Henry Klassen - Publications

Affiliations: 
Children's Hospital of Orange County, Orange, California, United States 

81 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Chen L, Yang J, Klassen H. Immune Responses to Sequential Binocular Transplantation of Allogeneic Retinal Progenitor Cells to the Vitreous Cavity in Mice. International Journal of Molecular Sciences. 24. PMID 37047179 DOI: 10.3390/ijms24076205  0.427
2021 Yu JJ, Azzam DB, Chwa M, Schneider K, Cho JH, Hsiang C, Klassen H, Kenney MC, Yang J. Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs). Stem Cells International. 2021: 6655372. PMID 33628267 DOI: 10.1155/2021/6655372  0.335
2019 Singh MS, Park SS, Albini TA, Canto-Soler MV, Klassen H, MacLaren RE, Takahashi M, Nagiel A, Schwartz SD, Bharti K. Retinal stem cell transplantation: Balancing safety and potential. Progress in Retinal and Eye Research. 100779. PMID 31494256 DOI: 10.1016/J.Preteyeres.2019.100779  0.484
2017 Yang J, Menges S, Gu P, Tongbai R, Samuel M, Prather RS, Klassen H. Porcine Neural Progenitor Cells Derived from Tissue at Different Gestational Ages Can Be Distinguished by Global Transcriptome. Cell Transplantation. 26: 1582-1595. PMID 29113465 DOI: 10.1177/0963689717723015  0.475
2017 Yang J, Menges S, Gu P, Tongbai R, Samuel M, S Prather R, Klassen H. Porcine neural progenitor cells derived from tissue at different gestational ages can be distinguished by global transcriptome. Cell Transplantation. PMID 28120744 DOI: 10.3727/096368916X694355  0.369
2016 Cooper AE, Cho JH, Menges S, Masood S, Xie J, Yang J, Klassen H. Immunosuppressive Treatment Can Alter Visual Performance in the RCS Rat. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 27008099 DOI: 10.1089/Jop.2015.0134  0.353
2016 Klassen H. Retinal progenitor cells for treatment of retinitis pigmentosa Journal of Clinical & Experimental Ophthalmology. 7. DOI: 10.4172/2155-9570.c1.053  0.35
2015 Klassen H. Stem cells in clinical trials for treatment of retinal degeneration. Expert Opinion On Biological Therapy. 1-8. PMID 26414165 DOI: 10.1517/14712598.2016.1093110  0.473
2015 Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Correction: Transplantation of Adult Mouse iPS Cell-Derived Photoreceptor Precursors Restores Retinal Structure and Function in Degenerative Mice. Plos One. 10: e0125947. PMID 25950705 DOI: 10.1371/journal.pone.0125947  0.352
2014 Sheu J, Klassen H, Bauer G. Cellular manufacturing for clinical applications. Developments in Ophthalmology. 53: 178-88. PMID 24732771 DOI: 10.1159/000357362  0.329
2013 Klassen H. Stem cell clinical trials: toward cell-based therapy for retinal degenerations Clinical Investigation. 3: 703-705. DOI: 10.4155/Cli.13.64  0.458
2012 Yang J, Gu P, Menges S, Klassen H. Quantitative changes in gene transcription during induction of differentiation in porcine neural progenitor cells. Molecular Vision. 18: 1484-504. PMID 22736940  0.313
2012 Klassen H, Tucker BA, Liew CG, La Cour M, Wang HC. Stem cells in large animal models of retinal and neurological disease. Stem Cells International. 2012: 460504. PMID 22666270 DOI: 10.1155/2012/460504  0.498
2012 Yang J, Wang J, Gu P, You XJ, Klassen H. Feline Neural Progenitor Cells I: Long-Term Expansion under Defined Culture Conditions. Stem Cells International. 2012: 108340. PMID 22577394 DOI: 10.1155/2012/108340  0.448
