Sciences. 1147: 53-60. PMID 19076430 DOI: 10.1196/annals.1427.002  0.237
2001 Rego AC, Vesce S, Nicholls DG. The mechanism of mitochondrial membrane potential retention following release of cytochrome c in apoptotic GT1-7 neural cells. Cell Death and Differentiation. 8: 995-1003. PMID 11598797 DOI: 10.1038/sj.cdd.4400916  0.232
1992 McMahon H, Sihra T, Foran P, Dolly J, Weller U, Nicholls D. Barium-evoked glutamate and met-enkephalin release from synaptosomes: Insights into the locus of action of tetanus toxin Neurochemistry International. 21: L1. DOI: 10.1016/0197-0186(92)91893-2  0.231
2007 Oliveira JM, Jekabsons MB, Chen S, Lin A, Rego AC, Gonçalves J, Ellerby LM, Nicholls DG. Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic mice. Journal of Neurochemistry. 101: 241-9. PMID 17394466 DOI: 10.1111/J.1471-4159.2006.04361.X  0.231
1987 Kauppinen RA, Sihra TS, Nicholls DG. Aminooxyacetic acid inhibits the malate-aspartate shuttle in isolated nerve terminals and prevents the mitochondria from utilizing glycolytic substrates. Biochimica Et Biophysica Acta. 930: 173-8. PMID 3620514 DOI: 10.1016/0167-4889(87)90029-2  0.227
2000 Ward MW, Rego AC, Frenguelli BG, Nicholls DG. Mitochondrial Membrane Potential and Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells The Journal of Neuroscience. 20: 7208-7219. DOI: 10.1523/JNEUROSCI.20-19-07208.2000  0.224
1990 Courtney M, Lambert J, Nicholls D. The interactions between plasma membrane depolarization and glutamate receptor activation in the regulation of cytoplasmic free calcium in cultured cerebellar granule cells The Journal of Neuroscience. 10: 3873-3879. DOI: 10.1523/JNEUROSCI.10-12-03873.1990  0.221
2005 Vesce S, Jekabsons MB, Johnson-Cadwell LI, Nicholls DG. Acute glutathione depletion restricts mitochondrial ATP export in cerebellar granule neurons. The Journal of Biological Chemistry. 280: 38720-8. PMID 16172117 DOI: 10.1074/jbc.M506575200  0.219
1993 Nicholls DG. Ion channels and the regulation of neurotransmitter glutamate release. Biochemical Society Transactions. 21: 53-8. PMID 7680622 DOI: 10.1042/bst0210053  0.219
1997 Budd SL, Castilho RF, Nicholls DG. Mitochondrial membrane potential and hydroethidine-monitored superoxide generation in cultured cerebellar granule cells. Febs Letters. 415: 21-4. PMID 9326361 DOI: 10.1016/S0014-5793(97)01088-0  0.216
2006 Nicholls DG. Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons. The Journal of Biological Chemistry. 281: 14864-74. PMID 16551630 DOI: 10.1074/jbc.M510916200  0.215
2000 Nicholls DG, Budd SL. Mitochondria and neuronal survival. Physiological Reviews. 80: 315-60. PMID 10617771 DOI: 10.1152/PHYSREV.2000.80.1.315  0.214
1986 Rugolo M, Dolly JO, Nicholls DG. The mechanism of action of beta-bungarotoxin at the presynaptic plasma membrane. The Biochemical Journal. 233: 519-23. PMID 3954750 DOI: 10.1042/bj2330519  0.213
1988 BARRIE A, NICHOLLS DG. Presynaptic regulation of glutamate release from guinea-pig cortical synaptosomes Biochemical Society Transactions. 16: 881-882. DOI: 10.1042/bst0160881  0.207
1988 Barrie A, Nicholls DG. Presynaptic regulation of glutamate release from guinea-pig cortical synaptosomes Biochemical Society Transactions. 16: 881-882.  0.207
2010 Nicholls DG. Stochastic aspects of transmitter release and bioenergetic dysfunction in isolated nerve terminals. Biochemical Society Transactions. 38: 457-9. PMID 20298202 DOI: 10.1042/BST0380457  0.207
1986 Cunningham SA, Wiesinger H, Nicholls DG. Quantification of fatty acid activation of the uncoupling protein in brown adipocytes and mitochondria from the guinea-pig. European Journal of Biochemistry / Febs. 157: 415-20. PMID 3709541  0.206
2010 Alakhova DY, Rapoport NY, Batrakova EV, Timoshin AA, Li S, Nicholls D, Alakhov VY, Kabanov AV. Differential metabolic responses to pluronic in MDR and non-MDR cells: a novel pathway for chemosensitization of drug resistant cancers. Journal of Controlled Release : Official Journal of the Controlled Release Society. 142: 89-100. PMID 19815037 DOI: 10.1016/J.Jconrel.2009.09.026  0.204
1998 Nicholls DG. Presynaptic modulation of glutamate release. Progress in Brain Research. 116: 15-22. PMID 9932367 DOI: 10.1016/S0079-6123(08)60427-6  0.203
2010 Nicholls DG, Darley-Usmar VM, Wu M, Jensen PB, Rogers GW, Ferrick DA. Bioenergetic profile experiment using C2C12 myoblast cells. Journal of Visualized Experiments : Jove. PMID 21189469 DOI: 10.3791/2511  0.201
2012 Gerencser AA, Chinopoulos C, Birket MJ, Jastroch M, Vitelli C, Nicholls DG, Brand MD. Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria. The Journal of Physiology. 590: 2845-71. PMID 22495585 DOI: 10.1113/Jphysiol.2012.228387  0.2
2001 Rego AC, Ward MW, Nicholls DG. Mitochondria Control AMPA/Kainate Receptor-Induced Cytoplasmic Calcium Deregulation in Rat Cerebellar Granule Cells The Journal of Neuroscience. 21: 1893-1901. DOI: 10.1523/JNEUROSCI.21-06-01893.2001  0.2
2007 Nicholls DG, Johnson-Cadwell L, Vesce S, Jekabsons M, Yadava N. Bioenergetics of mitochondria in cultured neurons and their role in glutamate excitotoxicity. Journal of Neuroscience Research. 85: 3206-12. PMID 17455297 DOI: 10.1002/jnr.21290  0.199
1996 Sánchez-Prieto J, Budd DC, Herrero I, Vázquez E, Nicholls DG. Presynaptic receptors and the control of glutamate exocytosis. Trends in Neurosciences. 19: 235-9. PMID 8761959 DOI: 10.1016/0166-2236(96)10031-X  0.195
1992 Nicholls DG, Pocock J, Sihra T, McMahon H, Barrie A, Coffey E. The mechanism of transmitter glutamate release Neurochemistry International. 21: S19. DOI: 10.1016/0197-0186(92)91784-T  0.195
2007 Johnson-Cadwell LI, Jekabsons MB, Wang A, Polster BM, Nicholls DG. 'Mild Uncoupling' does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress. Journal of Neurochemistry. 101: 1619-31. PMID 17437552 DOI: 10.1111/j.1471-4159.2007.04516.x  0.195
1991 McMahon HT, Nicholls DG. The bioenergetics of neurotransmitter release. Biochimica Et Biophysica Acta. 1059: 243-64. PMID 1680396 DOI: 10.1016/S0005-2728(05)80210-5  0.195
1986 Kauppinen RA, Nicholls DG. Synaptosomal bioenergetics. The role of glycolysis, pyruvate oxidation and responses to hypoglycaemia. European Journal of Biochemistry / Febs. 158: 159-65. PMID 2874024 DOI: 10.1111/j.1432-1033.1986.tb09733.x  0.193
2009 Choi SW, Gerencser AA, Nicholls DG. Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: spare respiratory capacity and stochastic mitochondrial failure. Journal of Neurochemistry. 109: 1179-91. PMID 19519782 DOI: 10.1111/J.1471-4159.2009.06055.X  0.192
1991 Courtney MJ, Nicholls DG. Metabotropic receptor-mediated regulation of cytoplasmic free calcium in cultured cerebellar granule cells. Biochemical Society Transactions. 19: 154S. PMID 1653722 DOI: 10.1042/bst019154s  0.192