2012 Klassen H, Kiilgaard JF, Warfvinge K, Samuel MS, Prather RS, Wong F, Petters RM, la Cour M, Young MJ. Photoreceptor Differentiation following Transplantation of Allogeneic Retinal Progenitor Cells to the Dystrophic Rhodopsin Pro347Leu Transgenic Pig. Stem Cells International. 2012: 939801. PMID 22567027 DOI: 10.1155/2012/939801  0.567
2012 You XJ, Yang J, Gu P, Liew CG, Klassen HJ. Feline neural progenitor cells II: use of novel plasmid vector and hybrid promoter to drive expression of glial cell line-derived neurotrophic factor transgene. Stem Cells International. 2012: 604982. PMID 22550512 DOI: 10.1155/2012/604982  0.344
2012 Christiansen AT, Tao SL, Smith M, Wnek GE, Prause JU, Young MJ, Klassen H, Kaplan HJ, la Cour M, Kiilgaard JF. Subretinal implantation of electrospun, short nanowire, and smooth poly(ε-caprolactone) scaffolds to the subretinal space of porcine eyes. Stem Cells International. 2012: 454295. PMID 22550509 DOI: 10.1155/2012/454295  0.358
2012 Torrez LB, Perez Y, Yang J, Zur Nieden NI, Klassen H, Liew CG. Derivation of neural progenitors and retinal pigment epithelium from common marmoset and human pluripotent stem cells. Stem Cells International. 2012: 417865. PMID 22550507 DOI: 10.1155/2012/417865  0.547
2012 Christiansen AT, Kiilgaard JF, Smith M, Ejstrup R, Wnek GE, Prause JU, Young MJ, Klassen H, Kaplan H, La Cour M. The influence of brightness on functional assessment by mferg: a study on scaffolds used in retinal cell transplantation in pigs. Stem Cells International. 2012: 263264. PMID 22550501 DOI: 10.1155/2012/263264  0.337
2012 Klassen H. New tool for retinal degeneration research. Investigative Ophthalmology & Visual Science. 53: 926. PMID 22345364 DOI: 10.1167/Iovs.12-9663  0.337
2011 Warfvinge K, Schwartz PH, Kiilgaard JF, la Cour M, Young MJ, Scherfig E, Klassen H. Xenotransplantation of human neural progenitor cells to the subretinal space of nonimmunosuppressed pigs. Journal of Transplantation. 2011: 948740. PMID 21766011 DOI: 10.1155/2011/948740  0.552
2011 Tucker BA, Park IH, Qi SD, Klassen HJ, Jiang C, Yao J, Redenti S, Daley GQ, Young MJ. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. Plos One. 6: e18992. PMID 21559507 DOI: 10.1371/Journal.Pone.0018992  0.466
2011 You XJ, Gu P, Wang J, Song T, Yang J, Liew CG, Klassen H. Efficient transduction of feline neural progenitor cells for delivery of glial cell line-derived neurotrophic factor using a feline immunodeficiency virus-based lentiviral construct. Journal of Ophthalmology. 2011. PMID 20936061 DOI: 10.1155/2011/378965  0.49
2011 Sodha S, Wall K, Redenti S, Klassen H, Young MJ, Tao SL. Microfabrication of a three-dimensional polycaprolactone thin-film scaffold for retinal progenitor cell encapsulation. Journal of Biomaterials Science. Polymer Edition. 22: 443-56. PMID 20566039 DOI: 10.1163/092050610X487738  0.49
2011 Jiang C, Zhang M, Klassen H, Young M. Subretinal transplantation of mouse retinal progenitor cells Neural Regeneration Research. 6: 500-504. DOI: 10.3969/j.issn.1673-5374.2011.07.003  0.451
2010 Wang J, Yang J, Gu P, Klassen H. Effects of glial cell line-derived neurotrophic factor on cultured murine retinal progenitor cells. Molecular Vision. 16: 2850-66. PMID 21203407  0.402