1981 Akerman KE, Nicholls DG. Calcium transport by intact synaptosomes. Influence of ionophore A23187 on plasma-membrane potential, plasma-membrane calcium transport, mitochondrial membrane potential, respiration, cytosolic free-calcium concentration and noradrenaline release. European Journal of Biochemistry / Febs. 115: 67-73. PMID 6785087  0.191
1998 Castilho RF, Hansson O, Ward MW, Budd SL, Nicholls DG. Mitochondrial Control of Acute Glutamate Excitotoxicity in Cultured Cerebellar Granule Cells The Journal of Neuroscience. 18: 10277-10286. DOI: 10.1523/JNEUROSCI.18-24-10277.1998  0.19
1977 Nicholls DG. The effective proton conductance of the inner membrane of mitochondria from brown adipose tissue. Dependency on proton electrochemical potential gradient. European Journal of Biochemistry / Febs. 77: 349-56. PMID 19250  0.19
1980 Scott ID, Nicholls DG. Energy transduction in intact synaptosomes. Influence of plasma-membrane depolarization on the respiration and membrane potential of internal mitochondria determined in situ. The Biochemical Journal. 186: 21-33. PMID 7370008 DOI: 10.1042/bj1860021  0.188
1996 Budd DC, Nicholls DG, McLaughlin M. The target of PKC induced suppression of adenosine inhibition of glutamate release from synaptosomes is downstream of the A1 receptor and G-protein coupling. Biochemical Society Transactions. 24: 429S. PMID 8878973 DOI: 10.1042/bst024429s  0.187
2006 Jekabsons MB, Nicholls DG. Bioenergetic analysis of cerebellar granule neurons undergoing apoptosis by potassium/serum deprivation. Cell Death and Differentiation. 13: 1595-610. PMID 16410795 DOI: 10.1038/sj.cdd.4401851  0.183
2015 Nicholls DG, Brand MD, Gerencser AA. Mitochondrial bioenergetics and neuronal survival modelled in primary neuronal culture and isolated nerve terminals. Journal of Bioenergetics and Biomembranes. 47: 63-74. PMID 25172197 DOI: 10.1007/S10863-014-9573-9  0.182
2003 Chalmers S, Nicholls DG. The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria. The Journal of Biological Chemistry. 278: 19062-70. PMID 12660243 DOI: 10.1074/Jbc.M212661200  0.18
2010 Gerencser AA, Chinopoulos C, Birket MJ, Jastroch M, Nicholls DG, Brand MD. Fluorescence measurement of absolute mitochondrial membrane potential in adherent cultured cells Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1797: 125. DOI: 10.1016/J.Bbabio.2010.04.372  0.179
2017 Nicholls DG. Brain mitochondrial calcium transport: Origins of the set-point concept and its application to physiology and pathology. Neurochemistry International. PMID 28057556 DOI: 10.1016/j.neuint.2016.12.018  0.177
1989 Nicholls DG. Regulation of calcium in isolated nerve terminals (synaptosomes): relationship to neurotransmitter release. Annals of the New York Academy of Sciences. 568: 81-8. PMID 2576509 DOI: 10.1111/j.1749-6632.1989.tb12493.x  0.176
1990 Muniz ZM, Tibbs GR, Maschot P, Bougis P, Nicholls DG, Dolly JO. Homologues of a K+ channel blocker α-dendrotoxin: characterization of synaptosomal binding sites and their coupling to elevation of cytosolic free calcium concentration Neurochemistry International. 16: 105-112. DOI: 10.1016/0197-0186(90)90130-L  0.175
1981 Nicholls DG, Åkerman KEO. TRANSMITTER RELEASE AND MITOCHONDRIAL DEPOLARISATION INDUCED BY A23l87 Biochemical Society Transactions. 9: 134P-134P. DOI: 10.1042/bst009134pb  0.172
1989 Nicholls DG. Release of glutamate, aspartate, and gamma-aminobutyric acid from isolated nerve terminals. Journal of Neurochemistry. 52: 331-41. PMID 2562986 DOI: 10.1111/j.1471-4159.1989.tb09126.x  0.169
2018 Nicholls DG. Fluorescence Measurement of Mitochondrial Membrane Potential Changes in Cultured Cells. Methods in Molecular Biology (Clifton, N.J.). 1782: 121-135. PMID 29850997 DOI: 10.1007/978-1-4939-7831-1_7  0.169
2012 Nicholls DG. Fluorescence measurement of mitochondrial membrane potential changes in cultured cells. Methods in Molecular Biology (Clifton, N.J.). 810: 119-33. PMID 22057564 DOI: 10.1007/978-1-61779-382-0_8  0.169
2014 Göhring I, Sharoyko VV, Malmgren S, Andersson LE, Spégel P, Nicholls DG, Mulder H. Chronic high glucose and pyruvate levels differentially affect mitochondrial bioenergetics and fuel-stimulated insulin secretion from clonal INS-1 832/13 cells. The Journal of Biological Chemistry. 289: 3786-98. PMID 24356960 DOI: 10.1074/jbc.M113.507335  0.169
1989 Rial E, Aréchaga I, Sainz-de-la-Maza E, Nicholls DG. Effect of hydrophobic sulphydryl reagents on the uncoupling protein and inner-membrane anion channel of brown-adipose-tissue mitochondria. European Journal of Biochemistry / Febs. 182: 187-93. PMID 2471645  0.167
1987 Cunningham SA, Nicholls DG. Induction of functional uncoupling protein in guinea pigs infused with noradrenaline. Studies with isolated brown adipocytes. The Biochemical Journal. 245: 485-91. PMID 3663174  0.167
2016 Nicholls DG. The Pancreatic β-Cell: A Bioenergetic Perspective. Physiological Reviews. 96: 1385-447. PMID 27582250 DOI: 10.1152/physrev.00009.2016  0.165
1982 Locke RM, Rial E, Scott ID, Nicholls DG. Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria. European Journal of Biochemistry / Febs. 129: 373-80. PMID 6295765  0.163
1976 Heaton GM, Nicholls DG. The calcium conductance of the inner membrane of rat liver mitochondria and the determination of the calcium electrochemical gradient. The Biochemical Journal. 156: 635-46. PMID 949345  0.162
1981 Akerman KE, Nicholls DG. Intrasynaptosomal compartmentation of calcium during depolarization-induced calcium uptake across the plasma membrane. Biochimica Et Biophysica Acta. 645: 41-8. PMID 7260086  0.162
2017 Mookerjee SA, Gerencser AA, Nicholls DG, Brand MD. Quantifying Intracellular Rates of Glycolytic and Oxidative ATP Production and Consumption Using Extracellular Flux Measurements. The Journal of Biological Chemistry. PMID 28270511 DOI: 10.1074/Jbc.M116.774471  0.161
2011 Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells. The Biochemical Journal. 435: 297-312. PMID 21726199 DOI: 10.1042/Bj20110162  0.159
2021 Nicholls DG. Mitochondrial proton leaks and uncoupling proteins. Biochimica Et Biophysica Acta. Bioenergetics. 1862: 148428. PMID 33798544 DOI: 10.1016/j.bbabio.2021.148428  0.158
2007 Ward MW, Huber HJ, Weisová P, Düssmann H, Nicholls DG, Prehn JH. Mitochondrial and plasma membrane potential of cultured cerebellar neurons during glutamate-induced necrosis, apoptosis, and tolerance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8238-49. PMID 17670970 DOI: 10.1523/JNEUROSCI.1984-07.2007  0.157
1979 NICHOLLS DG, SCOTT ID. The Role of Adenosine Triphosphate in the Regulation of Free Calcium Ion Concentrations by Mitochondria from Guinea-Pig Cerebral Cortex Biochemical Society Transactions. 7: 1126-1126. DOI: 10.1042/bst0071126  0.156
2011 Choi SW, Gerencser AA, Lee DW, Rajagopalan S, Nicholls DG, Andersen JK, Brand MD. Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4524-34. PMID 21430153 DOI: 10.1523/Jneurosci.5817-10.2011  0.156
2014 Polster BM, Nicholls DG, Ge SX, Roelofs BA. Use of potentiometric fluorophores in the measurement of mitochondrial reactive oxygen species. Methods in Enzymology. 547: 225-50. PMID 25416361 DOI: 10.1016/B978-0-12-801415-8.00013-8  0.156
1981 Nicholls DG. THE TRANSPORT OP CALCIUM ACROSS THE MITOCHONDRIAL INNER MEMBRANE Biochemical Society Transactions. 9: 7P-7P. DOI: 10.1042/bst009007p  0.156
1985 Nicholls DG. A role for the mitochondrion in the protection of cells against calcium overload? Progress in Brain Research. 63: 97-106. PMID 3835584 DOI: 10.1016/S0079-6123(08)61978-0  0.154
2008 Gerencser AA, Doczi J, Sorci L, Osterman A, Nicholls DG, Adam-Vizi V. S7.6 Glutamate exposure of cortical neurons evokes initial oxidation of NADPH in mitochondria followed by a delayed oxidation of NADH: Delayed redox and calcium deregulation Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1777: S46. DOI: 10.1016/J.Bbabio.2008.05.183  0.153
1976 Nicholls DG. Hamster brown-adipose-tissue mitochondria. Purine nucleotide control of the ion conductance of the inner membrane, the nature of the nucleotide binding site. European Journal of Biochemistry / Febs. 62: 223-8. PMID 1253787  0.153
1987 Nicholls DG, Sihra TS, Sanchez-Prieto J. The role of the plasma membrane and intracellular organelles in synaptosomal calcium regulation. Society of General Physiologists Series. 42: 31-43. PMID 3333194  0.153
1986 Nicholls DG. Intracellular calcium homeostasis. British Medical Bulletin. 42: 353-8. PMID 3307995  0.153
2002 Nicholls DG. Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease. The International Journal of Biochemistry & Cell Biology. 34: 1372-81. PMID 12200032 DOI: 10.1016/S1357-2725(02)00077-8  0.153
1987 Fernández M, Nicholls DG, Rial E. The uncoupling protein from brown-adipose-tissue mitochondria. Chymotrypsin-induced structural and functional modifications. European Journal of Biochemistry / Febs. 164: 675-80. PMID 3569282  0.151
2000 Nicholls DG, Ward MW. Mitochondrial membrane potential and neuronal glutamate excitotoxicity: mortality and millivolts. Trends in Neurosciences. 23: 166-74. PMID 10717676 DOI: 10.1016/S0166-2236(99)01534-9  0.15
2003 Nicholls DG. Bioenergetics and transmitter release in the isolated nerve terminal. Neurochemical Research. 28: 1433-41. PMID 14570388 DOI: 10.1023/A:1025653805029  0.149
1974 Nicholls DG. The influence of respiration and ATP hydrolysis on the proton-electrochemical gradient across the inner membrane of rat-liver mitochondria as determined by ion distribution. European Journal of Biochemistry / Febs. 50: 305-15. PMID 4452361 DOI: 10.1111/j.1432-1033.1974.tb03899.x  0.149
2009 Chinta SJ, Rane A, Yadava N, Andersen JK, Nicholls DG, Polster BM. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Free Radical Biology & Medicine. 46: 939-47. PMID 19280713 DOI: 10.1016/J.Freeradbiomed.2009.01.010  0.149
2004 Nicholls DG. Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures. Current Molecular Medicine. 4: 149-77. PMID 15032711 DOI: 10.2174/1566524043479239  0.147
1979 Scott ID, Nicholls DG. The estimation of the electrical potential across the inner membrane of mitochondria within intact synaptosomes [proceedings]. Biochemical Society Transactions. 7: 969-70. PMID 510760 DOI: 10.1042/bst0070969  0.145
1984 Rafael J, Nicholls DG. Mitochondrial membrane potential monitored in situ within isolated guinea pig brown adipocytes by a styryl pyridinium fluorescent indicator. Febs Letters. 170: 181-5. PMID 6723960  0.145
1986 Rial E, Nicholls DG. Chemical modification of the brown fat mitochondrial uncoupling protein with tetranitromethane. Febs Letters. 198: 29-32. PMID 3956727 DOI: 10.1016/0014-5793(86)81178-4  0.143
1984 Nicholls DG, Snelling R, Rial E. Proton and calcium circuits across the mitochondrial inner membrane. Biochemical Society Transactions. 12: 388-90. PMID 6329839  0.143
1978 Brand MD, Harper WG, Nicholls DG, Ingledew WJ. Unequal charge separation by different coupling spans of the mitochondrial electron transport chain. Febs Letters. 95: 125-9. PMID 720593 DOI: 10.1016/0014-5793(78)80066-0  0.142
2008 Gerencser AA, Nicholls DG. Measurement of instantaneous velocity vectors of organelle transport: mitochondrial transport and bioenergetics in hippocampal neurons. Biophysical Journal. 95: 3079-99. PMID 18757564 DOI: 10.1529/Biophysj.108.135657  0.14
2018 Mookerjee SA, Gerencser AA, Nicholls DG, Brand MD. Quantifying intracellular rates of glycolytic and oxidative ATP production and consumption using extracellular flux measurements. The Journal of Biological Chemistry. 293: 12649-12652. PMID 30097494 DOI: 10.1074/jbc.AAC118.004855  0.14
2016 Mookerjee SA, Nicholls DG, Brand MD. Determining Maximum Glycolytic Capacity Using Extracellular Flux Measurements. Plos One. 11: e0152016. PMID 27031845 DOI: 10.1371/Journal.Pone.0152016  0.139
2009 Nicholls DG. Spare respiratory capacity, oxidative stress and excitotoxicity. Biochemical Society Transactions. 37: 1385-8. PMID 19909281 DOI: 10.1042/BST0371385  0.138
1998 González-Barroso MM, Fleury C, Bouillaud F, Nicholls DG, Rial E. The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. The Journal of Biological Chemistry. 273: 15528-32. PMID 9624141 DOI: 10.1074/jbc.273.25.15528  0.138
2009 Mallajosyula JK, Chinta SJ, Rajagopalan S, Nicholls DG, Andersen JK. Metabolic control analysis in a cellular model of elevated MAO-B: relevance to Parkinson's disease. Neurotoxicity Research. 16: 186-93. PMID 19526285 DOI: 10.1007/S12640-009-9032-2  0.138
1981 Zoccarato F, Nicholls DG. Phosphate-independent calcium efflux from liver mitochondria. Febs Letters. 128: 275-7. PMID 6167468  0.138
1980 Nicholls DG, Crompton M. Mitochondrial calcium transport. Febs Letters. 111: 261-8. PMID 6987089  0.137
1980 Nicholls DG, Scott ID. The role of mitochondria in the regulation of calcium ion transport in synaptosomes. Biochemical Society Transactions. 8: 264-6. PMID 7399048 DOI: 10.1042/bst0080264  0.136
2007 Chinta SJ, Kumar MJ, Hsu M, Rajagopalan S, Kaur D, Rane A, Nicholls DG, Choi J, Andersen JK. Inducible alterations of glutathione levels in adult dopaminergic midbrain neurons result in nigrostriatal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13997-4006. PMID 18094238 DOI: 10.1523/Jneurosci.3885-07.2007  0.136
1998 Nicholls DG. Strategies for receptor control of neurotransmitter release. Advances in Pharmacology (San Diego, Calif.). 42: 110-3. PMID 9327859 DOI: 10.1016/S1054-3589(08)60708-5  0.135