2010 Cho SJ, Lee YS, Lee JI, Bang JI, Yang J, Klassen H, Kong IK. Confirmation of germ-line transmission in the red fluorescence protein (RFP) transgenic cloned male cat. Cellular Reprogramming. 12: 739-47. PMID 20818992 DOI: 10.1089/Cell.2010.0009  0.371
2010 Jiang C, Klassen H, Zhang X, Young M. Laser injury promotes migration and integration of retinal progenitor cells into host retina. Molecular Vision. 16: 983-90. PMID 20577598  0.429
2010 Steedman MR, Tao SL, Klassen H, Desai TA. Enhanced differentiation of retinal progenitor cells using microfabricated topographical cues. Biomedical Microdevices. 12: 363-9. PMID 20077017 DOI: 10.1007/S10544-009-9392-7  0.462
2010 Tucker BA, Redenti SM, Jiang C, Swift JS, Klassen HJ, Smith ME, Wnek GE, Young MJ. The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation. Biomaterials. 31: 9-19. PMID 19775744 DOI: 10.1016/J.Biomaterials.2009.09.015  0.385
2009 Gu P, Yang J, Wang J, Young MJ, Klassen H. Sequential changes in the gene expression profile of murine retinal progenitor cells during the induction of differentiation. Molecular Vision. 15: 2111-22. PMID 19862338  0.355
2009 Kyhn MV, Klassen H, Johansson UE, Warfvinge K, Lavik E, Kiilgaard JF, Prause JU, Scherfig E, Young M, la Cour M. Delayed administration of glial cell line-derived neurotrophic factor (GDNF) protects retinal ganglion cells in a pig model of acute retinal ischemia. Experimental Eye Research. 89: 1012-20. PMID 19735654 DOI: 10.1016/J.Exer.2009.08.014  0.414
2009 Schmitt S, Aftab U, Jiang C, Redenti S, Klassen H, Miljan E, Sinden J, Young M. Molecular characterization of human retinal progenitor cells. Investigative Ophthalmology & Visual Science. 50: 5901-8. PMID 19553622 DOI: 10.1167/Iovs.08-3067  0.466
2009 Aftab U, Jiang C, Tucker B, Kim JY, Klassen H, Miljan E, Sinden J, Young M. Growth kinetics and transplantation of human retinal progenitor cells. Experimental Eye Research. 89: 301-10. PMID 19524569 DOI: 10.1016/J.Exer.2009.03.025  0.573
2009 Kyhn MV, Warfvinge K, Scherfig E, Kiilgaard JF, Prause JU, Klassen H, Young M, la Cour M. Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine model. Electrophysiological and histological characterisation. Experimental Eye Research. 88: 1100-6. PMID 19450446 DOI: 10.1016/J.Exer.2009.01.016  0.414
2009 Redenti S, Neeley WL, Rompani S, Saigal S, Yang J, Klassen H, Langer R, Young MJ. Engineering retinal progenitor cell and scrollable poly(glycerol-sebacate) composites for expansion and subretinal transplantation. Biomaterials. 30: 3405-14. PMID 19361860 DOI: 10.1016/J.Biomaterials.2009.02.046  0.527
2009 Yang J, Klassen H, Pries M, Wang W, Nissen MH. Vitreous humor and albumin augment the proliferation of cultured retinal precursor cells. Journal of Neuroscience Research. 87: 495-502. PMID 18803297 DOI: 10.1002/Jnr.21873  0.474
2008 Redenti S, Tao S, Yang J, Gu P, Klassen H, Saigal S, Desai T, Young MJ. Retinal tissue engineering using mouse retinal progenitor cells and a novel biodegradable, thin-film poly(e-caprolactone) nanowire scaffold. Journal of Ocular Biology, Diseases, and Informatics. 1: 19-29. PMID 20072632 DOI: 10.1007/S12177-008-9005-3  0.539
2008 Klassen H, Warfvinge K, Schwartz PH, Kiilgaard JF, Shamie N, Jiang C, Samuel M, Scherfig E, Prather RS, Young MJ. Isolation of progenitor cells from GFP-transgenic pigs and transplantation to the retina of allorecipients. Cloning and Stem Cells. 10: 391-402. PMID 18729769 DOI: 10.1089/Clo.2008.0010  0.583
2008 Tucker B, Klassen H, Yang L, Chen DF, Young MJ. Elevated MMP Expression in the MRL Mouse Retina Creates a Permissive Environment for Retinal Regeneration. Investigative Ophthalmology & Visual Science. 49: 1686-95. PMID 18385092 DOI: 10.1167/Iovs.07-1058  0.407
2008 Klassen H, Reubinoff B. Stem cells in a new light. Nature Biotechnology. 26: 187-8. PMID 18259172 DOI: 10.1038/Nbt0208-187  0.448
2008 Neeley WL, Redenti S, Klassen H, Tao S, Desai T, Young MJ, Langer R. A microfabricated scaffold for retinal progenitor cell grafting. Biomaterials. 29: 418-26. PMID 17961646 DOI: 10.1016/J.Biomaterials.2007.10.007  0.456
2007 Klassen H. Recruitment of endogenous neural progenitor cells by malignant neoplasms of the central nervous system. Current Stem Cell Research & Therapy. 2: 113-9. PMID 18220896 DOI: 10.2174/157488807780599257  0.399
2007 Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ. Neural progenitor cells lack immunogenicity and resist destruction as allografts. 2003. Ocular Immunology and Inflammation. 15: 261-73. PMID 17613840 DOI: 10.1080/09273940701382242  0.494
2007 Klassen H, Schwartz PH, Ziaeian B, Nethercott H, Young MJ, Bragadottir R, Tullis GE, Warfvinge K, Narfstrom K. Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat. Veterinary Ophthalmology. 10: 245-53. PMID 17565557 DOI: 10.1111/J.1463-5224.2007.00547.X  0.733
2007 Tao S, Young C, Redenti S, Zhang Y, Klassen H, Desai T, Young MJ. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab On a Chip. 7: 695-701. PMID 17538710 DOI: 10.1039/B618583E  0.522
2007 Zhang Y, Klassen HJ, Tucker BA, Perez MT, Young MJ. CNS progenitor cells promote a permissive environment for neurite outgrowth via a matrix metalloproteinase-2-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4499-506. PMID 17460063 DOI: 10.1523/JNEUROSCI.0200-07.2007  0.347
2007 Ng TF, Klassen HJ, Hori J, Young MJ. Retinal transplantation. Chemical Immunology and Allergy. 92: 300-16. PMID 17264505 DOI: 10.1159/000099280  0.421
2007 Klassen H, Kiilgaard JF, Zahir T, Ziaeian B, Kirov I, Scherfig E, Warfvinge K, Young MJ. Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients. Stem Cells (Dayton, Ohio). 25: 1222-30. PMID 17218397 DOI: 10.1634/Stemcells.2006-0541  0.776
2007 Li S, Schwartz PH, Kirov I, Klassen HJ. Characterization of Stem Cells Using Reverse Transcriptase Polymerase Chain Reaction Human Stem Cell Manual. 127-148. DOI: 10.1016/B978-012370465-8/50015-6  0.581
2006 Zahir T, Klassen H, Tomita M, Young MJ. Sorbitol causes preferential selection of Muller glial precursors from late retinal progenitor cells in vitro. Molecular Vision. 12: 1606-14. PMID 17200660  0.426
2006 Warfvinge K, Kiilgaard JF, Klassen H, Zamiri P, Scherfig E, Streilein W, Prause JU, Young MJ. Retinal progenitor cell xenografts to the pig retina: immunological reactions. Cell Transplantation. 15: 603-12. PMID 17176612 DOI: 10.3727/000000006783981594  0.487