2008 Amo T, Yadava N, Oh R, Nicholls DG, Brand MD. Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene. 411: 69-76. PMID 18280061 DOI: 10.1016/J.Gene.2008.01.007  0.135
1974 Nicholls DG. Hamster brown-adipose-tissue mitochondria. The chloride permeability of the inner membrane under respiring conditions, the influence of purine nucleotides. European Journal of Biochemistry / Febs. 49: 585-93. PMID 4442426 DOI: 10.1111/j.1432-1033.1974.tb03862.x  0.134
1967 Nicholls DG, Shepherd D, Garland PB. A continuous recording technique for the measurement of carbon dioxide, and its application to mitochondrial oxidation and decarboxylation reactions. The Biochemical Journal. 103: 677-91. PMID 4292835  0.132
2001 Nicholls DG. A history of UCP1. Biochemical Society Transactions. 29: 751-5. PMID 11709069 DOI: 10.1042/BST0290751  0.132
1982 Locke RM, Rial E, Nicholls DG. The acute regulation of mitochondrial proton conductance in cells and mitochondria from the brown fat of cold-adapted and warm-adapted guinea pigs. European Journal of Biochemistry / Febs. 129: 381-7. PMID 6295766  0.131
2005 ÅKERMAN KEO, NICHOLLS DG. Calcium Transport by Intact Synaptosomes European Journal of Biochemistry. 115: 67-73. DOI: 10.1111/J.1432-1033.1981.TB06198.X  0.13
2009 Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. Journal of Neuroscience Research. 87: 164-70. PMID 18711728 DOI: 10.1002/jnr.21826  0.13
2012 Nicholls DG. Mitochondria, sodium, and calcium in neuronal dysfunction Mitochondrial Dysfunction in Neurodegenerative Disorders. 113-125. DOI: 10.1007/978-0-85729-701-3_7  0.13
2010 Nicholls DG. Mitochondrial ion circuits. Essays in Biochemistry. 47: 25-35. PMID 20533898 DOI: 10.1042/bse0470025  0.13
2003 Kumar MJ, Nicholls DG, Andersen JK. Oxidative alpha-ketoglutarate dehydrogenase inhibition via subtle elevations in monoamine oxidase B levels results in loss of spare respiratory capacity: implications for Parkinson's disease. The Journal of Biological Chemistry. 278: 46432-9. PMID 12963742 DOI: 10.1074/Jbc.M306378200  0.129
1978 Heaton GM, Wagenvoord RJ, Kemp A, Nicholls DG. Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. European Journal of Biochemistry / Febs. 82: 515-21. PMID 624284 DOI: 10.1111/J.1432-1033.1978.Tb12045.X  0.129
1997 Nicholls DG. The non-Ohmic proton leak--25 years on. Bioscience Reports. 17: 251-7. PMID 9337480 DOI: 10.1023/A:1027376426860  0.128
2012 Choi SW, Gerencser AA, Ng R, Flynn JM, Melov S, Danielson SR, Gibson BW, Nicholls DG, Bredesen DE, Brand MD. No consistent bioenergetic defects in presynaptic nerve terminals isolated from mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16775-84. PMID 23175831 DOI: 10.1523/Jneurosci.2414-12.2012  0.128
1974 Nicholls DG. Hamster brown-adipose-tissue mitochondria. The control of respiration and the proton electrochemical potential gradient by possible physiological effectors of the proton conductance of the inner membrane. European Journal of Biochemistry / Febs. 49: 573-83. PMID 4442425 DOI: 10.1111/j.1432-1033.1974.tb03861.x  0.127
1969 König T, Nicholls DG, Garland PB. The inhibition of pyruvate and Ls(+)-isocitrate oxidation by succinate oxidation in rat liver mitochondria. The Biochemical Journal. 114: 589-96. PMID 4309530  0.124
1986 Rial E, Nicholls DG. Chemical modification of the brown-fat-mitochondrial uncoupling protein with tetranitromethane and N-ethylmaleimide. A cysteine residue is implicated in the nucleotide regulation of anion permeability. European Journal of Biochemistry / Febs. 161: 689-94. PMID 3024980  0.124
1994 Nicholls DG, Coffey ET. Glutamate exocytosis from isolated nerve terminals. Advances in Second Messenger and Phosphoprotein Research. 29: 189-203. PMID 7848711  0.123
2009 Malmgren S, Nicholls DG, Taneera J, Bacos K, Koeck T, Tamaddon A, Wibom R, Groop L, Ling C, Mulder H, Sharoyko VV. Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion. The Journal of Biological Chemistry. 284: 32395-404. PMID 19797055 DOI: 10.1074/jbc.M109.026708  0.122
1977 Heaton GM, Nicholls DG. The structural specificity of the nucleotide-binding site and the reversible nature of the inhibition of proton conductance induced by bound nucleotides in brown-adipose-tissue mitochondria. Biochemical Society Transactions. 5: 210-2. PMID 19317  0.122
2023 Nicholls DG. Fifty years on: How we uncovered the unique bioenergetics of brown adipose tissue. Acta Physiologica (Oxford, England). e13938. PMID 36692160 DOI: 10.1111/apha.13938  0.122
1981 Locke R, Nicholls D. MITOCHONDRIAL MEMBRANE POTENTIALS IN BROWN AND WHITE ADIPOCYTES Biochemical Society Transactions. 9: 176P-176P. DOI: 10.1042/bst009176pb  0.121
2011 Brand MD, Nicholls DG. Assessing mitochondrial dysfunction in cells (Biochemical Journal (2011) 435, (297-312)) Biochemical Journal. 437: 575.  0.119
2004 Nicholls DG. Mitochondrial membrane potential and aging. Aging Cell. 3: 35-40. PMID 14965354 DOI: 10.1111/j.1474-9728.2003.00079.x  0.119
2012 Siddiqui A, Rivera-Sánchez S, Castro Mdel R, Acevedo-Torres K, Rane A, Torres-Ramos CA, Nicholls DG, Andersen JK, Ayala-Torres S. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington's disease. Free Radical Biology & Medicine. 53: 1478-88. PMID 22709585 DOI: 10.1016/J.Freeradbiomed.2012.06.008  0.117
1989 Nicholls DG. Measurement of transported calcium in synaptosomes. Methods in Enzymology. 174: 3-9. PMID 2633030  0.117
2015 Mookerjee SA, Goncalves RL, Gerencser AA, Nicholls DG, Brand MD. The contributions of respiration and glycolysis to extracellular acid production. Biochimica Et Biophysica Acta. 1847: 171-81. PMID 25449966 DOI: 10.1016/J.Bbabio.2014.10.005  0.117
1986 RAFAEL J, FESSER W, NICHOLLS DG. Increased response to noradrenaline of isolated brown adipocytes from guinea pigs during cold-adaptation Biochemical Society Transactions. 14: 282-283. DOI: 10.1042/bst0140282  0.115
2017 Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, ... ... Nicholls DG, et al. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death and Differentiation. PMID 29229998 DOI: 10.1038/S41418-017-0020-4  0.113
1999 Nicholls DG, Rial E. A history of the first uncoupling protein, UCP1. Journal of Bioenergetics and Biomembranes. 31: 399-406. PMID 10653469 DOI: 10.1023/A:1005436121005  0.112
1978 Nicholls DG, Bernson VS, Heaton GM. The identification of the component in the inner membrane of brown adipose tissue mitochondria responsible for regulating energy dissipation. Experientia. Supplementum. 32: 89-93. PMID 348493  0.111
2006 Nicholls DG. CELL BIOLOGY: Energizing Eukaryotes Science. 311: 1869-1869. DOI: 10.1126/SCIENCE.1126251  0.109
1985 CUNNINGHAM SA, NICHOLLS DG. Fatty acids as second messengers for noradrenaline-induced uncoupling of intact isolated brown adipocytes Biochemical Society Transactions. 13: 739-740. DOI: 10.1042/bst0130739  0.109
2018 Fex M, Nicholas LM, Vishnu N, Medina A, Sharoyko VV, Nicholls DG, Spégel P, Mulder H. The pathogenetic role of β-cell mitochondria in type 2 diabetes. The Journal of Endocrinology. 236: R145-R159. PMID 29431147 DOI: 10.1530/JOE-17-0367  0.107
2023 Nicholls DG, Brand MD. A critical assessment of the role of creatine in brown adipose tissue thermogenesis. Nature Metabolism. PMID 36624158 DOI: 10.1038/s42255-022-00718-2  0.106
2010 Ayala-Torres S, Andersen JK, Torres-Ramos CA, Nicholls DG, Acevedo-Torres K, Siddiqui A, Rivera S. 98 Mutant huntingtin leads to increased levels of mitochondrial DNA damage and mitochondrial dysfunction in mouse striatal cells Mitochondrion. 10: 227. DOI: 10.1016/j.mito.2009.12.090  0.106
1989 Nicholls DG, Rial E. Measurement of proton leakage across mitochondrial inner membranes and its relation to protonmotive force. Methods in Enzymology. 174: 85-94. PMID 2561174  0.105
1977 Nicholls DG. Stoicheiometries of proton translocation by mitochondria. Biochemical Society Transactions. 5: 200-3. PMID 19316  0.105
1973 Sánchez M, Nicholls DG, Brindley DN. [The relationship between palmitoyl-coenzyme A synthetase activity and esterification of sn-glycerol 3-phosphate in rat liver mitochondria]. The Biochemical Journal. 132: 697-706. PMID 4721605  0.105
2008 Nicholls DG. Forty years of Mitchell's proton circuit: From little grey books to little grey cells. Biochimica Et Biophysica Acta. 1777: 550-6. PMID 18423395 DOI: 10.1016/j.bbabio.2008.03.014  0.105
2008 Gerencser AA, Nicholls DG. S7.10 Bioenergetics and mitochondrial transport in hippocampal neurons Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1777: S47. DOI: 10.1016/J.Bbabio.2008.05.187  0.102
1984 Rial E, Nicholls DG. The mitochondrial uncoupling protein from guinea-pig brown adipose tissue. Synchronous increase in structural and functional parameters during cold-adaptation. The Biochemical Journal. 222: 685-93. PMID 6091621  0.102
1977 Nicholls DG, Bernson VS. Inter-relationships between proton electrochemical gradient, adenine-nucleotide phosphorylation potential and respiration, during substrate-level and oxidative phosphorylation by mitochondria from brown adipose tissue of cold-adapted guinea-pigs. European Journal of Biochemistry / Febs. 75: 601-12. PMID 18347  0.101
1981 Nicholls DG, Akerman KE. Biochemical approaches to the study of cytosolic calcium regulation in nerve endings. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 296: 115-22. PMID 6121337  0.1
1970 Kuylenstierna B, Nicholls DG, Hovmöller S, Ernster L. Effect of trypsin on mitochondrial and microsomal enzymes. European Journal of Biochemistry / Febs. 12: 419-26. PMID 4315397 DOI: 10.1111/J.1432-1033.1970.TB00868.X  0.098
2014 Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, ... ... Nicholls DG, et al. The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 514: E12-4. PMID 25341790 DOI: 10.1038/Nature13858  0.098
1998 Budd SL, Nicholls DG. Mitochondria in the life and death of neurons. Essays in Biochemistry. 33: 43-52. PMID 10488440 DOI: 10.1042/BSE0330043  0.097
2000 Nicholls DG. from the field Public Culture. 12: 575-576. DOI: 10.1215/08992363-12-2-575  0.097
2007 Nicholls DG. Bioenergetics Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. 3-16. DOI: 10.1007/978-0-387-30411-3_1  0.096
2008 Mallajosyula JK, Kaur D, Chinta SJ, Rajagopalan S, Rane A, Nicholls DG, Di Monte DA, Macarthur H, Andersen JK. MAO-B elevation in mouse brain astrocytes results in Parkinson's pathology. Plos One. 3: e1616. PMID 18286173 DOI: 10.1371/Journal.Pone.0001616  0.096
1985 Peterson C, Nicholls DG, Gibson GE. Subsynaptosomal calcium distribution during hypoxia and 3,4-diaminopyridine treatment. Journal of Neurochemistry. 45: 1779-90. PMID 4056792 DOI: 10.1111/j.1471-4159.1985.tb10534.x  0.096
1979 Cox JC, Nicholls DG, Ingledew WJ. Transmembrane electrical potential and transmembrane pH gradient in the acidophile Thiobacillus ferro-oxidans. The Biochemical Journal. 178: 195-200. PMID 35160  0.095
2007 Polster BM, Arze R, Lyttle MH, Nicholls DG, Hudson D. Solid Phase Synthesis of Dual Labeled Peptides: Development of Cell Permeable Calpain Specific Substrates. International Journal of Peptide Research and Therapeutics. 13: 83-91. PMID 32214925 DOI: 10.1007/s10989-006-9049-9  0.095
2006 Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/J.Jalz.2006.08.008  0.095
1977 Nicholls DG. Cellular mechanisms in brown fat thermogenesis mitochondria. Experientia. 33: 1130-1. PMID 891847 DOI: 10.1007/BF01922281  0.095
2018 Nicholls DG. Sirtuins, NAD+ and Mitochondrial Bioenergetics: A Critique Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e35-e36. DOI: 10.1016/j.bbabio.2018.09.354  0.094
1968 Garland PB, Shepherd D, Nicholls DG, Ontko J. Energy-dependent control of the tricarboxylic acid cycle by fatty acid oxidation in rat liver mitochondria. Advances in Enzyme Regulation. 6: 3-30. PMID 5720339  0.093
1981 Locke RM, Nicholls DG. A re-evaluation of the role of fatty acids in the physiological regulation of the proton conductance of brown adipose tissue mitochondria. Febs Letters. 135: 249-52. PMID 6274693  0.089
1980 Hoek JB, Nicholls DG, Williamson JR. Determination of the mitochondrial protonmotive force in isolated hepatocytes. The Journal of Biological Chemistry. 255: 1458-64. PMID 7354039  0.088
1984 Nicholls DG, Rial E. Brown fat mitochondria Trends in Biochemical Sciences. 9: 489-491. DOI: 10.1016/0968-0004(84)90319-0  0.086
2005 Nicholls DG. Commentary on: 'old and new data, new issues: the mitochondrial Deltapsi' by H. Tedeschi. Biochimica Et Biophysica Acta. 1710: 63-5; discussion 66. PMID 16242663 DOI: 10.1016/j.bbabio.2005.09.002  0.086
1989 Nicholls D. Membrane bioenergetics Febs Letters. 244: 494-494. DOI: 10.1016/0014-5793(89)80591-5  0.084
2002 Castro-Obregón S, Del Rio G, Chen SF, Swanson RA, Frankowski H, Rao RV, Stoka V, Vesce S, Nicholls DG, Bredesen DE. A ligand-receptor pair that triggers a non-apoptotic form of programmed cell death. Cell Death and Differentiation. 9: 807-17. PMID 12107824 DOI: 10.1038/Sj.Cdd.4401035  0.084
1974 Bernson SM, Nicholls DG. Acetate, a major end product of fatty-acid oxidation in hamster brown-adipose-tissue mitochondria. European Journal of Biochemistry / Febs. 47: 517-25. PMID 4434994  0.079
1985 Peterson C, Nicholls DG, Gibson GE. Subsynaptosomal distribution of calcium during aging and 3,4-diaminopyridine treatment. Neurobiology of Aging. 6: 297-304. PMID 4088426 DOI: 10.1016/0197-4580(85)90007-7  0.078
1986 Jackson JB, Nicholls DG. Methods for the determination of membrane potential in bioenergetic systems. Methods in Enzymology. 127: 557-77. PMID 3526088 DOI: 10.1016/0076-6879(86)27044-5  0.078