2006 Yang J, Klassen H, Pries M, Wang W, Nissen MH. Aqueous humor enhances the proliferation of rat retinal precursor cells in culture, and this effect is partially reproduced by ascorbic acid. Stem Cells (Dayton, Ohio). 24: 2766-75. PMID 16902197 DOI: 10.1634/Stemcells.2006-0103  0.43
2006 Klassen H. Transplantation of cultured progenitor cells to the mammalian retina. Expert Opinion On Biological Therapy. 6: 443-51. PMID 16610975 DOI: 10.1517/14712598.6.5.443  0.573
2005 Tomita M, Lavik E, Klassen H, Zahir T, Langer R, Young MJ. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells. Stem Cells (Dayton, Ohio). 23: 1579-88. PMID 16293582 DOI: 10.1634/Stemcells.2005-0111  0.518
2005 Warfvinge K, Kiilgaard JF, Lavik EB, Scherfig E, Langer R, Klassen HJ, Young MJ. Retinal progenitor cell xenografts to the pig retina: morphologic integration and cytochemical differentiation. Archives of Ophthalmology (Chicago, Ill. : 1960). 123: 1385-93. PMID 16219730 DOI: 10.1001/Archopht.123.10.1385  0.483
2005 Schwartz PH, Nethercott H, Kirov II, Ziaeian B, Young MJ, Klassen H. Expression of neurodevelopmental markers by cultured porcine neural precursor cells. Stem Cells (Dayton, Ohio). 23: 1286-94. PMID 16100001 DOI: 10.1634/Stemcells.2004-0306  0.739
2005 Zahir T, Klassen H, Young MJ. Effects of ciliary neurotrophic factor on differentiation of late retinal progenitor cells. Stem Cells (Dayton, Ohio). 23: 424-32. PMID 15749937 DOI: 10.1634/Stemcells.2004-0199  0.547
2005 Lavik EB, Klassen H, Warfvinge K, Langer R, Young MJ. Fabrication of degradable polymer scaffolds to direct the integration and differentiation of retinal progenitors. Biomaterials. 26: 3187-96. PMID 15603813 DOI: 10.1016/J.Biomaterials.2004.08.022  0.472
2004 Klassen HJ, Ng TF, Kurimoto Y, Kirov I, Shatos M, Coffey P, Young MJ. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Investigative Ophthalmology & Visual Science. 45: 4167-73. PMID 15505071 DOI: 10.1167/Iovs.04-0511  0.697
2004 Klassen H, Ziaeian B, Kirov II, Young MJ, Schwartz PH. Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors. Journal of Neuroscience Research. 77: 334-43. PMID 15248289 DOI: 10.1002/Jnr.20183  0.749
2004 Klassen H, Sakaguchi DS, Young MJ. Stem cells and retinal repair. Progress in Retinal and Eye Research. 23: 149-81. PMID 15094129 DOI: 10.1016/J.Preteyeres.2004.01.002  0.543
2003 Schwartz PH, Bryant PJ, Fuja TJ, Su H, O'Dowd DK, Klassen H. Isolation and characterization of neural progenitor cells from post-mortem human cortex. Journal of Neuroscience Research. 74: 838-51. PMID 14648588 DOI: 10.1002/Jnr.10854  0.477
2003 Klassen HJ, Imfeld KL, Kirov II, Tai L, Gage FH, Young MJ, Berman MA. Expression of cytokines by multipotent neural progenitor cells. Cytokine. 22: 101-6. PMID 12849709 DOI: 10.1016/S1043-4666(03)00120-0  0.615
2003 Hori J, Ng TF, Shatos M, Klassen H, Streilein JW, Young MJ. Neural progenitor cells lack immunogenicity and resist destruction as allografts. Stem Cells (Dayton, Ohio). 21: 405-16. PMID 12832694 DOI: 10.1634/Stemcells.21-4-405  0.504
2003 Mizumoto H, Mizumoto K, Shatos MA, Klassen H, Young MJ. Retinal transplantation of neural progenitor cells derived from the brain of GFP transgenic mice. Vision Research. 43: 1699-708. PMID 12818339 DOI: 10.1016/S0042-6989(03)00235-9  0.562
2003 Klassen H, Imfeld KL, Ray J, Young MJ, Gage FH, Berman MA. The immunological properties of adult hippocampal progenitor cells. Vision Research. 43: 947-56. PMID 12668064 DOI: 10.1016/S0042-6989(03)00094-4  0.436