2009 Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, Brand MD. Quantitative microplate-based respirometry with correction for oxygen diffusion. Analytical Chemistry. 81: 6868-78. PMID 19555051 DOI: 10.1021/Ac900881Z  0.075
1976 Nicholls DG. The bioenergetics of brown adipose tissue mitochondria. Febs Letters. 61: 103-110. PMID 765149 DOI: 10.1016/0014-5793(76)81014-9  0.075
2015 Andersson LE, Valtat B, Bagge A, Sharoyko VV, Nicholls DG, Ravassard P, Scharfmann R, Spégel P, Mulder H. Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line. Plos One. 10: e0120879. PMID 25803449 DOI: 10.1371/journal.pone.0120879  0.075
2010 Nicholls DG. Proton circuits and mitochondrial dysfunction Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1797: 3. DOI: 10.1016/j.bbabio.2010.04.027  0.074
2007 Polster BM, Arze R, Lyttle MH, Nicholls DG, Hudson D. Solid phase synthesis of dual labeled peptides: Development of cell permeable calpain specific substrates International Journal of Peptide Research and Therapeutics. 13: 83-91. DOI: 10.1007/s10989-006-9049-9  0.074
2003 Samper E, Nicholls DG, Melov S. Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts. Aging Cell. 2: 277-85. PMID 14570235 DOI: 10.1046/j.1474-9728.2003.00062.x  0.073
1987 Rial E, Nicholls DG. The uncoupling protein from brown adipose tissue mitochondria. Revisiones Sobre Biologã­a Celular : Rbc. 11: 75-104. PMID 3324211  0.072
2000 Brown G, Nicholls D, Cooper C. Mitochondria and cell death31240 pp., 1999. Price: £65.0032Portland Press Ltd., London, ISBN 185578125533Reviewed by R. S. Sohal, Department of Biological Sciences, Southern Methodist University, Dallas, TX, USA Free Radical Biology and Medicine. 28: 1005. DOI: 10.1016/s0891-5849(00)00182-9  0.072
1979 Nicholls DG. Brown adipose tissue mitochondria. Biochimica Et Biophysica Acta. 549: 1-29. PMID 383147 DOI: 10.1016/0304-4173(79)90016-8  0.071
1986 Rafael J, Fesser W, Nicholls DG. Cold adaptation in guinea pig at level of isolated brown adipocyte. The American Journal of Physiology. 250: C228-35. PMID 3953778  0.071
2014 Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Dixon J, Connolly S, Cook A, Fisher A, Flaherty A, Humphries A, Ingall A, Jordan S, Lawson M, ... ... Nicholls D, et al. Discovery of AZD3199, An Inhaled Ultralong Acting β2 Receptor Agonist with Rapid Onset of Action. Acs Medicinal Chemistry Letters. 5: 416-21. PMID 24900851 DOI: 10.1021/ml4005232  0.07
2016 Nicholls DG. The Hunt for the Molecular Mechanism of Brown Fat Thermogenesis. Biochimie. PMID 27621145 DOI: 10.1016/j.biochi.2016.09.003  0.07
1963 LING JK, NICHOLLS DG. IMMOBILIZATION OF ELEPHANT SEALS USING SUCCINYLCHOLINE CHLORIDE. Nature. 200: 1021-2. PMID 14097732  0.07
1983 Rial E, Poustie A, Nicholls DG. Brown-adipose-tissue mitochondria: the regulation of the 32000-Mr uncoupling protein by fatty acids and purine nucleotides. European Journal of Biochemistry / Febs. 137: 197-203. PMID 6317384  0.069
1985 RIAL E, NICHOLLS DG. Chemical modification of the uncoupling protein from brown adipose tissue mitochondria Biochemical Society Transactions. 13: 738-739. DOI: 10.1042/bst0130738  0.068
1986 KAUPPINEN RA, NICHOLLS DG. Synaptosomal respiration and the ability to utilize non-glycolytic substrates Biochemical Society Transactions. 14: 361-361. DOI: 10.1042/bst0140361  0.064
1983 Rial E, Nicholls DG. The regulation of the proton conductance of brown fat mitochondria. Identification of functional and non-functional nucleotide-binding sites. Febs Letters. 161: 284-8. PMID 6311625 DOI: 10.1016/0014-5793(83)81026-6  0.064
2013 Sobayo T, Fine AS, Gunnar E, Kazlauskas C, Nicholls D, Mogul DJ. Synchrony dynamics across brain structures in limbic epilepsy vary between initiation and termination phases of seizures. Ieee Transactions On Bio-Medical Engineering. 60: 821-9. PMID 22389141 DOI: 10.1109/TBME.2012.2189113  0.063
1976 Nicholls DG. Brown fat mitochondria Trends in Biochemical Sciences. 1: 128-130. DOI: 10.1016/0968-0004(76)90030-X  0.063
1967 Ling JK, Nicholls DG, Thomas CDB. Immobilization of Southern Elephant Seals with Succinylcholine Chloride The Journal of Wildlife Management. 31: 468. DOI: 10.2307/3798126  0.062
1992 Nicholls DG. Neurotransmission. A retrograde step forward. Nature. 360: 106-7. PMID 1359424 DOI: 10.1038/360106a0  0.061
2004 Nicholls D, Melov S. Special issue: Mitochondria and aging - Facts and fancies Aging Cell. 3: 1. DOI: 10.1111/j.1474-9728.2003.00080.x  0.06
2013 Nicholls DG, Ferguson S. Bioenergetics: Fourth Edition Bioenergetics: Fourth Edition. 1-419.  0.056
2006 Nicholls DG. The physiological regulation of uncoupling proteins. Biochimica Et Biophysica Acta. 1757: 459-66. PMID 16725104 DOI: 10.1016/j.bbabio.2006.02.005  0.056
2007 Chiurugwi T, Pouteau S, Nicholls D, Tooke F, Ordidge M, Battey N. Floral meristem indeterminacy depends on flower position and is facilitated by acarpellate gynoecium development in Impatiens balsamina. The New Phytologist. 173: 79-90. PMID 17176395 DOI: 10.1111/j.1469-8137.2006.01899.x  0.055
2012 Nicholls D, Gerencser A, Goehring I, Brand M, Mulder H. Mitochondria and the control of insulin secretion Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1817: S4-S5. DOI: 10.1016/j.bbabio.2012.06.022  0.055
2012 Alcaraz L, Bailey A, Cadogan E, Connolly S, Jewell R, Jordan S, Kindon N, Lister A, Lawson M, Mullen A, Dainty I, Nicholls D, Paine S, Pairaudeau G, Stocks MJ, et al. From libraries to candidate: the discovery of new ultra long-acting dibasic β₂-adrenoceptor agonists. Bioorganic & Medicinal Chemistry Letters. 22: 689-95. PMID 22079756 DOI: 10.1016/j.bmcl.2011.10.049  0.054
1993 Nicholls DG. The glutamatergic nerve terminal. European Journal of Biochemistry / Febs. 212: 613-31. PMID 8096460 DOI: 10.1111/j.1432-1033.1993.tb17700.x  0.053
1985 Cunningham S, Leslie P, Hopwood D, Illingworth P, Jung RT, Nicholls DG, Peden N, Rafael J, Rial E. The characterization and energetic potential of brown adipose tissue in man. Clinical Science (London, England : 1979). 69: 343-8. PMID 2998687 DOI: 10.1042/cs0690343  0.053
2002 Nicholls D. Mitochondrial bioenergetics, aging, and aging-related disease. Science of Aging Knowledge Environment : Sage Ke. 2002: pe12. PMID 14603000 DOI: 10.1126/sageke.2002.31.pe12  0.053
2012 Mallajosyula JK, Kaur D, Chinta SJ, Rajagopalan S, Rane A, Nicholls DG, Di Monte DA, Macarthur H, Andersen JK. Correction: MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology Plos One. 7. DOI: 10.1371/Annotation/3C37Bef4-Bb5E-4F1E-8551-01Afc006Df90  0.052
2016 Nicholls DG. The curious bioenergetics of the beta-cell Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1857: e16. DOI: 10.1016/j.bbabio.2016.04.389  0.048
1972 Hampton JR, Nicholls DG, Mitchell JR. Evidence for two separate effects of adenosine diphosphate on human platelets. Thrombosis Et Diathesis Haemorrhagica. 28: 419-30. PMID 4649276  0.044
2023 Khatri P, Nepal P, Sahoo K, Bergman R, Nicholls D, Gray A. California's harvested wood products: A time-dependent assessment of life cycle greenhouse gas emissions. The Science of the Total Environment. 163918. PMID 37164097 DOI: 10.1016/j.scitotenv.2023.163918  0.043
2007 Nicholls DG, Robertson CJR. Validating locations from CLS:Argos satellite telemetry Notornis. 54: 121-136.  0.043
1977 Nicholls DG. Hormonal control of brown-adipose-tissue metabolism [proceedings]. Biochemical Society Transactions. 5: 908-12. PMID 199500 DOI: 10.1042/bst0050908  0.043
1992 Nicholls D. A bioenergetic approach to the nerve terminal Biochimica Et Biophysica Acta - Bioenergetics. 1101: 264-265. PMID 1352992 DOI: 10.1016/0005-2728(92)90241-S  0.041
1992 NICHOLLS D. A bioenergetic approach to the nerve terminal Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1101: 264-265. DOI: 10.1016/S0005-2728(05)80036-2  0.041
2016 Nicholls DG, Rial E. A novel regulatory mechanism for the brown-fat uncoupling protein? Nature Structural & Molecular Biology. 23: 364-5. PMID 27142321 DOI: 10.1038/nsmb.3221  0.039
1972 Nicholls DG, Hampton JR. Density gradient separation of human platelets from plasma and the role of plasma in adenosine diphosphate induced platelet electrophoretic mobility changes. Thrombosis Et Diathesis Haemorrhagica. 27: 425-33. PMID 4662609  0.039
1996 Nicholls DG. Review of: The Black Columbiad: Defining Moments in African American Literature and Culture Modernism/Modernity. 3: 160-162. DOI: 10.1353/mod.1996.0026  0.037
2007 Söhle IS, Robertson CJR, Nicholls DG, Mouritsen H, Frost B, Moller H. Satellite tracking of sooty shearwaters (Puffinus griseus) during their pre-laying "exodus" and incubation Notornis. 54: 180-188.  0.036
1971 Nicholls DG, Hampton JR, Mitchell JR. Cyclical changes in plasma-lysolecithin induced by oral contraceptives. Lancet. 2: 1428-9. PMID 4107615  0.035
2007 Nicholls DG. Plumages of northern (Diomedea sanfordi) and southern royal (D. epomophora) albatrosses observed in chilean seas inSeptember 2004 Notornis. 54: 158-167.  0.033
1988 Jung RT, Leslie P, Nicholls DG, Cunningham S, Isles TE. Energy expenditure in normal and diabetic man: the role of brown adipose tissue. Health Bulletin. 46: 55-62. PMID 3280517  0.032
2023 Clark BL, Carneiro APB, Pearmain EJ, Rouyer MM, Clay TA, Cowger W, Phillips RA, Manica A, Hazin C, Eriksen M, González-Solís J, Adams J, Albores-Barajas YV, Alfaro-Shigueto J, Alho MS, ... ... Nicholls DG, et al. Global assessment of marine plastic exposure risk for oceanic birds. Nature Communications. 14: 3665. PMID 37402727 DOI: 10.1038/s41467-023-38900-z  0.032
1970 Nicholls DG. Dispersal and dispersion in relation to the birthsite of the southern elephant seal, mirounga leonina (L.), of macquarie island Mammalia. 34: 598-616. DOI: 10.1515/mamm.1970.34.4.598  0.031
2011 Stocks MJ, Alcaraz L, Bailey A, Bonnert R, Cadogan E, Christie J, Connolly S, Cook A, Fisher A, Flaherty A, Hill S, Humphries A, Ingall A, Jordan S, Lawson M, ... ... Nicholls D, et al. Design driven HtL: The discovery and synthesis of new high efficacy β₂-agonists. Bioorganic & Medicinal Chemistry Letters. 21: 4027-31. PMID 21652207 DOI: 10.1016/j.bmcl.2011.04.135  0.031
1984 Nicholls DG, Locke RM. Thermogenic mechanisms in brown fat. Physiological Reviews. 64: 1-64. PMID 6320232  0.03
1983 Nicholls DG. The thermogenic mechanism of brown adipose tissue. Review. Bioscience Reports. 3: 431-41. PMID 6882887 DOI: 10.1007/BF01121954  0.028
1972 Hampton JR, Nicholls DG. Effect of detergents on platelet electrophoresis and aggregation, and the possible relation of plasma surface activity to thrombosis. Thrombosis Et Diathesis Haemorrhagica. 28: 408-18. PMID 4649275  0.028
2007 Nicholls DG, Robertson CJR, Murray MD. Measuring accuracy and precision for CLS: Argos satellite telemetry locations Notornis. 54: 137-157.  0.027
2015 Fadyl J, McPherson K, Nicholls D. Re/creating entrepreneurs of the self: discourses of worker and employee 'value' and current vocational rehabilitation practices. Sociology of Health & Illness. 37: 506-21. PMID 25565115 DOI: 10.1111/1467-9566.12212  0.026
2004 Nicholls D. Virtual Opera, or Opera between the Ears Journal of the Royal Musical Association. 129: 100-142. DOI: 10.1093/jrma/fkh004  0.025
2013 Dutta D, Wilson K, Welsh WD, Nicholls D, Kim S, Cetin L. A new river system modelling tool for sustainable operational management of water resources Journal of Environmental Management. 121: 13-28. PMID 23518133 DOI: 10.1016/j.jenvman.2013.02.028  0.025
2021 Beal M, Dias MP, Phillips RA, Oppel S, Hazin C, Pearmain EJ, Adams J, Anderson DJ, Antolos M, Arata JA, Arcos JM, Arnould JPY, Awkerman J, Bell E, Bell M, ... ... Nicholls D, et al. Global political responsibility for the conservation of albatrosses and large petrels. Science Advances. 7. PMID 33658194 DOI: 10.1126/sciadv.abd7225  0.024
2000 Nicholls D, Murray M, Butcher E, Moors P. Time Spent in Exclusive Economic Zones of Southern Oceans by Non-breeding Wandering Albatrosses (Diomedea spp.): Implications for National Responsibilities for Conservation Emu - Austral Ornithology. 100: 318-323. DOI: 10.1071/MU9949  0.023
2000 Nicholls DG, Murray MD, Butcher EC, Moors PJ. Time spent in Exclusive Economic Zones of southern oceans by non-breeding Wandering Albatrosses (Diomedea spp.): Implications for national responsibilities for conservation Emu. 100: 318-323.  0.023
2003 Murray MD, Nicholls DG, Butcher E, Moors PJ, Walker K, Elliott G. How Wandering Albatrosses use weather systems to fly long distances. 3. The contributions of Antarctic LOWS to eastward, southward and northward flight Emu. 103: 111-120. DOI: 10.1071/MU01068  0.023
2015 Austin RP, Bennion C, Bonnert RV, Cheema L, Cook AR, Cox RJ, Ebden MR, Gaw A, Grime K, Meghani P, Nicholls D, Phillips C, Smith N, Steele J, Stonehouse JP. Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists. Bioorganic & Medicinal Chemistry Letters. 25: 1616-20. PMID 25708618 DOI: 10.1016/j.bmcl.2015.01.067  0.022
2005 Nicholls D. Does physiotherapy have a certain future? Physiotherapy Theory and Practice. 21: 1-2. PMID 16385938 DOI: 10.1080/09593980590948813  0.021
2003 Komins BJ, Nicholls D. Cultivating Critical Self-Reflection in an International Context: The Development of an American Studies Curriculum in Turkey College Literature. 30: 68-87. DOI: 10.1353/LIT.2003.0043  0.021