2001 Mizumoto H, Mizumoto K, Whiteley SJO, Shatos M, Klassen H, Young MJ. Transplantation of Human Neural Progenitor Cells to the Vitreous Cavity of the Royal College of Surgeons Rat. Cell Transplantation. 10: 223-233. PMID 28858580 DOI: 10.3727/000000001783986936  0.448
2001 Whiteley SJ, Klassen H, Coffey PJ, Young MJ. Photoreceptor rescue after low-dose intravitreal IL-1beta injection in the RCS rat. Experimental Eye Research. 73: 557-68. PMID 11825026 DOI: 10.1006/Exer.2001.1066  0.315
2001 Klassen H, Schwartz MR, Bailey AH, Young MJ. Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes. Neuroscience Letters. 312: 180-2. PMID 11602340 DOI: 10.1016/S0304-3940(01)02215-7  0.373
2001 Mizumoto H, Mizumoto K, Whiteley SJ, Shatos M, Klassen H, Young MJ. Transplantation of human neural progenitor cells to the vitreous cavity of the Royal College of Surgeons rat. Cell Transplantation. 10: 223-33. PMID 11332637 DOI: 10.3727/000000001783986936  0.533
2001 Klassen H, Whiteley SJ, Young MJ, Lund RD. Graft location affects functional rescue following RPE cell transplantation in the RCS rat. Experimental Neurology. 169: 114-21. PMID 11312564 DOI: 10.1006/Exnr.2000.7617  0.601
2001 Shatos MA, Mizumoto K, Mizumoto H, Kurimoto Y, Klassen H, Young MJ. Multipotent stem cells from the brain and retina of green mice E-Biomed. 2: 13-15. DOI: 10.1089/152489001750064990  0.54
2000 Young MJ, Ray J, Whiteley SJ, Klassen H, Gage FH. Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Molecular and Cellular Neurosciences. 16: 197-205. PMID 10995547 DOI: 10.1006/Mcne.2000.0869  0.539
1998 Sauvé Y, Klassen H, Whiteley SJ, Lund RD. Visual field loss in RCS rats and the effect of RPE cell transplantation. Experimental Neurology. 152: 243-50. PMID 9710524 DOI: 10.1006/Exnr.1998.6849  0.618
1996 Sauvé Y, Klassen H, Whiteley SJO, Litchfield T, Lund RD. Functional preservation following RPE grafting: I. Retinotopic mapping in the superior colliculus Investigative Ophthalmology and Visual Science. 37: S93.  0.473
1996 Whiteley SJO, Klassen H, Sauvé Y, Litchfield T, Lund RD. Functional preservation following RPE grafting: II. Correlation of SC responses with pupillometry and anatomy Investigative Ophthalmology and Visual Science. 37: S93.  0.471
1990 Klassen H, Lund RD. Retinal graft-mediated pupillary responses in rats: restoration of a reflex function in the mature mammalian brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 578-87. PMID 2303861 DOI: 10.1523/Jneurosci.10-02-00578.1990  0.612
1990 Klassen H, Lund RD. Parameters of retinal graft-mediated responses are related to underlying target innervation. Brain Research. 533: 181-91. PMID 2289140 DOI: 10.1016/0006-8993(90)91338-H  0.599
1988 Klassen H, Lund RD. Anatomical and behavioral correlates of a xenograft-mediated pupillary reflex. Experimental Neurology. 102: 102-8. PMID 2846337 DOI: 10.1016/0014-4886(88)90082-9  0.6
1987 Klassen H, Lund RD. Retinal transplants can drive a pupillary reflex in host rat brains. Proceedings of the National Academy of Sciences of the United States of America. 84: 6958-60. PMID 3477821 DOI: 10.1073/Pnas.84.19.6958  0.6
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