2003 Komins BJ, Nicholls DG. Cultivating critical self-reflection in an international context: The development of an American Studies Curriculum in Turkey College Literature. 30: 68-87.  0.021
1984 Nicholls D. Chapter 2 Mechanisms of energy transduction New Comprehensive Biochemistry. 9: 29-48. DOI: 10.1016/S0167-7306(08)60312-9  0.021
2020 Carneiro APB, Pearmain EJ, Oppel S, Clay TA, Phillips RA, Bonnet‐Lebrun A, Wanless RM, Abraham E, Richard Y, Rice J, Handley J, Davies TE, Dilley BJ, Ryan PG, Small C, ... ... Nicholls DG, et al. A framework for mapping the distribution of seabirds by integrating tracking, demography and phenology Journal of Applied Ecology. 57: 514-525. DOI: 10.1111/1365-2664.13568  0.021
2002 Murray MD, Nicholls DG, Butcher E, Moors PJ. How Wandering Albatrosses use weather systems to fly long distances. 1. An analytical method and its application to flights in the Tasman Sea Emu. 102: 377-385. DOI: 10.1071/MU01010  0.019
1997 Nicholls DG, Murray MD, Butcher E, Moors P. Weather systems determine the non-breeding distribution of Wandering Albatrosses over southern oceans Emu. 97: 240-244.  0.019
2003 Murray MD, Nicholls DG, Butcher E, Moors PJ. How Wandering Albatrosses use weather systems to fly long distances. 2. The use of eastward-moving cold fronts from Antarctic LOWS to travel westwards across the Indian Ocean Emu. 103: 59-65. DOI: 10.1071/MU01011  0.018
2023 Khatri P, Nepal P, Sahoo K, Bergman R, Nicholls D, Gray A. Corrigendum to 'California's harvested wood products: A time-dependent assessment of life cycle greenhouse gas emissions' [Sci. Total Environ. 886 (2023) 163918]. The Science of the Total Environment. 909: 168304. PMID 37993353 DOI: 10.1016/j.scitotenv.2023.168304  0.017
1998 Reinke K, Butcher EC, Russell CJ, Nicholls DG, Murray MD. Understanding the flight movements of a non-breeding wandering albatross, Diomedea exulans gibsoni, using a geographic information system Australian Journal of Zoology. 46: 171-181.  0.014
1998 Reinke K, Butcher EC, Russell CJ, Nicholls DG, Murray MD. Understanding the flight movements of a non-breeding wandering albatross, Diomedea exulans gibsoni, using a geographic information system Australian Journal of Zoology. 46: 171. DOI: 10.1071/ZO97046  0.014
2000 Nicholls D, Bernardi P, Brand M, Halestrap A, Lemasters J, Reynolds I. Apoptosis and the laws of thermodynamics [1] (multiple letters) Nature Cell Biology. 2: E172-E173. PMID 11025673 DOI: 10.1038/35036416  0.011
2005 Nicholls DG, Robertson CJR, Naef-Daenzer B. Evaluating distribution modelling using kernel functions for northern royal albatrosses (Diomedea sanfordi) at sea off South America Notornis. 52: 223-235.  0.011
2023 Elvidge J, Hopkin G, Narayanan N, Nicholls D, Dawoud D. Diagnostics and treatments of COVID-19: two-year update to a living systematic review of economic evaluations. Frontiers in Pharmacology. 14: 1291164. PMID 38035028 DOI: 10.3389/fphar.2023.1291164  0.01
2023 Bykerk VP, Nash P, Nicholls D, Tanaka Y, Winthrop K, Popova C, Tilt N, Haaland D. Long-Term Durability of Certolizumab Pegol in Patients with Rheumatoid Arthritis Over 5 Years: An Analysis of Pooled Clinical Trial Data. Rheumatology and Therapy. PMID 36848009 DOI: 10.1007/s40744-023-00541-5  0.01
2022 Elvidge J, Summerfield A, Nicholls D, Dawoud D. Diagnostics and Treatments of COVID-19: A Living Systematic Review of Economic Evaluations. Value in Health : the Journal of the International Society For Pharmacoeconomics and Outcomes Research. PMID 35181207 DOI: 10.1016/j.jval.2022.01.001  0.01
2019 Ahlsen B, Engebretsen E, Nicholls D, Mengshoel AM. The singular patient in patient-centred care: physiotherapists' accounts of treatment of patients with chronic muscle pain. Medical Humanities. PMID 30918108 DOI: 10.1136/medhum-2018-011603  0.01
2007 Nicholls DG. Chair's introduction Novartis Foundation Symposium. 287: 1-3. DOI: 10.1002/9780470725207.ch1  0.01
2007 Nicholls DG, Larsson NG, Spiegelman BM, Jacobs HT, Brand MD, Lemasters JJ, Martinou JC, O'Rourke B, Shirihai O, Turnbull DM, Halestrap AP, Schon EA, Giulivi C. Discussion Novartis Foundation Symposium. 287: 208-213.  0.01
2007 Nicholls DG, Robertson CJR. Assessing flight characteristics for the Chatham albatross (Thalassarche eremita) from satellite tracking Notornis. 54: 168-179.  0.01
2007 Spiegelman BM, Brand MD, Nicholls DG, Giulivi C, Adam-Vizi V, Larsson NG, Beal MF, Lemasters JJ, O'Rourke B, Reynolds IJ, Halestrap AP, Orrenius S, Bernardi P, Schon EA, Bednarczyk P, et al. Discussion Novartis Foundation Symposium. 287: 80-91.  0.01
2006 Yoshida M, Michel H, Sazanov L, Yoshikawa S, Barber J, Lanyi J, Balashov S, Shuvalov V, Yakovlev A, Shkuropatova T, Vasilieva L, Shkuropatov A, Gast P, Dunn S, Del Rizzo P, ... ... Nicholls D, et al. MITCHELL MEDAL LECTURE Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1757: 1-551. DOI: 10.1016/j.bbabio.2006.06.009  0.01
2005 Nicholls DG. The short fiction of George Wylie Henderson African American Review. 39: 491-500.  0.01
2002 Nicholls D, Robertson C, Prince P, Murray M, Walker K, Elliott G. Foraging niches of three Diomedea albatrosses Marine Ecology Progress Series. 231: 269-277. DOI: 10.3354/MEPS231269  0.01
2002 Nicholls DG. Teaching American Literature in Francophone West Africa Pedagogy: Critical Approaches to Teaching Literature, Language, Composition, and Culture. 2: 392-395. DOI: 10.1215/15314200-2-3-392  0.01
2002 Nicholls DG, Robertson CJR, Prince PA, Murray MD, Walker KJ, Elliott GP. Foraging niches of three Diomedea albatrosses Marine Ecology Progress Series. 231: 269-277.  0.01
2001 Freeman AND, Wilson KJ, Nicholls DG. Westland Petrels and the Hoki fishery: Determining co-occurrence using satellite telemetry Emu. 101: 47-56. DOI: 10.1071/MU00061  0.01
1999 Nicholls DG. Migrant Labor, Folklore, and Resistance in Hurston's Polk County: Reframing Mules and Men African American Review. 33: 467. DOI: 10.2307/2901213  0.01
1998 Nicholls D, Stampton P, Klomp N, Schultz M. Post-breeding Flight to Antarctic Waters by a Short-tailed Shearwater Puffinus tenuirostris Emu - Austral Ornithology. 98: 79-82. DOI: 10.1071/MU98007F  0.01
1997 Nicholls DG. The Dialect of Modernism: Race, Language, and Twentieth-Century Literature. Michael North Modern Philology. 95: 276-281. DOI: 10.1086/392488  0.01
1997 Freeman AND, Nicholls DG, Wilson KJ, Bartle JA. Radio- and satellite-tracking westland petrels Procellaria westlandica Marine Ornithology. 25: 31-36.  0.01
1983 Nicholls D. Biological Energy Transduction: the Uroboros Febs Letters. 154: 219-219. DOI: 10.1016/0014-5793(83)80910-7  0.01
1972 Nicholls DG, Garland PB. Chapter III Electrode Measurements of Carbon Dioxide Methods in Microbiology. 6: 55-63. DOI: 10.1016/S0580-9517(08)70594-4  0.01
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